                         б

<110>  ϺҽҩƼ޹˾ż޹˾

<120>  MASP-2弰;

<130>  0134-PA-036

<160>  77

<170>  PatentIn version 3.5

<210>  1
<211>  433
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hMASP2-D456

<400>  1

Met Ala Ser Met Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala His 
1               5                   10                  15      


Ala Cys Pro Tyr Pro Met Ala Pro Pro Asn Gly His Val Ser Pro Val 
            20                  25                  30          


Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr 
        35                  40                  45              


Gly Tyr Glu Leu Leu Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala 
    50                  55                  60                  


Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser 
65                  70                  75                  80  


Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu 
                85                  90                  95      


Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr 
            100                 105                 110         


Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr 
        115                 120                 125             


Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser 
    130                 135                 140                 


Leu Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly 
145                 150                 155                 160 


Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp 
                165                 170                 175     


Gln Val Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr 
            180                 185                 190         


Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His 
        195                 200                 205             


Asp Ala Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser 
    210                 215                 220                 


Pro His Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly 
225                 230                 235                 240 


Tyr Thr His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu 
                245                 250                 255     


Asn Asn Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro 
            260                 265                 270         


Arg Lys Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala 
        275                 280                 285             


Ser Gly Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met 
    290                 295                 300                 


Tyr Val Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr 
305                 310                 315                 320 


Glu Lys Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys 
                325                 330                 335     


Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly 
            340                 345                 350         


Gly Ala Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly 
        355                 360                 365             


Gly Ile Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr 
    370                 375                 380                 


Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile 
385                 390                 395                 400 


Ile Ser Asp Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Lys 
                405                 410                 415     


Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala His His His His His 
            420                 425                 430         


His 
    


<210>  2
<211>  432
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  hMASP2A-D456

<400>  2

Met Ala Ser Met Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala His 
1               5                   10                  15      


Ala Cys Pro Tyr Pro Met Ala Pro Pro Asn Gly His Val Ser Pro Val 
            20                  25                  30          


Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr 
        35                  40                  45              


Gly Tyr Glu Leu Leu Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala 
    50                  55                  60                  


Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser 
65                  70                  75                  80  


Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu 
                85                  90                  95      


Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr 
            100                 105                 110         


Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr 
        115                 120                 125             


Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser 
    130                 135                 140                 


Leu Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly 
145                 150                 155                 160 


Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp 
                165                 170                 175     


Gln Val Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr 
            180                 185                 190         


Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His 
        195                 200                 205             


Asp Ala Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser 
    210                 215                 220                 


Pro His Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly 
225                 230                 235                 240 


Tyr Thr His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu 
                245                 250                 255     


Asn Asn Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro 
            260                 265                 270         


Arg Lys Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala 
        275                 280                 285             


Ser Gly Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met 
    290                 295                 300                 


Tyr Val Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr 
305                 310                 315                 320 


Glu Lys Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys 
                325                 330                 335     


Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ala Gly 
            340                 345                 350         


Gly Ala Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly 
        355                 360                 365             


Gly Ile Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr 
    370                 375                 380                 


Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile 
385                 390                 395                 400 


Ile Ser Asp Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Lys 
                405                 410                 415     


Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala His His His His His 
            420                 425                 430         


<210>  3
<211>  432
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  mMASP2-D456

<400>  3

Met Ala Ser Met Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Arg 
1               5                   10                  15      


Pro Cys Pro Asp Pro Thr Ala Pro Pro Asn Gly Ser Ile Ser Pro Val 
            20                  25                  30          


Gln Ala Ile Tyr Val Leu Lys Asp Arg Phe Ser Val Phe Cys Lys Thr 
        35                  40                  45              


Gly Phe Glu Leu Leu Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala 
    50                  55                  60                  


Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro Glu Cys Ser 
65                  70                  75                  80  


Ile Ile Asp Cys Gly Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp 
                85                  90                  95      


Tyr Ile Thr Gly Pro Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr 
            100                 105                 110         


