                         SEQUENCE LISTING

<110>  Monte Rosa Therapeutics, Inc.
 
<120>  E3 LIGASE FUSION PROTEINS FOR PROXIMITY DETECTION

<130>  52271-0002WO1

<140>  PCT/US2022/032117
<141>  2022-06-03

<150>  US 63/197,195
<151>  2021-06-04

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  764
<212>  PRT
<213>  Artificial

<220>
<223>  TurboID CRBN fusion protein

<400>  1

Met Lys Asp Asn Thr Val Pro Leu Lys Leu Ile Ala Leu Leu Ala Asn 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Thr Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile 
    50                  55                  60                  


Pro Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly Ser 
65                  70                  75                  80  


Val Ala Val Leu Pro Val Val Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Ser Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Lys Arg Gly Pro Ala 
    130                 135                 140                 


Ala Ile Gly Leu Gly Pro Val Ile Gly Ile Val Met Ala Glu Ala Leu 
145                 150                 155                 160 


Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp Leu 
                165                 170                 175     


Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Ala Gly 
            180                 185                 190         


Ile Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn Val 
        195                 200                 205             


Ala Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile Thr 
    210                 215                 220                 


Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala Thr 
225                 230                 235                 240 


Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu Gly 
                245                 250                 255     


Leu Ala Pro Tyr Leu Pro Arg Trp Glu Lys Leu Asp Asn Phe Ile Asn 
            260                 265                 270         


Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile Ser 
        275                 280                 285             


Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly Val 
    290                 295                 300                 


Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu Lys 
305                 310                 315                 320 


Gly Ser Gly Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met 
                325                 330                 335     


Gly Asn His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu 
            340                 345                 350         


Met Glu Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile 
        355                 360                 365             


Ile Asn Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala 
    370                 375                 380                 


Asp Met Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys 
385                 390                 395                 400 


Gln Val Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly 
                405                 410                 415     


Gln Thr Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val 
            420                 425                 430         


Arg Asn Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser 
        435                 440                 445             


Asn Val Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr 
    450                 455                 460                 


Ala Tyr Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys 
465                 470                 475                 480 


Ala Ile Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser 
                485                 490                 495     


Asp Gly Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu 
            500                 505                 510         


Pro Ser Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln 
        515                 520                 525             


Ile Phe Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys 
    530                 535                 540                 


Trp Trp Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr 
545                 550                 555                 560 


Ser Trp Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met 
                565                 570                 575     


Asp Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp 
            580                 585                 590         


Asp Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala 
        595                 600                 605             


Cys Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly 
    610                 615                 620                 


Ser Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys 
625                 630                 635                 640 


Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys 
                645                 650                 655     


Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val 
            660                 665                 670         


Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys 
        675                 680                 685             


Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro 
    690                 695                 700                 


Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile 
705                 710                 715                 720 


Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe 
                725                 730                 735     


Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu 
            740                 745                 750         


Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        755                 760                 


<210>  2
<211>  1021
<212>  PRT
<213>  Artificial

<220>
<223>  TurboID CRBN fusion protein with T2A and GFP

<400>  2

Met Lys Asp Asn Thr Val Pro Leu Lys Leu Ile Ala Leu Leu Ala Asn 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Thr Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile 
    50                  55                  60                  


Pro Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly Ser 
65                  70                  75                  80  


Val Ala Val Leu Pro Val Val Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Ser Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Lys Arg Gly Pro Ala 
    130                 135                 140                 


Ala Ile Gly Leu Gly Pro Val Ile Gly Ile Val Met Ala Glu Ala Leu 
145                 150                 155                 160 


Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp Leu 
                165                 170                 175     


Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Ala Gly 
            180                 185                 190         


Ile Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn Val 
        195                 200                 205             


Ala Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile Thr 
    210                 215                 220                 


Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala Thr 
225                 230                 235                 240 


Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu Gly 
                245                 250                 255     


Leu Ala Pro Tyr Leu Pro Arg Trp Glu Lys Leu Asp Asn Phe Ile Asn 
            260                 265                 270         


Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile Ser 
        275                 280                 285             


Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly Val 
    290                 295                 300                 


Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu Lys 
305                 310                 315                 320 


Gly Ser Gly Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met 
                325                 330                 335     


Gly Asn His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu 
            340                 345                 350         


Met Glu Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile 
        355                 360                 365             


Ile Asn Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala 
    370                 375                 380                 


Asp Met Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys 
385                 390                 395                 400 


Gln Val Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly 
                405                 410                 415     


Gln Thr Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val 
            420                 425                 430         


Arg Asn Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser 
        435                 440                 445             


Asn Val Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr 
    450                 455                 460                 


Ala Tyr Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys 
465                 470                 475                 480 


Ala Ile Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser 
                485                 490                 495     


Asp Gly Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu 
            500                 505                 510         


Pro Ser Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln 
        515                 520                 525             


Ile Phe Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys 
    530                 535                 540                 


Trp Trp Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr 
545                 550                 555                 560 


Ser Trp Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met 
                565                 570                 575     


Asp Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp 
            580                 585                 590         


Asp Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala 
        595                 600                 605             


Cys Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly 
    610                 615                 620                 


Ser Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys 
625                 630                 635                 640 


Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys 
                645                 650                 655     


Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val 
            660                 665                 670         


Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys 
        675                 680                 685             


Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro 
    690                 695                 700                 


Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile 
705                 710                 715                 720 


Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe 
                725                 730                 735     


Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu 
            740                 745                 750         


Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu Glu Gly Arg Gly 
        755                 760                 765             


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
    770                 775                 780                 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
785                 790                 795                 800 


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
                805                 810                 815     


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
            820                 825                 830         


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
        835                 840                 845             


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
    850                 855                 860                 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
865                 870                 875                 880 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
                885                 890                 895     


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
            900                 905                 910         


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
        915                 920                 925             


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
    930                 935                 940                 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
945                 950                 955                 960 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
                965                 970                 975     


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
            980                 985                 990         


Asp Pro Asn Glu Lys Arg Asp His  Met Val Leu Leu Glu  Phe Val Thr 
        995                 1000                 1005             


Ala Ala  Gly Ile Thr Leu Gly  Met Asp Glu Leu Tyr  Lys 
    1010                 1015                 1020     


<210>  3
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Glu Ser Glu Glu Glu Asp Glu Met Glu Val 
            20                  25                  30          


Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn Phe 
        35                  40                  45              


Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met Glu 
    50                  55                  60                  


Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val Ile 
65                  70                  75                  80  


Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr Leu 
                85                  90                  95      


Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn Leu 
            100                 105                 110         


Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val Gln 
        115                 120                 125             


Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr Arg 
    130                 135                 140                 


Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile Gly 
145                 150                 155                 160 


Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly Ile 
                165                 170                 175     


Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr 
            180                 185                 190         


Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro 
        195                 200                 205             


Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln 
    210                 215                 220                 


Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro 
225                 230                 235                 240 


Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile 
                245                 250                 255     


Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu 
            260                 265                 270         


Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro 
        275                 280                 285             


Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile 
    290                 295                 300                 


Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu 
305                 310                 315                 320 


Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile 
                325                 330                 335     


Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His 
            340                 345                 350         


Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn 
        355                 360                 365             


Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala 
    370                 375                 380                 


Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys 
385                 390                 395                 400 


Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu 
                405                 410                 415     


Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile 
            420                 425                 430         


Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440     


<210>  4
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  5
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln 
1               5                   10                  15      


Val Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln 
            20                  25                  30          


Thr Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg 
        35                  40                  45              


Asn Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn 
    50                  55                  60                  


Val Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala 
65                  70                  75                  80  


Tyr Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala 
                85                  90                  95      


Ile Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp 
            100                 105                 110         


Gly Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro 
        115                 120                 125             


Ser Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile 
    130                 135                 140                 


Phe Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp 
145                 150                 155                 160 


Trp Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser 
                165                 170                 175     


Trp Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp 
            180                 185                 190         


Arg Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp 
        195                 200                 205             


Ser Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys 
    210                 215                 220                 


Leu Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser 
225                 230                 235                 240 


Ala Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr 
                245                 250                 255     


Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn 
            260                 265                 270         


Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn 
        275                 280                 285             


Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn 
    290                 295                 300                 


Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly 
305                 310                 315                 320 


Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly 
                325                 330                 335     


Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp 
            340                 345                 350         


Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp 
        355                 360                 365             


Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
    370                 375                 


<210>  6
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Arg Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser 
            340                 345                 350         


His Ile Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln 
        355                 360                 365             


Lys Phe Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp 
    370                 375                 380                 


Thr Glu Asp Glu Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
385                 390                 395             


<210>  7
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Leu Gln His Leu Leu Lys Met Ile Phe Arg Ile Gln Gln Ala 
1               5                   10                  15      


Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr Met Ser Ala 
            20                  25                  30          


Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro Ser Lys Pro 
        35                  40                  45              


Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln Lys Tyr Gln 
    50                  55                  60                  


Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro Arg Trp Leu 
65                  70                  75                  80  


Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile Lys Lys Gln 
                85                  90                  95      


Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu Pro Ser Asn 
            100                 105                 110         


Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro Ile Asp Asp 
        115                 120                 125             


Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile Gln Arg Leu 
    130                 135                 140                 


Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu Cys Cys Lys 
145                 150                 155                 160 


Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile Phe Ser Leu 
                165                 170                 175     


Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val 
            180                 185                 190         


His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly 
        195                 200                 205             


Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val 
    210                 215                 220                 


Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala 
225                 230                 235                 240 


Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser 
                245                 250                 255     


Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp 
            260                 265                 270         


Lys Val Ile Leu Cys Leu 
        275             


<210>  8
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Leu Gln His Leu Leu Lys Met Ile Phe Arg Ile Gln Gln Ala 
1               5                   10                  15      


Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser Thr Met Ser Ala 
            20                  25                  30          


Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe Pro Ser Lys Pro 
        35                  40                  45              


Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp Gln Lys Tyr Gln 
    50                  55                  60                  


Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp Pro Arg Trp Leu 
65                  70                  75                  80  


Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg Ile Lys Lys Gln 
                85                  90                  95      


Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser Leu Pro Ser Asn 
            100                 105                 110         


Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu Pro Ile Asp Asp 
        115                 120                 125             


Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala Ile Gln Arg Leu 
    130                 135                 140                 


Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser Leu Cys Cys Lys 
145                 150                 155                 160 


Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu Ile Phe Ser Leu 
                165                 170                 175     


Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro His Gly Tyr Val 
            180                 185                 190         


His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu Asn Leu Ile Gly 
        195                 200                 205             


Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr Ala Trp Thr Val 
    210                 215                 220                 


Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp Lys Phe Thr Ala 
225                 230                 235                 240 


Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly Leu Thr Arg Ser 
                245                 250                 255     


Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu Ile Ser Pro Asp 
            260                 265                 270         


Lys Val Ile Leu Cys Leu 
        275             


<210>  9
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Val Tyr Phe Pro Leu Leu 
        275                 280                 


<210>  10
<211>  3094
<212>  DNA
<213>  Artificial

<220>
<223>  TurboID CRBN vector GOI region

<400>  10
tcgctagcgc cgccaccatg aaagacaata ctgtgcctct gaagctgatc gctctcctgg       60

ctaatggcga gttccatagt ggcgaacagc tgggagaaac cctgggcatg tccagggccg      120

ctatcaacaa gcacattcag actctgcgcg actggggcgt ggacgtgttc accgtgcccg      180

gaaagggcta ctctctgccc gagcctatcc cgctgctgaa cgctaaacag attctgggac      240

agctggacgg cgggagcgtg gcagtcctgc ctgtggtcga ctccaccaat cagtacctgc      300

tggatcgaat cggcgagctg aagagtgggg atgcttgcat tgcagaatat cagcaggcag      360

ggagaggaag cagagggagg aaatggttct ctccttttgg agctaacctg tacctgagta      420

tgttttggcg cctgaagcgg ggaccagcag caatcggcct gggcccggtc atcggaattg      480

tcatggcaga agcgctgcga aagctgggag cagacaaggt gcgagtcaaa tggcccaatg      540

acctgtatct gcaggataga aagctggcag gcatcctggt ggagctggcc ggaataacag      600

gcgatgctgc acagatcgtc attggcgccg ggattaacgt ggctatgagg cgcgtggagg      660

aaagcgtggt caatcagggc tggatcacac tgcaggaagc agggattaac ctggacagga      720

atactctggc cgctacgctg atccgagagc tgcgggcagc cctggaactg ttcgagcagg      780

aaggcctggc tccatatctg ccacggtggg agaagctgga taacttcatc aatagacccg      840

tgaagctgat cattggggac aaagagattt tcgggattag ccgggggatt gataaacagg      900

gagccctgct gctggaacag gacggagtta tcaaaccctg gatgggcgga gaaatcagtc      960

tgcggtctgc cgaaaagggt tctggagccg gcgagggcga ccagcaggat gccgctcata     1020

acatgggcaa ccatctgcct ctgctgcccg cagagagcga agaagaggac gagatggaag     1080

tggaagatca ggacagcaaa gaggccaaga agcccaacat catcaacttc gacaccagcc     1140

tgcctaccag ccacacatat ctgggcgccg acatggaaga gttccacggc agaaccctgc     1200

acgacgatga cagctgccaa gtgatccccg tgctgcccca agtcatgatg attctgatcc     1260

ccggccagac actgcccctg cagctgtttc atcctcaaga ggtgtccatg gtccgaaacc     1320

tgatccagaa ggaccggacc tttgccgtgc tggcctacag caacgtgcaa gagagagagg     1380

cccagtttgg caccaccgcc gagatctacg cctacagaga ggaacaggac ttcggcatcg     1440

agatcgtgaa agtgaaggcc atcggccggc agcggttcaa ggttctggaa ctgagaaccc     1500

agagcgacgg catccagcag gccaaggttc agatcctgcc tgagtgtgtg ctgcccagca     1560

caatgtctgc cgtgcagctg gaaagcctga acaagtgcca gatcttcccc agcaagcccg     1620

tgtccagaga agatcagtgc agctacaagt ggtggcagaa gtaccagaag cggaagttcc     1680

actgcgccaa cctgaccagc tggcccagat ggctgtactc cctgtacgat gccgagacac     1740

tgatggaccg gatcaaaaag cagctgagag agtgggacga gaacctgaag gacgactccc     1800

tgcctagcaa ccccatcgac ttcagctata gagtggccgc ctgcctgcct atcgacgacg     1860

tgctgagaat ccagctgctg aagatcggca gcgccatcca gagactgaga tgcgagctgg     1920

acatcatgaa caaatgtacc agcctgtgct gcaagcagtg ccaagagaca gagatcacca     1980

ccaagaacga gatctttagc ctgagcctgt gcggccctat ggccgcctat gtgaatcctc     2040

acggctacgt gcacgaaacc ctgaccgtgt acaaggcctg caacctgaac ctgatcggca     2100

gacctagcac cgagcacagc tggtttccag gatacgcctg gacagtggcc cagtgcaaga     2160

tctgtgcctc tcacatcggc tggaagttca ccgccaccaa aaaggacatg agccctcaga     2220

agttctgggg cctgaccaga agtgccctgc tgcctacaat ccccgacacc gaggatgaga     2280

tcagccccga caaagtgatc ctgtgcctgg aaggcagggg ttctctgctg acctgcggag     2340

atgtcgaaga aaatcccgga ccaatggtgt ccaagggcga agaactgttt accggcgtgg     2400

tgcccatcct ggtggaactg gatggggacg tgaacggaca caagttcagc gttagcggag     2460

aaggcgaagg cgacgccaca tacggaaagc tgaccctgaa gttcatctgc accaccggca     2520

agctgcctgt gccttggcct acactggtca ccacactgac atacggcgtg cagtgcttca     2580

gcagatatcc cgaccatatg aagcagcacg acttcttcaa gagcgccatg cctgagggct     2640

acgtgcaaga gcggaccatc ttctttaagg acgacggcaa ctacaagacc agggccgaag     2700

tgaagttcga gggcgacacc ctggtcaacc ggatcgagct gaagggcatc gacttcaaag     2760

aggacggcaa catcctggga cacaagctcg agtacaatta caactcccac aacgtgtaca     2820

tcatggccga caagcagaaa aacggcatca aagtcaactt caagattcgg cacaacatcg     2880

aggacggctc cgtgcagctg gccgatcatt atcagcagaa cacccctatc ggcgacggcc     2940

cagttctgct gcccgataat cactacctgt ccactcagtc tgccctgagc aaggacccca     3000

acgagaagag ggatcacatg gtgctgctcg agtttgtgac cgccgctggc atcacactcg     3060

gcatggatga gctgtacaag tgaatctaga agtt                                 3094


<210>  11
<211>  2292
<212>  DNA
<213>  Artificial

<220>
<223>  TurboID CRBN fusion protein polynucleotide sequence

<400>  11
atgaaagaca atactgtgcc tctgaagctg atcgctctcc tggctaatgg cgagttccat       60

agtggcgaac agctgggaga aaccctgggc atgtccaggg ccgctatcaa caagcacatt      120

cagactctgc gcgactgggg cgtggacgtg ttcaccgtgc ccggaaaggg ctactctctg      180

cccgagccta tcccgctgct gaacgctaaa cagattctgg gacagctgga cggcgggagc      240

gtggcagtcc tgcctgtggt cgactccacc aatcagtacc tgctggatcg aatcggcgag      300

ctgaagagtg gggatgcttg cattgcagaa tatcagcagg cagggagagg aagcagaggg      360

aggaaatggt tctctccttt tggagctaac ctgtacctga gtatgttttg gcgcctgaag      420

cggggaccag cagcaatcgg cctgggcccg gtcatcggaa ttgtcatggc agaagcgctg      480

cgaaagctgg gagcagacaa ggtgcgagtc aaatggccca atgacctgta tctgcaggat      540

agaaagctgg caggcatcct ggtggagctg gccggaataa caggcgatgc tgcacagatc      600

gtcattggcg ccgggattaa cgtggctatg aggcgcgtgg aggaaagcgt ggtcaatcag      660

ggctggatca cactgcagga agcagggatt aacctggaca ggaatactct ggccgctacg      720

ctgatccgag agctgcgggc agccctggaa ctgttcgagc aggaaggcct ggctccatat      780

ctgccacggt gggagaagct ggataacttc atcaatagac ccgtgaagct gatcattggg      840

gacaaagaga ttttcgggat tagccggggg attgataaac agggagccct gctgctggaa      900

caggacggag ttatcaaacc ctggatgggc ggagaaatca gtctgcggtc tgccgaaaag      960

ggttctggag ccggcgaggg cgaccagcag gatgccgctc ataacatggg caaccatctg     1020

cctctgctgc ccgcagagag cgaagaagag gacgagatgg aagtggaaga tcaggacagc     1080

aaagaggcca agaagcccaa catcatcaac ttcgacacca gcctgcctac cagccacaca     1140

tatctgggcg ccgacatgga agagttccac ggcagaaccc tgcacgacga tgacagctgc     1200

caagtgatcc ccgtgctgcc ccaagtcatg atgattctga tccccggcca gacactgccc     1260

ctgcagctgt ttcatcctca agaggtgtcc atggtccgaa acctgatcca gaaggaccgg     1320

acctttgccg tgctggccta cagcaacgtg caagagagag aggcccagtt tggcaccacc     1380

gccgagatct acgcctacag agaggaacag gacttcggca tcgagatcgt gaaagtgaag     1440

gccatcggcc ggcagcggtt caaggttctg gaactgagaa cccagagcga cggcatccag     1500

caggccaagg ttcagatcct gcctgagtgt gtgctgccca gcacaatgtc tgccgtgcag     1560

ctggaaagcc tgaacaagtg ccagatcttc cccagcaagc ccgtgtccag agaagatcag     1620

tgcagctaca agtggtggca gaagtaccag aagcggaagt tccactgcgc caacctgacc     1680

agctggccca gatggctgta ctccctgtac gatgccgaga cactgatgga ccggatcaaa     1740

aagcagctga gagagtggga cgagaacctg aaggacgact ccctgcctag caaccccatc     1800

gacttcagct atagagtggc cgcctgcctg cctatcgacg acgtgctgag aatccagctg     1860

ctgaagatcg gcagcgccat ccagagactg agatgcgagc tggacatcat gaacaaatgt     1920

accagcctgt gctgcaagca gtgccaagag acagagatca ccaccaagaa cgagatcttt     1980

agcctgagcc tgtgcggccc tatggccgcc tatgtgaatc ctcacggcta cgtgcacgaa     2040

accctgaccg tgtacaaggc ctgcaacctg aacctgatcg gcagacctag caccgagcac     2100

agctggtttc caggatacgc ctggacagtg gcccagtgca agatctgtgc ctctcacatc     2160

ggctggaagt tcaccgccac caaaaaggac atgagccctc agaagttctg gggcctgacc     2220

agaagtgccc tgctgcctac aatccccgac accgaggatg agatcagccc cgacaaagtg     2280

atcctgtgcc tg                                                         2292


<210>  12
<211>  3066
<212>  DNA
<213>  Artificial

<220>
<223>  TurboID CRBN fusion protein with T2A and GFP polynucleotide 
       sequence

<400>  12
atgaaagaca atactgtgcc tctgaagctg atcgctctcc tggctaatgg cgagttccat       60

agtggcgaac agctgggaga aaccctgggc atgtccaggg ccgctatcaa caagcacatt      120

cagactctgc gcgactgggg cgtggacgtg ttcaccgtgc ccggaaaggg ctactctctg      180

cccgagccta tcccgctgct gaacgctaaa cagattctgg gacagctgga cggcgggagc      240

gtggcagtcc tgcctgtggt cgactccacc aatcagtacc tgctggatcg aatcggcgag      300

ctgaagagtg gggatgcttg cattgcagaa tatcagcagg cagggagagg aagcagaggg      360

aggaaatggt tctctccttt tggagctaac ctgtacctga gtatgttttg gcgcctgaag      420

cggggaccag cagcaatcgg cctgggcccg gtcatcggaa ttgtcatggc agaagcgctg      480

cgaaagctgg gagcagacaa ggtgcgagtc aaatggccca atgacctgta tctgcaggat      540

agaaagctgg caggcatcct ggtggagctg gccggaataa caggcgatgc tgcacagatc      600

gtcattggcg ccgggattaa cgtggctatg aggcgcgtgg aggaaagcgt ggtcaatcag      660

ggctggatca cactgcagga agcagggatt aacctggaca ggaatactct ggccgctacg      720

ctgatccgag agctgcgggc agccctggaa ctgttcgagc aggaaggcct ggctccatat      780

ctgccacggt gggagaagct ggataacttc atcaatagac ccgtgaagct gatcattggg      840

gacaaagaga ttttcgggat tagccggggg attgataaac agggagccct gctgctggaa      900

caggacggag ttatcaaacc ctggatgggc ggagaaatca gtctgcggtc tgccgaaaag      960

ggttctggag ccggcgaggg cgaccagcag gatgccgctc ataacatggg caaccatctg     1020

cctctgctgc ccgcagagag cgaagaagag gacgagatgg aagtggaaga tcaggacagc     1080

aaagaggcca agaagcccaa catcatcaac ttcgacacca gcctgcctac cagccacaca     1140

tatctgggcg ccgacatgga agagttccac ggcagaaccc tgcacgacga tgacagctgc     1200

caagtgatcc ccgtgctgcc ccaagtcatg atgattctga tccccggcca gacactgccc     1260

ctgcagctgt ttcatcctca agaggtgtcc atggtccgaa acctgatcca gaaggaccgg     1320

acctttgccg tgctggccta cagcaacgtg caagagagag aggcccagtt tggcaccacc     1380

gccgagatct acgcctacag agaggaacag gacttcggca tcgagatcgt gaaagtgaag     1440

gccatcggcc ggcagcggtt caaggttctg gaactgagaa cccagagcga cggcatccag     1500

caggccaagg ttcagatcct gcctgagtgt gtgctgccca gcacaatgtc tgccgtgcag     1560

ctggaaagcc tgaacaagtg ccagatcttc cccagcaagc ccgtgtccag agaagatcag     1620

tgcagctaca agtggtggca gaagtaccag aagcggaagt tccactgcgc caacctgacc     1680

agctggccca gatggctgta ctccctgtac gatgccgaga cactgatgga ccggatcaaa     1740

aagcagctga gagagtggga cgagaacctg aaggacgact ccctgcctag caaccccatc     1800

gacttcagct atagagtggc cgcctgcctg cctatcgacg acgtgctgag aatccagctg     1860

ctgaagatcg gcagcgccat ccagagactg agatgcgagc tggacatcat gaacaaatgt     1920

accagcctgt gctgcaagca gtgccaagag acagagatca ccaccaagaa cgagatcttt     1980

agcctgagcc tgtgcggccc tatggccgcc tatgtgaatc ctcacggcta cgtgcacgaa     2040

accctgaccg tgtacaaggc ctgcaacctg aacctgatcg gcagacctag caccgagcac     2100

agctggtttc caggatacgc ctggacagtg gcccagtgca agatctgtgc ctctcacatc     2160

ggctggaagt tcaccgccac caaaaaggac atgagccctc agaagttctg gggcctgacc     2220

agaagtgccc tgctgcctac aatccccgac accgaggatg agatcagccc cgacaaagtg     2280

atcctgtgcc tggaaggcag gggttctctg ctgacctgcg gagatgtcga agaaaatccc     2340

ggaccaatgg tgtccaaggg cgaagaactg tttaccggcg tggtgcccat cctggtggaa     2400

ctggatgggg acgtgaacgg acacaagttc agcgttagcg gagaaggcga aggcgacgcc     2460

acatacggaa agctgaccct gaagttcatc tgcaccaccg gcaagctgcc tgtgccttgg     2520

cctacactgg tcaccacact gacatacggc gtgcagtgct tcagcagata tcccgaccat     2580

atgaagcagc acgacttctt caagagcgcc atgcctgagg gctacgtgca agagcggacc     2640

atcttcttta aggacgacgg caactacaag accagggccg aagtgaagtt cgagggcgac     2700

accctggtca accggatcga gctgaagggc atcgacttca aagaggacgg caacatcctg     2760

ggacacaagc tcgagtacaa ttacaactcc cacaacgtgt acatcatggc cgacaagcag     2820

aaaaacggca tcaaagtcaa cttcaagatt cggcacaaca tcgaggacgg ctccgtgcag     2880

ctggccgatc attatcagca gaacacccct atcggcgacg gcccagttct gctgcccgat     2940

aatcactacc tgtccactca gtctgccctg agcaaggacc ccaacgagaa gagggatcac     3000

atggtgctgc tcgagtttgt gaccgccgct ggcatcacac tcggcatgga tgagctgtac     3060

aagtga                                                                3066


<210>  13
<211>  3094
<212>  DNA
<213>  Artificial

<220>
<223>  pcLV-CMV-MCS-T2A-eGFP-IRES-Puro GOI insert

<400>  13
tcgctagcgc cgccaccatg aaagacaata ctgtgcctct gaagctgatc gctctcctgg       60

