                         SEQUENCE LISTING

<110>  CURIA IP HOLDINGS, LLC
 
<120>  POLYMERIC FUSION PROTEINS AND COMPOSITIONS FOR INDUCING AN IMMUNE
        RESPONSE AGAINST INFECTION

<130>  147471.002112

<140>  PCT/US2022/032376
<141>  2022-06-06

<150>  63/196,905
<151>  2021-06-04

<150>  63/196,920
<151>  2021-06-04

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD fused to IgM Fc

<400>  1

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Ile Ala Glu Leu Pro Pro Lys Val Ser Val 
        275                 280                 285             


Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys 
    290                 295                 300                 


Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser 
305                 310                 315                 320 


Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln 
                325                 330                 335     


Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr 
            340                 345                 350         


Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Ser Gln Ser Met Phe 
        355                 360                 365             


Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser 
    370                 375                 380                 


Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile 
385                 390                 395                 400 


Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr 
                405                 410                 415     


Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp 
            420                 425                 430         


Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu 
        435                 440                 445             


Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys 
    450                 455                 460                 


Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His 
465                 470                 475                 480 


Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly 
                485                 490                 495     


Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu 
            500                 505                 510         


Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr Gly 
        515                 520                 525             


Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln Pro 
    530                 535                 540                 


Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro Gln 
545                 550                 555                 560 


Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu Glu 
                565                 570                 575     


Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu Ala 
            580                 585                 590         


Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly Lys 
        595                 600                 605             


Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly Thr 
    610                 615                 620                 


Cys Tyr 
625     


<210>  2
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  3
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  4
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD fused to kappa light chain constant region

<400>  4

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        275                 280                 285             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    290                 295                 300                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
305                 310                 315                 320 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                325                 330                 335     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            340                 345                 350         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        355                 360                 365             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    370                 375                 380 


<210>  5
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Ser Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser 
        115                 120                 125             


Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu 
    130                 135                 140                 


Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu 
145                 150                 155                 160 


Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr 
                165                 170                 175     


Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser 
            180                 185                 190         


Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro 
        195                 200                 205             


Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly Val Ala Leu His Arg Pro 
    210                 215                 220                 


Asp Val Tyr Leu Leu Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu 
225                 230                 235                 240 


Ser Ala Thr Ile Thr Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val 
                245                 250                 255     


Phe Val Gln Trp Met Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr 
            260                 265                 270         


Val Thr Ser Ala Pro Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe 
        275                 280                 285             


Ala His Ser Ile Leu Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu 
    290                 295                 300                 


Thr Tyr Thr Cys Val Val Ala His Glu Ala Leu Pro Asn Arg Val Thr 
305                 310                 315                 320 


Glu Arg Thr Val Asp Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val 
                325                 330                 335     


Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            340                 345             


<210>  6
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  7
<211>  223
<212>  PRT
<213>  SARS-CoV-2

<400>  7

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycine/Serine Linker

<400>  8

Gly Gly Gly Gly Ser 
1               5   


<210>  9
<211>  951
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2(18-615)(H374N, H378N)-hIgM Fc

<400>  9

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gly Gly Gly Gly Ser Ile Ala Glu Leu Pro 
        595                 600                 605             


Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn 
    610                 615                 620                 


Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg 
625                 630                 635                 640 


Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly 
                645                 650                 655     


Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr 
            660                 665                 670         


Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu 
        675                 680                 685             


Ser Gln Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe 
    690                 695                 700                 


Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile 
705                 710                 715                 720 


Arg Val Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys 
                725                 730                 735     


Ser Thr Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser 
            740                 745                 750         


Val Thr Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His 
        755                 760                 765             


Thr Asn Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly 
    770                 775                 780                 


Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr 
785                 790                 795                 800 


Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile 
                805                 810                 815     


Ser Arg Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu 
            820                 825                 830         


Pro Pro Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr 
        835                 840                 845             


Cys Leu Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met 
    850                 855                 860                 


