                         SEQUENCE LISTING

<110>  OSE IMMUNOTHERAPEUTICS
 
<120>  Humanized anti-CLEC-1A antibodies and antigen-binding fragments 
       thereof and mimetics thereof

<130>  B14493WO - AD/HLQ/CGY

<140>  PCT/EPXXXXXX
<141>  2022-06-08

<150>  EP 21305777.1
<151>  2021-06-08

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  280
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  1

Met Gln Ala Lys Tyr Ser Ser Thr Arg Asp Met Leu Asp Asp Asp Gly 
1               5                   10                  15      


Asp Thr Thr Met Ser Leu His Ser Gln Gly Ser Ala Thr Thr Arg His 
            20                  25                  30          


Pro Glu Pro Arg Arg Thr Glu His Arg Ala Pro Ser Ser Thr Trp Arg 
        35                  40                  45              


Pro Val Ala Leu Thr Leu Leu Thr Leu Cys Leu Val Leu Leu Ile Gly 
    50                  55                  60                  


Leu Ala Ala Leu Gly Leu Leu Phe Phe Gln Tyr Tyr Gln Leu Ser Asn 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Thr 
                85                  90                  95      


Ser Gln Glu Leu Gln Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly 
            100                 105                 110         


Ser Leu Gln His Val Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys 
        115                 120                 125             


Ala Gly Ala His Arg Cys Ser Pro Cys Thr Glu Gln Trp Lys Trp His 
    130                 135                 140                 


Gly Asp Asn Cys Tyr Gln Phe Tyr Lys Asp Ser Lys Ser Trp Glu Asp 
145                 150                 155                 160 


Cys Lys Tyr Phe Cys Leu Ser Glu Asn Ser Thr Met Leu Lys Ile Asn 
                165                 170                 175     


Lys Gln Glu Asp Leu Glu Phe Ala Ala Ser Gln Ser Tyr Ser Glu Phe 
            180                 185                 190         


Phe Tyr Ser Tyr Trp Thr Gly Leu Leu Arg Pro Asp Ser Gly Lys Ala 
        195                 200                 205             


Trp Leu Trp Met Asp Gly Thr Pro Phe Thr Ser Glu Leu Phe His Ile 
    210                 215                 220                 


Ile Ile Asp Val Thr Ser Pro Arg Ser Arg Asp Cys Val Ala Ile Leu 
225                 230                 235                 240 


Asn Gly Met Ile Phe Ser Lys Asp Cys Lys Glu Leu Lys Arg Cys Val 
                245                 250                 255     


Cys Glu Arg Arg Ala Gly Met Val Lys Pro Glu Ser Leu His Val Pro 
            260                 265                 270         


Pro Glu Thr Leu Gly Glu Gly Asp 
        275                 280 


<210>  2
<211>  206
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  2

Tyr Tyr Gln Leu Ser Asn Thr Gly Gln Asp Thr Ile Ser Gln Met Glu 
1               5                   10                  15      


Glu Arg Leu Gly Asn Thr Ser Gln Glu Leu Gln Ser Leu Gln Val Gln 
            20                  25                  30          


Asn Ile Lys Leu Ala Gly Ser Leu Gln His Val Ala Glu Lys Leu Cys 
        35                  40                  45              


Arg Glu Leu Tyr Asn Lys Ala Gly Ala His Arg Cys Ser Pro Cys Thr 
    50                  55                  60                  


Glu Gln Trp Lys Trp His Gly Asp Asn Cys Tyr Gln Phe Tyr Lys Asp 
65                  70                  75                  80  


Ser Lys Ser Trp Glu Asp Cys Lys Tyr Phe Cys Leu Ser Glu Asn Ser 
                85                  90                  95      


Thr Met Leu Lys Ile Asn Lys Gln Glu Asp Leu Glu Phe Ala Ala Ser 
            100                 105                 110         


Gln Ser Tyr Ser Glu Phe Phe Tyr Ser Tyr Trp Thr Gly Leu Leu Arg 
        115                 120                 125             


Pro Asp Ser Gly Lys Ala Trp Leu Trp Met Asp Gly Thr Pro Phe Thr 
    130                 135                 140                 


Ser Glu Leu Phe His Ile Ile Ile Asp Val Thr Ser Pro Arg Ser Arg 
145                 150                 155                 160 


Asp Cys Val Ala Ile Leu Asn Gly Met Ile Phe Ser Lys Asp Cys Lys 
                165                 170                 175     


Glu Leu Lys Arg Cys Val Cys Glu Arg Arg Ala Gly Met Val Lys Pro 
            180                 185                 190         


