                         SEQUENCE LISTING

<110>  NF2 Therapeutics, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING NEUROFIBROMATIC DISORDERS

<130>  148494.000102

<140>  PCT/US22/32679
<141>  2022-06-08

<150>  US 63/202,359
<151>  2021-06-14

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  1

Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 
1               5                   10                  15      


Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 
            20                  25                  30          


Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 
        35                  40                  45              


Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 
    50                  55                  60                  


Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 
65                  70                  75                  80  


Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 
                85                  90                  95      


Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 
            100                 105                 110         


Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 
        115                 120                 125             


Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 
145                 150                 155                 160 


Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 
                165                 170                 175     


Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 
            180                 185                 190         


Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 
        195                 200                 205             


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 
    210                 215                 220                 


Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 
225                 230                 235                 240 


Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 
                245                 250                 255     


Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 
            260                 265                 270         


Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 
        275                 280                 285             


Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 
    290                 295                 300                 


Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 
305                 310                 315                 320 


Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 
                325                 330                 335     


Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 
            340                 345                 350         


Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 
        355                 360                 365             


Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 
    370                 375                 380                 


Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 
385                 390                 395                 400 


Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 
                405                 410                 415     


Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 
            420                 425                 430         


Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 
        435                 440                 445             


Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 
    450                 455                 460                 


Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 
465                 470                 475                 480 


Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 
                485                 490                 495     


Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 
            500                 505                 510         


Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 
        515                 520                 525             


Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 
    530                 535                 540                 


Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 
545                 550                 555                 560 


Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 
                565                 570                 575     


Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe 
            580                 585                 590         


Glu Glu Leu 
        595 


<210>  2
<211>  1799
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  2
atggccggcg cgattgcttc ccggatgtca ttctcctcac ttaaaagaaa acagcctaag       60