Ser Cys Glu Glu Thr Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val 
        115                 120                 125             


Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Leu Pro 
    130                 135                 140                 


Pro Val Cys Glu Pro Val Cys Gly Leu Ser Thr His Thr Ile Gly Gly 
145                 150                 155                 160 


Arg Ile Val Gly Gly Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln 
                165                 170                 175     


Val Leu Leu Leu Gly Gln Thr Thr Ala Ala Ala Gly Ala Leu Ile His 
            180                 185                 190         


Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Lys Arg Met 
        195                 200                 205             


Ala Ala Ser Ser Leu Asn Ile Arg Met Gly Ile Leu Lys Arg Leu Ser 
    210                 215                 220                 


Pro His Tyr Thr Gln Ala Trp Pro Glu Glu Ile Phe Ile His Glu Gly 
225                 230                 235                 240 


Tyr Thr His Gly Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu 
                245                 250                 255     


Lys Asn Lys Val Thr Ile Asn Gly Ser Ile Met Pro Val Cys Leu Pro 
            260                 265                 270         


Arg Lys Glu Ala Ala Ser Leu Met Arg Thr Asp Phe Thr Gly Thr Val 
        275                 280                 285             


Ala Gly Trp Gly Leu Thr Gln Lys Gly Leu Leu Ala Arg Asn Leu Met 
    290                 295                 300                 


Phe Val Asp Ile Pro Ile Ala Asp His Gln Lys Cys Thr Ala Val Tyr 
305                 310                 315                 320 


Glu Lys Leu Tyr Pro Gly Val Arg Val Ser Ala Asn Met Leu Cys Ala 
                325                 330                 335     


Gly Leu Glu Thr Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly 
            340                 345                 350         


Ala Leu Val Phe Leu Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly 
        355                 360                 365             


Ile Val Ser Trp Gly Ser Ile Asn Cys Gly Ala Ala Asp Gln Tyr Gly 
    370                 375                 380                 


Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile 
385                 390                 395                 400 


Ser Asn Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Lys Phe 
                405                 410                 415     


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala His His His His His His 
            420                 425                 430         


<210>  4
<211>  433
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  cMASP2-D456

<400>  4

Met Ala Ser Met Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln 
1               5                   10                  15      


Pro Cys Pro Tyr Pro Met Ala Pro Pro Asn Gly His Leu Ser Pro Val 
            20                  25                  30          


Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Pro 
        35                  40                  45              


Gly Tyr Glu Leu Leu Gln Gly His Leu Pro Leu Lys Ser Phe Ala Ala 
    50                  55                  60                  


Val Cys Gln Lys Asp Gly Ser Trp Asp Gln Pro Met Pro Ser Cys Ser 
65                  70                  75                  80  


Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu 
                85                  90                  95      


Tyr Ile Thr Gly Pro Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr 
            100                 105                 110         


Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr 
        115                 120                 125             


Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Arg Ser 
    130                 135                 140                 


Pro Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly 
145                 150                 155                 160 


Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp 
                165                 170                 175     


Gln Val Leu Ile Leu Gly Gly Ser Thr Ala Ala Gly Ala Leu Leu Tyr 
            180                 185                 190         


Asp Asn Trp Val Leu Thr Ala Ala His Ala Ile Tyr Glu Gln Lys His 
        195                 200                 205             


Asp Ala Ser Ser Leu Asp Ile Arg Leu Gly Ala Leu Lys Arg Leu Ser 
    210                 215                 220                 


Pro His Tyr Thr Gln Ala Trp Ala Glu Ala Val Phe Ile His Glu Gly 
225                 230                 235                 240 


Tyr Thr His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu 
                245                 250                 255     


Asn Asn Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro 
            260                 265                 270         


Arg Lys Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala 
        275                 280                 285             


Ser Gly Trp Gly Leu Thr Gln Arg Gly Leu Leu Ala Arg Asn Leu Met 
    290                 295                 300                 


Tyr Val Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr 
305                 310                 315                 320 


