                         SEQUENCE LISTING

<110>  Ultimovacs AB
 
<120>  A Conjugate

<130>  PN838260WO

<150>  EP21178648.8
<151>  2021-06-09

<160>  178    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala 
            20                  25                  30  


<210>  2
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  3
<211>  1314
<212>  PRT
<213>  Clostridium tetani

<400>  3

Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val Asn Asn Asp 
1               5                   10                  15      


Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu Asp Ile Tyr 
            20                  25                  30          


Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val Pro Glu Arg 
        35                  40                  45              


Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro Ser Ser Leu 
    50                  55                  60                  


Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu Arg Thr Asp 
65                  70                  75                  80  


Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn Arg 
                85                  90                  95      


Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp Lys Ile Ile Asn 
            100                 105                 110         


Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu Leu Asp Lys Phe Asp 
        115                 120                 125             


Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu Glu Gln Asp Pro Ser 
    130                 135                 140                 


Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile Ile Phe Gly 
145                 150                 155                 160 


Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile Val Leu Arg 
                165                 170                 175     


Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe Gly Ser Ile 
            180                 185                 190         


Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe Asp Asn Val 
        195                 200                 205             


Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys Tyr Phe Gln 
    210                 215                 220                 


Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His Gly 
225                 230                 235                 240 


Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile Pro Ser Lys Gln 
                245                 250                 255     


Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu Glu Leu Phe 
            260                 265                 270         


Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys Asn 
        275                 280                 285             


Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys 
    290                 295                 300                 


Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile Asp Ile Asp Ser 
305                 310                 315                 320 


Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys Asp Ser Asn 
                325                 330                 335     


Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu Tyr Asn Ser 
            340                 345                 350         


Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys Phe Asn Ile 
        355                 360                 365             


Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His Asp Pro Val Lys Ile 
    370                 375                 380                 


Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu Gly Phe Asn 
385                 390                 395                 400 


Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln Asn Met Arg 
                405                 410                 415     


Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly Leu Val Ser 
            420                 425                 430         


Lys Leu Ile Gly Leu Cys Lys Lys Ile Ile Pro Pro Thr Asn Ile Arg 
        435                 440                 445             


Glu Asn Leu Tyr Asn Arg Thr Ala Ser Leu Thr Asp Leu Gly Gly Glu 
    450                 455                 460                 


Leu Cys Ile Lys Ile Lys Asn Glu Asp Leu Thr Phe Ile Ala Glu Lys 
465                 470                 475                 480 


Asn Ser Phe Ser Glu Glu Pro Phe Gln Asp Glu Ile Val Ser Tyr Asn 
                485                 490                 495     


Thr Lys Asn Lys Pro Leu Asn Phe Asn Tyr Ser Leu Asp Lys Ile Ile 
            500                 505                 510         


Val Asp Tyr Asn Leu Gln Ser Lys Ile Thr Leu Pro Asn Asp Arg Thr 
        515                 520                 525             


Thr Pro Val Thr Lys Gly Ile Pro Tyr Ala Pro Glu Tyr Lys Ser Asn 
    530                 535                 540                 


Ala Ala Ser Thr Ile Glu Ile His Asn Ile Asp Asp Asn Thr Ile Tyr 
545                 550                 555                 560 


Gln Tyr Leu Tyr Ala Gln Lys Ser Pro Thr Thr Leu Gln Arg Ile Thr 
                565                 570                 575     


Met Thr Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr 
            580                 585                 590         


Ser Tyr Phe Pro Ser Val Ile Ser Lys Val Asn Gln Gly Ala Gln Gly 
        595                 600                 605             


Ile Leu Phe Leu Gln Trp Val Arg Asp Ile Ile Asp Asp Phe Thr Asn 
    610                 615                 620                 


Glu Ser Ser Gln Lys Thr Thr Ile Asp Lys Ile Ser Asp Val Ser Thr 
625                 630                 635                 640 


Ile Val Pro Tyr Ile Gly Pro Ala Leu Asn Ile Val Lys Gln Gly Tyr 
                645                 650                 655     


Glu Gly Asn Phe Ile Gly Ala Leu Glu Thr Thr Gly Val Val Leu Leu 
            660                 665                 670         


Leu Glu Tyr Ile Pro Glu Ile Thr Leu Pro Val Ile Ala Ala Leu Ser 
        675                 680                 685             


Ile Ala Glu Ser Ser Thr Gln Lys Glu Lys Ile Ile Lys Thr Ile Asp 
    690                 695                 700                 


Asn Phe Leu Glu Lys Arg Tyr Glu Lys Trp Ile Glu Val Tyr Lys Leu 
705                 710                 715                 720 


Val Lys Ala Lys Trp Leu Gly Thr Val Asn Thr Gln Phe Gln Lys Arg 
                725                 730                 735     


Ser Tyr Gln Met Tyr Arg Ser Leu Glu Tyr Gln Val Asp Ala Ile Lys 
            740                 745                 750         


Lys Ile Ile Asp Tyr Glu Tyr Lys Ile Tyr Ser Gly Pro Asp Lys Glu 
        755                 760                 765             


Gln Ile Ala Asp Glu Ile Asn Asn Leu Lys Asn Lys Leu Glu Glu Lys 
    770                 775                 780                 


Ala Asn Lys Ala Met Ile Asn Ile Asn Ile Phe Met Arg Glu Ser Ser 
785                 790                 795                 800 


Arg Ser Phe Leu Val Asn Gln Met Ile Asn Glu Ala Lys Lys Gln Leu 
                805                 810                 815     