ctaatggcga gttccatagt ggcgaacagc tgggagaaac cctgggcatg tccagggccg      120

ctatcaacaa gcacattcag actctgcgcg actggggcgt ggacgtgttc accgtgcccg      180

gaaagggcta ctctctgccc gagcctatcc cgctgctgaa cgctaaacag attctgggac      240

agctggacgg cgggagcgtg gcagtcctgc ctgtggtcga ctccaccaat cagtacctgc      300

tggatcgaat cggcgagctg aagagtgggg atgcttgcat tgcagaatat cagcaggcag      360

ggagaggaag cagagggagg aaatggttct ctccttttgg agctaacctg tacctgagta      420

tgttttggcg cctgaagcgg ggaccagcag caatcggcct gggcccggtc atcggaattg      480

tcatggcaga agcgctgcga aagctgggag cagacaaggt gcgagtcaaa tggcccaatg      540

acctgtatct gcaggataga aagctggcag gcatcctggt ggagctggcc ggaataacag      600

gcgatgctgc acagatcgtc attggcgccg ggattaacgt ggctatgagg cgcgtggagg      660

aaagcgtggt caatcagggc tggatcacac tgcaggaagc agggattaac ctggacagga      720

atactctggc cgctacgctg atccgagagc tgcgggcagc cctggaactg ttcgagcagg      780

aaggcctggc tccatatctg ccacggtggg agaagctgga taacttcatc aatagacccg      840

tgaagctgat cattggggac aaagagattt tcgggattag ccgggggatt gataaacagg      900

gagccctgct gctggaacag gacggagtta tcaaaccctg gatgggcgga gaaatcagtc      960

tgcggtctgc cgaaaagggt tctggagccg gcgagggcga ccagcaggat gccgctcata     1020

acatgggcaa ccatctgcct ctgctgcccg cagagagcga agaagaggac gagatggaag     1080

tggaagatca ggacagcaaa gaggccaaga agcccaacat catcaacttc gacaccagcc     1140

tgcctaccag ccacacatat ctgggcgccg acatggaaga gttccacggc agaaccctgc     1200

acgacgatga cagctgccaa gtgatccccg tgctgcccca agtcatgatg attctgatcc     1260

ccggccagac actgcccctg cagctgtttc atcctcaaga ggtgtccatg gtccgaaacc     1320

tgatccagaa ggaccggacc tttgccgtgc tggcctacag caacgtgcaa gagagagagg     1380

cccagtttgg caccaccgcc gagatctacg cctacagaga ggaacaggac ttcggcatcg     1440

agatcgtgaa agtgaaggcc atcggccggc agcggttcaa ggttctggaa ctgagaaccc     1500

agagcgacgg catccagcag gccaaggttc agatcctgcc tgagtgtgtg ctgcccagca     1560

caatgtctgc cgtgcagctg gaaagcctga acaagtgcca gatcttcccc agcaagcccg     1620

tgtccagaga agatcagtgc agctacaagt ggtggcagaa gtaccagaag cggaagttcc     1680

actgcgccaa cctgaccagc tggcccagat ggctgtactc cctgtacgat gccgagacac     1740

tgatggaccg gatcaaaaag cagctgagag agtgggacga gaacctgaag gacgactccc     1800

tgcctagcaa ccccatcgac ttcagctata gagtggccgc ctgcctgcct atcgacgacg     1860

tgctgagaat ccagctgctg aagatcggca gcgccatcca gagactgaga tgcgagctgg     1920

acatcatgaa caaatgtacc agcctgtgct gcaagcagtg ccaagagaca gagatcacca     1980

ccaagaacga gatctttagc ctgagcctgt gcggccctat ggccgcctat gtgaatcctc     2040

acggctacgt gcacgaaacc ctgaccgtgt acaaggcctg caacctgaac ctgatcggca     2100

gacctagcac cgagcacagc tggtttccag gatacgcctg gacagtggcc cagtgcaaga     2160

tctgtgcctc tcacatcggc tggaagttca ccgccaccaa aaaggacatg agccctcaga     2220

agttctgggg cctgaccaga agtgccctgc tgcctacaat ccccgacacc gaggatgaga     2280

tcagccccga caaagtgatc ctgtgcctgg aaggcagggg ttctctgctg acctgcggag     2340

atgtcgaaga aaatcccgga ccaatggtgt ccaagggcga agaactgttt accggcgtgg     2400

tgcccatcct ggtggaactg gatggggacg tgaacggaca caagttcagc gttagcggag     2460

aaggcgaagg cgacgccaca tacggaaagc tgaccctgaa gttcatctgc accaccggca     2520

agctgcctgt gccttggcct acactggtca ccacactgac atacggcgtg cagtgcttca     2580

gcagatatcc cgaccatatg aagcagcacg acttcttcaa gagcgccatg cctgagggct     2640

acgtgcaaga gcggaccatc ttctttaagg acgacggcaa ctacaagacc agggccgaag     2700

tgaagttcga gggcgacacc ctggtcaacc ggatcgagct gaagggcatc gacttcaaag     2760

aggacggcaa catcctggga cacaagctcg agtacaatta caactcccac aacgtgtaca     2820

tcatggccga caagcagaaa aacggcatca aagtcaactt caagattcgg cacaacatcg     2880

aggacggctc cgtgcagctg gccgatcatt atcagcagaa cacccctatc ggcgacggcc     2940

cagttctgct gcccgataat cactacctgt ccactcagtc tgccctgagc aaggacccca     3000

acgagaagag ggatcacatg gtgctgctcg agtttgtgac cgccgctggc atcacactcg     3060

gcatggatga gctgtacaag tgaatctaga agtt                                 3094


<210>  14
<211>  321
<212>  PRT
<213>  Escherichia coli

<400>  14

Met Lys Asp Asn Thr Val Pro Leu Lys Leu Ile Ala Leu Leu Ala Asn 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Thr Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly Ser 
65                  70                  75                  80  


Val Ala Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Arg Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Glu Gln Gly Pro Ala 
    130                 135                 140                 


Ala Ala Ile Gly Leu Ser Leu Val Ile Gly Ile Val Met Ala Glu Val 
145                 150                 155                 160 


Leu Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Leu Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Thr 
            180                 185                 190         


Gly Lys Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn 
        195                 200                 205             


Met Ala Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile 
    210                 215                 220                 


Thr Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala 
225                 230                 235                 240 


Met Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu 
                245                 250                 255     


Gly Leu Ala Pro Tyr Leu Ser Arg Trp Glu Lys Leu Asp Asn Phe Ile 
            260                 265                 270         


Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile 
        275                 280                 285             


Ser Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
    290                 295                 300                 


Ile Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu 
305                 310                 315                 320 


Lys 
    


<210>  15
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  BioID2 amino acid

<400>  15

Phe Lys Asn Leu Ile Trp Leu Lys Glu Val Asp Ser Thr Gln Glu Arg 
1               5                   10                  15      


Leu Lys Glu Trp Asn Val Ser Tyr Gly Thr Ala Leu Val Ala Asp Arg 
            20                  25                  30          


Gln Thr Lys Gly Arg Gly Gly Leu Gly Arg Lys Trp Leu Ser Gln Glu 
        35                  40                  45              


Gly Gly Leu Tyr Phe Ser Phe Leu Leu Asn Pro Lys Glu Phe Glu Asn 
    50                  55                  60                  


Leu Leu Gln Leu Pro Leu Val Leu Gly Leu Ser Val Ser Glu Ala Leu 
65                  70                  75                  80  


Glu Glu Ile Thr Glu Ile Pro Phe Ser Leu Lys Trp Pro Asn Asp Val 
                85                  90                  95      


Tyr Phe Gln Glu Lys Lys Val Ser Gly Val Leu Cys Glu Leu Ser Lys 
            100                 105                 110         


Asp Lys Leu Ile Val Gly Ile Gly Ile Asn Val Asn Gln Arg Glu Ile 
        115                 120                 125             


Pro Glu Glu Ile Lys Asp Arg Ala Thr Thr Leu Tyr Glu Ile Thr Gly 
    130                 135                 140                 


Lys Asp Trp Asp Arg Lys Glu Val Leu Leu Lys Val Leu Lys Arg Ile 
145                 150                 155                 160 


Ser Glu Asn Leu Lys Lys Phe Lys Glu Lys Ser Phe Lys Glu Phe Lys 
                165                 170                 175     


Gly Lys Ile Glu Ser Lys Met Leu Tyr Leu Gly Glu Glu Val Lys Leu 
            180                 185                 190         


Leu Gly Glu Gly Lys Ile Thr Gly Lys Leu Val Gly Leu Ser Glu Lys 
        195                 200                 205             


Gly Gly Ala Leu Ile Leu Thr Glu Glu Gly Ile Lys Glu Ile Leu Ser 
    210                 215                 220                 


Gly Glu Phe Ser Leu Arg Arg Ser 
225                 230         


<210>  16
<211>  696
<212>  DNA
<213>  Artificial

<220>
<223>  BioID2 polynucleotide

<400>  16
ttcaagaacc tgatctggct gaaggaggtg gacagcaccc aggagagact gaaggagtgg       60

aacgtgagct acggcaccgc cctggtggcc gacagacaga ccaagggcag aggcggcctg      120

ggcagaaagt ggctgagcca ggagggcggc ctgtacttca gcttcctgct gaaccccaag      180

gagttcgaga acctgctgca gctgcccctg gtgctgggcc tgagcgtgag cgaggccctg      240

gaggagatca ccgagatccc cttcagcctg aagtggccca acgacgtgta cttccaggag      300

aagaaggtga gcggcgtgct gtgcgagctg agcaaggaca agctgatcgt gggcatcggc      360

atcaacgtga accagagaga gatccccgag gagatcaagg acagagccac caccctgtac      420

gagatcaccg gcaaggactg ggacagaaag gaggtgctgc tgaaggtgct gaagagaatc      480

agcgagaacc tgaagaagtt caaggagaag agcttcaagg agttcaaggg caagatcgag      540

agcaagatgc tgtacctggg cgaggaggtg aagctgctgg gcgagggcaa gatcaccggc      600

aagctggtgg gcctgagcga gaagggcggc gccctgatcc tgaccgagga gggcatcaag      660

gagatcctga gcggcgagtt cagcctgaga agaagc                                696


<210>  17
<211>  260
<212>  PRT
<213>  Artificial

<220>
<223>  BASU

<400>  17

Gly Lys Leu Ser Glu Ser Glu Ile Arg Phe Gly Leu Lys Thr Glu Val 
1               5                   10                  15      


Met Gly Gln His Leu Ile Tyr His Asp Val Leu Ser Ser Thr Gln Lys 
            20                  25                  30          


Thr Ala His Glu Leu Ala Asn Asn Asn Ala Pro Glu Gly Thr Leu Val 
        35                  40                  45              


Val Ala Asp Lys Gln Thr Ala Gly Arg Gly Gly Met Ser Arg Val Trp 
    50                  55                  60                  


His Ser Gln Glu Gly Asn Gly Val Trp Met Ser Leu Ile Leu Arg Pro 
65                  70                  75                  80  


Asp Ile Pro Leu Gln Lys Thr Pro Gln Leu Thr Leu Leu Ala Ala Val 
                85                  90                  95      


Ala Val Val Gln Gly Ile Glu Glu Ala Ala Gly Ile Gln Thr Asp Ile 
            100                 105                 110         


Lys Trp Pro Asn Asp Ile Leu Ile Asn Gly Lys Lys Thr Val Gly Ile 
        115                 120                 125             


Leu Thr Glu Met Gln Ala Glu Glu Asp Arg Val Arg Ser Val Ile Ile 
    130                 135                 140                 


Gly Ile Gly Ile Asn Val Asn Gln Gln Pro Asn Asp Phe Pro Asp Glu 
145                 150                 155                 160 


Leu Lys Asp Ile Ala Thr Ser Leu Ser Gln Ala Ala Gly Glu Lys Ile 
                165                 170                 175     


Asp Arg Ala Gly Val Ile Gln His Ile Leu Leu Cys Phe Glu Lys Arg 
            180                 185                 190         


Tyr Arg Asp Tyr Met Thr His Gly Phe Thr Pro Ile Lys Leu Leu Trp 
        195                 200                 205             


Glu Ser Tyr Ala Leu Gly Ile Gly Thr Asn Met Arg Ala Arg Thr Leu 
    210                 215                 220                 


Asn Gly Thr Phe Tyr Gly Lys Ala Leu Gly Ile Asp Asp Glu Gly Val 
225                 230                 235                 240 


Leu Leu Leu Glu Thr Asn Glu Gly Ile Lys Lys Ile Tyr Ser Ala Asp 
                245                 250                 255     


Ile Ser Leu Arg 
            260 


<210>  18
<211>  257
<212>  PRT
<213>  Artificial

<220>
<223>  miniTurbo amino acid

<400>  18

Ile Pro Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly 
1               5                   10                  15      


Ser Val Ala Val Leu Pro Val Val Asp Ser Thr Asn Gln Tyr Leu Leu 
            20                  25                  30          


Asp Arg Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr 
        35                  40                  45              


Gln Gln Ala Gly Arg Gly Ser Arg Gly Arg Lys Trp Phe Ser Pro Phe 
    50                  55                  60                  


Gly Ala Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Lys Arg Gly Pro 
65                  70                  75                  80  


Ala Ala Ile Gly Leu Gly Pro Val Ile Gly Ile Val Met Ala Glu Ala 
                85                  90                  95      


Leu Arg Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp 
            100                 105                 110         


Leu Tyr Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Ala 
        115                 120                 125             


Gly Ile Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn 
    130                 135                 140                 


Val Ala Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala 
                165                 170                 175     


Met Leu Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu 
            180                 185                 190         


Gly Leu Ala Pro Tyr Leu Ser Arg Trp Glu Lys Leu Asp Asn Phe Ile 
        195                 200                 205             


Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile 
    210                 215                 220                 


Ser Arg Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
225                 230                 235                 240 


Val Ile Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu 
                245                 250                 255     


Lys 
    


<210>  19
<211>  771
<212>  DNA
<213>  Artificial

<220>
<223>  miniTurbo polynucleotide

<400>  19
atcccgctgc tgaacgctaa acagattctg ggacagctgg acggcgggag cgtggcagtc       60

ctgcctgtgg tcgactccac caatcagtac ctgctggatc gaatcggcga gctgaagagt      120

ggggatgctt gcattgcaga atatcagcag gcagggagag gaagcagagg gaggaaatgg      180

ttctctcctt ttggagctaa cctgtacctg agtatgtttt ggcgcctgaa gcggggacca      240

gcagcaatcg gcctgggccc ggtcatcgga attgtcatgg cagaagcgct gcgaaagctg      300

ggagcagaca aggtgcgagt caaatggccc aatgacctgt atctgcagga tagaaagctg      360

gcaggcatcc tggtggagct ggccggaata acaggcgatg ctgcacagat cgtcattggc      420

gccgggatta acgtggctat gaggcgcgtg gaggaaagcg tggtcaatca gggctggatc      480

acactgcagg aagcagggat taacctggac aggaatactc tggccgctat gctgatccga      540

gagctgcggg cagccctgga actgttcgag caggaaggcc tggctccata tctgtcacgg      600

tgggagaagc tggataactt catcaataga cccgtgaagc tgatcattgg ggacaaagag      660

attttcggga ttagccgggg gattgataaa cagggagccc tgctgctgga acaggacgga      720

gttatcaaac cctggatggg cggagaaatc agtctgcggt ctgccgaaaa g               771


<210>  20
<211>  319
<212>  PRT
<213>  Artificial

<220>
<223>  20 turboID amino acid

<400>  20

Lys Asp Asn Thr Val Pro Leu Lys Leu Ile Ala Leu Leu Ala Asn Gly 
1               5                   10                  15      


Glu Phe His Ser Gly Glu Gln Leu Gly Glu Thr Leu Gly Met Ser Arg 
            20                  25                  30          


Ala Ala Ile Asn Lys His Ile Gln Thr Leu Arg Asp Trp Gly Val Asp 
        35                  40                  45              


Val Phe Thr Val Pro Gly Lys Gly Tyr Ser Leu Pro Glu Pro Ile Pro 
    50                  55                  60                  


Leu Leu Asn Ala Lys Gln Ile Leu Gly Gln Leu Asp Gly Gly Ser Val 
65                  70                  75                  80  


Ala Val Leu Pro Val Val Asp Ser Thr Asn Gln Tyr Leu Leu Asp Arg 
                85                  90                  95      


Ile Gly Glu Leu Lys Ser Gly Asp Ala Cys Ile Ala Glu Tyr Gln Gln 
            100                 105                 110         


Ala Gly Arg Gly Ser Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly Ala 
        115                 120                 125             


Asn Leu Tyr Leu Ser Met Phe Trp Arg Leu Lys Arg Gly Pro Ala Ala 
    130                 135                 140                 


Ile Gly Leu Gly Pro Val Ile Gly Ile Val Met Ala Glu Ala Leu Arg 
145                 150                 155                 160 


Lys Leu Gly Ala Asp Lys Val Arg Val Lys Trp Pro Asn Asp Leu Tyr 
                165                 170                 175     


Leu Gln Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Leu Ala Gly Ile 
            180                 185                 190         


Thr Gly Asp Ala Ala Gln Ile Val Ile Gly Ala Gly Ile Asn Val Ala 
        195                 200                 205             


Met Arg Arg Val Glu Glu Ser Val Val Asn Gln Gly Trp Ile Thr Leu 
    210                 215                 220                 


Gln Glu Ala Gly Ile Asn Leu Asp Arg Asn Thr Leu Ala Ala Thr Leu 
225                 230                 235                 240 


Ile Arg Glu Leu Arg Ala Ala Leu Glu Leu Phe Glu Gln Glu Gly Leu 
                245                 250                 255     


Ala Pro Tyr Leu Pro Arg Trp Glu Lys Leu Asp Asn Phe Ile Asn Arg 
            260                 265                 270         


Pro Val Lys Leu Ile Ile Gly Asp Lys Glu Ile Phe Gly Ile Ser Arg 
        275                 280                 285             


Gly Ile Asp Lys Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly Val Ile 
    290                 295                 300                 


Lys Pro Trp Met Gly Gly Glu Ile Ser Leu Arg Ser Ala Glu Lys 
305                 310                 315                 


<210>  21
<211>  957
<212>  DNA
<213>  Artificial

<220>
<223>  turboID polynucleotide

<400>  21
aaagacaata ctgtgcctct gaagctgatc gctctcctgg ctaatggcga gttccatagt       60

ggcgaacagc tgggagaaac cctgggcatg tccagggccg ctatcaacaa gcacattcag      120

actctgcgcg actggggcgt ggacgtgttc accgtgcccg gaaagggcta ctctctgccc      180

gagcctatcc cgctgctgaa cgctaaacag attctgggac agctggacgg cgggagcgtg      240

gcagtcctgc ctgtggtcga ctccaccaat cagtacctgc tggatcgaat cggcgagctg      300

aagagtgggg atgcttgcat tgcagaatat cagcaggcag ggagaggaag cagagggagg      360

aaatggttct ctccttttgg agctaacctg tacctgagta tgttttggcg cctgaagcgg      420

ggaccagcag caatcggcct gggcccggtc atcggaattg tcatggcaga agcgctgcga      480

aagctgggag cagacaaggt gcgagtcaaa tggcccaatg acctgtatct gcaggataga      540

aagctggcag gcatcctggt ggagctggcc ggaataacag gcgatgctgc acagatcgtc      600

attggcgccg ggattaacgt ggctatgagg cgcgtggagg aaagcgtggt caatcagggc      660

tggatcacac tgcaggaagc agggattaac ctggacagga atactctggc cgctacgctg      720

atccgagagc tgcgggcagc cctggaactg ttcgagcagg aaggcctggc tccatatctg      780

ccacggtggg agaagctgga taacttcatc aatagacccg tgaagctgat cattggggac      840

aaagagattt tcgggattag ccgggggatt gataaacagg gagccctgct gctggaacag      900

gacggagtta tcaaaccctg gatgggcgga gaaatcagtc tgcggtctgc cgaaaag         957


<210>  22
<211>  319
<212>  PRT
<213>  Artificial

<220>
<223>  AirID amino acid

<400>  22

Met Lys Asp Asn Thr Val Pro Leu Thr Leu Ile Ser Ile Leu Ala Asp 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Gln Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Lys Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Arg Val Gln Gly Lys Gly Tyr Cys Leu Pro Glu Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asp Glu Glu Lys Ile Arg Gln Gln Leu Asp Glu Gly Ser 
65                  70                  75                  80  


Val Thr Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Leu Asp Glu Leu Thr Ser Gly Asp Val Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Ser Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Tyr Trp Arg Leu Glu Gln Gly Pro Ala 
    130                 135                 140                 


Ala Ala Met Gly Leu Ser Leu Val Ile Gly Ile Val Met Ala Glu Thr 
145                 150                 155                 160 


Leu Gln Lys Leu Gly Ala Asp Gly Val Arg Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Leu Tyr Leu Asn Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Met Thr 
            180                 185                 190         


Gly Lys Thr Gly Asp Ala Ala His Ile Val Ile Gly Ala Gly Ile Asn 
        195                 200                 205             


Leu Ser Met Arg Glu Pro Glu Thr Asp Glu Val Asp Gln Ser Trp Ile 
    210                 215                 220                 


Asn Leu Gln Glu Ala Gly Ile Thr Ile Asp Arg Asn Gln Leu Ala Ala 
225                 230                 235                 240 


Arg Leu Ile Lys Asp Leu Arg Ser Ala Leu Arg Gln Phe Glu Gln Gln 
                245                 250                 255     


Gly Leu Ala Pro Phe Leu Ser Arg Trp Glu Ala Leu Asp Asn Phe Ile 
            260                 265                 270         


Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Arg Glu Ile His Gly Ile 
        275                 280                 285             


Ala Arg Gly Ile Asn Glu Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
    290                 295                 300                 


Val Ile Lys Pro Trp Ile Gly Gly Glu Ile Ser Leu Arg Ser Ala 
305                 310                 315                 


<210>  23
<211>  319
<212>  PRT
<213>  Artificial

<220>
<223>  AVVA amino acid

<400>  23

Met Ser Glu Gln Trp Ser Arg Lys Arg Glu Ile Leu Ala Leu Leu Ser 
1               5                   10                  15      


Ser Gly His Phe Val Ser Gly Glu Glu Leu Ala Thr Gln Leu Gly Ile 
            20                  25                  30          


Ser Arg Thr Ala Val Ser Lys His Ile Ala Ala Leu Glu Glu Tyr Gly 
        35                  40                  45              


Val Asp Ile Tyr Ser Val Lys Gly Lys Gly Tyr Lys Leu Ala Asn Pro 
    50                  55                  60                  


Ile Ser Leu Ile Asp Glu Ser Lys Leu Lys Ser Ala Ile Asn Asn Arg 
65                  70                  75                  80  


Cys Phe Tyr Phe Asp Glu Ile Pro Ser Thr Asn Gly Phe Met Leu Lys 
                85                  90                  95      


His Ala Glu Glu Leu Lys Ser Gly Asp Ile Cys Val Ala Glu Tyr Gln 
            100                 105                 110         


Ser Ala Gly Arg Gly Arg Arg Gly Arg Thr Trp Val Ser Pro Tyr Gly 
        115                 120                 125             


Cys His Leu Tyr Phe Ser Leu Tyr Trp Arg Phe Pro Gln Gly Met Ala 
    130                 135                 140                 


Gln Ala Met Gly Leu Ser Leu Val Val Ala Cys Ser Leu Val Lys Val 
145                 150                 155                 160 


Leu Lys Ser Phe Gly Val Asp Gly Val Gly Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Ile Tyr Leu Asn His Lys Lys Leu Ala Gly Val Leu Ile Glu Met Ser 
            180                 185                 190         


Gly Gln Ala Asp Ser Glu Cys His Leu Val Ile Gly Ile Gly Ile Asn 
        195                 200                 205             


Met Ala Met Ser Glu Gln Gln Gly Lys Lys Ile Asp Gln Pro Trp Ser 
    210                 215                 220                 


Asp Leu Ser Ser Leu Thr Ser Met Pro Asp Lys Thr Glu Leu Leu Ile 
225                 230                 235                 240 


Ala Leu Gln Lys Gln Leu Lys Gln Asp Leu Glu Leu Phe Glu Arg Glu 
                245                 250                 255     


Gly Leu Lys Ala Phe Gln Pro Arg Trp Gln Glu Ala Asp Leu Phe Tyr 
            260                 265                 270         


Gly Lys Gln Ile Lys Leu Leu Met Gly Glu Asn Gln Val Glu Gly Ile 
        275                 280                 285             


Cys Arg Gly Ile Asp Glu Gln Gly Ala Val Leu Leu Glu Thr Asp Asp 
    290                 295                 300                 


Gly Ile Gln Ala Phe Ile Gly Gly Glu Ile Ser Leu Arg Ala Ala 
305                 310                 315                 


<210>  24
<211>  957
<212>  DNA
<213>  Artificial

<220>
<223>  AVVA polynucleotide

<400>  24
atgtctgagc agtggtctag gaagagagag atccttgctc tcctcagctc tggacatttc       60

gtgtctggtg aggaacttgc tactcagctc ggaatctcta gaaccgctgt gagcaaacat      120

atcgctgccc ttgaagagta cggcgtggac atctatagcg tgaaaggtaa gggatacaag      180

ctcgcgaacc cgatctctct tatcgacgag tctaagctca agagcgccat caacaaccgt      240

tgcttctact tcgacgagat cccgtctacc aacggcttca tgcttaaaca cgctgaggaa      300

ctcaagtccg gggatatctg tgttgctgag taccagtctg ctggaagagg acgtagagga      360

agaacttggg tttcacctta cggatgccac ctctacttca gcctttattg gaggttcccg      420

caaggtatgg ctcaggctat gggactttct ctcgttgttg cttgcagcct cgttaaggtg      480

ctcaagtctt tcggagttga tggtgtggga gtgaagtggc ctaacgacat ctacctcaac      540

cataagaaac tcgccggtgt gctcatcgag atgtctggac aagctgattc tgagtgccat      600

ctcgttatcg gcatcgggat caacatggct atgtctgaac agcaggggaa gaagatcgat      660

cagccttggt ctgacctctc ctctctcact tctatgcctg acaagaccga gctgcttatc      720

gctctccaaa agcagcttaa gcaggacctc gagcttttcg agagagaggg acttaaggct      780

ttccagccta gatggcaaga ggctgatctc ttctacggga agcagatcaa gcttctcatg      840

ggagagaatc aggtcgaggg aatctgcaga ggaattgatg agcagggtgc tgttctcctc      900

gagactgatg atggaatcca ggcttttatc ggcggggaga tctctttgag agctgct         957


<210>  25
<211>  304
<212>  PRT
<213>  Artificial

<220>
<223>  AHLA amino acid

<400>  25

Met Arg Pro Phe Pro Leu Leu Arg Leu Leu Ser Asp Gly Glu Phe His 
1               5                   10                  15      


Ser Gly Gln Ala Leu Ala Glu Ala Leu Gly Val Ser Arg Ala Ser Ile 
            20                  25                  30          


Trp Asn Ala Leu Arg Asn Ala Glu Ala Leu Gly Val Asp Val His Ala 
        35                  40                  45              


Val Arg Gly Arg Gly Tyr Arg Leu Ser Glu Pro Leu Asp Trp Leu Asp 
    50                  55                  60                  


Glu Ala Ile Val Ala Arg His Leu Gly Glu Lys Ala Ser Phe Phe Asp 
65                  70                  75                  80  


