                    SEQUENCE LISTING

<110>  Gadeta B.V.

<120>  Delta T-cell or Gamma T-cell receptor chains or parts 
       thereof that mediate an anti-tumour or anti-infective response 

<130>  P6100857PCT

<150>  EP 21178061.4
<151>  2021-06-07

<160>  165

<210>  1
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD CDR3 clone 1

<400>  1
Cys Ala Phe Ile Val Tyr Asp Phe Leu Gly Glu Leu Gly Glu Asp 
1               5                   10                  15  

Thr Asp Lys Leu Ile Phe 
                20      

<210>  2
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRD codon optimised clone 1

<400>  2
atgatcctga ccgtgggctt cagcttcctg ttcttctacc ggggcaccct            50
gtgcgacaaa gtgacacagt ctagccccga tcagacagtg gcctctggat            100
ctgaagtggt gctgctgtgc acctacgaca ccgtgtacag caaccccgac            150
ctgttctggt acagaatcag acccgactac agcttccagt tcgtgttcta            200
cggcgacaac agcagaagcg agggcgccga tttcacccag ggcagatttt            250
ccgtgaagca catcctgaca cagaaagcct tccacctggt catcagccct            300
gtgcggacag aggatagcgc cacctactat tgcgccttta tcgtgtacga            350
cttcctgggc gagctgggcg aagataccga caagctgatc ttcggcaagg            400
gcacccgggt gaccgtggag cccagaagcc agccccacac caagcccagc            450
gtgttcgtga tgaagaacgg caccaacgtg gcctgcctgg tgaaagagtt            500
ctaccccaag gacatccgga tcaacctggt gtccagcaag aagatcaccg            550
agttcgaccc cgccatcgtg atcagcccca gcggcaagta caacgccgtg            600
aagctgggca agtacgagga cagcaacagc gtgacctgca gcgtgcagca            650
cgacaacaag accgtgcaca gcaccgactt cgaggtgaaa accgactcca            700
ccgaccacgt gaagcccaaa gagaccgaga acaccaagca gcccagcaag            750
agctgccaca agcccaaggc catcgtgcac accgagaagg tgaacatgat            800
gagcctgacc gtgctgggcc tgcggatgct gttcgccaag acagtggccg            850
tgaacttcct gctgaccgcc aagctgttct tcctg                            885

<210>  3
<211>  295
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD full length clone 1

<400>  3
Met Ile Leu Thr Val Gly Phe Ser Phe Leu Phe Phe Tyr Arg Gly 
1               5                   10                  15  

Thr Leu Cys Asp Lys Val Thr Gln Ser Ser Pro Asp Gln Thr Val 
                20                  25                  30  

Ala Ser Gly Ser Glu Val Val Leu Leu Cys Thr Tyr Asp Thr Val 
                35                  40                  45  

Tyr Ser Asn Pro Asp Leu Phe Trp Tyr Arg Ile Arg Pro Asp Tyr 
                50                  55                  60  

Ser Phe Gln Phe Val Phe Tyr Gly Asp Asn Ser Arg Ser Glu Gly 
                65                  70                  75  

Ala Asp Phe Thr Gln Gly Arg Phe Ser Val Lys His Ile Leu Thr 
                80                  85                  90  

Gln Lys Ala Phe His Leu Val Ile Ser Pro Val Arg Thr Glu Asp 
                95                  100                 105 

Ser Ala Thr Tyr Tyr Cys Ala Phe Ile Val Tyr Asp Phe Leu Gly 
                110                 115                 120 

Glu Leu Gly Glu Asp Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr 
                125                 130                 135 

Arg Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser 
                140                 145                 150 

Val Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys 
                155                 160                 165 

Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys 
                170                 175                 180 

Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly 
                185                 190                 195 

Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser 
                200                 205                 210 

Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr 
                215                 220                 225 

Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys 
                230                 235                 240 

Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro 
                245                 250                 255 

Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
                260                 265                 270 

Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn 
                275                 280                 285 

Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu 
                290                 295 

<210>  4
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG CDR3 clone 1

<400>  4
Cys Ala Thr Trp Asp Ser Lys Pro His Tyr Tyr Lys Lys Leu Phe 
1               5                   10                  15  




<210>  5
<211>  975
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 1

<400>  5
atgagatggg ctctgctggt gctgctggcc tttctgtctc ctgccagcca            50
gaagtccagc aacctggaag gcagaacaaa gagcgtgacc agacagaccg            100
gaagcagcgc cgagatcacc tgtgatctga ccgtgaccaa caccttctac            150
atccactggt atctgcacca agagggcaaa gcccctcagc ggctgctgta            200
ctacgatgtg tctaccgcca gggacgtgct ggaatctgga ctgagccctg            250
gcaagtacta cacccacaca cctcggcggt ggtcctggat tctgagactg            300
cagaacctga tcgagaacga ctccggcgtg tactactgtg ccacctggga            350
tagcaagccc cactactaca agaagctgtt cggcagcggc accacactgg            400
tggttacaga caagcagctg gacgccgacg tgtcccccaa gcctaccatc            450
ttcctgccct caattgctga gacaaagctg cagaaggccg gcacctacct            500
gtgcctgctg gaaaagttct tcccagacat catcaagatc cactggcaag            550
aaaagaagtc caacaccatc ctgggcagcc aagaaggcaa caccatgaag            600
accaacgaca cctacatgaa gttcagctgg ctgaccgtgc ccgaggagtc            650
cctggacaaa gaacaccggt gcatcgtgcg gcacgagaac aacaagaacg            700
gcatcgacca agaaatcatc ttcccaccca tcaagaccga cgtgacaaca            750
gtggacccca agtacaacta cagcaaggac gccaacgacg tgatcacaat            800
ggaccccaag gacaactgga gcaaggacgc caacgatacc ctgctgctgc            850
agctgacaaa caccagcgcc tactacatgt acttgttgct gctgctgaag            900
tccgtggtgt acttcgccat catcacatgc tgcctgctgg gccggaccgc            950
cttctgctgc aacggcgaga agtcc                                       975

<210>  6
<211>  325
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG full length clone 1

<400>  6
Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Ser Lys Pro 
                110                 115                 120 

His Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val 
                125                 130                 135 

Thr Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile 
                140                 145                 150 

Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr 
                155                 160                 165 

Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile 
                170                 175                 180 

His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu 
                185                 190                 195 

Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp 
                200                 205                 210 

Leu Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile 
                215                 220                 225 

Val Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile 
                230                 235                 240 

Phe Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr 
                245                 250                 255 

Asn Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys 
                260                 265                 270 

Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu 
                275                 280                 285 

Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys 
                290                 295                 300 

Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Gly Arg 
                305                 310                 315 

Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                320                 325 

<210>  7
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD CDR3 clone 2

<400>  7
Cys Ala Cys Gly Leu Pro Arg Ser Leu Ala Asp Lys Leu Ile Phe 
1               5                   10                  15  




<210>  8
<211>  867
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRD codon optimised clone 2

<400>  8
atgatcctga ccgtgggctt cagcttcctg ttcttctacc ggggcaccct            50
gtgcgacaaa gtgacacagt ctagccccga tcagacagtg gcctctggat            100
ctgaagtggt gctgctgtgc acctacgaca ccgtgtacag caaccccgac            150
ctgttctggt acagaatcag acccgactac agcttccagt tcgtgttcta            200
cggcgacaac agcagaagcg agggcgccga tttcacccag ggcagatttt            250
ccgtgaagca catcctgaca cagaaagcct tccacctggt catcagccct            300
gtgcggacag aggatagcgc cacctactat tgtgcttgtg gcctgcctag            350
aagcctggcc gacaagctga tcttcggcaa gggcacccgg gtgaccgtgg            400
agcccagaag ccagccccac accaagccca gcgtgttcgt gatgaagaac            450
ggcaccaacg tggcctgcct ggtgaaagag ttctacccca aggacatccg            500
gatcaacctg gtgtccagca agaagatcac cgagttcgac cccgccatcg            550
tgatcagccc cagcggcaag tacaacgccg tgaagctggg caagtacgag            600
gacagcaaca gcgtgacctg cagcgtgcag cacgacaaca agaccgtgca            650
cagcaccgac ttcgaggtga aaaccgactc caccgaccac gtgaagccca            700
aagagaccga gaacaccaag cagcccagca agagctgcca caagcccaag            750
gccatcgtgc acaccgagaa ggtgaacatg atgagcctga ccgtgctggg            800
cctgcggatg ctgttcgcca agacagtggc cgtgaacttc ctgctgaccg            850
ccaagctgtt cttcctg                                                867

<210>  9
<211>  289
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD full length clone 2

<400>  9
Met Ile Leu Thr Val Gly Phe Ser Phe Leu Phe Phe Tyr Arg Gly 
1               5                   10                  15  

Thr Leu Cys Asp Lys Val Thr Gln Ser Ser Pro Asp Gln Thr Val 
                20                  25                  30  

Ala Ser Gly Ser Glu Val Val Leu Leu Cys Thr Tyr Asp Thr Val 
                35                  40                  45  

Tyr Ser Asn Pro Asp Leu Phe Trp Tyr Arg Ile Arg Pro Asp Tyr 
                50                  55                  60  

Ser Phe Gln Phe Val Phe Tyr Gly Asp Asn Ser Arg Ser Glu Gly 
                65                  70                  75  

Ala Asp Phe Thr Gln Gly Arg Phe Ser Val Lys His Ile Leu Thr 
                80                  85                  90  

Gln Lys Ala Phe His Leu Val Ile Ser Pro Val Arg Thr Glu Asp 
                95                  100                 105 

Ser Ala Thr Tyr Tyr Cys Ala Cys Gly Leu Pro Arg Ser Leu Ala 
                110                 115                 120 

Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro 
                125                 130                 135 

Arg Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn 
                140                 145                 150 

Gly Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp 
                155                 160                 165 

Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp 
                170                 175                 180 

Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys 
                185                 190                 195 

Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser Val Gln 
                200                 205                 210 

His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val Lys Thr 
                215                 220                 225 

Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys 
                230                 235                 240 

Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val His Thr 
                245                 250                 255 

Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg Met 
                260                 265                 270 

Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys 
                275                 280                 285 

Leu Phe Phe Leu 
                

<210>  10
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG CDR3 clone 2

<400>  10
Cys Ala Thr Trp Asp Leu His Lys Lys Leu Phe 
1               5                   10      

<210>  11
<211>  963
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 2

<400>  11
atggagtggg ccctggccgt gctgctggcc tttctgagcc ctgccagcca            50
gaagtccagc aacctggaag gccggaccaa gagcgtgatc cggcagacag            100
gcagcagcgc cgagatcacc tgtgacctgg ccgagggcag caccggctac            150
atccactggt atctgcacca agaaggcaag gccccccagc ggctgctgta            200
ctacgacagc tacaccagct ccgtggtgct ggaaagcggc atcagccccg            250
ggaagtacga cacctacggc agcacccgga agaacctgcg gatgatcctg            300
cggaacctga tcgagaacga cagcggcgtg tactactgtg ccacatggga            350
cctgcacaag aagctgttcg gcagcggcac aaccctggtg gttacagaca            400
agcagctgga cgccgacgtg tcccccaagc ctaccatctt cctgccctca            450
attgctgaga caaagctgca gaaggccggc acctacctgt gcctgctgga            500
aaagttcttc ccagacatca tcaagatcca ctggcaagaa aagaagtcca            550
acaccatcct gggcagccaa gaaggcaaca ccatgaagac caacgacacc            600
tacatgaagt tcagctggct gaccgtgccc gaggagtccc tggacaaaga            650
acaccggtgc atcgtgcggc acgagaacaa caagaacggc atcgaccaag            700
aaatcatctt cccacccatc aagaccgacg tgacaacagt ggaccccaag            750
tacaactaca gcaaggacgc caacgacgtg atcacaatgg accccaagga            800
caactggagc aaggacgcca acgataccct gctgctgcag ctgacaaaca            850
ccagcgccta ctacatgtac ttgttgctgc tgctgaagtc cgtggtgtac            900
ttcgccatca tcacatgctg cctgctgggc cggaccgcct tctgctgcaa            950
cggcgagaag tcc                                                    963

<210>  12
<211>  321
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG full length clone 2

<400>  12
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Leu His Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys Gln 
                125                 130                 135 

Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
                140                 145                 150 

Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu 
                155                 160                 165 

Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu 
                170                 175                 180 

Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met 
                185                 190                 195 

Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro 
                200                 205                 210 

Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu 
                215                 220                 225 

Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro Ile 
                230                 235                 240 

Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn Tyr Ser Lys 
                245                 250                 255 

Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp Asn Trp Ser 
                260                 265                 270 

Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser 
                275                 280                 285 

Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr 
                290                 295                 300 

Phe Ala Ile Ile Thr Cys Cys Leu Leu Gly Arg Thr Ala Phe Cys 
                305                 310                 315 

Cys Asn Gly Glu Lys Ser 
                320     

<210>  13
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD CDR3 clone 3

<400>  13
Cys Ala Leu Gly Glu Phe Pro Tyr Trp Gly Ile Pro Asp Lys Leu 
1               5                   10                  15  

Ile Phe 
        

<210>  14
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRD codon optimised clone 3

<400>  14
atggtgttca gcagcctgct gtgcgtgttc gtggccttca gctacagcgg            50
cagcagcgtg gcccagaaag tgacccaggc ccagagcagc gtgtccatgc            100
ctgtgcggaa ggccgtgacc ctgaactgcc tgtacgagac aagctggtgg            150
tcctactaca tcttctggta caagcagctg cccagcaaag agatgatctt            200
cctgatccgg cagggcagcg acgagcagaa cgccaagagc ggccggtaca            250
gcgtgaactt caagaaagcc gccaagtccg tggccctgac catcagcgcc            300
ctgcagctgg aagatagcgc caagtatttc tgtgccctgg gcgagtttcc            350
ttattggggc atccccgaca agctgatctt cggcaagggc acccgggtga            400
ccgtggagcc cagaagccag ccccacacca agcccagcgt gttcgtgatg            450
aagaacggca ccaacgtggc ctgcctggtg aaagagttct accccaagga            500
catccggatc aacctggtgt ccagcaagaa gatcaccgag ttcgaccccg            550
ccatcgtgat cagccccagc ggcaagtaca acgccgtgaa gctgggcaag            600
tacgaggaca gcaacagcgt gacctgcagc gtgcagcacg acaacaagac            650
cgtgcacagc accgacttcg aggtgaaaac cgactccacc gaccacgtga            700
agcccaaaga gaccgagaac accaagcagc ccagcaagag ctgccacaag            750
cccaaggcca tcgtgcacac cgagaaggtg aacatgatga gcctgaccgt            800
gctgggcctg cggatgctgt tcgccaagac agtggccgtg aacttcctgc            850
tgaccgccaa gctgttcttc ctg                                         873

<210>  15
<211>  291
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD full length clone 3

<400>  15
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Phe Pro Tyr Trp Gly 
                110                 115                 120 

Ile Pro Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val 
                125                 130                 135 

Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met 
                140                 145                 150 

Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro 
                155                 160                 165 

Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu 
                170                 175                 180 

Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala 
                185                 190                 195 

Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val Thr Cys Ser 
                200                 205                 210 

Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp Phe Glu Val 
                215                 220                 225 

Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu Asn 
                230                 235                 240 

Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val 
                245                 250                 255 

His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu 
                260                 265                 270 

Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr 
                275                 280                 285 

Ala Lys Leu Phe Phe Leu 
                290     

<210>  16
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG CDR3 clone 3

<400>  16
Cys Ala Thr Trp Asp Gly Tyr Tyr Lys Lys Leu Phe 
1               5                   10          

<210>  17
<211>  915
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 3

<400>  17
atgagatggg ctctgctggt gctgctggcc tttctgtctc ctgccagcca            50
gaagtccagc aacctggaag gcagaacaaa gagcgtgacc agacagaccg            100
gaagcagcgc cgagatcacc tgtgatctga ccgtgaccaa caccttctac            150
atccactggt atctgcacca agagggcaaa gcccctcagc ggctgctgta            200
ctacgatgtg tctaccgcca gggacgtgct ggaatctgga ctgagccctg            250
gcaagtacta cacccacaca cctcggcggt ggtcctggat tctgagactg            300
cagaacctga tcgagaacga ctccggcgtg tactactgtg ctacctggga            350
cggctactac aagaagctgt tcggcagcgg caccacactg gtggttacag            400
acaagcagct ggacgccgac gtgagcccca agcctaccat cttcctgccc            450
agcatcgccg agaccaagct gcagaaggcc ggcacctacc tgtgcctgct            500
ggaaaagttc ttccccgacg tgatcaagat ccactgggag gaaaagaaga            550
gcaacaccat cctgggcagc caggaaggca ataccatgaa aaccaacgac            600
acctacatga agttcagctg gctgaccgtg cccgagaaga gcctggacaa            650
agagcacaga tgcatcgtcc ggcacgagaa caacaagaac ggcgtggacc            700
aggaaatcat cttccccccc atcaagaccg atgtgatcac aatggacccc            750
aaggacaact gcagcaagga cgccaacgat accctgctgc tgcagctgac            800
caacaccagc gcctactaca tgtatctcct gctgctgctg aagagcgtgg            850
tgtacttcgc catcatcacc tgctgtctgc tgcggcggac cgccttctgc            900
tgcaacggcg agaag                                                  915

<210>  18
<211>  305
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG full length clone 3

<400>  18
Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Tyr Tyr 
                110                 115                 120 

Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys 
                125                 130                 135 

Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro 
                140                 145                 150 

Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
                155                 160                 165 

Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu 
                170                 175                 180 

Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr 
                185                 190                 195 

Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val 
                200                 205                 210 

Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His 
                215                 220                 225 

Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro 
                230                 235                 240 

Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser 
                245                 250                 255 

Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser 
                260                 265                 270 

Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr 
                275                 280                 285 

Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys 
                290                 295                 300 

Cys Asn Gly Glu Lys 
                305 

<210>  19
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRD CDR3 clone 4

<400>  19
Cys Ala Leu Gly Gly Leu Gly Trp Gly Tyr Ala Gly Asp Glu Gly 
1               5                   10                  15  