acttttaccg tgcggatcgt gactatggat gcagagatgg aattcaactg cgagatgaag      120

tggaagggaa aggacctctt cgacctcgtc tgtcgcacct tgggactgcg ggaaacctgg      180

ttcttcggac tgcagtacac aatcaaggac accgtggcct ggctgaaaat ggacaagaag      240

gtcctggacc acgacgtgtc caaggaagaa cccgtgactt tccactttct ggccaagttc      300

tacccggaga acgctgagga agaactcgtg caggagatca ctcagcatct gttcttttta      360

caagtcaaga agcaaatcct agatgagaag atctactgcc cgccggaagc gtccgtgctt      420

ctggcttcct acgcggtgca ggccaaatat ggagactacg atccctccgt gcacaagcgc      480

gggttcctgg cccaagagga actgctgcct aagcgcgtga tcaacctgta ccagatgacc      540

cccgagatgt gggaggaacg aattacggct tggtacgcgg agcatcgcgg cagagcacgc      600

gatgaagccg agatggagta cctgaagatc gcgcaggatc ttgagatgta cggggtcaac      660

tatttcgcca tccgcaacaa gaagggcacc gaactcctgc ttggagtgga cgcactcggg      720

ctccacatct acgacccgga aaaccgcctg actcccaaga tcagcttccc ttggaacgaa      780

atcagaaaca tttcctactc ggataaggaa ttcacgatca agccactgga caaaaagatt      840

gacgtgttca agttcaactc gtcgaagctg cgcgtgaaca agctgatact gcaactgtgc      900

attggcaatc acgacctgtt tatgcgccgg cggaaggccg actcattgga ggtccaacag      960

atgaaggccc aggcccgcga ggaaaaggct cgcaagcaga tggaacggca gaggctggcc     1020

agagagaagc agatgcggga agaggccgaa cgcacccggg atgaactgga gcgcaggctg     1080

ctgcagatga aggaagaagc aaccatggcc aacgaagcgc tgatgcggag cgaagaaacc     1140

gcggacctgt tggccgaaaa ggctcagatc accgaggaag aagccaagct ccttgcgcaa     1200

aaggccgccg aggccgaaca ggagatgcag agaatcaagg ccaccgccat cagaaccgaa     1260

gaagagaagc ggctcatgga acagaaagtg ttggaagccg aggtgctggc gcttaagatg     1320

gcagaggagt ccgagagaag ggccaaagag gcagaccagc tgaagcagga tctgcaggaa     1380

gcccgggaag ccgagcggcg ggcgaagcag aagctcttgg aaatcgccac caaaccgact     1440

tacccaccga tgaatcctat tcccgccccc ctcccccctg acattccctc cttcaacctc     1500

atcggagact ccctgtcctt cgacttcaaa gacaccgata tgaagcggct gtctatggaa     1560

attgaaaagg aaaaggtcga gtacatggag aagtccaagc atctgcaaga gcaactcaac     1620

gaactcaaaa ctgagatcga agctctgaag ctgaaggaaa gagagactgc cctggacatt     1680

ctccataacg aaaactcgga caggggtggt agcagcaagc acaacaccat caagaagctg     1740

actctgcaat cggccaagag ccgcgtggca ttcttcgagg agctgtaact cgaggatta      1799


<210>  3
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  4
<211>  308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  4
acatgtcctg caggcagctg cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg       60

ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctgcg gccggtcgcg tctagttatt aatgcatact      180

agttaccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      240

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt      300

atcatatg                                                               308


<210>  5
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  5
ctcgagtaaa taacaggcct attgattgga aagtttgtca acgaattgtg ggtcttttgg       60

ggtttgctgc cccttttacg caatgtggat atcctgcttt aatgccttta tatgcatgta      120

tacaagcaaa acaggctttt actttctcgc caacttacaa ggcctttctc agtaaacagt      180

atatgaccct ttaccccgtt gctcggcaac ggcctggtct gtgccaagtg tttgctgacg      240

caacccccac tggttggggc ttggccatag gccatcagcg catgcgtgga acctttgtgt      300

ctcctctgcc gatccatact gcggaactcc tagccgcttg ttttgctcgc agcaggtctg      360

gagcaaacct catcgggacc gacaattctg tcgtactctc ccgcaagtat acatcgtttc      420

catggctgct aggctgtgct gccaactgga tcctgcgcgg gacgtccttt gtttacgtcc      480

cgtcggcgct gaatcccgcg gacgacccct cccggggccg cttggggctc taccgcccgc      540

ttctccgtct gccgtaccgt ccgaccacgg ggcgcacctc tctttacgcg gactccccgt      600

ctgtgccttc tcatctgccg gaccgtgtgc acttcgcttc acctctgcac gtcgcatgga      660

gaccaccgtg aacgcccacc ggaacctgcc caaggtcttg cataagagga ctcttggact      720

ttcagcaatg tcatcgatat c                                                741


<210>  6
<211>  412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  6
actagttaca gctctggtag cggtaaccat gcgtatttga cacacgaagg aactagggaa       60

aaggcattag gtcatttcaa gccgaaattc acatgtgcta gaatccagat tccatgctga      120

ccgatgcccc aggatataga aaatgagaat ctggtcctta ccttcaagaa cattcttaac      180

cgtaatcagc ctctggtatc ttagctccac cctcactggt tttttcttgt ttgttgaacc      240

ggccaagctg ctggcctccc tcctcaaccg ttctgatcat gcttgctaaa atagtcaaaa      300

ccccggccag ttaaatatgc tttagcctgc tttattatga ttatttttgt tgttttggca      360

atgacctggt tacctgttgt ttctcccact aaaacttttt aagggcacta gt              412


<210>  7
<211>  6898
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  7
gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc       60

