                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       MO, Chia Hoa
 
<120>  PHOTOACTIVATABLE GASDERMIN PROTEINS

<130>  UIC0098WO

<150>  US 63/197,672
<151>  2021-06-07

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Met Phe Glu Asn Val Thr Arg Ala Leu Ala Arg Gln Leu Asn 
1               5                   10                  15      


Pro Arg Gly Asp Leu Thr Pro Leu Asp Ser Leu Ile Asp Phe Lys Arg 
            20                  25                  30          


Phe His Pro Phe Cys Leu Val Leu Arg Lys Arg Lys Ser Thr Leu Phe 
        35                  40                  45              


Trp Gly Ala Arg Tyr Val Arg Thr Asp Tyr Thr Leu Leu Asp Val Leu 
    50                  55                  60                  


Glu Pro Gly Ser Ser Pro Ser Asp Pro Thr Asp Thr Gly Asn Phe Gly 
65                  70                  75                  80  


Phe Lys Asn Met Leu Asp Thr Arg Val Glu Gly Asp Val Asp Val Pro 
                85                  90                  95      


Lys Thr Val Lys Val Lys Gly Thr Ala Gly Leu Ser Gln Asn Ser Thr 
            100                 105                 110         


Leu Glu Val Gln Thr Leu Ser Val Ala Pro Lys Ala Leu Glu Thr Val 
        115                 120                 125             


Gln Glu Arg Lys Leu Ala Ala Asp His Pro Phe Leu Lys Glu Met Gln 
    130                 135                 140                 


Asp Gln Gly Glu Asn Leu Tyr Val Val Met Glu Val Val Glu Thr Val 
145                 150                 155                 160 


Gln Glu Val Thr Leu Glu Arg Ala Gly Lys Ala Glu Ala Cys Phe Ser 
                165                 170                 175     


Leu Pro Phe Phe Ala Pro Leu Gly Leu Gln Gly Ser Ile Asn His Lys 
            180                 185                 190         


Glu Ala Val Thr Ile Pro Lys Gly Cys Val Leu Ala Phe Arg Val Arg 
        195                 200                 205             


Gln Leu Met Val Lys Gly Lys Asp Glu Trp Asp Ile Pro His Ile Cys 
    210                 215                 220                 


Asn Asp Asn Met Gln Thr Phe Pro Pro Gly Glu Lys Ser Gly Glu Glu 
225                 230                 235                 240 


Lys Val Ile Leu Ile Gln Ala Ser Asp Val Gly Asp Val His Glu Gly 
                245                 250                 255     


Phe Arg Thr Leu Lys Glu Glu Val Gln Arg Glu Thr Gln Gln Val Glu 
            260                 265                 270         


Lys Leu Ser Arg Val Gly Gln Ser Ser Leu Leu Ser Ser Leu Ser Lys 
        275                 280                 285             


Leu Leu Gly Lys Lys Lys Glu Leu Gln Asp Leu Glu Leu Ala Leu Glu 
    290                 295                 300                 


Gly Ala Leu Asp Lys Gly His Glu Val Thr Leu Glu Ala Leu Pro Lys 
305                 310                 315                 320 


Asp Val Leu Leu Ser Lys Glu Ala Val Gly Ala Ile Leu Tyr Phe Val 
                325                 330                 335     


Gly Ala Leu Thr Glu Leu Ser Glu Ala Gln Gln Lys Leu Leu Val Lys 
            340                 345                 350         


Ser Met Glu Lys Lys Ile Leu Pro Val Gln Leu Lys Leu Val Glu Ser 
        355                 360                 365             


Thr Met Glu Gln Asn Phe Leu Leu Asp Lys Glu Gly Val Phe Pro Leu 
    370                 375                 380                 


Gln Pro Glu Leu Leu Ser Ser Leu Gly Asp Glu Glu Leu Thr Leu Thr 
385                 390                 395                 400 


Glu Ala Leu Val Gly Leu Ser Gly Leu Glu Val Gln Arg Ser Gly Pro 
                405                 410                 415     


Gln Tyr Met Trp Asp Pro Asp Thr Leu Pro Arg Leu Cys Ala Leu Tyr 
            420                 425                 430         


Ala Gly Leu Ser Leu Leu Gln Gln Leu Thr Lys Ala Ser 
        435                 440                 445 


<210>  2
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  2

Met Pro Val Phe Glu Asp Val Thr Arg Ala Leu Val Arg Glu Leu Asn 
1               5                   10                  15      


Pro Arg Gly Asp Leu Thr Pro Leu Asp Ser Leu Ile Asp Phe Lys His 
            20                  25                  30          


Phe Arg Pro Phe Cys Leu Val Leu Arg Lys Arg Lys Ser Thr Leu Phe 
        35                  40                  45              


Trp Gly Ala Arg Tyr Val Arg Thr Asp Tyr Thr Leu Leu Asp Leu Leu 
    50                  55                  60                  


Glu Pro Gly Ser Ser Pro Ser Asp Leu Thr Asp Ser Gly Asn Phe Ser 
65                  70                  75                  80  


Phe Lys Asn Met Leu Asp Val Gln Val Gln Gly Leu Val Glu Val Pro 
                85                  90                  95      


Lys Thr Val Lys Val Lys Gly Thr Ala Gly Leu Ser Gln Ser Ser Thr 
            100                 105                 110         


Leu Glu Val Gln Thr Leu Ser Val Ala Pro Ser Ala Leu Glu Asn Leu 
        115                 120                 125             


Lys Lys Glu Arg Lys Leu Ser Ala Asp His Ser Phe Leu Asn Glu Met 
    130                 135                 140                 


Arg Tyr His Glu Lys Asn Leu Tyr Val Val Met Glu Ala Val Glu Ala 
145                 150                 155                 160 


Lys Gln Glu Val Thr Val Glu Gln Thr Gly Asn Ala Asn Ala Ile Phe 
                165                 170                 175     


Ser Leu Pro Ser Leu Ala Leu Leu Gly Leu Gln Gly Ser Leu Asn Asn 
            180                 185                 190         


Asn Lys Ala Val Thr Ile Pro Lys Gly Cys Val Leu Ala Tyr Arg Val 
        195                 200                 205             


Arg Leu Leu Arg Val Phe Leu Phe Asn Leu Trp Asp Ile Pro Tyr Ile 
    210                 215                 220                 


Cys Asn Asp Ser Met Gln Thr Phe Pro Lys Ile Arg Arg Val Pro Cys 
225                 230                 235                 240 


Ser Ala Phe Ile Ser Pro Thr Gln Met Ile Ser Glu Glu Pro Glu Glu 
                245                 250                 255     


Glu Lys Leu Ile Gly Glu Met His Glu Asp Phe Lys Thr Leu Lys Glu 
            260                 265                 270         


Glu Val Gln Arg Glu Thr Gln Glu Val Glu Lys Leu Ser Pro Val Gly 
        275                 280                 285             


Arg Ser Ser Leu Leu Thr Ser Leu Ser His Leu Leu Gly Lys Lys Lys 
    290                 295                 300                 


Glu Leu Gln Asp Leu Glu Gln Lys Leu Glu Gly Ala Leu Asp Lys Gly 
305                 310                 315                 320 


Gln Lys Val Thr Leu Glu Ala Leu Pro Lys Asp Val Leu Leu Ser Lys 
                325                 330                 335     


Asp Ala Met Asp Ala Ile Leu Tyr Phe Leu Gly Ala Leu Thr Glu Leu 
            340                 345                 350         


Thr Glu Glu Gln Leu Lys Ile Leu Val Lys Ser Leu Glu Lys Lys Ile 
        355                 360                 365             


Leu Pro Val Gln Leu Lys Leu Val Glu Ser Thr Leu Glu Gln Asn Phe 
    370                 375                 380                 


Leu Gln Asp Lys Glu Gly Val Phe Pro Leu Gln Pro Asp Leu Leu Ser 
385                 390                 395                 400 


Ser Leu Gly Glu Glu Glu Leu Thr Leu Thr Glu Ala Leu Val Gly Leu 
                405                 410                 415     


Ser Gly Leu Glu Val Gln Arg Ser Gly Pro Gln Tyr Ala Trp Asp Pro 
            420                 425                 430         


Asp Thr Arg His Asn Leu Cys Ala Leu Tyr Ala Gly Leu Ser Leu Leu 
        435                 440                 445             


His Leu Leu Ser Arg Lys Ser Asn Ala Leu Thr Tyr Cys Ala Leu Ser 
    450                 455                 460                 


<210>  3
<211>  446
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Thr Met Phe Glu Asn Val Thr Arg Ala Leu Ala Arg Gln Leu Asn 
1               5                   10                  15      


Pro Arg Gly Asp Leu Thr Pro Leu Asp Ser Leu Ile Asp Phe Lys Cys 
            20                  25                  30          


Phe His Pro Phe Cys Leu Val Leu Arg Lys Arg Lys Ser Thr Leu Phe 
        35                  40                  45              


Trp Gly Ala Arg Tyr Val Arg Thr Asp Tyr Thr Leu Leu Asp Leu Leu 
    50                  55                  60                  


Glu Pro Gly Asn Thr Pro Ser Asp Pro Thr Asp Gly Gly Asn Phe Ser 
65                  70                  75                  80  


Phe Lys Asn Met Leu Asp Ala Arg Val Glu Gly Asp Val Asp Val Pro 
                85                  90                  95      


Lys Thr Val Lys Val Lys Gly Thr Ala Gly Leu Ser Gln Ser Ser Thr 
            100                 105                 110         


Leu Glu Val Gln Thr Leu Ser Val Ala Pro Lys Ala Leu Glu Ser Leu 
        115                 120                 125             


His Lys Glu Arg Lys Leu Ser Ala Asp His Pro Phe Leu Lys Glu Met 
    130                 135                 140                 


Trp Glu Arg Gly Glu Asn Leu Tyr Val Val Met Glu Val Val Glu Thr 
145                 150                 155                 160 


Val Gln Glu Val Thr Leu Glu Arg Ala Gly Lys Ala Glu Gly Cys Phe 
                165                 170                 175     


Ser Leu Pro Phe Phe Ala Pro Leu Gly Leu Gln Gly Ser Leu Asn His 
            180                 185                 190         