Gly Gly Lys Leu Thr Asp Lys Leu Ile Phe 
                20                  25  

<210>  20
<211>  897
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRD codon optimised clone 4

<400>  20
atggtgttca gcagcctgct gtgcgtgttc gtggccttca gctacagcgg            50
cagcagcgtg gcccagaaag tgacccaggc ccagagcagc gtgtccatgc            100
ctgtgcggaa ggccgtgacc ctgaactgcc tgtacgagac aagctggtgg            150
tcctactaca tcttctggta caagcagctg cccagcaaag agatgatctt            200
cctgatccgg cagggcagcg acgagcagaa cgccaagagc ggccggtaca            250
gcgtgaactt caagaaagcc gccaagtccg tggccctgac catcagcgcc            300
ctgcagctgg aagatagcgc caagtatttc tgtgcccttg gaggactcgg            350
atggggatat gctggcgacg aaggcggagg caagctgacc gataagctga            400
tcttcggcaa gggcacccgg gtgaccgtgg agcccagaag ccagccccac            450
accaagccca gcgtgttcgt gatgaagaac ggcaccaacg tggcctgcct            500
ggtgaaagag ttctacccca aggacatccg gatcaacctg gtgtccagca            550
agaagatcac cgagttcgac cccgccatcg tgatcagccc cagcggcaag            600
tacaacgccg tgaagctggg caagtacgag gacagcaaca gcgtgacctg            650
cagcgtgcag cacgacaaca agaccgtgca cagcaccgac ttcgaggtga            700
aaaccgactc caccgaccac gtgaagccca aagagaccga gaacaccaag            750
cagcccagca agagctgcca caagcccaag gccatcgtgc acaccgagaa            800
ggtgaacatg atgagcctga ccgtgctggg cctgcggatg ctgttcgcca            850
agacagtggc cgtgaacttc ctgctgaccg ccaagctgtt cttcctg               897

<210>  21
<211>  299
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRD full length clone 4

<400>  21
Met Val Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr 
1               5                   10                  15  

Ser Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser 
                20                  25                  30  

Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr 
                35                  40                  45  

Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu 
                50                  55                  60  

Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu 
                65                  70                  75  

Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala 
                80                  85                  90  

Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln Leu Glu Asp 
                95                  100                 105 

Ser Ala Lys Tyr Phe Cys Ala Leu Gly Gly Leu Gly Trp Gly Tyr 
                110                 115                 120 

Ala Gly Asp Glu Gly Gly Gly Lys Leu Thr Asp Lys Leu Ile Phe 
                125                 130                 135 

Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His 
                140                 145                 150 

Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala 
                155                 160                 165 

Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu 
                170                 175                 180 

Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile 
                185                 190                 195 

Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu 
                200                 205                 210 

Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr 
                215                 220                 225 

Val His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His 
                230                 235                 240 

Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser 
                245                 250                 255 

Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met 
                260                 265                 270 

Met Ser Leu Thr Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr 
                275                 280                 285 

Val Ala Val Asn Phe Leu Leu Thr Ala Lys Leu Phe Phe Leu 
                290                 295                 

<210>  22
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG CDR3 clone 4

<400>  22
Cys Ala Leu Trp Glu Val His Pro Asn Tyr Lys Lys Leu Phe 
1               5                   10                  

<210>  23
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 4

<400>  23
atggtgtccc tgctgcacgc cagcaccctg gccgtgctgg gcgccctgtg            50
cgtgtatggc gccggacacc tggaacagcc ccagatcagc agcaccaaga            100
ccctgagcaa gaccgccagg ctggaatgcg tggtgtccgg catcaccatc            150
agcgccacct ccgtgtactg gtacagagag agacccggcg aggtcatcca            200
gttcctggtg tccatcagct acgacggcac cgtgcggaaa gagagcggca            250
tccccagcgg caagttcgag gtggacagaa tccccgagac cagcacctcc            300
accctgacca tccacaacgt ggagaagcag gacatcgcca cctactactg            350
tgctctgtgg gaagtgcacc ccaactacaa gaagctgttc ggcagcggca            400
ccacactggt ggttacagac aagcagctgg acgccgacgt gtcccccaag            450
cctaccatct tcctgccctc aattgctgag acaaagctgc agaaggccgg            500
cacctacctg tgcctgctgg aaaagttctt cccagacatc atcaagatcc            550
actggcaaga aaagaagtcc aacaccatcc tgggcagcca agaaggcaac            600
accatgaaga ccaacgacac ctacatgaag ttcagctggc tgaccgtgcc            650
cgaggagtcc ctggacaaag aacaccggtg catcgtgcgg cacgagaaca            700
acaagaacgg catcgaccaa gaaatcatct tcccacccat caagaccgac            750
gtgacaacag tggaccccaa gtacaactac agcaaggacg ccaacgacgt            800
gatcacaatg gaccccaagg acaactggag caaggacgcc aacgataccc            850
tgctgctgca gctgacaaac accagcgcct actacatgta cttgttgctg            900
ctgctgaagt ccgtggtgta cttcgccatc atcacatgct gcctgctggg            950
ccggaccgcc ttctgctgca acggcgagaa gtcc                             984

<210>  24
<211>  328
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG full length clone 4

<400>  24
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala 
1               5                   10                  15  

Leu Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser 
                20                  25                  30  

Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val 
                35                  40                  45  

Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
                50                  55                  60  

Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp 
                65                  70                  75  

Gly Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu 
                80                  85                  90  

Val Asp Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His 
                95                  100                 105 

Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp 
                110                 115                 120 

Glu Val His Pro Asn Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr 
                125                 130                 135 

Leu Val Val Thr Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys 
                140                 145                 150 

Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys 
                155                 160                 165 

Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile 
                170                 175                 180 

Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly 
                185                 190                 195 

Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys 
                200                 205                 210 

Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His 
                215                 220                 225 

Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln 
                230                 235                 240 

Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp 
                245                 250                 255 

Pro Lys Tyr Asn Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met 
                260                 265                 270 

Asp Pro Lys Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu 
                275                 280                 285 

Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu 
                290                 295                 300 

Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu 
                305                 310                 315 

Leu Gly Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                320                 325             

<210>  25
<211>  6539
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pLenti 6.3

<400>  25
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga            50
gttagcaaca tgccttacaa ggagagaaaa agcaccgtgc atgccgattg            100
gtggaagtaa ggtggtacga tcgtgcctta ttaggaaggc aacagacggg            150
tctgacatgg attggacgaa ccactgaatt gccgcattgc agagatattg            200
tatttaagtg cctagctcga tacataaacg ggtctctctg gttagaccag            250
atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc            300
tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt            350
gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa            400
atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca            450
gaggagctct ctcgacgcag gactcggctt gctgaagcgc gcacggcaag            500
aggcgagggg cggcgactgg tgagtacgcc aaaaattttg actagcggag            550
gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga            600
attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa            650
atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg            700
cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg            750
ggacagctac aaccatccct tcagacagga tcagaagaac ttagatcatt            800
atataataca gtagcaaccc tctattgtgt gcatcaaagg atagagataa            850
aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt            900
aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag            950
atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa            1000
attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca            1050
gagagaaaaa agagcagtgg gaataggagc tttgttcctt gggttcttgg            1100
gagcagcagg aagcactatg ggcgcagcgt caatgacgct gacggtacag            1150
gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag            1200
ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca            1250
agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa            1300
cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc            1350
tgtgccttgg aatgctagtt ggagtaataa atctctggaa cagatttgga            1400
atcacacgac ctggatggag tgggacagag aaattaacaa ttacacaagc            1450
ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga            1500
acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta            1550
acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga            1600
ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag            1650
agttaggcag ggatattcac cattatcgtt tcagacccac ctcccaaccc            1700
cgaggggacc cgacaggccc gaaggaatag aagaagaagg tggagagaga            1750
gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcggtt            1800
aacttttaaa agaaaagggg ggattggggg gtacagtgca ggggaaagaa            1850
tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa            1900
attacaaaaa ttcaaaattt tatcgatgca tgctgaaaga ccccacctgt            1950
aggtttggca agctagctta agtaacgcca ttttgcaagg catggaaaat            2000
acataactga gaatagagaa gttcagatca aggttaggaa cagagagaca            2050
gcagaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg            2100
ctcagggcca agaacagatg gtccccagat gcggtcccgc cctcagcagt            2150
ttctagagaa ccatcagatg tttccagggt gccccaagga cctgaaaatg            2200
accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt            2250
cgcgcgtttc tgctccccga gctcaataaa agagcccaca acccctcact            2300
agcggcccta atacgactca ctatagcccg gctcgaggct aggcgcgaat            2350
tcgccacccg gatccacgcg taccggttag taatgatcga caatcaacct            2400
ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc            2450
tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta            2500
ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg            2550
ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt            2600
gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca            2650
cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg            2700
gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct            2750
gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc            2800
catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc            2850
tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct            2900
gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga            2950
gtcggatctc cctttgggcc gcctccccgc ctggcgatgg tacctttaag            3000
accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa            3050
aggggggact ggaagggcta attcactccc aacgaagaca agatctgctt            3100
tttgcttgta ctgggtctct ctggttagac cagatctgag cctgggagct            3150
ctctggctaa ctagggaacc cactgcttaa gcctcaataa agcttgcctt            3200
gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag            3250
agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagtagtag            3300
ttcatgtcat cttattattc agtatttata acttgcaaag aaatgaatat            3350
cagagagtga gaggaacttg tttattgcag cttataatgg ttacaaataa            3400
agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc            3450
tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctggctct            3500
agctatcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt            3550
ccgcccattc tccgccccat ggctgactaa ttttttttat ttatgcagag            3600
gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt            3650
ttttggaggc ctagggacgt acccaattcg ccctatagtg agtcgtatta            3700
cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg            3750
gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg            3800
cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag            3850
cctgaatggc gaatgggacg cgccctgtag cggcgcatta agcgcggcgg            3900
gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg            3950
cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt            4000
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg            4050
ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt            4100
agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc            4150
cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc            4200
ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc            4250
tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa            4300
caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg            4350
cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc            4400
tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag            4450
agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc            4500
attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag            4550
atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc            4600
aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat            4650
gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg            4700
acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac            4750
ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac            4800
agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg            4850
ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt            4900
ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga            4950
gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag            5000
caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta            5050
gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg            5100
accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat            5150
ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca            5200
gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc            5250
aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga            5300
ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt            5350
gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt            5400
tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag            5450
cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt            5500
ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt            5550
ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg            5600
gcttcagcag agcgcagata ccaaatactg ttcttctagt gtagccgtag            5650
ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct            5700
gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta            5750
ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc            5800
tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac            5850
cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg            5900
aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga            5950
gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc            6000
tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt            6050
caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg            6100
ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc            6150
ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg            6200
ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg            6250
gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca            6300
ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc            6350
gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta            6400
cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca            6450
atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta            6500
accctcacta aagggaacaa aagctggagc tgcaagctt                        6539

<210>  26
<211>  885
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRD full length wild type clone 1

<400>  26
atgattctta ctgtgggctt tagctttttg tttttctaca ggggcacgct            50
gtgtgacaaa gtaacccaga gttccccgga ccagacggtg gcgagtggca            100
gtgaggtggt actgctctgc acttacgaca ctgtatattc aaatccagat            150
ttattctggt accggataag gccagattat tcctttcagt ttgtctttta            200
tggggataac agcagatcag aaggtgcaga ttttactcaa ggacggtttt            250
ctgtgaaaca cattctgacc cagaaagcct ttcacttggt gatctctcca            300
gtaaggactg aagacagtgc cacttactac tgtgccttta tcgtttatga            350
cttcctagga gaactggggg aagacaccga taaactcatc tttggaaaag            400
gaacccgtgt gactgtggaa ccaagaagtc agcctcatac caaaccatcc            450
gtttttgtca tgaaaaatgg aacaaatgtc gcttgtctgg tgaaggaatt            500
ctaccccaag gatataagaa taaatctcgt gtcatccaag aagataacag            550
agtttgatcc tgctattgtc atctctccca gtgggaagta caatgctgtc            600
aagcttggta aatatgaaga ttcaaattca gtgacatgtt cagttcaaca            650
cgacaataaa actgtgcact ccactgactt tgaagtgaag acagattcta            700
cagatcacgt aaaaccaaag gaaactgaaa acacaaagca accttcaaag            750
agctgccata aacccaaagc catagttcat accgagaagg tgaacatgat            800
gtccctcaca gtgcttgggc tacgaatgct gtttgcaaag actgttgccg            850
tcaattttct cttgactgcc aagttatttt tcttg                            885

<210>  27
<211>  975
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRG full length wild type clone 1

<400>  27
atgcggtggg ccctactggt gcttctagct ttcctgtctc ctgccagtca            50
gaaatcttcc aacttggaag ggagaacgaa gtcagtcacc aggcagactg            100
ggtcatctgc tgaaatcact tgcgatctta ctgtaacaaa taccttctac            150
atccactggt acctacacca ggaggggaag gccccacagc gtcttctgta            200
ctatgacgtc tccaccgcaa gggatgtgtt ggaatcagga ctcagtccag            250
gaaagtatta tactcataca cccaggaggt ggagctggat attgagactg            300
caaaatctaa ttgaaaatga ttctggggtc tattactgtg ccacctggga            350
cagtaaacct cattattata agaaactctt tggcagtgga acaacacttg            400
ttgtcacaga taaacaactt gatgcagatg tttcccccaa gcccactatt            450
tttcttcctt cgattgctga aacaaaactc cagaaggctg gaacatacct            500
ttgtcttctt gagaaatttt tcccagatat tattaagata cattggcaag            550
aaaagaagag caacacgatt ctgggatccc aggaggggaa caccatgaag            600
actaacgaca catacatgaa atttagctgg ttaacggtgc cagaagagtc            650
actggacaaa gaacacagat gtatcgtcag acatgagaat aataaaaacg            700
gaattgatca agaaattatc tttcctccaa taaagacaga tgtcaccaca            750
gtggatccca aatacaatta ttcaaaagat gcaaatgatg tcatcacaat            800
ggatcccaaa gacaattggt caaaagatgc aaatgataca ctactgctgc            850
agctcacaaa cacctctgca tattacatgt acctcctcct gctcctcaag            900
agtgtggtct attttgccat catcacctgc tgtctgcttg gaagaacggc            950
tttctgctgc aatggagaga aatca                                       975

<210>  28
<211>  867
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRD full length wild type clone 2

<400>  28
atgattctta ctgtgggctt tagctttttg tttttctaca ggggcacgct            50
gtgtgacaaa gtaacccaga gttccccgga ccagacggtg gcgagtggca            100
gtgaggtggt actgctctgc acttacgaca ctgtatattc aaatccagat            150
ttattctggt accggataag gccagattat tcctttcagt ttgtctttta            200
tggggataac agcagatcag aaggtgcaga ttttactcaa ggacggtttt            250
ctgtgaaaca cattctgacc cagaaagcct ttcacttggt gatctctcca            300
gtaaggactg aagacagtgc cacttactac tgtgcctgtg gccttccccg            350
ttctctggcc gataaactca tctttggaaa aggaacccgt gtgactgtgg            400
aaccaagaag tcagcctcat accaaaccat ccgtttttgt catgaaaaat            450
ggaacaaatg tcgcttgtct ggtgaaggaa ttctacccca aggatataag            500
aataaatctc gtgtcatcca agaagataac agagtttgat cctgctattg            550
tcatctctcc cagtgggaag tacaatgctg tcaagcttgg taaatatgaa            600
gattcaaatt cagtgacatg ttcagttcaa cacgacaata aaactgtgca            650
ctccactgac tttgaagtga agacagattc tacagatcac gtaaaaccaa            700
aggaaactga aaacacaaag caaccttcaa agagctgcca taaacccaaa            750
gccatagttc ataccgagaa ggtgaacatg atgtccctca cagtgcttgg            800
gctacgaatg ctgtttgcaa agactgttgc cgtcaatttt ctcttgactg            850
ccaagttatt tttcttg                                                867

<210>  29
<211>  963
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRG full length wild type clone 2

<400>  29
atgcagtggg ccctagcggt gcttctagct ttcctgtctc ctgccagtca            50
gaaatcttcc aacttggaag ggagaacgaa gtcagtcatc aggcagactg            100
ggtcatctgc tgaaatcact tgtgatcttg ctgaaggaag taccggctac            150
atccactggt acctacacca ggaggggaag gccccacagc gtcttctgta            200
ctatgactcc tacacctcca gcgttgtgtt ggaatcagga atcagcccag            250
ggaagtatga tacttacgga agcacaagga agaacttgag aatgatactg            300
cgaaatctta ttgaaaatga ctctggagtc tattactgtg ccacctggga            350
tctgcataag aaactctttg gcagtggaac aacacttgtt gtcacagata            400
aacaacttga tgcagatgtt tcccccaagc ccactatttt tcttccttcg            450
attgctgaaa caaaactcca gaaggctgga acataccttt gtcttcttga            500
gaaatttttc ccagatatta ttaagataca ttggcaagaa aagaagagca            550
acacgattct gggatcccag gaggggaaca ccatgaagac taacgacaca            600
tacatgaaat ttagctggtt aacggtgcca gaagagtcac tggacaaaga            650
acacagatgt atcgtcagac atgagaataa taaaaacgga attgatcaag            700
aaattatctt tcctccaata aagacagatg tcaccacagt ggatcccaaa            750
tacaattatt caaaggatgc aaatgatgtc atcacaatgg atcccaaaga            800
caattggtca aaagatgcaa atgatacact actgctgcag ctcacaaaca            850
cctctgcata ttacatgtac ctcctcctgc tcctcaagag tgtggtctat            900
tttgccatca tcacctgctg tctgcttgga agaacggctt tctgctgcaa            950
tggagagaaa tca                                                    963

<210>  30
<211>  873
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRD full length wild type clone 3

