                         SEQUENCE LISTING

<110>  AMGEN INC.
       BATES, Darren L.
       LIU, Zhi
       LEE, TaeWeon
       MICHAELS, Mark Leo
       WANG, Zhulun
 
<120>  ENGINEERED NRG-1 VARIANTS WITH IMPROVED SELECTIVITY TOWARD ErbB4 
       BUT NOT AGAINST ErbB3

<130>  A-2828-WO-PCT

<150>  63/209,248
<151>  2021-06-10

<160>  229   

<170>  PatentIn version 3.5

<210>  1
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  1

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly 
    50                  55                  60                  


Gly Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
65                  70                  75                  80  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        115                 120                 125             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr 
    130                 135                 140                 


Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp 
145                 150                 155                 160 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                165                 170                 175     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Pro Gly Lys 
    290                 295 


<210>  2
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C)::1KmodT482V,M493L)::huFcSEFL2 (Pb)

<400>  2

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser 
    50                  55                  60                  


Val Ala Ser Ser Gly Ser Gly Ser Ala Thr His Leu Asp Lys Thr His 
65                  70                  75                  80  


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                85                  90                  95      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            100                 105                 110         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        115                 120                 125             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    130                 135                 140                 


Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser 
145                 150                 155                 160 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                165                 170                 175     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            180                 185                 190         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        195                 200                 205             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    210                 215                 220                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
225                 230                 235                 240 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                245                 250                 255     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            260                 265                 270         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        275                 280                 285             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 300             


<210>  3
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C)::(G4A)2:G4::huFcSEFL2 (Pb)

<400>  3

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  4
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C)((G4E)2)::G4::huFcSEFL2 (Pb)

<400>  4

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Glu Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  5
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C)::(G4S)2::G4::huFcSEFL2 (Pb)

<400>  5

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  6
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C)(G4E)::G4S::G4::huFcSEFL2 (Pb)

<400>  6

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  7
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C)(NRGmod)::G4::huFcSEFL2 (Pb)

<400>  7

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Ala Ala Ala Glu Glu Leu Tyr Gln Gly Gly Gly 
    50                  55                  60                  


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
65                  70                  75                  80  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr 
    130                 135                 140                 


Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Lys 
    290         


<210>  8
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D)::1KmodT482V,M493L)::huFcSEFL2 (Pb)

<400>  8

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly 
    50                  55                  60                  


Gly Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
65                  70                  75                  80  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        115                 120                 125             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr 
    130                 135                 140                 


Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp 
145                 150                 155                 160 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                165                 170                 175     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Pro Gly Lys 
    290                 295 


<210>  9
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D)::1KmodT482V,M493L)::huFcSEFL2 (Pb)

<400>  9

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Ser Gly Ser Ala Thr Gly Gly Ser Gly Ser 
    50                  55                  60                  


Val Ala Ser Ser Gly Ser Gly Ser Ala Thr His Leu Asp Lys Thr His 
65                  70                  75                  80  


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                85                  90                  95      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            100                 105                 110         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        115                 120                 125             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    130                 135                 140                 


Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser 
145                 150                 155                 160 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                165                 170                 175     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            180                 185                 190         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        195                 200                 205             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    210                 215                 220                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
225                 230                 235                 240 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                245                 250                 255     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            260                 265                 270         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        275                 280                 285             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 300             


<210>  10
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D)::(G4A)2:G4::huFcSEFL2 (Pb)

<400>  10

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  11
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D)::(G4S)2::G4::huFcSEFL2 (Pb)

<400>  11

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Glu Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  12
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D)(G4E)::G4S::G4::huFcSEFL2 (Pb)

<400>  12

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  13
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D)(NRGmod)::G4::huFcSEFL2 (Pb)

<400>  13

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  14
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D)(NRGmod)::G4::huFcSEFL2 (Pb)

<400>  14

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Ala Ala Ala Glu Glu Leu Tyr Gln Gly Gly Gly 
    50                  55                  60                  


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
65                  70                  75                  80  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr 
    130                 135                 140                 


Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Lys 
    290         


<210>  15
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3H8)::3xG4S::huFcSEFL2 (Pb)

<400>  15

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Gly 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
65                  70                  75                  80  