Leu His Val Leu Asp Ser Val Asp Ser Thr Asn Thr Ala Leu Met Glu 
                85                  90                  95      


Arg Ala Leu Gln Gly Ala Pro His Gly Thr Cys Val Ala Ala Glu Arg 
            100                 105                 110         


Gln Thr Ala Gly Arg Gly Arg Arg Gly Arg Ala Trp His Ala Val Leu 
        115                 120                 125             


Gly Gly Ser Leu Thr Phe Ser Leu Leu Trp Arg Phe Asn Leu Gly Leu 
    130                 135                 140                 


Gly Ser Leu Ser Gly Leu Ser Leu Ala Val Gly Leu Ala Val Val Arg 
145                 150                 155                 160 


Ala Leu Asn Lys Leu Gly Val His Gly Ala Arg Leu Lys Trp Pro Asn 
                165                 170                 175     


Asp Val Leu Thr Asp Tyr Arg Lys Leu Ala Gly Ile Leu Ile Glu Leu 
            180                 185                 190         


Gln Gly Asp Met Leu Gly Pro Ala Ala Ala Val Ile Gly Ile Gly Leu 
        195                 200                 205             


Asn Val Arg Leu Ser Glu Ala Ala Arg Asn Ala Val Asp Gln Ala Val 
    210                 215                 220                 


Val Asp Leu His Ser Leu Cys Gly Ala Pro Ala Asp Arg Asn Thr Leu 
225                 230                 235                 240 


Leu Ala Asp Leu Leu Arg Glu Leu Ala Ala Met Leu Thr Ala Phe Glu 
                245                 250                 255     


Gln Asp Gly Phe Ala Pro Leu Arg Ala Glu Trp Glu Ala His His Ala 
            260                 265                 270         


Tyr Gln Asp Lys Ala Val Arg Leu Leu Leu Pro Asp Gly Ala Gly Val 
        275                 280                 285             


Gln Gly Val Ala Arg Gly Val Asp Glu Asp Gly Ala Leu Leu Leu Glu 
    290                 295                 300                 


<210>  26
<211>  969
<212>  DNA
<213>  Artificial

<220>
<223>  AHLA polynucleotide

<400>  26
atgaggcctt ttccgcttct cagactcttg tctgatgggg agttccattc tggacaagct       60

cttgctgaag ctctcggagt gtctagagct tctatctgga acgctctcag aaacgctgag      120

gctcttggag ttgatgtgca tgctgttaga ggacgtgggt acagactttc tgagcctctt      180

gattggctcg acgaggctat cgttgctaga catcttggag agaaggccag cttcttcgat      240

ctccatgttc tcgactctgt ggactctact aacacggctc tcatggaaag ggctctccaa      300

ggtgctcctc atggaacttg tgttgctgct gagagacaga ctgctggaag aggaagaaga      360

ggtagagctt ggcatgctgt gcttggagga tctcttacct tctctcttct ctggcgtttc      420

aacctcggac tcggatctct ttctggactc tctcttgctg ttggactcgc tgttgttagg      480

gctcttaaca agctcggagt gcatggtgct agactcaagt ggcctaacga tgtgctcacc      540

gattacagaa agctcgctgg aatcctcatc gagcttcagg gtgatatgct tggacctgct      600

gctgctgtta tcggaatcgg acttaacgtg agactctctg aggctgctag gaacgctgtt      660

gatcaggctg ttgtggatct ccattctctt tgtggtgctc cggctgatag aaataccctt      720

cttgctgatc tcctccgtga gcttgctgct atgcttactg ctttcgagca ggatggattc      780

gctcctctta gagctgaatg ggaagctcat cacgcttacc aggataaggc tgtgagactt      840

cttttgcctg atggtgctgg tgttcagggt gttgctagag gtgttgatga ggatggtgct      900

ttgctcctcg agactcaatc tggggagaga agattccaca gcggagagat ttctcttagg      960

cctgctgct                                                              969


<210>  27
<211>  319
<212>  PRT
<213>  Artificial

<220>
<223>  GFVA amino acid

<400>  27

Met Lys Asp Asn Thr Val Pro Leu Thr Leu Ile Ser Ile Leu Ala Asp 
1               5                   10                  15      


Gly Glu Phe His Ser Gly Glu Gln Leu Gly Glu Gln Leu Gly Met Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Lys Thr Leu Arg Asp Trp Gly Val 
        35                  40                  45              


Asp Val Phe Arg Val Gln Gly Lys Gly Tyr Cys Leu Pro Glu Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asp Glu Glu Lys Ile Arg Gln Gln Leu Asp Glu Gly Ser 
65                  70                  75                  80  


Val Thr Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp 
                85                  90                  95      


Arg Leu Asp Glu Leu Thr Ser Gly Asp Val Cys Ile Ala Glu Tyr Gln 
            100                 105                 110         


Gln Ala Gly Arg Gly Arg Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly 
        115                 120                 125             


Ala Asn Leu Tyr Leu Ser Met Tyr Trp Arg Leu Glu Gln Gly Pro Ala 
    130                 135                 140                 


Ala Ala Met Gly Leu Ser Leu Val Ile Gly Ile Val Met Ala Glu Thr 
145                 150                 155                 160 


Leu Gln Lys Leu Gly Ala Asp Gly Val Arg Val Lys Trp Pro Asn Asp 
                165                 170                 175     


Leu Tyr Leu Asn Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Met Thr 
            180                 185                 190         


Gly Lys Thr Gly Asp Ala Ala His Ile Val Ile Gly Ala Gly Ile Asn 
        195                 200                 205             


Leu Ser Met Arg Glu Pro Glu Thr Asp Glu Val Asp Gln Ser Trp Ile 
    210                 215                 220                 


Asn Leu Gln Glu Ala Gly Ile Thr Ile Asp Arg Asn Gln Leu Ala Ala 
225                 230                 235                 240 


Arg Leu Ile Lys Asp Leu Arg Ser Ala Leu Arg Gln Phe Glu Gln Gln 
                245                 250                 255     


Gly Leu Ala Pro Phe Leu Ser Arg Trp Glu Ala Leu Asp Asn Phe Ile 
            260                 265                 270         


Asn Arg Pro Val Lys Leu Ile Ile Gly Asp Arg Glu Ile His Gly Ile 
        275                 280                 285             


Ala Arg Gly Ile Asn Glu Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly 
    290                 295                 300                 


Val Ile Lys Pro Trp Ile Gly Gly Glu Ile Ser Leu Arg Ser Ala 
305                 310                 315                 


<210>  28
<211>  957
<212>  DNA
<213>  Artificial

<220>
<223>  GFVA polynucleotide

<400>  28
atgaaggaca acaccgttcc gctcacgctt atctctatcc ttgctgatgg tgagttccac       60

tctggtgaac aacttggaga gcagctcgga atgtctaggg ctgctattaa caagcacatc      120

aagaccctcc gtgactgggg agttgatgtg ttcagagttc aaggtaaggg gtactgcctt      180

cctgagccta tccaacttct cgacgaagag aagatcaggc agcagcttga tgagggatct      240

gttactgttc tcccggtgat cgattcgacc aaccagtacc ttctcgatag gctcgatgag      300

cttacctctg gtgatgtgtg tatcgctgag taccaacagg ctggaagagg acgtagaggt      360

aggaagtggt tttctccgtt cggagctaac ctctacctca gcatgtattg gagacttgag      420

caaggacctg ctgctgctat gggactttct ctcgttatcg gaatcgtgat ggctgagact      480

ctccaaaagc ttggagctga cggtgttaga gtgaagtggc ctaacgacct ttacctcaac      540

gataggaagc tcgctggaat cctcgttgag atgactggaa agactggtga cgctgctcat      600

atcgtgattg gagctggaat caacctctct atgcgtgagc ctgagactga tgaggttgac      660

cagtcttgga tcaacctcca agaggctggt atcaccatcg atagaaacca gcttgctgcc      720

aggctcatca aggatcttag atctgctctc aggcagttcg agcaacaagg acttgctcca      780

ttcctcagca gatgggaagc tctcgacaac ttcatcaaca ggccagtgaa gctcatcatc      840

ggtgatagag agatccacgg aatcgctagg ggaatcaacg aacaaggggc tcttttgctt      900

gagcaggacg gtgtgattaa gccttggatt ggaggtgaga tcagcctcag atctgct         957


<210>  29
<211>  318
<212>  PRT
<213>  Artificial

<220>
<223>  All amino acid

<400>  29

Met Lys Asp Lys Thr Arg Pro Leu Lys Leu Ile Ala Ile Leu Ala Asp 
1               5                   10                  15      


Gly Gln Phe His Ser Gly Glu Glu Leu Ala Thr Gln Leu Gly Ile Ser 
            20                  25                  30          


Arg Ala Ala Ile Asn Lys His Ile Lys Thr Leu Arg Glu Trp Gly Val 
        35                  40                  45              


Asp Val Phe Ser Val Gln Gly Lys Gly Tyr Cys Leu Ala Asn Pro Ile 
    50                  55                  60                  


Gln Leu Leu Asp Glu Thr Lys Ile Lys Gln Gln Leu Lys Asn Arg Val 
65                  70                  75                  80  


Thr Val Leu Pro Val Ile Asp Ser Thr Asn Gln Tyr Leu Leu Asp Arg 
                85                  90                  95      


Leu Asp Glu Leu Lys Ser Gly Asp Val Cys Val Ala Glu Tyr Gln Ser 
            100                 105                 110         


Ala Gly Arg Gly Arg Arg Gly Arg Lys Trp Phe Ser Pro Phe Gly Ser 
        115                 120                 125             


Asn Leu Tyr Phe Ser Met Tyr Trp Arg Leu Glu Gln Gly Met Ala Ala 
    130                 135                 140                 


Ala Met Gly Leu Ser Leu Val Val Gly Ile Val Met Ala Glu Val Leu 
145                 150                 155                 160 


Lys Lys Leu Gly Ala Asp Gly Val Arg Val Lys Trp Pro Asn Asp Leu 
                165                 170                 175     


Tyr Leu Asn Asp Arg Lys Leu Ala Gly Ile Leu Val Glu Met Thr Gly 
            180                 185                 190         


Lys Thr Gly Asp Ala Ala His Ile Val Ile Gly Ile Gly Ile Asn Leu 
        195                 200                 205             


Ser Met Ser Glu Pro Glu Thr Asn Glu Val Asp Gln Ser Trp Ala Asn 
    210                 215                 220                 


Leu Ser Asn Val Gly Ile Thr Ile Asp Arg Asn Gln Leu Val Ala Ser 
225                 230                 235                 240 


Leu Ala Lys Asp Leu Lys Ser Ala Leu Arg Gln Phe Glu Gln Gln Gly 
                245                 250                 255     


Leu Ala Ala Phe Leu Ser Arg Trp Gln Ala Leu Asp Asn Phe Ile Asn 
            260                 265                 270         


Arg Pro Val Lys Leu Leu Ile Gly Asp Lys Glu Ile His Gly Ile Ala 
        275                 280                 285             


Arg Gly Ile Asn Glu Gln Gly Ala Leu Leu Leu Glu Gln Asp Gly Gly 
    290                 295                 300                 


Ile Lys Ala Tyr Ile Gly Gly Glu Ile Ser Leu Arg Ser Ala 
305                 310                 315             


<210>  30
<211>  954
<212>  DNA
<213>  Artificial

<220>
<223>  All polynucleotide

<400>  30
atgaaggaca agaccagacc gctcaagctt atcgctatcc ttgctgatgg acagttccac       60

tctggtgagg aacttgctac tcagctcgga atttctaggg ccgctatcaa caagcacatc      120

aagactctcc gtgagtgggg agttgatgtg ttctctgttc aaggtaaggg gtactgcctc      180

gctaacccta tccaacttct cgacgagact aagatcaagc agcagctcaa gaacagggtg      240

acagttctcc ctgtgatcga ctctactaac cagtacctcc tcgataggct cgacgagctt      300

aagtctggtg atgtttgtgt ggccgagtac cagtctgctg gaagaggacg tagaggtagg      360

aagtggttta gcccgttcgg aagcaacctc tacttcagca tgtattggag gctcgagcaa      420

ggtatggctg ctgctatggg actttctctc gttgtgggaa tcgtgatggc tgaggtgctc      480

aagaagcttg gagctgacgg ggttagagtt aagtggccta acgatctcta cctcaacgac      540

agaaagctcg ctggaatcct cgttgagatg actggaaaga ctggtgacgc tgctcatatc      600

gtgatcggaa tcggtatcaa cctcagcatg tctgagcctg agactaacga ggttgaccag      660

tcttgggcta acctctctaa cgtgggaatc accatcgata ggaaccagct cgttgcttct      720

ctcgctaagg atctcaagtc tgctctcaga caattcgagc agcagggact tgctgctttc      780

ttgtctagat ggcaggctct cgacaacttc atcaacagac ctgtgaagct cctcatcggg      840

gacaaagaga ttcacggaat cgctagggga atcaacgaac aaggggctct tttgcttgag      900

caggacggtg gaatcaaggc ttacatcgga ggtgagatca gcctcagatc tgct            954


<210>  31
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu 
1               5                   10                  15      


Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu 
            20                  25                  30          


Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu 
        35                  40                  45              


Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg 
    50                  55                  60                  


Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser 
65                  70                  75                  80  


Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln 
                85                  90                  95      


Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr 
            100                 105                 110         


Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu 
        115                 120                 125             


Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly 
    130                 135                 140                 


Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu 
145                 150                 155                 160 


Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg 
                165                 170                 175     


Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro 
            180                 185                 190         


Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His 
        195                 200                 205             


Gln Arg Met Gly Asp 
    210             


<210>  32
<211>  1403
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp 
1               5                   10                  15      


His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val 
            20                  25                  30          


Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys 
        35                  40                  45              


Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu 
    50                  55                  60                  


Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu 
65                  70                  75                  80  


Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln 
                85                  90                  95      


Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg Leu 
            100                 105                 110         


Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly Phe Leu Leu 
        115                 120                 125             


Asn Lys Asp Val Gly Asn Ile Ala Lys Tyr Asp Ile Arg Val Lys Asn 
    130                 135                 140                 


Leu Lys Ser Arg Leu Arg Gly Gly Lys Met Arg Tyr Gln Glu Glu Glu 
145                 150                 155                 160 


Ala Arg Leu Ala Ser Phe Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile 
                165                 170                 175     


Ser Pro Cys Val Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln 
            180                 185                 190         


Asp Thr Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu 
        195                 200                 205             


Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro Lys Cys 
    210                 215                 220                 


Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile 
225                 230                 235                 240 


Gln Ser Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn 
                245                 250                 255     


Ser Trp Val Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp 
            260                 265                 270         


Ser Ile Phe Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp 
        275                 280                 285             


Pro Arg Glu Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu 
    290                 295                 300                 


Phe Tyr Thr Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly 
305                 310                 315                 320 


Cys Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr 
                325                 330                 335     


Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala 
            340                 345                 350         


Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu 
        355                 360                 365             


Glu Thr Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro 
    370                 375                 380                 


Ile Val Pro Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala 
385                 390                 395                 400 


Lys Asn Leu Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe 
                405                 410                 415     


Arg His Met Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His 
            420                 425                 430         


Leu Leu Gly Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro 
        435                 440                 445             


Val Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser 
    450                 455                 460                 


Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu 
465                 470                 475                 480 


Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn 
                485                 490                 495     


Arg Phe Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp 
            500                 505                 510         


Glu Gly Leu Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly 
        515                 520                 525             


Ser Val Thr Glu Met Cys Val Arg Asn Ile Ile Gln Gln Leu Lys Asn 
    530                 535                 540                 


Gln Val Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro 
545                 550                 555                 560 


Gln Val Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys 
                565                 570                 575     


Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr 
            580                 585                 590         


Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val 
        595                 600                 605             


Cys Ile Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys 
    610                 615                 620                 


Phe Met Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys 
625                 630                 635                 640 


Thr Pro Leu Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro 
                645                 650                 655     


Phe Asp Pro Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu 
            660                 665                 670         


Arg Leu Ser Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr 
        675                 680                 685             


Val Ser Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys 
    690                 695                 700                 


Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp 
705                 710                 715                 720 


Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu 
                725                 730                 735     


Arg Pro Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala 
            740                 745                 750         


Gly Met Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln 
        755                 760                 765             


Asp Leu Gly Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr 
    770                 775                 780                 


Val Ser Ala Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser 
785                 790                 795                 800 


Thr Lys Ala Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp 
                805                 810                 815     


Asn Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys 
            820                 825                 830         


His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp 
        835                 840                 845             


Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu 
    850                 855                 860                 


Val Leu Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys 
865                 870                 875                 880 


Ser Pro Phe Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly 
                885                 890                 895     


Ala Leu Asn Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu 
            900                 905                 910         


Leu Arg Ser Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg 
        915                 920                 925             


Ala His Phe Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro 
    930                 935                 940                 


Thr Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp 
945                 950                 955                 960 


Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp 
                965                 970                 975     


Met Gln Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu 
            980                 985                 990         


Ser Pro Lys Gln Tyr Lys Ile Pro  Cys Leu Glu Val Asp  Val Asn Asp 
        995                 1000                 1005             


Ile Asp  Val Val Gly Gln Asp  Met Leu Glu Ile Leu  Met Thr Val 
    1010                 1015                 1020             


Phe Ser  Ala Ser Gln Arg Ile  Glu Leu His Leu Asn  His Ser Arg 
    1025                 1030                 1035             


Gly Phe  Ile Glu Ser Ile Arg  Pro Ala Leu Glu Leu  Ser Lys Ala 
    1040                 1045                 1050             


Ser Val  Thr Lys Cys Ser Ile  Ser Lys Leu Glu Leu  Ser Ala Ala 
    1055                 1060                 1065             


Glu Gln  Glu Leu Leu Leu Thr  Leu Pro Ser Leu Glu  Ser Leu Glu 
    1070                 1075                 1080             


Val Ser  Gly Thr Ile Gln Ser  Gln Asp Gln Ile Phe  Pro Asn Leu 
    1085                 1090                 1095             


Asp Lys  Phe Leu Cys Leu Lys  Glu Leu Ser Val Asp  Leu Glu Gly 
    1100                 1105                 1110             


Asn Ile  Asn Val Phe Ser Val  Ile Pro Glu Glu Phe  Pro Asn Phe 
    1115                 1120                 1125             


His His  Met Glu Lys Leu Leu  Ile Gln Ile Ser Ala  Glu Tyr Asp 
    1130                 1135                 1140             


Pro Ser  Lys Leu Val Lys Leu  Ile Gln Asn Ser Pro  Asn Leu His 
    1145                 1150                 1155             


Val Phe  His Leu Lys Cys Asn  Phe Phe Ser Asp Phe  Gly Ser Leu 
    1160                 1165                 1170             


Met Thr  Met Leu Val Ser Cys  Lys Lys Leu Thr Glu  Ile Lys Phe 
    1175                 1180                 1185             


Ser Asp  Ser Phe Phe Gln Ala  Val Pro Phe Val Ala  Ser Leu Pro 
    1190                 1195                 1200             


Asn Phe  Ile Ser Leu Lys Ile  Leu Asn Leu Glu Gly  Gln Gln Phe 
    1205                 1210                 1215             


Pro Asp  Glu Glu Thr Ser Glu  Lys Phe Ala Tyr Ile  Leu Gly Ser 
    1220                 1225                 1230             


Leu Ser  Asn Leu Glu Glu Leu  Ile Leu Pro Thr Gly  Asp Gly Ile 
    1235                 1240                 1245             


Tyr Arg  Val Ala Lys Leu Ile  Ile Gln Gln Cys Gln  Gln Leu His 
    1250                 1255                 1260             


Cys Leu  Arg Val Leu Ser Phe  Phe Lys Thr Leu Asn  Asp Asp Ser 
    1265                 1270                 1275             


Val Val  Glu Ile Ala Lys Val  Ala Ile Ser Gly Gly  Phe Gln Lys 
    1280                 1285                 1290             


Leu Glu  Asn Leu Lys Leu Ser  Ile Asn His Lys Ile  Thr Glu Glu 
    1295                 1300                 1305             


Gly Tyr  Arg Asn Phe Phe Gln  Ala Leu Asp Asn Met  Pro Asn Leu 
    1310                 1315                 1320             


Gln Glu  Leu Asp Ile Ser Arg  His Phe Thr Glu Cys  Ile Lys Ala 
    1325                 1330                 1335             


Gln Ala  Thr Thr Val Lys Ser  Leu Ser Gln Cys Val  Leu Arg Leu 
    1340                 1345                 1350             


Pro Arg  Leu Ile Arg Leu Asn  Met Leu Ser Trp Leu  Leu Asp Ala 
    1355                 1360                 1365             


Asp Asp  Ile Ala Leu Leu Asn  Val Met Lys Glu Arg  His Pro Gln 
    1370                 1375                 1380             


Ser Lys  Tyr Leu Thr Ile Leu  Gln Lys Trp Ile Leu  Pro Phe Ser 
    1385                 1390                 1395             


Pro Ile  Ile Gln Lys 
    1400             


<210>  33
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  33

Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210>  34
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asn Ile Val Glu Asn Ser Ile Phe Leu Ser Asn Leu Met Lys Ser 
1               5                   10                  15      


Ala Asn Thr Phe Glu Leu Lys Tyr Asp Leu Ser Cys Glu Leu Tyr Arg 
            20                  25                  30          


Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu Arg 
        35                  40                  45              


Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys Val 
    50                  55                  60                  


Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Thr Glu Lys His Lys Lys Leu Tyr Pro Ser Cys Arg Phe Val 
                85                  90                  95      


Gln Ser Leu Asn Ser Val Asn Asn Leu Glu Ala Thr Ser Gln Pro Thr 
            100                 105                 110         


Phe Pro Ser Ser Val Thr Asn Ser Thr His Ser Leu Leu Pro Gly Thr 
        115                 120                 125             


Glu Asn Ser Gly Tyr Phe Arg Gly Ser Tyr Ser Asn Ser Pro Ser Asn 
    130                 135                 140                 


Pro Val Asn Ser Arg Ala Asn Gln Asp Phe Ser Ala Leu Met Arg Ser 
145                 150                 155                 160 


Ser Tyr His Cys Ala Met Asn Asn Glu Asn Ala Arg Leu Leu Thr Phe 
                165                 170                 175     


Gln Thr Trp Pro Leu Thr Phe Leu Ser Pro Thr Asp Leu Ala Lys Ala 
            180                 185                 190         


Gly Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys 
        195                 200                 205             


Gly Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asn Ala Met Ser Glu 
    210                 215                 220                 


His Leu Arg His Phe Pro Lys Cys Pro Phe Ile Glu Asn Gln Leu Gln 
225                 230                 235                 240 


Asp Thr Ser Arg Tyr Thr Val Ser Asn Leu Ser Met Gln Thr His Ala 
                245                 250                 255     


Ala Arg Phe Lys Thr Phe Phe Asn Trp Pro Ser Ser Val Leu Val Asn 
            260                 265                 270         


Pro Glu Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Asn Ser Asp 
        275                 280                 285             


Asp Val Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser 
    290                 295                 300                 


Gly Asp Asp Pro Trp Val Gln His Ala Lys Trp Phe Pro Arg Cys Glu 
305                 310                 315                 320 


Tyr Leu Ile Arg Ile Lys Gly Gln Glu Phe Ile Arg Gln Val Gln Ala 
                325                 330                 335     


Ser Tyr Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Ser Pro 
            340                 345                 350         


Gly Asp Glu Asn Ala Glu Ser Ser Ile Ile His Phe Glu Pro Gly Glu 
        355                 360                 365             


Asp His Ser Glu Asp Ala Ile Met Met Asn Thr Pro Val Ile Asn Ala 
    370                 375                 380                 


Ala Val Glu Met Gly Phe Ser Arg Ser Leu Val Lys Gln Thr Val Gln 
385                 390                 395                 400 


Arg Lys Ile Leu Ala Thr Gly Glu Asn Tyr Arg Leu Val Asn Asp Leu 
                405                 410                 415     


Val Leu Asp Leu Leu Asn Ala Glu Asp Glu Ile Arg Glu Glu Glu Arg 
            420                 425                 430         


Glu Arg Ala Thr Glu Glu Lys Glu Ser Asn Asp Leu Leu Leu Ile Arg 
        435                 440                 445             


Lys Asn Arg Met Ala Leu Phe Gln His Leu Thr Cys Val Ile Pro Ile 
    450                 455                 460                 


Leu Asp Ser Leu Leu Thr Ala Gly Ile Ile Asn Glu Gln Glu His Asp 
465                 470                 475                 480 


Val Ile Lys Gln Lys Thr Gln Thr Ser Leu Gln Ala Arg Glu Leu Ile 
                485                 490                 495     


Asp Thr Ile Leu Val Lys Gly Asn Ile Ala Ala Thr Val Phe Arg Asn 
            500                 505                 510         


Ser Leu Gln Glu Ala Glu Ala Val Leu Tyr Glu His Leu Phe Val Gln 
        515                 520                 525             


Gln Asp Ile Lys Tyr Ile Pro Thr Glu Asp Val Ser Asp Leu Pro Val 
    530                 535                 540                 


Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys 
545                 550                 555                 560 


Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys Gly His Leu Val 
                565                 570                 575     


Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg 
            580                 585                 590         


Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
        595                 600                 


<210>  35
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  36
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  37
<211>  4857
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Val Thr Gly Gly Gly Ala Ala Pro Pro Gly Thr Val Thr Glu Pro 
1               5                   10                  15      


Leu Pro Ser Val Ile Val Leu Ser Ala Gly Arg Lys Met Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ser Gly Pro Gly Cys Ser Ser Ala Ala Gly Ala Gly 
        35                  40                  45              


Ala Ala Gly Val Ser Glu Trp Leu Val Leu Arg Asp Gly Cys Met His 
    50                  55                  60                  


Cys Asp Ala Asp Gly Leu His Ser Leu Ser Tyr His Pro Ala Leu Asn 
65                  70                  75                  80  


Ala Ile Leu Ala Val Thr Ser Arg Gly Thr Ile Lys Val Ile Asp Gly 
                85                  90                  95      


Thr Ser Gly Ala Thr Leu Gln Ala Ser Ala Leu Ser Ala Lys Pro Gly 
            100                 105                 110         


Gly Gln Val Lys Cys Gln Tyr Ile Ser Ala Val Asp Lys Val Ile Phe 
        115                 120                 125             


Val Asp Asp Tyr Ala Val Gly Cys Arg Lys Asp Leu Asn Gly Ile Leu 
    130                 135                 140                 


Leu Leu Asp Thr Ala Leu Gln Thr Pro Val Ser Lys Gln Asp Asp Val 
145                 150                 155                 160 


Val Gln Leu Glu Leu Pro Val Thr Glu Ala Gln Gln Leu Leu Ser Ala 
                165                 170                 175     


Cys Leu Glu Lys Val Asp Ile Ser Ser Thr Glu Gly Tyr Asp Leu Phe 
            180                 185                 190         


Ile Thr Gln Leu Lys Asp Gly Leu Lys Asn Thr Ser His Glu Thr Ala 
        195                 200                 205             


Ala Asn His Lys Val Ala Lys Trp Ala Thr Val Thr Phe His Leu Pro 
    210                 215                 220                 