Leu Glu Phe Asp Thr Gln Ser Lys Asn Ile Leu Met Gln Tyr Ile Lys 
            820                 825                 830         


Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
        835                 840                 845             


Lys Ile Asn Lys Val Phe Ser Thr Pro Ile Pro Phe Ser Tyr Ser Lys 
    850                 855                 860                 


Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile Leu 
865                 870                 875                 880 


Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser 
                885                 890                 895     


Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln 
            900                 905                 910         


Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu 
        915                 920                 925             


Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn Asp 
    930                 935                 940                 


Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
945                 950                 955                 960 


Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile 
                965                 970                 975     


Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser Val 
            980                 985                 990         


Ser Leu Lys Gly Asn Asn Leu Ile  Trp Thr Leu Lys Asp  Ser Ala Gly 
        995                 1000                 1005             


Glu Val  Arg Gln Ile Thr Phe  Arg Asp Leu Pro Asp  Lys Phe Asn 
    1010                 1015                 1020             


Ala Tyr  Leu Ala Asn Lys Trp  Val Phe Ile Thr Ile  Thr Asn Asp 
    1025                 1030                 1035             


Arg Leu  Ser Ser Ala Asn Leu  Tyr Ile Asn Gly Val  Leu Met Gly 
    1040                 1045                 1050             


Ser Ala  Glu Ile Thr Gly Leu  Gly Ala Ile Arg Glu  Asp Asn Asn 
    1055                 1060                 1065             


Ile Thr  Leu Lys Leu Asp Arg  Cys Asn Asn Asn Asn  Gln Tyr Val 
    1070                 1075                 1080             


Ser Ile  Asp Lys Phe Arg Ile  Phe Cys Lys Ala Leu  Asn Pro Lys 
    1085                 1090                 1095             


Glu Ile  Glu Lys Leu Tyr Thr  Ser Tyr Leu Ser Ile  Thr Phe Leu 
    1100                 1105                 1110             


Arg Asp  Phe Trp Gly Asn Pro  Leu Arg Tyr Asp Thr  Glu Tyr Tyr 
    1115                 1120                 1125             


Leu Ile  Pro Val Ala Ser Ser  Ser Lys Asp Val Gln  Leu Lys Asn 
    1130                 1135                 1140             


Ile Thr  Asp Tyr Met Tyr Leu  Thr Asn Ala Pro Ser  Tyr Thr Asn 
    1145                 1150                 1155             


Gly Lys  Leu Asn Ile Tyr Tyr  Arg Arg Leu Tyr Asn  Gly Leu Lys 
    1160                 1165                 1170             


Phe Ile  Ile Lys Arg Tyr Thr  Pro Asn Asn Glu Ile  Asp Ser Phe 
    1175                 1180                 1185             


Val Lys  Ser Gly Asp Phe Ile  Lys Leu Tyr Val Ser  Tyr Asn Asn 
    1190                 1195                 1200             


Asn Glu  His Ile Val Gly Tyr  Pro Lys Asp Gly Asn  Ala Phe Asn 
    1205                 1210                 1215             


Asn Leu  Asp Arg Ile Leu Arg  Val Gly Tyr Asn Ala  Pro Gly Ile 
    1220                 1225                 1230             


Pro Leu  Tyr Lys Lys Met Glu  Ala Val Lys Leu Arg  Asp Leu Lys 
    1235                 1240                 1245             


Thr Tyr  Ser Val Gln Leu Lys  Leu Tyr Asp Asp Lys  Asn Ala Ser 
    1250                 1255                 1260             


Leu Gly  Leu Val Gly Thr His  Asn Gly Gln Ile Gly  Asn Asp Pro 
    1265                 1270                 1275             


Asn Arg  Asp Ile Leu Ile Ala  Ser Asn Trp Tyr Phe  Asn His Leu 
    1280                 1285                 1290             


Lys Asp  Lys Ile Leu Gly Cys  Asp Trp Tyr Phe Val  Pro Thr Asp 
    1295                 1300                 1305             


Glu Gly  Trp Thr Asn Asp 
    1310                 


<210>  4
<211>  456
<212>  PRT
<213>  Clostridium tetani

<400>  4

Pro Ile Thr Ile Asn Asn Phe Arg Tyr Ser Asp Pro Val Asn Asn Asp 
1               5                   10                  15      


Thr Ile Ile Met Met Glu Pro Pro Tyr Cys Lys Gly Leu Asp Ile Tyr 
            20                  25                  30          


Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Val Pro Glu Arg 
        35                  40                  45              


Tyr Glu Phe Gly Thr Lys Pro Glu Asp Phe Asn Pro Pro Ser Ser Leu 
    50                  55                  60                  


Ile Glu Gly Ala Ser Glu Tyr Tyr Asp Pro Asn Tyr Leu Arg Thr Asp 
65                  70                  75                  80  


Ser Asp Lys Asp Arg Phe Leu Gln Thr Met Val Lys Leu Phe Asn Arg 
                85                  90                  95      


Ile Lys Asn Asn Val Ala Gly Glu Ala Leu Leu Asp Lys Ile Ile Asn 
            100                 105                 110         


Ala Ile Pro Tyr Leu Gly Asn Ser Tyr Ser Leu Leu Asp Lys Phe Asp 
        115                 120                 125             


Thr Asn Ser Asn Ser Val Ser Phe Asn Leu Leu Glu Gln Asp Pro Ser 
    130                 135                 140                 