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                85                  90                  95      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            100                 105                 110         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        115                 120                 125             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    130                 135                 140                 


Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser 
145                 150                 155                 160 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                165                 170                 175     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            180                 185                 190         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        195                 200                 205             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    210                 215                 220                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
225                 230                 235                 240 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                245                 250                 255     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            260                 265                 270         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        275                 280                 285             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 300             


<210>  16
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3H8)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  16

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly 
    50                  55                  60                  


Gly Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
65                  70                  75                  80  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        115                 120                 125             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr 
    130                 135                 140                 


Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp 
145                 150                 155                 160 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                165                 170                 175     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Pro Gly Lys 
    290                 295 


<210>  17
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3H8)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  17

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Gly 
    50                  55                  60                  


Gly Gln Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Asp Lys Thr His 
65                  70                  75                  80  


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                85                  90                  95      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            100                 105                 110         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        115                 120                 125             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    130                 135                 140                 


Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser 
145                 150                 155                 160 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                165                 170                 175     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            180                 185                 190         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        195                 200                 205             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    210                 215                 220                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
225                 230                 235                 240 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                245                 250                 255     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            260                 265                 270         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        275                 280                 285             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 300             


<210>  18
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-S228)(3H8)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  18

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly Gly 
    50                  55                  60                  


Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  19
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1C)::GG::huFcSEFL2 (Pb)

<400>  19

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  20
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-S228)(NRGE1C)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  20

Gly Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr 
65                  70                  75                  80  


Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  21
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-S228)(NRGE1C)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  21

Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
1               5                   10                  15      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            20                  25                  30          


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        35                  40                  45              


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    50                  55                  60                  


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
65                  70                  75                  80  


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                85                  90                  95      


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            100                 105                 110         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        115                 120                 125             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Lys 
145                 150 


<210>  22
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1D)::GG::huFcSEFL2 (Pb)

<400>  22

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  23
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1D)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  23

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Gly 
    50                  55                  60                  


Gly Gln Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Asp Lys Thr His 
65                  70                  75                  80  


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                85                  90                  95      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            100                 105                 110         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        115                 120                 125             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    130                 135                 140                 


Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser 
145                 150                 155                 160 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                165                 170                 175     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            180                 185                 190         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        195                 200                 205             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    210                 215                 220                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
225                 230                 235                 240 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                245                 250                 255     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            260                 265                 270         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        275                 280                 285             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    290                 295                 300             


<210>  24
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-S228)(NRGE1D)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  24

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly Gly 
    50                  55                  60                  


Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  25
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(wt)::GG::huFcSEFL2 (Pb)

<400>  25

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  26
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(wt)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  26

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Gly Gly Gly Gly Gln Gly Gly Gly Gly Gln Gly 
    50                  55                  60                  


Gly Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
65                  70                  75                  80  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                85                  90                  95      


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            100                 105                 110         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        115                 120                 125             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr 
    130                 135                 140                 


Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp 
145                 150                 155                 160 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                165                 170                 175     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            180                 185                 190         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        195                 200                 205             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    210                 215                 220                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
225                 230                 235                 240 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                245                 250                 255     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            260                 265                 270         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        275                 280                 285             


Leu Ser Leu Ser Pro Gly Lys 
    290                 295 


<210>  27
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(wt)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  27

Gly Gly Gly Gln Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr 
65                  70                  75                  80  


Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  28
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-S228)(wt)::3x(G4Q)::huFcSEFL2 (Pb)

<400>  28

Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
1               5                   10                  15      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            20                  25                  30          


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        35                  40                  45              


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    50                  55                  60                  


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
65                  70                  75                  80  


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                85                  90                  95      


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            100                 105                 110         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        115                 120                 125             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Lys 
145                 150 


<210>  29
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1A)::GG::huFcSEFL2 (Pb)

<400>  29

Ser His Leu Val Lys Cys Ala Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  30
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1B)::GG::huFcSEFL2 (Pb)

<400>  30

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  31
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1E)::GG::huFcSEFL2 (Pb)

<400>  31

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  32
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1F)::GG::huFcSEFL2 (Pb)

<400>  32

Ser His Leu Val Lys Cys Ala Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  33
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1G)::GG::huFcSEFL2 (Pb)