Gln Arg Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro 
865                 870                 875                 880 


Met Pro Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu 
                885                 890                 895     


Thr Val Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val 
            900                 905                 910         


Val Ala His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp 
        915                 920                 925             


Lys Ser Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser 
    930                 935                 940                 


Asp Thr Ala Gly Thr Cys Tyr 
945                 950     


<210>  10
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE2(18-615)(H374N, H378N)

<400>  10

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His Asn Glu Met Gly Asn Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp 
        595             


<210>  11
<211>  2853
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2(18-615)(H374N, H378N)-hIgM Fc

<400>  11
cagtcaacaa tcgaggagca ggcaaagacc ttcctggaca agtttaacca cgaagcggag       60

gacctgttct accagagcag cctggcgagc tggaattaca acaccaacat caccgaggag      120

aacgtgcaga acatgaataa cgctggcgac aagtggagcg ccttcttgaa ggagcaatcc      180

accctggccc agatgtaccc gctgcaagag atacagaacc tgactgtgaa gctgcaactg      240

caggccctgc agcagaacgg ctccagcgtg ctgagcgaag acaagagcaa aaggctgaat      300

accatattga acacgatgag caccatctac agcaccggca aagtatgcaa ccccgacaac      360

ccccaagagt gtctgttgtt ggaacccggc ctgaacgaga ttatggcgaa ctccctggac      420

tacaacgaac gcctgtgggc atgggagtct tggaggtcag aggttggcaa gcaactgagg      480

ccgttgtacg aagagtacgt ggtgctgaag aacgaaatgg cacgggccaa tcattatgag      540

gactacggtg attattggag gggcgactac gaggtgaacg gcgtggacgg ctacgactat      600

agcaggggcc aacttataga ggacgtagag cacacttttg aggaaatcaa acccctgtac      660

gagcacttgc atgcctacgt acgcgccaaa ctgatgaatg cgtaccccag ctacatcagc      720

cccatcggct gcctgcccgc acacctgctc ggcgacatgt ggggccgatt ctggaccaat      780

ctgtatagcc tcaccgtgcc ctttggccag aagccgaaca tagatgtgac ggatgctatg      840

gtagaccagg cgtgggatgc acagcgcatc ttcaaggagg ccgagaagtt cttcgtgagc      900

gtcggcttgc ccaacatgac ccagggtttc tgggagaact caatgctgac tgaccccggc      960

aacgtacaga aagccgtatg ccacccaact gcttgggacc tgggtaaggg agacttccgg     1020

atcctcatgt gtaccaaggt gaccatggat gactttctca ccgcccacaa tgaaatgggc     1080

aacatccagt acgatatggc ctacgcagcg cagccattcc ttctgaggaa cggtgccaac     1140

gagggcttcc atgaggcagt cggagagatc atgagcctgt cagcggcgac ccctaaacat     1200

ctgaagagca tcgggctgct gtctccggac tttcaagagg acaatgagac tgagatcaac     1260