Glu Ser Leu His Val Pro Pro Glu Thr Leu Gly Glu Gly Asp 
        195                 200                 205     


<210>  3
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  3

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Ala Trp Phe Thr Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Phe Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Phe Thr Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Asp Ala Ser Thr Ile Tyr Ala Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Gly Tyr Tyr Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  6
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Phe Thr Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Asp Ala Ser Thr Ile Tyr Ala Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Gly Tyr Tyr Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  7
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  8
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn His 
            20                  25                  30          


Gly Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Arg Gly Thr Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Met Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  10
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  10

Asn Phe Gly Met Asn 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  11

Trp Ile Asn Thr Asn Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  12

Gly Ala Pro Ala Trp Phe Thr Tyr 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  13

Arg Ala Ser Glu Ser Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  14

Asn Ala Lys Thr Leu Ala Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  15

Gln His His Phe Gly Thr Pro Leu Thr 
1               5                   


<210>  16
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  16

Thr Tyr Gly Ile His 
1               5   


<210>  17
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  17

Val Ile Trp Ser Asp Ala Ser Thr Ile Tyr Ala Ser Ser Leu Lys Ser 
1               5                   10                  15      


<210>  18
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  18

His Gly Gly Tyr Tyr Asn Tyr Phe Asp Tyr 
1               5                   10  


<210>  19
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  19

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  20

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  21

Gln Gln Gly Gln Ser Tyr Trp Thr 
1               5               


<210>  22
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Asp Tyr Val Ile Ser 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  23

Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  24

Gly Gly Ser Ser His Phe Asp Tyr 
1               5               


<210>  25
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  25

Arg Ala Ser Gln Ser Val Asp Asn His Gly Phe Ser Phe Met Asn 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  26

Ala Ala Ser Asn Arg Gly Thr 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  27

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  28
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  29
<211>  326
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  30
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  31
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  31

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  32
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  33
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  33

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  34
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  34

Gly Tyr Thr Phe Thr Asn Phe Gly 
1               5               


<210>  35
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  35

Trp Ile Asn Thr Asn Thr Gly Glu Pro 
1               5                   


<210>  36
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  36

Cys Ala Arg Gly Ala Pro Ala Trp Phe Thr Tyr 
1               5                   10      


<210>  37
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  37

Glu Ser Ile Tyr Ser Tyr 
1               5       


<210>  38
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  38

Asn Ala Lys 
1           


<210>  39
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  39

Gln His His Phe Gly Thr Pro Leu Thr 
1               5                   


<210>  40
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  40

Gly Phe Thr Leu Thr Thr Tyr Gly 
1               5               


<210>  41
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  41

Trp Ser Asp Ala Ser Thr Ile 
1               5           


<210>  42
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  42

Arg His Gly Gly Tyr Tyr Asn Tyr Phe Asp Tyr 
1               5                   10      


<210>  43
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  43

Gln Asn Ile Asn Val Trp 
1               5       


<210>  44
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  44

Lys Ala Ser 
1           


<210>  45
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  45

Gln Gln Gly Gln Ser Tyr Trp 
1               5           


<210>  46
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  46

Gly Tyr Thr Phe Thr Asp Tyr Val 
1               5               


<210>  47
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  47

Tyr Pro Gly Ser Gly Asn Thr 
1               5           


<210>  48
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  48

Ala Gly Gly Gly Ser Ser His Phe Asp Tyr 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  49

Gln Ser Val Asp Asn His Gly Phe Ser Phe 
1               5                   10  


<210>  50
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  50

Ala Ala Ser 
1           


<210>  51
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  51

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  52
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  52

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
            20                  25                  30          


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        35                  40                  45              


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    50                  55                  60                  


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
65                  70                  75                  80  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                85                  90                  95      


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            100                 105                 110         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
        115                 120                 125             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    130                 135                 140                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
145                 150                 155                 160 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                165                 170                 175     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            180                 185                 190         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        195                 200                 205             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
225                 230                 235                 240 


Ser Pro Gly Lys Gln Tyr Tyr Gln Leu Ser Asn Thr Gly Gln Asp Thr 
                245                 250                 255     


Ile Ser Gln Met Glu Glu Arg Leu Gly Asn Thr Ser Gln Glu Leu Gln 
            260                 265                 270         


Ser Leu Gln Val Gln Asn Ile Lys Leu Ala Gly Ser Leu Gln His Val 
        275                 280                 285             


Ala Glu Lys Leu Cys Arg Glu Leu Tyr Asn Lys Ala Gly Ala His Arg 
    290                 295                 300                 