<400>  30
atgctgttct ccagcctgct gtgtgtattt gtggccttca gctactctgg            50
atcaagtgtg gcccagaagg ttactcaagc ccagtcatca gtatccatgc            100
cagtgaggaa agcagtcacc ctgaactgcc tgtatgaaac aagttggtgg            150
tcatattata ttttttggta caagcaactt cccagcaaag agatgatttt            200
ccttattcgc cagggttctg atgaacagaa tgcaaaaagt ggtcgctatt            250
ctgtcaactt caagaaagca gcgaaatccg tcgccttaac catttcagcc            300
ttacagctag aagattcagc aaagtacttt tgtgctcttg gggaattccc            350
ctactggggg atccccgata aactcatctt tggaaaagga acccgtgtga            400
ctgtggaacc aagaagtcag cctcatacca aaccatccgt ttttgtcatg            450
aaaaatggaa caaatgtcgc ttgtctggtg aaggaattct accccaagga            500
tataagaata aatctcgtgt catccaagaa gataacagag tttgatcctg            550
ctattgtcat ctctcccagt gggaagtaca atgctgtcaa gcttggtaaa            600
tatgaagatt caaattcagt gacatgttca gttcaacacg acaataaaac            650
tgtgcactcc actgactttg aagtgaagac agattctaca gatcacgtaa            700
aaccaaagga aactgaaaac acaaagcaac cttcaaagag ctgccataaa            750
cccaaagcca tagttcatac cgagaaggtg aacatgatgt ccctcacagt            800
gcttgggcta cgaatgctgt ttgcaaagac tgttgccgtc aattttctct            850
tgactgccaa gttatttttc ttg                                         873

<210>  31
<211>  915
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRG full length wild type clone 3

<400>  31
atgcggtggg ccctactggt gcttctagct ttcctgtctc ctgccagtca            50
gaaatcttcc aacttggaag ggagaacgaa gtcagtcacc aggcagactg            100
ggtcatctgc tgaaatcact tgcgatctta ctgtaacaaa taccttctac            150
atccactggt acctacacca ggaggggaag gccccacagc gtcttctgta            200
ctatgacgtc tccaccgcaa gggatgtgtt ggaatcagga ctcagtccag            250
gaaagtatta tactcataca cccaggaggt ggagctggat attgagactg            300
caaaatctaa ttgaaaatga ttctggggtc tattactgtg ccacctggga            350
cggctattat aagaaactct ttggcagtgg aacaacactt gttgtcacag            400
ataaacaact tgatgcagat gtttccccca agcccactat ttttcttcct            450
tcaattgctg aaacaaagct ccagaaggct ggaacatacc tttgtcttct            500
tgagaaattt ttccctgatg ttattaagat acattggcaa gaaaagaaga            550
gcaacacgat tctgggatcc caggagggga acaccatgaa gactaacgac            600
acatacatga aatttagctg gttaacggtg ccagaaaagt cactggacaa            650
agaacacaga tgtatcgtca gacatgagaa taataaaaac ggagttgatc            700
aagaaattat ctttcctcca ataaagacag atgtcatcac aatggatccc            750
aaagacaatt gttcaaaaga tgcaaatgat acactactgc tgcagctcac            800
aaacacctct gcatattaca tgtacctcct cctgctcctc aagagtgtgg            850
tctattttgc catcatcacc tgctgtctgc ttagaagaac ggctttctgc            900
tgcaatggag agaaa                                                  915

<210>  32
<211>  897
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRD full length wild type clone 4

<400>  32
atgctgttct ccagcctgct gtgtgtattt gtggccttca gctactctgg            50
atcaagtgtg gcccagaagg ttactcaagc ccagtcatca gtatccatgc            100
cagtgaggaa agcagtcacc ctgaactgcc tgtatgaaac aagttggtgg            150
tcatattata ttttttggta caagcaactt cccagcaaag agatgatttt            200
ccttattcgc cagggttctg atgaacagaa tgcaaaaagt ggtcgctatt            250
ctgtcaactt caagaaagca gcgaaatccg tcgccttaac catttcagcc            300
ttacagctag aagattcagc aaagtacttt tgtgctcttg gggggctggg            350
ctggggatac gcaggcgatg aagggggtgg aaaactaacc gataaactca            400
tctttggaaa aggaacccgt gtgactgtgg aaccaagaag tcagcctcat            450
accaaaccat ccgtttttgt catgaaaaat ggaacaaatg tcgcttgtct            500
ggtgaaggaa ttctacccca aggatataag aataaatctc gtgtcatcca            550
agaagataac agagtttgat cctgctattg tcatctctcc cagtgggaag            600
tacaatgctg tcaagcttgg taaatatgaa gattcaaatt cagtgacatg            650
ttcagttcaa cacgacaata aaactgtgca ctccactgac tttgaagtga            700
agacagattc tacagatcac gtaaaaccaa aggaaactga aaacacaaag            750
caaccttcaa agagctgcca taaacccaaa gccatagttc ataccgagaa            800
ggtgaacatg atgtccctca cagtgcttgg gctacgaatg ctgtttgcaa            850
agactgttgc cgtcaatttt ctcttgactg ccaagttatt tttcttg               897

<210>  33
<211>  984
<212>  DNA
<213>  Homo sapiens

<220>
<223>  TRG full length wild type clone 4

<400>  33
atgctgtcac tgctccacac atcaacgctg gcagtccttg gggctctgtg            50
tgtatatggt gcaggtcacc tagagcaacc tcaaatttcc agtactaaaa            100
cgctgtcaaa aacagcccgc ctggaatgtg tggtgtctgg aataacaatt            150
tctgcaacat ctgtatattg gtatcgagag agacctggtg aagtcataca            200
gttcctggtg tccatttcat atgacggcac tgtcagaaag gaatccggca            250
ttccgtcagg caaatttgag gtggatagga tacctgaaac gtctacatcc            300
actctcacca ttcacaatgt agagaaacag gacatagcta cctactactg            350
tgccttgtgg gaggtgcatc ccaattataa gaaactcttt ggcagtggaa            400
caacacttgt tgtcacagat aaacaacttg atgcagatgt ttcccccaag            450
cccactattt ttcttccttc gattgctgaa acaaaactcc agaaggctgg            500
aacatacctt tgtcttcttg agaaattttt cccagatatt attaagatac            550
attggcaaga aaagaagagc aacacgattc tgggatccca ggaggggaac            600
accatgaaga ctaacgacac atacatgaaa tttagctggt taacggtgcc            650
agaagagtca ctggacaaag aacacagatg tatcgtcaga catgagaata            700
ataaaaacgg aattgatcaa gaaattatct ttcctccaat aaagacagat            750
gtcaccacag tggatcccaa atacaattat tcaaaggatg caaatgatgt            800
catcacaatg gatcccaaag acaattggtc aaaagatgca aatgatacac            850
tactgctgca gctcacaaac acctctgcat attacatgta cctcctcctg            900
ctcctcaaga gtgtggtcta ttttgccatc atcacctgct gtctgcttgg            950
aagaacggct ttctgctgca atggagagaa atca                             984

<210>  34
<211>  2844
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG clone 2-41BBL-OX40-TRD clone 2

<400>  34
atggagtggg ccctggccgt gctgctggcc tttctgagcc ctgccagcca            50
gaagtccagc aacctggaag gccggaccaa gagcgtgatc cggcagacag            100
gcagcagcgc cgagatcacc tgtgacctgg ccgagggcag caccggctac            150
atccactggt atctgcacca agaaggcaag gccccccagc ggctgctgta            200
ctacgacagc tacaccagct ccgtggtgct ggaaagcggc atcagccccg            250
ggaagtacga cacctacggc agcacccgga agaacctgcg gatgatcctg            300
cggaacctga tcgagaacga cagcggcgtg tactactgtg ccacatggga            350
cctgcacaag aagctgttcg gcagcggcac aaccctggtg gttacagaca            400
agcagctgga cgccgacgtg tcccccaagc ctaccatctt cctgccctca            450
attgctgaga caaagctgca gaaggccggc acctacctgt gcctgctgga            500
aaagttcttc ccagacatca tcaagatcca ctggcaagaa aagaagtcca            550
acaccatcct gggcagccaa gaaggcaaca ccatgaagac caacgacacc            600
tacatgaagt tcagctggct gaccgtgccc gaggagtccc tggacaaaga            650
acaccggtgc atcgtgcggc acgagaacaa caagaacggc atcgaccaag            700
aaatcatctt cccacccatc aagaccgacg tgacaacagt ggaccccaag            750
tacaactaca gcaaggacgc caacgacgtg atcacaatgg accccaagga            800
caactggagc aaggacgcca acgataccct gctgctgcag ctgacaaaca            850
ccagcgccta ctacatgtac ttgttgctgc tgctgaagtc cgtggtgtac            900
ttcgccatca tcacatgctg cctgctgggc cggaccgcct tctgctgcaa            950
cggcgagaag agcggatctg gcgccaccaa tttcagcctg ctgaaacagg            1000
ctggcgacgt ggaagagaac cctgggccca tgctggggcg cgaccagagg            1050
ctgccacctg acgcacacaa gccacctggt gggggctcat ttcgaactcc            1100
catccaggaa gagcaggccg acgcacacag tacccttgcc aaaatcacta            1150
gtggaagtta tgccagtgac gcatctctcg atcccgaagc cccttggcca            1200
ccggcgccaa gagctagagc ttgcagagtg ttgccttggg ctttggtggc            1250
cggactgctg ctcctgctgc tgctggctgc tgcctgtgcc gtgtttctcg            1300
catgtccttg ggctgtgtcc ggtgcaagag cctctcctgg atctgccgcg            1350
agtccgcgcc tgcgagaggg accagaattg tcaccggatg accctgcagg            1400
ccttctcgat ctcaggcaag gaatgtttgc gcagctggtg gcacaaaacg            1450
tgttgcttat agacggacca cttagctggt attctgatcc cggcctggcc            1500
ggggtttcat tgaccggcgg cctttcctac aaggaagata ccaaggaact            1550
ggtggtcgcc aaggccggag tatactatgt tttcttccaa ttggagttgc            1600
ggcgcgtcgt ggcaggggaa gggagcggtt ctgtctcttt ggctctccac            1650
ctgcaaccct tgagatccgc ggctggagct gcagctttgg cgctcactgt            1700
tgacctgcca cctgcaagtt ccgaggctcg gaactcagcg ttcgggtttc            1750
aaggcagact gctgcacctg agcgccgggc aaagacttgg tgtacacttg            1800
cacactgagg ctagagcccg ccacgcttgg caactcacac aaggggctac            1850
agtgcttggc ctgttccgag taacgcccga aattccagcg ggcctgccaa            1900
gtcctagatc tgaaggcagc ggcgaaggcc gcggcagcct gctgacctgc            1950
ggagacgtgg aagaaaaccc tggcccgatg atcctgaccg tgggcttcag            2000
cttcctgttc ttctaccggg gcaccctgtg cgacaaagtg acacagtcta            2050
gccccgatca gacagtggcc tctggatctg aagtggtgct gctgtgcacc            2100
tacgacaccg tgtacagcaa ccccgacctg ttctggtaca gaatcagacc            2150
cgactacagc ttccagttcg tgttctacgg cgacaacagc agaagcgagg            2200
gcgccgattt cacccagggc agattttccg tgaagcacat cctgacacag            2250
aaagccttcc acctggtcat cagccctgtg cggacagagg atagcgccac            2300
ctactattgt gcttgtggcc tgcctagaag cctggccgac aagctgatct            2350
tcggcaaggg cacccgggtg accgtggagc ccagaagcca gccccacacc            2400
aagcccagcg tgttcgtgat gaagaacggc accaacgtgg cctgcctggt            2450
gaaagagttc taccccaagg acatccggat caacctggtg tccagcaaga            2500
agatcaccga gttcgacccc gccatcgtga tcagccccag cggcaagtac            2550
aacgccgtga agctgggcaa gtacgaggac agcaacagcg tgacctgcag            2600
cgtgcagcac gacaacaaga ccgtgcacag caccgacttc gaggtgaaaa            2650
ccgactccac cgaccacgtg aagcccaaag agaccgagaa caccaagcag            2700
cccagcaaga gctgccacaa gcccaaggcc atcgtgcaca ccgagaaggt            2750
gaacatgatg agcctgaccg tgctgggcct gcggatgctg ttcgccaaga            2800
cagtggccgt gaacttcctg ctgaccgcca agctgttctt cctg                  2844

<210>  35
<211>  2895
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG clone 4-41BBL-OX40-TRD clone 4

<400>  35
atggtgtccc tgctgcacgc cagcaccctg gccgtgctgg gcgccctgtg            50
cgtgtatggc gccggacacc tggaacagcc ccagatcagc agcaccaaga            100
ccctgagcaa gaccgccagg ctggaatgcg tggtgtccgg catcaccatc            150
agcgccacct ccgtgtactg gtacagagag agacccggcg aggtcatcca            200
gttcctggtg tccatcagct acgacggcac cgtgcggaaa gagagcggca            250
tccccagcgg caagttcgag gtggacagaa tccccgagac cagcacctcc            300
accctgacca tccacaacgt ggagaagcag gacatcgcca cctactactg            350
tgctctgtgg gaagtgcacc ccaactacaa gaagctgttc ggcagcggca            400
ccacactggt ggttacagac aagcagctgg acgccgacgt gtcccccaag            450
cctaccatct tcctgccctc aattgctgag acaaagctgc agaaggccgg            500
cacctacctg tgcctgctgg aaaagttctt cccagacatc atcaagatcc            550
actggcaaga aaagaagtcc aacaccatcc tgggcagcca agaaggcaac            600
accatgaaga ccaacgacac ctacatgaag ttcagctggc tgaccgtgcc            650
cgaggagtcc ctggacaaag aacaccggtg catcgtgcgg cacgagaaca            700
acaagaacgg catcgaccaa gaaatcatct tcccacccat caagaccgac            750
gtgacaacag tggaccccaa gtacaactac agcaaggacg ccaacgacgt            800
gatcacaatg gaccccaagg acaactggag caaggacgcc aacgataccc            850
tgctgctgca gctgacaaac accagcgcct actacatgta cttgttgctg            900
ctgctgaagt ccgtggtgta cttcgccatc atcacatgct gcctgctggg            950
ccggaccgcc ttctgctgca acggcgagaa gagcggatct ggcgccacca            1000
atttcagcct gctgaaacag gctggcgacg tggaagagaa ccctgggccc            1050
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg            1100
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca            1150
gtacccttgc caaaatcact agtggaagtt atgccagtga cgcatctctc            1200
gatcccgaag ccccttggcc accggcgcca agagctagag cttgcagagt            1250
gttgccttgg gctttggtgg ccggactgct gctcctgctg ctgctggctg            1300
ctgcctgtgc cgtgtttctc gcatgtcctt gggctgtgtc cggtgcaaga            1350
gcctctcctg gatctgccgc gagtccgcgc ctgcgagagg gaccagaatt            1400
gtcaccggat gaccctgcag gccttctcga tctcaggcaa ggaatgtttg            1450
cgcagctggt ggcacaaaac gtgttgctta tagacggacc acttagctgg            1500
tattctgatc ccggcctggc cggggtttca ttgaccggcg gcctttccta            1550
caaggaagat accaaggaac tggtggtcgc caaggccgga gtatactatg            1600
ttttcttcca attggagttg cggcgcgtcg tggcagggga agggagcggt            1650
tctgtctctt tggctctcca cctgcaaccc ttgagatccg cggctggagc            1700
tgcagctttg gcgctcactg ttgacctgcc acctgcaagt tccgaggctc            1750
ggaactcagc gttcgggttt caaggcagac tgctgcacct gagcgccggg            1800
caaagacttg gtgtacactt gcacactgag gctagagccc gccacgcttg            1850
gcaactcaca caaggggcta cagtgcttgg cctgttccga gtaacgcccg            1900
aaattccagc gggcctgcca agtcctagat ctgaaggcag cggcgaaggc            1950
cgcggcagcc tgctgacctg cggagacgtg gaagaaaacc ctggcccgat            2000
ggtgttcagc agcctgctgt gcgtgttcgt ggccttcagc tacagcggca            2050
gcagcgtggc ccagaaagtg acccaggccc agagcagcgt gtccatgcct            2100
gtgcggaagg ccgtgaccct gaactgcctg tacgagacaa gctggtggtc            2150
ctactacatc ttctggtaca agcagctgcc cagcaaagag atgatcttcc            2200
tgatccggca gggcagcgac gagcagaacg ccaagagcgg ccggtacagc            2250
gtgaacttca agaaagccgc caagtccgtg gccctgacca tcagcgccct            2300
gcagctggaa gatagcgcca agtatttctg tgcccttgga ggactcggat            2350
ggggatatgc tggcgacgaa ggcggaggca agctgaccga taagctgatc            2400
ttcggcaagg gcacccgggt gaccgtggag cccagaagcc agccccacac            2450
caagcccagc gtgttcgtga tgaagaacgg caccaacgtg gcctgcctgg            2500
tgaaagagtt ctaccccaag gacatccgga tcaacctggt gtccagcaag            2550
aagatcaccg agttcgaccc cgccatcgtg atcagcccca gcggcaagta            2600
caacgccgtg aagctgggca agtacgagga cagcaacagc gtgacctgca            2650
gcgtgcagca cgacaacaag accgtgcaca gcaccgactt cgaggtgaaa            2700
accgactcca ccgaccacgt gaagcccaaa gagaccgaga acaccaagca            2750
gcccagcaag agctgccaca agcccaaggc catcgtgcac accgagaagg            2800
tgaacatgat gagcctgacc gtgctgggcc tgcggatgct gttcgccaag            2850
acagtggccg tgaacttcct gctgaccgcc aagctgttct tcctg                 2895