His His Val Leu Lys Ser Ile Ala Ser Ala Ile Val Asn Glu Leu Lys 
225                 230                 235                 240 


Lys Ile Asn Gln Asn Val Ala Ala Leu Pro Val Ala Ser Ser Val Met 
                245                 250                 255     


Asp Arg Leu Ser Tyr Leu Leu Pro Ser Ala Arg Pro Glu Leu Gly Val 
            260                 265                 270         


Gly Pro Gly Arg Ser Val Asp Arg Ser Leu Met Tyr Ser Glu Ala Asn 
        275                 280                 285             


Arg Arg Glu Thr Phe Thr Ser Trp Pro His Val Gly Tyr Arg Trp Ala 
    290                 295                 300                 


Gln Pro Asp Pro Met Ala Gln Ala Gly Phe Tyr His Gln Pro Ala Ser 
305                 310                 315                 320 


Ser Gly Asp Asp Arg Ala Met Cys Phe Thr Cys Ser Val Cys Leu Val 
                325                 330                 335     


Cys Trp Glu Pro Thr Asp Glu Pro Trp Ser Glu His Glu Arg His Ser 
            340                 345                 350         


Pro Asn Cys Pro Phe Val Lys Gly Glu His Thr Gln Asn Val Pro Leu 
        355                 360                 365             


Ser Val Thr Leu Ala Thr Ser Pro Ala Gln Phe Pro Cys Thr Asp Gly 
    370                 375                 380                 


Thr Asp Arg Ile Ser Cys Phe Gly Ser Gly Ser Cys Pro His Phe Leu 
385                 390                 395                 400 


Ala Ala Ala Thr Lys Arg Gly Lys Ile Cys Ile Trp Asp Val Ser Lys 
                405                 410                 415     


Leu Met Lys Val His Leu Lys Phe Glu Ile Asn Ala Tyr Asp Pro Ala 
            420                 425                 430         


Ile Val Gln Gln Leu Ile Leu Ser Gly Asp Pro Ser Ser Gly Val Asp 
        435                 440                 445             


Ser Arg Arg Pro Thr Leu Ala Trp Leu Glu Asp Ser Ser Ser Cys Ser 
    450                 455                 460                 


Asp Ile Pro Lys Leu Glu Gly Asp Ser Asp Asp Leu Leu Glu Asp Ser 
465                 470                 475                 480 


Asp Ser Glu Glu His Ser Arg Ser Asp Ser Val Thr Gly His Thr Ser 
                485                 490                 495     


Gln Lys Glu Ala Met Glu Val Ser Leu Asp Ile Thr Ala Leu Ser Ile 
            500                 505                 510         


Leu Gln Gln Pro Glu Lys Leu Gln Trp Glu Ile Val Ala Asn Val Leu 
        515                 520                 525             


Glu Asp Thr Val Lys Asp Leu Glu Glu Leu Gly Ala Asn Pro Cys Leu 
    530                 535                 540                 


Thr Asn Ser Lys Ser Glu Lys Thr Lys Glu Lys His Gln Glu Gln His 
545                 550                 555                 560 


Asn Ile Pro Phe Pro Cys Leu Leu Ala Gly Gly Leu Leu Thr Tyr Lys 
                565                 570                 575     


Ser Pro Ala Thr Ser Pro Ile Ser Ser Asn Ser His Arg Ser Leu Asp 
            580                 585                 590         


Gly Leu Ser Arg Thr Gln Gly Glu Ser Ile Ser Glu Gln Gly Ser Thr 
        595                 600                 605             


Asp Asn Glu Ser Cys Thr Asn Ser Glu Leu Asn Ser Pro Leu Val Arg 
    610                 615                 620                 


Arg Thr Leu Pro Val Leu Leu Leu Tyr Ser Ile Lys Glu Ser Asp Glu 
625                 630                 635                 640 


Lys Ala Gly Lys Ile Phe Ser Gln Met Asn Asn Ile Met Ser Lys Ser 
                645                 650                 655     


Leu His Asp Asp Gly Phe Thr Val Pro Gln Ile Ile Glu Met Glu Leu 
            660                 665                 670         


Asp Ser Gln Glu Gln Leu Leu Leu Gln Asp Pro Pro Val Thr Tyr Ile 
        675                 680                 685             


Gln Gln Phe Ala Asp Ala Ala Ala Asn Leu Thr Ser Pro Asp Ser Glu 
    690                 695                 700                 


Lys Trp Asn Ser Val Phe Pro Lys Pro Gly Thr Leu Val Gln Cys Leu 
705                 710                 715                 720 


Arg Leu Pro Lys Phe Ala Glu Glu Glu Asn Leu Cys Ile Asp Ser Ile 
                725                 730                 735     


Thr Pro Cys Ala Asp Gly Ile His Leu Leu Val Gly Leu Arg Thr Cys 
            740                 745                 750         


Pro Val Glu Ser Leu Ser Ala Ile Asn Gln Val Glu Ala Leu Asn Asn 
        755                 760                 765             


Leu Asn Lys Leu Asn Ser Ala Leu Cys Asn Arg Arg Lys Gly Glu Leu 
    770                 775                 780                 


Glu Ser Asn Leu Ala Val Val Asn Gly Ala Asn Ile Ser Val Ile Gln 
785                 790                 795                 800 


His Glu Ser Pro Ala Asp Val Gln Thr Pro Leu Ile Ile Gln Pro Glu 
                805                 810                 815     


Gln Arg Asn Val Ser Gly Gly Tyr Leu Val Leu Tyr Lys Met Asn Tyr 
            820                 825                 830         


Ala Thr Arg Ile Val Thr Leu Glu Glu Glu Pro Ile Lys Ile Gln His 
        835                 840                 845             


Ile Lys Asp Pro Gln Asp Thr Ile Thr Ser Leu Ile Leu Leu Pro Pro 
    850                 855                 860                 


Asp Ile Leu Asp Asn Arg Glu Asp Asp Cys Glu Glu Pro Ile Glu Asp 
865                 870                 875                 880 


Met Gln Leu Thr Ser Lys Asn Gly Phe Glu Arg Glu Lys Thr Ser Asp 
                885                 890                 895     


Ile Ser Thr Leu Gly His Leu Val Ile Thr Thr Gln Gly Gly Tyr Val 
            900                 905                 910         


Lys Ile Leu Asp Leu Ser Asn Phe Glu Ile Leu Ala Lys Val Glu Pro 
        915                 920                 925             


Pro Lys Lys Glu Gly Thr Glu Glu Gln Asp Thr Phe Val Ser Val Ile 
    930                 935                 940                 


Tyr Cys Ser Gly Thr Asp Arg Leu Cys Ala Cys Thr Lys Gly Gly Glu 
945                 950                 955                 960 


Leu His Phe Leu Gln Ile Gly Gly Thr Cys Asp Asp Ile Asp Glu Ala 
                965                 970                 975     


Asp Ile Leu Val Asp Gly Ser Leu Ser Lys Gly Ile Glu Pro Ser Ser 
            980                 985                 990         


Glu Gly Ser Lys Pro Leu Ser Asn  Pro Ser Ser Pro Gly  Ile Ser Gly 
        995                 1000                 1005             


Val Asp  Leu Leu Val Asp Gln  Pro Phe Thr Leu Glu  Ile Leu Thr 
    1010                 1015                 1020             


Ser Leu  Val Glu Leu Thr Arg  Phe Glu Thr Leu Thr  Pro Arg Phe 
    1025                 1030                 1035             


Ser Ala  Thr Val Pro Pro Cys  Trp Val Glu Val Gln  Gln Glu Gln 
    1040                 1045                 1050             


Gln Gln  Arg Arg His Pro Gln  His Leu His Gln Gln  His His Gly 
    1055                 1060                 1065             


Asp Ala  Ala Gln His Thr Arg  Thr Trp Lys Leu Gln  Thr Asp Ser 
    1070                 1075                 1080             


Asn Ser  Trp Asp Glu His Val  Phe Glu Leu Val Leu  Pro Lys Ala 
    1085                 1090                 1095             


Cys Met  Val Gly His Val Asp  Phe Lys Phe Val Leu  Asn Ser Asn 
    1100                 1105                 1110             


Ile Thr  Asn Ile Pro Gln Ile  Gln Val Thr Leu Leu  Lys Asn Lys 
    1115                 1120                 1125             


Ala Pro  Gly Leu Gly Lys Val  Asn Ala Leu Asn Ile  Glu Val Glu 
    1130                 1135                 1140             


Gln Asn  Gly Lys Pro Ser Leu  Val Asp Leu Asn Glu  Glu Met Gln 
    1145                 1150                 1155             


His Met  Asp Val Glu Glu Ser  Gln Cys Leu Arg Leu  Cys Pro Phe 
    1160                 1165                 1170             


Leu Glu  Asp His Lys Glu Asp  Ile Leu Cys Gly Pro  Val Trp Leu 
    1175                 1180                 1185             


Ala Ser  Gly Leu Asp Leu Ser  Gly His Ala Gly Met  Leu Thr Leu 
    1190                 1195                 1200             


Thr Ser  Pro Lys Leu Val Lys  Gly Met Ala Gly Gly  Lys Tyr Arg 
    1205                 1210                 1215             


Ser Phe  Leu Ile His Val Lys  Ala Val Asn Glu Arg  Gly Thr Glu 
    1220                 1225                 1230             


Glu Ile  Cys Asn Gly Gly Met  Arg Pro Val Val Arg  Leu Pro Ser 
    1235                 1240                 1245             


Leu Lys  His Gln Ser Asn Lys  Gly Tyr Ser Leu Ala  Ser Leu Leu 
    1250                 1255                 1260             


Ala Lys  Val Ala Ala Gly Lys  Glu Lys Ser Ser Asn  Val Lys Asn 
    1265                 1270                 1275             


Glu Asn  Thr Ser Gly Thr Arg  Lys Ser Glu Asn Leu  Arg Gly Cys 
    1280                 1285                 1290             


Asp Leu  Leu Gln Glu Val Ser  Val Thr Ile Arg Arg  Phe Lys Lys 
    1295                 1300                 1305             


Thr Ser  Ile Ser Lys Glu Arg  Val Gln Arg Cys Ala  Met Leu Gln 
    1310                 1315                 1320             


Phe Ser  Glu Phe His Glu Lys  Leu Val Asn Thr Leu  Cys Arg Lys 
    1325                 1330                 1335             


Thr Asp  Asp Gly Gln Ile Thr  Glu His Ala Gln Ser  Leu Val Leu 
    1340                 1345                 1350             


Asp Thr  Leu Cys Trp Leu Ala  Gly Val His Ser Asn  Gly Pro Gly 
    1355                 1360                 1365             


Ser Ser  Lys Glu Gly Asn Glu  Asn Leu Leu Ser Lys  Thr Arg Lys 
    1370                 1375                 1380             


Phe Leu  Ser Asp Ile Val Arg  Val Cys Phe Phe Glu  Ala Gly Arg 
    1385                 1390                 1395             


Ser Ile  Ala His Lys Cys Ala  Arg Phe Leu Ala Leu  Cys Ile Ser 
    1400                 1405                 1410             


Asn Gly  Lys Cys Asp Pro Cys  Gln Pro Ala Phe Gly  Pro Val Leu 
    1415                 1420                 1425             


Leu Lys  Ala Leu Leu Asp Asn  Met Ser Phe Leu Pro  Ala Ala Thr 
    1430                 1435                 1440             


Thr Gly  Gly Ser Val Tyr Trp  Tyr Phe Val Leu Leu  Asn Tyr Val 
    1445                 1450                 1455             


Lys Asp  Glu Asp Leu Ala Gly  Cys Ser Thr Ala Cys  Ala Ser Leu 
    1460                 1465                 1470             


Leu Thr  Ala Val Ser Arg Gln  Leu Gln Asp Arg Leu  Thr Pro Met 
    1475                 1480                 1485             


Glu Ala  Leu Leu Gln Thr Arg  Tyr Gly Leu Tyr Ser  Ser Pro Phe 
    1490                 1495                 1500             


Asp Pro  Val Leu Phe Asp Leu  Glu Met Ser Gly Ser  Ser Cys Lys 
    1505                 1510                 1515             


Asn Val  Tyr Asn Ser Ser Ile  Gly Val Gln Ser Asp  Glu Ile Asp 
    1520                 1525                 1530             


Leu Ser  Asp Val Leu Ser Gly  Asn Gly Lys Val Ser  Ser Cys Thr 
    1535                 1540                 1545             


Ala Ala  Glu Gly Ser Phe Thr  Ser Leu Thr Gly Leu  Leu Glu Val 
    1550                 1555                 1560             


Glu Pro  Leu His Phe Thr Cys  Val Ser Thr Ser Asp  Gly Thr Arg 
    1565                 1570                 1575             


Ile Glu  Arg Asp Asp Ala Met  Ser Ser Phe Gly Val  Thr Pro Ala 
    1580                 1585                 1590             


Val Gly  Gly Leu Ser Ser Gly  Thr Val Gly Glu Ala  Ser Thr Ala 
    1595                 1600                 1605             


Leu Ser  Ser Ala Ala Gln Val  Ala Leu Gln Ser Leu  Ser His Ala 
    1610                 1615                 1620             


Met Ala  Ser Ala Glu Gln Gln  Leu Gln Val Leu Gln  Glu Lys Gln 
    1625                 1630                 1635             


Gln Gln  Leu Leu Lys Leu Gln  Gln Gln Lys Ala Lys  Leu Glu Ala 
    1640                 1645                 1650             


Lys Leu  His Gln Thr Thr Ala  Ala Ala Ala Ala Ala  Ala Ser Ala 
    1655                 1660                 1665             


Val Gly  Pro Val His Asn Ser  Val Pro Ser Asn Pro  Val Ala Ala 
    1670                 1675                 1680             


Pro Gly  Phe Phe Ile His Pro  Ser Asp Val Ile Pro  Pro Thr Pro 
    1685                 1690                 1695             


Lys Thr  Thr Pro Leu Phe Met  Thr Pro Pro Leu Thr  Pro Pro Asn 
    1700                 1705                 1710             


Glu Ala  Val Ser Val Val Ile  Asn Ala Glu Leu Ala  Gln Leu Phe 
    1715                 1720                 1725             


Pro Gly  Ser Val Ile Asp Pro  Pro Ala Val Asn Leu  Ala Ala His 
    1730                 1735                 1740             


Asn Lys  Asn Ser Asn Lys Ser  Arg Met Asn Pro Leu  Gly Ser Gly 
    1745                 1750                 1755             


Leu Ala  Leu Ala Ile Ser His  Ala Ser His Phe Leu  Gln Pro Pro 
    1760                 1765                 1770             


Pro His  Gln Ser Ile Ile Ile  Glu Arg Met His Ser  Gly Ala Arg 
    1775                 1780                 1785             


Arg Phe  Val Thr Leu Asp Phe  Gly Arg Pro Ile Leu  Leu Thr Asp 
    1790                 1795                 1800             


Val Leu  Ile Pro Thr Cys Gly  Asp Leu Ala Ser Leu  Ser Ile Asp 
    1805                 1810                 1815             


Ile Trp  Thr Leu Gly Glu Glu  Val Asp Gly Arg Arg  Leu Val Val 
    1820                 1825                 1830             


Ala Thr  Asp Ile Ser Thr His  Ser Leu Ile Leu His  Asp Leu Ile 
    1835                 1840                 1845             


Pro Pro  Pro Val Cys Arg Phe  Met Lys Ile Thr Val  Ile Gly Arg 
    1850                 1855                 1860             


Tyr Gly  Ser Thr Asn Ala Arg  Ala Lys Ile Pro Leu  Gly Phe Tyr 
    1865                 1870                 1875             


Tyr Gly  His Thr Tyr Ile Leu  Pro Trp Glu Ser Glu  Leu Lys Leu 
    1880                 1885                 1890             


Met His  Asp Pro Leu Lys Gly  Glu Gly Glu Ser Ala  Asn Gln Pro 
    1895                 1900                 1905             


Glu Ile  Asp Gln His Leu Ala  Met Met Val Ala Leu  Gln Glu Asp 
    1910                 1915                 1920             


Ile Gln  Cys Arg Tyr Asn Leu  Ala Cys His Arg Leu  Glu Thr Leu 
    1925                 1930                 1935             


Leu Gln  Ser Ile Asp Leu Pro  Pro Leu Asn Ser Ala  Asn Asn Ala 
    1940                 1945                 1950             


Gln Tyr  Phe Leu Arg Lys Pro  Asp Lys Ala Val Glu  Glu Asp Ser 
    1955                 1960                 1965             


Arg Val  Phe Ser Ala Tyr Gln  Asp Cys Ile Gln Leu  Gln Leu Gln 
    1970                 1975                 1980             


Leu Asn  Leu Ala His Asn Ala  Val Gln Arg Leu Lys  Val Ala Leu 
    1985                 1990                 1995             


Gly Ala  Ser Arg Lys Met Leu  Ser Glu Thr Ser Asn  Pro Glu Asp 
    2000                 2005                 2010             


Leu Ile  Gln Thr Ser Ser Thr  Glu Gln Leu Arg Thr  Ile Ile Arg 
    2015                 2020                 2025             


Tyr Leu  Leu Asp Thr Leu Leu  Ser Leu Leu His Ala  Ser Asn Gly 
    2030                 2035                 2040             


His Ser  Val Pro Ala Val Leu  Gln Ser Thr Phe His  Ala Gln Ala 
    2045                 2050                 2055             


Cys Glu  Glu Leu Phe Lys His  Leu Cys Ile Ser Gly  Thr Pro Lys 
    2060                 2065                 2070             


Ile Arg  Leu His Thr Gly Leu  Leu Leu Val Gln Leu  Cys Gly Gly 
    2075                 2080                 2085             


Glu Arg  Trp Trp Gly Gln Phe  Leu Ser Asn Val Leu  Gln Glu Leu 
    2090                 2095                 2100             


Tyr Asn  Ser Glu Gln Leu Leu  Ile Phe Pro Gln Asp  Arg Val Phe 
    2105                 2110                 2115             


Met Leu  Leu Ser Cys Ile Gly  Gln Arg Ser Leu Ser  Asn Ser Gly 
    2120                 2125                 2130             


Val Leu  Glu Ser Leu Leu Asn  Leu Leu Asp Asn Leu  Leu Ser Pro 
    2135                 2140                 2145             


Leu Gln  Pro Gln Leu Pro Met  His Arg Arg Thr Glu  Gly Val Leu 
    2150                 2155                 2160             


Asp Ile  Pro Met Ile Ser Trp  Val Val Met Leu Val  Ser Arg Leu 
    2165                 2170                 2175             


Leu Asp  Tyr Val Ala Thr Val  Glu Asp Glu Ala Ala  Ala Ala Lys 
    2180                 2185                 2190             


Lys Pro  Leu Asn Gly Asn Gln  Trp Ser Phe Ile Asn  Asn Asn Leu 
    2195                 2200                 2205             


His Thr  Gln Ser Leu Asn Arg  Ser Ser Lys Gly Ser  Ser Ser Leu 
    2210                 2215                 2220             


Asp Arg  Leu Tyr Ser Arg Lys  Ile Arg Lys Gln Leu  Val His His 
    2225                 2230                 2235             


Lys Gln  Gln Leu Asn Leu Leu  Lys Ala Lys Gln Lys  Ala Leu Val 
    2240                 2245                 2250             


Glu Gln  Met Glu Lys Glu Lys  Ile Gln Ser Asn Lys  Gly Ser Ser 
    2255                 2260                 2265             


Tyr Lys  Leu Leu Val Glu Gln  Ala Lys Leu Lys Gln  Ala Thr Ser 
    2270                 2275                 2280             


Lys His  Phe Lys Asp Leu Ile  Arg Leu Arg Arg Thr  Ala Glu Trp 
    2285                 2290                 2295             


Ser Arg  Ser Asn Leu Asp Thr  Glu Val Thr Thr Ala  Lys Glu Ser 
    2300                 2305                 2310             


Pro Glu  Ile Glu Pro Leu Pro  Phe Thr Leu Ala His  Glu Arg Cys 
    2315                 2320                 2325             


Ile Ser  Val Val Gln Lys Leu  Val Leu Phe Leu Leu  Ser Met Asp 
    2330                 2335                 2340             


Phe Thr  Cys His Ala Asp Leu  Leu Leu Phe Val Cys  Lys Val Leu 
    2345                 2350                 2355             


Ala Arg  Ile Ala Asn Ala Thr  Arg Pro Thr Ile His  Leu Cys Glu 
    2360                 2365                 2370             


Ile Val  Asn Glu Pro Gln Leu  Glu Arg Leu Leu Leu  Leu Leu Val 
    2375                 2380                 2385             


Gly Thr  Asp Phe Asn Arg Gly  Asp Ile Ser Trp Gly  Gly Ala Trp 
    2390                 2395                 2400             


Ala Gln  Tyr Ser Leu Thr Cys  Met Leu Gln Asp Ile  Leu Ala Gly 
    2405                 2410                 2415             


Glu Leu  Leu Ala Pro Val Ala  Ala Glu Ala Met Glu  Glu Gly Thr 
    2420                 2425                 2430             


Val Gly  Asp Asp Val Gly Ala  Thr Ala Gly Asp Ser  Asp Asp Ser 
    2435                 2440                 2445             


Leu Gln  Gln Ser Ser Val Gln  Leu Leu Glu Thr Ile  Asp Glu Pro 
    2450                 2455                 2460             


Leu Thr  His Asp Ile Thr Gly  Ala Pro Pro Leu Ser  Ser Leu Glu 
    2465                 2470                 2475             


Lys Asp  Lys Glu Ile Asp Leu  Glu Leu Leu Gln Asp  Leu Met Glu 
    2480                 2485                 2490             


Val Asp  Ile Asp Pro Leu Asp  Ile Asp Leu Glu Lys  Asp Pro Leu 
    2495                 2500                 2505             


Ala Ala  Lys Val Phe Lys Pro  Ile Ser Ser Thr Trp  Tyr Asp Tyr 
    2510                 2515                 2520             


Trp Gly  Ala Asp Tyr Gly Thr  Tyr Asn Tyr Asn Pro  Tyr Ile Gly 
    2525                 2530                 2535             


Gly Leu  Gly Ile Pro Val Ala  Lys Pro Pro Ala Asn  Thr Glu Lys 
    2540                 2545                 2550             


Asn Gly  Ser Gln Thr Val Ser  Val Ser Val Ser Gln  Ala Leu Asp 
    2555                 2560                 2565             


Ala Arg  Leu Glu Val Gly Leu  Glu Gln Gln Ala Glu  Leu Met Leu 
    2570                 2575                 2580             


Lys Met  Met Ser Thr Leu Glu  Ala Asp Ser Ile Leu  Gln Ala Leu 
    2585                 2590                 2595             


Thr Asn  Thr Ser Pro Thr Leu  Ser Gln Ser Pro Thr  Gly Thr Asp 
    2600                 2605                 2610             


Asp Ser  Leu Leu Gly Gly Leu  Gln Ala Ala Asn Gln  Thr Ser Gln 
    2615                 2620                 2625             


Leu Ile  Ile Gln Leu Ser Ser  Val Pro Met Leu Asn  Val Cys Phe 
    2630                 2635                 2640             


Asn Lys  Leu Phe Ser Met Leu  Gln Val His His Val  Gln Leu Glu 
    2645                 2650                 2655             


Ser Leu  Leu Gln Leu Trp Leu  Thr Leu Ser Leu Asn  Ser Ser Ser 
    2660                 2665                 2670             


Thr Gly  Asn Lys Glu Asn Gly  Ala Asp Ile Phe Leu  Tyr Asn Ala 
    2675                 2680                 2685             


Asn Arg  Ile Pro Val Ile Ser  Leu Asn Gln Ala Ser  Ile Thr Ser 
    2690                 2695                 2700             


Phe Leu  Thr Val Leu Ala Trp  Tyr Pro Asn Thr Leu  Leu Arg Thr 
    2705                 2710                 2715             


Trp Cys  Leu Val Leu His Ser  Leu Thr Leu Met Thr  Asn Met Gln 
    2720                 2725                 2730             


Leu Asn  Ser Gly Ser Ser Ser  Ala Ile Gly Thr Gln  Glu Ser Thr 
    2735                 2740                 2745             


Ala His  Leu Leu Val Ser Asp  Pro Asn Leu Ile His  Val Leu Val 
    2750                 2755                 2760             


Lys Phe  Leu Ser Gly Thr Ser  Pro His Gly Thr Asn  Gln His Ser 
    2765                 2770                 2775             


Pro Gln  Val Gly Pro Thr Ala  Thr Gln Ala Met Gln  Glu Phe Leu 
    2780                 2785                 2790             


Thr Arg  Leu Gln Val His Leu  Ser Ser Thr Cys Pro  Gln Ile Phe 
    2795                 2800                 2805             


Ser Glu  Phe Leu Leu Lys Leu  Ile His Ile Leu Ser  Thr Glu Arg 
    2810                 2815                 2820             


Gly Ala  Phe Gln Thr Gly Gln  Gly Pro Leu Asp Ala  Gln Val Lys 
    2825                 2830                 2835             


Leu Leu  Glu Phe Thr Leu Glu  Gln Asn Phe Glu Val  Val Ser Val 
    2840                 2845                 2850             


Ser Thr  Ile Ser Ala Val Ile  Glu Ser Val Thr Phe  Leu Val His 
    2855                 2860                 2865             


His Tyr  Ile Thr Cys Ser Asp  Lys Val Met Ser Arg  Ser Gly Ser 
    2870                 2875                 2880             


Asp Ser  Ser Val Gly Ala Arg  Ala Cys Phe Gly Gly  Leu Phe Ala 
    2885                 2890                 2895             


Asn Leu  Ile Arg Pro Gly Asp  Ala Lys Ala Val Cys  Gly Glu Met 
    2900                 2905                 2910             


Thr Arg  Asp Gln Leu Met Phe  Asp Leu Leu Lys Leu  Val Asn Ile 
    2915                 2920                 2925             


Leu Val  Gln Leu Pro Leu Ser  Gly Asn Arg Glu Tyr  Ser Ala Arg 
    2930                 2935                 2940             


Val Ser  Val Thr Thr Asn Thr  Thr Asp Ser Val Ser  Asp Glu Glu 
    2945                 2950                 2955             


Lys Val  Ser Gly Gly Lys Asp  Gly Asn Gly Ser Ser  Thr Ser Val 
    2960                 2965                 2970             


Gln Gly  Ser Pro Ala Tyr Val  Ala Asp Leu Val Leu  Ala Asn Gln 
    2975                 2980                 2985             


Gln Ile  Met Ser Gln Ile Leu  Ser Ala Leu Gly Leu  Cys Asn Ser 
    2990                 2995                 3000             


Ser Ala  Met Ala Met Ile Ile  Gly Ala Ser Gly Leu  His Leu Thr 
    3005                 3010                 3015             


Lys His  Glu Asn Phe His Gly  Gly Leu Asp Ala Ile  Ser Val Gly 
    3020                 3025                 3030             


Asp Gly  Leu Phe Thr Ile Leu  Thr Thr Leu Ser Lys  Lys Ala Ser 
    3035                 3040                 3045             