ttcctcctga aacaggcgct gaccattgta ggcaccttgc ccttcaccta catgctggag     1320

aagtggcgat ggatggtgtt taagggcgag atcccgaagg accagtggat gaaaaagtgg     1380

tgggagatga agagggagat cgtcggcgta gttgagccgg tcccccacga cgaaacctac     1440

tgcgatcctg ccagcctgtt ccacgtgagc aacgattaca gttttatcag gtactacacc     1500

aggacccttt accaatttca gttccaggag gcactgtgcc aggccgccaa gcacgaaggc     1560

cccctgcaca agtgcgacat cagcaacagc accgaggcgg gtcaaaagct gtttaacatg     1620

ctgaggctgg gcaagagcga gccgtggacc ctggccctgg aaaacgttgt gggcgcaaaa     1680

aacatgaacg tgaggcccct gctgaactac ttcgagcccc tgttcacctg gctgaaggac     1740

cagaacaaga acagtttcgt gggctggagt accgattgga gtccctatgc cgacggtggc     1800

ggaggatcta ttgctgagct gcctcccaaa gtgagcgtct tcgtcccacc ccgcgacggc     1860

ttcttcggca acccccgcaa gtccaagctc atctgccagg ccacgggttt cagtccccgg     1920

cagattcagg tgtcctggct gcgcgagggg aagcaggtgg ggtctggcgt caccacggac     1980

caggtgcagg ctgaggccaa agagtctggg cccacgacct acaaggtgac cagcacactg     2040

accatcaaag agagcgactg gctcagccag agcatgttca cctgccgcgt ggatcacagg     2100

ggcctgacct tccagcagaa tgcgtcctcc atgtgtgtcc ccgatcaaga cacagccatc     2160

cgggtcttcg ccatcccccc atcctttgcc agcatcttcc tcaccaagtc caccaagttg     2220

acctgcctgg tcacagacct gaccacctat gacagcgtga ccatctcctg gacccgccag     2280

aatggcgaag ctgtgaaaac ccacaccaac atctccgaga gccaccccaa tgccactttc     2340

agcgccgtgg gtgaggccag catctgcgag gatgactgga attccgggga gaggttcacg     2400

tgcaccgtga cccacacaga cctgccctcg ccactgaagc agaccatctc ccggcccaag     2460

ggggtggccc tgcacaggcc cgatgtctac ttgctgccac cagcccggga gcagctgaac     2520

ctgcgggagt cggccaccat cacgtgcctg gtgacgggct tctctcccgc ggacgtcttc     2580

gtgcagtgga tgcagagggg gcagcccttg tccccggaga agtatgtgac cagcgcccca     2640

atgcctgagc cccaggcccc aggccggtac ttcgcccaca gcatcctgac cgtgtccgaa     2700

gaggaatgga acacggggga gacctacacc tgcgtggtgg cccatgaggc cctgcccaac     2760

agggtcaccg agaggaccgt ggacaagtcc accggtaaac ccaccctgta caacgtgtcc     2820

ctggtcatgt ccgacacagc tggcacctgc tac                                  2853


<210>  12
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  12

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Asp Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Phe Ala Pro Phe Phe Ala Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asn Glu Val Ser Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Val Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Arg Pro Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  13
<211>  1793
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACE2(18-615)(H374N, H378N)

<400>  13
cagtcaacaa tcgaggagca ggcaaagacc ttcctggaca agtttaacca cgaagcggag       60