Lys Glu Ala Val Thr Ile Pro Lys Gly Cys Val Leu Ala Tyr Arg Val 
        195                 200                 205             


Arg Gln Leu Met Val Asn Gly Lys Asp Glu Trp Asp Ile Pro His Val 
    210                 215                 220                 


Tyr Asn Asp Ser Met Gln Thr Phe Pro Pro Gly Glu Lys Pro Gly Glu 
225                 230                 235                 240 


Gly Lys Phe Ile Leu Ile Gln Ala Ser Asp Val Gly Glu Met His Asp 
                245                 250                 255     


Asp Phe Lys Thr Leu Lys Glu Glu Val Arg Arg Glu Thr Arg Glu Ile 
            260                 265                 270         


Glu Lys Leu Ser Gln Val Gly Arg Ser Ser Leu Leu Thr Ser Leu Arg 
        275                 280                 285             


His Leu Leu Gly Lys Lys Lys Glu Leu Gln Asp Leu Glu His Thr Leu 
    290                 295                 300                 


Glu Gly Ala Leu Asp Lys Gly His Glu Val Thr Leu Glu Ala Leu Pro 
305                 310                 315                 320 


Lys Asp Val Leu Leu Ser Lys Asp Ala Met Asp Ala Ile Leu Tyr Phe 
                325                 330                 335     


Leu Gly Ala Leu Thr Val Leu Ser Glu Ala Gln Gln Lys Leu Leu Val 
            340                 345                 350         


Lys Ser Leu Glu Lys Glu Ile Leu Pro Leu Gln Leu Lys Leu Val Glu 
        355                 360                 365             


Ser Thr Leu Glu Gln Asn Phe Leu Gln Asp Lys Glu Gly Val Phe Pro 
    370                 375                 380                 


Leu Arg Pro Asp Leu Leu Ser Ser Leu Gly Glu Glu Glu Leu Thr Leu 
385                 390                 395                 400 


Thr Glu Ala Leu Val Gly Leu Ser Gly Leu Glu Val Gln Arg Ser Gly 
                405                 410                 415     


Pro Gln Tyr Thr Trp Asp Pro Asp Thr Leu Pro His Leu Cys Ala Leu 
            420                 425                 430         


Tyr Ala Gly Leu Ser Leu Leu Gln Leu Leu Ser Met Gly Ser 
        435                 440                 445     


<210>  4
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Phe Ser Val Phe Glu Glu Ile Thr Arg Ile Val Val Lys Glu Met 
1               5                   10                  15      


Asp Ala Gly Gly Asp Met Ile Ala Val Arg Ser Leu Val Asp Ala Asp 
            20                  25                  30          


Arg Phe Arg Cys Phe His Leu Val Gly Glu Lys Arg Thr Phe Phe Gly 
        35                  40                  45              


Cys Arg His Tyr Thr Thr Gly Leu Thr Leu Met Asp Ile Leu Asp Thr 
    50                  55                  60                  


Asp Gly Asp Lys Trp Leu Asp Glu Leu Asp Ser Gly Leu Gln Gly Gln 
65                  70                  75                  80  


Lys Ala Glu Phe Gln Ile Leu Asp Asn Val Asp Ser Thr Gly Glu Leu 
                85                  90                  95      


Ile Val Arg Leu Pro Lys Glu Ile Thr Ile Ser Gly Ser Phe Gln Gly 
            100                 105                 110         


Phe His His Gln Lys Ile Lys Ile Ser Glu Asn Arg Ile Ser Gln Gln 
        115                 120                 125             


Tyr Leu Ala Thr Leu Glu Asn Arg Lys Leu Lys Arg Glu Leu Pro Phe 
    130                 135                 140                 


Ser Phe Arg Ser Ile Asn Thr Arg Glu Asn Leu Tyr Leu Val Thr Glu 
145                 150                 155                 160 


Thr Leu Glu Thr Val Lys Glu Glu Thr Leu Lys Ser Asp Arg Gln Tyr 
                165                 170                 175     


Lys Phe Trp Ser Gln Ile Ser Gln Gly His Leu Ser Tyr Lys His Lys 
            180                 185                 190         


Gly Gln Arg Glu Val Thr Ile Pro Pro Asn Arg Val Leu Ser Tyr Arg 
        195                 200                 205             


Val Lys Gln Leu Val Phe Pro Asn Lys Glu Thr Met Ser Ala Gly Leu 
    210                 215                 220                 


Asp Ile His Phe Arg Gly Lys Thr Lys Ser Phe Pro Glu Gly Lys Ser 
225                 230                 235                 240 


Leu Gly Ser Glu Asp Ser Arg Asn Met Lys Glu Lys Leu Glu Asp Met 
                245                 250                 255     


Glu Ser Val Leu Lys Asp Leu Thr Glu Glu Lys Arg Lys Asp Val Leu 
            260                 265                 270         


Asn Ser Leu Ala Lys Cys Leu Gly Lys Glu Asp Ile Arg Gln Asp Leu 
        275                 280                 285             


Glu Gln Arg Val Ser Glu Val Leu Ile Ser Gly Glu Leu His Met Glu 
    290                 295                 300                 


Asp Pro Asp Lys Pro Leu Leu Ser Ser Leu Phe Asn Ala Ala Gly Val 
305                 310                 315                 320 


Leu Val Glu Ala Arg Ala Lys Ala Ile Leu Asp Phe Leu Asp Ala Leu 
                325                 330                 335     


Leu Glu Leu Ser Glu Glu Gln Gln Phe Val Ala Glu Ala Leu Glu Lys 
            340                 345                 350         


Gly Thr Leu Pro Leu Leu Lys Asp Gln Val Lys Ser Val Met Glu Gln 
        355                 360                 365             


Asn Trp Asp Glu Leu Ala Ser Ser Pro Pro Asp Met Asp Tyr Asp Pro 
    370                 375                 380                 


Glu Ala Arg Ile Leu Cys Ala Leu Tyr Val Val Val Ser Ile Leu Leu 
385                 390                 395                 400 


Glu Leu Ala Glu Gly Pro Thr Ser Val Ser Ser 
                405                 410     


<210>  5
<211>  443
<212>  PRT
<213>  Bos taurus

<400>  5

Met Pro Thr Val Phe Glu Ser Ile Ser Arg Ala Val Val Lys Glu Ile 
1               5                   10                  15      


Asp Thr Ser Gly Glu Thr Ile Ala Val Arg Ser Leu Ser Asp Ala Asp 
            20                  25                  30          


Lys Phe His Cys Ser Tyr Leu Val Lys Lys Arg Arg Arg Phe Phe Gly 
        35                  40                  45              


Tyr Gln Tyr Asp Lys Thr Asn Leu Thr Leu Lys Asp Ile Leu Glu Cys 
    50                  55                  60                  


Glu Val Pro Phe Asp Met Val Val Pro Glu Leu Gln Gly Asp Leu Pro 
65                  70                  75                  80  


Asp Ser Gly Ile Lys Pro Ala Ser Ala Ala Leu Pro Glu Asp Ser Leu 
                85                  90                  95      


Pro Leu Ser His Leu Gly Asn Pro His Asn Lys Gly Gln Gly Asp Asn 
            100                 105                 110         


Phe Glu Ile Leu Asp Val Val Asp Ser Lys Gly Ser Leu Ala Val Lys 
        115                 120                 125             


Phe His Pro Gln Met Thr Phe Lys Ile Ala Phe His Ile Phe Gln Glu 
    130                 135                 140                 


Lys Asn Ile Lys Leu Glu Lys Ser Glu Ile Pro Gln Glu Phe Leu Asp 
145                 150                 155                 160 


Ser Leu Lys Asn Lys Lys Leu Lys Lys Glu Leu Pro Pro Ser Phe Gln 
                165                 170                 175     


Ser Ile Gln Ala Lys Arg Glu Asp Leu Tyr Leu Val Thr Glu Thr Leu 
            180                 185                 190         


Lys Thr Lys Arg Thr Glu Thr Leu Lys Tyr Glu Thr Gln Phe Gly Phe 
        195                 200                 205             


Gln Ile Leu Leu Lys Met Phe Gly Phe Gln Cys Lys His Lys His Gln 
    210                 215                 220                 


Lys Glu Val Thr Ile Thr Pro Glu Lys Val Leu Ala Tyr Arg Val Lys 
225                 230                 235                 240 


Gln Leu Val Phe Pro Ser Ala Glu Arg Met Asp Ile Cys Phe Leu Asp 
                245                 250                 255     


Lys Thr Arg Ser Phe Pro Glu Glu Lys Asp Gly Gly Ser Ser Trp Leu 
            260                 265                 270         


Gly Lys Ser Leu Asn Leu Glu Asn Phe Arg Ser Ile Lys Glu Arg Val 
        275                 280                 285             


Gln Asp Met Val Arg Val Leu Gln Asp Leu Thr Pro Glu Glu Gln Lys 
    290                 295                 300                 


Glu Ala Leu Asn Cys Phe Thr Lys Cys Leu Ser Ser Glu Glu Glu Leu 
305                 310                 315                 320 


Gln Asp Leu Glu Gln Arg Val Ser Glu Val Gln Cys Ser Gly Glu Leu 
                325                 330                 335     


Gln Met Asn Ser Pro Ala Asn Ser Leu Ile Ser Ser Leu Phe Asn Ala 
            340                 345                 350         


Ala Gly Ala Leu Ile Glu Ala Arg Ala Glu Thr Ile Trp Asp Val Leu 
        355                 360                 365             


Asp Ala Leu Met Glu Leu Ser Glu Tyr Arg Gln Phe Val Ala Glu Val 
    370                 375                 380                 


Leu Asp Lys Gly Glu Leu Arg Pro Val Lys Asp Lys Val Glu Ser Ile 
385                 390                 395                 400 


Leu Glu Glu Asn Arg Cys Glu Gly Pro Leu Asp Val Ser Cys Asp Pro 
                405                 410                 415     


Glu Ala Arg Thr Leu Cys Ala Leu Tyr Val Val Val Ser Ile Leu Leu 
            420                 425                 430         


Gln Leu Ser Glu Lys Pro Thr Ser Val Ser Ser 
        435                 440             


<210>  6
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ser Met Leu Glu Arg Ile Ser Lys Asn Leu Val Lys Glu Ile 
1               5                   10                  15      