Thr Val  His Met Met Leu Gln  Pro Ile Leu Thr Tyr  Met Ala Cys 
    3050                 3055                 3060             


Gly Tyr  Met Gly Arg Gln Gly  Ser Leu Ala Thr Cys  Gln Leu Ser 
    3065                 3070                 3075             


Glu Pro  Leu Leu Trp Phe Ile  Leu Arg Val Leu Asp  Thr Ser Asp 
    3080                 3085                 3090             


Ala Leu  Lys Ala Phe His Asp  Met Gly Gly Val Gln  Leu Ile Cys 
    3095                 3100                 3105             


Asn Asn  Met Val Thr Ser Thr  Arg Ala Ile Val Asn  Thr Ala Arg 
    3110                 3115                 3120             


Ser Met  Val Ser Thr Ile Met  Lys Phe Leu Asp Ser  Gly Pro Asn 
    3125                 3130                 3135             


Lys Ala  Val Asp Ser Thr Leu  Lys Thr Arg Ile Leu  Ala Ser Glu 
    3140                 3145                 3150             


Pro Asp  Asn Ala Glu Gly Ile  His Asn Phe Ala Pro  Leu Gly Thr 
    3155                 3160                 3165             


Ile Thr  Ser Ser Ser Pro Thr  Ala Gln Pro Ala Glu  Val Leu Leu 
    3170                 3175                 3180             


Gln Ala  Thr Pro Pro His Arg  Arg Ala Arg Ser Ala  Ala Trp Ser 
    3185                 3190                 3195             


Tyr Ile  Phe Leu Pro Glu Glu  Ala Trp Cys Asp Leu  Thr Ile His 
    3200                 3205                 3210             


Leu Pro  Ala Ala Val Leu Leu  Lys Glu Ile His Ile  Gln Pro His 
    3215                 3220                 3225             


Leu Ala  Ser Leu Ala Thr Cys  Pro Ser Ser Val Ser  Val Glu Val 
    3230                 3235                 3240             


Ser Ala  Asp Gly Val Asn Met  Leu Pro Leu Ser Thr  Pro Val Val 
    3245                 3250                 3255             


Thr Ser  Gly Leu Thr Tyr Ile  Lys Ile Gln Leu Val  Lys Ala Glu 
    3260                 3265                 3270             


Val Ala  Ser Ala Val Cys Leu  Arg Leu His Arg Pro  Arg Asp Ala 
    3275                 3280                 3285             


Ser Thr  Leu Gly Leu Ser Gln  Ile Lys Leu Leu Gly  Leu Thr Ala 
    3290                 3295                 3300             


Phe Gly  Thr Thr Ser Ser Ala  Thr Val Asn Asn Pro  Phe Leu Pro 
    3305                 3310                 3315             


Ser Glu  Asp Gln Val Ser Lys  Thr Ser Ile Gly Trp  Leu Arg Leu 
    3320                 3325                 3330             


Leu His  His Cys Leu Thr His  Ile Ser Asp Leu Glu  Gly Met Met 
    3335                 3340                 3345             


Ala Ser  Ala Ala Ala Pro Thr  Ala Asn Leu Leu Gln  Thr Cys Ala 
    3350                 3355                 3360             


Ala Leu  Leu Met Ser Pro Tyr  Cys Gly Met His Ser  Pro Asn Ile 
    3365                 3370                 3375             


Glu Val  Val Leu Val Lys Ile  Gly Leu Gln Ser Thr  Arg Ile Gly 
    3380                 3385                 3390             


Leu Lys  Leu Ile Asp Ile Leu  Leu Arg Asn Cys Ala  Ala Ser Gly 
    3395                 3400                 3405             


Ser Asp  Pro Thr Asp Leu Asn  Ser Pro Leu Leu Phe  Gly Arg Leu 
    3410                 3415                 3420             


Asn Gly  Leu Ser Ser Asp Ser  Thr Ile Asp Ile Leu  Tyr Gln Leu 
    3425                 3430                 3435             


Gly Thr  Thr Gln Asp Pro Gly  Thr Lys Asp Arg Ile  Gln Ala Leu 
    3440                 3445                 3450             


Leu Lys  Trp Val Ser Asp Ser  Ala Arg Val Ala Ala  Met Lys Arg 
    3455                 3460                 3465             


Ser Gly  Arg Met Asn Tyr Met  Cys Pro Asn Ser Ser  Thr Val Glu 
    3470                 3475                 3480             


Tyr Gly  Leu Leu Met Pro Ser  Pro Ser His Leu His  Cys Val Ala 
    3485                 3490                 3495             


Ala Ile  Leu Trp His Ser Tyr  Glu Leu Leu Val Glu  Tyr Asp Leu 
    3500                 3505                 3510             


Pro Ala  Leu Leu Asp Gln Glu  Leu Phe Glu Leu Leu  Phe Asn Trp 
    3515                 3520                 3525             


Ser Met  Ser Leu Pro Cys Asn  Met Val Leu Lys Lys  Ala Val Asp 
    3530                 3535                 3540             


Ser Leu  Leu Cys Ser Met Cys  His Val His Pro Asn  Tyr Phe Ser 
    3545                 3550                 3555             


Leu Leu  Met Gly Trp Met Gly  Ile Thr Pro Pro Pro  Val Gln Cys 
    3560                 3565                 3570             


His His  Arg Leu Ser Met Thr  Asp Asp Ser Lys Lys  Gln Asp Leu 
    3575                 3580                 3585             


Ser Ser  Ser Leu Thr Asp Asp  Ser Lys Asn Ala Gln  Ala Pro Leu 
    3590                 3595                 3600             


Ala Leu  Thr Glu Ser His Leu  Ala Thr Leu Ala Ser  Ser Ser Gln 
    3605                 3610                 3615             


Ser Pro  Glu Ala Ile Lys Gln  Leu Leu Asp Ser Gly  Leu Pro Ser 
    3620                 3625                 3630             


Leu Leu  Val Arg Ser Leu Ala  Ser Phe Cys Phe Ser  His Ile Ser 
    3635                 3640                 3645             


Ser Ser  Glu Ser Ile Ala Gln  Ser Ile Asp Ile Ser  Gln Asp Lys 
    3650                 3655                 3660             


Leu Arg  Arg His His Val Pro  Gln Gln Cys Asn Lys  Met Pro Ile 
    3665                 3670                 3675             


Thr Ala  Asp Leu Val Ala Pro  Ile Leu Arg Phe Leu  Thr Glu Val 
    3680                 3685                 3690             


Gly Asn  Ser His Ile Met Lys  Asp Trp Leu Gly Gly  Ser Glu Val 
    3695                 3700                 3705             


Asn Pro  Leu Trp Thr Ala Leu  Leu Phe Leu Leu Cys  His Ser Gly 
    3710                 3715                 3720             


Ser Thr  Ser Gly Ser His Asn  Leu Gly Ala Gln Gln  Thr Ser Ala 
    3725                 3730                 3735             


Arg Ser  Ala Ser Leu Ser Ser  Ala Ala Thr Thr Gly  Leu Thr Thr 
    3740                 3745                 3750             


Gln Gln  Arg Thr Ala Ile Glu  Asn Ala Thr Val Ala  Phe Phe Leu 
    3755                 3760                 3765             


Gln Cys  Ile Ser Cys His Pro  Asn Asn Gln Lys Leu  Met Ala Gln 
    3770                 3775                 3780             


Val Leu  Cys Glu Leu Phe Gln  Thr Ser Pro Gln Arg  Gly Asn Leu 
    3785                 3790                 3795             


Pro Thr  Ser Gly Asn Ile Ser  Gly Phe Ile Arg Arg  Leu Phe Leu 
    3800                 3805                 3810             


Gln Leu  Met Leu Glu Asp Glu  Lys Val Thr Met Phe  Leu Gln Ser 
    3815                 3820                 3825             


Pro Cys  Pro Leu Tyr Lys Gly  Arg Ile Asn Ala Thr  Ser His Val 
    3830                 3835                 3840             


Ile Gln  His Pro Met Tyr Gly  Ala Gly His Lys Phe  Arg Thr Leu 
    3845                 3850                 3855             


His Leu  Pro Val Ser Thr Thr  Leu Ser Asp Val Leu  Asp Arg Val 
    3860                 3865                 3870             


Ser Asp  Thr Pro Ser Ile Thr  Ala Lys Leu Ile Ser  Glu Gln Lys 
    3875                 3880                 3885             


Asp Asp  Lys Glu Lys Lys Asn  His Glu Glu Lys Glu  Lys Val Lys 
    3890                 3895                 3900             


Ala Glu  Asn Gly Phe Gln Asp  Asn Tyr Ser Val Val  Val Ala Ser 
    3905                 3910                 3915             


Gly Leu  Lys Ser Gln Ser Lys  Arg Ala Val Ser Ala  Thr Pro Pro 
    3920                 3925                 3930             


Arg Pro  Pro Ser Arg Arg Gly  Arg Thr Ile Pro Asp  Lys Ile Gly 
    3935                 3940                 3945             


Ser Thr  Ser Gly Ala Glu Ala  Ala Asn Lys Ile Ile  Thr Val Pro 
    3950                 3955                 3960             


Val Phe  His Leu Phe His Lys  Leu Leu Ala Gly Gln  Pro Leu Pro 
    3965                 3970                 3975             


Ala Glu  Met Thr Leu Ala Gln  Leu Leu Thr Leu Leu  Tyr Asp Arg 
    3980                 3985                 3990             


Lys Leu  Pro Gln Gly Tyr Arg  Ser Ile Asp Leu Thr  Val Lys Leu 
    3995                 4000                 4005             


Gly Ser  Arg Val Ile Thr Asp  Pro Ser Leu Ser Lys  Thr Asp Ser 
    4010                 4015                 4020             


Tyr Lys  Arg Leu His Pro Glu  Lys Asp His Gly Asp  Leu Leu Ala 
    4025                 4030                 4035             


Ser Cys  Pro Glu Asp Glu Ala  Leu Thr Pro Gly Asp  Glu Cys Met 
    4040                 4045                 4050             


Asp Gly  Ile Leu Asp Glu Ser  Leu Leu Glu Thr Cys  Pro Ile Gln 
    4055                 4060                 4065             


Ser Pro  Leu Gln Val Phe Ala  Gly Met Gly Gly Leu  Ala Leu Ile 
    4070                 4075                 4080             


Ala Glu  Arg Leu Pro Met Leu  Tyr Pro Glu Val Ile  Gln Gln Val 
    4085                 4090                 4095             


Ser Ala  Pro Val Val Thr Ser  Thr Thr Gln Glu Lys  Pro Lys Asp 
    4100                 4105                 4110             


Ser Asp  Gln Phe Glu Trp Val  Thr Ile Glu Gln Ser  Gly Glu Leu 
    4115                 4120                 4125             


Val Tyr  Glu Ala Pro Glu Thr  Val Ala Ala Glu Pro  Pro Pro Ile 
    4130                 4135                 4140             


Lys Ser  Ala Val Gln Thr Met  Ser Pro Ile Pro Ala  His Ser Leu 
    4145                 4150                 4155             


Ala Ala  Phe Gly Leu Phe Leu  Arg Leu Pro Gly Tyr  Ala Glu Val 
    4160                 4165                 4170             


Leu Leu  Lys Glu Arg Lys His  Ala Gln Cys Leu Leu  Arg Leu Val 
    4175                 4180                 4185             


Leu Gly  Val Thr Asp Asp Gly  Glu Gly Ser His Ile  Leu Gln Ser 
    4190                 4195                 4200             


Pro Ser  Ala Asn Val Leu Pro  Thr Leu Pro Phe His  Val Leu Arg 
    4205                 4210                 4215             


Ser Leu  Phe Ser Thr Thr Pro  Leu Thr Thr Asp Asp  Gly Val Leu 
    4220                 4225                 4230             


Leu Arg  Arg Met Ala Leu Glu  Ile Gly Ala Leu His  Leu Ile Leu 
    4235                 4240                 4245             


Val Cys  Leu Ser Ala Leu Ser  His His Ser Pro Arg  Val Pro Asn 
    4250                 4255                 4260             


Ser Ser  Val Asn Gln Thr Glu  Pro Gln Val Ser Ser  Ser His Asn 
    4265                 4270                 4275             


Pro Thr  Ser Thr Glu Glu Gln  Gln Leu Tyr Trp Ala  Lys Gly Thr 
    4280                 4285                 4290             


Gly Phe  Gly Thr Gly Ser Thr  Ala Ser Gly Trp Asp  Val Glu Gln 
    4295                 4300                 4305             


Ala Leu  Thr Lys Gln Arg Leu  Glu Glu Glu His Val  Thr Cys Leu 
    4310                 4315                 4320             


Leu Gln  Val Leu Ala Ser Tyr  Ile Asn Pro Val Ser  Ser Ala Val 
    4325                 4330                 4335             


Asn Gly  Glu Ala Gln Ser Ser  His Glu Thr Arg Gly  Gln Asn Ser 
    4340                 4345                 4350             


Asn Ala  Leu Pro Ser Val Leu  Leu Glu Leu Leu Ser  Gln Ser Cys 
    4355                 4360                 4365             


Leu Ile  Pro Ala Met Ser Ser  Tyr Leu Arg Asn Asp  Ser Val Leu 
    4370                 4375                 4380             


Asp Met  Ala Arg His Val Pro  Leu Tyr Arg Ala Leu  Leu Glu Leu 
    4385                 4390                 4395             


Leu Arg  Ala Ile Ala Ser Cys  Ala Ala Met Val Pro  Leu Leu Leu 
    4400                 4405                 4410             


Pro Leu  Ser Thr Glu Asn Gly  Glu Glu Glu Glu Glu  Gln Ser Glu 
    4415                 4420                 4425             


Cys Gln  Thr Ser Val Gly Thr  Leu Leu Ala Lys Met  Lys Thr Cys 
    4430                 4435                 4440             


Val Asp  Thr Tyr Thr Asn Arg  Leu Arg Ser Lys Arg  Glu Asn Val 
    4445                 4450                 4455             


Lys Thr  Gly Val Lys Pro Asp  Ala Ser Asp Gln Glu  Pro Glu Gly 
    4460                 4465                 4470             


Leu Thr  Leu Leu Val Pro Asp  Ile Gln Lys Thr Ala  Glu Ile Val 
    4475                 4480                 4485             


Tyr Ala  Ala Thr Thr Ser Leu  Arg Gln Ala Asn Gln  Glu Lys Lys 
    4490                 4495                 4500             


Leu Gly  Glu Tyr Ser Lys Lys  Ala Ala Met Lys Pro  Lys Pro Leu 
    4505                 4510                 4515             


Ser Val  Leu Lys Ser Leu Glu  Glu Lys Tyr Val Ala  Val Met Lys 
    4520                 4525                 4530             


Lys Leu  Gln Phe Asp Thr Phe  Glu Met Val Ser Glu  Asp Glu Asp 
    4535                 4540                 4545             


Gly Lys  Leu Gly Phe Lys Val  Asn Tyr His Tyr Met  Ser Gln Val 
    4550                 4555                 4560             


Lys Asn  Ala Asn Asp Ala Asn  Ser Ala Ala Arg Ala  Arg Arg Leu 
    4565                 4570                 4575             


Ala Gln  Glu Ala Val Thr Leu  Ser Thr Ser Leu Pro  Leu Ser Ser 
    4580                 4585                 4590             


Ser Ser  Ser Val Phe Val Arg  Cys Asp Glu Glu Arg  Leu Asp Ile 
    4595                 4600                 4605             


Met Lys  Val Leu Ile Thr Gly  Pro Ala Asp Thr Pro  Tyr Ala Asn 
    4610                 4615                 4620             


Gly Cys  Phe Glu Phe Asp Val  Tyr Phe Pro Gln Asp  Tyr Pro Ser 
    4625                 4630                 4635             


Ser Pro  Pro Leu Val Asn Leu  Glu Thr Thr Gly Gly  His Ser Val 
    4640                 4645                 4650             


Arg Phe  Asn Pro Asn Leu Tyr  Asn Asp Gly Lys Val  Cys Leu Ser 
    4655                 4660                 4665             


Ile Leu  Asn Thr Trp His Gly  Arg Pro Glu Glu Lys  Trp Asn Pro 
    4670                 4675                 4680             


Gln Thr  Ser Ser Phe Leu Gln  Val Leu Val Ser Val  Gln Ser Leu 
    4685                 4690                 4695             


Ile Leu  Val Ala Glu Pro Tyr  Phe Asn Glu Pro Gly  Tyr Glu Arg 
    4700                 4705                 4710             


Ser Arg  Gly Thr Pro Ser Gly  Thr Gln Ser Ser Arg  Glu Tyr Asp 
    4715                 4720                 4725             


Gly Asn  Ile Arg Gln Ala Thr  Val Lys Trp Ala Met  Leu Glu Gln 
    4730                 4735                 4740             


Ile Arg  Asn Pro Ser Pro Cys  Phe Lys Glu Val Ile  His Lys His 
    4745                 4750                 4755             


Phe Tyr  Leu Lys Arg Val Glu  Ile Met Ala Gln Cys  Glu Glu Trp 
    4760                 4765                 4770             


Ile Ala  Asp Ile Gln Gln Tyr  Ser Ser Asp Lys Arg  Val Gly Arg 
    4775                 4780                 4785             


Thr Met  Ser His His Ala Ala  Ala Leu Lys Arg His  Thr Ala Gln 
    4790                 4795                 4800             


Leu Arg  Glu Glu Leu Leu Lys  Leu Pro Cys Pro Glu  Gly Leu Asp 
    4805                 4810                 4815             


Pro Asp  Thr Asp Asp Ala Pro  Glu Val Cys Arg Ala  Thr Thr Gly 
    4820                 4825                 4830             


Ala Glu  Glu Thr Leu Met His  Asp Gln Val Lys Pro  Ser Ser Ser 
    4835                 4840                 4845             


Lys Glu  Leu Pro Ser Asp Phe  Gln Leu 
    4850                 4855         


<210>  38
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Thr Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Thr Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Thr Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Thr Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Gly Val Ser Pro Ala Glu Ala 
    210                 215                 220                 


Gln Arg Ala Trp Trp Val Leu Glu Pro Pro Gly Ala Arg Asp Val Glu 
225                 230                 235                 240 


Ala Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu 
                245                 250                 255     


Asp Arg Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys 
            260                 265                 270         


Ala Glu Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro 
        275                 280                 285             


Val Arg Ser Arg Val Arg Thr Phe Leu Ser 
    290                 295             


<210>  39
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Thr Gly Tyr Glu Ala Arg Leu Ile Thr Phe Gly Thr Trp Met Tyr 
1               5                   10                  15      


Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly Phe Tyr Ala Ile Gly 
            20                  25                  30          


Gln Glu Asp Lys Val Gln Cys Phe His Cys Gly Gly Gly Leu Ala Asn 
        35                  40                  45              


Trp Lys Pro Lys Glu Asp Pro Trp Glu Gln His Ala Lys Trp Tyr Pro 
    50                  55                  60                  


Gly Cys Lys Tyr Leu Leu Glu Glu Lys Gly His Glu Tyr Ile Asn Asn 
65                  70                  75                  80  


Ile His Leu Thr Arg Ser Leu Glu Gly Ala Leu Val Gln Thr Thr Lys 
                85                  90                  95      


Lys Thr Pro Ser Leu Thr Lys Arg Ile Ser Asp Thr Ile Phe Pro Asn 
            100                 105                 110         


Pro Met Leu Gln Glu Ala Ile Arg Met Gly Phe Asp Phe Lys Asp Val 
        115                 120                 125             


Lys Lys Ile Met Glu Glu Arg Ile Gln Thr Ser Gly Ser Asn Tyr Lys 
    130                 135                 140                 


Thr Leu Glu Val Leu Val Ala Asp Leu Val Ser Ala Gln Lys Asp Thr 
145                 150                 155                 160 


Thr Glu Asn Glu Leu Asn Gln Thr Ser Leu Gln Arg Glu Ile Ser Pro 
                165                 170                 175     


Glu Glu Pro Leu Arg Arg Leu Gln Glu Glu Lys Leu Cys Lys Ile Cys 
            180                 185                 190         


Met Asp Arg His Ile Ala Val Val Phe Ile Pro Cys Gly His Leu Val 
        195                 200                 205             


Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Arg Cys Pro Met Cys Ser 
    210                 215                 220                 


Ala Val Ile Asp Phe Lys Gln Arg Val Phe Met Ser 
225                 230                 235     


<210>  40
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gln Pro Asp Pro Arg Pro Ser Gly Ala Gly Ala Cys Cys Arg Phe 
1               5                   10                  15      


Leu Pro Leu Gln Ser Gln Cys Pro Glu Gly Ala Gly Asp Ala Val Met 
            20                  25                  30          


Tyr Ala Ser Thr Glu Cys Lys Ala Glu Val Thr Pro Ser Gln His Gly 
        35                  40                  45              


Asn Arg Thr Phe Ser Tyr Thr Leu Glu Asp His Thr Lys Gln Ala Phe 
    50                  55                  60                  


Gly Ile Met Asn Glu Leu Arg Leu Ser Gln Gln Leu Cys Asp Val Thr 
65                  70                  75                  80  


Leu Gln Val Lys Tyr Gln Asp Ala Pro Ala Ala Gln Phe Met Ala His 
                85                  90                  95      


Lys Val Val Leu Ala Ser Ser Ser Pro Val Phe Lys Ala Met Phe Thr 
            100                 105                 110         


Asn Gly Leu Arg Glu Gln Gly Met Glu Val Val Ser Ile Glu Gly Ile 
        115                 120                 125             


His Pro Lys Val Met Glu Arg Leu Ile Glu Phe Ala Tyr Thr Ala Ser 
    130                 135                 140                 


Ile Ser Met Gly Glu Lys Cys Val Leu His Val Met Asn Gly Ala Val 
145                 150                 155                 160 


Met Tyr Gln Ile Asp Ser Val Val Arg Ala Cys Ser Asp Phe Leu Val 
                165                 170                 175     


Gln Gln Leu Asp Pro Ser Asn Ala Ile Gly Ile Ala Asn Phe Ala Glu 
            180                 185                 190         


Gln Ile Gly Cys Val Glu Leu His Gln Arg Ala Arg Glu Tyr Ile Tyr 
        195                 200                 205             


Met His Phe Gly Glu Val Ala Lys Gln Glu Glu Phe Phe Asn Leu Ser 
    210                 215                 220                 


His Cys Gln Leu Val Thr Leu Ile Ser Arg Asp Asp Leu Asn Val Arg 
225                 230                 235                 240 


Cys Glu Ser Glu Val Phe His Ala Cys Ile Asn Trp Val Lys Tyr Asp 
                245                 250                 255     


Cys Glu Gln Arg Arg Phe Tyr Val Gln Ala Leu Leu Arg Ala Val Arg 
            260                 265                 270         


Cys His Ser Leu Thr Pro Asn Phe Leu Gln Met Gln Leu Gln Lys Cys 
        275                 280                 285             


Glu Ile Leu Gln Ser Asp Ser Arg Cys Lys Asp Tyr Leu Val Lys Ile 
    290                 295                 300                 


Phe Glu Glu Leu Thr Leu His Lys Pro Thr Gln Val Met Pro Cys Arg 
305                 310                 315                 320 


Ala Pro Lys Val Gly Arg Leu Ile Tyr Thr Ala Gly Gly Tyr Phe Arg 
                325                 330                 335     


Gln Ser Leu Ser Tyr Leu Glu Ala Tyr Asn Pro Ser Asp Gly Thr Trp 
            340                 345                 350         


Leu Arg Leu Ala Asp Leu Gln Val Pro Arg Ser Gly Leu Ala Gly Cys 
        355                 360                 365             


Val Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Arg Asn Asn Ser Pro 
    370                 375                 380                 


Asp Gly Asn Thr Asp Ser Ser Ala Leu Asp Cys Tyr Asn Pro Met Thr 
385                 390                 395                 400 


Asn Gln Trp Ser Pro Cys Ala Pro Met Ser Val Pro Arg Asn Arg Ile 
                405                 410                 415     


Gly Val Gly Val Ile Asp Gly His Ile Tyr Ala Val Gly Gly Ser His 
            420                 425                 430         


Gly Cys Ile His His Asn Ser Val Glu Arg Tyr Glu Pro Glu Arg Asp 
        435                 440                 445             


Glu Trp His Leu Val Ala Pro Met Leu Thr Arg Arg Ile Gly Val Gly 
    450                 455                 460                 


Val Ala Val Leu Asn Arg Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly 
465                 470                 475                 480 


Thr Asn Arg Leu Asn Ser Ala Glu Cys Tyr Tyr Pro Glu Arg Asn Glu 
                485                 490                 495     


Trp Arg Met Ile Thr Ala Met Asn Thr Ile Arg Ser Gly Ala Gly Val 
            500                 505                 510         


Cys Val Leu His Asn Cys Ile Tyr Ala Ala Gly Gly Tyr Asp Gly Gln 
        515                 520                 525             


Asp Gln Leu Asn Ser Val Glu Arg Tyr Asp Val Glu Thr Glu Thr Trp 
    530                 535                 540                 


Thr Phe Val Ala Pro Met Lys His Arg Arg Ser Ala Leu Gly Ile Thr 
545                 550                 555                 560 


Val His Gln Gly Arg Ile Tyr Val Leu Gly Gly Tyr Asp Gly His Thr 
                565                 570                 575     


Phe Leu Asp Ser Val Glu Cys Tyr Asp Pro Asp Thr Asp Thr Trp Ser 
            580                 585                 590         


Glu Val Thr Arg Met Thr Ser Gly Arg Ser Gly Val Gly Val Ala Val 
        595                 600                 605             


Thr Met Glu Pro Cys Arg Lys Gln Ile Asp Gln Gln Asn Cys Thr Cys 
    610                 615                 620                 


<210>  41
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Pro Ser Ser Lys Ser Glu Arg Asn Ser Gly Ala Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Pro Gly Gly Ala Gly Gly Lys Arg Ala Ala Gly Arg Arg 
            20                  25                  30          


Arg Glu His Val Leu Lys Gln Leu Glu Arg Val Lys Ile Ser Gly Gln 
        35                  40                  45              


Leu Ser Pro Arg Leu Phe Arg Lys Leu Pro Pro Arg Val Cys Val Ser 
    50                  55                  60                  


Leu Lys Asn Ile Val Asp Glu Asp Phe Leu Tyr Ala Gly His Ile Phe 
65                  70                  75                  80  


Leu Gly Phe Ser Lys Cys Gly Arg Tyr Val Leu Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Gly Asp Asp Asp Phe Ser Phe Tyr Ile Tyr His Leu Tyr Trp Trp 
            100                 105                 110         


Glu Phe Asn Val His Ser Lys Leu Lys Leu Val Arg Gln Val Arg Leu 
        115                 120                 125             


Phe Gln Asp Glu Glu Ile Tyr Ser Asp Leu Tyr Leu Thr Val Cys Glu 
    130                 135                 140                 


Trp Pro Ser Asp Ala Ser Lys Val Ile Val Phe Gly Phe Asn Thr Arg 
145                 150                 155                 160 


