﻿序列表 

<110>  南京北恒生物科技有限公司
       浙江大学医学院附属第一医院
 
<120>  用于细胞免疫治疗的方法和组合物

<130>  OWO22171098

<150> CN202110630650.4
<151> 2021-06-07

<160>  44  

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv CDR-L1

<400>  1
Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His
                5                   10


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv CDR-L2

<400>  2
Ser Ala Ser Gln Ser Ile Ser
                5


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv CDR-L3

<400>  3
Gln Gln Ser Asn Ser Trp Pro Tyr Thr
                5                   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv CDR-H1

<400>  4
Gly Tyr Thr Phe Thr Ser Tyr
                5


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv CDR-H2

<400>  5
Asn Pro Ser Asn Gly Arg
                5


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv CDR-H3

<400>  6
Gly Gly Val Tyr Tyr Asp Leu Tyr Tyr Tyr Ala Leu Asp Tyr
                5                   10                 


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv VL

<400>  7
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
                5                   10                  15

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn
            20                  25                  30

Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45

Lys Ser Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60

Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80

Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Tyr
                85                  90                  95

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105                 
                

<210>  8
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv VH

<400>  8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
                5                   10                  15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30

Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45

Gly Lys Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Arg Gly Gly Val Tyr Tyr Asp Leu Tyr Tyr Tyr Ala Leu Asp Tyr
            100                 105                 110

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                

     
<210>  9
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD7 scFv

<400>  9
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
                5                   10                  15

Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn
            20                  25                  30

Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45

Lys Ser Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60

Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80

Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Tyr
                85                  90                  95

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Ser Thr Ser
            100                 105                 110

Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val 
        115                 120                 125

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
    130                 135                 140

Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met
145                 150                 155                 160

His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Lys 
                165                 170                 175

Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Ala Gln Lys Phe Gln Gly 
            180                 185                 190

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
        195                 200                 205

Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220

Gly Gly Val Tyr Tyr Asp Leu Tyr Tyr Tyr Ala Leu Asp Tyr Trp Gly 
225                 230                 235                 240

Gln Gly Thr Leu Val Thr Val Ser Ser
                245                                


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv CDR-L1

<400>  10
Ser Ala Ser Ser Ser Val Ser Ser Tyr Ile Tyr
                5                   10


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv CDR-L2

<400>  11
Leu Thr Ser Asn Leu Ala Ser
                5


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv CDR-L3

<400>  12
Gln Gln Trp Ser Gly Asn Pro Tyr Thr
                5                   


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv CDR-H1

<400>  13
Gly Phe Thr Phe Ser Ser Tyr
                5


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv CDR-H2

<400>  14
Ser Ser Gly Gly Ser Tyr
                5


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv CDR-H3

<400>  15
His Gly Asp Tyr Pro Arg Phe Phe Asp Val
                5                   10                                


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv VL

<400>  16
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
                5                   10                  15

Glu Arg Ala Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Tyr
            20                  25                  30

Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45

Tyr Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Asn Pro Tyr
                85                  90                  95

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105  


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv VH

<400>  17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45

Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Thr Arg His Gly Asp Tyr Pro Arg Phe Phe Asp Val Trp Gly Gln Gly
            100                 105                 110

Thr Thr Val Thr Val Ser Ser
        115


<210>  18
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  NKG2A scFv

<400>  18
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
                5                   10                  15

Glu Arg Ala Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Tyr
            20                  25                  30

Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45

Tyr Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro
65                  70                  75                  80

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Asn Pro Tyr
                85                  90                  95

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly
            100                 105                 110

Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln 
        115                 120                 125

Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg 
    130                 135                 140

Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
145                 150                 155                 160

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Glu Ile 
                165                 170                 175

Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg 
            180                 185                 190

Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
        195                 200                 205

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg His 
    210                 215                 220

Gly Asp Tyr Pro Arg Phe Phe Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240

Thr Val Ser Ser
 

<210>  19
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α跨膜结构域

<400>  19
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                5                   10                  15

Ser Leu Val Ile Thr Leu Tyr Cys Lys
            20                  25


<210>  20
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α跨膜结构域

<400>  20
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     60

accctttact gcaaa                                                      75


<210>  21
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28跨膜结构域

<400>  21
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                5                   10                  15

Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25


<210>  22
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28跨膜结构域

<400>  22
ttttgggtcc tcgtcgtagt tggaggggta cttgcctgtt atagcctcct ggttaccgta     60

gcatttatta tattctgggt g                                               81


<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28共刺激结构域

<400>  23
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                5                   10                  15

Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30

Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40


<210>  24
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28共刺激结构域

<400>  24
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc    120

tcc                                                                  123


<210>  25
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB共刺激结构域

<400>  25
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                5                   10                  15

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
            20                  25                  30

Glu Glu Glu Glu Gly Gly Cys Glu
        35                  40


<210>  26
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB共刺激结构域

<400>  26
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     60

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     120


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  27
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                5                   10                  15

Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60

Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80

Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95

Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110

Arg


<210>  28
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  28
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac    180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag    240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac    300

acctacgacg cccttcacat gcaggccctg ccccctcgc                           339


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  B2M信号肽

<400>  29
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser
                5                   10                  15

Gly Leu Glu Ala
            20


<210>  30
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  B2M信号肽

<400>  30
atgtcccgct ctgttgcttt ggctgtgctg gcccttttgt cccttagcgg actggaggcc     60


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α信号肽

<400>  31
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
                5                   10                  15

His Ala Ala Arg Pro
            20


<210>  32
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α信号肽

<400>  32
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccg                                                                   63


<210>  33
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α铰链区

<400>  33
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
                5                   10                  15

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
        35                  40                  45


<210>  34
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α铰链区

<400>  34
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    120

gacttcgcct gtgat                                                     135


<210>  35
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28铰链区

<400>  35
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
                5                   10                  15

Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30

Phe Pro Gly Pro Ser Lys Pro
        35


<210>  36
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28铰链区

<400>  36
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc     60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc       117


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4铰链区

<400>  37
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
                5                   10


<210>  38
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4铰链区

<400>  38
gaaagcaaat acgggccgcc gtgtccaccc tgtccg                               36


<210>  39
<211>  1107
<212>  DNA
<213>  人工序列

<220>
<223>  γc链

<400>  39
atgttgaagc catcattacc attcacatcc ctcttattcc tgcagctgcc cctgctggga     60  

gtggggctga acacgacaat tctgacgccc aatgggaatg aagacaccac agctgatttc    120

ttcctgacca ctatgcccac tgactccctc agtgtttcca ctctgcccct cccagaggtt    180

cagtgttttg tgttcaatgt cgagtacatg aattgcactt ggaacagcag ctctgagccc    240

cagcctacca acctcactct gcattattgg tacaagaact cggataatga taaagtccag    300

aagtgcagcc actatctatt ctctgaagaa atcacttctg gctgtcagtt gcaaaaaaag    360

gagatccacc tctaccaaac atttgttgtt cagctccagg acccacggga acccaggaga    420

caggccacac agatgctaaa actgcagaat ctggtgatcc cctgggctcc agagaaccta    480

acacttcaca aactgagtga atcccagcta gaactgaact ggaacaacag attcttgaac    540

cactgtttgg agcacttggt gcagtaccgg actgactggg accacagctg gactgaacaa    600 

tcagtggatt atagacataa gttctccttg cctagtgtgg atgggcagaa acgctacacg    660

tttcgtgttc ggagccgctt taacccactc tgtggaagtg ctcagcattg gagtgaatgg    720

agccacccaa tccactgggg gagcaatact tcaaaagaga atcctttcct gtttgcattg    780

gaagccgtgg ttatctctgt tggctccatg ggattgatta tcagccttct ctgtgtgtat    840

ttctggctgg aacggacgat gccccgaatt cccaccctga agaacctaga ggatcttgtt    900

actgaatacc acgggaactt ttcggcctgg agtggtgtgt ctaagggact ggctgagagt    960

ctgcagccag actacagtga acgactctgc ctcgtcagtg agattccccc aaaaggaggg   1020

gcccttgggg aggggcctgg ggcctcccca tgcaaccagc atagccccta ctgggccccc   1080

ccatgttaca ccctaaagcc tgaaacc                                       1107


<210>  40
<211>  369
<212>  PRT
<213>  人工序列

<220>
<223>  γc链

<400>  40
Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu
                5                   10                  15
 
Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly
            20                  25                  30

Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp
        35                  40                  45

Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val
    50                  55                  50

Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro
65                  70                  75                  80

Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn
                85                  90                  95

Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr
            100                 105                 110

Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe
        115                 120                 125

Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln
    130                 135                 140

Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu
145                 150                 155                 160

Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn
                165                 170                 175

Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp
            180                 185                 190

Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe
        195                 200                 205

Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg
    210                 215                 220

Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240

Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255
            
Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu
            260                 265                 270

Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro
        275                 280                 285

Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His
    290                 295                 300

Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser
305                 310                 315                 320

Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro
                325                 330                 335

Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn
            340                 345                 350

Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu
        355                 360                 365

Thr


<210>  41
<211>  258
<212>  DNA
<213>  人工序列

<220>
<223>  γc链胞内区

<400>  41
gaacggacga tgccccgaat tcccaccctg aagaacctag aggatcttgt tactgaatac     60

cacgggaact tttcggcctg gagtggtgtg tctaagggac tggctgagag tctgcagcca    120
               

<210>  42
<211>  86
<212>  PRT
<213>  人工序列

<220>
<223>  γc链胞内区

<400>  42
Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu
                5                   10                  15
 
Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30

Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45

Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60

Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr
65                  70                  75                  80

Thr Leu Lys Pro Glu Thr
                85


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  接头

<400>  43
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
                5                   10                  15

Lys Gly
              

<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  接头

<400>  44
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
                5                   10                  15