Gly Ser Lys Asp Leu Thr Pro Val Lys Tyr Leu Leu Ser Ala Thr Lys 
            20                  25                  30          


Leu Arg Gln Phe Val Ile Leu Arg Lys Lys Lys Asp Ser Arg Ser Ser 
        35                  40                  45              


Phe Trp Glu Gln Ser Asp Tyr Val Pro Val Glu Phe Ser Leu Asn Asp 
    50                  55                  60                  


Ile Leu Glu Pro Ser Ser Ser Val Leu Glu Thr Val Val Thr Gly Pro 
65                  70                  75                  80  


Phe His Phe Ser Asp Ile Met Ile Gln Lys His Lys Ala Asp Met Gly 
                85                  90                  95      


Val Asn Val Gly Ile Glu Val Ser Val Ser Gly Glu Ala Ser Val Asp 
            100                 105                 110         


His Gly Cys Ser Leu Glu Phe Gln Ile Val Thr Ile Pro Ser Pro Asn 
        115                 120                 125             


Leu Glu Asp Phe Gln Lys Arg Lys Leu Leu Asp Pro Glu Pro Ser Phe 
    130                 135                 140                 


Leu Lys Glu Cys Arg Arg Arg Gly Asp Asn Leu Tyr Val Val Thr Glu 
145                 150                 155                 160 


Ala Val Glu Leu Ile Asn Asn Thr Val Leu Tyr Asp Ser Ser Ser Val 
                165                 170                 175     


Asn Ile Leu Gly Lys Ile Ala Leu Trp Ile Thr Tyr Gly Lys Gly Gln 
            180                 185                 190         


Gly Gln Gly Glu Ser Leu Arg Val Lys Lys Lys Ala Leu Thr Leu Gln 
        195                 200                 205             


Lys Gly Met Val Met Ala Tyr Lys Arg Lys Gln Leu Val Ile Lys Glu 
    210                 215                 220                 


Lys Ala Ile Leu Ile Ser Asp Asp Asp Glu Gln Arg Thr Phe Gln Asp 
225                 230                 235                 240 


Glu Tyr Glu Ile Ser Glu Met Val Gly Tyr Cys Ala Ala Arg Ser Glu 
                245                 250                 255     


Gly Leu Leu Pro Ser Phe His Thr Ile Ser Pro Thr Leu Phe Asn Ala 
            260                 265                 270         


Ser Ser Asn Asp Met Lys Leu Lys Pro Glu Leu Phe Leu Thr Gln Gln 
        275                 280                 285             


Phe Leu Ser Gly His Leu Pro Lys Tyr Glu Gln Val His Ile Leu Pro 
    290                 295                 300                 


Val Gly Arg Ile Glu Glu Pro Phe Trp Gln Asn Phe Lys His Leu Gln 
305                 310                 315                 320 


Glu Glu Val Phe Gln Lys Ile Lys Thr Leu Ala Gln Leu Ser Lys Asp 
                325                 330                 335     


Val Gln Asp Val Met Phe Tyr Ser Ile Leu Ala Met Leu Arg Asp Arg 
            340                 345                 350         


Gly Ala Leu Gln Asp Leu Met Asn Met Leu Glu Leu Asp Ser Ser Gly 
        355                 360                 365             


His Leu Asp Gly Pro Gly Gly Ala Ile Leu Lys Lys Leu Gln Gln Asp 
    370                 375                 380                 


Ser Asn His Ala Trp Phe Asn Pro Lys Asp Pro Ile Leu Tyr Leu Leu 
385                 390                 395                 400 


Glu Ala Ile Met Val Leu Ser Asp Phe Gln His Asp Leu Leu Ala Cys 
                405                 410                 415     


Ser Met Glu Lys Arg Ile Leu Leu Gln Gln Gln Glu Leu Val Arg Ser 
            420                 425                 430         


Ile Leu Glu Pro Asn Phe Arg Tyr Pro Trp Ser Ile Pro Phe Thr Leu 
        435                 440                 445             


Lys Pro Glu Leu Leu Ala Pro Leu Gln Ser Glu Gly Leu Ala Ile Thr 
    450                 455                 460                 


Tyr Gly Leu Leu Glu Glu Cys Gly Leu Arg Met Glu Leu Asp Asn Pro 
465                 470                 475                 480 


Arg Ser Thr Trp Asp Val Glu Ala Lys Met Pro Leu Ser Ala Leu Tyr 
                485                 490                 495     


Gly Thr Leu Ser Leu Leu Gln Gln Leu Ala Glu Ala 
            500                 505             


<210>  7
<211>  468
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ser Tyr Thr Phe Asp Trp Leu Ser Lys Asp Val Val Lys Lys Leu 
1               5                   10                  15      


Gln Gly Arg Asp Leu Arg Pro Val Lys Cys Leu Ser Asp Ala Thr Lys 
            20                  25                  30          


Phe Cys Leu Phe Asn Ile Leu Gln Glu Thr Ser Ser Arg Leu Ala Leu 
        35                  40                  45              


Lys Thr Glu Tyr Ile Pro Val Gly Phe Thr Leu Leu His Leu Leu Glu 
    50                  55                  60                  


Pro Asn Ile Pro Val Pro Glu Pro Glu Val Ser Ala Pro Ile Pro Leu 
65                  70                  75                  80  


Lys His Thr Ile Ser Gln Lys Leu Lys Ala Asp Leu Asp Val Glu Thr 
                85                  90                  95      


Ile Ala Gly Gly Glu Ala Gly Phe Val Lys Ser Cys Gly Tyr Asp Ile 
            100                 105                 110         


Glu Val Gln Ser Lys Ser Ile Pro Asn Pro Lys Leu Glu Ser Leu Gln 
        115                 120                 125             


Asn Arg Lys Leu Leu Asp Gln Leu Pro Thr Phe Met Lys Thr Cys Trp 
    130                 135                 140                 


Lys Asp Gly Lys Asn Leu Tyr Val Val Thr Glu Ala Tyr Glu Val Thr 
145                 150                 155                 160 


Lys Asp Thr Val Leu Glu Gly Thr Ser Asn Ser Lys Phe Ala Ile Lys 
                165                 170                 175     


Gly Ile Ile Asn Gln Leu Val Lys Val Gly Gly Ser Gly Gln Trp Gln 
            180                 185                 190         


Thr Glu Lys Thr Asp Ser Ile Pro Ile Gln Lys Gly Ser Val Leu Ala 
        195                 200                 205             


Tyr Lys Lys Gln Gln Leu Val Ile Glu Asp Asn Thr Cys Val Ile Leu 
    210                 215                 220                 


Thr Ser Ala Asn Thr Lys Lys Lys Met Thr Phe Pro Met Arg Phe Val 
225                 230                 235                 240 


Gly Met Ser Gly His Leu Arg Tyr Gln Asp Leu Val Ile Glu Thr Gly 
                245                 250                 255     


Ser Trp Ile Asn Asp Ile Asp Pro Ile Gly Thr Ile Lys Glu Pro Thr 
            260                 265                 270         


His Leu Asp Phe Met Cys Leu Gln Asn Glu Val Ser Glu Gln Thr Arg 
        275                 280                 285             


Leu Leu Ala Glu Leu Ser Lys Asp Val Gln Glu Val Val Phe Ser Ser 
    290                 295                 300                 


Phe Leu His Met Leu Cys Asp Arg Asp Val Leu Tyr Asp Leu Met Lys 
305                 310                 315                 320 


Met Leu Glu Leu Asn Gln Leu Gly His Met Asp Gly Pro Gly Gly Lys 
                325                 330                 335     


Ile Leu Asp Glu Leu Arg Lys Asp Ser Ser Leu Ser Trp Ile Asn Leu 
            340                 345                 350         


Lys Asp Leu Ile Leu Tyr Leu Leu Gln Ala Leu Met Val Leu Ser Asp 
        355                 360                 365             


Thr Gln Leu Cys Leu Leu Ala Leu Ser Val Glu Met Arg Leu Leu Pro 
    370                 375                 380                 


His Gln Val Glu Leu Val Lys Ser Ile Leu Gln Pro Asn Phe Lys Tyr 
385                 390                 395                 400 


Pro Trp Asn Ile Pro Phe Thr Leu Gln Pro Gln Leu Leu Ala Pro Leu 
                405                 410                 415     


Gln Gly Glu Gly Leu Ala Ile Thr Tyr Glu Leu Leu Glu Glu Cys Gly 
            420                 425                 430         


Leu Lys Met Glu Leu Asn Asn Pro Arg Ser Thr Trp Asp Leu Glu Ala 
        435                 440                 445             


Lys Met Pro Leu Ser Ala Leu Tyr Gly Ser Leu Ser Phe Leu Gln Gln 
    450                 455                 460                 


Leu Ser Glu Ala 
465             


<210>  8
<211>  467
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Leu Tyr Thr Phe Asp Gln Val Ser Lys Asp Val Val Lys Lys Leu 
1               5                   10                  15      


Gln Gly Lys Asp Leu Arg Pro Val Arg Cys Leu Ser Asp Ala Thr Lys 
            20                  25                  30          


Phe Arg Gln Phe Asp Ile Leu Gln Lys Thr Pro Gln Ser Leu Phe Phe 
        35                  40                  45              


Lys Ser Glu Asp Thr Pro Val Gly Tyr Ser Leu Leu Gln Ile Leu Glu 
    50                  55                  60                  


Pro Asn Phe Pro Val Pro Glu Thr Glu Val Ser Ala Pro Met Pro Leu 
65                  70                  75                  80  


Lys His Ile Thr Ser Gln Lys Trp Lys Ala Asp Val Asp Val Lys Ala 
                85                  90                  95      


Thr Ile Ala Asp Gly Gly Ala Ser Ala Glu Phe Val Gln Ser Cys Gly 
            100                 105                 110         


Tyr Asp Ile Glu Val Gln Ser Arg Ser Ile Pro Asp Ser Lys Leu Glu 
        115                 120                 125             


Ser Leu Gln Asn Arg Lys Leu Leu Asp Lys Lys Leu Ser Phe Val Thr 
    130                 135                 140                 


Asp Cys Gln Met Gly Arg Asn Asn Leu Tyr Val Val Thr Glu Val Phe 
145                 150                 155                 160 