<210>  36
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  41BBL-OX40

<400>  36
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg            50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca            100
gtacccttgc caaaatcact agtggaagtt atgccagtga cgcatctctc            150
gatcccgaag ccccttggcc accggcgcca agagctagag cttgcagagt            200
gttgccttgg gctttggtgg ccggactgct gctcctgctg ctgctggctg            250
ctgcctgtgc cgtgtttctc gcatgtcctt gggctgtgtc cggtgcaaga            300
gcctctcctg gatctgccgc gagtccgcgc ctgcgagagg gaccagaatt            350
gtcaccggat gaccctgcag gccttctcga tctcaggcaa ggaatgtttg            400
cgcagctggt ggcacaaaac gtgttgctta tagacggacc acttagctgg            450
tattctgatc ccggcctggc cggggtttca ttgaccggcg gcctttccta            500
caaggaagat accaaggaac tggtggtcgc caaggccgga gtatactatg            550
ttttcttcca attggagttg cggcgcgtcg tggcagggga agggagcggt            600
tctgtctctt tggctctcca cctgcaaccc ttgagatccg cggctggagc            650
tgcagctttg gcgctcactg ttgacctgcc acctgcaagt tccgaggctc            700
ggaactcagc gttcgggttt caaggcagac tgctgcacct gagcgccggg            750
caaagacttg gtgtacactt gcacactgag gctagagccc gccacgcttg            800
gcaactcaca caaggggcta cagtgcttgg cctgttccga gtaacgcccg            850
aaattccagc gggcctgcca agtcctagat ctgaa                            885

<210>  37
<211>  894
<212>  DNA
<213>  Artificial sequence

<220>
<223>  41BBL-OX40_GSG

<400>  37
atgctggggc gcgaccagag gctgccacct gacgcacaca agccacctgg            50
tgggggctca tttcgaactc ccatccagga agagcaggcc gacgcacaca            100
gtacccttgc caaaatcact agtggaagtt atgccagtga cgcatctctc            150
gatcccgaag ccccttggcc accggcgcca agagctagag cttgcagagt            200
gttgccttgg gctttggtgg ccggactgct gctcctgctg ctgctggctg            250
ctgcctgtgc cgtgtttctc gcatgtcctt gggctgtgtc cggtgcaaga            300
gcctctcctg gatctgccgc gagtccgcgc ctgcgagagg gaccagaatt            350
gtcaccggat gaccctgcag gccttctcga tctcaggcaa ggaatgtttg            400
cgcagctggt ggcacaaaac gtgttgctta tagacggacc acttagctgg            450
tattctgatc ccggcctggc cggggtttca ttgaccggcg gcctttccta            500
caaggaagat accaaggaac tggtggtcgc caaggccgga gtatactatg            550
ttttcttcca attggagttg cggcgcgtcg tggcagggga agggagcggt            600
tctgtctctt tggctctcca cctgcaaccc ttgagatccg cggctggagc            650
tgcagctttg gcgctcactg ttgacctgcc acctgcaagt tccgaggctc            700
ggaactcagc gttcgggttt caaggcagac tgctgcacct gagcgccggg            750
caaagacttg gtgtacactt gcacactgag gctagagccc gccacgcttg            800
gcaactcaca caaggggcta cagtgcttgg cctgttccga gtaacgcccg            850
aaattccagc gggcctgcca agtcctagat ctgaaggcag cggc                  894

<210>  38
<211>  298
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40_GSG

<400>  38
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Ser Gly 
                290                 295             

<210>  39
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-EC

<400>  39
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
1               5                   10                  15  

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                20                  25                  30  

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                35                  40                  45  

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                50                  55                  60  

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                65                  70                  75  

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                80                  85                  90  

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                95                  100                 105 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                110                 115                 120 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                125                 130                 135 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                140                 145                 150 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                155                 160                 165 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                170                 175                 180 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                185                 190                 195 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                200                 205 

<210>  40
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L

<400>  40
Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
1               5                   10                  15  

Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
                20                  25                  30  

Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile 
                35                  40                  45  

Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
                50                  55                  60  

Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
                65                  70                  75  

Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
                80                  85                  90  

Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
                95                  100                 105 

Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
                110                 115                 120 

Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                125                 130             

<210>  41
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86

<400>  41
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro 
                245         

<210>  42
<211>  212
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK

<400>  42
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His Val Tyr 
                200                 205                 210 

Leu Pro 
        

<210>  43
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Reverse 41BBL

<400>  43
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15  

Pro Ala Phe Leu Leu Ile Pro Asp Gln Gly Met Phe Ala Gln Leu 
                20                  25                  30  

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                35                  40                  45  

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                50                  55                  60  

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                65                  70                  75  

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                80                  85                  90  

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                95                  100                 105 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                110                 115                 120 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                125                 130                 135 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                140                 145                 150 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                155                 160                 165 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                170                 175                 180 

Ala Gly Leu Pro Ser Pro Arg Ser Glu Arg Leu Asp Leu Leu Gly 
                185                 190                 195 

Ala Pro Asp Asp Pro Ser Leu Glu Pro Gly Glu Arg Leu Arg Pro 
                200                 205                 210 

Ser Ala Ala Ser Gly Pro Ser Ala Arg Ala 
                215                 220 

<210>  44
<211>  347
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL  CD86 IgV domain

<400>  44
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
1               5                   10                  15  

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                20                  25                  30  

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                35                  40                  45  

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                50                  55                  60  

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                65                  70                  75  

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                80                  85                  90  

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                95                  100                 105 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                110                 115                 120 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                125                 130                 135 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                140                 145                 150 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                155                 160                 165 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                170                 175                 180 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                185                 190                 195 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Ser Leu Asn Gly Gly 
                200                 205                 210 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                215                 220                 225 

Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser Ala Pro Leu Lys Ile 
                230                 235                 240 

Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala 
                245                 250                 255 

Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln 
                260                 265                 270 

Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
                275                 280                 285 

Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe 
                290                 295                 300 

Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
                305                 310                 315 

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
                320                 325                 330 

Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                335                 340                 345 

Ala Asn 
        

<210>  45
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD

<400>  45
Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15  

Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
                20                  25                  30  

Ser Thr Leu Ala Lys Ile 
                35      

<210>  46
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-REV

<400>  46
Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu Gln Ile 
1               5                   10                  15  

Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala Asp Pro 
                20                  25                  30  

Pro Leu Arg Gln Asp Arg 
                35      

<210>  47
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-TM

<400>  47
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
1               5                   10                  15  

Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln 
                20                  25                  30  

Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
                35                  40                  45  

Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu 
                50                  55                  60  

Ala Lys Ile 
            

<210>  48
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD

<400>  48
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15  

Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                20                  25                  30  

Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40          

<210>  49
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD-REV

<400>  49
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  




<210>  50
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NKp80-ICD

<400>  50
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp 
                35      

<210>  51
<211>  224
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL18RAP-ICD

<400>  51
Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu 
1               5                   10                  15  

Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys 
                20                  25                  30  

Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe 
                35                  40                  45  

Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu 
                50                  55                  60  

Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu 
                65                  70                  75  

Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu 
                80                  85                  90  

Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
                95                  100                 105 

Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln 
                110                 115                 120 

Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile 
                125                 130                 135 

Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His 
                140                 145                 150 

Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg 
                155                 160                 165 

Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met 
                170                 175                 180 

Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn 
                185                 190                 195 

Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser 
                200                 205                 210 

Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                215                 220                 

<210>  52
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-ICD-TM

<400>  52
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
1               5                   10                  15  

Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly 
                20                  25                  30  

Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                35                  40                  45  

Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                50                  55                  60  

Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                65                  

<210>  53
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-ALYLLR

<400>  53
Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu Gln Ile 
1               5                   10                  15  

Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala Asp Pro 
                20                  25                  30  

Pro Leu Arg Gln Asp Arg Arg Leu Leu Tyr Leu Ala 
                35                  40          

<210>  54
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-ICD-ALYLLR-REV

<400>  54
Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala 
1               5                   10                  15  

His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
                20                  25                  30  

Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                35                  40          

<210>  55
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRAF domain OX40

<400>  55
Pro Ile Gln Glu Glu Gln 
1               5       

<210>  56
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YMTLN motif

<400>  56
Tyr Met Thr Leu Asn 
1               5   

<210>  57
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRAF domain 41BB

<400>  57
Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
1               5                   10                  15  

Glu Glu Glu 
            

<210>  58
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40-TM

<400>  58
Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
1               5                   10                  15  

Pro Leu Ala Ile Leu Leu 
                20      

<210>  59
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-TM

<400>  59
Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu 
1               5                   10                  15  

Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
                20                  25          

<210>  60
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BB-TM

<400>  60
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
1               5                   10                  15  

Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
                20                  25          

<210>  61
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-TM

<400>  61
Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
1               5                   10                  15  

Ala Cys Ala Val Phe Leu 
                20      

<210>  62
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NKp80-TM

<400>  62
Ile Leu Leu Gly Ile Ser Gly Thr Val Asn Gly Ile Leu Thr Leu 
1               5                   10                  15  

Thr Leu Ile Ser Leu Ile 
                20      

<210>  63
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-TM

<400>  63
Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
1               5                   10                  15  

Phe Cys Leu Ile Leu Trp 
                20      

<210>  64
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL18RAP-TM

<400>  64
Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu 
1               5                   10                  15  

Val Ala Val Leu 
                

<210>  65
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-TM

<400>  65
Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala 
1               5                   10                  15  

Ala Ile Ile Phe Gly Val 
                20      

<210>  66
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  66
Thr Ser Gly Ser 
1               

<210>  67
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  67
Gly Gly Gly Gly Ser 
1               5   

<210>  68
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  68
Gly Gly Gly Ser 
1               

<210>  69
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  69
gg                                                                2

<210>  70
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  70
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg 
1               5                   10                  15  

Ser Leu Asp 
            

<210>  71
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  71
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  

<210>  72
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  72
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          

<210>  73
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  73
Glu Ala Ala Ala Lys 
1               5   

<210>  74
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  74
Glu Ala Ala Ala Arg 
1               5   

<210>  75
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  75
Pro Ala Pro Ala Pro 
1               5   

<210>  76
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  76
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          

<210>  77
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Rigid linker

<400>  77
Ile Leu Thr His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr 
1               5                   10                  15  

Asn Ser Asn Asn Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala 
                20                  25                  30  

Gln Leu Glu Ala Gln Cys Gln Glu Pro Cys Lys Asp Thr Val Gln 
                35                  40                  45  

Ile His Asp Ile Thr Gly 
                50      

<210>  78
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  78
Gly Gly Ser 
1           

<210>  79
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  79
Ser Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser 
                20                  25                  30  




<210>  80
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  80
Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  

Gly Gly Ser Leu Gln 
                20  

<210>  81
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  81
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
                20                  25      

<210>  82
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker

<400>  82
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  




<210>  83
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40

<400>  83
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                290                 295 

<210>  84
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W-OX40rev

<400>  84
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Trp Pro 
                35                  40                  45  

Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu 
                50                  55                  60  

Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala 
                65                  70                  75  

Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser 
                80                  85                  90  

Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
                95                  100                 105 

Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
                110                 115                 120 

Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
                125                 130                 135 

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                140                 145                 150 

Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
                155                 160                 165 

Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                170                 175                 180 

Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                185                 190                 195 

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                200                 205                 210 

Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
                215                 220                 225 

Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
                230                 235                 240 

Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
                245                 250                 255 

Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                260                 265                 270 

Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280             

<210>  85
<211>  288
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-NKp80

<400>  85
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp Tyr Ala Ser Asp Ala Ser Leu Asp Pro 
                35                  40                  45  

Glu Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val 
                50                  55                  60  

Leu Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu 
                65                  70                  75  

Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser 
                80                  85                  90  

Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
                95                  100                 105 

Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                110                 115                 120 

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                125                 130                 135 

Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                140                 145                 150 

Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
                155                 160                 165 

Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
                170                 175                 180 

Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                185                 190                 195 

Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                200                 205                 210 

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                215                 220                 225 

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                230                 235                 240 

Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                245                 250                 255 

Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                260                 265                 270 

Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
                275                 280                 285 

Arg Ser Glu 
            

<210>  86
<211>  264
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-NKp80

<400>  86
Met Gln Asp Glu Asp Gly Tyr Met Thr Leu Asn Val Gln Ser Lys 
1               5                   10                  15  

Lys Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr 
                20                  25                  30  

Ser Val Thr Leu His Trp Tyr Lys Trp Ala Leu Val Ala Gly Leu 
                35                  40                  45  

Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala 
                50                  55                  60  

Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
                65                  70                  75  

Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
                80                  85                  90  

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
                95                  100                 105 

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                110                 115                 120 

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                125                 130                 135 

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                140                 145                 150 

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                155                 160                 165 

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                170                 175                 180 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                185                 190                 195 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                200                 205                 210 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                215                 220                 225 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                230                 235                 240 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                245                 250                 255 

Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 

<210>  87
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-41BB_1

<400>  87
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Thr Ser Gly Ser Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly 
                50                  55                  60  

Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val 
                65                  70                  75  

Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr 
                80                  85                  90  

Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro 
                95                  100                 105 

Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
                110                 115                 120 

Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
                125                 130                 135 

Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
                140                 145                 150 

Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
                155                 160                 165 

His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
                170                 175                 180 

Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                185                 190                 195 

Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                200                 205                 210 

Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
                215                 220                 225 

Gly Glu Phe Cys Val Leu 
                230     

<210>  88
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L- 41BB_2

<400>  88
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Gly Gly Ser Ala Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly 
                50                  55                  60  

Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val 
                65                  70                  75  

Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr 
                80                  85                  90  

Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro 
                95                  100                 105 

Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
                110                 115                 120 

Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
                125                 130                 135 

Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu 
                140                 145                 150 

Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu 
                155                 160                 165 

His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
                170                 175                 180 

Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                185                 190                 195 

Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
                200                 205                 210 

Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro 
                215                 220                 225 

Gly Glu Phe Cys Val Leu 
                230     

<210>  89
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L-41BBrev

<400>  89
Met Leu Gly Leu Glu Cys Gly Gly Glu Glu Glu Glu Pro Phe Arg 
1               5                   10                  15  

Cys Ser Cys Gly Asp Glu Glu Gln Thr Thr Gln Val Pro Arg Met 
                20                  25                  30  

Phe Pro Gln Lys Phe Ile Tyr Leu Leu Lys Lys Arg Gly Arg Lys 
                35                  40                  45  

Leu Gly Gly Ser Ala Glu Arg Val Gln Pro Leu Glu Glu Asn Val 
                50                  55                  60  

Gly Asn Ala Ala Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu 
                65                  70                  75  

Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr 
                80                  85                  90  

Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser His Arg Tyr 
                95                  100                 105 

Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys 
                110                 115                 120 

Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met 
                125                 130                 135 

Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr 
                140                 145                 150 

Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser 
                155                 160                 165 

Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
                170                 175                 180 

Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                185                 190                 195 

Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp 
                200                 205                 210 

Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                215                 220                 225 

Pro Gly Glu Phe Cys Val Leu 
                230         

<210>  90
<211>  368
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-OX40

<400>  90
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe Gly 
                320                 325                 330 

Ser Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro 
                335                 340                 345 

Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
                350                 355                 360 

Ala His Ser Thr Leu Ala Lys Ile 
                365             

<210>  91
<211>  313
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86delP276-OX40

<400>  91
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Gly Arg Asp Gln Arg Leu Pro Pro Asp 
                275                 280                 285 

Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                290                 295                 300 

Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                305                 310             

<210>  92
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL

<400>  92
Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro 
1               5                   10                  15  

Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
                20                  25                  30  

Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val 
                35                  40                  45  

Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro 
                50                  55                  60  

Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser 
                65                  70                  75  

Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
                80                  85                  90  

Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
                95                  100                 105 

Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
                110                 115                 120 

Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
                125                 130                 135 

Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
                140                 145                 150 

Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
                155                 160                 165 

Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                170                 175                 180 

Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe 
                185                 190                 195 

Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                200                 205                 210 

Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                215                 220                 225 

Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
                230                 235                 240 

Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250         

<210>  93
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-mincyto

<400>  93
Met Ser Lys Ser Thr Gly Ser Trp Ala Leu Val Ala Gly Leu Leu 
1               5                   10                  15  

Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys 
                20                  25                  30  

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala 
                35                  40                  45  

Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
                50                  55                  60  

Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                65                  70                  75  

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
                80                  85                  90  

Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
                95                  100                 105 

Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
                110                 115                 120 

Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
                125                 130                 135 

Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
                140                 145                 150 

Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
                155                 160                 165 

Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
                170                 175                 180 

Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
                185                 190                 195 

His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly 
                200                 205                 210 

Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                215                 220                 225 

Gly Leu Pro Ser Pro Arg Ser Glu 
                230             

<210>  94
<211>  228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W

<400>  94
Met Glu Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15  

Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser 
                20                  25                  30  

Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg 
                35                  40                  45  

Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
                50                  55                  60  

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu 
                65                  70                  75  

Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
                80                  85                  90  

Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
                95                  100                 105 

Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
                110                 115                 120 

Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
                125                 130                 135 

Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                140                 145                 150 

Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
                155                 160                 165 

Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
                170                 175                 180 

Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
                185                 190                 195 

Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                200                 205                 210 

Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
                215                 220                 225 

Arg Ser Glu 
            

<210>  95
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40rev

<400>  95
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                290                 295 

<210>  96
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-rev extra-OX40tm-cyto

<400>  96
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15  

Pro Ala Phe Leu Leu Ile Pro Asp Gln Gly Met Phe Ala Gln Leu 
                20                  25                  30  

Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                35                  40                  45  

Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
                50                  55                  60  

Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
                65                  70                  75  

Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
                80                  85                  90  

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
                95                  100                 105 

Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
                110                 115                 120 

Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
                125                 130                 135 

Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
                140                 145                 150 

Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
                155                 160                 165 

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro 
                170                 175                 180 

Ala Gly Leu Pro Ser Pro Arg Ser Glu Arg Leu Asp Leu Leu Gly 
                185                 190                 195 

Ala Pro Asp Asp Pro Ser Leu Glu Pro Gly Glu Arg Leu Arg Pro 
                200                 205                 210 

Ser Ala Ala Ser Gly Pro Ser Ala Arg Ala Val Ala Ala Ile Leu 
                215                 220                 225 

Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu 
                230                 235                 240 

Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp 
                245                 250                 255 

Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
                260                 265                 270 

Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                275                 280             

<210>  97
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-OX40

<400>  97
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Trp Ala 
                35                  40                  45  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                50                  55                  60  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                65                  70                  75  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                80                  85                  90  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                95                  100                 105 

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                110                 115                 120 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                125                 130                 135 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                140                 145                 150 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                155                 160                 165 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                170                 175                 180 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                185                 190                 195 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                200                 205                 210 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                215                 220                 225 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                230                 235                 240 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                245                 250                 255 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 265                 