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg      120

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa      180

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg      240

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg      300

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga      360

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt      420

ttacggttcc tggccttttg ctggcctttt gctcacatgt cctgcaggca gctgcgcgct      480

cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg      540

gcctcagtga gcgagcgagc gcgcagagag ggagtggcca actccatcac taggggttcc      600

tgcggccggt cgcgtctagt tattaatgca tactagttac agctctggta gcggtaacca      660

tgcgtatttg acacacgaag gaactaggga aaaggcatta ggtcatttca agccgaaatt      720

cacatgtgct agaatccaga ttccatgctg accgatgccc caggatatag aaaatgagaa      780

tctggtcctt accttcaaga acattcttaa ccgtaatcag cctctggtat cttagctcca      840

ccctcactgg ttttttcttg tttgttgaac cggccaagct gctggcctcc ctcctcaacc      900

gttctgatca tgcttgctaa aatagtcaaa accccggcca gttaaatatg ctttagcctg      960

ctttattatg attatttttg ttgttttggc aatgacctgg ttacctgttg tttctcccac     1020

taaaactttt taagggcact agttaccatt gacgtcaata atgacgtatg ttcccatagt     1080

aacgccaata gggactttcc attgacgtca atgggtggac tatttacggt aaactgccca     1140

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg     1200

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca     1260

gtacatctac gtattagtca tcgctattac catggtcgag gtgagcccca cgttctgctt     1320

cactctcccc atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt     1380

attttgtgca gcgatggggg cggggggggg gggggggcgc gcgccaggcg gggcggggcg     1440

gggcgagggg cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc     1500

gctccgaaag tttcctttta tggcgaggcg gcggcggcgg cggccctata aaaagcgaag     1560

cgcgcggcgg gcgggagtcg ctgcgacgct gccttcgccc cgtgccccgc tccgccgccg     1620

cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg agcgggcggg     1680

acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt gtttcttttc     1740

tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg gggagcggct     1800

cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc     1860

ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt     1920

ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa     1980

ttggatcggt accagccacc atggccggcg cgattgcttc ccggatgtca ttctcctcac     2040

ttaaaagaaa acagcctaag acttttaccg tgcggatcgt gactatggat gcagagatgg     2100

aattcaactg cgagatgaag tggaagggaa aggacctctt cgacctcgtc tgtcgcacct     2160

tgggactgcg ggaaacctgg ttcttcggac tgcagtacac aatcaaggac accgtggcct     2220

ggctgaaaat ggacaagaag gtcctggacc acgacgtgtc caaggaagaa cccgtgactt     2280

tccactttct ggccaagttc tacccggaga acgctgagga agaactcgtg caggagatca     2340

ctcagcatct gttcttttta caagtcaaga agcaaatcct agatgagaag atctactgcc     2400

cgccggaagc gtccgtgctt ctggcttcct acgcggtgca ggccaaatat ggagactacg     2460

atccctccgt gcacaagcgc gggttcctgg cccaagagga actgctgcct aagcgcgtga     2520

tcaacctgta ccagatgacc cccgagatgt gggaggaacg aattacggct tggtacgcgg     2580

agcatcgcgg cagagcacgc gatgaagccg agatggagta cctgaagatc gcgcaggatc     2640

ttgagatgta cggggtcaac tatttcgcca tccgcaacaa gaagggcacc gaactcctgc     2700

ttggagtgga cgcactcggg ctccacatct acgacccgga aaaccgcctg actcccaaga     2760

tcagcttccc ttggaacgaa atcagaaaca tttcctactc ggataaggaa ttcacgatca     2820

agccactgga caaaaagatt gacgtgttca agttcaactc gtcgaagctg cgcgtgaaca     2880

agctgatact gcaactgtgc attggcaatc acgacctgtt tatgcgccgg cggaaggccg     2940

actcattgga ggtccaacag atgaaggccc aggcccgcga ggaaaaggct cgcaagcaga     3000

tggaacggca gaggctggcc agagagaagc agatgcggga agaggccgaa cgcacccggg     3060

atgaactgga gcgcaggctg ctgcagatga aggaagaagc aaccatggcc aacgaagcgc     3120

tgatgcggag cgaagaaacc gcggacctgt tggccgaaaa ggctcagatc accgaggaag     3180

aagccaagct ccttgcgcaa aaggccgccg aggccgaaca ggagatgcag agaatcaagg     3240

ccaccgccat cagaaccgaa gaagagaagc ggctcatgga acagaaagtg ttggaagccg     3300

aggtgctggc gcttaagatg gcagaggagt ccgagagaag ggccaaagag gcagaccagc     3360

tgaagcagga tctgcaggaa gcccgggaag ccgagcggcg ggcgaagcag aagctcttgg     3420

aaatcgccac caaaccgact tacccaccga tgaatcctat tcccgccccc ctcccccctg     3480

acattccctc cttcaacctc atcggagact ccctgtcctt cgacttcaaa gacaccgata     3540

tgaagcggct gtctatggaa attgaaaagg aaaaggtcga gtacatggag aagtccaagc     3600

atctgcaaga gcaactcaac gaactcaaaa ctgagatcga agctctgaag ctgaaggaaa     3660

gagagactgc cctggacatt ctccataacg aaaactcgga caggggtggt agcagcaagc     3720

acaacaccat caagaagctg actctgcaat cggccaagag ccgcgtggca ttcttcgagg     3780

agctgtaact cgagtaaata acaggcctat tgattggaaa gtttgtcaac gaattgtggg     3840