Glu Val Thr Lys Asp Thr Val Val Gln Gly Ser Ser Ser Ile Asp Leu 
                165                 170                 175     


Ser Gly Lys Ala Leu Val Ser Gln Leu Val Lys Gly Glu Ala Gln Gly 
            180                 185                 190         


Gln Trp Gln Arg Glu Thr Thr Asp Leu Val Pro Ile Pro Lys Gly Ala 
        195                 200                 205             


Val Leu Ala Tyr Lys Lys Lys Gln Leu Val Ile Glu Asn Asn Thr Cys 
    210                 215                 220                 


Ala Ile Leu Leu Ser Ala Asn Ala Lys Lys Lys Thr Phe Pro Gly Ile 
225                 230                 235                 240 


Phe Asn Phe Gly Met Ser Ser Arg Ser Gln Thr Met Glu Ile Gly Ser 
                245                 250                 255     


Trp Ile Asp Tyr Ile Pro Pro Ile Gly Arg Ile Glu Glu Pro Val His 
            260                 265                 270         


Leu Asp Phe Lys Tyr Leu Glu Lys Glu Val Phe Leu Arg Lys Glu Gln 
        275                 280                 285             


Leu Ala Met Leu Ser Lys Asp Val Gln Asp Val Val Phe Ser Asn Leu 
    290                 295                 300                 


Leu Pro Met Leu Ser Asp Ser Asp Val Leu Phe Asp Leu Ile Asn Met 
305                 310                 315                 320 


Leu Glu Leu Asp Gln Leu Gly His Met Asp Gly Pro Ala Gly Leu Ile 
                325                 330                 335     


Leu Asp Glu Leu Arg Lys Asn Ser Ser Thr Pro Trp Ile Asp Leu Lys 
            340                 345                 350         


Gly Leu Ile Leu Tyr Leu Leu Gln Ala Leu Met Val Leu Ser Asp Thr 
        355                 360                 365             


Gln Leu Asp Leu Leu Ala Gln Ser Met Glu Met Arg Ile Leu Leu Gln 
    370                 375                 380                 


Gln Arg Glu Leu Val Arg Ser Ile Leu Glu Pro Asn Phe Lys Tyr Pro 
385                 390                 395                 400 


Trp Asn Ile Pro Phe Thr Leu Gln Pro Gln Leu Leu Ala Pro Leu Gln 
                405                 410                 415     


Gly Glu Gly Leu Ala Ile Thr Tyr Glu Leu Leu Lys Gly Cys Gly Leu 
            420                 425                 430         


Lys Met Glu Pro Asn Ser Pro Arg Ser Thr Trp Asp Leu Glu Ala Lys 
        435                 440                 445             


Met Pro Leu Ser Ala Leu Tyr Gly Ile Leu Ser Cys Leu Gln Gln Leu 
    450                 455                 460                 


Val Glu Ala 
465         


<210>  9
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         


Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln 
        275                 280                 285             


Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu 
    290                 295                 300                 


Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu 
305                 310                 315                 320 


Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly 
                325                 330                 335     


Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val 
            340                 345                 350         


Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala 
        355                 360                 365             


Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr 
    370                 375                 380                 


Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly 
385                 390                 395                 400 


Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln 
                405                 410                 415     


Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp 
            420                 425                 430         


Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu 
        435                 440                 445             


Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly 
    450                 455                 460                 


Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Gln Glu Pro His 
                


<210>  10
<211>  487
<212>  PRT
<213>  Mus musculus

<400>  10

Met Pro Ser Ala Phe Glu Lys Val Val Lys Asn Val Ile Lys Glu Val 
1               5                   10                  15      


Ser Gly Ser Arg Gly Asp Leu Ile Pro Val Asp Ser Leu Arg Asn Ser 
            20                  25                  30          


Thr Ser Phe Arg Pro Tyr Cys Leu Leu Asn Arg Lys Phe Ser Ser Ser 
        35                  40                  45              


Arg Phe Trp Lys Pro Arg Tyr Ser Cys Val Asn Leu Ser Ile Lys Asp 
    50                  55                  60                  


Ile Leu Glu Pro Ser Ala Pro Glu Pro Glu Pro Glu Cys Phe Gly Ser 
65                  70                  75                  80  


Phe Lys Val Ser Asp Val Val Asp Gly Asn Ile Gln Gly Arg Val Met 
                85                  90                  95      


Leu Ser Gly Met Gly Glu Gly Lys Ile Ser Gly Gly Ala Ala Val Ser 
            100                 105                 110         


Asp Ser Ser Ser Ala Ser Met Asn Val Cys Ile Leu Arg Val Thr Gln 
        115                 120                 125             


Lys Thr Trp Glu Thr Met Gln His Glu Arg His Leu Gln Gln Pro Glu 
    130                 135                 140                 


Asn Lys Ile Leu Gln Gln Leu Arg Ser Arg Gly Asp Asp Leu Phe Val 
145                 150                 155                 160 


Val Thr Glu Val Leu Gln Thr Lys Glu Glu Val Gln Ile Thr Glu Val 
                165                 170                 175     


His Ser Gln Glu Gly Ser Gly Gln Phe Thr Leu Pro Gly Ala Leu Cys 
            180                 185                 190         


Leu Lys Gly Glu Gly Lys Gly His Gln Ser Arg Lys Lys Met Val Thr 
        195                 200                 205             


Ile Pro Ala Gly Ser Ile Leu Ala Phe Arg Val Ala Gln Leu Leu Ile 
    210                 215                 220                 


Gly Ser Lys Trp Asp Ile Leu Leu Val Ser Asp Glu Lys Gln Arg Thr 
225                 230                 235                 240 


Phe Glu Pro Ser Ser Gly Asp Arg Lys Ala Val Gly Gln Arg His His 
                245                 250                 255     


Gly Leu Asn Val Leu Ala Ala Leu Cys Ser Ile Gly Lys Gln Leu Ser 
            260                 265                 270         


Leu Leu Ser Asp Gly Ile Asp Glu Glu Glu Leu Ile Glu Ala Ala Asp 
        275                 280                 285             


Phe Gln Gly Leu Tyr Ala Glu Val Lys Ala Cys Ser Ser Glu Leu Glu 
    290                 295                 300                 


Ser Leu Glu Met Glu Leu Arg Gln Gln Ile Leu Val Asn Ile Gly Lys 
305                 310                 315                 320 


Ile Leu Gln Asp Gln Pro Ser Met Glu Ala Leu Glu Ala Ser Leu Gly 
                325                 330                 335     


Gln Gly Leu Cys Ser Gly Gly Gln Val Glu Pro Leu Asp Gly Pro Ala 
            340                 345                 350         


Gly Cys Ile Leu Glu Cys Leu Val Leu Asp Ser Gly Glu Leu Val Pro 
        355                 360                 365             


Glu Leu Ala Ala Pro Ile Phe Tyr Leu Leu Gly Ala Leu Ala Val Leu 
    370                 375                 380                 


Ser Glu Thr Gln Gln Gln Leu Leu Ala Lys Ala Leu Glu Thr Thr Val 
385                 390                 395                 400 


Leu Ser Lys Gln Leu Glu Leu Val Lys His Val Leu Glu Gln Ser Thr 
                405                 410                 415     


Pro Trp Gln Glu Gln Ser Ser Val Ser Leu Pro Thr Val Leu Leu Gly 
            420                 425                 430         


Asp Cys Trp Asp Glu Lys Asn Pro Thr Trp Val Leu Leu Glu Glu Cys 
        435                 440                 445             


Gly Leu Arg Leu Gln Val Glu Ser Pro Gln Val His Trp Glu Pro Thr 
    450                 455                 460                 


Ser Leu Ile Pro Thr Ser Ala Leu Tyr Ala Ser Leu Phe Leu Leu Ser 
465                 470                 475                 480 


Ser Leu Gly Gln Lys Pro Cys 
                485         


<210>  11
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Arg Glu Val Asp Ala Asp 
1               5                   10                  15      


Gly Asp Leu Ile Ala Val Ser Asn Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Phe Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Leu Thr Leu Gly Asp Val Leu Ile Glu 
    50                  55                  60                  


Asp Gln Phe Pro Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Gly Lys Phe Ala Asn His Val Ser Gly Thr Leu Glu Thr Ala Leu 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Leu Gly Gly Ser Ser Arg Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Leu Gln Gln Leu 
        115                 120                 125             


Ile Arg Asp Ser Ala Glu Arg Thr Ile Asn Leu Arg Asn Pro Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Gly Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Thr Thr Met Gln Lys Cys Val Ile Ser Glu His Met Gln Val 
                165                 170                 175     


Glu Glu Lys Cys Gly Gly Ile Val Gly Ile Gln Thr Lys Thr Val Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Asn Val Thr Lys Asp Ser Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Val Ile Glu Leu 
    210                 215                 220                 


Tyr Val Lys Leu Asp Gly Gln Phe Glu Phe Cys Leu Leu Arg Gly Lys 
225                 230                 235                 240 


Gln Gly Gly Phe Glu Asn Lys Lys Arg Ile Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Val Phe Arg Glu Phe Ala Phe Ile Asp Met Pro Asp Ala Ala 
            260                 265                 270         


His Gly Ile Ser Ser Gln Asp Gly Pro Leu Ser Val Leu Lys Gln Ala 
        275                 280                 285             


Thr Leu Leu Leu Glu Arg Asn Phe His Pro Phe Ala Glu Leu Pro Glu 
    290                 295                 300                 


Pro Gln Gln Thr Ala Leu Ser Asp Ile Phe Gln Ala Val Leu Phe Asp 
305                 310                 315                 320 


Asp Glu Leu Leu Met Val Leu Glu Pro Val Cys Asp Asp Leu Val Ser 
                325                 330                 335     


Gly Leu Ser Pro Thr Val Ala Val Leu Gly Glu Leu Lys Pro Arg Gln 
            340                 345                 350         


Gln Gln Asp Leu Val Ala Phe Leu Gln Leu Val Gly Cys Ser Leu Gln 
        355                 360                 365             


Gly Gly Cys Pro Gly Pro Glu Asp Ala Gly Ser Lys Gln Leu Phe Met 
    370                 375                 380                 


Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Ser Ala 
385                 390                 395                 400 