gacctgttct accagagcag cctggcgagc tggaattaca acaccaacat caccgaggag      120

aacgtgcaga acatgaataa cgctggcgac aagtggagcg ccttcttgaa ggagcaatcc      180

accctggccc agatgtaccc gctgcaagag atacagaacc tgactgtgaa gctgcaactg      240

caggccctgc agcagaacgg ctccagcgtg ctgagcgaag acaagagcaa aaggctgaat      300

accatattga acacgatgag caccatctac agcaccggca aagtatgcaa ccccgacaac      360

ccccaagagt gtctgttgtt ggaacccggc ctgaacgaga ttatggcgaa ctccctggac      420

tacaacgaac gcctgtgggc atgggagtct tggaggtcag aggttggcaa gcaactgagg      480

ccgttgtacg aagagtacgt ggtgctgaag aacgaaatgg cacgggccaa tcattatgag      540

gactacggtg attattggag gggcgactac gaggtgaacg gcgtggacgg ctacgactat      600

agcaggggcc aacttataga ggacgtagag cacacttttg aggaaatcaa acccctgtac      660

gagcacttgc atgcctacgt acgcgccaaa ctgatgaatg cgtaccccag ctacatcagc      720

cccatcggct gcctgcccgc acacctgctc ggcgacatgt ggggccgatt ctggaccaat      780

ctgtatagcc tcaccgtgcc ctttggccag aagccgaaca tagatgtgac ggatgctatg      840

gtagaccagg cgtgggatgc acagcgcatc ttcaaggagg ccgagaagtt cttcgtgagc      900

gtcggcttgc ccaacatgac ccagggtttc tgggagaact caatgctgac tgaccccggc      960

aacgtacaga aagccgtatg ccacccaact gcttgggacc tgggtaaggg agacttccgg     1020

atcctcatgt gtaccaaggt gaccatggat gactttctca ccgcccacaa tgaaatgggc     1080

aacatccagt acgatatggc ctacgcagcg cagccattcc ttctgaggaa cggtgccaac     1140

gagggcttcc atgaggcagt cggagagatc atgagcctgt cagcggcgac ccctaaacat     1200

ctgaagagca tcgggctgct gtctccggac tttcaagagg acaatgagac tgagatcaac     1260

ttcctcctga aacaggcgct gaccattgta ggcaccttgc ccttcaccta catgctggag     1320

aagtggcgat ggatggtgtt taagggcgag atcccgaagg accagtggat gaaaaagtgg     1380

tgggagatga agagggagat cgtcggcgta gttgagccgg tcccccacga cgaaacctac     1440

tgcgatcctg ccagcctgtt ccacgtgagc aacgattaca gttttatcag gtactacacc     1500

aggacccttt accatttcag ttccaggagg cactgtgcca ggccgccaag cacgaaggcc     1560

ccctgcacaa gtgcgacatc agcaacagca ccgaggcggg tcaaaagctg tttaacatgc     1620

tgaggctggg caagagcgag ccgtggaccc tggccctgga aaacgttgtg ggcgcaaaaa     1680

acatgaacgt gaggcccctg ctgaactact tcgagcccct gttcacctgg ctgaaggacc     1740

agaacaagaa cagtttcgtg ggctggagta ccgattggag tccctatgcc gac            1793


<210>  14
<211>  1878
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBD-IgM-Fc fusion protein

<400>  14
agggtgcagc ccacggagag catcgtgagg tttcccaata taaccaacct ttgccccttc       60

