SEQUENCE LISTING

<110>   MedImmune Limited

<120>   METHODS FOR TREATING ATOPIC DERMATITIS AND RELATED DISORDERS

<130>   008264087

<150>   GB 2108379.5
<151>   2021-06-11

<160>   12

<170>   SeqWin2010, version 1.0

<210>   1
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   HCDR1

<400>   1
Asn Tyr Gly Leu Ser 
1               5   

<210>   2
<211>   17
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   HCDR2

<400>   2
Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe Gln 
1               5                   10                  15      

Gly 
    

<210>   3
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   HCDR3

<400>   3
Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu 
1               5                   10              

<210>   4
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   LCDR1

<400>   4
Gly Gly Asn Ile Ile Gly Ser Lys Leu Val His 
1               5                   10      

<210>   5
<211>   7
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   LCDR2

<400>   5
Asp Asp Gly Asp Arg Pro Ser 
1               5           

<210>   6
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   LCDR3

<400>   6
Gln Val Trp Asp Thr Gly Ser Asp Pro Val Val 
1               5                   10      

<210>   7
<211>   366
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   cDNA heavy chain variable domain

<400>   7
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc  60
tcctgcaagg cttctggtta cacctttaca aattatggtc tcagctgggt gcgacaggcc  120
cctggacaag ggcttgagtg gatgggatgg atcagcgcta ataatggcga cacaaattat  180
ggacaggaat tccagggcag agtcaccatg accacagata catccacgag cacagcctac  240
atggagttga ggagcctgag atctgacgac acggccgttt attactgtgc gagagactcc  300
agcagcagct gggcccgctg gtttttcgat ctctggggcc gggggacact ggtcaccgtc  360
tcctca                                                             366

<210>   8
<211>   122
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Polypeptide sequence heavy chain variable region

<400>   8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          

Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         

Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>   9
<211>   327
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   cDNA light chain variable domain

<400>   9
tcctatgtgc tgactcagcc accctcggtg tcagtggccc caggaaagac ggccaggatt  60
acctgtgggg gaaacatcat tggaagtaaa cttgtacact ggtaccagca gaagccaggc  120
caggcccctg tgctggtcat ctatgatgat ggcgaccggc cctcagggat ccctgagcga  180
ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaggccggg  240
gatgaggccg actattattg tcaggtgtgg gatactggta gtgatcccgt ggtattcggc  300
ggagggacca agctgaccgt cctaggt                                      327

<210>   10
<211>   108
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Polypeptide sequence light chain variable region

<400>   10
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      

Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             

<210>   11
<211>   449
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Heavy chain

<400>   11
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          

Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile Ser Ala Asn Asn Gly Asp Thr Asn Tyr Gly Gln Glu Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Ser Ser Ser Ser Trp Ala Arg Trp Phe Phe Asp Leu Trp 
            100                 105                 110         

Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             

Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 

Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 

Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     

Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         

Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 

Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         

Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             

Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         

Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             

Lys 
    

<210>   12
<211>   214
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Light chain

<400>   12
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      

Thr Ala Arg Ile Thr Cys Gly Gly Asn Ile Ile Gly Ser Lys Leu Val 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Asp Asp Gly Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp Pro 
                85                  90                  95      

Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         

Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             

Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 

Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 

Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     

Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         

Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             

Ala Pro Thr Glu Cys Ser 
    210                 