Glu Lys Pro Pro Tyr Ser Gly Gly Ser Val Thr Ala Asn Met Leu Cys 
                325                 330                 335     


Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly 
            340                 345                 350         


Gly Ala Leu Val Phe Leu Asp Asn Glu Thr Gln Arg Trp Phe Val Gly 
        355                 360                 365             


Gly Ile Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr 
    370                 375                 380                 


Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Lys Asn Ile 
385                 390                 395                 400 


Ile Ser Asn Phe Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Lys 
                405                 410                 415     


Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala His His His His His 
            420                 425                 430         


His 


<210>  5
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6ɱ

<400>  5

Asn Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Ser Asn Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Arg Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Arg Val Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ser Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Leu Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
            100                 105         


<210>  6
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 L-FR1

<400>  6

Asn Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Leu Ser Cys 
            20              


<210>  7
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 LCDR1JYB1931A63 LCDR1

<400>  7

Arg Ala Ser Gln Ser Val Ser Thr Ser Ile His 
1               5                   10      


<210>  8
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 L-FR2

<400>  8

Trp Tyr Gln Gln Arg Ser Asn Glu Ser Pro Arg Leu Leu Ile Lys 
1               5                   10                  15  


<210>  9
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 LCDR2JYB1931A63 LCDR2

<400>  9

Tyr Ala Ser Arg Ser Ile Ser 
1               5           


<210>  10
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 L-FR3

<400>  10

Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Ser Ile Asn Arg Val Glu Ser Glu Asp Phe Ser Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  11
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 LCDR3JYB1931A63 LCDR3

<400>  11

Gln Gln Ser Tyr Ser Ser Leu Tyr Thr 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 L-FR4

<400>  12

Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
1               5                   10  


<210>  13
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6ɱ

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Thr Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Leu Phe Asp Gly Ser Arg Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Glu Ser Pro Tyr Tyr Ser Glu Gly Tyr Tyr Gln Gly Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 H-FR1

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  15
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 HCDR1JYB1931A63 HCDR1

<400>  15

Gly Phe Thr Phe Asn Asp Tyr 
1               5           


<210>  16
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 H-FR2

<400>  16

Asn Met Ala Trp Val Arg Gln Thr Pro Lys Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Thr Ile 
            


<210>  17
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 HCDR2JYB1931A63 HCDR2

<400>  17

Leu Phe Asp Gly Ser Arg 
1               5       


<210>  18
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 H-FR3

<400>  18

Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu 
1               5                   10                  15      


Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg Ser Glu 
            20                  25                  30          


Asp Thr Ala Thr Tyr Tyr Cys Ser Thr 
        35                  40      


<210>  19
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 HCDR3;JYB1931A63 HCDR3

<400>  19

Glu Ser Pro Tyr Tyr Ser Glu Gly Tyr Tyr Gln Gly Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  20
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  50A6 H-FR4

<400>  20

Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63ɱ

<400>  21

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Arg Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  22
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 L-FR1

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  23
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 L-FR2

<400>  23

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Lys 
1               5                   10                  15  


<210>  24
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 L-FR3

<400>  24

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  25
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 L-FR4

<400>  25

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  26
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63ɱ

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Leu Phe Asp Gly Ser Arg Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Glu Ser Pro Tyr Tyr Ser Glu Gly Tyr Tyr Gln Gly Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  27
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 H-FR1

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  28
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 H-FR2

<400>  28

Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Thr Ile 
            


<210>  29
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 H-FR3

<400>  29

Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ser Thr 
        35                  40      


<210>  30
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63 H-FR4;JYB1931A13 H-FR4

<400>  30

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  31
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1ɱ

<400>  31

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys His Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Asn 
            100                 105         


<210>  32
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 L-FR1

<400>  32

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys 
            20              


<210>  33
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 LCDR1;JYB1931A13 LCDR1

<400>  33

Lys Ala Ser Gln Asn Val Gly Ser Asn Val Ala 
1               5                   10      


<210>  34
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 L-FR2

<400>  34

Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr 
1               5                   10                  15  