<210>  98
<211>  281
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL13W-OX40rev

<400>  98
Met Glu Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu Glu 
1               5                   10                  15  

Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His Ala 
                20                  25                  30  

Asp Pro Pro Leu Arg Gln Asp Arg Arg Leu Leu Trp Pro Pro Ala 
                35                  40                  45  

Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala 
                50                  55                  60  

Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
                65                  70                  75  

Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly 
                80                  85                  90  

Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro 
                95                  100                 105 

Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
                110                 115                 120 

Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
                125                 130                 135 

Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
                140                 145                 150 

Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                155                 160                 165 

Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                170                 175                 180 

Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
                185                 190                 195 

Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
                200                 205                 210 

Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
                215                 220                 225 

Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly 
                230                 235                 240 

Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
                245                 250                 255 

Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
                260                 265                 270 

Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280     

<210>  99
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-mincyto-OX40rev

<400>  99
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Thr Ser Gly Ser Trp Ala 
                35                  40                  45  

Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys 
                50                  55                  60  

Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala 
                65                  70                  75  

Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu 
                80                  85                  90  

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
                95                  100                 105 

Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
                110                 115                 120 

Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
                125                 130                 135 

Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
                140                 145                 150 

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
                155                 160                 165 

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu 
                170                 175                 180 

His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                185                 190                 195 

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
                200                 205                 210 

Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
                215                 220                 225 

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                230                 235                 240 

Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
                245                 250                 255 

Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                260                 265                 

<210>  100
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40ENrev

<400>  100
Met Leu Gly Ile Lys Ala Leu Thr Ser His Ala Asp Ala Gln Glu 
1               5                   10                  15  

Glu Gln Ile Pro Thr Arg Phe Ser Gly Gly Gly Pro Pro Lys His 
                20                  25                  30  

Ala Asp Pro Pro Leu Arg Gln Asp Arg Arg Leu Leu Tyr Leu Ala 
                35                  40                  45  

Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala 
                50                  55                  60  

Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
                65                  70                  75  

Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
                80                  85                  90  

Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala 
                95                  100                 105 

Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
                110                 115                 120 

Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                125                 130                 135 

Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                140                 145                 150 

Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                155                 160                 165 

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
                170                 175                 180 

Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                185                 190                 195 

Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                200                 205                 210 

Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                215                 220                 225 

Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                230                 235                 240 

Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                245                 250                 255 

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                260                 265                 270 

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                275                 280                 285 

Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
                290                 295                 300 

Glu 
    

<210>  101
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40EN

<400>  101
Met Leu Gly Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro 
1               5                   10                  15  

Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
                20                  25                  30  

Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                35                  40                  45  

Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala 
                50                  55                  60  

Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro 
                65                  70                  75  

Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala 
                80                  85                  90  

Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala 
                95                  100                 105 

Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly 
                110                 115                 120 

Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
                125                 130                 135 

Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
                140                 145                 150 

Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                155                 160                 165 

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu 
                170                 175                 180 

Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
                185                 190                 195 

Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
                200                 205                 210 

Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                215                 220                 225 

Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
                230                 235                 240 

Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
                245                 250                 255 

Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
                260                 265                 270 

His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                275                 280                 285 

Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser 
                290                 295                 300 

Glu 
    

<210>  102
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBLmincyto-13alink-OX40

<400>  102
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Ser Leu Asn Gly Gly Gly 
                35                  40                  45  

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                50                  55                  60  

Gly Ser Gly Gly Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu 
                65                  70                  75  

Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp 
                80                  85                  90  

Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro 
                95                  100                 105 

Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
                110                 115                 120 

Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                125                 130                 135 

Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
                140                 145                 150 

Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
                155                 160                 165 

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
                170                 175                 180 

Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
                185                 190                 195 

Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
                200                 205                 210 

Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
                215                 220                 225 

Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
                230                 235                 240 

Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                245                 250                 255 

Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                260                 265                 270 

Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
                275                 280                 285 

Pro Ser Pro Arg Ser Glu 
                290     

<210>  103
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40Lmincyto-41BBrev

<400>  103
Met Leu Gly Leu Glu Cys Gly Gly Glu Glu Glu Glu Pro Phe Arg 
1               5                   10                  15  

Cys Ser Cys Gly Asp Glu Glu Gln Thr Thr Gln Val Pro Arg Met 
                20                  25                  30  

Phe Pro Gln Lys Phe Ile Tyr Leu Leu Lys Lys Arg Gly Arg Lys 
                35                  40                  45  

Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly Leu Leu Leu 
                50                  55                  60  

Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu Gln Val Ser 
                65                  70                  75  

His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu 
                80                  85                  90  

Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
                95                  100                 105 

Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
                110                 115                 120 

Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val 
                125                 130                 135 

Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
                140                 145                 150 

Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu 
                155                 160                 165 

Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr 
                170                 175                 180 

Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile 
                185                 190                 195 

His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                200                 205 

<210>  104
<211>  183
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40L WT

<400>  104
Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala 
1               5                   10                  15  

Arg Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val 
                20                  25                  30  

Ile Gln Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu 
                35                  40                  45  

His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln 
                50                  55                  60  

Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
                65                  70                  75  

Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn 
                80                  85                  90  

Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu 
                95                  100                 105 

Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln 
                110                 115                 120 

Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val 
                125                 130                 135 

Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr 
                140                 145                 150 

Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val 
                155                 160                 165 

Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe 
                170                 175                 180 

Cys Val Leu 
            

<210>  105
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40Lmincyto-41BB

<400>  105
Met Leu Gly Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
1               5                   10                  15  

Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                20                  25                  30  

Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                35                  40                  45  

Gly Gly Ser Leu Leu Leu Val Ala Ser Val Ile Gln Gly Leu Gly 
                50                  55                  60  

Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser Ala Leu 
                65                  70                  75  

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln 
                80                  85                  90  

Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
                95                  100                 105 

Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile 
                110                 115                 120 

Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser 
                125                 130                 135 

Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
                140                 145                 150 

Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val 
                155                 160                 165 

Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
                170                 175                 180 

Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu 
                185                 190                 195 

Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                200                 205             

<210>  106
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86 WT

<400>  106
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                320                 325                 

<210>  107
<211>  276
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-delP276

<400>  107
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro 
                275     

<210>  108
<211>  268
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86mincyto

<400>  108
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp 
                260                 265             

<210>  109
<211>  490
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86mincyto-IL18RAP

<400>  109
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Ser Ala 
                260                 265                 270 

Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr 
                275                 280                 285 

Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp 
                290                 295                 300 

Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala 
                305                 310                 315 

Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe Pro 
                320                 325                 330 

Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu Glu 
                335                 340                 345 

Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val Ser 
                350                 355                 360 

Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro Asn 
                365                 370                 375 

Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val Asn 
                380                 385                 390 

Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys Phe 
                395                 400                 405 

Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys Lys 
                410                 415                 420 

Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
                425                 430                 435 

Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met 
                440                 445                 450 

Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile 
                455                 460                 465 

Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr 
                470                 475                 480 

Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                485                 490 

<210>  110
<211>  551
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86-IL18RAP

<400>  110
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val 
1               5                   10                  15  

Met Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala 
                20                  25                  30  

Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser 
                35                  40                  45  

Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln 
                50                  55                  60  

Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe 
                65                  70                  75  

Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser 
                80                  85                  90  

Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
                95                  100                 105 

Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly Met 
                110                 115                 120 

Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
                125                 130                 135 

Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
                140                 145                 150 

Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu 
                155                 160                 165 

Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile 
                170                 175                 180 

Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu 
                185                 190                 195 

Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val 
                200                 205                 210 

Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr 
                215                 220                 225 

Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
                230                 235                 240 

Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr 
                245                 250                 255 

Val Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp 
                260                 265                 270 

Lys Lys Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn 
                275                 280                 285 

Thr Met Glu Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys 
                290                 295                 300 

Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys 
                305                 310                 315 

Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr Cys Phe Ser 
                320                 325                 330 

Ala Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg 
                335                 340                 345 

Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe 
                350                 355                 360 

Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu 
                365                 370                 375 

Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe 
                380                 385                 390 

Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu 
                395                 400                 405 

Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile Val 
                410                 415                 420 

Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro 
                425                 430                 435 

Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val 
                440                 445                 450 

Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys 
                455                 460                 465 

Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
                470                 475                 480 

Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys 
                485                 490                 495 

Ser Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His 
                500                 505                 510 

Met Pro Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg 
                515                 520                 525 

Ile Thr Ser Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu 
                530                 535                 540 

Thr Thr Gly Arg Ser Ser Gln Pro Lys Glu Trp 
                545                 550     

<210>  111
<211>  437
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD86IgV-41BBL-OX40

<400>  111
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
                95                  100                 105 

Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp 
                110                 115                 120 

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
                125                 130                 135 

Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                140                 145                 150 

Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                155                 160                 165 

Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
                170                 175                 180 

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
                185                 190                 195 

Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
                200                 205                 210 

Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
                215                 220                 225 

Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                230                 235                 240 

Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
                245                 250                 255 

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr 
                260                 265                 270 

Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
                275                 280                 285 

Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Ser Leu Asn Gly Gly 
                290                 295                 300 

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                305                 310                 315 

Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser Ala Pro Leu Lys Ile 
                320                 325                 330 

Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala 
                335                 340                 345 

Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp Gln 
                350                 355                 360 

Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
                365                 370                 375 

Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe 
                380                 385                 390 

Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
                395                 400                 405 

Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
                410                 415                 420 

Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu 
                425                 430                 435 

Ala Asn 
        

<210>  112
<211>  613
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK WT

<400>  112
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala Ala 
                215                 220                 225 

Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys Ala Leu Thr 
                230                 235                 240 

Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg Leu Ser 
                245                 250                 255 

Gly Asp Lys Glu Ser Ser Gly Asp Ser Cys Val Ser Thr His Thr 
                260                 265                 270 

Ala Asn Phe Gly Gln Gln Gly Ala Cys Glu Gly Val Leu Leu Leu 
                275                 280                 285 

Thr Leu Glu Glu Lys Thr Phe Pro Glu Asp Met Cys Tyr Pro Asp 
                290                 295                 300 

Gln Gly Gly Val Cys Gln Gly Thr Cys Val Gly Gly Gly Pro Tyr 
                305                 310                 315 

Ala Gln Gly Glu Asp Ala Arg Met Leu Ser Leu Val Ser Lys Thr 
                320                 325                 330 

Glu Ile Glu Glu Asp Ser Phe Arg Gln Met Pro Thr Glu Asp Glu 
                335                 340                 345 

Tyr Met Asp Arg Pro Ser Gln Pro Thr Asp Gln Leu Leu Phe Leu 
                350                 355                 360 

Thr Glu Pro Gly Ser Lys Ser Thr Pro Pro Phe Ser Glu Pro Leu 
                365                 370                 375 

Glu Val Gly Glu Asn Asp Ser Leu Ser Gln Cys Phe Thr Gly Thr 
                380                 385                 390 

Gln Ser Thr Val Gly Ser Glu Ser Cys Asn Cys Thr Glu Pro Leu 
                395                 400                 405 

Cys Arg Thr Asp Trp Thr Pro Met Ser Ser Glu Asn Tyr Leu Gln 
                410                 415                 420 

Lys Glu Val Asp Ser Gly His Cys Pro His Trp Ala Ala Ser Pro 
                425                 430                 435 

Ser Pro Asn Trp Ala Asp Val Cys Thr Gly Cys Arg Asn Pro Pro 
                440                 445                 450 

Gly Glu Asp Cys Glu Pro Leu Val Gly Ser Pro Lys Arg Gly Pro 
                455                 460                 465 

Leu Pro Gln Cys Ala Tyr Gly Met Gly Leu Pro Pro Glu Glu Glu 
                470                 475                 480 

Ala Ser Arg Thr Glu Ala Arg Asp Gln Pro Glu Asp Gly Ala Asp 
                485                 490                 495 

Gly Arg Leu Pro Ser Ser Ala Arg Ala Gly Ala Gly Ser Gly Ser 
                500                 505                 510 

Ser Pro Gly Gly Gln Ser Pro Ala Ser Gly Asn Val Thr Gly Asn 
                515                 520                 525 

Ser Asn Ser Thr Phe Ile Ser Ser Gly Gln Val Met Asn Phe Lys 
                530                 535                 540 

Gly Asp Ile Ile Val Val Tyr Val Ser Gln Thr Ser Gln Glu Gly 
                545                 550                 555 

Ala Ala Ala Ala Ala Glu Pro Met Gly Arg Pro Val Gln Glu Glu 
                560                 565                 570 

Thr Leu Ala Arg Arg Asp Ser Phe Ala Gly Asn Gly Pro Arg Phe 
                575                 580                 585 

Pro Asp Pro Cys Gly Gly Pro Glu Gly Leu Arg Glu Pro Glu Lys 
                590                 595                 600 

Ala Ser Arg Pro Val Gln Glu Gln Gly Gly Ala Lys Ala 
                605                 610             

<210>  113
<211>  230
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANKmincyto

<400>  113
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala Leu Val Ala Ala 
                215                 220                 225 

Ile Ile Phe Gly Val 
                230 

<210>  114
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-OX40

<400>  114
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Val 
                200                 205                 210 

Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
                215                 220                 225 

Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg 
                230                 235                 240 

Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg 
                245                 250                 255 

Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
                260                 265                 270 

Lys Ile 
        

<210>  115
<211>  278
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-41BB

<400>  115
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Ile 
                200                 205                 210 

Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
                215                 220                 225 

Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
                230                 235                 240 

Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255 

Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                260                 265                 270 

Glu Glu Glu Gly Gly Cys Glu Leu 
                275             

<210>  116
<211>  452
<212>  PRT
<213>  Artificial sequence

<220>
<223>  RANK-IL18RAP

<400>  116
Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu 
1               5                   10                  15  

Leu Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile 
                20                  25                  30  

Ala Pro Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg 
                35                  40                  45  

Cys Cys Asn Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys 
                50                  55                  60  

Thr Thr Thr Ser Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu 
                65                  70                  75  

Tyr Leu Asp Ser Trp Asn Glu Glu Asp Lys Cys Leu Leu His Lys 
                80                  85                  90  

Val Cys Asp Thr Gly Lys Ala Leu Val Ala Val Val Ala Gly Asn 
                95                  100                 105 

Ser Thr Thr Pro Arg Arg Cys Ala Cys Thr Ala Gly Tyr His Trp 
                110                 115                 120 

Ser Gln Asp Cys Glu Cys Cys Arg Arg Asn Thr Glu Cys Ala Pro 
                125                 130                 135 

Gly Leu Gly Ala Gln His Pro Leu Gln Leu Asn Lys Asp Thr Val 
                140                 145                 150 

Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser Asp Ala Phe Ser Ser 
                155                 160                 165 

Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr Phe Leu Gly Lys 
                170                 175                 180 

Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala Val Cys Ser 
                185                 190                 195 

Gly Ser Arg Lys Pro Pro Asn Glu Pro His Val Tyr Leu Pro Gly 
                200                 205                 210 

Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu Val 
                215                 220                 225 

Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu 
                230                 235                 240 

Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu 
                245                 250                 255 

Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp 
                260                 265                 270 

Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
                275                 280                 285 

Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly 
                290                 295                 300 

Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val 
                305                 310                 315 

Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly 
                320                 325                 330 

Ile Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe 
                335                 340                 345 

Glu Leu Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu 
                350                 355                 360 

Lys Leu Ile Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser 
                365                 370                 375 

Leu Pro His Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val 
                380                 385                 390 

Thr Trp Arg Gly Leu Lys Ser Val Pro Pro Asn Ser Arg Phe Trp 
                395                 400                 405 

Ala Lys Met Arg Tyr His Met Pro Val Lys Asn Ser Gln Gly Phe 
                410                 415                 420 

Thr Trp Asn Gln Leu Arg Ile Thr Ser Arg Ile Phe Gln Trp Lys 
                425                 430                 435 

Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg Ser Ser Gln Pro Lys 
                440                 445                 450 

Glu Trp 
        

<210>  117
<211>  165
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OX40WT mincyto

<400>  117
Met Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln Gly 
1               5                   10                  15  

Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
                20                  25                  30  

Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys 
                35                  40                  45  

Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr 
                50                  55                  60  

Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val 
                65                  70                  75  

Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr 
                80                  85                  90  

Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
                95                  100                 105 

Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu 
                110                 115                 120 

Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val 
                125                 130                 135 

Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly 
                140                 145                 150 

Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
                155                 160                 165 




<210>  118
<211>  138
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Q8

<400>  118
Met Gly Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Ile Pro 
1               5                   10                  15  

Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly 
                20                  25                  30  

Phe Met Ala Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser 
                35                  40                  45  

Thr Asn Val Ser Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
                50                  55                  60  

Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
                65                  70                  75  

Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                80                  85                  90  

Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                95                  100                 105 

Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                110                 115                 120 

Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
                125                 130                 135 

Pro Val Val 
            

<210>  119
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  eGFP

<400>  119
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
1               5                   10                  15  

Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
                20                  25                  30  

Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
                35                  40                  45  

Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
                50                  55                  60  

Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr 
                65                  70                  75  

Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro 
                80                  85                  90  

Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly 
                95                  100                 105 

Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
                110                 115                 120 

Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly 
                125                 130                 135 

Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
                140                 145                 150 

Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
                155                 160                 165 

Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
                170                 175                 180 

Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
                185                 190                 195 

Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
                200                 205                 210 

Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
                215                 220                 225 

Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
                230                 235                 

<210>  120
<211>  367
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MSCV promoter

<400>  120
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt            50
tgcaaggcat ggaaaataca taactgagaa tagagaagtt cagatcaagg            100
ttaggaacag agagacagca gaatatgggc caaacaggat atctgtggta            150
agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg            200
gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc            250
ccaaggacct gaaaatgacc ctgtgcctta tttgaactaa ccaatcagtt            300
cgcttctcgc ttctgttcgc gcgtttctgc tccccgagct caataaaaga            350
gcccacaacc cctcact                                                367

<210>  121
<211>  155
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70

<400>  121
Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu 
1               5                   10                  15  

Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln 
                20                  25                  30  

Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg 
                35                  40                  45  

Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
                50                  55                  60  

His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala 
                65                  70                  75  

Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
                80                  85                  90  

Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu 
                95                  100                 105 

Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu 
                110                 115                 120 

Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly 
                125                 130                 135 

Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val 
                140                 145                 150 