<400>  33

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  34
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1H)::GG::huFcSEFL2 (Pb)

<400>  34

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  35
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1J)::GG::huFcSEFL2 (Pb)

<400>  35

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  36
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1J)::GG::huFcSEFL2 (Pb)

<400>  36

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  37
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1K)::GG::huFcSEFL2 (Pb)

<400>  37

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  38
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1L)::GG::huFcSEFL2 (Pb)

<400>  38

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  39
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1M)::GG::huFcSEFL2 (Pb)

<400>  39

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  40
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1N)::GG::huFcSEFL2 (Pb)

<400>  40

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  41
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(NRGE1O)::GG::huFcSEFL2 (Pb)

<400>  41

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  42
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1D3)::GG::huFcSEFL2 (Pb)

<400>  42

Ser His Leu Val Lys Cys Ala Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  43
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1D3)::GG::huFcSEFL2 (Pb)

<400>  43

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Asp Pro Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  44
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47A_D48P_F49H_M50I) huIgG1z SELF2 Fc

<400>  44

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ala Pro 
        35                  40                  45              


His Ile Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  45
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47A_D48P_F49H_M50I) huIgG1z SELF2 Fc

<400>  45

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ala Pro 
        35                  40                  45              


His Ile Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  46
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47K_D48T_F49S_M50L) huIgG1z SELF2 Fc

<400>  46

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Thr 
        35                  40                  45              


Ser Leu Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  47
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47Q_D48S_M50P) huIgG1z SELF2 Fc

<400>  47

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Gln Ser 
        35                  40                  45              


Phe Pro Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  48
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47S_D48A_F49L_M50T) huIgG1z SELF2 Fc

<400>  48

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Ala 
        35                  40                  45              


Leu Thr Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  49
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47S_D48T_F49R_M50V) huIgG1z SELF2 Fc

<400>  49

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Thr 
        35                  40                  45              


Arg Val Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  50
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) huIgG1z SELF2 Fc

<400>  50

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  51
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) (E47K_D48L_F49D_M50I) huIgG1z SELF2 Fc

<400>  51

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Leu 
        35                  40                  45              


Asp Ile Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  52
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) (E47S_D48S_F49E_M50L) huIgG1z SELF2 Fc

<400>  52

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Ser 
        35                  40                  45              


Glu Leu Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  53
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) (E47T_D48S_F49L_M50L) huIgG1z SELF2 Fc

<400>  53

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Thr Ser 
        35                  40                  45              


Leu Leu Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  54
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229) huIgG1z SELF2 Fc

<400>  54

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  55
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229) huIgG1z SELF2 Fc

<400>  55

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  56
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) 6xHis

<400>  56

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  57
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (D48T_F49Q_M50I) 6xHis

<400>  57

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Thr 
        35                  40                  45              


Gln Ile Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  58
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47A_D48P_F49H_M50I) 6xHis

<400>  58

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ala Pro 
        35                  40                  45              


His Ile Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  59
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47K_D48T_F49S_M50L) 6xHis

<400>  59

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Thr 
        35                  40                  45              


Ser Leu Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  60
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47Q_D48S_M50P) 6xHis

<400>  60

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Gln Ser 
        35                  40                  45              


Phe Pro Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  61
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47S_D48A_F49L_M50T) 6xHis

<400>  61

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Ala 
        35                  40                  45              


Leu Thr Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  62
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1C) (E47S_D48T_F49R_M50V) 6xHis

<400>  62

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Thr 
        35                  40                  45              


Arg Val Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  63
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) 6xHis

<400>  63

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  64
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) (E47K_D48L_F49D_M50I) 6xHis

<400>  64

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Leu 
        35                  40                  45              


Asp Ile Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  65
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) (E47S_D48S_F49E_M50L) 6xHis

<400>  65

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Ser 
        35                  40                  45              


Glu Leu Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  66
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) (E47T_D48S_F49L_M50L) 6xHis

<400>  66

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Thr Ser 
        35                  40                  45              


Leu Leu Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  67
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229)(NRGE1D) (E47V_D48T_F49R_M50L) 6xHis

<400>  67

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Val Thr 
        35                  40                  45              


Arg Leu Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  68
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-F229) 6xHis

<400>  68

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly His His His His His His 
65                  70              