Ser Ala Asn Gly Met Leu Met Asn Met Met Met Met Ser Asp Glu Asn 
                165                 170                 175     


His Arg Asp Ile Tyr Val Ser Thr Val Ala Val Pro Pro Pro Gly Arg 
            180                 185                 190         


Cys Ala Ala Cys Gln Asp Ala Ser Arg Ala His Pro Gly Asp Pro Asn 
        195                 200                 205             


Ala Gln Cys Leu Arg His Gly Phe Met Leu His Thr Lys Tyr Gln Val 
    210                 215                 220                 


Val Tyr Pro Phe Pro Thr Phe Gln Pro Ala Phe Gln Leu Lys Lys Asp 
225                 230                 235                 240 


Gln Val Val Leu Leu Asn Thr Ser Tyr Ser Leu Val Ala Cys Ala Val 
                245                 250                 255     


Ser Val His Ser Ala Gly Asp Arg Ser Phe Cys Gln Ile Leu Tyr Asp 
            260                 265                 270         


His Ser Thr Cys Pro Leu Ala Pro Ala Ser Pro Pro Glu Pro Gln Ser 
        275                 280                 285             


Pro Glu Leu Pro Pro Ala Leu Pro Ser Phe Cys Pro Glu Ala Ala Pro 
    290                 295                 300                 


Ala Arg Ser Ser Gly Ser Pro Glu Pro Ser Pro Ala Ile Ala Lys Ala 
305                 310                 315                 320 


Lys Glu Phe Val Ala Asp Ile Phe Arg Arg Ala Lys Glu Ala Lys Gly 
                325                 330                 335     


Gly Val Pro Glu Glu Ala Arg Pro Ala Leu Cys Pro Gly Pro Ser Gly 
            340                 345                 350         


Ser Arg Cys Arg Ala His Ser Glu Pro Leu Ala Leu Cys Gly Glu Thr 
        355                 360                 365             


Ala Pro Arg Asp Ser Pro Pro Ala Ser Glu Ala Pro Ala Ser Glu Pro 
    370                 375                 380                 


Gly Tyr Val Asn Tyr Thr Lys Leu Tyr Tyr Val Leu Glu Ser Gly Glu 
385                 390                 395                 400 


Gly Thr Glu Pro Glu Asp Glu Leu Glu Asp Asp Lys Ile Ser Leu Pro 
                405                 410                 415     


Phe Val Val Thr Asp Leu Arg Gly Arg Asn Leu Arg Pro Met Arg Glu 
            420                 425                 430         


Arg Thr Ala Val Gln Gly Gln Tyr Leu Thr Val Glu Gln Leu Thr Leu 
        435                 440                 445             


Asp Phe Glu Tyr Val Ile Asn Glu Val Ile Arg His Asp Ala Thr Trp 
    450                 455                 460                 


Gly His Gln Phe Cys Ser Phe Ser Asp Tyr Asp Ile Val Ile Leu Glu 
465                 470                 475                 480 


Val Cys Pro Glu Thr Asn Gln Val Leu Ile Asn Ile Gly Leu Leu Leu 
                485                 490                 495     


Leu Ala Phe Pro Ser Pro Thr Glu Glu Gly Gln Leu Arg Pro Lys Thr 
            500                 505                 510         


Tyr His Thr Ser Leu Lys Val Ala Trp Asp Leu Asn Thr Gly Ile Phe 
        515                 520                 525             


Glu Thr Val Ser Val Gly Asp Leu Thr Glu Val Lys Gly Gln Thr Ser 
    530                 535                 540                 


Gly Ser Val Trp Ser Ser Tyr Arg Lys Ser Cys Val Asp Met Val Met 
545                 550                 555                 560 


Lys Trp Leu Val Pro Glu Ser Ser Gly Arg Tyr Val Asn Arg Met Thr 
                565                 570                 575     


Asn Glu Ala Leu His Lys Gly Cys Ser Leu Lys Val Leu Ala Asp Ser 
            580                 585                 590         


Glu Arg Tyr Thr Trp Ile Val Leu 
        595                 600 


<210>  42
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Thr Arg Lys Arg Arg Gly Gly Ala Ile Asn Ser Arg Gln Ala 
1               5                   10                  15      


Gln Lys Arg Thr Arg Glu Ala Thr Ser Thr Pro Glu Ile Ser Leu Glu 
            20                  25                  30          


Ala Glu Pro Ile Glu Leu Val Glu Thr Ala Gly Asp Glu Ile Val Asp 
        35                  40                  45              


Leu Thr Cys Glu Ser Leu Glu Pro Val Val Val Asp Leu Thr His Asn 
    50                  55                  60                  


Asp Ser Val Val Ile Val Asp Glu Arg Arg Arg Pro Arg Arg Asn Ala 
65                  70                  75                  80  


Arg Arg Leu Pro Gln Asp His Ala Asp Ser Cys Val Val Ser Ser Asp 
                85                  90                  95      


Asp Glu Glu Leu Ser Arg Asp Arg Asp Val Tyr Val Thr Thr His Thr 
            100                 105                 110         


Pro Arg Asn Ala Arg Asp Glu Gly Ala Thr Gly Leu Arg Pro Ser Gly 
        115                 120                 125             


Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile Val Gln 
    130                 135                 140                 


Asn Gly Arg Leu Ile Val Ser Thr Glu Cys Gly His Val Phe Cys Ser 
145                 150                 155                 160 


Gln Cys Leu Arg Asp Ser Leu Lys Asn Ala Asn Thr Cys Pro Thr Cys 
                165                 170                 175     


Arg Lys Lys Ile Asn His Lys Arg Tyr His Pro Ile Tyr Ile 
            180                 185                 190 


<210>  43
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Thr Arg Lys Arg Arg Gly Gly Ala Ile Asn Ser Arg Gln Ala 
1               5                   10                  15      


Gln Lys Arg Thr Arg Glu Ala Thr Ser Thr Pro Glu Ile Ser Leu Glu 
            20                  25                  30          


Ala Glu Pro Ile Glu Leu Val Glu Thr Ala Gly Asp Glu Ile Val Asp 
        35                  40                  45              


Leu Thr Cys Glu Ser Leu Glu Pro Val Val Val Asp Leu Thr His Asn 
    50                  55                  60                  


Asp Ser Val Val Ile Val Asp Gly Pro Gln Val Leu Ser Val Val Pro 
65                  70                  75                  80  


Ser Ala Trp Thr Asp Thr Gln Arg Ser Cys Arg Met Asp Val Ser Ser 
                85                  90                  95      


Phe Pro Gln Asn Ala Ala Met Ser Ser Val Ala Ser Ala Ser Val Ile 
            100                 105                 110         


Pro 
    


<210>  44
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Ala Gln Gln Arg Asp Cys Gly Gly Ala Ala Gln Leu Ala Gly 
1               5                   10                  15      


Pro Ala Ala Glu Ala Asp Pro Leu Gly Arg Phe Thr Cys Pro Val Cys 
            20                  25                  30          


Leu Glu Val Tyr Glu Lys Pro Val Gln Val Pro Cys Gly His Val Phe 
        35                  40                  45              


Cys Ser Ala Cys Leu Gln Glu Cys Leu Lys Pro Lys Lys Pro Val Cys 
    50                  55                  60                  


Gly Val Cys Arg Ser Ala Leu Ala Pro Gly Val Arg Ala Val Glu Leu 
65                  70                  75                  80  


Glu Arg Gln Ile Glu Ser Thr Glu Thr Ser Cys His Gly Cys Arg Lys 
                85                  90                  95      


Asn Phe Phe Leu Ser Lys Ile Arg Ser His Val Ala Thr Cys Ser Lys 
            100                 105                 110         


Tyr Gln Asn Tyr Ile Met Glu Gly Val Lys Ala Thr Ile Lys Asp Ala 
        115                 120                 125             


Ser Leu Gln Pro Arg Asn Val Pro Asn Arg Tyr Thr Phe Pro Cys Pro 
    130                 135                 140                 


Tyr Cys Pro Glu Lys Asn Phe Asp Gln Glu Gly Leu Val Glu His Cys 
145                 150                 155                 160 


Lys Leu Phe His Ser Thr Asp Thr Lys Ser Val Val Cys Pro Ile Cys 
                165                 170                 175     


Ala Ser Met Pro Trp Gly Asp Pro Asn Tyr Arg Ser Ala Asn Phe Arg 
            180                 185                 190         


Glu His Ile Gln Arg Arg His Arg Phe Ser Tyr Asp Thr Phe Val Asp 
        195                 200                 205             


Tyr Asp Val Asp Glu Glu Asp Met Met Asn Gln Val Leu Gln Arg Ser 
    210                 215                 220                 


Ile Ile Asp Gln 
225             


<210>  45
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Ala Gln Gln Arg Asp Cys Gly Gly Ala Ala Gln Leu Ala Gly 
1               5                   10                  15      


Pro Ala Ala Glu Ala Asp Pro Leu Gly Arg Phe Thr Cys Pro Val Cys 
            20                  25                  30          


Leu Glu Val Tyr Glu Lys Pro Val Gln Val Pro Cys Gly His Val Phe 
        35                  40                  45              


Cys Ser Ala Cys Leu Gln Glu Cys Leu Lys Pro Lys Lys Pro Val Cys 
    50                  55                  60                  


Gly Val Cys Arg Ser Ala Leu Ala Pro Gly Val Arg Ala Val Glu Leu 
65                  70                  75                  80  


Glu Arg Gln Ile Glu Ser Thr Glu Thr Ser Cys His Gly Cys Arg Lys 
                85                  90                  95      


Asn Phe Phe Leu Ser Lys Ile Arg Ser His Val Ala Thr Cys Ser Lys 
            100                 105                 110         


Tyr Gln Asn Tyr Ile Met Glu Gly Val Lys Ala Thr Ile Lys Asp Ala 
        115                 120                 125             


Ser Leu Gln Pro Arg Asn Val Pro Asn Arg Tyr Thr Phe Pro Cys Pro 
    130                 135                 140                 


Tyr Cys Pro Glu Lys Asn Phe Asp Gln Glu Gly Leu Val Glu His Cys 
145                 150                 155                 160 


Lys Leu Phe His Ser Thr Asp Thr Lys Ser Val Val Ser Glu Gln Ser 
                165                 170                 175     


Pro Cys Leu Leu Ser Val Ser Cys Tyr Arg Ala Ser Ile Thr Tyr 
            180                 185                 190     


<210>  46
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gly Pro Arg Asn Pro Ser Pro Asp His Leu Ser Glu Ser Glu Ser 
1               5                   10                  15      


Glu Glu Glu Glu Asn Ile Ser Tyr Leu Asn Glu Ser Ser Gly Glu Glu 
            20                  25                  30          


Trp Asp Ser Ser Glu Glu Glu Asp Ser Met Val Pro Asn Leu Ser Pro 
        35                  40                  45              


Leu Glu Ser Leu Ala Trp Gln Val Lys Cys Leu Leu Lys Tyr Ser Thr 
    50                  55                  60                  


Thr Trp Lys Pro Leu Asn Pro Asn Ser Trp Leu Tyr His Ala Lys Leu 
65                  70                  75                  80  


Leu Asp Pro Ser Thr Pro Val His Ile Leu Arg Glu Ile Gly Leu Arg 
                85                  90                  95      


Leu Ser His Cys Ser His Cys Val Pro Lys Leu Glu Pro Ile Pro Glu 
            100                 105                 110         


Trp Pro Pro Leu Ala Ser Cys Gly Val Pro Pro Phe Gln Lys Pro Leu 
        115                 120                 125             


Thr Ser Pro Ser Arg Leu Ser Arg Asp His Ala Thr Leu Asn Gly Ala 
    130                 135                 140                 


Leu Gln Phe Ala Thr Lys Gln Leu Ser Arg Thr Leu Ser Arg Ala Thr 
145                 150                 155                 160 


Pro Ile Pro Glu Tyr Leu Lys Gln Ile Pro Asn Ser Cys Val Ser Gly 
                165                 170                 175     


Cys Cys Cys Gly Trp Leu Thr Lys Thr Val Lys Glu Thr Thr Arg Thr 
            180                 185                 190         


Glu Pro Ile Asn Thr Thr Tyr Ser Tyr Thr Asp Phe Gln Lys Ala Val 
        195                 200                 205             


Asn Lys Leu Leu Thr Ala Ser Leu 
    210                 215     


<210>  47
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Asn Ser Ser Ser Ala Asn Ile Thr Tyr Ala Ser Arg Lys Arg Arg 
1               5                   10                  15      


Lys Pro Val Gln Lys Thr Val Lys Pro Ile Pro Ala Glu Gly Ile Lys 
            20                  25                  30          


Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Thr Glu Leu Asp 
        35                  40                  45              


Arg Leu Ala Ser Leu Leu Pro Phe Pro Gln Asp Val Ile Asn Lys Leu 
    50                  55                  60                  


Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Ala Lys 
65                  70                  75                  80  


Ser Phe Phe Asp Val Ala Leu Lys Ser Ser Pro Thr Glu Arg Asn Gly 
                85                  90                  95      


Gly Gln Asp Asn Cys Arg Ala Ala Asn Phe Arg Glu Gly Leu Asn Leu 
            100                 105                 110         


Gln Glu Gly Glu Phe Leu Leu Gln Ala Leu Asn Gly Phe Val Leu Val 
        115                 120                 125             


Val Thr Thr Asp Ala Leu Val Phe Tyr Ala Ser Ser Thr Ile Gln Asp 
    130                 135                 140                 


Tyr Leu Gly Phe Gln Gln Ser Asp Val Ile His Gln Ser Val Tyr Glu 
145                 150                 155                 160 


Leu Ile His Thr Glu Asp Arg Ala Glu Phe Gln Arg Gln Leu His Trp 
                165                 170                 175     


Ala Leu Asn Pro Ser Gln Cys Thr Glu Ser Gly Gln Gly Ile Glu Glu 
            180                 185                 190         


Ala Thr Gly Leu Pro Gln Thr Val Val Cys Tyr Asn Pro Asp Gln Ile 
        195                 200                 205             


Pro Pro Glu Asn Ser Pro Leu Met Glu Arg Cys Phe Ile Cys Arg Leu 
    210                 215                 220                 


Arg Cys Leu Leu Asp Asn Ser Ser Gly Phe Leu Ala Met Asn Phe Gln 
225                 230                 235                 240 


Gly Lys Leu Lys Tyr Leu His Gly Gln Lys Lys Lys Gly Lys Asp Gly 
                245                 250                 255     


Ser Ile Leu Pro Pro Gln Leu Ala Leu Phe Ala Ile Ala Thr Pro Leu 
            260                 265                 270         


Gln Pro Pro Ser Ile Leu Glu Ile Arg Thr Lys Asn Phe Ile Phe Arg 
        275                 280                 285             


Thr Lys His Lys Leu Asp Phe Thr Pro Ile Gly Cys Asp Ala Lys Gly 
    290                 295                 300                 


Arg Ile Val Leu Gly Tyr Thr Glu Ala Glu Leu Cys Thr Arg Gly Ser 
305                 310                 315                 320 


Gly Tyr Gln Phe Ile His Ala Ala Asp Met Leu Tyr Cys Ala Glu Ser 
                325                 330                 335     


His Ile Arg Met Ile Lys Thr Gly Glu Ser Gly Met Ile Val Phe Arg 
            340                 345                 350         


Leu Leu Thr Lys Asn Asn Arg Trp Thr Trp Val Gln Ser Asn Ala Arg 
        355                 360                 365             


Leu Leu Tyr Lys Asn Gly Arg Pro Asp Tyr Ile Ile Val Thr Gln Arg 
    370                 375                 380                 


Pro Leu Thr Asp Glu Glu Gly Thr Glu His Leu Arg Lys Arg Asn Thr 
385                 390                 395                 400 


Lys Leu Pro Phe Met Phe Thr Thr Gly Glu Ala Val Leu Tyr Glu Ala 
                405                 410                 415     


Thr Asn Pro Phe Pro Ala Ile Met Asp Pro Leu Pro Leu Arg Thr Lys 
            420                 425                 430         


Asn Gly Thr Ser Gly Lys Asp Ser Ala Thr Thr Ser Thr Leu Ser Lys 
        435                 440                 445             


Asp Ser Leu Asn Pro Ser Ser Leu Leu Ala Ala Met Met Gln Gln Asp 
    450                 455                 460                 


Glu Ser Ile Tyr Leu Tyr Pro Ala Ser Ser Thr Ser Ser Thr Ala Pro 
465                 470                 475                 480 


Phe Glu Asn Asn Phe Phe Asn Glu Ser Met Asn Glu Cys Arg Asn Trp 
                485                 490                 495     


Gln Asp Asn Thr Ala Pro Met Gly Asn Asp Thr Ile Leu Lys His Glu 
            500                 505                 510         


Gln Ile Asp Gln Pro Gln Asp Val Asn Ser Phe Ala Gly Gly His Pro 
        515                 520                 525             


Gly Leu Phe Gln Asp Ser Lys Asn Ser Asp Leu Tyr Ser Ile Met Lys 
    530                 535                 540                 


Asn Leu Gly Ile Asp Phe Glu Asp Ile Arg His Met Gln Asn Glu Lys 
545                 550                 555                 560 


Phe Phe Arg Asn Asp Phe Ser Gly Glu Val Asp Phe Arg Asp Ile Asp 
                565                 570                 575     


Leu Thr Asp Glu Ile Leu Thr Tyr Val Gln Asp Ser Leu Ser Lys Ser 
            580                 585                 590         


Pro Phe Ile Pro Ser Asp Tyr Gln Gln Gln Gln Ser Leu Ala Leu Asn 
        595                 600                 605             


Ser Ser Cys Met Val Gln Glu His Leu His Leu Glu Gln Gln Gln Gln 
    610                 615                 620                 


His His Gln Lys Gln Val Val Val Glu Pro Gln Gln Gln Leu Cys Gln 
625                 630                 635                 640 


Lys Met Lys His Met Gln Val Asn Gly Met Phe Glu Asn Trp Asn Ser 
                645                 650                 655     


Asn Gln Phe Val Pro Phe Asn Cys Pro Gln Gln Asp Pro Gln Gln Tyr 
            660                 665                 670         


Asn Val Phe Thr Asp Leu His Gly Ile Ser Gln Glu Phe Pro Tyr Lys 
        675                 680                 685             


Ser Glu Met Asp Ser Met Pro Tyr Thr Gln Asn Phe Ile Ser Cys Asn 
    690                 695                 700                 


Gln Pro Val Leu Pro Gln His Ser Lys Cys Thr Glu Leu Asp Tyr Pro 
705                 710                 715                 720 


Met Gly Ser Phe Glu Pro Ser Pro Tyr Pro Thr Thr Ser Ser Leu Glu 
                725                 730                 735     


Asp Phe Val Thr Cys Leu Gln Leu Pro Glu Asn Gln Lys His Gly Leu 
            740                 745                 750         


Asn Pro Gln Ser Ala Ile Ile Thr Pro Gln Thr Cys Tyr Ala Gly Ala 
        755                 760                 765             


Val Ser Met Tyr Gln Cys Gln Pro Glu Pro Gln His Thr His Val Gly 
    770                 775                 780                 


Gln Met Gln Tyr Asn Pro Val Leu Pro Gly Gln Gln Ala Phe Leu Asn 
785                 790                 795                 800 


Lys Phe Gln Asn Gly Val Leu Asn Glu Thr Tyr Pro Ala Glu Leu Asn 
                805                 810                 815     


Asn Ile Asn Asn Thr Gln Thr Thr Thr His Leu Gln Pro Leu His His 
            820                 825                 830         


Pro Ser Glu Ala Arg Pro Phe Pro Asp Leu Thr Ser Ser Gly Phe Leu 
        835                 840                 845             


<210>  48
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210>  49
<211>  1755
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Ser Glu Leu Glu Pro Glu Val Gln Ala Ile Asp Arg Ser Leu 
1               5                   10                  15      


Leu Glu Cys Ser Ala Glu Glu Ile Ala Gly Lys Trp Leu Gln Ala Thr 
            20                  25                  30          


Asp Leu Thr Arg Glu Val Tyr Gln His Leu Ala His Tyr Val Pro Lys 
        35                  40                  45              


Ile Tyr Cys Arg Gly Pro Asn Pro Phe Pro Gln Lys Glu Asp Met Leu 
    50                  55                  60                  


Ala Gln His Val Leu Leu Gly Pro Met Glu Trp Tyr Leu Cys Gly Glu 
65                  70                  75                  80  


Asp Pro Ala Phe Gly Phe Pro Lys Leu Glu Gln Ala Asn Lys Pro Ser 
                85                  90                  95      


His Leu Cys Gly Arg Val Phe Lys Val Gly Glu Pro Thr Tyr Ser Cys 
            100                 105                 110         


Arg Asp Cys Ala Val Asp Pro Thr Cys Val Leu Cys Met Glu Cys Phe 
        115                 120                 125             


Leu Gly Ser Ile His Arg Asp His Arg Tyr Arg Met Thr Thr Ser Gly 
    130                 135                 140                 


Gly Gly Gly Phe Cys Asp Cys Gly Asp Thr Glu Ala Trp Lys Glu Gly 
145                 150                 155                 160 


Pro Tyr Cys Gln Lys His Glu Leu Asn Thr Ser Glu Ile Glu Glu Glu 
                165                 170                 175     


Glu Asp Pro Leu Val His Leu Ser Glu Asp Val Ile Ala Arg Thr Tyr 
            180                 185                 190         


Asn Ile Phe Ala Ile Thr Phe Arg Tyr Ala Val Glu Ile Leu Thr Trp 
        195                 200                 205             


Glu Lys Glu Ser Glu Leu Pro Ala Asp Leu Glu Met Val Glu Lys Ser 
    210                 215                 220                 


Asp Thr Tyr Tyr Cys Met Leu Phe Asn Asp Glu Val His Thr Tyr Glu 
225                 230                 235                 240 


Gln Val Ile Tyr Thr Leu Gln Lys Ala Val Asn Cys Thr Gln Lys Glu 
                245                 250                 255     


Ala Ile Gly Phe Ala Thr Thr Val Asp Arg Asp Gly Arg Arg Ser Val 
            260                 265                 270         


Arg Tyr Gly Asp Phe Gln Tyr Cys Glu Gln Ala Lys Ser Val Ile Val 
        275                 280                 285             


Arg Asn Thr Ser Arg Gln Thr Lys Pro Leu Lys Val Gln Val Met His 
    290                 295                 300                 


Ser Ser Ile Val Ala His Gln Asn Phe Gly Leu Lys Leu Leu Ser Trp 
305                 310                 315                 320 


Leu Gly Ser Ile Ile Gly Tyr Ser Asp Gly Leu Arg Arg Ile Leu Cys 
                325                 330                 335     


Gln Val Gly Leu Gln Glu Gly Pro Asp Gly Glu Asn Ser Ser Leu Val 
            340                 345                 350         


Asp Arg Leu Met Leu Ser Asp Ser Lys Leu Trp Lys Gly Ala Arg Ser 
        355                 360                 365             


Val Tyr His Gln Leu Phe Met Ser Ser Leu Leu Met Asp Leu Lys Tyr 
    370                 375                 380                 


Lys Lys Leu Phe Ala Val Arg Phe Ala Lys Asn Tyr Gln Gln Leu Gln 
385                 390                 395                 400 


Arg Asp Phe Met Glu Asp Asp His Glu Arg Ala Val Ser Val Thr Ala 
                405                 410                 415     


Leu Ser Val Gln Phe Phe Thr Ala Pro Thr Leu Ala Arg Met Leu Ile 
            420                 425                 430         


Thr Glu Glu Asn Leu Met Ser Ile Ile Ile Lys Thr Phe Met Asp His 
        435                 440                 445             


Leu Arg His Arg Asp Ala Gln Gly Arg Phe Gln Phe Glu Arg Tyr Thr 
    450                 455                 460                 


Ala Leu Gln Ala Phe Lys Phe Arg Arg Val Gln Ser Leu Ile Leu Asp 
465                 470                 475                 480 


Leu Lys Tyr Val Leu Ile Ser Lys Pro Thr Glu Trp Ser Asp Glu Leu 
                485                 490                 495     


Arg Gln Lys Phe Leu Glu Gly Phe Asp Ala Phe Leu Glu Leu Leu Lys 
            500                 505                 510         


Cys Met Gln Gly Met Asp Pro Ile Thr Arg Gln Val Gly Gln His Ile 
        515                 520                 525             


Glu Met Glu Pro Glu Trp Glu Ala Ala Phe Thr Leu Gln Met Lys Leu 
    530                 535                 540                 


Thr His Val Ile Ser Met Met Gln Asp Trp Cys Ala Ser Asp Glu Lys 
545                 550                 555                 560 


Val Leu Ile Glu Ala Tyr Lys Lys Cys Leu Ala Val Leu Met Gln Cys 
                565                 570                 575     


His Gly Gly Tyr Thr Asp Gly Glu Gln Pro Ile Thr Leu Ser Ile Cys 
            580                 585                 590         


Gly His Ser Val Glu Thr Ile Arg Tyr Cys Val Ser Gln Glu Lys Val 
        595                 600                 605             


Ser Ile His Leu Pro Val Ser Arg Leu Leu Ala Gly Leu His Val Leu 
    610                 615                 620                 


Leu Ser Lys Ser Glu Val Ala Tyr Lys Phe Pro Glu Leu Leu Pro Leu 
625                 630                 635                 640 


Ser Glu Leu Ser Pro Pro Met Leu Ile Glu His Pro Leu Arg Cys Leu 
                645                 650                 655     


Val Leu Cys Ala Gln Val His Ala Gly Met Trp Arg Arg Asn Gly Phe 
            660                 665                 670         


Ser Leu Val Asn Gln Ile Tyr Tyr Tyr His Asn Val Lys Cys Arg Arg 
        675                 680                 685             


Glu Met Phe Asp Lys Asp Val Val Met Leu Gln Thr Gly Val Ser Met 
    690                 695                 700                 


Met Asp Pro Asn His Phe Leu Met Ile Met Leu Ser Arg Phe Glu Leu 
705                 710                 715                 720 


Tyr Gln Ile Phe Ser Thr Pro Asp Tyr Gly Lys Arg Phe Ser Ser Glu 
                725                 730                 735     


Ile Thr His Lys Asp Val Val Gln Gln Asn Asn Thr Leu Ile Glu Glu 
            740                 745                 750         


Met Leu Tyr Leu Ile Ile Met Leu Val Gly Glu Arg Phe Ser Pro Gly 
        755                 760                 765             


Val Gly Gln Val Asn Ala Thr Asp Glu Ile Lys Arg Glu Ile Ile His 
    770                 775                 780                 


Gln Leu Ser Ile Lys Pro Met Ala His Ser Glu Leu Val Lys Ser Leu 
785                 790                 795                 800 


Pro Glu Asp Glu Asn Lys Glu Thr Gly Met Glu Ser Val Ile Glu Ala 
                805                 810                 815     


Val Ala His Phe Lys Lys Pro Gly Leu Thr Gly Arg Gly Met Tyr Glu 
            820                 825                 830         


Leu Lys Pro Glu Cys Ala Lys Glu Phe Asn Leu Tyr Phe Tyr His Phe 
        835                 840                 845             