Ala Ala Leu Leu Gly Thr Cys Cys Lys Leu Gln Ile Ile Pro Thr Leu 
                405                 410                 415     


Cys His Leu Leu Arg Ala Leu Ser Asp Asp Gly Val Ser Asp Leu Glu 
            420                 425                 430         


Asp Pro Thr Leu Thr Pro Leu Lys Asp Thr Glu Arg Phe Gly Ile Val 
        435                 440                 445             


Gln Arg Leu Phe Ala Ser Ala Asp Ile Ser Leu Glu Arg Leu Lys Ser 
    450                 455                 460                 


Ser Val Lys Ala Val Ile Leu Lys Asp Ser Lys Val Phe Pro Leu Leu 
465                 470                 475                 480 


Leu Cys Ile Thr Leu Asn Gly Leu Cys Ala Leu Gly Arg Glu His Ser 
                485                 490                 495     


<210>  12
<211>  512
<212>  PRT
<213>  Mus musculus

<400>  12

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Lys Glu Val Asp Ala Gly 
1               5                   10                  15      


Gly Asp Leu Ile Ser Val Ser His Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Tyr Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Ile Leu Ser Ala Thr Leu Glu Asp Val Leu Thr Glu 
    50                  55                  60                  


Gly His Cys Leu Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Ser Lys Cys Glu Asn His Lys Ser Gly Ala Ile Gly Thr Val Val 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Val Gly Gly Lys Gly Val Val Glu Ser His 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Val Gln Gln Leu 
        115                 120                 125             


Ile Gln Asp Ala Val Lys Arg Thr Val Asn Met Asp Asn Leu Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Ser Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Met Thr Thr Gln Lys Cys Val Ile Ser Glu His Val Gln Ser 
                165                 170                 175     


Glu Glu Thr Cys Gly Gly Met Val Gly Ile Gln Thr Lys Thr Ile Gln 
            180                 185                 190         


Val Ser Ala Thr Glu Asp Gly Thr Val Thr Thr Asp Thr Asn Val Val 
        195                 200                 205             


Leu Glu Ile Pro Ala Ala Thr Thr Ile Ala Tyr Gly Ile Met Glu Leu 
    210                 215                 220                 


Phe Val Lys Gln Asp Gly Gln Phe Glu Phe Cys Leu Leu Gln Gly Lys 
225                 230                 235                 240 


His Gly Gly Phe Glu His Glu Arg Lys Leu Asp Ser Val Tyr Leu Asp 
                245                 250                 255     


Pro Leu Ala Tyr Arg Glu Phe Ala Phe Leu Asp Met Leu Asp Gly Gly 
            260                 265                 270         


Gln Gly Ile Ser Ser Gln Asp Gly Pro Leu Arg Val Val Lys Gln Ala 
        275                 280                 285             


Thr Leu His Leu Glu Arg Ser Phe His Pro Phe Ala Val Leu Pro Ala 
    290                 295                 300                 


Gln Gln Gln Arg Ala Leu Phe Cys Val Leu Gln Lys Ile Leu Phe Asp 
305                 310                 315                 320 


Glu Glu Leu Leu Arg Ala Leu Glu Gln Val Cys Asp Asp Val Ala Gly 
                325                 330                 335     


Gly Leu Trp Ser Ser Gln Ala Val Leu Ala Met Glu Glu Leu Thr Asp 
            340                 345                 350         


Ser Gln Gln Gln Asp Leu Thr Ala Phe Leu Gln Leu Val Gly Tyr Arg 
        355                 360                 365             


Ile Gln Gly Glu His Pro Gly Pro Gln Asp Glu Val Ser Asn Gln Lys 
    370                 375                 380                 


Leu Phe Ala Thr Ala Tyr Phe Leu Val Ser Ala Leu Ala Glu Met Pro 
385                 390                 395                 400 


Asp Asn Ala Thr Val Phe Leu Gly Thr Cys Cys Lys Leu His Val Ile 
                405                 410                 415     


Ser Ser Leu Cys Cys Leu Leu His Ala Leu Ser Asp Asp Ser Val Cys 
            420                 425                 430         


Asp Phe His Asn Pro Thr Leu Ala Pro Leu Arg Asp Thr Glu Arg Phe 
        435                 440                 445             


Gly Ile Val Gln Arg Leu Phe Ala Ser Ala Asp Ile Ala Leu Glu Arg 
    450                 455                 460                 


Met Gln Phe Ser Ala Lys Ala Thr Ile Leu Lys Asp Ser Cys Ile Phe 
465                 470                 475                 480 


Pro Leu Ile Leu His Ile Thr Leu Ser Gly Leu Ser Thr Leu Ser Lys 
                485                 490                 495     


Glu His Glu Glu Glu Leu Cys Gln Ser Gly His Ala Thr Gly Gln Asp 
            500                 505                 510         


<210>  13
<211>  507
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Phe Ala Lys Ala Thr Arg Asn Phe Leu Lys Glu Val Asp Ala Gly 
1               5                   10                  15      


Gly Asp Leu Ile Ser Val Ser His Leu Asn Asp Ser Asp Lys Leu Gln 
            20                  25                  30          


Leu Leu Ser Leu Val Thr Lys Lys Lys Arg Tyr Trp Cys Trp Gln Arg 
        35                  40                  45              


Pro Lys Tyr Gln Phe Leu Ser Ala Thr Leu Gly Asp Val Leu Thr Glu 
    50                  55                  60                  


Gly His Cys Leu Ser Pro Val Val Val Glu Ser Asp Phe Val Lys Tyr 
65                  70                  75                  80  


Glu Ser Lys Cys Glu Asn His Lys Ser Gly Thr Ile Gly Thr Val Met 
                85                  90                  95      


Gly Lys Val Lys Leu Asn Val Gly Gly Lys Gly Leu Val Glu Ser Gln 
            100                 105                 110         


Ser Ser Phe Gly Thr Leu Arg Lys Gln Glu Val Asp Val Gln Gln Leu 
        115                 120                 125             


Ile Gln Asp Ala Val Gly Arg Thr Val Asn Leu Asp Ser Leu Val Leu 
    130                 135                 140                 


Gln Gln Val Leu Glu Ser Arg Asn Glu Val Leu Cys Val Leu Thr Gln 
145                 150                 155                 160 


Lys Ile Val Thr Thr Gln Lys Cys Val Ile Ser Glu His Val Gln Ser 
                165                 170                 175     


Glu Glu Thr Cys Gly Gly Met Val Gly Ile Gln Thr Lys Ile Val Gln 
            180                 185                 190         


Val Pro His Leu Ser Met Glu Asp Val Ser His Gly Arg Leu Arg Arg 
        195                 200                 205             


Ala Val Phe Gly Ser Gly Leu Arg Glu Ala Trp Arg Lys Ser Thr Val 
    210                 215                 220                 


Met Pro Glu Phe Cys Leu Leu Gln Gly Lys His Gly Gly Phe Glu Gln 
225                 230                 235                 240 


Glu Arg Lys Val Asp Ser Val Tyr Leu Asp Pro Leu Ala Tyr Arg Glu 
                245                 250                 255     


Phe Ala Phe Leu Asp Met Pro Asp Gly Gly Gln Gly Ile Ser Ser Gln 
            260                 265                 270         


Asp Gly Pro Leu Arg Val Leu Lys Gln Ala Thr Leu His Leu Glu Arg 
        275                 280                 285             


Ser Phe Arg Ser Phe Ala Val Leu Pro Ala Gln Gln Gln Met Ala Leu 
    290                 295                 300                 


Phe Cys Ile Leu Gln Lys Ile Leu Phe Asp Glu Glu Leu Leu Arg Ala 
305                 310                 315                 320 


Leu Glu Gln Val Cys Asp Asp Val Ala Gly Gly Leu Trp Ser Ser Gln 
                325                 330                 335     


Ala Ile Leu Ala Met Glu Glu Leu Thr Gly Ser Gln Gln Gln Asp Leu 
            340                 345                 350         


Thr Ala Phe Leu Lys Leu Val Gly Tyr Arg Val Gln Gly Glu His Pro 
        355                 360                 365             


Gly Pro Gln Asp Glu Val Ser Asn Gln Lys Leu Phe Ala Thr Ala Tyr 
    370                 375                 380                 


Phe Leu Val Ser Ala Leu Ala Glu Met Pro Asp Asn Ala Thr Val Phe 
385                 390                 395                 400 


Leu Gly Thr Cys Cys Lys Leu His Val Ile Pro Ser Leu Cys His Leu 
                405                 410                 415     


Leu His Ala Leu Ser Asp Asp Ser Val Cys Asp Phe Gln Asp Pro Thr 
            420                 425                 430         


Leu Ala Pro Leu Arg Asp Thr Glu Arg Phe Gly Ile Val Gln Arg Leu 
        435                 440                 445             


Phe Ala Ser Ala Asp Ile Ala Leu Glu Arg Met Gln Phe Ser Ala Lys 
    450                 455                 460                 


Ala Thr Ile Leu Lys Asp Ser Cys Met Phe Pro Leu Ile Leu His Ile 
465                 470                 475                 480 


Thr Leu Ser Gly Leu Tyr Thr Leu Ser Lys Glu His Glu Glu His Leu 
                485                 490                 495     


Phe Gln Ser Glu Val His Ala Thr Ser Gln Asp 
            500                 505         


<210>  14
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Phe Ala Ala Ala Thr Lys Ser Phe Val Lys Gln Val Gly Asp Gly 
1               5                   10                  15      


Gly Arg Leu Val Pro Val Pro Ser Leu Ser Glu Ala Asp Lys Tyr Gln 
            20                  25                  30          


Pro Leu Ser Leu Val Val Lys Lys Lys Arg Cys Phe Leu Phe Pro Arg 
        35                  40                  45              


Tyr Lys Phe Thr Ser Thr Pro Phe Thr Leu Lys Asp Ile Leu Leu Gly 
    50                  55                  60                  


Asp Arg Glu Ile Ser Ala Gly Ile Ser Ser Tyr Gln Leu Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Glu Ser Asp Val Ser Leu Tyr Gly Arg Arg Gly Asn His Ile 
                85                  90                  95      


Val Asn Asp Val Gly Ile Asn Val Ala Gly Ser Asp Ser Ile Ala Val 
            100                 105                 110         