Gly Ala Thr Thr Lys Ser Ala Met Leu Thr Asn Leu Ile Ile Phe Gly 
145                 150                 155                 160 


Pro Gly Pro Val Leu Asn Lys Asn Glu Val Arg Gly Ile Val Leu Arg 
                165                 170                 175     


Val Asp Asn Lys Asn Tyr Phe Pro Cys Arg Asp Gly Phe Gly Ser Ile 
            180                 185                 190         


Met Gln Met Ala Phe Cys Pro Glu Tyr Val Pro Thr Phe Asp Asn Val 
        195                 200                 205             


Ile Glu Asn Ile Thr Ser Leu Thr Ile Gly Lys Ser Lys Tyr Phe Gln 
    210                 215                 220                 


Asp Pro Ala Leu Leu Leu Met His Glu Leu Ile His Val Leu His Gly 
225                 230                 235                 240 


Leu Tyr Gly Met Gln Val Ser Ser His Glu Ile Ile Pro Ser Lys Gln 
                245                 250                 255     


Glu Ile Tyr Met Gln His Thr Tyr Pro Ile Ser Ala Glu Glu Leu Phe 
            260                 265                 270         


Thr Phe Gly Gly Gln Asp Ala Asn Leu Ile Ser Ile Asp Ile Lys Asn 
        275                 280                 285             


Asp Leu Tyr Glu Lys Thr Leu Asn Asp Tyr Lys Ala Ile Ala Asn Lys 
    290                 295                 300                 


Leu Ser Gln Val Thr Ser Cys Asn Asp Pro Asn Ile Asp Ile Asp Ser 
305                 310                 315                 320 


Tyr Lys Gln Ile Tyr Gln Gln Lys Tyr Gln Phe Asp Lys Asp Ser Asn 
                325                 330                 335     


Gly Gln Tyr Ile Val Asn Glu Asp Lys Phe Gln Ile Leu Tyr Asn Ser 
            340                 345                 350         


Ile Met Tyr Gly Phe Thr Glu Ile Glu Leu Gly Lys Lys Phe Asn Ile 
        355                 360                 365             


Lys Thr Arg Leu Ser Tyr Phe Ser Met Asn His Asp Pro Val Lys Ile 
    370                 375                 380                 


Pro Asn Leu Leu Asp Asp Thr Ile Tyr Asn Asp Thr Glu Gly Phe Asn 
385                 390                 395                 400 


Ile Glu Ser Lys Asp Leu Lys Ser Glu Tyr Lys Gly Gln Asn Met Arg 
                405                 410                 415     


Val Asn Thr Asn Ala Phe Arg Asn Val Asp Gly Ser Gly Leu Val Ser 
            420                 425                 430         


Lys Leu Ile Gly Leu Cys Lys Lys Ile Ile Pro Pro Thr Asn Ile Arg 
        435                 440                 445             


Glu Asn Leu Tyr Asn Arg Thr Ala 
    450                 455     


<210>  5
<211>  858
<212>  PRT
<213>  Clostridium tetani

<400>  5

Ser Leu Thr Asp Leu Gly Gly Glu Leu Cys Ile Lys Ile Lys Asn Glu 
1               5                   10                  15      


Asp Leu Thr Phe Ile Ala Glu Lys Asn Ser Phe Ser Glu Glu Pro Phe 
            20                  25                  30          


Gln Asp Glu Ile Val Ser Tyr Asn Thr Lys Asn Lys Pro Leu Asn Phe 
        35                  40                  45              


Asn Tyr Ser Leu Asp Lys Ile Ile Val Asp Tyr Asn Leu Gln Ser Lys 
    50                  55                  60                  


Ile Thr Leu Pro Asn Asp Arg Thr Thr Pro Val Thr Lys Gly Ile Pro 
65                  70                  75                  80  


Tyr Ala Pro Glu Tyr Lys Ser Asn Ala Ala Ser Thr Ile Glu Ile His 
                85                  90                  95      


Asn Ile Asp Asp Asn Thr Ile Tyr Gln Tyr Leu Tyr Ala Gln Lys Ser 
            100                 105                 110         


Pro Thr Thr Leu Gln Arg Ile Thr Met Thr Asn Ser Val Asp Asp Ala 
        115                 120                 125             


Leu Ile Asn Ser Thr Lys Ile Tyr Ser Tyr Phe Pro Ser Val Ile Ser 
    130                 135                 140                 


Lys Val Asn Gln Gly Ala Gln Gly Ile Leu Phe Leu Gln Trp Val Arg 
145                 150                 155                 160 


Asp Ile Ile Asp Asp Phe Thr Asn Glu Ser Ser Gln Lys Thr Thr Ile 
                165                 170                 175     


Asp Lys Ile Ser Asp Val Ser Thr Ile Val Pro Tyr Ile Gly Pro Ala 
            180                 185                 190         


Leu Asn Ile Val Lys Gln Gly Tyr Glu Gly Asn Phe Ile Gly Ala Leu 
        195                 200                 205             


Glu Thr Thr Gly Val Val Leu Leu Leu Glu Tyr Ile Pro Glu Ile Thr 
    210                 215                 220                 


Leu Pro Val Ile Ala Ala Leu Ser Ile Ala Glu Ser Ser Thr Gln Lys 
225                 230                 235                 240 


Glu Lys Ile Ile Lys Thr Ile Asp Asn Phe Leu Glu Lys Arg Tyr Glu 
                245                 250                 255     