ggggaagtct tcaatgccac ccggttcgca agcgtctacg cctggaacag gaagaggatc      120

tcaaactgcg tggccgacta tagcgtcctc tacaattcag catctttctc cactttcaaa      180

tgctacggcg ttagccccac caagctgaac gatctgtgtt ttaccaatgt gtacgccgat      240

agcttcgtca ttaggggtga cgaggtgagg cagattgcgc caggccagac cggcaagatc      300

gccgattaca actacaagtt gccggacgac tttaccggtt gcgttatcgc ctggaacagc      360

aacaatctgg acagcaaggt gggcggcaat tacaattacc tgtaccgact cttcaggaag      420

agcaacctga aacccttcga gagggacatc agcaccgaaa tctaccaggc cggcagcact      480

ccctgcaacg gggttgaggg gttcaactgc tacttcccgc tccagtcata cggcttccaa      540

ccaacaaacg gcgtagggta ccagccctac agggtggtgg tactgagctt cgaactcttg      600

cacgcacccg caacggtgtg cggaccgaag aagagtacca acttggtgaa gaacaagtgc      660

gtaaacttca atttcaatgg cctgacaggc accggcgtgc tgaccgagtc taacaagaag      720

ttcctgccgt tccagcagtt tggcagagac attgcggaca ccaccgatgc cgtgagggac      780

ccgcagaccc tggagatcct ggacataaca ccctgcagtg gtggcggagg atctattgct      840

gagctgcctc ccaaagtgag cgtcttcgtc ccaccccgcg acggcttctt cggcaacccc      900

cgcaagtcca agctcatctg ccaggccacg ggtttcagtc cccggcagat tcaggtgtcc      960

tggctgcgcg aggggaagca ggtggggtct ggcgtcacca cggaccaggt gcaggctgag     1020

gccaaagagt ctgggcccac gacctacaag gtgaccagca cactgaccat caaagagagc     1080

gactggctca gccagagcat gttcacctgc cgcgtggatc acaggggcct gaccttccag     1140

cagaatgcgt cctccatgtg tgtccccgat caagacacag ccatccgggt cttcgccatc     1200

cccccatcct ttgccagcat cttcctcacc aagtccacca agttgacctg cctggtcaca     1260

gacctgacca cctatgacag cgtgaccatc tcctggaccc gccagaatgg cgaagctgtg     1320

aaaacccaca ccaacatctc cgagagccac cccaatgcca ctttcagcgc cgtgggtgag     1380

gccagcatct gcgaggatga ctggaattcc ggggagaggt tcacgtgcac cgtgacccac     1440

acagacctgc cctcgccact gaagcagacc atctcccggc ccaagggggt ggccctgcac     1500

aggcccgatg tctacttgct gccaccagcc cgggagcagc tgaacctgcg ggagtcggcc     1560

accatcacgt gcctggtgac gggcttctct cccgcggacg tcttcgtgca gtggatgcag     1620

agggggcagc ccttgtcccc ggagaagtat gtgaccagcg ccccaatgcc tgagccccag     1680

gccccaggcc ggtacttcgc ccacagcatc ctgaccgtgt ccgaagagga atggaacacg     1740

ggggagacct acacctgcgt ggtggcccat gaggccctgc ccaacagggt caccgagagg     1800

accgtggaca agtccaccgg taaacccacc ctgtacaacg tgtccctggt catgtccgac     1860

acagctggca cctgctac                                                   1878


<210>  15
<211>  876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBD polypeptide

<400>  15
agggtgcagc ccacggagag catcgtgagg tttcccaata taaccaacct ttgccccttc       60

ggggaagtct tcaatgccac ccggttcgca agcgtctacg cctggaacag gaagaggatc      120

tcaaactgcg tggccgacta tagcgtcctc tacaattcag catctttctc cactttcaaa      180

tgctacggcg ttagccccac caagctgaac gatctgtgtt ttaccaatgt gtacgccgat      240

agcttcgtca ttaggggtga cgaggtgagg cagattgcgc caggccagac cggcaagatc      300

gccgattaca actacaagtt gccggacgac tttaccggtt gcgttatcgc ctggaacagc      360

aacaatctgg acagcaaggt gggcggcaat tacaattacc tgtaccgact cttcaggaag      420

agcaacctga aacccttcga gagggacatc agcaccgaaa tctaccaggc cggcagcact      480

ccctgcaacg gggttgaggg gttcaactgc tacttcccgc tccagtcata cggcttccaa      540

ccaacaaacg gcgtagggta ccagccctac agggtggtgg tactgagctt cgaactcttg      600

cacgcacccg caacggtgtg cggaccgaag aagagtacca acttggtgaa gaacaagtgc      660

gtaaacttca atttcaatgg cctgacaggc accggcgtgc tgaccgagtc taacaagaag      720

ttcctgccgt tccagcagtt tggcagagac attgcggaca ccaccgatgc cgtgagggac      780

ccgcagaccc tggagatcct ggacataaca ccctgcagtg gcggaggtgg tgcaggaggc      840

ggtggacacc accatcatca ccatcaccac catcac                                876


<210>  16
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  J Chain polypeptide

<400>  16
caggaagatg agcggatcgt gctggtggac aacaagtgca agtgcgcccg gatcacctcc       60

cggatcatcc ggtcctccga ggatcccaac gaggacatcg tggaacggaa catcagaatc      120

atcgtgcccc tgaacaaccg cgagaacatc tccgacccca ccagccctct gcggaccaga      180

ttcgtgtacc acctgtccga cctgtgcaag aagtgcgacc ctaccgaggt ggaactggac      240

aaccagatcg tgaccgccac ccagtccaac atctgcgacg aggactccgc caccgagaca      300

tgctacacct acgaccggaa caagtgctac accgccgtgg tgcctctggt gtacggcggc      360

gagacaaaga tggtggaaac cgccctgacc cccgacgcct gctatcctga t               411


<210>  17
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RBD-Kappa fusion protein