Gln Trp Val Arg Pro 
                155 

<210>  122
<211>  94
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL2RB ICD

<400>  122
Val Leu His Thr Pro Asp Gln Gly Gln Leu Glu Gln Leu Ser Leu 
1               5                   10                  15  

Tyr Ala Asp Thr Asn Leu Pro Leu Leu Gln Thr Val Lys Asp Arg 
                20                  25                  30  

Glu Leu Val Glu Leu Pro Ser Ile Glu Pro Ala Leu Gly Gly Pro 
                35                  40                  45  

Ser Phe Ser Ser Ser Pro Phe Pro Ser Ser Leu Trp Lys Gln Val 
                50                  55                  60  

Asp Gly Gly His Glu Ser Ser Leu Gln Ser Phe Phe Lys Ser Pro 
                65                  70                  75  

Asp Pro Thr Asn Cys Lys Leu Val Lys Lys Leu Trp Pro Gly Thr 
                80                  85                  90  

Asn Arg Cys Asn 
                

<210>  123
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70-TM

<400>  123
Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
1               5                   10                  15  

Cys Leu Val Val Cys Ile 
                20      

<210>  124
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-13W-OX40

<400>  124
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Trp Pro 
                35                  40                  45  

Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu 
                50                  55                  60  

Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala 
                65                  70                  75  

Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser 
                80                  85                  90  

Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu 
                95                  100                 105 

Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
                110                 115                 120 

Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
                125                 130                 135 

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
                140                 145                 150 

Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
                155                 160                 165 

Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
                170                 175                 180 

Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                185                 190                 195 

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu 
                200                 205                 210 

Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
                215                 220                 225 

Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
                230                 235                 240 

Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
                245                 250                 255 

Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
                260                 265                 270 

Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                275                 280             

<210>  125
<211>  392
<212>  PRT
<213>  Artificial sequence

<220>
<223>  41BBL-OX40-IL2RB

<400>  125
Met Leu Gly Val Leu His Thr Pro Asp Gln Gly Gln Leu Glu Gln 
1               5                   10                  15  

Leu Ser Leu Tyr Ala Asp Thr Asn Leu Pro Leu Leu Gln Thr Val 
                20                  25                  30  

Lys Asp Arg Glu Leu Val Glu Leu Pro Ser Ile Glu Pro Ala Leu 
                35                  40                  45  

Gly Gly Pro Ser Phe Ser Ser Ser Pro Phe Pro Ser Ser Leu Trp 
                50                  55                  60  

Lys Gln Val Asp Gly Gly His Glu Ser Ser Leu Gln Ser Phe Phe 
                65                  70                  75  

Lys Ser Pro Asp Pro Thr Asn Cys Lys Leu Val Lys Lys Leu Trp 
                80                  85                  90  

Pro Gly Thr Asn Arg Cys Asn Gly Ser Gly Arg Asp Gln Arg Leu 
                95                  100                 105 

Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
                110                 115                 120 

Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys 
                125                 130                 135 

Ile Thr Ser Gly Ser Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu 
                140                 145                 150 

Ala Pro Trp Pro Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu 
                155                 160                 165 

Pro Trp Ala Leu Val Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala 
                170                 175                 180 

Ala Ala Cys Ala Val Phe Leu Ala Cys Pro Trp Ala Val Ser Gly 
                185                 190                 195 

Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu 
                200                 205                 210 

Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
                215                 220                 225 

Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
                230                 235                 240 

Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly 
                245                 250                 255 

Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                260                 265                 270 

Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                275                 280                 285 

Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
                290                 295                 300 

Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
                305                 310                 315 

Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
                320                 325                 330 

Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
                335                 340                 345 

Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
                350                 355                 360 

Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
                365                 370                 375 

Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
                380                 385                 390 

Ser Glu 
        

<210>  126
<211>  195
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70

<400>  126
Met Leu Gly Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg 
1               5                   10                  15  

Pro Tyr Gly Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala 
                20                  25                  30  

Gly Leu Val Ile Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln 
                35                  40                  45  

Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala 
                50                  55                  60  

Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu 
                65                  70                  75  

Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
                80                  85                  90  

Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile 
                95                  100                 105 

Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
                110                 115                 120 

Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys 
                125                 130                 135 

Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His 
                140                 145                 150 

Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg 
                155                 160                 165 

Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
                170                 175                 180 

Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                185                 190                 195 




<210>  127
<211>  180
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70mincyto

<400>  127
Met Leu Gly Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala 
1               5                   10                  15  

Gly Leu Val Ile Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln 
                20                  25                  30  

Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala 
                35                  40                  45  

Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu 
                50                  55                  60  

Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
                65                  70                  75  

Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile 
                80                  85                  90  

Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
                95                  100                 105 

Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys 
                110                 115                 120 

Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His 
                125                 130                 135 

Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg 
                140                 145                 150 

Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
                155                 160                 165 

Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                170                 175                 180 




<210>  128
<211>  221
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70mincyto-OX40

<400>  128
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Gly Cys 
                35                  40                  45  

Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
                50                  55                  60  

Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln 
                65                  70                  75  

Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu 
                80                  85                  90  

Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly 
                95                  100                 105 

Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp 
                110                 115                 120 

Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr Met Val His 
                125                 130                 135 

Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg 
                140                 145                 150 

His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser 
                155                 160                 165 

Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr 
                170                 175                 180 

Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu 
                185                 190                 195 

Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp 
                200                 205                 210 

Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
                215                 220     

<210>  129
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD70-41BBL-OX40

<400>  129
Met Leu Gly Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
1               5                   10                  15  

Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
                20                  25                  30  

Asp Ala His Ser Thr Leu Ala Lys Ile Thr Ser Gly Ser Tyr Ala 
                35                  40                  45  

Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro Pro Ala Pro 
                50                  55                  60  

Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val Ala Gly 
                65                  70                  75  

Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe Leu 
                80                  85                  90  

Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu 
                95                  100                 105 

Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln 
                110                 115                 120 

Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg 
                125                 130                 135 

Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
                140                 145                 150 

His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala 
                155                 160                 165 

Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
                170                 175                 180 

Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu 
                185                 190                 195 

Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu 
                200                 205                 210 

Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly 
                215                 220                 225 

Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val 
                230                 235                 240 

Gln Trp Val Arg Pro 
                245 

<210>  130
<211>  915
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 2_Cg1

<400>  130
atggagtggg ccctggccgt gctgctggcc tttctgagcc ctgccagcca            50
gaagtccagc aacctggaag gccggaccaa gagcgtgatc cggcagacag            100
gcagcagcgc cgagatcacc tgtgacctgg ccgagggcag caccggctac            150
atccactggt atctgcacca agaaggcaag gccccccagc ggctgctgta            200
ctacgacagc tacaccagct ccgtggtgct ggaaagcggc atcagccccg            250
ggaagtacga cacctacggc agcacccgga agaacctgcg gatgatcctg            300
cggaacctga tcgagaacga cagcggcgtg tactactgtg ccacatggga            350
cctgcacaag aagctgttcg gcagcggcac aaccctggtg gttacagaca            400
agcagctgga cgccgacgtg agccccaagc ctaccatctt cctgcccagc            450
atcgccgaga ccaagctgca gaaggccggc acctacctgt gcctgctgga            500
aaagttcttc cccgacgtga tcaagatcca ctgggaggaa aagaagagca            550
acaccatcct gggcagccag gaaggcaata ccatgaaaac caacgacacc            600
tacatgaagt tcagctggct gaccgtgccc gagaagagcc tggacaaaga            650
gcacagatgc atcgtccggc acgagaacaa caagaacggc gtggaccagg            700
aaatcatctt cccccccatc aagaccgatg tgatcacaat ggaccccaag            750
gacaactgca gcaaggacgc caacgatacc ctgctgctgc agctgaccaa            800
caccagcgcc tactacatgt atctcctgct gctgctgaag agcgtggtgt            850
acttcgccat catcacctgc tgtctgctgc ggcggaccgc cttctgctgc            900
aacggcgaga agagc                                                  915

<210>  131
<211>  305
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG full length clone 2_Cg1

<400>  131
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Leu His Lys 
                110                 115                 120 

Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys Gln 
                125                 130                 135 

Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser 
                140                 145                 150 

Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu 
                155                 160                 165 

Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu 
                170                 175                 180 

Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met 
                185                 190                 195 

Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro 
                200                 205                 210 

Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu 
                215                 220                 225 

Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile 
                230                 235                 240 

Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys 
                245                 250                 255 

Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala 
                260                 265                 270 

Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe 
                275                 280                 285 

Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys 
                290                 295                 300 

Asn Gly Glu Lys Ser 
                305 

<210>  132
<211>  966
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 3_Cg2

<400>  132
atgagatggg ctctgctggt gctgctggcc tttctgtctc ctgccagcca            50
gaagtccagc aacctggaag gcagaacaaa gagcgtgacc agacagaccg            100
gaagcagcgc cgagatcacc tgtgatctga ccgtgaccaa caccttctac            150
atccactggt atctgcacca agagggcaaa gcccctcagc ggctgctgta            200
ctacgatgtg tctaccgcca gggacgtgct ggaatctgga ctgagccctg            250
gcaagtacta cacccacaca cctcggcggt ggtcctggat tctgagactg            300
cagaacctga tcgagaacga ctccggcgtg tactactgtg ctacctggga            350
cggctactac aagaagctgt tcggcagcgg caccacactg gtggttacag            400
acaagcagct ggacgccgac gtgtccccca agcctaccat cttcctgccc            450
tcaattgctg agacaaagct gcagaaggcc ggcacctacc tgtgcctgct            500
ggaaaagttc ttcccagaca tcatcaagat ccactggcaa gaaaagaagt            550
ccaacaccat cctgggcagc caagaaggca acaccatgaa gaccaacgac            600
acctacatga agttcagctg gctgaccgtg cccgaggagt ccctggacaa            650
agaacaccgg tgcatcgtgc ggcacgagaa caacaagaac ggcatcgacc            700
aagaaatcat cttcccaccc atcaagaccg acgtgacaac agtggacccc            750
aagtacaact acagcaagga cgccaacgac gtgatcacaa tggaccccaa            800
ggacaactgg agcaaggacg ccaacgatac cctgctgctg cagctgacaa            850
acaccagcgc ctactacatg tacttgttgc tgctgctgaa gtccgtggtg            900
tacttcgcca tcatcacatg ctgcctgctg ggccggaccg ccttctgctg            950
caacggcgag aagtcc                                                 966

<210>  133
<211>  322
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG full length clone 3_Cg2

<400>  133
Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Tyr Tyr 
                110                 115                 120 

Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys 
                125                 130                 135 

Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro 
                140                 145                 150 

Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
                155                 160                 165 

Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln 
                170                 175                 180 

Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr 
                185                 190                 195 

Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val 
                200                 205                 210 

Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His 
                215                 220                 225 

Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro 
                230                 235                 240 

Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn Tyr Ser 
                245                 250                 255 

Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp Asn Trp 
                260                 265                 270 

Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr 
                275                 280                 285 

Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val 
                290                 295                 300 

Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Gly Arg Thr Ala Phe 
                305                 310                 315 

Cys Cys Asn Gly Glu Lys Ser 
                320         

<210>  134
<211>  936
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 4_Cg1

<400>  134
atggtgtccc tgctgcacgc cagcaccctg gccgtgctgg gcgccctgtg            50
cgtgtatggc gccggacacc tggaacagcc ccagatcagc agcaccaaga            100
ccctgagcaa gaccgccagg ctggaatgcg tggtgtccgg catcaccatc            150
agcgccacct ccgtgtactg gtacagagag agacccggcg aggtcatcca            200
gttcctggtg tccatcagct acgacggcac cgtgcggaaa gagagcggca            250
tccccagcgg caagttcgag gtggacagaa tccccgagac cagcacctcc            300
accctgacca tccacaacgt ggagaagcag gacatcgcca cctactactg            350
tgctctgtgg gaagtgcacc ccaactacaa gaagctgttc ggcagcggca            400
ccacactggt ggttacagac aagcagctgg acgccgacgt gagccccaag            450
cctaccatct tcctgcccag catcgccgag accaagctgc agaaggccgg            500
cacctacctg tgcctgctgg aaaagttctt ccccgacgtg atcaagatcc            550
actgggagga aaagaagagc aacaccatcc tgggcagcca ggaaggcaat            600
accatgaaaa ccaacgacac ctacatgaag ttcagctggc tgaccgtgcc            650
cgagaagagc ctggacaaag agcacagatg catcgtccgg cacgagaaca            700
acaagaacgg cgtggaccag gaaatcatct tcccccccat caagaccgat            750
gtgatcacaa tggaccccaa ggacaactgc agcaaggacg ccaacgatac            800
cctgctgctg cagctgacca acaccagcgc ctactacatg tatctcctgc            850
tgctgctgaa gagcgtggtg tacttcgcca tcatcacctg ctgtctgctg            900
cggcggaccg ccttctgctg caacggcgag aagagc                           936

<210>  135
<211>  312
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG full length clone 4_Cg1

<400>  135
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala 
1               5                   10                  15  

Leu Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser 
                20                  25                  30  

Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val 
                35                  40                  45  

Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
                50                  55                  60  

Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp 
                65                  70                  75  

Gly Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu 
                80                  85                  90  

Val Asp Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His 
                95                  100                 105 

Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp 
                110                 115                 120 

Glu Val His Pro Asn Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr 
                125                 130                 135 

Leu Val Val Thr Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys 
                140                 145                 150 

Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys 
                155                 160                 165 

Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val 
                170                 175                 180 

Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn Thr Ile Leu Gly 
                185                 190                 195 

Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys 
                200                 205                 210 

Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His 
                215                 220                 225 

Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln 
                230                 235                 240 

Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp 
                245                 250                 255 

Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu 
                260                 265                 270 

Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu 
                275                 280                 285 

Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu 
                290                 295                 300 

Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                305                 310         

<210>  136
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  clone 5 TRG CDR3

<400>  136
Cys Ala Leu Trp Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val 
1               5                   10                  15  

Phe 
    

<210>  137
<211>  990
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised clone 5_Cg2

<400>  137
atggtgtccc tgctgcacgc cagcaccctg gccgtgctgg gcgccctgtg            50
cgtgtatggc gccggacacc tggaacagcc ccagatcagc agcaccaaga            100
ccctgagcaa gaccgccagg ctggaatgcg tggtgtccgg catcaccatc            150
agcgccacct ccgtgtactg gtacagagag agacccggcg aggtcatcca            200
gttcctggtg tccatcagct acgacggcac cgtgcggaaa gagagcggca            250
tccccagcgg caagttcgag gtggacagaa tccccgagac cagcacctcc            300
accctgacca tccacaacgt ggagaagcag gacatcgcca cctactactg            350
cgccctgtgg gagatccagg aactgggcaa gaaaatcaag gtgttcggcc            400
ctggcaccaa gctgatcatc accgacaagc agctggacgc cgacgtgtcc            450
cccaagccta ccatcttcct gccctcaatt gctgagacaa agctgcagaa            500
ggccggcacc tacctgtgcc tgctggaaaa gttcttccca gacatcatca            550
agatccactg gcaagaaaag aagtccaaca ccatcctggg cagccaagaa            600
ggcaacacca tgaagaccaa cgacacctac atgaagttca gctggctgac            650
cgtgcccgag gagtccctgg acaaagaaca ccggtgcatc gtgcggcacg            700
agaacaacaa gaacggcatc gaccaagaaa tcatcttccc acccatcaag            750
accgacgtga caacagtgga ccccaagtac aactacagca aggacgccaa            800
cgacgtgatc acaatggacc ccaaggacaa ctggagcaag gacgccaacg            850
ataccctgct gctgcagctg acaaacacca gcgcctacta catgtacttg            900
ttgctgctgc tgaagtccgt ggtgtacttc gccatcatca catgctgcct            950
gctgggccgg accgccttct gctgcaacgg cgagaagtcc                       990

<210>  138
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG full length clone 5_Cg2

<400>  138
Met Val Ser Leu Leu His Ala Ser Thr Leu Ala Val Leu Gly Ala 
1               5                   10                  15  

Leu Cys Val Tyr Gly Ala Gly His Leu Glu Gln Pro Gln Ile Ser 
                20                  25                  30  

Ser Thr Lys Thr Leu Ser Lys Thr Ala Arg Leu Glu Cys Val Val 
                35                  40                  45  

Ser Gly Ile Thr Ile Ser Ala Thr Ser Val Tyr Trp Tyr Arg Glu 
                50                  55                  60  

Arg Pro Gly Glu Val Ile Gln Phe Leu Val Ser Ile Ser Tyr Asp 
                65                  70                  75  

Gly Thr Val Arg Lys Glu Ser Gly Ile Pro Ser Gly Lys Phe Glu 
                80                  85                  90  

Val Asp Arg Ile Pro Glu Thr Ser Thr Ser Thr Leu Thr Ile His 
                95                  100                 105 

Asn Val Glu Lys Gln Asp Ile Ala Thr Tyr Tyr Cys Ala Leu Trp 
                110                 115                 120 

Glu Ile Gln Glu Leu Gly Lys Lys Ile Lys Val Phe Gly Pro Gly 
                125                 130                 135 

Thr Lys Leu Ile Ile Thr Asp Lys Gln Leu Asp Ala Asp Val Ser 
                140                 145                 150 

Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu 
                155                 160                 165 

Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro 
                170                 175                 180 

Asp Ile Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile 
                185                 190                 195 

Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr 
                200                 205                 210 

Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys 
                215                 220                 225 

Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Ile 
                230                 235                 240 

Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Thr Thr 
                245                 250                 255 

Val Asp Pro Lys Tyr Asn Tyr Ser Lys Asp Ala Asn Asp Val Ile 
                260                 265                 270 

Thr Met Asp Pro Lys Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr 
                275                 280                 285 

Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu 
                290                 295                 300 

Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys 
                305                 310                 315 

Cys Leu Leu Gly Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                320                 325                 330 




<210>  139
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C132 TRG CDR3

<400>  139
Cys Ala Thr Trp Asp Gly Phe Tyr Tyr Lys Lys Leu Phe 
1               5                   10              

<210>  140
<211>  969
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRG codon optimised C132_Cg2