<210>  69
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK):G4SG4:huNRG1(S177-F229)(NRGE1C)

<400>  69

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Phe 
                245                 250                 255     


Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
        355                 360                 365             


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
        515                 520                 525             


Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Phe 
    530                 535                 540                 


Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
545                 550                 555                 560 


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
                565                 570                 575     


<210>  70
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK):G4SG4:huNRG1(S177-F229)(NRGE1D)

<400>  70

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Tyr 
                245                 250                 255     


Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
        355                 360                 365             


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
        515                 520                 525             


Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Tyr 
    530                 535                 540                 


Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
545                 550                 555                 560 


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
                565                 570                 575     


<210>  71
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK):G4SG4:huNRG1(S177-Q237)(NRGE1C)

<400>  71

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Phe 
                245                 250                 255     


Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Tyr Lys Ala Glu Glu Leu Tyr Gln Asp Lys Thr His Thr Cys Pro Pro 
    290                 295                 300                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
305                 310                 315                 320 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            340                 345                 350         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys 
        355                 360                 365             


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val 
    370                 375                 380                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
385                 390                 395                 400 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                405                 410                 415     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            420                 425                 430         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    450                 455                 460                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
465                 470                 475                 480 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                485                 490                 495     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe 
    530                 535                 540                 


Cys Val Asn Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro 
545                 550                 555                 560 


Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys 
                565                 570                 575     


Gln Glu Asp Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
            580                 585                 590         


<210>  72
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK):G4SG4:huNRG1(S177-Q237)(NRGE1D)

<400>  72

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Tyr 
                245                 250                 255     


Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Tyr Lys Ala Glu Glu Leu Tyr Gln Asp Lys Thr His Thr Cys Pro Pro 
    290                 295                 300                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
305                 310                 315                 320 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            340                 345                 350         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys 
        355                 360                 365             


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val 
    370                 375                 380                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
385                 390                 395                 400 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                405                 410                 415     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            420                 425                 430         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    450                 455                 460                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
465                 470                 475                 480 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                485                 490                 495     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe 
    530                 535                 540                 


Cys Val Asn Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro 
545                 550                 555                 560 


Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys 
                565                 570                 575     


Gln Glu Asp Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
            580                 585                 590         


<210>  73
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK)v131(+):G4SG4:huNRG1(S177-F229)(NRGE1C)

<400>  73

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Phe 
                245                 250                 255     


Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
        355                 360                 365             


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Glu Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Glu Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210>  74
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK)v131(+):G4SG4:huNRG1(S177-F229)(NRGE1D)

<400>  74

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Tyr 
                245                 250                 255     


Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
        355                 360                 365             


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Glu Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Glu Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210>  75
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK)v131(+):G4SG4:huNRG1(S177-Q237)(NRGE1C)

<400>  75

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Phe 
                245                 250                 255     


Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Tyr Lys Ala Glu Glu Leu Tyr Gln Asp Lys Thr His Thr Cys Pro Pro 
    290                 295                 300                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
305                 310                 315                 320 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            340                 345                 350         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys 
        355                 360                 365             


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val 
    370                 375                 380                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
385                 390                 395                 400 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                405                 410                 415     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            420                 425                 430         


Glu Met Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    450                 455                 460                 


Asn Asn Tyr Glu Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
465                 470                 475                 480 


Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                485                 490                 495     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520             


<210>  76
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huFcSEFL2(desK)v131(+):G4SG4:huNRG1(S177-Q237)(NRGE1D)

<400>  76

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr 
65                  70                  75                  80  


Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Leu Val Lys 
225                 230                 235                 240 


Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn Gly Gly Glu Cys Tyr 
                245                 250                 255     


Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            260                 265                 270         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp Phe Met Ala Ser Phe 
        275                 280                 285             


Tyr Lys Ala Glu Glu Leu Tyr Gln Asp Lys Thr His Thr Cys Pro Pro 
    290                 295                 300                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
305                 310                 315                 320 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            340                 345                 350         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys 
        355                 360                 365             


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val 
    370                 375                 380                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
385                 390                 395                 400 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                405                 410                 415     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            420                 425                 430         


Glu Met Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    450                 455                 460                 


Asn Asn Tyr Glu Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
465                 470                 475                 480 


Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                485                 490                 495     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520             