Lys Ala Ser Phe Gly Ile Val Thr Lys His Glu Val Glu Val Ser Thr 
        115                 120                 125             


Leu Leu Lys Glu Ile Thr Thr Arg Lys Ile Asn Phe Asp His Ser Leu 
    130                 135                 140                 


Ile Arg Gln Ser Arg Ser Ser Arg Lys Ala Val Leu Cys Val Val Met 
145                 150                 155                 160 


Glu Ser Ile Arg Thr Thr Arg Gln Cys Ser Leu Ser Val His Ala Gly 
                165                 170                 175     


Ile Arg Gly Glu Ala Met Arg Phe His Phe Met Asp Glu Gln Asn Pro 
            180                 185                 190         


Lys Gly Arg Asp Lys Ala Ile Val Phe Pro Ala His Thr Thr Ile Ala 
        195                 200                 205             


Phe Ser Val Phe Glu Leu Phe Ile Tyr Leu Asp Gly Ala Phe Asp Leu 
    210                 215                 220                 


Cys Val Thr Ser Val Ser Lys Gly Gly Phe Glu Arg Glu Glu Thr Ala 
225                 230                 235                 240 


Thr Phe Ala Leu Leu Tyr Arg Leu Arg Asn Ile Leu Phe Glu Arg Asn 
                245                 250                 255     


Arg Arg Val Met Asp Val Ile Ser Arg Ser Gln Leu Tyr Leu Asp Asp 
            260                 265                 270         


Leu Phe Ser Asp Tyr Tyr Asp Lys Pro Leu Ser Met Thr Asp Ile Ser 
        275                 280                 285             


Leu Lys Glu Gly Thr His Ile Arg Val Asn Leu Leu Asn His Asn Ile 
    290                 295                 300                 


Pro Lys Gly Pro Cys Ile Leu Cys Gly Met Gly Asn Phe Lys Arg Glu 
305                 310                 315                 320 


Thr Val Tyr Gly Cys Phe Gln Cys Ser Val Asp Gly Gln Lys Tyr Val 
                325                 330                 335     


Arg Leu His Ala Val Pro Cys Phe Asp Ile Trp His Lys Arg Met Lys 
            340                 345                 350         


<210>  15
<211>  352
<212>  PRT
<213>  Bos taurus

<400>  15

Met Phe Ala Ala Ala Thr Lys Ser Phe Val Lys Gln Val Gly Asp Gly 
1               5                   10                  15      


Gly Arg Leu Val Pro Val Pro Ser Leu Ser Glu Ala Asp Lys Tyr Gln 
            20                  25                  30          


Pro Leu Ser Leu Val Val Lys Lys Lys Arg Cys Phe Leu Phe Pro Arg 
        35                  40                  45              


Tyr Lys Phe Thr Ser Thr Pro Phe Thr Leu Lys Asp Ile Leu Leu Gly 
    50                  55                  60                  


Asn Arg Glu Ile Ser Ala Gly Ile Ser Ser Tyr Gln Leu Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Glu Ser Asp Val Ser Leu Tyr Gly Arg Arg Gly Asn His Ile 
                85                  90                  95      


Val Ser Asp Val Gly Ile Asn Val Thr Gly Ser Asp Ser Ile Ala Val 
            100                 105                 110         


Lys Ala Ser Phe Gly Val Val Thr Lys His Glu Val Glu Val Ser Thr 
        115                 120                 125             


Leu Leu Lys Glu Ile Thr Thr Arg Lys Ile Asn Phe Asp His Ser Leu 
    130                 135                 140                 


Ile Arg Gln Ser Arg Ser Ser Arg Lys Ala Val Leu Cys Val Val Met 
145                 150                 155                 160 


Glu Ser Ile Arg Thr Thr Arg Gln Cys Ser Leu Ser Val His Ala Gly 
                165                 170                 175     


Ile Arg Gly Glu Ala Met Arg Phe His Phe Met Asp Glu Gln Asn Pro 
            180                 185                 190         


Lys Gly Arg Asp Lys Ala Ile Val Phe Pro Ala His Thr Thr Ile Ala 
        195                 200                 205             


Phe Ser Val Phe Glu Leu Phe Ile Tyr Leu Asp Gly Ala Phe Asp Leu 
    210                 215                 220                 


Cys Val Thr Ser Val Ser Lys Gly Gly Phe Glu Arg Glu Glu Thr Ala 
225                 230                 235                 240 


Thr Phe Ala Leu Leu Tyr Arg Leu Arg Asn Ile Leu Phe Glu Arg Asn 
                245                 250                 255     


Arg Arg Val Met Asp Ala Ile Ser Arg Ser Gln Leu Tyr Leu Asp Asp 
            260                 265                 270         


Leu Phe Ser Asp Tyr Tyr Asp Lys Pro Leu Ser Met Ser Asp Ile Ser 
        275                 280                 285             


Leu Lys Glu Gly Thr His Ile Arg Val Asn Leu Leu Asn His Asn Ile 
    290                 295                 300                 


Pro Lys Gly Pro Cys Ile Leu Cys Gly Met Gly Asn Phe Lys Arg Glu 
305                 310                 315                 320 


Thr Val Tyr Gly Cys Phe Gln Cys Ser Val Asp Gly Gln Lys Tyr Val 
                325                 330                 335     


Arg Leu His Ala Val Pro Cys Phe Asp Ile Trp His Lys Arg Met Lys 
            340                 345                 350         


<210>  16
<211>  352
<212>  PRT
<213>  Mus musculus

<400>  16

Met Phe Ala Ala Ala Thr Lys Ser Phe Val Lys Gln Val Gly Asp Gly 
1               5                   10                  15      


Gly Arg Leu Val Pro Val Pro Ser Leu Ser Glu Ala Asp Lys Tyr Gln 
            20                  25                  30          


Pro Leu Ser Leu Val Val Lys Lys Lys Arg Cys Phe Leu Phe Pro Arg 
        35                  40                  45              


Cys Lys Phe Thr Ser Thr Pro Phe Thr Leu Lys Asp Ile Leu Leu Gly 
    50                  55                  60                  


Asp Arg Glu Ile Ser Ala Gly Ile Ser Ser Tyr Gln Leu Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Glu Ser Asp Val Ser Leu Tyr Gly Arg Arg Ser Asn His Ile 
                85                  90                  95      


Val Asn Asp Val Gly Ile Asn Val Thr Gly Ser Asp Ser Ile Ala Val 
            100                 105                 110         


Lys Ala Ser Phe Gly Val Val Thr Lys His Glu Val Glu Val Ser Thr 
        115                 120                 125             


Leu Leu Lys Glu Ile Thr Ala Arg Lys Ile Asn Phe Asp His Ser Leu 
    130                 135                 140                 


Ile Arg Gln Ser Arg Ser Ser Arg Lys Ala Val Leu Cys Val Val Met 
145                 150                 155                 160 


Glu Ser Ile Arg Thr Thr Arg Gln Cys Ser Leu Ser Val His Ala Gly 
                165                 170                 175     


Ile Arg Gly Glu Ala Met Arg Phe His Phe Met Asp Glu Gln Asn Pro 
            180                 185                 190         


Lys Gly Arg Glu Lys Ala Ile Val Phe Pro Ala His Thr Thr Ile Ala 
        195                 200                 205             


Phe Ser Val Phe Glu Leu Phe Ile Tyr Leu Asp Gly Ala Phe Asp Ile 
    210                 215                 220                 


Cys Val Thr Ser Val Ser Lys Gly Gly Phe Glu Arg Glu Glu Thr Thr 
225                 230                 235                 240 


Thr Phe Ala Met Phe Tyr Arg Leu Arg Asn Ile Leu Phe Glu Arg Asn 
                245                 250                 255     


Arg Arg Val Met Asp Ala Ile Ser Arg Ser Gln Leu Tyr Leu Asp Asp 
            260                 265                 270         


Leu Phe Ser Asp Phe Tyr Asp Lys Pro Leu Ser Met Thr Asp Ile Ser 
        275                 280                 285             


Leu Lys Glu Gly Thr His Ile Arg Val Asn Leu Leu Asn His Asn Ile 
    290                 295                 300                 


Pro Lys Gly Pro Cys Ile Leu Cys Gly Met Gly Asn Leu Lys Arg Glu 
305                 310                 315                 320 


Thr Val Tyr Gly Cys Phe Gln Cys Ser Val Asp Gly Val Lys Tyr Val 
                325                 330                 335     


Arg Leu His Ala Val Pro Cys Phe Asp Ile Trp His Lys Arg Met Lys 
            340                 345                 350         


<210>  17
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Thr Phe Pro Pro Gly Glu 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Val Leu Asn Ser Leu Ala 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Glu Leu Asp Ser Gly Leu 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20

Ser Ser Asn Asp Met Lys Leu 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Phe Leu Thr Asp Gly Val Pro 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Met Pro Asp Ala Ala His 
1               5           


<210>  23
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser 
1               5                   10                  15      


Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr 
            20                  25                  30          


Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile His Phe 
        35                  40                  45              


Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr 
    50                  55                  60                  


Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp Gly Val 
65                  70                  75                  80  


Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Gly His 
                85                  90                  95      


Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys Pro Val 
            100                 105                 110         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser 
        115                 120                 125             


His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala 
    130                 135                 140                 


Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro 
                165                 170                 175     


Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala 
            180                 185                 190         


Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln 
        195                 200                 205             


Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr 
    210                 215                 220                 


Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys 
225                 230                 235                 240 


Tyr Pro Arg 
            


<210>  24
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser Trp 
1               5                   10                  15      


Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr Asn 
            20                  25                  30          


Asp Ile Thr Met Glu Glu Asp Ser Phe Ile Asn Lys Ile His Phe Lys 
        35                  40                  45              


Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr Val 
    50                  55                  60                  


Gly Trp Glu Val Ser Thr Glu Lys Met Tyr Val Arg Asp Gly Val Leu 
65                  70                  75                  80  


Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Ser His Tyr 
                85                  90                  95      


Arg Cys Asp Phe Arg Thr Thr Tyr Lys Val Lys Gln Lys Ala Val Lys 
            100                 105                 110         


Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser His 
        115                 120                 125             


Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala Arg 
    130                 135                 140                 


Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Met Val Ser Lys Gly Glu Glu Thr Ile Met Ser Val Ile Lys Pro Asp 
                165                 170                 175     