<400>  140
atggagtggg ccctggccgt gctgctggcc tttctgagcc ctgccagcca            50
gaagtccagc aacctggaag gccggaccaa gagcgtgatc cggcagacag            100
gcagcagcgc cgagatcacc tgtgacctgg ccgagggcag caccggctac            150
atccactggt atctgcacca agaaggcaag gccccccagc ggctgctgta            200
ctacgacagc tacaccagct ccgtggtgct ggaaagcggc atcagccccg            250
ggaagtacga cacctacggc agcacccgga agaacctgcg gatgatcctg            300
cggaacctga tcgagaacga cagcggcgtg tactactgcg ccacctggga            350
cggcttctac tacaagaagc tgttcggcag cggcaccacc ctggtggtga            400
cagacaagca gctggacgcc gacgtgtccc ccaagcctac catcttcctg            450
ccctcaattg ctgagacaaa gctgcagaag gccggcacct acctgtgcct            500
gctggaaaag ttcttcccag acatcatcaa gatccactgg caagaaaaga            550
agtccaacac catcctgggc agccaagaag gcaacaccat gaagaccaac            600
gacacctaca tgaagttcag ctggctgacc gtgcccgagg agtccctgga            650
caaagaacac cggtgcatcg tgcggcacga gaacaacaag aacggcatcg            700
accaagaaat catcttccca cccatcaaga ccgacgtgac aacagtggac            750
cccaagtaca actacagcaa ggacgccaac gacgtgatca caatggaccc            800
caaggacaac tggagcaagg acgccaacga taccctgctg ctgcagctga            850
caaacaccag cgcctactac atgtacttgt tgctgctgct gaagtccgtg            900
gtgtacttcg ccatcatcac atgctgcctg ctgggccgga ccgccttctg            950
ctgcaacggc gagaagtcc                                              969

<210>  141
<211>  323
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRG full length C132_Cg2

<400>  141
Met Glu Trp Ala Leu Ala Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu 
                35                  40                  45  

Gly Ser Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val 
                65                  70                  75  

Val Leu Glu Ser Gly Ile Ser Pro Gly Lys Tyr Asp Thr Tyr Gly 
                80                  85                  90  

Ser Thr Arg Lys Asn Leu Arg Met Ile Leu Arg Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Phe Tyr 
                110                 115                 120 

Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp 
                125                 130                 135 

Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu 
                140                 145                 150 

Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu 
                155                 160                 165 

Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp 
                170                 175                 180 

Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn 
                185                 190                 195 

Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr 
                200                 205                 210 

Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg 
                215                 220                 225 

His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe Pro 
                230                 235                 240 

Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn Tyr 
                245                 250                 255 

Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp Asn 
                260                 265                 270 

Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn 
                275                 280                 285 

Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val 
                290                 295                 300 

Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Gly Arg Thr Ala 
                305                 310                 315 

Phe Cys Cys Asn Gly Glu Lys Ser 
                320             

<210>  142
<211>  250
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR clone 3  TRD_soluble

<400>  142
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys 
1               5                   10                  15  

Leu Glu Phe Ser Met Ala Ser Ala Ala Gln Lys Val Thr Gln Ala 
                20                  25                  30  

Gln Ser Ser Val Ser Met Pro Val Arg Lys Ala Val Thr Leu Asn 
                35                  40                  45  

Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr 
                50                  55                  60  

Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu Ile Arg Gln Gly 
                65                  70                  75  

Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val Asn Phe 
                80                  85                  90  

Lys Lys Ala Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu Gln 
                95                  100                 105 

Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Phe Pro 
                110                 115                 120 

Tyr Trp Gly Ile Pro Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg 
                125                 130                 135 

Val Thr Val Glu Pro Arg Ser Gln Pro His Thr Lys Pro Ser Val 
                140                 145                 150 

Phe Val Met Lys Asn Gly Thr Asn Val Ala Cys Leu Val Lys Glu 
                155                 160                 165 

Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu Val Ser Ser Lys Lys 
                170                 175                 180 

Ile Thr Glu Phe Asp Pro Ala Ile Val Ile Ser Pro Ser Gly Lys 
                185                 190                 195 

Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu Asp Ser Asn Ser Val 
                200                 205                 210 

Thr Cys Ser Val Gln His Asp Asn Lys Thr Val His Ser Thr Asp 
                215                 220                 225 

Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu 
                230                 235                 240 

Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser 
                245                 250 

<210>  143
<211>  258
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR clone 3  TRG_Cg1_soluble

<400>  143
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys 
1               5                   10                  15  

Leu Glu Phe Ser Met Ala Arg Thr Ser Ser Asn Leu Glu Gly Arg 
                20                  25                  30  

Thr Lys Ser Val Thr Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr 
                35                  40                  45  

Cys Asp Leu Thr Val Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu 
                50                  55                  60  

His Gln Glu Gly Lys Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val 
                65                  70                  75  

Ser Thr Ala Arg Asp Val Leu Glu Ser Gly Leu Ser Pro Gly Lys 
                80                  85                  90  

Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser Trp Ile Leu Arg Leu 
                95                  100                 105 

Gln Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr 
                110                 115                 120 

Trp Asp Gly Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu 
                125                 130                 135 

Val Val Thr Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro 
                140                 145                 150 

Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala 
                155                 160                 165 

Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val Ile 
                170                 175                 180 

Lys Ile His Trp Glu Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser 
                185                 190                 195 

Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe 
                200                 205                 210 

Ser Trp Leu Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg 
                215                 220                 225 

Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu 
                230                 235                 240 

Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro 
                245                 250                 255 

Lys Asp Asn 
            

<210>  144
<211>  274
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR clone 3  TRG_Cg2_soluble

<400>  144
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys 
1               5                   10                  15  

Leu Glu Phe Ser Met Ala Arg Thr Ser Ser Asn Leu Glu Gly Arg 
                20                  25                  30  

Thr Lys Ser Val Thr Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr 
                35                  40                  45  

Cys Asp Leu Thr Val Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu 
                50                  55                  60  

His Gln Glu Gly Lys Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val 
                65                  70                  75  

Ser Thr Ala Arg Asp Val Leu Glu Ser Gly Leu Ser Pro Gly Lys 
                80                  85                  90  

Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser Trp Ile Leu Arg Leu 
                95                  100                 105 

Gln Asn Leu Ile Glu Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr 
                110                 115                 120 

Trp Asp Gly Tyr Tyr Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu 
                125                 130                 135 

Val Val Thr Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro 
                140                 145                 150 

Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala 
                155                 160                 165 

Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile 
                170                 175                 180 

Lys Ile His Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser 
                185                 190                 195 

Gln Glu Gly Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe 
                200                 205                 210 

Ser Trp Leu Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg 
                215                 220                 225 

Cys Ile Val Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu 
                230                 235                 240 

Ile Ile Phe Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro 
                245                 250                 255 

Lys Tyr Asn Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp 
                260                 265                 270 

Pro Lys Asp Asn 
                

<210>  145
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  145
Arg Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  

Gly Ser 
        

<210>  146
<211>  245
<212>  PRT
<213>  Artificial sequence

<220>
<223>  scFv CD3 -binding

<400>  146
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15  

Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                20                  25                  30  

Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                35                  40                  45  

Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr 
                50                  55                  60  

Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                65                  70                  75  

Lys Asn Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
                80                  85                  90  

Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys 
                95                  100                 105 

Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Gly 
                110                 115                 120 

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
                125                 130                 135 

Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                140                 145                 150 

Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
                155                 160                 165 

Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp 
                170                 175                 180 

Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
                185                 190                 195 

Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                200                 205                 210 

Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
                215                 220                 225 

Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
                230                 235                 240 

Arg Val Asp Gly Ser 
                245 

<210>  147
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker

<400>  147
Gly Ser Gly 
1           

<210>  148
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AVI-TAG

<400>  148
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  

Gly Ser Gly Gly Gly Gly 
                20      

<210>  149
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  His-TAG

<400>  149
His His His His His His His 
1               5           

<210>  150
<211>  13120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pHCAG-L2EOP

<400>  150
ggggaggagc ggggggagga gcggggggag gagcgggggg aggagcggcc            50
agaccccgaa aacgggcccc ccccaaaaca caccccccgg gggtcgcgcg            100
cggcccttta aagcggcggc ggcgggcagc ccgggccccc cgcggccgag            150
actagcgagt tagacaggca agcactactc gcctctgcac gcacatgctt            200
gcctgtcaaa ctctaccacc ccggcacgct ctctgtctcc atggcccgcc            250
gccgccgcca tcgcggcccc cgccgccccc ggccgcccgg gcccacgggc            300
gccgtcccaa ccgcacagtc ccaggtaacg actctaggaa ttaattcttg            350
aagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga            400
taataatggt ttcttagggt cgaccggtcg accggtcgac cggtcgacca            450
ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt            500
ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa            550
tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt            600
gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca            650
cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac            700
gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt            750
tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct            800
atgtggcgcg gtattatccc gtgttgacgc cgggcaagag caactcggtc            850
gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca            900
gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc            950
cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg            1000
gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta            1050
actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga            1100
cgagcgtgac accacgatgc ctgcagcaat ggcaacaacg ttgcgcaaac            1150
tattaactgg cgaactactt actctagctt cccggcaaca attaatagac            1200
tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc            1250
ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc            1300
gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta            1350
gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca            1400
gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc            1450
aagtttactc atatatactt tagattgatt taaaacttca tttttaattt            1500
aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc            1550
ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca            1600
aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa            1650
acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct            1700
accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa            1750
atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct            1800
gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc            1850
tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt            1900
taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag            1950
cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga            2000
gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc            2050
cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg            2100
ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact            2150
tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa            2200
acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt            2250
gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat            2300
taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc            2350
gcagcgagtc agtgagcgag gaagcggaag agcgcctgat gcggtatttt            2400
ctccttacgc atctgtgcgg tatttcacac cgcataggtc gaccggtcga            2450
ccggtcgacc ggtcgaccgg tcgaccatgg tgcactctca gtacaatctg            2500
ctctgatgcc gcatagttaa gccagtatac actccgctat cgctacgtga            2550
ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct            2600
gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc            2650
tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc            2700
gaggcagcat gaattattcc attatgcacg accccgcccc gacgccggca            2750
cgccgggggc ccgtggccgc ggcccgttgg tcgaaccccc ggccccgccc            2800
atccgcgcca tctgccatgg gcggggcgcg agggcgggtg ggtccgcgcc            2850
ccgccccgca tggcatctca ttaccgcccg atccggcggt ttccgcttcc            2900
gttccgcatg ctaacgagga acaggcaggg ggcggggccc gggccccgac            2950
ttcccggttc ggcggtaatg agatacgagc cccgcgcgcc cgttggccgt            3000
ccccgggccc cccggtcccg cccgccggac gccgggacca acgggacggc            3050
gggcggccca agggccgccc gccttgccgc ccccccattg gccggcgggc            3100
gggaccgccc caagggggcg gggccgccgg gtaaaagaag tgagaacgcg            3150
aagcgttcgc acttcgtccc aatatatata tattattagg gcgaagtgcg            3200
agcactggcg ccgtgcccga ctccgcgccg gccccggggg cgggcccggg            3250
cggcgggggg cgggtctctc cggcgcacat aaaggcccgg cgcgaccgac            3300
gcccgcagac ggcgccggcc acgaacgacg ggagcggctg cggagcacgc            3350
ggaccgggag cgggagtcgc agagggccgt cggagcggac ggcgtcggca            3400
tcgcgacgcc ccggctcggg atcgggatcg catcggaaag ggacacgcgg            3450
acgcgggggg gaaagacccg cccaccccac ccacgaaaca caggggacgc            3500
accccggggg cctccgacga cagaaaccca ccggtccgcc ttttttgcac            3550
gggtaagcac cttgggtggg cggaggaggg ggggacgcgg gggcggagga            3600
ggggggacgc gggggcggag gaggggggac gcgggggcgg aggagggggg            3650
acgcgggggc ggaggagggg ggacgcgggg gcggaggagg gggctcaccc            3700
gcgttcgtgc cttcccgcag gaggaacgtc ctcgtcgata agctgatcca            3750
tcgccaccat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc            3800
atcctggtcg agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc            3850
cggcgagggc gagggcgatg ccacctacgg caagctgacc ctgaagttca            3900
tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc            3950
ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca            4000
gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca            4050
ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag            4100
ttcgagggcg acaccctggt gaaccgcatc gagctgaagg gcatcgactt            4150
caaggaggac ggcaacatcc tggggcacaa gctggagtac aactacaaca            4200
gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg            4250
aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga            4300
ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg            4350
acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag            4400
aagcgcgatc acatggtcct gctggagttc gtgaccgccg ccgggatcac            4450
tctcggcatg gacgagctgt acaagtaaag cggccaactt gtttattgca            4500
gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa            4550
agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg            4600
tatcttatca tgtctggatc ggtttgaaga tctcccgatc ccctatggtg            4650
cactctcagt acaatctgct ctgatgccgc atagttaagc cagtatctgc            4700
tccctgcttg tgtgttggag gtcgctgagt agtgcgcgag caaaatttaa            4750
gctacaacaa ggcaaggctt gaccgacaat tgcatgaaga atctgcttag            4800
ggttaggcgt tttgcgctgc ttcgcgatgt acgggccaga tatacgcgtt            4850
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta            4900
gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg            4950
cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga            5000
cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg            5050
gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca            5100
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct            5150
ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac            5200
atctacgtat tagtcatcgc tattaccatg gtcgaggtga gccccacgtt            5250
ctgcttcact ctccccatct cccccccctc cccaccccca attttgtatt            5300
tatttatttt ttaattattt tgtgcagcga tgggggcggg gggggggggg            5350
gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag            5400
gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc            5450
cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg            5500
cggcgggcgg gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc            5550
cgccgcctcg cgccgcccgc cccggctctg actgaccgcg ttactcccac            5600
aggtgagcgg gcgggacggc ccttctcctc cgggctgtaa ttagcgcttg            5650
gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa gccttgaggg            5700
gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg            5750
tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc            5800
tgtgagcgct gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg            5850
cgaggggagc gcggccgggg gcggtgcccc gcggtgcggg gggggctgcg            5900
aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg            5950
ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc cccctccccg            6000
agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg            6050
gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg            6100
ggcggggcgg ggccgcctcg ggccggggag ggctcggggg aggggcgcgg            6150
cggcccccgg agcgccggcg gctgtcgagg cgcggcgagc cgcagccatt            6200
gccttttatg gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa            6250
atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc cctctagcgg            6300
gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg            6350
gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg            6400
ggctgtccgc ggggggacgg ctgccttcgg gggggacggg gcagggcggg            6450
gttcggcttc tggcgtgtga ccggcggctc tagcgtttaa acttaagctt            6500
ggtaccgagc tcggatccac tagtccagtg tggtggaatt ctgcagatat            6550
ccagcacagt ggcggccgct cgagccacca tggaagacgc caaaaacata            6600
aagaaaggcc cggcgccatt ctatccgctg gaagatggaa ccgctggaga            6650
gcaactgcat aaggctatga agagatacgc cctggttcct ggaacaattg            6700
cttttacaga tgcacatatc gaggtggaca tcacttacgc tgagtacttc            6750
gaaatgtccg ttcggttggc agaagctatg aaacgatatg ggctgaatac            6800
aaatcacaga atcgtcgtat gcagtgaaaa ctctcttcaa ttctttatgc            6850
cggtgttggg cgcgttattt atcggagttg cagttgcgcc cgcgaacgac            6900
atttataatg aacgtgaatt gctcaacagt atgggcattt cgcagcctac            6950
cgtggtgttc gtttccaaaa aggggttgca aaaaattttg aacgtgcaaa            7000
aaaagctccc aatcatccaa aaaattatta tcatggattc taaaacggat            7050
taccagggat ttcagtcgat gtacacgttc gtcacatctc atctacctcc            7100
cggttttaat gaatacgatt ttgtgccaga gtccttcgat agggacaaga            7150
caattgcact gatcatgaac tcctctggat ctactggtct gcctaaaggt            7200
gtcgctctgc ctcatagaac tgcctgcgtg agattctcgc atgccagaga            7250
tcctattttt ggcaatcaaa tcattccgga tactgcgatt ttaagtgttg            7300
ttccattcca tcacggtttt ggaatgttta ctacactcgg atatttgata            7350
tgtggatttc gagtcgtctt aatgtataga tttgaagaag agctgtttct            7400
gaggagcctt caggattaca agattcaaag tgcgctgctg gtgccaaccc            7450
tattctcctt cttcgccaaa agcactctga ttgacaaata cgatttatct            7500
aatttacacg aaattgcttc tggtggcgct cccctctcta aggaagtcgg            7550
ggaagcggtt gccaagaggt tccatctgcc aggtatcagg caaggatatg            7600
ggctcactga gactacatca gctattctga ttacacccga gggggatgat            7650
aaaccgggcg cggtcggtaa agttgttcca ttttttgaag cgaaggttgt            7700
ggatctggat accgggaaaa cgctgggcgt taatcaaaga ggcgaactgt            7750
gtgtgagagg tcctatgatt atgtccggtt atgtaaacaa tccggaagcg            7800
accaacgcct tgattgacaa ggatggatgg ctacattctg gagacatagc            7850
ttactgggac gaagacgaac acttcttcat cgttgaccgc ctgaagtctc            7900
tgattaagta caaaggctat caggtggctc ccgctgaatt ggaatccatc            7950
ttgctccaac accccaacat cttcgacgca ggtgtcgcag gtcttcccga            8000
cgatgacgcc ggtgaacttc ccgccgccgt tgttgttttg gagcacggaa            8050
agacgatgac ggaaaaagag atcgtggatt acgtcgccag tcaagtaaca            8100
accgcgaaaa agttgcgcgg aggagttgtg tttgtggacg aagtaccgaa            8150
aggtcttacc ggaaaactcg acgcaagaaa aatcagagag atcctcataa            8200
aggccaagaa gggcggaaag atcgccgtgg tgaaacagac tttgaatttt            8250
gaccttctca agttggcggg agacgtcgag tccaaccctg ggcccatcat            8300
gtctgacgag gggccaggta caggacctgg aaatggccta ggagagaagg            8350
gagacacatc tggaccagaa ggctccggcg gcagtggacc tcaaagaaga            8400
gggggtgata accatggacg aggacgggga agaggacgag gacgaggagg            8450
cggaagacca ggagccccgg gcggctcagg atcagggcca agacatagag            8500
atggtgtccg gagaccccaa aaacgtccaa gttgcattgg ctgcaaaggg            8550
acccacggtg gaacaggagc aggagcagga gcgggagggg caggagcagg            8600
aggtggaggc cggggtcgag gaggcagtgg aggccggggt cgaggaggta            8650
gtggaggccg gggtcgagga ggtagtggag gccgccgggg tagaggacgt            8700
gaaagagcca gggggggaag tcgtgaaaga gccaggggga gaggtcgtgg            8750
acgtggagaa aagaggccca ggagtcccag tagtcagtca tcatcatccg            8800
ggtctccacc gcgcaggccc cctccaggta gaaggccatt tttccaccct            8850
gtaggggaag ccgattattt tgaataccac caagaaggtg gcccagatgg            8900
tgagcctgac gtgcccccgg gagcgataga gcagggcccc gcagatgacc            8950
caggagaagg cccaagcact ggaccccggg gtcagggtga tggaggcagg            9000
cgcaaaaaag gagggtggtt tggaaagcat cgtggtcaag gaggttccaa            9050
cccgaaattt gagaacattg cagaaggttt aagagctctc ctggctagga            9100
gtcacgtaga aaggactacc gacgaaggaa cttgggtcgc cggtgtgttc            9150
gtatatggag gtagtaagac ctccctttac aacctaaggc gaggaactgc            9200
ccttgctatt ccacaatgtc gtcttacacc attgagtcgt ctcccctttg            9250
gaatggcccc tggacccggc ccacaacctg gcccgctaag ggagtccatt            9300
gtctgttatt tcatggtctt tttacaaact catatatttg ctgaggtttt            9350
gaaggatgcg attaaggacc ttgttatgac aaagcccgct cctacctgca            9400
atatcagggt gactgtgtgc agctttgacg atggagtaga tttgcctccc            9450
tggtttccac ctatggtgga aggggctgcc gcggagggtg atgacggaga            9500
tgacggagat gaaggaggtg atggagatga gggtgaggaa gggcaggagt            9550
gatgtaactt gttaggagac gccctcaatc gtattaaaag ccgtgtattc            9600
ccccgcacta aagaataaat ccccagtaga catcatgcgt gctgttggtg            9650
tatttctggc catctgtctt gtcaccattt tcgtcctccc aacatggggc            9700
aattgggcat acccatgttg tcacgtcact cagctccgcg ctcaacacct            9750
tctcgcgttg gaaaacatta gcgacattta cctggtgagc aatcagacat            9800
gcgacggctt tagcctggcc tccttaaatt cacctaagaa tgggagcaac            9850
cagcaggaaa aggacaagca gcgaaaattc acgccccctt gggaggtggc            9900
ggcatatgca aaggatagca ctcccactct actactgggt atcatatgct            9950
gactgtatat gcatgaggat agcatatgct acccggatac agattaggat            10000
agcatatact acccagatat agattaggat agcatatgct acccagatat            10050
agattaggat agcctatgct acccagatat aaattaggat agcatatact            10100
acccagatat agattaggat agcatatgct acccagatat agattaggat            10150
agcctatgct acccagatat agattaggat agcatatgct acccagatat            10200
agattaggat agcatatgct atccagatat ttgggtagta tatgctaccc            10250
agatataaat taggatagca tatactaccc taatctctat taggatagca            10300
tatgctaccc ggatacagat taggatagca tatactaccc agatatagat            10350
taggatagca tatgctaccc agatatagat taggatagcc tatgctaccc            10400
agatataaat taggatagca tatactaccc agatatagat taggatagca            10450
tatgctaccc agatatagat taggatagcc tatgctaccc agatatagat            10500
taggatagca tatgctatcc agatatttgg gtagtatatg ctacccatgg            10550
caacattagc ccaccgtgct ctcagcgacc tcgtgaatat gaggaccaac            10600
aaccctgtgc ttggcgctca ggcgcaagtg tgtgtaattt gtcctccaga            10650
tcgcagcaat cgcgccccta tcttggcccg cccacctact tatgcaggta            10700
ttccccgggg tgccattagt ggttttgtgg gcaagtggtt tgaccgcagt            10750
ggttagcggg gttacaatca gccaagttat tacaccctta ttttacagtc            10800
caaaaccgca gggcggcgtg tgggggctga cgcgtgcccc cactccacaa            10850
tttcaaaaaa aagagtggcc acttgtcttt gtttatgggc cccattggcg            10900
tggagccccg tttaattttc gggggtgtta gagacaacca gtggagtccg            10950
ctgctgtcgg cgtccactct ctttcccctt gttacaaata gagtgtaaca            11000
acatggttca cctgtcttgg tccctgcctg ggacacatct taataacccc            11050
agtatcatat tgcactagga ttatgtgttg cccatagcca taaattcgtg            11100
tgagatggac atccagtctt tacggcttgt ccccacccca tggatttcta            11150
ttgttaaaga tattcagaat gtttcattcc tacactagta tttattgccc            11200
aaggggtttg tgagggttat attggtgtca tagcacaatg ccaccactga            11250
accccccgtc caaattttat tctgggggcg tcacctgaaa ccttgttttc            11300
gagcacctca catacacctt actgttcaca actcagcagt tattctatta            11350
gctaaacgaa ggagaatgaa gaagcaggcg aagattcagg agagttcact            11400
gcccgctcct tgatcttcag ccactgccct tgtgactaaa atggttcact            11450
accctcgtgg aatcctgacc ccatgtaaat aaaaccgtga cagctcatgg            11500
ggtgggagat atcgctgttc cttaggaccc ttttactaac cctaattcga            11550
tagcatatgc ttcccgttgg gtaacatatg ctattgaatt agggttagtc            11600
tggatagtat atactactac ccgggaagca tatgctaccc gtttagggtt            11650
aacaaggggg ccttataaac actattgcta atgccctctt gagggtccgc            11700
ttatcggtag ctacacaggc ccctctgatt gacgttggtg tagcctcccg            11750
tagtcttcct gggcccctgg gaggtacatg tcccccagca ttggtgtaag            11800
agcttcagcc aagagttaca cataaagggc tagctcgaca tgataagata            11850
cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct            11900
ttatttgtga aatttgtgat gctattgctt tatttgtgaa atttgtgatg            11950
ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac            12000
aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt            12050
tttttaaagc aagtaaaacc tctacaaatg tggtagatcc atttaaatgt            12100
taattaaatt ccagctgagc gccggtcgct accattacca gttggtctgg            12150
tgtcaaaaat aataataacc gggcaggcca tgtctgcccg tatttcgcgt            12200
aaggaaatcc attatgtact atttaaaaaa cacaaacttt tggatgttcg            12250
gtttattctt tttcttttac ttttttatca tgggagccta cttcccgttt            12300
ttcccgattt ggctacatga catcaaccat atcagcaaaa gtgatacggg            12350
tattattttt gccgctattt ctctgttctc gctattattc caaccgctgt            12400
ttggtctgct ttctgacaaa ctcggaactt gtttattgca gcttataatg            12450
gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt            12500
tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca            12550
tgtctggatc tctgacctga gattggcggc actgaggtag agatgcccga            12600
acccccccga gggagcgcgg gacgcggccg gggagggctg gggccgggga            12650
gggctggggc cggggagggc tggggccggg gagggctggg gccggggagg            12700
gctggggccg gggagggctg gggctgggga ggggcggtgg tgtgtagcag            12750
gagcggtgtg ttgcgccggg gtacgtctgg aggagcggga ggtgcgcggt            12800
gacgtgtgga tgaggaacag gagttgttgc gcggtgagtt gtcgctgtga            12850
gttgtgttgt tgggcaggtg tggtggatga cgtgacgtgt gacgtgcgga            12900
gtgcgccgtg ctctgttggt ttcacctgtg gcagcccggg ccccccgcgg            12950
gcgcgcgcgc gcgcaaaaaa ggcgggcggc ggtccgggcg gcgtgcgcgc            13000
gcgcggcggg cgtggggggc ggggccgcgg gagcgggggg aggagcgggg            13050
ggaggagcgg ggggaggagc ggggggagga gcggggggag gagcgggggg            13100
aggagcgggg ggaggagcgg                                             13120