Cys Ser Pro Cys Thr Glu Gln Trp Lys Trp His Gly Asp Asn Cys Tyr 
305                 310                 315                 320 


Gln Phe Tyr Lys Asp Ser Lys Ser Trp Glu Asp Cys Lys Tyr Phe Cys 
                325                 330                 335     


Leu Ser Glu Asn Ser Thr Met Leu Lys Ile Asn Lys Gln Glu Asp Leu 
            340                 345                 350         


Glu Phe Ala Ala Ser Gln Ser Tyr Ser Glu Phe Phe Tyr Ser Tyr Trp 
        355                 360                 365             


Thr Gly Leu Leu Arg Pro Asp Ser Gly Lys Ala Trp Leu Trp Met Asp 
    370                 375                 380                 


Gly Thr Pro Phe Thr Ser Glu Leu Phe His Ile Ile Ile Asp Val Thr 
385                 390                 395                 400 


Ser Pro Arg Ser Arg Asp Cys Val Ala Ile Leu Asn Gly Met Ile Phe 
                405                 410                 415     


Ser Lys Asp Cys Lys Glu Leu Lys Arg Cys Val Cys Glu Arg Arg Ala 
            420                 425                 430         


Gly Met Val Lys Pro Glu Ser Leu His Val Pro Pro Glu Thr Leu Gly 
        435                 440                 445             


Glu Gly Asp 
    450     


<210>  53
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  53
gacatccaga tgacacagtc tccttccagc ctgagcgcct ctgtgggcga tagggtgacc       60

atcacatgcc gggcctccga gagcatctac tcctatctgg cttggtacca gcagaagccc      120

ggcaaggccc ctaagttcct gatctataat gccaagaccc tggcttcggg agtgccatcc      180

aggttctccg gaagcggctc tggcacagac tttaccctga caatctcttc cctgcagcca      240

gaggattttg ctacctacta ttgtcagcac catttcggca cccccctgac atttggccag      300

ggcacaaagc tggagatcaa g                                                321


<210>  54
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  54
cgggcctccg agagcatcta ctcctatctg gct                                    33


<210>  55
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  55
gagagcatct actcctat                                                     18


<210>  56
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  56
aatgccaaga ccctggcttc g                                                 21


<210>  57
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  57
gagagcatct actcctat                                                     18


<210>  58
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  58
cagcaccatt tcggcacccc cctgaca                                           27


<210>  59
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  59
cagcaccatt tcggcacccc cctgaca                                           27


<210>  60
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  60
gagatcgtgc tgacccagtc cccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgtcttgcc gggctagcca gtctgtggac aaccacggct tctcctttat gaattggttc      120

cagcagaagc ccggccaggc tcctagactg ctgatctacg ctgcttccaa cagaggaaca      180

ggaatccctg ctaggttctc cggaagcgga tctggcacag actttaccct gaccatctcc      240

agcatggagc ctgaggattt cgctgtgtat tactgtcagc agtctaagga ggtgccatgg      300

acctttggcg gcggcacaaa ggtggagatc aag                                   333


<210>  61
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  61
cgggctagcc agtctgtgga caaccacggc ttctccttta tgaat                       45


<210>  62
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  62
cagtctgtgg acaaccacgg cttctccttt a                                      31


<210>  63
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  63
gctgcttcca acagaggaac a                                                 21


<210>  64
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  64
gctgcttcc                                                                9


<210>  65
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  65
cagcagtcta aggaggtgcc atggacc                                           27


<210>  66
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  66
cagcagtcta aggaggtgcc atggacc                                           27


<210>  67
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  67
gacatccaga tgacccagag cccatccagc ctgagcgcct ctgtgggcga tagggtgacc       60

atcacatgcc acgcttccca gaacatcaac gtgtggctga gctggtacca gcagaagccc      120

ggcaaggccc ctaagctgct gctgtataag gcttctaacc tgcataccgg agtgccatcc      180

cggttctccg gaagcggatc tggaacagac tttaccctga caatctcttc cctgcagccc      240

gaggacatcg ccacatacta ttgtcagcag ggccagtctt actggacctt cggcggcggc      300

acaaaggtgg agatcaag                                                    318


<210>  68
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  68
cacgcttccc agaacatcaa cgtgtggctg agc                                    33


<210>  69
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  69
cagaacatca acgtgtgg                                                     18


<210>  70
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  70
aaggcttcta acctgcatac c                                                 21


<210>  71
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  71
aaggcttct                                                                9


<210>  72
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  72
cagcagggcc agtcttactg gacc                                              24


<210>  73
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  73
cagcagggcc agtcttactg gacc                                              24