<400>  17
agggtgcagc ccacggagag catcgtgagg tttcccaata taaccaacct ttgccccttc       60

ggggaagtct tcaatgccac ccggttcgca agcgtctacg cctggaacag gaagaggatc      120

tcaaactgcg tggccgacta tagcgtcctc tacaattcag catctttctc cactttcaaa      180

tgctacggcg ttagccccac caagctgaac gatctgtgtt ttaccaatgt gtacgccgat      240

agcttcgtca ttaggggtga cgaggtgagg cagattgcgc caggccagac cggcaagatc      300

gccgattaca actacaagtt gccggacgac tttaccggtt gcgttatcgc ctggaacagc      360

aacaatctgg acagcaaggt gggcggcaat tacaattacc tgtaccgact cttcaggaag      420

agcaacctga aacccttcga gagggacatc agcaccgaaa tctaccaggc cggcagcact      480

ccctgcaacg gggttgaggg gttcaactgc tacttcccgc tccagtcata cggcttccaa      540

ccaacaaacg gcgtagggta ccagccctac agggtggtgg tactgagctt cgaactcttg      600

cacgcacccg caacggtgtg cggaccgaag aagagtacca acttggtgaa gaacaagtgc      660

gtaaacttca atttcaatgg cctgacaggc accggcgtgc tgaccgagtc taacaagaag      720

ttcctgccgt tccagcagtt tggcagagac attgcggaca ccaccgatgc cgtgagggac      780

ccgcagaccc tggagatcct ggacataaca ccctgcagtc ggaccgtggc cgcccccagc      840

gtgttcatct tccctcccag cgacgagcag ctgaagtctg gcaccgccag cgtggtgtgc      900

ctgctgaaca acttctaccc ccgcgaggcc aaggtgcagt ggaaggtgga caacgccctg      960

cagagcggca acagccagga gagcgtgacc gagcaggact ccaaggacag cacctacagc     1020

ctgagcagca ccctgaccct gagcaaggcc gactacgaga agcacaaggt gtacgcctgc     1080

gaggtgaccc accagggact gtctagcccc gtgaccaaga gcttcaaccg gggcgagtgc     1140


<210>  18
<211>  1044
<212>  DNA
<213>  Homo sapiens

<400>  18
attgctgagc tgcctcccaa agtgagcgtc ttcgtcccac cccgcgacgg cttcttcggc       60