<210>  35
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 LCDR2;JYB1931A13 LCDR2

<400>  35

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  36
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 L-FR3

<400>  36

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys 
            20                  25                  30          


<210>  37
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 LCDR3;JYB1931A13 LCDR3

<400>  37

His Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  38
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 L-FR4

<400>  38

Phe Gly Ala Gly Thr Lys Leu Glu Leu Asn 
1               5                   10  


<210>  39
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1ɱ

<400>  39

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Arg Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asn Thr Ser Thr Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Trp Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  40
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 H-FR1

<400>  40

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25  


<210>  41
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 HCDR1;JYB1931A13 HCDR1

<400>  41

Gly Tyr Ser Ile Thr Ser Asp Tyr 
1               5               


<210>  42
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 H-FR2

<400>  42

Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  43
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 HCDR2;JYB1931A13 HCDR2

<400>  43

Ser Tyr Ser Gly Arg 
1               5   


<210>  44
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 H-FR3

<400>  44

Thr Ser Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asn 
1               5                   10                  15      


Thr Ser Thr Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu 
            20                  25                  30          


Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
        35                  40      


<210>  45
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 HCDR3;JYB1931A13 HCDR3

<400>  45

Tyr Trp Gly Asp Tyr 
1               5   


<210>  46
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  47A1 H-FR4

<400>  46

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  47
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13ɱ

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys His Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  48
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13 L-FR1

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  49
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13 L-FR2

<400>  49

Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr 
1               5                   10                  15  


<210>  50
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13 L-FR3

<400>  50

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  51
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13 L-FR4

<400>  51

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  52
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13ɱ

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Arg Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Trp Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  53
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13 H-FR1

<400>  53

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  54
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13 H-FR2

<400>  54

Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  55
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A13 H-FR3

<400>  55

Thr Ser Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  56
<211>  327
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63㶨;JYB1931A13㶨

<400>  56

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  57
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  JYB1931A63㶨JYB1931A13㶨

<400>  57

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         




<210>  58
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1ͨʽ1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GluAsn

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = SerThr

<400>  58

Xaa Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Xaa Xaa Pro Gly 
1               5                   10                  15      


Glu Xaa Xaa Xaa Leu Ser Cys 
            20              


<210>  59
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2ͨʽ1

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = GlyAsn

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaSer

<400>  59

Trp Tyr Gln Gln Xaa Xaa Xaa Xaa Xaa Pro Arg Leu Leu Ile Lys 
1               5                   10                  15  


<210>  60
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR3ͨʽ1

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = IleVal

<400>  60

Gly Ile Pro Xaa Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Xaa Ile Xaa Xaa Xaa Glu Xaa Glu Asp Phe Xaa Xaa Tyr Tyr Cys 
            20                  25                  30          


<210>  61
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4ͨʽ1

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = LysArg

<400>  61

Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Xaa 
1               5                   10  


<210>  62
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ1

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = ArgSer

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  63
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽ1

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = GlyLys

<400>  63

Asn Met Ala Trp Val Arg Gln Xaa Pro Xaa Lys Gly Leu Glu Trp Val 
1               5                   10                  15      


Ala Thr Ile 
            


<210>  64
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽ1

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = ThrVal

<400>  64

Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Xaa 
1               5                   10                  15      


Asn Ala Lys Xaa Xaa Leu Tyr Leu Gln Met Xaa Ser Leu Arg Xaa Glu 
            20                  25                  30          


Asp Thr Ala Xaa Tyr Tyr Cys Ser Thr 
        35                  40      


<210>  65
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ1

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuMet

<400>  65

Trp Gly Gln Gly Xaa Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  66
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL ͨʽ1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GluAsn

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa = GlyAsn

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = AlaGln

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa = LysArg

<400>  66

Xaa Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Xaa Xaa Pro Gly 
1               5                   10                  15      


Glu Xaa Xaa Xaa Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Xaa Xaa Xaa Xaa Xaa Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Arg Ser Ile Ser Gly Ile Pro Xaa Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Xaa Ile Xaa Xaa Xaa Glu Xaa 
65                  70                  75                  80  