Met Lys Ile Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe 
            180                 185                 190         


Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr 
        195                 200                 205             


Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp 
    210                 215                 220                 


Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr 
225                 230                 235                 240 


Pro Arg 
        


<210>  25
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser Trp 
1               5                   10                  15      


Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr Asn 
            20                  25                  30          


Asp Ile Thr Met Glu Glu Asp Ser Phe Ile Asn Lys Ile His Phe Lys 
        35                  40                  45              


Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr Val 
    50                  55                  60                  


Gly Trp Glu Val Ser Thr Glu Lys Met Tyr Val Arg Asp Gly Val Leu 
65                  70                  75                  80  


Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Ser His Tyr 
                85                  90                  95      


Arg Cys Asp Phe Arg Thr Thr Tyr Lys Val Lys Gln Lys Ala Val Lys 
            100                 105                 110         


Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser His 
        115                 120                 125             


Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala Arg 
    130                 135                 140                 


Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro Asp 
                165                 170                 175     


Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe 
            180                 185                 190         


Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr 
        195                 200                 205             


Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp 
    210                 215                 220                 


Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr 
225                 230                 235                 240 


Pro Arg 
        


<210>  26
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser Trp 
1               5                   10                  15      


Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr Asn 
            20                  25                  30          


Asp Ile Thr Met Glu Glu Asp Ser Phe Ile Asn Lys Ile His Phe Lys 
        35                  40                  45              


Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr Val 
    50                  55                  60                  


Gly Trp Glu Val Ser Thr Glu Lys Met Tyr Val Arg Asp Gly Val Leu 
65                  70                  75                  80  


Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Ser His Tyr 
                85                  90                  95      


Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys Ala Val Lys 
            100                 105                 110         


Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser His 
        115                 120                 125             


Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala Arg 
    130                 135                 140                 


Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro Asp 
                165                 170                 175     


Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe 
            180                 185                 190         


Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr 
        195                 200                 205             


Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp 
    210                 215                 220                 


Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr 
225                 230                 235                 240 


Pro Arg 
        


<210>  27
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser Trp 
1               5                   10                  15      


Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr Asn 
            20                  25                  30          


Asp Ile Thr Met Glu Glu Asp Ser Phe Ile Asn Lys Ile His Phe Lys 
        35                  40                  45              


Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr Val 
    50                  55                  60                  


Gly Trp Glu Val Ser Thr Glu Lys Met Tyr Val Arg Asp Gly Val Leu 
65                  70                  75                  80  


Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Gly His Tyr 
                85                  90                  95      


Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys Ala Val Lys 
            100                 105                 110         


Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser His 
        115                 120                 125             


Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala Arg 
    130                 135                 140                 


Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro Asp 
                165                 170                 175     


Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe 
            180                 185                 190         


Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr 
        195                 200                 205             


Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp 
    210                 215                 220                 


Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr 
225                 230                 235                 240 


Pro Arg 
        


<210>  28
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser Trp 
1               5                   10                  15      


Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr Asn 
            20                  25                  30          


Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile His Phe Lys 
        35                  40                  45              


Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr Val 
    50                  55                  60                  


Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Val Arg Asp Gly Val Leu 
65                  70                  75                  80  


Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Gly His Tyr 
                85                  90                  95      


Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys Ala Val Lys 
            100                 105                 110         


Leu Pro Asp Ser His Phe Val Asp His Arg Ile Glu Ile Leu Ser His 
        115                 120                 125             


Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala Arg 
    130                 135                 140                 


Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro Asp 
                165                 170                 175     


Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe 
            180                 185                 190         


Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr 
        195                 200                 205             


Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp 
    210                 215                 220                 


Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr 
225                 230                 235                 240 


Pro Arg 
        


<210>  29
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser Trp 
1               5                   10                  15      


Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr Asn 
            20                  25                  30          


Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile His Phe Lys 
        35                  40                  45              


Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr Val 
    50                  55                  60                  


Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp Gly Val Leu 
65                  70                  75                  80  


Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Gly His Tyr 
                85                  90                  95      


Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys Ala Val Lys 
            100                 105                 110         


Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser His 
        115                 120                 125             


Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala Arg 
    130                 135                 140                 


Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro Asp 
                165                 170                 175     


Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe 
            180                 185                 190         


Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr 
        195                 200                 205             


Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp 
    210                 215                 220                 


Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr 
225                 230                 235                 240 


Pro Arg 
        


<210>  30
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser Trp 
1               5                   10                  15      


Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr Asn 
            20                  25                  30          


Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile His Phe Lys 
        35                  40                  45              


Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr Val 
    50                  55                  60                  


Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp Gly Val Leu 
65                  70                  75                  80  


Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Gly His Tyr 
                85                  90                  95      


Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys Pro Val Lys 
            100                 105                 110         


Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser His 
        115                 120                 125             


Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala Arg 
    130                 135                 140                 


Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro Asp 
                165                 170                 175     


Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe 
            180                 185                 190         


Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr 
        195                 200                 205             


Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp 
    210                 215                 220                 


Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr 
225                 230                 235                 240 


Pro Arg 
        


<210>  31
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile Lys Pro Asp Met 
1               5                   10                  15      


Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly His Ala Phe Val 
            20                  25                  30          


Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly Ile Gln Thr Ile 
        35                  40                  45              


Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe Ala Tyr Asp Ile 
    50                  55                  60                  


Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe Thr Lys Tyr Pro 
65                  70                  75                  80  


Arg Ser Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Tyr Ser 
                85                  90                  95      


Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile Ala Thr 
            100                 105                 110         


Asn Asp Ile Thr Met Glu Glu Asp Ser Phe Ile Asn Lys Ile His Phe 
        115                 120                 125             


Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys Arg Thr 
    130                 135                 140                 


Val Gly Trp Glu Val Ser Thr Glu Lys Met Tyr Val Arg Asp Gly Val 
145                 150                 155                 160 


Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly Ser His 
                165                 170                 175     


Tyr Arg Cys Asp Phe Arg Thr Thr Tyr Lys Val Lys Gln Lys Ala Val 
            180                 185                 190         


Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile Leu Ser 
        195                 200                 205             


His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala Val Ala 
    210                 215                 220                 


Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Gly Gly Gly Ser 
1               


<210>  33
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly 
        275                 280                 285             


Tyr Ser Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile 
    290                 295                 300                 


Ala Thr Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile 
305                 310                 315                 320 


His Phe Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys 
                325                 330                 335     


Arg Thr Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp 
            340                 345                 350         


Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly 
        355                 360                 365             


Gly His Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys 
    370                 375                 380                 


Pro Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
385                 390                 395                 400 


Leu Ser His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala 
                405                 410                 415     


Val Ala Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly 
            420                 425                 430         


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile 
        435                 440                 445             


Lys Pro Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly 
    450                 455                 460                 


His Ala Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly 
465                 470                 475                 480 


Ile Gln Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe 
                485                 490                 495     


Ala Tyr Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe 
            500                 505                 510         


Thr Lys Tyr Pro Arg Gly Gly Gly Val Pro Ala Glu Gly Ala Phe Thr 
        515                 520                 525             


Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu 
545                 550                 555                 560 


Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala 
                565                 570                 575     


Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro 
            580                 585                 590         


Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val 
        595                 600                 605             


Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met 
    610                 615                 620                 


Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln 
625                 630                 635                 640 


Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser 
                645                 650                 655     


Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu 
            660                 665                 670         


Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu 
        675                 680                 685             


Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro 
    690                 695                 700                 


Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu 
705                 710                 715                 720 


Ser Gly Leu Ser Gln Glu Pro His 
                725             


<210>  34
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Gln Pro Gln Tyr Gln Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly 
        275                 280                 285             


Tyr Ser Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile 
    290                 295                 300                 


Ala Thr Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile 
305                 310                 315                 320 


His Phe Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys 
                325                 330                 335     


Arg Thr Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp 
            340                 345                 350         


Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly 
        355                 360                 365             


Gly His Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys 
    370                 375                 380                 


Pro Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
385                 390                 395                 400 


Leu Ser His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala 
                405                 410                 415     


Val Ala Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly 
            420                 425                 430         


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile 
        435                 440                 445             


Lys Pro Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly 
    450                 455                 460                 


His Ala Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly 
465                 470                 475                 480 


Ile Gln Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe 
                485                 490                 495     


Ala Tyr Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe 
            500                 505                 510         


Thr Lys Tyr Pro Arg Gly Gly Gly Val Pro Ala Glu Gly Ala Phe Thr 
        515                 520                 525             


Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu 
545                 550                 555                 560 


Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala 
                565                 570                 575     


Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro 
            580                 585                 590         


Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val 
        595                 600                 605             


Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met 
    610                 615                 620                 


Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln 
625                 630                 635                 640 


Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser 
                645                 650                 655     


Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu 
            660                 665                 670         


Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu 
        675                 680                 685             


Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro 
    690                 695                 700                 


Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu 
705                 710                 715                 720 


Ser Gly Leu Ser Gln Glu Pro His 
                725             


<210>  35
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Glu Pro Glu Tyr Glu Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly 
        275                 280                 285             


Tyr Ser Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile 
    290                 295                 300                 


Ala Thr Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile 
305                 310                 315                 320 


His Phe Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys 
                325                 330                 335     


Arg Thr Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp 
            340                 345                 350         


Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly 
        355                 360                 365             


Gly His Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys 
    370                 375                 380                 


Pro Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
385                 390                 395                 400 


Leu Ser His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala 
                405                 410                 415     


Val Ala Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly 
            420                 425                 430         


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile 
        435                 440                 445             


Lys Pro Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly 
    450                 455                 460                 


His Ala Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly 
465                 470                 475                 480 


Ile Gln Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe 
                485                 490                 495     


Ala Tyr Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe 
            500                 505                 510         


Thr Lys Tyr Pro Arg Gly Gly Gly Val Pro Ala Glu Gly Ala Phe Thr 
        515                 520                 525             


Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu 
545                 550                 555                 560 


Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala 
                565                 570                 575     


Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro 
            580                 585                 590         


Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val 
        595                 600                 605             


Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met 
    610                 615                 620                 


Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln 
625                 630                 635                 640 


Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser 
                645                 650                 655     


Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu 
            660                 665                 670         


Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu 
        675                 680                 685             


Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro 
    690                 695                 700                 


Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu 
705                 710                 715                 720 