Lys Trp Ile Glu Val Tyr Lys Leu Val Lys Ala Lys Trp Leu Gly Thr 
            260                 265                 270         


Val Asn Thr Gln Phe Gln Lys Arg Ser Tyr Gln Met Tyr Arg Ser Leu 
        275                 280                 285             


Glu Tyr Gln Val Asp Ala Ile Lys Lys Ile Ile Asp Tyr Glu Tyr Lys 
    290                 295                 300                 


Ile Tyr Ser Gly Pro Asp Lys Glu Gln Ile Ala Asp Glu Ile Asn Asn 
305                 310                 315                 320 


Leu Lys Asn Lys Leu Glu Glu Lys Ala Asn Lys Ala Met Ile Asn Ile 
                325                 330                 335     


Asn Ile Phe Met Arg Glu Ser Ser Arg Ser Phe Leu Val Asn Gln Met 
            340                 345                 350         


Ile Asn Glu Ala Lys Lys Gln Leu Leu Glu Phe Asp Thr Gln Ser Lys 
        355                 360                 365             


Asn Ile Leu Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile 
    370                 375                 380                 


Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys Val Phe Ser Thr 
385                 390                 395                 400 


Pro Ile Pro Phe Ser Tyr Ser Lys Asn Leu Asp Cys Trp Val Asp Asn 
                405                 410                 415     


Glu Glu Asp Ile Asp Val Ile Leu Lys Lys Ser Thr Ile Leu Asn Leu 
            420                 425                 430         


Asp Ile Asn Asn Asp Ile Ile Ser Asp Ile Ser Gly Phe Asn Ser Ser 
        435                 440                 445             


Val Ile Thr Tyr Pro Asp Ala Gln Leu Val Pro Gly Ile Asn Gly Lys 
    450                 455                 460                 


Ala Ile His Leu Val Asn Asn Glu Ser Ser Glu Val Ile Val His Lys 
465                 470                 475                 480 


Ala Met Asp Ile Glu Tyr Asn Asp Met Phe Asn Asn Phe Thr Val Ser 
                485                 490                 495     


Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gln Tyr 
            500                 505                 510         


Gly Thr Asn Glu Tyr Ser Ile Ile Ser Ser Met Lys Lys His Ser Leu 
        515                 520                 525             


Ser Ile Gly Ser Gly Trp Ser Val Ser Leu Lys Gly Asn Asn Leu Ile 
    530                 535                 540                 


Trp Thr Leu Lys Asp Ser Ala Gly Glu Val Arg Gln Ile Thr Phe Arg 
545                 550                 555                 560 


Asp Leu Pro Asp Lys Phe Asn Ala Tyr Leu Ala Asn Lys Trp Val Phe 
                565                 570                 575     


Ile Thr Ile Thr Asn Asp Arg Leu Ser Ser Ala Asn Leu Tyr Ile Asn 
            580                 585                 590         


Gly Val Leu Met Gly Ser Ala Glu Ile Thr Gly Leu Gly Ala Ile Arg 
        595                 600                 605             


Glu Asp Asn Asn Ile Thr Leu Lys Leu Asp Arg Cys Asn Asn Asn Asn 
    610                 615                 620                 


Gln Tyr Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn 
625                 630                 635                 640 


Pro Lys Glu Ile Glu Lys Leu Tyr Thr Ser Tyr Leu Ser Ile Thr Phe 
                645                 650                 655     


Leu Arg Asp Phe Trp Gly Asn Pro Leu Arg Tyr Asp Thr Glu Tyr Tyr 
            660                 665                 670         


Leu Ile Pro Val Ala Ser Ser Ser Lys Asp Val Gln Leu Lys Asn Ile 
        675                 680                 685             


Thr Asp Tyr Met Tyr Leu Thr Asn Ala Pro Ser Tyr Thr Asn Gly Lys 
    690                 695                 700                 


Leu Asn Ile Tyr Tyr Arg Arg Leu Tyr Asn Gly Leu Lys Phe Ile Ile 
705                 710                 715                 720 


Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe Val Lys Ser Gly 
                725                 730                 735     


Asp Phe Ile Lys Leu Tyr Val Ser Tyr Asn Asn Asn Glu His Ile Val 
            740                 745                 750         


Gly Tyr Pro Lys Asp Gly Asn Ala Phe Asn Asn Leu Asp Arg Ile Leu 
        755                 760                 765             


Arg Val Gly Tyr Asn Ala Pro Gly Ile Pro Leu Tyr Lys Lys Met Glu 
    770                 775                 780                 


Ala Val Lys Leu Arg Asp Leu Lys Thr Tyr Ser Val Gln Leu Lys Leu 
785                 790                 795                 800 


Tyr Asp Asp Lys Asn Ala Ser Leu Gly Leu Val Gly Thr His Asn Gly 
                805                 810                 815     


Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu Ile Ala Ser Asn Trp 
            820                 825                 830         


Tyr Phe Asn His Leu Lys Asp Lys Ile Leu Gly Cys Asp Trp Tyr Phe 
        835                 840                 845             


Val Pro Thr Asp Glu Gly Trp Thr Asn Asp 
    850                 855             


<210>  6
<211>  8
<212>  PRT
<213>  Clostridium tetani

<400>  6

Gly Ile Thr Glu Leu Lys Lys Leu 
1               5               


<210>  7
<211>  18
<212>  PRT
<213>  Clostridium tetani

<400>  7

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  8
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  9
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 
1               5                   10                  15      


Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 
            20                  25                  30          


Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 
        35                  40                  45              


Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 
    50                  55                  60                  


Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 
65                  70                  75                  80  


Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 
                85                  90                  95      


Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 
            100                 105                 110         


Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 
        115                 120                 125             


Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 
    130                 135                 140                 


Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 
145                 150                 155                 160 


Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 
                165                 170                 175     


Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 
            180                 185                 190         


Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 
        195                 200                 205             


Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 
    210                 215                 220                 


Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 
225                 230                 235                 240 


Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 
                245                 250                 255     


Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 
            260                 265                 270         


Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 
        275                 280                 285             


Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 
    290                 295                 300                 


Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 
305                 310                 315                 320 


Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys 
                325                 330                 335     


Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys 
            340                 345                 350         


Ala His Gln Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu Ile 
        355                 360                 365             


Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln 
    370                 375                 380                 


Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys 
385                 390                 395                 400 


Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys 
                405                 410                 415     


Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys His 
            420                 425                 430         


Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly 
        435                 440                 445             


Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser 
    450                 455                 460                 


Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp Lys 
465                 470                 475                 480 


Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala 
                485                 490                 495     


Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys 
            500                 505                 510         


Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu 
        515                 520                 525             


Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln 
    530                 535                 540                 


Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn 
545                 550                 555                 560 


Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr Pro 
                565                 570                 575     


Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu 
            580                 585                 590         


Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn His Lys Lys Trp 
        595                 600                 605             


Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala 
    610                 615                 620                 


Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile Gln Phe Lys Tyr 
625                 630                 635                 640 


Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys 
                645                 650                 655     


Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg 
            660                 665                 670         


Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln 
        675                 680                 685             


Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile 
    690                 695                 700                 


Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val Asp 
705                 710                 715                 720 


Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg 
                725                 730                 735     


Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala 
            740                 745                 750         


Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr Ile 
        755                 760                 765             


Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu Leu 
    770                 775                 780                 


Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ser 
785                 790                 795                 800 


Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser Leu Ala Arg Leu 
                805                 810                 815     


Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe Leu Tyr Asp Asp 
            820                 825                 830         


Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val 
        835                 840                 845             


Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile 
    850                 855                 860                 


Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile Arg Arg Leu Met 
865                 870                 875                 880 


Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys 
                885                 890                 895     


Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu 
            900                 905                 910         


Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser Glu Leu Pro Val 
        915                 920                 925             


Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu Glu Pro Met Leu 
    930                 935                 940                 


Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr 
945                 950                 955                 960 


His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu Lys 
                965                 970                 975     


Leu Ala Glu Ala Glu Arg Val Gly Leu His Lys Val Phe Lys Leu Gln 
            980                 985                 990         


Thr Ser Leu Thr Cys Asn Ser Met  Val Leu Phe Asp His  Val Gly Cys 
        995                 1000                 1005             


Leu Lys  Lys Tyr Asp Thr Val  Leu Asp Ile Leu Arg  Asp Phe Phe 
    1010                 1015                 1020             


Glu Leu  Arg Leu Lys Tyr Tyr  Gly Leu Arg Lys Glu  Trp Leu Leu 
    1025                 1030                 1035             


Gly Met  Leu Gly Ala Glu Ser  Ala Lys Leu Asn Asn  Gln Ala Arg 
    1040                 1045                 1050             


Phe Ile  Leu Glu Lys Ile Asp  Gly Lys Ile Ile Ile  Glu Asn Lys 
    1055                 1060                 1065             


Pro Lys  Lys Glu Leu Ile Lys  Val Leu Ile Gln Arg  Gly Tyr Asp 
    1070                 1075                 1080             


Ser Asp  Pro Val Lys Ala Trp  Lys Glu Ala Gln Gln  Lys Val Pro 
    1085                 1090                 1095             


Asp Glu  Glu Glu Asn Glu Glu  Ser Asp Asn Glu Lys  Glu Thr Glu 
    1100                 1105                 1110             


Lys Ser  Asp Ser Val Thr Asp  Ser Gly Pro Thr Phe  Asn Tyr Leu 
    1115                 1120                 1125             


Leu Asp  Met Pro Leu Trp Tyr  Leu Thr Lys Glu Lys  Lys Asp Glu 
    1130                 1135                 1140             


Leu Cys  Arg Leu Arg Asn Glu  Lys Glu Gln Glu Leu  Asp Thr Leu 
    1145                 1150                 1155             


Lys Arg  Lys Ser Pro Ser Asp  Leu Trp Lys Glu Asp  Leu Ala Thr 
    1160                 1165                 1170             


Phe Ile  Glu Glu Leu Glu Ala  Val Glu Ala Lys Glu  Lys Gln Asp 
    1175                 1180                 1185             


Glu Gln  Val Gly Leu Pro Gly  Lys Gly Gly Lys Ala  Lys Gly Lys 
    1190                 1195                 1200             


Lys Thr  Gln Met Ala Glu Val  Leu Pro Ser Pro Arg  Gly Gln Arg 
    1205                 1210                 1215             


Val Ile  Pro Arg Ile Thr Ile  Glu Met Lys Ala Glu  Ala Glu Lys 
    1220                 1225                 1230             


Lys Asn  Lys Lys Lys Ile Lys  Asn Glu Asn Thr Glu  Gly Ser Pro 
    1235                 1240                 1245             


Gln Glu  Asp Gly Val Glu Leu  Glu Gly Leu Lys Gln  Arg Leu Glu 
    1250                 1255                 1260             