Ser Arg Ala Glu Gln Ser Lys Ala Glu Glu Ala Gln Arg Lys Leu Lys 
    850                 855                 860                 


Arg Gln Asn Arg Glu Asp Thr Ala Leu Pro Pro Pro Val Leu Pro Pro 
865                 870                 875                 880 


Phe Cys Pro Leu Phe Ala Ser Leu Val Asn Ile Leu Gln Ser Asp Val 
                885                 890                 895     


Met Leu Cys Ile Met Gly Thr Ile Leu Gln Trp Ala Val Glu His Asn 
            900                 905                 910         


Gly Tyr Ala Trp Ser Glu Ser Met Leu Gln Arg Val Leu His Leu Ile 
        915                 920                 925             


Gly Met Ala Leu Gln Glu Glu Lys Gln His Leu Glu Asn Val Thr Glu 
    930                 935                 940                 


Glu His Val Val Thr Phe Thr Phe Thr Gln Lys Ile Ser Lys Pro Gly 
945                 950                 955                 960 


Glu Ala Pro Lys Asn Ser Pro Ser Ile Leu Ala Met Leu Glu Thr Leu 
                965                 970                 975     


Gln Asn Ala Pro Tyr Leu Glu Val His Lys Asp Met Ile Arg Trp Ile 
            980                 985                 990         


Leu Lys Thr Phe Asn Ala Val Lys  Lys Met Arg Glu Ser  Ser Pro Thr 
        995                 1000                 1005             


Ser Pro  Val Ala Glu Thr Glu  Gly Thr Ile Met Glu  Glu Ser Ser 
    1010                 1015                 1020             


Arg Asp  Lys Asp Lys Ala Glu  Arg Lys Arg Lys Ala  Glu Ile Ala 
    1025                 1030                 1035             


Arg Leu  Arg Arg Glu Lys Ile  Met Ala Gln Met Ser  Glu Met Gln 
    1040                 1045                 1050             


Arg His  Phe Ile Asp Glu Asn  Lys Glu Leu Phe Gln  Gln Thr Leu 
    1055                 1060                 1065             


Glu Leu  Asp Ala Ser Thr Ser  Ala Val Leu Asp His  Ser Pro Val 
    1070                 1075                 1080             


Ala Ser  Asp Met Thr Leu Thr  Ala Leu Gly Pro Ala  Gln Thr Gln 
    1085                 1090                 1095             


Val Pro  Glu Gln Arg Gln Phe  Val Thr Cys Ile Leu  Cys Gln Glu 
    1100                 1105                 1110             


Glu Gln  Glu Val Lys Val Glu  Ser Arg Ala Met Val  Leu Ala Ala 
    1115                 1120                 1125             


Phe Val  Gln Arg Ser Thr Val  Leu Ser Lys Asn Arg  Ser Lys Phe 
    1130                 1135                 1140             


Ile Gln  Asp Pro Glu Lys Tyr  Asp Pro Leu Phe Met  His Pro Asp 
    1145                 1150                 1155             


Leu Ser  Cys Gly Thr His Thr  Ser Ser Cys Gly His  Ile Met His 
    1160                 1165                 1170             


Ala His  Cys Trp Gln Arg Tyr  Phe Asp Ser Val Gln  Ala Lys Glu 
    1175                 1180                 1185             


Gln Arg  Arg Gln Gln Arg Leu  Arg Leu His Thr Ser  Tyr Asp Val 
    1190                 1195                 1200             


Glu Asn  Gly Glu Phe Leu Cys  Pro Leu Cys Glu Cys  Leu Ser Asn 
    1205                 1210                 1215             


Thr Val  Ile Pro Leu Leu Leu  Pro Pro Arg Asn Ile  Phe Asn Asn 
    1220                 1225                 1230             


Arg Leu  Asn Phe Ser Asp Gln  Pro Asn Leu Thr Gln  Trp Ile Arg 
    1235                 1240                 1245             


Thr Ile  Ser Gln Gln Ile Lys  Ala Leu Gln Phe Leu  Arg Lys Glu 
    1250                 1255                 1260             


Glu Ser  Thr Pro Asn Asn Ala  Ser Thr Lys Asn Ser  Glu Asn Val 
    1265                 1270                 1275             


Asp Glu  Leu Gln Leu Pro Glu  Gly Phe Arg Pro Asp  Phe Arg Pro 
    1280                 1285                 1290             


Lys Ile  Pro Tyr Ser Glu Ser  Ile Lys Glu Met Leu  Thr Thr Phe 
    1295                 1300                 1305             


Gly Thr  Ala Thr Tyr Lys Val  Gly Leu Lys Val His  Pro Asn Glu 
    1310                 1315                 1320             


Glu Asp  Pro Arg Val Pro Ile  Met Cys Trp Gly Ser  Cys Ala Tyr 
    1325                 1330                 1335             


Thr Ile  Gln Ser Ile Glu Arg  Ile Leu Ser Asp Glu  Asp Lys Pro 
    1340                 1345                 1350             


Leu Phe  Gly Pro Leu Pro Cys  Arg Leu Asp Asp Cys  Leu Arg Ser 
    1355                 1360                 1365             


Leu Thr  Arg Phe Ala Ala Ala  His Trp Thr Val Ala  Ser Val Ser 
    1370                 1375                 1380             


Val Val  Gln Gly His Phe Cys  Lys Leu Phe Ala Ser  Leu Val Pro 
    1385                 1390                 1395             


Asn Asp  Ser His Glu Glu Leu  Pro Cys Ile Leu Asp  Ile Asp Met 
    1400                 1405                 1410             


Phe His  Leu Leu Val Gly Leu  Val Leu Ala Phe Pro  Ala Leu Gln 
    1415                 1420                 1425             


Cys Gln  Asp Phe Ser Gly Ile  Ser Leu Gly Thr Gly  Asp Leu His 
    1430                 1435                 1440             


Ile Phe  His Leu Val Thr Met  Ala His Ile Ile Gln  Ile Leu Leu 
    1445                 1450                 1455             


Thr Ser  Cys Thr Glu Glu Asn  Gly Met Asp Gln Glu  Asn Pro Pro 
    1460                 1465                 1470             


Cys Glu  Glu Glu Ser Ala Val  Leu Ala Leu Tyr Lys  Thr Leu His 
    1475                 1480                 1485             


Gln Tyr  Thr Gly Ser Ala Leu  Lys Glu Ile Pro Ser  Gly Trp His 
    1490                 1495                 1500             


Leu Trp  Arg Ser Val Arg Ala  Gly Ile Met Pro Phe  Leu Lys Cys 
    1505                 1510                 1515             


Ser Ala  Leu Phe Phe His Tyr  Leu Asn Gly Val Pro  Ser Pro Pro 
    1520                 1525                 1530             


Asp Ile  Gln Val Pro Gly Thr  Ser His Phe Glu His  Leu Cys Ser 
    1535                 1540                 1545             


Tyr Leu  Ser Leu Pro Asn Asn  Leu Ile Cys Leu Phe  Gln Glu Asn 
    1550                 1555                 1560             


Ser Glu  Ile Met Asn Ser Leu  Ile Glu Ser Trp Cys  Arg Asn Ser 
    1565                 1570                 1575             


Glu Val  Lys Arg Tyr Leu Glu  Gly Glu Arg Asp Ala  Ile Arg Tyr 
    1580                 1585                 1590             


Pro Arg  Glu Ser Asn Lys Leu  Ile Asn Leu Pro Glu  Asp Tyr Ser 
    1595                 1600                 1605             


Ser Leu  Ile Asn Gln Ala Ser  Asn Phe Ser Cys Pro  Lys Ser Gly 
    1610                 1615                 1620             


Gly Asp  Lys Ser Arg Ala Pro  Thr Leu Cys Leu Val  Cys Gly Ser 
    1625                 1630                 1635             


Leu Leu  Cys Ser Gln Ser Tyr  Cys Cys Gln Thr Glu  Leu Glu Gly 
    1640                 1645                 1650             


Glu Asp  Val Gly Ala Cys Thr  Ala His Thr Tyr Ser  Cys Gly Ser 
    1655                 1660                 1665             


Gly Val  Gly Ile Phe Leu Arg  Val Arg Glu Cys Gln  Val Leu Phe 
    1670                 1675                 1680             


Leu Ala  Gly Lys Thr Lys Gly  Cys Phe Tyr Ser Pro  Pro Tyr Leu 
    1685                 1690                 1695             


Asp Asp  Tyr Gly Glu Thr Asp  Gln Gly Leu Arg Arg  Gly Asn Pro 
    1700                 1705                 1710             


Leu His  Leu Cys Lys Glu Arg  Phe Lys Lys Ile Gln  Lys Leu Trp 
    1715                 1720                 1725             


His Gln  His Ser Val Thr Glu  Glu Ile Gly His Ala  Gln Glu Ala 
    1730                 1735                 1740             


Asn Gln  Thr Leu Val Gly Ile  Asp Trp Gln His Leu  
    1745                 1750                 1755 


<210>  50
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Arg Val Pro Ser Pro Pro Pro Pro Ala Glu Met Ser Ser Gly 
1               5                   10                  15      


Pro Val Ala Glu Ser Trp Cys Tyr Thr Gln Ile Lys Val Val Lys Phe 
            20                  25                  30          


Ser Tyr Met Trp Thr Ile Asn Asn Phe Ser Phe Cys Arg Glu Glu Met 
        35                  40                  45              


Gly Glu Val Ile Lys Ser Ser Thr Phe Ser Ser Gly Ala Asn Asp Lys 
    50                  55                  60                  


Leu Lys Trp Cys Leu Arg Val Asn Pro Lys Gly Leu Asp Glu Glu Ser 
65                  70                  75                  80  


Lys Asp Tyr Leu Ser Leu Tyr Leu Leu Leu Val Ser Cys Pro Lys Ser 
                85                  90                  95      


Glu Val Arg Ala Lys Phe Lys Phe Ser Ile Leu Asn Ala Lys Gly Glu 
            100                 105                 110         


Glu Thr Lys Ala Met Glu Ser Gln Arg Ala Tyr Arg Phe Val Gln Gly 
        115                 120                 125             


Lys Asp Trp Gly Phe Lys Lys Phe Ile Arg Arg Asp Phe Leu Leu Asp 
    130                 135                 140                 


Glu Ala Asn Gly Leu Leu Pro Asp Asp Lys Leu Thr Leu Phe Cys Glu 
145                 150                 155                 160 


Val Ser Val Val Gln Asp Ser Val Asn Ile Ser Gly Gln Asn Thr Met 
                165                 170                 175     


Asn Met Val Lys Val Pro Glu Cys Arg Leu Ala Asp Glu Leu Gly Gly 
            180                 185                 190         


Leu Trp Glu Asn Ser Arg Phe Thr Asp Cys Cys Leu Cys Val Ala Gly 
        195                 200                 205             


Gln Glu Phe Gln Ala His Lys Ala Ile Leu Ala Ala Arg Ser Pro Val 
    210                 215                 220                 


Phe Ser Ala Met Phe Glu His Glu Met Glu Glu Ser Lys Lys Asn Arg 
225                 230                 235                 240 


Val Glu Ile Asn Asp Val Glu Pro Glu Val Phe Lys Glu Met Met Cys 
                245                 250                 255     


Phe Ile Tyr Thr Gly Lys Ala Pro Asn Leu Asp Lys Met Ala Asp Asp 
            260                 265                 270         


Leu Leu Ala Ala Ala Asp Lys Tyr Ala Leu Glu Arg Leu Lys Val Met 
        275                 280                 285             


Cys Glu Asp Ala Leu Cys Ser Asn Leu Ser Val Glu Asn Ala Ala Glu 
    290                 295                 300                 


Ile Leu Ile Leu Ala Asp Leu His Ser Ala Asp Gln Leu Lys Thr Gln 
305                 310                 315                 320 


Ala Val Asp Phe Ile Asn Tyr His Ala Ser Asp Val Leu Glu Thr Ser 
                325                 330                 335     


Gly Trp Lys Ser Met Val Val Ser His Pro His Leu Val Ala Glu Ala 
            340                 345                 350         


Tyr Arg Ser Leu Ala Ser Ala Gln Cys Pro Phe Leu Gly Pro Pro Arg 
        355                 360                 365             


Lys Arg Leu Lys Gln Ser 
    370                 


<210>  51
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Gly Glu Ser Val Lys Leu Ser Ser Gln Thr Leu Ile Gln Ala 
1               5                   10                  15      


Gly Asp Asp Glu Lys Asn Gln Arg Thr Ile Thr Val Asn Pro Ala His 
            20                  25                  30          


Met Gly Lys Ala Phe Lys Val Met Asn Glu Leu Arg Ser Lys Gln Leu 
        35                  40                  45              


Leu Cys Asp Val Met Ile Val Ala Glu Asp Val Glu Ile Glu Ala His 
    50                  55                  60                  


Arg Val Val Leu Ala Ala Cys Ser Pro Tyr Phe Cys Ala Met Phe Thr 
65                  70                  75                  80  


Gly Asp Met Ser Glu Ser Lys Ala Lys Lys Ile Glu Ile Lys Asp Val 
                85                  90                  95      


Asp Gly Gln Thr Leu Ser Lys Leu Ile Asp Tyr Ile Tyr Thr Ala Glu 
            100                 105                 110         


Ile Glu Val Thr Glu Glu Asn Val Gln Val Leu Leu Pro Ala Ala Ser 
        115                 120                 125             


Leu Leu Gln Leu Met Asp Val Arg Gln Asn Cys Cys Asp Phe Leu Gln 
    130                 135                 140                 


Ser Gln Leu His Pro Thr Asn Cys Leu Gly Ile Arg Ala Phe Ala Asp 
145                 150                 155                 160 


Val His Thr Cys Thr Asp Leu Leu Gln Gln Ala Asn Ala Tyr Ala Glu 
                165                 170                 175     


Gln His Phe Pro Glu Val Met Leu Gly Glu Glu Phe Leu Ser Leu Ser 
            180                 185                 190         


Leu Asp Gln Val Cys Ser Leu Ile Ser Ser Asp Lys Leu Thr Val Ser 
        195                 200                 205             


Ser Glu Glu Lys Val Phe Glu Ala Val Ile Ser Trp Ile Asn Tyr Glu 
    210                 215                 220                 


Lys Glu Thr Arg Leu Glu His Met Ala Lys Leu Met Glu His Val Arg 
225                 230                 235                 240 


Leu Pro Leu Leu Pro Arg Asp Tyr Leu Val Gln Thr Val Glu Glu Glu 
                245                 250                 255     


Ala Leu Ile Lys Asn Asn Asn Thr Cys Lys Asp Phe Leu Ile Glu Ala 
            260                 265                 270         


Met Lys Tyr His Leu Leu Pro Leu Asp Gln Arg Leu Leu Ile Lys Asn 
        275                 280                 285             


Pro Arg Thr Lys Pro Arg Thr Pro Val Ser Leu Pro Lys Val Met Ile 
    290                 295                 300                 


Val Val Gly Gly Gln Ala Pro Lys Ala Ile Arg Ser Val Glu Cys Tyr 
305                 310                 315                 320 


Asp Phe Glu Glu Asp Arg Trp Asp Gln Ile Ala Glu Leu Pro Ser Arg 
                325                 330                 335     


Arg Cys Arg Ala Gly Val Val Phe Met Ala Gly His Val Tyr Ala Val 
            340                 345                 350         


Gly Gly Phe Asn Gly Ser Leu Arg Val Arg Thr Val Asp Val Tyr Asp 
        355                 360                 365             


Gly Val Lys Asp Gln Trp Thr Ser Ile Ala Ser Met Gln Glu Arg Arg 
    370                 375                 380                 


Ser Thr Leu Gly Ala Ala Val Leu Asn Asp Leu Leu Tyr Ala Val Gly 
385                 390                 395                 400 


Gly Phe Asp Gly Ser Thr Gly Leu Ala Ser Val Glu Ala Tyr Ser Tyr 
                405                 410                 415     


Lys Thr Asn Glu Trp Phe Phe Val Ala Pro Met Asn Thr Arg Arg Ser 
            420                 425                 430         


Ser Val Gly Val Gly Val Val Glu Gly Lys Leu Tyr Ala Val Gly Gly 
        435                 440                 445             


Tyr Asp Gly Ala Ser Arg Gln Cys Leu Ser Thr Val Glu Gln Tyr Asn 
    450                 455                 460                 


Pro Ala Thr Asn Glu Trp Ile Tyr Val Ala Asp Met Ser Thr Arg Arg 
465                 470                 475                 480 


Ser Gly Ala Gly Val Gly Val Leu Ser Gly Gln Leu Tyr Ala Thr Gly 
                485                 490                 495     


Gly His Asp Gly Pro Leu Val Arg Lys Ser Val Glu Val Tyr Asp Pro 
            500                 505                 510         


Gly Thr Asn Thr Trp Lys Gln Val Ala Asp Met Asn Met Cys Arg Arg 
        515                 520                 525             


Asn Ala Gly Val Cys Ala Val Asn Gly Leu Leu Tyr Val Val Gly Gly 
    530                 535                 540                 


Asp Asp Gly Ser Cys Asn Leu Ala Ser Val Glu Tyr Tyr Asn Pro Val 
545                 550                 555                 560 


Thr Asp Lys Trp Thr Leu Leu Pro Thr Asn Met Ser Thr Gly Arg Ser 
                565                 570                 575     


Tyr Ala Gly Val Ala Val Ile His Lys Ser Leu 
            580                 585         


<210>  52
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Gly Ile Met Ala Pro Lys Asp Ile Met Thr Asn Thr His Ala 
1               5                   10                  15      


Lys Ser Ile Leu Asn Ser Met Asn Ser Leu Arg Lys Ser Asn Thr Leu 
            20                  25                  30          


Cys Asp Val Thr Leu Arg Val Glu Gln Lys Asp Phe Pro Ala His Arg 
        35                  40                  45              


Ile Val Leu Ala Ala Cys Ser Asp Tyr Phe Cys Ala Met Phe Thr Ser 
    50                  55                  60                  


Glu Leu Ser Glu Lys Gly Lys Pro Tyr Val Asp Ile Gln Gly Leu Thr 
65                  70                  75                  80  


Ala Ser Thr Met Glu Ile Leu Leu Asp Phe Val Tyr Thr Glu Thr Val 
                85                  90                  95      


His Val Thr Val Glu Asn Val Gln Glu Leu Leu Pro Ala Ala Cys Leu 
            100                 105                 110         


Leu Gln Leu Lys Gly Val Lys Gln Ala Cys Cys Glu Phe Leu Glu Ser 
        115                 120                 125             


Gln Leu Asp Pro Ser Asn Cys Leu Gly Ile Arg Asp Phe Ala Glu Thr 
    130                 135                 140                 


His Asn Cys Val Asp Leu Met Gln Ala Ala Glu Val Phe Ser Gln Lys 
145                 150                 155                 160 


His Phe Pro Glu Val Val Gln His Glu Glu Phe Ile Leu Leu Ser Gln 
                165                 170                 175     


Gly Glu Val Glu Lys Leu Ile Lys Cys Asp Glu Ile Gln Val Asp Ser 
            180                 185                 190         


Glu Glu Pro Val Phe Glu Ala Val Ile Asn Trp Val Lys His Ala Lys 
        195                 200                 205             


Lys Glu Arg Glu Glu Ser Leu Pro Asn Leu Leu Gln Tyr Val Arg Met 
    210                 215                 220                 


Pro Leu Leu Thr Pro Arg Tyr Ile Thr Asp Val Ile Asp Ala Glu Pro 
225                 230                 235                 240 


Phe Ile Arg Cys Ser Leu Gln Cys Arg Asp Leu Val Asp Glu Ala Lys 
                245                 250                 255     


Lys Phe His Leu Arg Pro Glu Leu Arg Ser Gln Met Gln Gly Pro Arg 
            260                 265                 270         


Thr Arg Ala Arg Leu Gly Ala Asn Glu Val Leu Leu Val Val Gly Gly 
        275                 280                 285             


Phe Gly Ser Gln Gln Ser Pro Ile Asp Val Val Glu Lys Tyr Asp Pro 
    290                 295                 300                 


Lys Thr Gln Glu Trp Ser Phe Leu Pro Ser Ile Thr Arg Lys Arg Arg 
305                 310                 315                 320 


Tyr Val Ala Ser Val Ser Leu His Asp Arg Ile Tyr Val Ile Gly Gly 
                325                 330                 335     


Tyr Asp Gly Arg Ser Arg Leu Ser Ser Val Glu Cys Leu Asp Tyr Thr 
            340                 345                 350         


Ala Asp Glu Asp Gly Val Trp Tyr Ser Val Ala Pro Met Asn Val Arg 
        355                 360                 365             


Arg Gly Leu Ala Gly Ala Thr Thr Leu Gly Asp Met Ile Tyr Val Ser 
    370                 375                 380                 


Gly Gly Phe Asp Gly Ser Arg Arg His Thr Ser Met Glu Arg Tyr Asp 
385                 390                 395                 400 


Pro Asn Ile Asp Gln Trp Ser Met Leu Gly Asp Met Gln Thr Ala Arg 
                405                 410                 415     


Glu Gly Ala Gly Leu Val Val Ala Ser Gly Val Ile Tyr Cys Leu Gly 
            420                 425                 430         


Gly Tyr Asp Gly Leu Asn Ile Leu Asn Ser Val Glu Lys Tyr Asp Pro 
        435                 440                 445             


His Thr Gly His Trp Thr Asn Val Thr Pro Met Ala Thr Lys Arg Ser 
    450                 455                 460                 


Gly Ala Gly Val Ala Leu Leu Asn Asp His Ile Tyr Val Val Gly Gly 
465                 470                 475                 480 


Phe Asp Gly Thr Ala His Leu Ser Ser Val Glu Ala Tyr Asn Ile Arg 
                485                 490                 495     


Thr Asp Ser Trp Thr Thr Val Thr Ser Met Thr Thr Pro Arg Cys Tyr 
            500                 505                 510         


Val Gly Ala Thr Val Leu Arg Gly Arg Leu Tyr Ala Ile Ala Gly Tyr 
        515                 520                 525             


Asp Gly Asn Ser Leu Leu Ser Ser Ile Glu Cys Tyr Asp Pro Ile Ile 
    530                 535                 540                 


Asp Ser Trp Glu Val Val Thr Ser Met Gly Thr Gln Arg Cys Asp Ala 
545                 550                 555                 560 


Gly Val Cys Val Leu Arg Glu Lys 
                565             


<210>  53
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Glu Gly Lys Pro Met Arg Arg Cys Thr Asn Ile Arg Pro Gly Glu 
1               5                   10                  15      


Thr Gly Met Asp Val Thr Ser Arg Cys Thr Leu Gly Asp Pro Asn Lys 
            20                  25                  30          


Leu Pro Glu Gly Val Pro Gln Pro Ala Arg Met Pro Tyr Ile Ser Asp 
        35                  40                  45              


Lys His Pro Arg Gln Thr Leu Glu Val Ile Asn Leu Leu Arg Lys His 
    50                  55                  60                  


Arg Glu Leu Cys Asp Val Val Leu Val Val Gly Ala Lys Lys Ile Tyr 
65                  70                  75                  80  


Ala His Arg Val Ile Leu Ser Ala Cys Ser Pro Tyr Phe Arg Ala Met 
                85                  90                  95      


Phe Thr Gly Glu Leu Ala Glu Ser Arg Gln Thr Glu Val Val Ile Arg 
            100                 105                 110         


Asp Ile Asp Glu Arg Ala Met Glu Leu Leu Ile Asp Phe Ala Tyr Thr 
        115                 120                 125             


Ser Gln Ile Thr Val Glu Glu Gly Asn Val Gln Thr Leu Leu Pro Ala 
    130                 135                 140                 


Ala Cys Leu Leu Gln Leu Ala Glu Ile Gln Glu Ala Cys Cys Glu Phe 
145                 150                 155                 160 


Leu Lys Arg Gln Leu Asp Pro Ser Asn Cys Leu Gly Ile Arg Ala Phe 
                165                 170                 175     


Ala Asp Thr His Ser Cys Arg Glu Leu Leu Arg Ile Ala Asp Lys Phe 
            180                 185                 190         


Thr Gln His Asn Phe Gln Glu Val Met Glu Ser Glu Glu Phe Met Leu 
        195                 200                 205             


Leu Pro Ala Asn Gln Leu Ile Asp Ile Ile Ser Ser Asp Glu Leu Asn 
    210                 215                 220                 


Val Arg Ser Glu Glu Gln Val Phe Asn Ala Val Met Ala Trp Val Lys 
225                 230                 235                 240 


Tyr Ser Ile Gln Glu Arg Arg Pro Gln Leu Pro Gln Val Leu Gln His 
                245                 250                 255     


Val Arg Leu Pro Leu Leu Ser Pro Lys Phe Leu Val Gly Thr Val Gly 
            260                 265                 270         


Ser Asp Pro Leu Ile Lys Ser Asp Glu Glu Cys Arg Asp Leu Val Asp 
        275                 280                 285             


Glu Ala Lys Asn Tyr Leu Leu Leu Pro Gln Glu Arg Pro Leu Met Gln 
    290                 295                 300                 


Gly Pro Arg Thr Arg Pro Arg Lys Pro Ile Arg Cys Gly Glu Val Leu 
305                 310                 315                 320 


Phe Ala Val Gly Gly Trp Cys Ser Gly Asp Ala Ile Ser Ser Val Glu 
                325                 330                 335     


Arg Tyr Asp Pro Gln Thr Asn Glu Trp Arg Met Val Ala Ser Met Ser 
            340                 345                 350         


Lys Arg Arg Cys Gly Val Gly Val Ser Val Leu Asp Asp Leu Leu Tyr 
        355                 360                 365             


Ala Val Gly Gly His Asp Gly Ser Ser Tyr Leu Asn Ser Val Glu Arg 
    370                 375                 380                 


Tyr Asp Pro Lys Thr Asn Gln Trp Ser Ser Asp Val Ala Pro Thr Ser 
385                 390                 395                 400 


Thr Cys Arg Thr Ser Val Gly Val Ala Val Leu Gly Gly Phe Leu Tyr 
                405                 410                 415     


Ala Val Gly Gly Gln Asp Gly Val Ser Cys Leu Asn Ile Val Glu Arg 
            420                 425                 430         


Tyr Asp Pro Lys Glu Asn Lys Trp Thr Arg Val Ala Ser Met Ser Thr 
        435                 440                 445             


Arg Arg Leu Gly Val Ala Val Ala Val Leu Gly Gly Phe Leu Tyr Ala 
    450                 455                 460                 


Val Gly Gly Ser Asp Gly Thr Ser Pro Leu Asn Thr Val Glu Arg Tyr 
465                 470                 475                 480 


Asn Pro Gln Glu Asn Arg Trp His Thr Ile Ala Pro Met Gly Thr Arg 
                485                 490                 495     


Arg Lys His Leu Gly Cys Ala Val Tyr Gln Asp Met Ile Tyr Ala Val 
            500                 505                 510         


Gly Gly Arg Asp Asp Thr Thr Glu Leu Ser Ser Ala Glu Arg Tyr Asn 
        515                 520                 525             