<210>  77
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huNRG1(S177-F229)(NRGE1C) ::2X(G4A)G4::huFcSEFL2v131(+)

<400>  77

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    290                 295                 300                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
        355                 360                 365             


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            420                 425                 430         


Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Glu Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     


<210>  78
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huNRG1(S177-F229)(NRGE1C) ::2X(G4E)G4::huFcSEFL2v131(+)

<400>  78

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Glu Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    290                 295                 300                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
        355                 360                 365             


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            420                 425                 430         


Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Glu Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     


<210>  79
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huNRG1(S177-F229)(NRGE1D) ::2X(G4A)G4::huFcSEFL2v131(+)

<400>  79

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    290                 295                 300                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
        355                 360                 365             


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            420                 425                 430         


Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Glu Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     


<210>  80
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  :huNRG1(S177-F229)(NRGE1D) ::2X(G4E)G4::huFcSEFL2v131(+)

<400>  80

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Glu Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Lys Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    290                 295                 300                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
        355                 360                 365             


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            420                 425                 430         


Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Glu Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     


<210>  81
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-S228)(wt)((G4E)2:G4)::huFcSEFL2 (Pb)

<400>  81

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Gly Gly Gly Gly Glu Gly Gly Gly Gly Glu Gly 
    50                  55                  60                  


Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                85                  90                  95      


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            100                 105                 110         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        115                 120                 125             


Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly 
    130                 135                 140                 


Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
145                 150                 155                 160 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                165                 170                 175     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            180                 185                 190         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        195                 200                 205             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    210                 215                 220                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
225                 230                 235                 240 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                245                 250                 255     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            260                 265                 270         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        275                 280                 285             


Ser Leu Ser Pro Gly Lys 
    290                 


<210>  82
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1A1)::GG::huFcSEFL2 (Pb)

<400>  82

Ser His Leu Val Lys Cys Gly Glu Ser Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Ile Glu Asp Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Val 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  83
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1A12)::GG::huFcSEFL2 (Pb)

<400>  83

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu Arg Pro Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  84
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1B4)::GG::huFcSEFL2 (Pb)

<400>  84

Ser His Leu Val Lys Cys Ala Glu Arg Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Ile Glu His Leu Ser Asn Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  85
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1B4)::GG::huFcSEFL2 (Pb)

<400>  85

Ser His Leu Val Lys Cys Gly Glu Arg Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Asp Ser Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  86
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1B9)::GG::huFcSEFL2 (Pb)

<400>  86

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  87
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1C11)::GG::huFcSEFL2 (Pb)

<400>  87

Ser His Leu Val Lys Cys Gly Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Arg Pro Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  88
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1D10)::GG::huFcSEFL2 (Pb)

<400>  88

Ser His Leu Val Lys Cys Ala Glu Arg Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Ile Glu Asp Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  89
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(1D4)::GG::huFcSEFL2 (Pb)

<400>  89

Ser His Leu Val Lys Cys Gly Glu Arg Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu His Ser Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Phe 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  90
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(2E3)::GG::huFcSEFL2 (Pb)

<400>  90

Ser His Leu Val Lys Cys Gly Glu Lys Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Ile Glu Gly Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  91
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(2E4)::GG::huFcSEFL2 (Pb)

<400>  91

Ser His Leu Val Lys Cys Gly Glu Ser Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Arg Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  92
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(2F2)::GG::huFcSEFL2 (Pb)

<400>  92

Ser His Leu Val Lys Cys Ala Glu Ser Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Ile Glu His Pro Ser Asn Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  93
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(2G3)::GG::huFcSEFL2 (Pb)

<400>  93

Ser His Leu Val Lys Cys Gly Glu Arg Gln Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Asp Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  94
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(2G4)::GG::huFcSEFL2 (Pb)

<400>  94

Ser His Leu Val Lys Cys Ala Glu Asn Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Val Glu Gly Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  95
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(2H7)::GG::huFcSEFL2 (Pb)

<400>  95

Ser His Leu Val Lys Cys Gly Glu Lys Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu Asp Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  96
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3A7)::GG::huFcSEFL2 (Pb)

<400>  96

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  97
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3B8)::GG::huFcSEFL2 (Pb)

<400>  97

Ser His Leu Val Lys Cys Gly Glu Arg Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Arg Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  98
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3D6)::GG::huFcSEFL2 (Pb)