Lys Lys  Gln Lys Arg Glu Pro  Gly Thr Lys Thr Lys  Lys Gln Thr 
    1265                 1270                 1275             


Thr Leu  Ala Phe Lys Pro Ile  Lys Lys Gly Lys Lys  Arg Asn Pro 
    1280                 1285                 1290             


Trp Ser  Asp Ser Glu Ser Asp  Arg Ser Ser Asp Glu  Ser Asn Phe 
    1295                 1300                 1305             


Asp Val  Pro Pro Arg Glu Thr  Glu Pro Arg Arg Ala  Ala Thr Lys 
    1310                 1315                 1320             


Thr Lys  Phe Thr Met Asp Leu  Asp Ser Asp Glu Asp  Phe Ser Asp 
    1325                 1330                 1335             


Phe Asp  Glu Lys Thr Asp Asp  Glu Asp Phe Val Pro  Ser Asp Ala 
    1340                 1345                 1350             


Ser Pro  Pro Lys Thr Lys Thr  Ser Pro Lys Leu Ser  Asn Lys Glu 
    1355                 1360                 1365             


Leu Lys  Pro Gln Lys Ser Val  Val Ser Asp Leu Glu  Ala Asp Asp 
    1370                 1375                 1380             


Val Lys  Gly Ser Val Pro Leu  Ser Ser Ser Pro Pro  Ala Thr His 
    1385                 1390                 1395             


Phe Pro  Asp Glu Thr Glu Ile  Thr Asn Pro Val Pro  Lys Lys Asn 
    1400                 1405                 1410             


Val Thr  Val Lys Lys Thr Ala  Ala Lys Ser Gln Ser  Ser Thr Ser 
    1415                 1420                 1425             


Thr Thr  Gly Ala Lys Lys Arg  Ala Ala Pro Lys Gly  Thr Lys Arg 
    1430                 1435                 1440             


Asp Pro  Ala Leu Asn Ser Gly  Val Ser Gln Lys Pro  Asp Pro Ala 
    1445                 1450                 1455             


Lys Thr  Lys Asn Arg Arg Lys  Arg Lys Pro Ser Thr  Ser Asp Asp 
    1460                 1465                 1470             


Ser Asp  Ser Asn Phe Glu Lys  Ile Val Ser Lys Ala  Val Thr Ser 
    1475                 1480                 1485             


Lys Lys  Ser Lys Gly Glu Ser  Asp Asp Phe His Met  Asp Phe Asp 
    1490                 1495                 1500             


Ser Ala  Val Ala Pro Arg Ala  Lys Ser Val Arg Ala  Lys Lys Pro 
    1505                 1510                 1515             


Ile Lys  Tyr Leu Glu Glu Ser  Asp Glu Asp Asp Leu  Phe 
    1520                 1525                 1530     


<210>  10
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  11
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro 
1               5                   10                  


<210>  13
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly 
1               5                   10                  


<210>  14
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  15

Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  18

Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  19

Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  25

Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His 
1               5                   10                  


<210>  27
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  27

Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
1               5                   10                  


<210>  28
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala 
1               5                   10                  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  35

Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala 
1               5                   10                  15  


<210>  36
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  37
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  38
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val Tyr Asp Pro Leu 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu Leu Ser 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Thr Gly Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
1               5                   10                  15  


<210>  45
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Ala Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met 
1               5                   10                  15      


Pro Phe Ala Thr Pro Met Glu Ala Glu Leu Ala 
            20                  25          


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ala Glu Lys Tyr Ala Arg Val Arg Ala Lys Cys 
            20                  25                  


<210>  47
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Ala Arg Trp Trp Asn Tyr Ala Arg Thr Glu Asp Phe Phe Gln Gln Gln 
1               5                   10                  15      


Pro Pro Pro Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys Val Tyr Asp 
            20                  25                  30          


Pro Leu 
        


<210>  48
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Ala Arg Trp Trp Leu Leu His Glu Thr Asp Ser Ala Val Ala Ala Ala 
1               5                   10                  15      


Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
            20                  25                  30      


<210>  49
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Ala Arg Trp Trp Ser Leu Ser Leu Gly Phe Leu Phe Leu Ala Ala Ala 
1               5                   10                  15      


Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala 
            20                  25                  30      


<210>  50
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Ala Arg Trp Trp Gly Met Pro Glu Gly Asp Leu Val Tyr Thr Gly Asn 
1               5                   10                  15      


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser 
            20                  25              


<210>  51
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Ala Arg Trp Trp Lys Val Phe Arg Gly Asn Lys Val Lys Asn Tyr Thr 
1               5                   10                  15      


Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu 
            20                  25              


<210>  52
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Glu Arg Leu Thr Ser Arg Val Lys Ala Leu Phe Ser Val Leu 
1               5                   10                  15  


<210>  54
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  54

Ala Val Gly Ala Leu Glu Gly Ser Arg Asn Gln Asp Trp Leu Gly Val 
1               5                   10                  15      


Pro Arg Gln Leu 
            20  


<210>  55
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (18)..(18)
<223>  Cyclohexyl-Ala

<220>
<221>  u
<222>  (27)..(27)
<223>  D-Ala

<400>  55

Ala Arg Trp Trp Trp Met His His Asn Met Asp Leu Ile Gly Gly Ala 
1               5                   10                  15      


Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Xaa 
            20                  25          


<210>  56
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Arg Trp Trp 
1               


<210>  57
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  57

Trp Met His His Asn Met Asp Leu Ile 
1               5                   


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (3)..(3)
<223>  Cyclohexyl-Ala