tcttttgggg tttgctgccc cttttacgca atgtggatat cctgctttaa tgcctttata     3900

tgcatgtata caagcaaaac aggcttttac tttctcgcca acttacaagg cctttctcag     3960

taaacagtat atgacccttt accccgttgc tcggcaacgg cctggtctgt gccaagtgtt     4020

tgctgacgca acccccactg gttggggctt ggccataggc catcagcgca tgcgtggaac     4080

ctttgtgtct cctctgccga tccatactgc ggaactccta gccgcttgtt ttgctcgcag     4140

caggtctgga gcaaacctca tcgggaccga caattctgtc gtactctccc gcaagtatac     4200

atcgtttcca tggctgctag gctgtgctgc caactggatc ctgcgcggga cgtcctttgt     4260

ttacgtcccg tcggcgctga atcccgcgga cgacccctcc cggggccgct tggggctcta     4320

ccgcccgctt ctccgtctgc cgtaccgtcc gaccacgggg cgcacctctc tttacgcgga     4380

ctccccgtct gtgccttctc atctgccgga ccgtgtgcac ttcgcttcac ctctgcacgt     4440

cgcatggaga ccaccgtgaa cgcccaccgg aacctgccca aggtcttgca taagaggact     4500

cttggacttt cagcaatgtc atcgatatcc gatccaccgg atctagataa ctgatcataa     4560

tcagccatac cacatttgta gaggttttac ttgctttaaa aaacctccca cacctccccc     4620

tgaacctgaa acataaaatg aatgcaattg ttgttgttaa cttgtttatt gcagcttata     4680

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     4740

attctagttg tggtttgtcc aaactcatca atgtatctta acgcggtaac cacgtgcgga     4800

cccaacggcc gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4860

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4920

cagtgagcga gcgagcgcgc agctgcctgc aggggcgcct gatgcggtat tttctcctta     4980

cgcatctgtg cggtatttca caccgcatac gtcaaagcaa ccatagtacg cgccctgtag     5040

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     5100

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     5160

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     5220

cctcgacccc aaaaaacttg atttgggtga tggttcacgt agtgggccat cgccctgata     5280

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     5340

aactggaaca acactcaacc ctatctcggg ctattctttt gatttataag ggattttgcc     5400

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     5460

caaaatatta acgtttacaa ttttatggtg cactctcagt acaatctgct ctgatgccgc     5520

atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     5580

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     5640

gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt     5700

ataggttaat gtcatgacgc ggaaccccta tttgtttatt tttctaaata cattcaaata     5760

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     5820

gtatgagcca tattcaacgg gaaacgtcga ggccgcgatt aaattccaac atggatgctg     5880

atttatatgg gtataaatgg gctcgcgata atgtcgggca atcaggtgcg acaatctatc     5940

gcttgtatgg gaagcccgat gcgccagagt tgtttctgaa acatggcaaa ggtagcgttg     6000

ccaatgatgt tacagatgag atggtcagac taaactggct gacggaattt atgcctcttc     6060

cgaccatcaa gcattttatc cgtactcctg atgatgcatg gttactcacc actgcgatcc     6120

ccggaaaaac agcattccag gtattagaag aatatcctga ttcaggtgaa aatattgttg     6180

atgcgctggc agtgttcctg cgccggttgc attcgattcc tgtttgtaat tgtcctttta     6240

acagcgatcg cgtatttcgt ctcgctcagg cgcaatcacg aatgaataac ggtttggttg     6300

atgcgagtga ttttgatgac gagcgtaatg gctggcctgt tgaacaagtc tggaaagaaa     6360

tgcataaact tttgccattc tcaccggatt cagtcgtcac tcatggtgat ttctcacttg     6420

ataaccttat ttttgacgag gggaaattaa taggttgtat tgatgttgga cgagtcggaa     6480

tcgcagaccg ataccaggat cttgccatcc tatggaactg cctcggtgag ttttctcctt     6540

cattacagaa acggcttttt caaaaatatg gtattgataa tcctgatatg aataaattgc     6600

agtttcattt gatgctcgat gagtttttct aatcatgacc aaaatccctt aacgtgagtt     6660

ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt     6720

ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg     6780

tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca     6840

gataccaaat actgttcttc tagtgtagcc gtagttaggc caccacttca agaactct       6898


<210>  8
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  8

Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 
1               5                   10                  15      


Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 
            20                  25                  30          


Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 
        35                  40                  45              


Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 
    50                  55                  60                  


Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 
65                  70                  75                  80  


Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 
                85                  90                  95      


Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 
            100                 105                 110         


Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 
        115                 120                 125             


Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 
145                 150                 155                 160 


Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 
                165                 170                 175     


Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 
            180                 185                 190         


Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 
        195                 200                 205             


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 
    210                 215                 220                 


Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 
225                 230                 235                 240 


Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 
                245                 250                 255     


Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 
            260                 265                 270         


Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 
        275                 280                 285             


Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 
    290                 295                 300                 


Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 
305                 310                 315                 320 


Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 
                325                 330                 335     


Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 
            340                 345                 350         


Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 
        355                 360                 365             


Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 
    370                 375                 380                 


Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 
385                 390                 395                 400 


Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 
                405                 410                 415     


Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 
            420                 425                 430         


Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 
        435                 440                 445             


Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 
    450                 455                 460                 


Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 
465                 470                 475                 480 


Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 
                485                 490                 495     


Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 
            500                 505                 510         


Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 
        515                 520                 525             


Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 
    530                 535                 540                 


Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 
545                 550                 555                 560 


Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 
                565                 570                 575     


Ile Lys Lys Pro Gln Ala Gln Gly Arg Arg Pro Ile Cys Ile 
            580                 585                 590 


<210>  9
<211>  1770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  9
atggccgggg ccatcgcttc ccgcatgagc ttcagctctc tcaagaggaa gcaacccaag       60

acgttcaccg tgaggatcgt caccatggac gccgagatgg agttcaattg cgagatgaag      120

tggaaaggga aggacctctt tgatttggtg tgccggactc tggggctccg agaaacctgg      180

ttctttggac tgcagtacac aatcaaggac acagtggcct ggctcaaaat ggacaagaag      240

gtactggatc atgatgtttc aaaggaagaa ccagtcacct ttcacttctt ggccaaattt      300

tatcctgaga atgctgaaga ggagctggtt caggagatca cacaacattt attcttctta      360

caggtaaaga agcagatttt agatgaaaag atctactgcc ctcctgaggc ttctgtgctc      420

ctggcttctt acgccgtcca ggccaagtat ggtgactacg accccagtgt tcacaagcgg      480

ggatttttgg cccaagagga attgcttcca aaaagggtaa taaatctgta tcagatgact      540

ccggaaatgt gggaggagag aattactgct tggtacgcag agcaccgagg ccgagccagg      600

gatgaagctg aaatggaata tctgaagata gctcaggacc tggagatgta cggtgtgaac      660

tactttgcaa tccggaataa aaagggcaca gagctgctgc ttggagtgga tgccctgggg      720

cttcacattt atgaccctga gaacagactg acccccaaga tctccttccc gtggaatgaa      780

atccgaaaca tctcgtacag tgacaaggag tttactatta aaccactgga taagaaaatt      840

gatgtcttca agtttaactc ctcaaagctt cgtgttaata agctgattct ccagctatgt      900

atcgggaacc atgatctatt tatgaggaga aggaaagccg attctttgga agttcagcag      960

atgaaagccc aggccaggga ggagaaggct agaaagcaga tggagcggca gcgcctcgct     1020

cgagagaagc agatgaggga ggaggctgaa cgcacgaggg atgagttgga gaggaggctg     1080

ctgcagatga aagaagaagc aacaatggcc aacgaagcac tgatgcggtc tgaggagaca     1140

gctgacctgt tggctgaaaa ggcccagatc accgaggagg aggcaaaact tctggcccag     1200

aaggccgcag aggctgagca ggaaatgcag cgcatcaagg ccacagcgat tcgcacggag     1260

gaggagaagc gcctgatgga gcagaaggtg ctggaagccg aggtgctggc actgaagatg     1320

gctgaggagt cagagaggag ggccaaagag gcagatcagc tgaagcagga cctgcaggaa     1380

gcacgcgagg cggagcgaag agccaagcag aagctcctgg agattgccac caagcccacg     1440

tacccgccca tgaacccaat tccagcaccg ttgcctcctg acataccaag cttcaacctc     1500

attggtgaca gcctgtcttt cgacttcaaa gatactgaca tgaagcggct ttccatggag     1560

atagagaaag aaaaagtgga atacatggaa aagagcaagc atctgcagga gcagctcaat     1620

gaactcaaga cagaaatcga ggccttgaaa ctgaaagaga gggagacagc tctggatatt     1680

ctgcacaatg agaactccga caggggtggc agcagcaagc acaataccat taaaaagcct     1740

caagcccaag gcagaagacc tatctgcatt                                      1770