<400>  98

Ser His Leu Val Lys Cys Gly Glu Ser Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  99
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3E6)::GG::huFcSEFL2 (Pb)

<400>  99

Ser His Leu Val Lys Cys Gly Glu Lys Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  100
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3E6)::GG::huFcSEFL2 (Pb)

<400>  100

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  101
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3F2)::GG::huFcSEFL2 (Pb)

<400>  101

Ser His Leu Val Lys Cys Ala Glu Asn His Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  102
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3F2)::GG::huFcSEFL2 (Pb)

<400>  102

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  103
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3G3)::GG::huFcSEFL2 (Pb)

<400>  103

Ser His Leu Val Lys Cys Gly Glu Arg Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu His Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  104
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3G9)::GG::huFcSEFL2 (Pb)

<400>  104

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Asn Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  105
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3H5)::GG::huFcSEFL2 (Pb)

<400>  105

Ser His Leu Val Lys Cys Gly Glu Arg His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu Arg Pro Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  106
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(3H8)::GG::huFcSEFL2 (Pb)

<400>  106

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  107
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(_200E)::GG::huFcSEFL2 (Pb)

<400>  107

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  108
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(_200E_KDF)::GG::huFcSEFL2 (Pb)

<400>  108

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  109
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(_FVIEDPSI)::GG::huFcSEFL2 (Pb)

<400>  109

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Asp Pro Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  110
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(v80)::GG::huFcSEFL2 (Pb)

<400>  110

Ser His Leu Val Lys Cys Ala Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  111
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  huNRG1(S177-Q237)(v80.3)::GG::huFcSEFL2 (Pb)

<400>  111

Ser His Leu Val Lys Cys Ala Glu Arg His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Glu Lys Asp 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
    130                 135                 140                 


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  112
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  112

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S Linker

<400>  113

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  114
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1A)

<400>  114

Ser His Leu Val Lys Cys Ala Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  115
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1B)

<400>  115

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  116
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-S228) (NRGE1C)

<400>  116

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser 
    50          


<210>  117
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1C)

<400>  117

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe 
    50              


<210>  118
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1C TQI)

<400>  118

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Thr 
        35                  40                  45              


Gln Ile Ala Ser Phe 
    50              


<210>  119
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1C APHI)

<400>  119

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ala Pro 
        35                  40                  45              


His Ile Ala Ser Phe 
    50              


<210>  120
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1C KTSL)

<400>  120

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Thr 
        35                  40                  45              


Ser Leu Ala Ser Phe 
    50              


<210>  121
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1C QSP)

<400>  121

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Gln Ser 
        35                  40                  45              


Phe Pro Ala Ser Phe 
    50              


<210>  122
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1C SALT)

<400>  122

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Ala 
        35                  40                  45              


Leu Thr Ala Ser Phe 
    50              


<210>  123
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1C STRV)

<400>  123

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Thr 
        35                  40                  45              


Arg Val Ala Ser Phe 
    50              


<210>  124
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1C)

<400>  124

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  125
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-S228) (NRGE1D)

<400>  125

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser 
    50          


<210>  126
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1D)

<400>  126

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe 
    50              


<210>  127
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1D KLDI)

<400>  127

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Leu 
        35                  40                  45              


Asp Ile Ala Ser Phe 
    50              


<210>  128
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1D SSEL)

<400>  128

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Ser Ser 
        35                  40                  45              


Glu Leu Ala Ser Phe 
    50              


<210>  129
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1D TSLL)

<400>  129

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Thr Ser 
        35                  40                  45              


Leu Leu Ala Ser Phe 
    50              


<210>  130
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (NRGE1D VTRL)

<400>  130

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Val Thr 
        35                  40                  45              


Arg Leu Ala Ser Phe 
    50              


<210>  131
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1D)

<400>  131

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  132
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1E)

<400>  132

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  133
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1F)

<400>  133

Ser His Leu Val Lys Cys Ala Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  134
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1G)

<400>  134

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  135
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1H)

<400>  135

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  136
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1I)

<400>  136

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  137
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1J)

<400>  137

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  138
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1K)

<400>  138

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  139
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1L)

<400>  139

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  140
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1M)