Ser Gly Leu Ser Gln Glu Pro His 
                725             


<210>  36
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Gln Gln Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly 
        275                 280                 285             


Tyr Ser Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile 
    290                 295                 300                 


Ala Thr Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile 
305                 310                 315                 320 


His Phe Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys 
                325                 330                 335     


Arg Thr Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp 
            340                 345                 350         


Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly 
        355                 360                 365             


Gly His Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys 
    370                 375                 380                 


Pro Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
385                 390                 395                 400 


Leu Ser His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala 
                405                 410                 415     


Val Ala Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly 
            420                 425                 430         


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile 
        435                 440                 445             


Lys Pro Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly 
    450                 455                 460                 


His Ala Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly 
465                 470                 475                 480 


Ile Gln Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe 
                485                 490                 495     


Ala Tyr Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe 
            500                 505                 510         


Thr Lys Tyr Pro Arg Gly Gly Gly Val Pro Ala Glu Gly Ala Phe Thr 
        515                 520                 525             


Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu 
545                 550                 555                 560 


Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala 
                565                 570                 575     


Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro 
            580                 585                 590         


Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val 
        595                 600                 605             


Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met 
    610                 615                 620                 


Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln 
625                 630                 635                 640 


Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser 
                645                 650                 655     


Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu 
            660                 665                 670         


Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu 
        675                 680                 685             


Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro 
    690                 695                 700                 


Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu 
705                 710                 715                 720 


Ser Gly Leu Ser Gln Glu Pro His 
                725             


<210>  37
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Glu Glu Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly 
        275                 280                 285             


Tyr Ser Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile 
    290                 295                 300                 


Ala Thr Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile 
305                 310                 315                 320 


His Phe Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys 
                325                 330                 335     


Arg Thr Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp 
            340                 345                 350         


Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly 
        355                 360                 365             


Gly His Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys 
    370                 375                 380                 


Pro Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
385                 390                 395                 400 


Leu Ser His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala 
                405                 410                 415     


Val Ala Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly 
            420                 425                 430         


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile 
        435                 440                 445             


Lys Pro Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly 
    450                 455                 460                 


His Ala Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly 
465                 470                 475                 480 


Ile Gln Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe 
                485                 490                 495     


Ala Tyr Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe 
            500                 505                 510         


Thr Lys Tyr Pro Arg Gly Gly Gly Val Pro Ala Glu Gly Ala Phe Thr 
        515                 520                 525             


Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu 
545                 550                 555                 560 


Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala 
                565                 570                 575     


Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro 
            580                 585                 590         


Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val 
        595                 600                 605             


Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met 
    610                 615                 620                 


Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln 
625                 630                 635                 640 


Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser 
                645                 650                 655     


Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu 
            660                 665                 670         


Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu 
        675                 680                 685             


Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro 
    690                 695                 700                 


Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu 
705                 710                 715                 720 


Ser Gly Leu Ser Gln Glu Pro His 
                725             


<210>  38
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Gln Gln Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Gln Pro Gln Tyr Gln Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly 
        275                 280                 285             


Tyr Ser Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile 
    290                 295                 300                 


Ala Thr Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile 
305                 310                 315                 320 


His Phe Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys 
                325                 330                 335     


Arg Thr Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp 
            340                 345                 350         


Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly 
        355                 360                 365             


Gly His Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys 
    370                 375                 380                 


Pro Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
385                 390                 395                 400 


Leu Ser His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala 
                405                 410                 415     


Val Ala Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly 
            420                 425                 430         


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile 
        435                 440                 445             


Lys Pro Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly 
    450                 455                 460                 


His Ala Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly 
465                 470                 475                 480 


Ile Gln Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe 
                485                 490                 495     


Ala Tyr Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe 
            500                 505                 510         


Thr Lys Tyr Pro Arg Gly Gly Gly Val Pro Ala Glu Gly Ala Phe Thr 
        515                 520                 525             


Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu 
545                 550                 555                 560 


Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala 
                565                 570                 575     


Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro 
            580                 585                 590         


Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val 
        595                 600                 605             


Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met 
    610                 615                 620                 


Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln 
625                 630                 635                 640 


Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser 
                645                 650                 655     


Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu 
            660                 665                 670         


Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu 
        675                 680                 685             


Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro 
    690                 695                 700                 


Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu 
705                 710                 715                 720 


Ser Gly Leu Ser Gln Glu Pro His 
                725             


<210>  39
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Glu Glu Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Glu Pro Glu Tyr Glu Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Ser Val Ile Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly 
        275                 280                 285             


Tyr Ser Trp Glu Arg Ser Met Thr Tyr Glu Asp Gly Gly Ile Cys Ile 
    290                 295                 300                 


Ala Thr Asn Asp Ile Thr Met Glu Gly Asp Ser Phe Ile Asn Lys Ile 
305                 310                 315                 320 


His Phe Lys Gly Thr Asn Phe Pro Pro Asn Gly Pro Val Met Gln Lys 
                325                 330                 335     


Arg Thr Val Gly Trp Glu Ala Ser Thr Glu Lys Met Tyr Glu Arg Asp 
            340                 345                 350         


Gly Val Leu Lys Gly Asp Val Lys Met Lys Leu Leu Leu Lys Gly Gly 
        355                 360                 365             


Gly His Tyr Arg Cys Asp Tyr Arg Thr Thr Tyr Lys Val Lys Gln Lys 
    370                 375                 380                 


Pro Val Lys Leu Pro Asp Tyr His Phe Val Asp His Arg Ile Glu Ile 
385                 390                 395                 400 


Leu Ser His Asp Lys Asp Tyr Asn Lys Val Lys Leu Tyr Glu His Ala 
                405                 410                 415     


Val Ala Arg Asn Ser Thr Asp Ser Met Asp Glu Leu Tyr Lys Gly Gly 
            420                 425                 430         


Ser Gly Gly Met Val Ser Lys Gly Glu Glu Thr Ile Thr Ser Val Ile 
        435                 440                 445             


Lys Pro Asp Met Lys Asn Lys Leu Arg Met Glu Gly Asn Val Asn Gly 
    450                 455                 460                 


His Ala Phe Val Ile Glu Gly Glu Gly Ser Gly Lys Pro Phe Glu Gly 
465                 470                 475                 480 


Ile Gln Thr Ile Asp Leu Glu Val Lys Glu Gly Ala Pro Leu Pro Phe 
                485                 490                 495     


Ala Tyr Asp Ile Leu Thr Thr Ala Phe His Tyr Gly Asn Arg Val Phe 
            500                 505                 510         


Thr Lys Tyr Pro Arg Gly Gly Gly Val Pro Ala Glu Gly Ala Phe Thr 
        515                 520                 525             


Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu 
    530                 535                 540                 


Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu 
545                 550                 555                 560 


Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala 
                565                 570                 575     


Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro 
            580                 585                 590         


Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val 
        595                 600                 605             


Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met 
    610                 615                 620                 


Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln 
625                 630                 635                 640 


Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser 
                645                 650                 655     


Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu 
            660                 665                 670         


Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu 
        675                 680                 685             


Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro 
    690                 695                 700                 


Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu 
705                 710                 715                 720 


Ser Gly Leu Ser Gln Glu Pro His 
                725             


<210>  40
<211>  634
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Gly 
            260                 265                 270         


Gly Gly Gly Met Leu Ala Thr Thr Leu Glu Arg Ile Glu Lys Asn Phe 
        275                 280                 285             


Val Ile Thr Asp Pro Arg Leu Pro Asp Asn Pro Ile Ile Phe Ala Ser 
    290                 295                 300                 


Asp Ser Phe Leu Gln Leu Thr Glu Tyr Ser Arg Glu Glu Ile Leu Gly 
305                 310                 315                 320 


Arg Asn Cys Arg Phe Leu Gln Gly Pro Glu Thr Asp Arg Ala Thr Val 
                325                 330                 335     


Arg Lys Ile Arg Asp Ala Ile Asp Asn Gln Thr Glu Val Thr Val Gln 
            340                 345                 350         


Leu Ile Asn Tyr Thr Lys Ser Gly Lys Lys Phe Trp Asn Val Phe His 
        355                 360                 365             


Leu Gln Pro Met Arg Asp Tyr Lys Gly Asp Val Gln Tyr Phe Ile Gly 
    370                 375                 380                 


Val Gln Leu Asp Gly Thr Glu Arg Leu His Gly Ala Ala Glu Arg Glu 
385                 390                 395                 400 


Ala Val Cys Leu Ile Lys Lys Thr Ala Phe Gln Ile Ala Glu Ala Ala 
                405                 410                 415     


Asn Asp Glu Asn Tyr Phe Gly Gly Gly Gly Val Pro Ala Glu Gly Ala 
            420                 425                 430         


Phe Thr Glu Asp Phe Gln Gly Leu Arg Ala Glu Val Glu Thr Ile Ser 
        435                 440                 445             


Lys Glu Leu Glu Leu Leu Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu 
    450                 455                 460                 


Gly Leu Glu Gly Val Leu Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu 
465                 470                 475                 480 


Glu Ala Leu Glu Gln Gly Gln Ser Leu Gly Pro Val Glu Pro Leu Asp 
                485                 490                 495     


Gly Pro Ala Gly Ala Val Leu Glu Cys Leu Val Leu Ser Ser Gly Met 
            500                 505                 510         


Leu Val Pro Glu Leu Ala Ile Pro Val Val Tyr Leu Leu Gly Ala Leu 
        515                 520                 525             


Thr Met Leu Ser Glu Thr Gln His Lys Leu Leu Ala Glu Ala Leu Glu 
    530                 535                 540                 


Ser Gln Thr Leu Leu Gly Pro Leu Glu Leu Val Gly Ser Leu Leu Glu 
545                 550                 555                 560 


Gln Ser Ala Pro Trp Gln Glu Arg Ser Thr Met Ser Leu Pro Pro Gly 
                565                 570                 575     


Leu Leu Gly Asn Ser Trp Gly Glu Gly Ala Pro Ala Trp Val Leu Leu 
            580                 585                 590         


Asp Glu Cys Gly Leu Glu Leu Gly Glu Asp Thr Pro His Val Cys Trp 
        595                 600                 605             


Glu Pro Gln Ala Gln Gly Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala 
    610                 615                 620                 


Leu Leu Ser Gly Leu Ser Gln Glu Pro His 
625                 630                 