aacccccgca agtccaagct catctgccag gccacgggtt tcagtccccg gcagattcag      120

gtgtcctggc tgcgcgaggg gaagcaggtg gggtctggcg tcaccacgga ccaggtgcag      180

gctgaggcca aagagtctgg gcccacgacc tacaaggtga ccagcacact gaccatcaaa      240

gagagcgact ggctcagcca gagcatgttc acctgccgcg tggatcacag gggcctgacc      300

ttccagcaga atgcgtcctc catgtgtgtc cccgatcaag acacagccat ccgggtcttc      360

gccatccccc catcctttgc cagcatcttc ctcaccaagt ccaccaagtt gacctgcctg      420

gtcacagacc tgaccaccta tgacagcgtg accatctcct ggacccgcca gaatggcgaa      480

gctgtgaaaa cccacaccaa catctccgag agccacccca atgccacttt cagcgccgtg      540

ggtgaggcca gcatctgcga ggatgactgg aattccgggg agaggttcac gtgcaccgtg      600

acccacacag acctgccctc gccactgaag cagaccatct cccggcccaa gggggtggcc      660

ctgcacaggc ccgatgtcta cttgctgcca ccagcccggg agcagctgaa cctgcgggag      720

tcggccacca tcacgtgcct ggtgacgggc ttctctcccg cggacgtctt cgtgcagtgg      780

atgcagaggg ggcagccctt gtccccggag aagtatgtga ccagcgcccc aatgcctgag      840

ccccaggccc caggccggta cttcgcccac agcatcctga ccgtgtccga agaggaatgg      900

aacacggggg agacctacac ctgcgtggtg gcccatgagg ccctgcccaa cagggtcacc      960

gagaggaccg tggacaagtc caccggtaaa cccaccctgt acaacgtgtc cctggtcatg     1020

tccgacacag ctggcacctg ctac                                            1044


<210>  19
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  kappa light chain constant region polypeptide

<400>  19
cggaccgtgg ccgcccccag cgtgttcatc ttccctccca gcgacgagca gctgaagtct       60

ggcaccgcca gcgtggtgtg cctgctgaac aacttctacc cccgcgaggc caaggtgcag      120

tggaaggtgg acaacgccct gcagagcggc aacagccagg agagcgtgac cgagcaggac      180

tccaaggaca gcacctacag cctgagcagc accctgaccc tgagcaaggc cgactacgag      240

aagcacaagg tgtacgcctg cgaggtgacc caccagggac tgtctagccc cgtgaccaag      300

agcttcaacc ggggcgagtg c                                                321


<210>  20
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Shorter RBD polypeptide (319-541)

<400>  20
agggtgcagc ccacggagag catcgtgagg tttcccaata taaccaacct ttgccccttc       60

ggggaagtct tcaatgccac ccggttcgca agcgtctacg cctggaacag gaagaggatc      120

tcaaactgcg tggccgacta tagcgtcctc tacaattcag catctttctc cactttcaaa      180

tgctacggcg ttagccccac caagctgaac gatctgtgtt ttaccaatgt gtacgccgat      240

agcttcgtca ttaggggtga cgaggtgagg cagattgcgc caggccagac cggcaagatc      300

gccgattaca actacaagtt gccggacgac tttaccggtt gcgttatcgc ctggaacagc      360

aacaatctgg acagcaaggt gggcggcaat tacaattacc tgtaccgact cttcaggaag      420

agcaacctga aacccttcga gagggacatc agcaccgaaa tctaccaggc cggcagcact      480

ccctgcaacg gggttgaggg gttcaactgc tacttcccgc tccagtcata cggcttccaa      540

ccaacaaacg gcgtagggta ccagccctac agggtggtgg tactgagctt cgaactcttg      600

cacgcacccg caacggtgtg cggaccgaag aagagtacca acttggtgaa gaacaagtgc      660

gtaaacttc                                                              669


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycine/Serine Linker

<400>  21

Gly Gly Ser Gly Gly 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycine/Serine Linker

<400>  22

Gly Ser Gly Gly Ser 
1               5   


<210>  23
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  23

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  24
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  24

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  25
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  25

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  26
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  26

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  27
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  27

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  28
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  28

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  29
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  29

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  30
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  30

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Gln Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  31
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  31

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  32
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  32

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  33
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  33

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser 
                165                 170                 175     


Tyr Gly Phe Arg Pro Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  34
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  34

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Asp Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Leu Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Val Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser 
                165                 170                 175     


Tyr Ser Phe Arg Pro Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Lys Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


<210>  35
<211>  273
<212>  PRT
<213>  SARS-CoV-2

<400>  35

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Asp Glu Val Phe Asn Ala Thr Lys Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Leu Ala Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Lys Leu Asp Ser Lys Val Ser 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys 
145                 150                 155                 160 


Pro Cys Asn Gly Val Ala Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser 
                165                 170                 175     


Tyr Ser Phe Arg Pro Thr Tyr Gly Val Gly His Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    210                 215                 220                 


Phe Asn Gly Leu Lys Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
225                 230                 235                 240 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                245                 250                 255     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            260                 265                 270         


Ser 
    