<210>  74
<211>  351
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  74
cagatccagc tggtgcagag cggctctgag ctgaagaagc caggcgcctc tgtgaaggtg       60

tcctgcaagg ctagcggcta caccttcaca aactttggca tgaattgggt gaggcaggct      120

ccaggacagg gcctggagtg gatgggctgg atcaacacca atacaggcga gcctacctac      180

gccgacgatt tcaagggccg gttcgtgttt tctctggaca cctccgtgag cacagcttat      240

ctgcagatct ccagcctgaa ggccgaggat accgctacat acttctgtgc caggggcgcc      300

cccgcttggt ttacctattg gggccagggc accacagtga cagtgtcttc c               351


<210>  75
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  75
aactttggca tgaat                                                        15


<210>  76
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  76
ggctacacct tcacaaactt tggc                                              24


<210>  77
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  77
tggatcaaca ccaatacagg cgagcctacc tacgccgacg atttcaaggg c                51


<210>  78
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  78
tggatcaaca ccaatacagg cgagcct                                           27


<210>  79
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  79
ggcgcccccg cttggtttac ctat                                              24


<210>  80
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  80
tgtgccaggg gcgcccccgc ttggtttacc tat                                    33


<210>  81
<211>  351
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  81
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggctcctc cgtgaagatg       60

tcctgcaagg cttccggcta cacctttacc gactacgtga tctcctgggt ccgacaggct      120

cctggacaag gcctggaatg gatgggcgag atctatcctg gctccggcaa cacctactac      180

aaccagaagt tccagggcag agtgaccctg accgccgaca agtctacctc caccgcttac      240

atggagctgt ccagcctgag atctgaggac accgccgtgt actactgtgc tggcggcgga      300

tcttcccact tcgattattg gggccagggc accaccgtga ccgtttcttc t               351


<210>  82
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  82
gactacgtga tctcc                                                        15


<210>  83
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  83
ggctacacct ttaccgacta cgtg                                              24


<210>  84
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  84
gagatctatc ctggctccgg caacacctac tacaaccaga agttccaggg c                51


<210>  85
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  85
tatcctggct ccggcaacac c                                                 21


<210>  86
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  86
ggcggatctt cccacttcga ttat                                              24


<210>  87
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  87
gctggcggcg gatcttccca cttcgattat                                        30


<210>  88
<211>  354
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  88
caggtgcagc tggtggagtc cggaggagga gtggtgcagc caggcaggtc cctgcggctg       60

agctgcgcca tctctggctt caccctgacc acatacggca tccactgggt gaggcaggct      120

cctggcaagg gcctggagtg ggtcgccgtc atctggagcg atgcctctac catctatgcc      180

tctagcctga agtccagatt caccatcagc aaggacaact ctaagaatac agtgtacctg      240

cagatgacca gcctgagagc cgaggataca gctatctact attgtgctcg ccatggcggc      300

tactataatt actttgacta ttggggccag ggcaccctgg tgacagtgtc cagc            354


<210>  89
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  89
acatacggca tccac                                                        15


<210>  90
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  90
ggcttcaccc tgaccacata cggc                                              24


<210>  91
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  91
gtcatctgga gcgatgcctc taccatctat gcctctagcc tgaagtcc                    48


<210>  92
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  92
tggagcgatg cctctaccat c                                                 21


<210>  93
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  93
catggcggct actataatta ctttgactat                                        30


<210>  94
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  94
cgccatggcg gctactataa ttactttgac tat                                    33


<210>  95
<211>  354
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  95
caggtgcagc tggtggagtc cggaggagga gtggtgcagc caggcaggtc cctgcggctg       60

agctgcgcca tctctggctt caccctgacc acatacggca tccactgggt gaggcaggct      120

cctggcaagg gcctggagtg ggtcgccgtc atctggagcg atgcctctac catctatgcc      180

tctagcctga agtccagatt caccatcagc aaggacaaca ccaagaatac agtgtacctg      240

cagatgacca gcctgagagc cgaggataca gctgtgtact attgtgctcg ccatggcggc      300

tactataatt actttgacta ttggggccag ggcaccctgg tgacagtgtc cagc            354


<210>  96
<211>  324
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  96
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210>  97
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  97

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  98
<211>  993
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  98
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacgcc      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  99
<211>  984
<212>  DNA
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  99
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctccgggtaa atga                                             984


<210>  100
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  100

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  101
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  101

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  102
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Phe Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  103
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Gly Ser Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  104
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic sequence

<400>  104

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asn His 
            20                  25                  30          


Gly Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Gly Thr Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Met Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