<220>
<221>  U
<222>  (12)..(12)
<223>  D-Ala

<400>  58

Ala Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Xaa 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  59

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10          


<210>  61
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10                  


<210>  62
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  62

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  63
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  63

Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10                  15      


<210>  64
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  64

Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  15      


<210>  65
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  65

Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu 
1               5                   10                  15      


Glu Ser 
        


<210>  66
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  66

Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser 
1               5                   10                  15      


Lys Ile 
        


<210>  67
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys 
1               5                   10                  15      


Lys Leu Glu Ser 
            20  


<210>  68
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  68

Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu 
1               5                   10                  15      


Glu Ser Lys Ile 
            20  


<210>  69
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  69

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys 
1               5                   10                  15      


Lys Leu Glu Ser Lys Ile 
            20          


<210>  70
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  70

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ser Thr 
            20  


<210>  71
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  71

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ser 
            


<210>  72
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  72

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  73
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  73

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val 
    


<210>  74
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  74

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


<210>  75
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  75

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn 
1               5                   10                  15  


<210>  76
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  76

Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn 
1               5                   10                  


<210>  77
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  77

Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  


<210>  78
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  K
<222>  (8)..(8)
<223>  Formylated Lys8

<400>  78

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  79
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  K
<222>  (9)..(9)
<223>  Ly9 formylated

<400>  79

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  80
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  K
<222>  (13)..(13)
<223>  Lys13 formylated

<400>  80

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  81
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  K
<222>  (8)..(8)
<223>  Lys8 formylated

<220>
<221>  K
<222>  (9)..(9)
<223>  Lys9 formylated

<400>  81

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  82
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  K
<222>  (9)..(9)
<223>  Formylated Lys9

<220>
<221>  K
<222>  (13)..(13)
<223>  Formylated Lys13

<400>  82

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile 
1               5                   10                  


<210>  83
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  84
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  84

Phe Ala Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  85
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  85

Phe Ile Ala Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  86
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  86

Phe Ile Gly Ile Thr Ala Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  87
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  87

Phe Ile Gly Ile Thr Glu Ala Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  88
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  88

Phe Ile Gly Ile Thr Glu Leu Ala Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  89
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  89

Phe Ile Gly Ile Thr Glu Leu Lys Ala Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  90
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  90

Phe Ile Gly Ile Thr Glu Leu Lys Lys Ala Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  91
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  91

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Ala Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  92
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  92

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ala Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  93
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  93

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Ala Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  94
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  94

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ala Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  95
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  95

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Ala Lys 
1               5                   10                  15      


Val Phe 
        


<210>  96
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  96

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Ala 
1               5                   10                  15      


Val Phe 
        


<210>  97
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  97

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Ala Phe 
        


<210>  98
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  98

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Ala 
        


<210>  99
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  99

Tyr Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  100
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  100

Phe Leu Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  101
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  101

Phe Ile Ser Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  102
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  102

Phe Ile Gly Leu Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  103
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  103

Phe Ile Gly Ile Ser Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  104
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  104

Phe Ile Gly Ile Thr Asp Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  105
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  105

Phe Ile Gly Ile Thr Glu Ile Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  106
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  106

Phe Ile Gly Ile Thr Glu Leu Arg Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  107
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  107

Phe Ile Gly Ile Thr Glu Leu Lys Arg Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  108
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  108

Phe Ile Gly Ile Thr Glu Leu Lys Lys Ile Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  109
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  109

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Thr Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  110
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  110

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Arg Ile Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  111
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  111

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Leu Asn Lys 
1               5                   10                  15      


Val Phe 
        


<210>  112
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  112

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Gln Lys 
1               5                   10                  15      


Val Phe 
        


<210>  113
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  113

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Arg 
1               5                   10                  15      


Val Phe 
        


<210>  114
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  114

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Leu Phe 
        


<210>  115
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  115

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Tyr 
        


<210>  116
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  116

Leu Ser Glu Ala Glu Val Arg Gln His Arg Glu Ala Arg Pro Ala Leu 
1               5                   10                  15      


Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys Pro Asp Gly Leu 
            20                  25                  30  


<210>  117
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  117

His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
1               5                   10                  15      


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr 
            20                  25                  30  


<210>  118
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  118

Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile Pro 
1               5                   10                  15      


Gln Asp Arg Leu Thr Arg Val Ile Ala Ser Ile Ile Lys Pro 
            20                  25                  30  


<210>  119
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  119

Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val 
1               5                   10      


<210>  120
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  120

His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
1               5                   10                  15      


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
            20                  25                  30          


Gly Ala Arg Thr Phe Arg Arg Glu Lys 
        35                  40      


<210>  121
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  121

Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys 
1               5                   10                  15      


Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr 
            20                  25              


<210>  122
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  122

Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys 
1               5                   10                  15      


Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val 
            20                  25                  


<210>  123
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  123

Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys 
1               5                   10                  15      


Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp 
            20                  25          


<210>  124
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  124

Ala Glu Val Arg Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser 
1               5                   10                  15      


Arg Leu Arg Phe Ile Pro Lys Pro Asp Gly Leu 
            20                  25          


<210>  125
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  125

Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu 
1               5                   10                  15      


Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg Ala Asn Pro 
            20                  25                  30          


Ile Leu Leu Trp Gln Pro Ile Pro Val 
        35                  40      


<210>  126
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  126

Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys 
1               5                   10                  15      


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127

Ala Glu Lys Tyr Ala Arg Val Arg Ala Lys 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128