<210>  151
<211>  516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cg1

<400>  151
gacaagcagc tggacgccga cgtgagcccc aagcctacca tcttcctgcc            50
cagcatcgcc gagaccaagc tgcagaaggc cggcacctac ctgtgcctgc            100
tggaaaagtt cttccccgac gtgatcaaga tccactggga ggaaaagaag            150
agcaacacca tcctgggcag ccaggaaggc aataccatga aaaccaacga            200
cacctacatg aagttcagct ggctgaccgt gcccgagaag agcctggaca            250
aagagcacag atgcatcgtc cggcacgaga acaacaagaa cggcgtggac            300
caggaaatca tcttcccccc catcaagacc gatgtgatca caatggaccc            350
caaggacaac tgcagcaagg acgccaacga taccctgctg ctgcagctga            400
ccaacaccag cgcctactac atgtatctcc tgctgctgct gaagagcgtg            450
gtgtacttcg ccatcatcac ctgctgtctg ctgcggcgga ccgccttctg            500
ctgcaacggc gagaag                                                 516

<210>  152
<211>  173
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cg1

<400>  152
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe 
1               5                   10                  15  

Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                20                  25                  30  

Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His 
                35                  40                  45  

Trp Glu Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly 
                50                  55                  60  

Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                65                  70                  75  

Thr Val Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val 
                80                  85                  90  

Arg His Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe 
                95                  100                 105 

Pro Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn 
                110                 115                 120 

Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn 
                125                 130                 135 

Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val 
                140                 145                 150 

Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala 
                155                 160                 165 

Phe Cys Cys Asn Gly Glu Lys Ser 
                170             

<210>  153
<211>  225
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR clone 3  TRD_soluble_no signal pept

<400>  153
Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg Lys 
1               5                   10                  15  

Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr 
                20                  25                  30  

Tyr Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe 
                35                  40                  45  

Leu Ile Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg 
                50                  55                  60  

Tyr Ser Val Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu Thr 
                65                  70                  75  

Ile Ser Ala Leu Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala 
                80                  85                  90  

Leu Gly Glu Phe Pro Tyr Trp Gly Ile Pro Asp Lys Leu Ile Phe 
                95                  100                 105 

Gly Lys Gly Thr Arg Val Thr Val Glu Pro Arg Ser Gln Pro His 
                110                 115                 120 

Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr Asn Val Ala 
                125                 130                 135 

Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile Asn Leu 
                140                 145                 150 

Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val Ile 
                155                 160                 165 

Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu 
                170                 175                 180 

Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr 
                185                 190                 195 

Val His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His 
                200                 205                 210 

Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser 
                215                 220                 225 




<210>  154
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR clone 3  TRG_Cg1_soluble_no signal pept

<400>  154
Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg Gln Thr Gly Ser 
1               5                   10                  15  

Ser Ala Glu Ile Thr Cys Asp Leu Thr Val Thr Asn Thr Phe Tyr 
                20                  25                  30  

Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu 
                35                  40                  45  

Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp Val Leu Glu Ser Gly 
                50                  55                  60  

Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser 
                65                  70                  75  

Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu Asn Asp Ser Gly Val 
                80                  85                  90  

Tyr Tyr Cys Ala Thr Trp Asp Gly Tyr Tyr Lys Lys Leu Phe Gly 
                95                  100                 105 

Ser Gly Thr Thr Leu Val Val Thr Asp Lys Gln Leu Asp Ala Asp 
                110                 115                 120 

Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr 
                125                 130                 135 

Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe 
                140                 145                 150 

Phe Pro Asp Val Ile Lys Ile His Trp Glu Glu Lys Lys Ser Asn 
                155                 160                 165 

Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp 
                170                 175                 180 

Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys Ser Leu 
                185                 190                 195 

Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn 
                200                 205                 210 

Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
                215                 220                 225 

Ile Thr Met Asp Pro Lys Asp Asn 
                230             

<210>  155
<211>  249
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TCR clone 3  TRG_Cg2_soluble_no signal pept

<400>  155
Asn Leu Glu Gly Arg Thr Lys Ser Val Thr Arg Gln Thr Gly Ser 
1               5                   10                  15  

Ser Ala Glu Ile Thr Cys Asp Leu Thr Val Thr Asn Thr Phe Tyr 
                20                  25                  30  

Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln Arg Leu 
                35                  40                  45  

Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp Val Leu Glu Ser Gly 
                50                  55                  60  

Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr Pro Arg Arg Trp Ser 
                65                  70                  75  

Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu Asn Asp Ser Gly Val 
                80                  85                  90  

Tyr Tyr Cys Ala Thr Trp Asp Gly Tyr Tyr Lys Lys Leu Phe Gly 
                95                  100                 105 

Ser Gly Thr Thr Leu Val Val Thr Asp Lys Gln Leu Asp Ala Asp 
                110                 115                 120 

Val Ser Pro Lys Pro Thr Ile Phe Leu Pro Ser Ile Ala Glu Thr 
                125                 130                 135 

Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys Leu Leu Glu Lys Phe 
                140                 145                 150 

Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu Lys Lys Ser Asn 
                155                 160                 165 

Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys Thr Asn Asp 
                170                 175                 180 

Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu Ser Leu 
                185                 190                 195 

Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys Asn 
                200                 205                 210 

Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
                215                 220                 225 

Thr Thr Val Asp Pro Lys Tyr Asn Tyr Ser Lys Asp Ala Asn Asp 
                230                 235                 240 

Val Ile Thr Met Asp Pro Lys Asp Asn 
                245                 

<210>  156
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  signal pept gamma

<400>  156
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys 
1               5                   10                  15  

Leu Glu Phe Ser Met Ala Arg Thr Ser Ser 
                20                  25  

<210>  157
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  signal pept delta

<400>  157
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys 
1               5                   10                  15  

Leu Glu Phe Ser Met Ala Ser Ala Ala Gln 
                20                  25  

<210>  158
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRGC1 TM domain

<400>  158
Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe 
1               5                   10                  15  

Ala Ile Ile Thr Cys Cys Leu Leu 
                20              

<210>  159
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRGC2 TM domain

<400>  159
Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe 
1               5                   10                  15  

Ala Ile Ile Thr Cys Cys Leu Leu 
                20              

<210>  160
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TRDC TM domain

<400>  160
Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe 
1               5                   10                  15  

Leu Leu Thr Ala Lys Leu Phe Phe 
                20              

<210>  161
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cg2

<400>  161
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe 
1               5                   10                  15  

Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                20                  25                  30  

Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His 
                35                  40                  45  

Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly 
                50                  55                  60  

Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                65                  70                  75  

Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val 
                80                  85                  90  

Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe 
                95                  100                 105 

Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn 
                110                 115                 120 

Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp 
                125                 130                 135 

Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr 
                140                 145                 150 

Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser 
                155                 160                 165 

Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Gly Arg Thr 
                170                 175                 180 

Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                185                 

<210>  162
<211>  306
<212>  PRT
<213>  Homo sapiens

<220>
<223>  TRG full length clone 3

<400>  162
Met Arg Trp Ala Leu Leu Val Leu Leu Ala Phe Leu Ser Pro Ala 
1               5                   10                  15  

Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Thr 
                20                  25                  30  

Arg Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Thr Val 
                35                  40                  45  

Thr Asn Thr Phe Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys 
                50                  55                  60  

Ala Pro Gln Arg Leu Leu Tyr Tyr Asp Val Ser Thr Ala Arg Asp 
                65                  70                  75  

Val Leu Glu Ser Gly Leu Ser Pro Gly Lys Tyr Tyr Thr His Thr 
                80                  85                  90  

Pro Arg Arg Trp Ser Trp Ile Leu Arg Leu Gln Asn Leu Ile Glu 
                95                  100                 105 

Asn Asp Ser Gly Val Tyr Tyr Cys Ala Thr Trp Asp Gly Tyr Tyr 
                110                 115                 120 

Lys Lys Leu Phe Gly Ser Gly Thr Thr Leu Val Val Thr Asp Lys 
                125                 130                 135 

Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu Pro 
                140                 145                 150 

Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
                155                 160                 165 

Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Glu 
                170                 175                 180 

Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr 
                185                 190                 195 

Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val 
                200                 205                 210 

Pro Glu Lys Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His 
                215                 220                 225 

Glu Asn Asn Lys Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro 
                230                 235                 240 

Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser 
                245                 250                 255 

Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser 
                260                 265                 270 

Ala Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr 
                275                 280                 285 

Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys 
                290                 295                 300 

Cys Asn Gly Glu Lys Ser 
                305     

<210>  163
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cg2 domain

<400>  163
Asp Val Thr Thr Val Asp Pro Lys Tyr Asn Tyr Ser Lys Asp Ala 
1               5                   10                  15  

Asn 
    

<210>  164
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cg2

<400>  164
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe 
1               5                   10                  15  

Leu Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr 
                20                  25                  30  

Leu Cys Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His 
                35                  40                  45  

Trp Gln Glu Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly 
                50                  55                  60  

Asn Thr Met Lys Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu 
                65                  70                  75  

Thr Val Pro Glu Glu Ser Leu Asp Lys Glu His Arg Cys Ile Val 
                80                  85                  90  

Arg His Glu Asn Asn Lys Asn Gly Ile Asp Gln Glu Ile Ile Phe 
                95                  100                 105 

Pro Pro Ile Lys Thr Asp Val Thr Thr Val Asp Pro Lys Tyr Asn 
                110                 115                 120 

Tyr Ser Lys Asp Ala Asn Asp Val Ile Thr Met Asp Pro Lys Asp 
                125                 130                 135 

Asn Trp Ser Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr 
                140                 145                 150 

Asn Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu Leu Leu Leu Lys Ser 
                155                 160                 165 

Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr 
                170                 175                 180 

Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                185                 

<210>  165
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cg2 domain

<400>  165
Thr Thr Val Asp Pro Lys Tyr Asn Tyr Ser Lys Asp Ala Asn 
1               5                   10                  