<400>  140

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  141
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1N)

<400>  141

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  142
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1O)

<400>  142

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  143
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (NRGE1P)

<400>  143

Ser His Leu Val Lys Cys Ala Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  144
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (1A1)

<400>  144

Ser His Leu Val Lys Cys Gly Glu Ser Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Ile Glu Asp Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Val 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  145
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (1A12)

<400>  145

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu Arg Pro Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  146
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237)  (1A7)

<400>  146

Ser His Leu Val Lys Cys Ala Glu Arg Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Ile Glu His Leu Ser Asn Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  147
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (1B4)

<400>  147

Ser His Leu Val Lys Cys Gly Glu Arg Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Asp Ser Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  148
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (1B9)

<400>  148

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  149
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (1C11)

<400>  149

Ser His Leu Val Lys Cys Gly Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Arg Pro Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  150
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237)   (1D10)

<400>  150

Ser His Leu Val Lys Cys Ala Glu Arg Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Ile Glu Asp Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  151
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (1D3)

<400>  151

Ser His Leu Val Lys Cys Gly Glu Asn Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Asp Pro Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Asp 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  152
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (1D4)

<400>  152

Ser His Leu Val Lys Cys Gly Glu Arg Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu His Ser Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Phe 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  153
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237)(2E3)

<400>  153

Ser His Leu Val Lys Cys Gly Glu Lys Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Ile Glu Gly Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  154
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (2E4)

<400>  154

Ser His Leu Val Lys Cys Gly Glu Ser Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Arg Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  155
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (2F2)

<400>  155

Ser His Leu Val Lys Cys Ala Glu Ser Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Ile Glu His Pro Ser Asn Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  156
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (2G3)

<400>  156

Ser His Leu Val Lys Cys Gly Glu Arg Gln Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Asp Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  157
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (2G4)

<400>  157

Ser His Leu Val Lys Cys Ala Glu Asn Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Val Glu Gly Leu Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  158
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (2H7)

<400>  158

Ser His Leu Val Lys Cys Gly Glu Lys Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu Asp Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  159
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3A7)

<400>  159

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Val 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  160
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3B8)

<400>  160

Ser His Leu Val Lys Cys Gly Glu Arg Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Arg Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  161
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3D6)

<400>  161

Ser His Leu Val Lys Cys Gly Glu Ser Asp Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  162
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3D8)

<400>  162

Ser His Leu Val Lys Cys Gly Glu Lys Asp Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Phe 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  163
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237)(3E6)

<400>  163

Ser His Leu Val Lys Cys Ala Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  164
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237)(3E9)

<400>  164

Ser His Leu Val Lys Cys Ala Glu Asn His Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Val 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  165
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3F2)

<400>  165

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu Gly Pro Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asp Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  166
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3G3)

<400>  166

Ser His Leu Val Lys Cys Gly Glu Arg Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Ile Glu His Leu Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  167
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3G9)

<400>  167

Ser His Leu Val Lys Cys Gly Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Asn Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  168
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3H5)

<400>  168

Ser His Leu Val Lys Cys Gly Glu Arg His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Val Val Glu Arg Pro Ser Ile Pro Ser Arg Phe 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Leu Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  169
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-S228) (3H8)

<400>  169

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser 
    50          


<210>  170
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-F229) (3H8)

<400>  170

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe 
    50              


<210>  171
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (3H8)

<400>  171

Ser His Leu Val Lys Cys Gly Glu Lys His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Tyr Met Val Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Glu Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  172
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (200E)

<400>  172

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  173
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (200E_KDF)

<400>  173

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Glu Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Phe Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  174
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (FVIEDPSI)

<400>  174

Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Asp Pro Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  175
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (v80)

<400>  175

Ser His Leu Val Lys Cys Ala Glu Ser His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Lys Asp 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  176
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRG1(S177-Q237) (v80.3)

<400>  176

Ser His Leu Val Lys Cys Ala Glu Arg His Lys Ser Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Val Ile Glu Gly Ser Ser Ile Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Glu Lys Asp 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
    50                  55                  60      


<210>  177
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<400>  177

Ser His Leu Val Lys Cys Xaa Glu Xaa Xaa Lys Xaa Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Pro Ser Arg Xaa 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Ala Ser Xaa 
    50              