Glu Asp Phe Xaa Xaa Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Leu Tyr 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Xaa 
            100                 105         


<210>  67
<211>  125
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH ͨʽ1

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = GlyLys

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa = LeuMet

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Asn Met Ala Trp Val Arg Gln Xaa Pro Xaa Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Leu Phe Asp Gly Ser Arg Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Xaa Asn Ala Lys Xaa Xaa Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Xaa Ser Leu Arg Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Glu Ser Pro Tyr Tyr Ser Glu Gly Tyr Tyr Gln Gly Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Xaa Xaa Val Thr Val Ser Ser 
        115                 120                 125 


<210>  68
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1ͨʽ2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = ProGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = LysSer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = PheSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = IleVal

<400>  68

Asp Ile Xaa Met Thr Gln Ser Xaa Xaa Xaa Xaa Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Xaa Xaa Thr Cys 
            20              


<210>  69
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2ͨʽ2

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaSer

<400>  69

Trp Phe Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Pro Leu Ile Tyr 
1               5                   10                  15  


<210>  70
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR3ͨʽ2

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = GluThr

<400>  70

Gly Val Pro Xaa Arg Phe Xaa Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Xaa Xaa Gln Xaa Glu Asp Xaa Ala Xaa Tyr Phe Cys 
            20                  25                  30          


<210>  71
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4ͨʽ2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = LysAsn

<400>  71

Phe Gly Xaa Gly Thr Lys Xaa Glu Xaa Xaa 
1               5                   10  


<210>  72
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AspGln

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = SerThr

<400>  72

Xaa Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Thr Val Xaa 
            20                  25  


<210>  73
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽ2

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = PhePro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = GlyLys

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = IleMet

<400>  73

Ala Trp Asn Trp Ile Arg Gln Xaa Pro Gly Xaa Xaa Leu Glu Trp Xaa 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  74
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽ2

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = LysThr

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = PheSer

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = AlaGlu

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa = PheTyr

<400>  74

Thr Ser Tyr Asn Pro Ser Leu Lys Ser Arg Xaa Xaa Ile Xaa Arg Xaa 
1               5                   10                  15      


Thr Ser Xaa Asn Gln Phe Xaa Leu Xaa Leu Xaa Ser Val Thr Xaa Xaa 
            20                  25                  30          


Asp Thr Ala Xaa Tyr Xaa Cys Ala Arg 
        35                  40      


<210>  75
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ2

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuThr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = LeuVal

<400>  75

Trp Gly Gln Gly Thr Xaa Xaa Thr Val Ser Ser 
1               5                   10      


<210>  76
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL ͨʽ2

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = ProGln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = LysSer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = PheSer

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = GluThr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa = LysAsn

<400>  76

Asp Ile Xaa Met Thr Gln Ser Xaa Xaa Xaa Xaa Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Xaa Xaa Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Xaa Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Xaa Xaa Gln Xaa 
65                  70                  75                  80  


Glu Asp Xaa Ala Xaa Tyr Phe Cys His Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Xaa Glu Xaa Xaa 
            100                 105         


<210>  77
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH ͨʽ2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AspGln

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa = PhePro

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = GlyLys

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = IleMet

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = AspAsn

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = LysThr

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = PheSer

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaThr

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa = AlaGlu

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = LeuThr

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa = LeuVal

<400>  77

Xaa Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Thr Val Xaa Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Xaa Pro Gly Xaa Xaa Leu Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile Ser Tyr Ser Gly Arg Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Xaa Xaa Ile Xaa Arg Xaa Thr Ser Xaa Asn Gln Phe Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Ser Val Thr Xaa Xaa Asp Thr Ala Xaa Tyr Xaa Cys 
                85                  90                  95      


Ala Arg Tyr Trp Gly Asp Tyr Trp Gly Gln Gly Thr Xaa Xaa Thr Val 
            100                 105                 110         


Ser Ser 