Ala Ala Lys Tyr Ala Arg Val Arg Ala Lys 
1               5                   10  


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129

Ala Ala Lys Tyr Ala Arg Val Arg Ala Lys Cys 
1               5                   10      


<210>  130
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  130

Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
1               5                   10                  15      


<210>  131
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  131

Glu Ala Glu Val Arg Gln His Arg Glu Ala Arg Pro Ala Leu Leu 
1               5                   10                  15  


<210>  132
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  132

Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys Pro 
1               5                   10                  15  


<210>  133
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  133

Thr Ser Arg Leu Arg Phe Ile Pro Lys Pro Asp Gly Leu Arg Pro 
1               5                   10                  15  


<210>  134
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  134

Phe Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp 
1               5                   10                  15  


<210>  135
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  135

Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val Gly 
1               5                   10                  15  


<210>  136
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  136

Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro Glu Leu Tyr 
1               5                   10                  15  


<210>  137
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  137

Pro Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr 
1               5                   10                  


<210>  138
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  138

Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr 
1               5                   10                  15  


<210>  139
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  139

Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
1               5                   10                  15  


<210>  140
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  140

Val Thr Gly Ala Tyr Asp Thr Ile Pro Gln Asp Arg Leu Thr Glu 
1               5                   10                  15  


<210>  141
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  141

Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro 
1               5                   10                  15  


<210>  142
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  142

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ser Ser Ala Phe Ala Asp Val Glu Ala Ala 
            20                  25              


<210>  143
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143

Ala Arg Trp Trp Leu Leu His Glu Thr Asp Ser Ala Val Ala Ala Ala 
1               5                   10                  15      


Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
            20                  25                  30      


<210>  144
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144

Leu Leu His Glu Thr Asp Ser Ala Val Ala Ala Ala Arg Gln Ile Tyr 
1               5                   10                  15      


Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu 
            20                  25          


<210>  145
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ala Glu Lys Tyr Ala Arg Val Arg Ala Lys 
            20                  25              


<210>  146
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146

Phe Ile Gly Ile Thr Glu Leu Lys Lys Leu Glu Ser Lys Ile Asn Lys 
1               5                   10                  15      


Val Phe Ala Glu Lys Tyr Ala Arg Val Arg Ala Lys Cys 
            20                  25                  


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  147

Leu Leu Gly Ala Ser Val Leu Gly Leu 
1               5                   


<210>  148
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  148

Gly Leu Leu Gly Ala Ser Val Leu Gly Leu 
1               5                   10  


<210>  149
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  149

Val Leu Gly Leu Asp Asp Ile His Arg Ala 
1               5                   10  


<210>  150
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  150

Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu 
1               5                   10                  15  


<210>  151
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  151

Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu 
1               5                   10                  15  


<210>  152
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  152

Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly Leu Leu Gly Ala 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  153

Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile 
1               5                   10                  15  


<210>  154
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  154

Ser Ser Ala Phe Ala Asp Val Glu Ala Ala 
1               5                   10  


<210>  155
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  155

Asn Tyr Ala Arg Thr Glu Asp Phe Phe 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  156

Leu Leu His Glu Thr Asp Ser Ala Val 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  157

Ser Leu Ser Leu Gly Phe Leu Phe Leu 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  158

Gly Met Pro Glu Gly Asp Leu Val Tyr 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  159

Lys Val Phe Arg Gly Asn Lys Val Lys 
1               5                   


<210>  160
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  160
gcactgttca gcgtgctcaa ctacgagcgg gcgcggcgcc ccggcctcct gggcgcctct       60

gtgctgggcc tggacgatat ccacagggcc                                        90


<210>  161
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  161
ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga       60

ctccgcttca tccccaagcc tgacgggctg cgg                                    93


<210>  162
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  162
catcgggaag ccaggcccgc cctgctgacg tccagactcc gcttcatccc caagcctgac       60

gggctgcggc cgattgtgaa catggactac                                        90


<210>  163
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  163

Asn Tyr Glu Arg Ala Arg Arg Pro Gly 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  164

Arg Arg Pro Gly Leu Leu Gly Ala Ser 
1               5                   


<210>  165
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  165

Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile 
1               5                   10          


<210>  166
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  166

Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro Lys 
1               5                   10                  15      


Pro Asp Gly Leu 
            20  


<210>  167
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  167

Gln His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu 
1               5                   10                  15  


<210>  168
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  168

Leu Ser Glu Ala Glu Val Arg Gln His Arg Glu Ala Arg Pro Ala 
1               5                   10                  15  


<210>  169
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  169

Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile Pro 
1               5                   10                  15  


<210>  170
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  170

Leu Arg Phe Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn 
1               5                   10                  15  


<210>  171
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  171

Leu Leu Thr Ser Arg Leu Arg Phe Ile
1               5                  


<210>  172
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  172

Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
1               5                   10  


<210>  173
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  173

Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
1               5                   10                  15  


<210>  174
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  174

Arg Ala Glu Arg Leu Thr Ser Arg Val Lys Ala Leu Phe Ser Val 
1               5                   10                  15  


<210>  175
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  175

Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg Pro Gly 
1               5                   10                  15  


<210>  176
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  176

Val Leu Gly Leu Asp Asp Ile His Arg Ala Trp Arg Thr Phe Val 
1               5                   10                  15  


<210>  177
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  177

Arg Pro Ile Val Asn 
1               5   


<210>  178
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  178

Pro Asp Gly Leu 
1               