<210>  178
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  178

Phe Met Ile Glu Asp Ser 
1               5       


<210>  179
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  179

Phe Met Ile Glu Gly Pro 
1               5       


<210>  180
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  180

Phe Met Ile Glu His Leu 
1               5       


<210>  181
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  181

Phe Met Val Glu Asp Leu 
1               5       


<210>  182
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  182

Phe Met Val Glu Arg Ser 
1               5       


<210>  183
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  183

Phe Met Val Lys Arg Pro 
1               5       


<210>  184
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  184

Phe Val Ile Glu Asp Pro 
1               5       


<210>  185
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  185

Phe Val Ile Glu Gly Ser 
1               5       


<210>  186
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  186

Phe Val Val Glu Gly Leu 
1               5       


<210>  187
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  187

Tyr Met Ile Glu Asp Leu 
1               5       


<210>  188
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  188

Tyr Met Ile Glu Gly Leu 
1               5       


<210>  189
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  189

Tyr Met Ile Glu His Pro 
1               5       


<210>  190
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  190

Tyr Met Val Glu Asp Leu 
1               5       


<210>  191
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  191

Tyr Met Val Glu Gly Ser 
1               5       


<210>  192
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  192

Tyr Met Val Glu Arg Pro 
1               5       


<210>  193
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  193

Tyr Val Ile Glu Asp Ser 
1               5       


<210>  194
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  194

Tyr Val Ile Glu Gly Ser 
1               5       


<210>  195
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  195

Tyr Val Ile Glu His Leu 
1               5       


<210>  196
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  196

Tyr Val Val Glu Asp Leu 
1               5       


<210>  197
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  197

Tyr Val Val Glu His Ser 
1               5       


<210>  198
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 197-202

<400>  198

Tyr Val Val Glu Arg Pro 
1               5       


<210>  199
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  199

Glu Lys Asp Val Met 
1               5   


<210>  200
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  200

Gln Ala Pro His Ile 
1               5   


<210>  201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  201

Gln Asp Asp Phe Met 
1               5   


<210>  202
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  202

Gln Asp Phe Phe Leu 
1               5   


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  203

Gln Asp Phe Phe Met 
1               5   


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  204

Gln Asp Val Phe Leu 
1               5   


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  205

Gln Asp Val Phe Met 
1               5   


<210>  206
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  206

Gln Glu Asp Phe Met 
1               5   


<210>  207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  207

Gln Glu Thr Gln Ile 
1               5   


<210>  208
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  208

Gln Lys Asp Phe Leu 
1               5   


<210>  209
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  209

Gln Lys Asp Phe Met 
1               5   


<210>  210
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  210

Gln Lys Asp Val Met 
1               5   


<210>  211
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  211

Gln Lys Phe Phe Leu 
1               5   


<210>  212
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  212

Gln Lys Phe Phe Met 
1               5   


<210>  213
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  213

Gln Lys Leu Asp Ile 
1               5   


<210>  214
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  214

Gln Lys Thr Ser Leu 
1               5   


<210>  215
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  215

Gln Lys Val Phe Leu 
1               5   


<210>  216
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  216

Gln Lys Val Phe Met 
1               5   


<210>  217
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  217

Gln Lys Val Val Met 
1               5   


<210>  218
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  218

Gln Asn Asp Phe Leu 
1               5   


<210>  219
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  219

Gln Asn Asp Phe Met 
1               5   


<210>  220
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  220

Gln Asn Val Phe Leu 
1               5   


<210>  221
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  221

Gln Asn Val Phe Met 
1               5   


<210>  222
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  222

Gln Asn Tyr Val Met 
1               5   


<210>  223
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  223

Gln Gln Ser Phe Pro 
1               5   


<210>  224
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  224

Gln Ser Ala Leu Thr 
1               5   


<210>  225
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  225

Gln Ser Ser Glu Leu 
1               5   


<210>  226
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  226

Gln Ser Thr Arg Val 
1               5   


<210>  227
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  227

Gln Thr Ser Leu Leu 
1               5   


<210>  228
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neuregulin variant motif 222-226

<400>  228

Gln Val Thr Arg Leu 
1               5   


<210>  229
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  229

Phe Tyr Lys Ala Glu Glu Leu Tyr Gln 
1               5                   