Pro Arg Thr Asn Gln Trp Ser Pro Val Val Ala Met Thr Ser Arg Arg 
    530                 535                 540                 


Ser Gly Val Gly Leu Ala Val Val Asn Gly Gln Leu Met Ala Val Gly 
545                 550                 555                 560 


Gly Phe Asp Gly Thr Thr Tyr Leu Lys Thr Ile Glu Val Phe Asp Pro 
                565                 570                 575     


Asp Ala Asn Thr Trp Arg Leu Tyr Gly Gly Met Asn Tyr Arg Arg Leu 
            580                 585                 590         


Gly Gly Gly Val Gly Val Ile Lys Met Thr His Cys Glu Ser His Ile 
        595                 600                 605             


Trp 
    


<210>  54
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Asp Gly Asn Glu Asp Leu Arg Ala Asp Asp Leu Pro Gly Pro 
1               5                   10                  15      


Ala Phe Glu Ser Tyr Glu Ser Met Glu Leu Ala Cys Pro Ala Glu Arg 
            20                  25                  30          


Ser Gly His Val Ala Val Ser Asp Gly Arg His Met Phe Val Trp Gly 
        35                  40                  45              


Gly Tyr Lys Ser Asn Gln Val Arg Gly Leu Tyr Asp Phe Tyr Leu Pro 
    50                  55                  60                  


Arg Glu Glu Leu Trp Ile Tyr Asn Met Glu Thr Gly Arg Trp Lys Lys 
65                  70                  75                  80  


Ile Asn Thr Glu Gly Asp Val Pro Pro Ser Met Ser Gly Ser Cys Ala 
                85                  90                  95      


Val Cys Val Asp Arg Val Leu Tyr Leu Phe Gly Gly His His Ser Arg 
            100                 105                 110         


Gly Asn Thr Asn Lys Phe Tyr Met Leu Asp Ser Arg Ser Thr Asp Arg 
        115                 120                 125             


Val Leu Gln Trp Glu Arg Ile Asp Cys Gln Gly Ile Pro Pro Ser Ser 
    130                 135                 140                 


Lys Asp Lys Leu Gly Val Trp Val Tyr Lys Asn Lys Leu Ile Phe Phe 
145                 150                 155                 160 


Gly Gly Tyr Gly Tyr Leu Pro Glu Asp Lys Val Leu Gly Thr Phe Glu 
                165                 170                 175     


Phe Asp Glu Thr Ser Phe Trp Asn Ser Ser His Pro Arg Gly Trp Asn 
            180                 185                 190         


Asp His Val His Ile Leu Asp Thr Glu Thr Phe Thr Trp Ser Gln Pro 
        195                 200                 205             


Ile Thr Thr Gly Lys Ala Pro Ser Pro Arg Ala Ala His Ala Cys Ala 
    210                 215                 220                 


Thr Val Gly Asn Arg Gly Phe Val Phe Gly Gly Arg Tyr Arg Asp Ala 
225                 230                 235                 240 


Arg Met Asn Asp Leu His Tyr Leu Asn Leu Asp Thr Trp Glu Trp Asn 
                245                 250                 255     


Glu Leu Ile Pro Gln Gly Ile Cys Pro Val Gly Arg Ser Trp His Ser 
            260                 265                 270         


Leu Thr Pro Val Ser Ser Asp His Leu Phe Leu Phe Gly Gly Phe Thr 
        275                 280                 285             


Thr Asp Lys Gln Pro Leu Ser Asp Ala Trp Thr Tyr Cys Ile Ser Lys 
    290                 295                 300                 


Asn Glu Trp Ile Gln Phe Asn His Pro Tyr Thr Glu Lys Pro Arg Leu 
305                 310                 315                 320 


Trp His Thr Ala Cys Ala Ser Asp Glu Gly Glu Val Ile Val Phe Gly 
                325                 330                 335     


Gly Cys Ala Asn Asn Leu Leu Val His His Arg Ala Ala His Ser Asn 
            340                 345                 350         


Glu Ile Leu Ile Phe Ser Val Gln Pro Lys Ser Leu Val Arg Leu Ser 
        355                 360                 365             


Leu Glu Ala Val Ile Cys Phe Lys Glu Met Leu Ala Asn Ser Trp Asn 
    370                 375                 380                 


Cys Leu Pro Lys His Leu Leu His Ser Val Asn Gln Arg Phe Gly Ser 
385                 390                 395                 400 


Asn Asn Thr Ser Gly Ser 
                405     


<210>  55
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gly Gln Lys Val Thr Gly Gly Ile Lys Thr Val Asp Met Arg Asp 
1               5                   10                  15      


Pro Thr Tyr Arg Pro Leu Lys Gln Glu Leu Gln Gly Leu Asp Tyr Cys 
            20                  25                  30          


Lys Pro Thr Arg Leu Asp Leu Leu Leu Asp Met Pro Pro Val Ser Tyr 
        35                  40                  45              


Asp Val Gln Leu Leu His Ser Trp Asn Asn Asn Asp Arg Ser Leu Asn 
    50                  55                  60                  


Val Phe Val Lys Glu Asp Asp Lys Leu Ile Phe His Arg His Pro Val 
65                  70                  75                  80  


Ala Gln Ser Thr Asp Ala Ile Arg Gly Lys Val Gly Tyr Thr Arg Gly 
                85                  90                  95      


Leu His Val Trp Gln Ile Thr Trp Ala Met Arg Gln Arg Gly Thr His 
            100                 105                 110         


Ala Val Val Gly Val Ala Thr Ala Asp Ala Pro Leu His Ser Val Gly 
        115                 120                 125             


Tyr Thr Thr Leu Val Gly Asn Asn His Glu Ser Trp Gly Trp Asp Leu 
    130                 135                 140                 


Gly Arg Asn Arg Leu Tyr His Asp Gly Lys Asn Gln Pro Ser Lys Thr 
145                 150                 155                 160 


Tyr Pro Ala Phe Leu Glu Pro Asp Glu Thr Phe Ile Val Pro Asp Ser 
                165                 170                 175     


Phe Leu Val Ala Leu Asp Met Asp Asp Gly Thr Leu Ser Phe Ile Val 
            180                 185                 190         


Asp Gly Gln Tyr Met Gly Val Ala Phe Arg Gly Leu Lys Gly Lys Lys 
        195                 200                 205             


Leu Tyr Pro Val Val Ser Ala Val Trp Gly His Cys Glu Ile Arg Met 
    210                 215                 220                 


Arg Tyr Leu Asn Gly Leu Asp Pro Glu Pro Leu Pro Leu Met Asp Leu 
225                 230                 235                 240 


Cys Arg Arg Ser Val Arg Leu Ala Leu Gly Arg Glu Arg Leu Gly Glu 
                245                 250                 255     


Ile His Thr Leu Pro Leu Pro Ala Ser Leu Lys Ala Tyr Leu Leu Tyr 
            260                 265                 270         


Gln 
    


<210>  56
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Gln Thr Ala Leu Ala Gly Gly Ser Ser Ser Thr Pro Thr Pro 
1               5                   10                  15      


Gln Ala Leu Tyr Pro Asp Leu Ser Cys Pro Glu Gly Leu Glu Glu Leu 
            20                  25                  30          


Leu Ser Ala Pro Pro Pro Asp Leu Gly Ala Gln Arg Arg His Gly Trp 
        35                  40                  45              


Asn Pro Lys Asp Cys Ser Glu Asn Ile Glu Val Lys Glu Gly Gly Leu 
    50                  55                  60                  


Tyr Phe Glu Arg Arg Pro Val Ala Gln Ser Thr Asp Gly Ala Arg Gly 
65                  70                  75                  80  


Lys Arg Gly Tyr Ser Arg Gly Leu His Ala Trp Glu Ile Ser Trp Pro 
                85                  90                  95      


Leu Glu Gln Arg Gly Thr His Ala Val Val Gly Val Ala Thr Ala Leu 
            100                 105                 110         


Ala Pro Leu Gln Thr Asp His Tyr Ala Ala Leu Leu Gly Ser Asn Ser 
        115                 120                 125             


Glu Ser Trp Gly Trp Asp Ile Gly Arg Gly Lys Leu Tyr His Gln Ser 
    130                 135                 140                 


Lys Gly Pro Gly Ala Pro Gln Tyr Pro Ala Gly Thr Gln Gly Glu Gln 
145                 150                 155                 160 


Leu Glu Val Pro Glu Arg Leu Leu Val Val Leu Asp Met Glu Glu Gly 
                165                 170                 175     


Thr Leu Gly Tyr Ala Ile Gly Gly Thr Tyr Leu Gly Pro Ala Phe Arg 
            180                 185                 190         


Gly Leu Lys Gly Arg Thr Leu Tyr Pro Ala Val Ser Ala Val Trp Gly 
        195                 200                 205             


Gln Cys Gln Val Arg Ile Arg Tyr Leu Gly Glu Arg Arg Ala Glu Pro 
    210                 215                 220                 


His Ser Leu Leu His Leu Ser Arg Leu Cys Val Arg His Asn Leu Gly 
225                 230                 235                 240 


Asp Thr Arg Leu Gly Gln Val Ser Ala Leu Pro Leu Pro Pro Ala Met 
                245                 250                 255     


Lys Arg Tyr Leu Leu Tyr Gln 
            260             


<210>  57
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gly Gln Lys Leu Ser Gly Ser Leu Lys Ser Val Glu Val Arg Glu 
1               5                   10                  15      


Pro Ala Leu Arg Pro Ala Lys Arg Glu Leu Arg Gly Ala Glu Pro Gly 
            20                  25                  30          


Arg Pro Ala Arg Leu Asp Gln Leu Leu Asp Met Pro Ala Ala Gly Leu 
        35                  40                  45              


Ala Val Gln Leu Arg His Ala Trp Asn Pro Glu Asp Arg Ser Leu Asn 
    50                  55                  60                  


Val Phe Val Lys Asp Asp Asp Arg Leu Thr Phe His Arg His Pro Val 
65                  70                  75                  80  


Ala Gln Ser Thr Asp Gly Ile Arg Gly Lys Val Gly His Ala Arg Gly 
                85                  90                  95      


Leu His Ala Trp Gln Ile Asn Trp Pro Ala Arg Gln Arg Gly Thr His 
            100                 105                 110         


Ala Val Val Gly Val Ala Thr Ala Arg Ala Pro Leu His Ser Val Gly 
        115                 120                 125             


Tyr Thr Ala Leu Val Gly Ser Asp Ala Glu Ser Trp Gly Trp Asp Leu 
    130                 135                 140                 


Gly Arg Ser Arg Leu Tyr His Asp Gly Lys Asn Gln Pro Gly Val Ala 
145                 150                 155                 160 


Tyr Pro Ala Phe Leu Gly Pro Asp Glu Ala Phe Ala Leu Pro Asp Ser 
                165                 170                 175     


Leu Leu Val Val Leu Asp Met Asp Glu Gly Thr Leu Ser Phe Ile Val 
            180                 185                 190         


Asp Gly Gln Tyr Leu Gly Val Ala Phe Arg Gly Leu Lys Gly Lys Lys 
        195                 200                 205             


Leu Tyr Pro Val Val Ser Ala Val Trp Gly His Cys Glu Val Thr Met 
    210                 215                 220                 


Arg Tyr Ile Asn Gly Leu Asp Pro Glu Pro Leu Pro Leu Met Asp Leu 
225                 230                 235                 240 


Cys Arg Arg Ser Ile Arg Ser Ala Leu Gly Arg Gln Arg Leu Gln Asp 
                245                 250                 255     


Ile Ser Ser Leu Pro Leu Pro Gln Ser Leu Lys Asn Tyr Leu Gln Tyr 
            260                 265                 270         


Gln 
    


<210>  58
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Thr Leu Arg Cys Leu Glu Pro Ser Gly Asn Gly Gly Glu Gly Thr 
1               5                   10                  15      


Arg Ser Gln Trp Gly Thr Ala Gly Ser Ala Glu Glu Pro Ser Pro Gln 
            20                  25                  30          


Ala Ala Arg Leu Ala Lys Ala Leu Arg Glu Leu Gly Gln Thr Gly Trp 
        35                  40                  45              


Tyr Trp Gly Ser Met Thr Val Asn Glu Ala Lys Glu Lys Leu Lys Glu 
    50                  55                  60                  


Ala Pro Glu Gly Thr Phe Leu Ile Arg Asp Ser Ser His Ser Asp Tyr 
65                  70                  75                  80  


Leu Leu Thr Ile Ser Val Lys Thr Ser Ala Gly Pro Thr Asn Leu Arg 
                85                  90                  95      


Ile Glu Tyr Gln Asp Gly Lys Phe Arg Leu Asp Ser Ile Ile Cys Val 
            100                 105                 110         


Lys Ser Lys Leu Lys Gln Phe Asp Ser Val Val His Leu Ile Asp Tyr 
        115                 120                 125             


Tyr Val Gln Met Cys Lys Asp Lys Arg Thr Gly Pro Glu Ala Pro Arg 
    130                 135                 140                 


Asn Gly Thr Val His Leu Tyr Leu Thr Lys Pro Leu Tyr Thr Ser Ala 
145                 150                 155                 160 


Pro Ser Leu Gln His Leu Cys Arg Leu Thr Ile Asn Lys Cys Thr Gly 
                165                 170                 175     


Ala Ile Trp Gly Leu Pro Leu Pro Thr Arg Leu Lys Asp Tyr Leu Glu 
            180                 185                 190         


Glu Tyr Lys Phe Gln Val 
        195             


<210>  59
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Lys Lys Ile Ser Leu Lys Thr Leu Arg Lys Ser Phe Asn Leu Asn 
1               5                   10                  15      


Lys Ser Lys Glu Glu Thr Asp Phe Met Val Val Gln Gln Pro Ser Leu 
            20                  25                  30          


Ala Ser Asp Phe Gly Lys Asp Asp Ser Leu Phe Gly Ser Cys Tyr Gly 
        35                  40                  45              


Lys Asp Met Ala Ser Cys Asp Ile Asn Gly Glu Asp Glu Lys Gly Gly 
    50                  55                  60                  


Lys Asn Arg Ser Lys Ser Glu Ser Leu Met Gly Thr Leu Lys Arg Arg 
65                  70                  75                  80  


Leu Ser Ala Lys Gln Lys Ser Lys Gly Lys Ala Gly Thr Pro Ser Gly 
                85                  90                  95      


Ser Ser Ala Asp Glu Asp Thr Phe Ser Ser Ser Ser Ala Pro Ile Val 
            100                 105                 110         


Phe Lys Asp Val Arg Ala Gln Arg Pro Ile Arg Ser Thr Ser Leu Arg 
        115                 120                 125             


Ser His His Tyr Ser Pro Ala Pro Trp Pro Leu Arg Pro Thr Asn Ser 
    130                 135                 140                 


Glu Glu Thr Cys Ile Lys Met Glu Val Arg Val Lys Ala Leu Val His 
145                 150                 155                 160 


Ser Ser Ser Pro Ser Pro Ala Leu Asn Gly Val Arg Lys Asp Phe His 
                165                 170                 175     


Asp Leu Gln Ser Glu Thr Thr Cys Gln Glu Gln Ala Asn Ser Leu Lys 
            180                 185                 190         


Ser Ser Ala Ser His Asn Gly Asp Leu His Leu His Leu Asp Glu His 
        195                 200                 205             


Val Pro Val Val Ile Gly Leu Met Pro Gln Asp Tyr Ile Gln Tyr Thr 
    210                 215                 220                 


Val Pro Leu Asp Glu Gly Met Tyr Pro Leu Glu Gly Ser Arg Ser Tyr 
225                 230                 235                 240 


Cys Leu Asp Ser Ser Ser Pro Met Glu Val Ser Ala Val Pro Pro Gln 
                245                 250                 255     


Val Gly Gly Arg Ala Phe Pro Glu Asp Glu Ser Gln Val Asp Gln Asp 
            260                 265                 270         


Leu Val Val Ala Pro Glu Ile Phe Val Asp Gln Ser Val Asn Gly Leu 
        275                 280                 285             


Leu Ile Gly Thr Thr Gly Val Met Leu Gln Ser Pro Arg Ala Gly His 
    290                 295                 300                 


Asp Asp Val Pro Pro Leu Ser Pro Leu Leu Pro Pro Met Gln Asn Asn 
305                 310                 315                 320 


Gln Ile Gln Arg Asn Phe Ser Gly Leu Thr Gly Thr Glu Ala His Val 
                325                 330                 335     


Ala Glu Ser Met Arg Cys His Leu Asn Phe Asp Pro Asn Ser Ala Pro 
            340                 345                 350         


Gly Val Ala Arg Val Tyr Asp Ser Val Gln Ser Ser Gly Pro Met Val 
        355                 360                 365             


Val Thr Ser Leu Thr Glu Glu Leu Lys Lys Leu Ala Lys Gln Gly Trp 
    370                 375                 380                 


Tyr Trp Gly Pro Ile Thr Arg Trp Glu Ala Glu Gly Lys Leu Ala Asn 
385                 390                 395                 400 


Val Pro Asp Gly Ser Phe Leu Val Arg Asp Ser Ser Asp Asp Arg Tyr 
                405                 410                 415     


Leu Leu Ser Leu Ser Phe Arg Ser His Gly Lys Thr Leu His Thr Arg 
            420                 425                 430         


Ile Glu His Ser Asn Gly Arg Phe Ser Phe Tyr Glu Gln Pro Asp Val 
        435                 440                 445             


Glu Gly His Thr Ser Ile Val Asp Leu Ile Glu His Ser Ile Arg Asp 
    450                 455                 460                 


Ser Glu Asn Gly Ala Phe Cys Tyr Ser Arg Ser Arg Leu Pro Gly Ser 
465                 470                 475                 480 


Ala Thr Tyr Pro Val Arg Leu Thr Asn Pro Val Ser Arg Phe Met Gln 
                485                 490                 495     


Val Arg Ser Leu Gln Tyr Leu Cys Arg Phe Val Ile Arg Gln Tyr Thr 
            500                 505                 510         


Arg Ile Asp Leu Ile Gln Lys Leu Pro Leu Pro Asn Lys Met Lys Asp 
        515                 520                 525             


Tyr Leu Gln Glu Lys His Tyr 
    530                 535 


<210>  60
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Gly Ser Glu Pro Arg Ser Gly Thr Asn Ser Pro Pro Pro Pro 
1               5                   10                  15      


Phe Ser Asp Trp Gly Arg Leu Glu Ala Ala Ile Leu Ser Gly Trp Lys 
            20                  25                  30          


Thr Phe Trp Gln Ser Val Ser Lys Glu Arg Val Ala Arg Thr Thr Ser 
        35                  40                  45              


Arg Glu Glu Val Asp Glu Ala Ala Ser Thr Leu Thr Arg Leu Pro Ile 
    50                  55                  60                  


Asp Val Gln Leu Tyr Ile Leu Ser Phe Leu Ser Pro His Asp Leu Cys 
65                  70                  75                  80  


Gln Leu Gly Ser Thr Asn His Tyr Trp Asn Glu Thr Val Arg Asp Pro 
                85                  90                  95      


Ile Leu Trp Arg Tyr Phe Leu Leu Arg Asp Leu Pro Ser Trp Ser Ser 
            100                 105                 110         


Val Asp Trp Lys Ser Leu Pro Asp Leu Glu Ile Leu Lys Lys Pro Ile 
        115                 120                 125             


Ser Glu Val Thr Asp Gly Ala Phe Phe Asp Tyr Met Ala Val Tyr Arg 
    130                 135                 140                 


Met Cys Cys Pro Tyr Thr Arg Arg Ala Ser Lys Ser Ser Arg Pro Met 
145                 150                 155                 160 


Tyr Gly Ala Val Thr Ser Phe Leu His Ser Leu Ile Ile Gln Asn Glu 
                165                 170                 175     


Pro Arg Phe Ala Met Phe Gly Pro Gly Leu Glu Glu Leu Asn Thr Ser 
            180                 185                 190         


Leu Val Leu Ser Leu Met Ser Ser Glu Glu Leu Cys Pro Thr Ala Gly 
        195                 200                 205             


Leu Pro Gln Arg Gln Ile Asp Gly Ile Gly Ser Gly Val Asn Phe Gln 
    210                 215                 220                 


Leu Asn Asn Gln His Lys Phe Asn Ile Leu Ile Leu Tyr Ser Thr Thr 
225                 230                 235                 240 


Arg Lys Glu Arg Asp Arg Ala Arg Glu Glu His Thr Ser Ala Val Asn 
                245                 250                 255     


Lys Met Phe Ser Arg His Asn Glu Gly Asp Asp Gln Gln Gly Ser Arg 
            260                 265                 270         


Tyr Ser Val Ile Pro Gln Ile Gln Lys Val Cys Glu Val Val Asp Gly 
        275                 280                 285             


Phe Ile Tyr Val Ala Asn Ala Glu Ala His Lys Arg His Glu Trp Gln 
    290                 295                 300                 


Asp Glu Phe Ser His Ile Met Ala Met Thr Asp Pro Ala Phe Gly Ser 
305                 310                 315                 320 


Ser Gly Arg Pro Leu Leu Val Leu Ser Cys Ile Ser Gln Gly Asp Val 
                325                 330                 335     


Lys Arg Met Pro Cys Phe Tyr Leu Ala His Glu Leu His Leu Asn Leu 
            340                 345                 350         


Leu Asn His Pro Trp Leu Val Gln Asp Thr Glu Ala Glu Thr Leu Thr 
        355                 360                 365             


Gly Phe Leu Asn Gly Ile Glu Trp Ile Leu Glu Glu Val Glu Ser Lys 
    370                 375                 380                 


Arg Ala Arg 
385         


<210>  61
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Val Cys Ala Arg Leu Cys Gly Val Gly Pro Ser Arg Gly Cys 
1               5                   10                  15      


Arg Arg Arg Gln Gln Arg Arg Gly Pro Ala Glu Thr Ala Ala Ala Asp 
            20                  25                  30          


Ser Glu Pro Asp Thr Asp Pro Glu Glu Glu Arg Ile Glu Ala Ser Ala 
        35                  40                  45              


Gly Val Gly Gly Gly Leu Cys Ala Gly Pro Ser Pro Pro Pro Pro Arg 
    50                  55                  60                  


Cys Ser Leu Leu Glu Leu Pro Pro Glu Leu Leu Val Glu Ile Phe Ala 
65                  70                  75                  80  


Ser Leu Pro Gly Thr Asp Leu Pro Ser Leu Ala Gln Val Cys Thr Lys 
                85                  90                  95      


Phe Arg Arg Ile Leu His Thr Asp Thr Ile Trp Arg Arg Arg Cys Arg 
            100                 105                 110         


Glu Glu Tyr Gly Val Cys Glu Asn Leu Arg Lys Leu Glu Ile Thr Gly 
        115                 120                 125             


Val Ser Cys Arg Asp Val Tyr Ala Lys Leu Leu His Arg Tyr Arg His 
    130                 135                 140                 


Ile Leu Gly Leu Trp Gln Pro Asp Ile Gly Pro Tyr Gly Gly Leu Leu 
145                 150                 155                 160 


Asn Val Val Val Asp Gly Leu Phe Ile Ile Gly Trp Met Tyr Leu Pro 
                165                 170                 175     


Pro His Asp Pro His Val Asp Asp Pro Met Arg Phe Lys Pro Leu Phe 
            180                 185                 190         


Arg Ile His Leu Met Glu Arg Lys Ala Ala Thr Val Glu Cys Met Tyr 
        195                 200                 205             


Gly His Lys Gly Pro His His Gly His Ile Gln Ile Val Lys Lys Asp 
    210                 215                 220                 


Glu Phe Ser Thr Lys Cys Asn Gln Thr Asp His His Arg Met Ser Gly 
225                 230                 235                 240 


Gly Arg Gln Glu Glu Phe Arg Thr Trp Leu Arg Glu Glu Trp Gly Arg 
                245                 250                 255     


Thr Leu Glu Asp Ile Phe His Glu His Met Gln Glu Leu Ile Leu Met 
            260                 265                 270         


Lys Phe Ile Tyr Thr Ser Gln Tyr Asp Asn Cys Leu Thr Tyr Arg Arg 
        275                 280                 285             


Ile Tyr Leu Pro Pro Ser Arg Pro Asp Asp Leu Ile Lys Pro Gly Leu 
    290                 295                 300                 


Phe Lys Gly Thr Tyr Gly Ser His Gly Leu Glu Ile Val Met Leu Ser 
305                 310                 315                 320 


Phe His Gly Arg Arg Ala Arg Gly Thr Lys Ile Thr Gly Asp Pro Asn 
                325                 330                 335     


Ile Pro Ala Gly Gln Gln Thr Val Glu Ile Asp Leu Arg His Arg Ile 
            340                 345                 350         


Gln Leu Pro Asp Leu Glu Asn Gln Arg Asn Phe Asn Glu Leu Ser Arg 
        355                 360                 365             


Ile Val Leu Glu Val Arg Glu Arg Val Arg Gln Glu Gln Gln Glu Gly 
    370                 375                 380                 


Gly His Glu Ala Gly Glu Gly Arg Gly Arg Gln Gly Pro Arg Glu Ser 
385                 390                 395                 400 


Gln Pro Ser Pro Ala Gln Pro Arg Ala Glu Ala Pro Ser Lys Gly Pro 
                405                 410                 415     


Asp Gly Thr Pro Gly Glu Asp Gly Gly Glu Pro Gly Asp Ala Val Ala 
            420                 425                 430         


Ala Ala Glu Gln Pro Ala Gln Cys Gly Gln Gly Gln Pro Phe Val Leu 
        435                 440                 445             


Pro Val Gly Val Ser Ser Arg Asn Glu Asp Tyr Pro Arg Thr Cys Arg 
    450                 455                 460                 


Met Cys Phe Tyr Gly Thr Gly Leu Ile Ala Gly His Gly Phe Thr Ser 
465                 470                 475                 480 


Pro Glu Arg Thr Pro Gly Val Phe Ile Leu Phe Asp Glu Asp Arg Phe 
                485                 490                 495     


Gly Phe Val Trp Leu Glu Leu Lys Ser Phe Ser Leu Tyr Ser Arg Val 
            500                 505                 510         


Gln Ala Thr Phe Arg Asn Ala Asp Ala Pro Ser Pro Gln Ala Phe Asp 
        515                 520                 525             


Glu Met Leu Lys Asn Ile Gln Ser Leu Thr Ser 
    530                 535                 


<210>  62
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Asp Pro Ala Glu Ala Val Leu Gln Glu Lys Ala Leu Lys Phe Met 
1               5                   10                  15      


Cys Ser Met Pro Arg Ser Leu Trp Leu Gly Cys Ser Ser Leu Ala Asp 
            20                  25                  30          


Ser Met Pro Ser Leu Arg Cys Leu Tyr Asn Pro Gly Thr Gly Ala Leu 
        35                  40                  45              


Thr Ala Phe Gln Asn Ser Ser Glu Arg Glu Asp Cys Asn Asn Gly Glu 
    50                  55                  60                  


Pro Pro Arg Lys Ile Ile Pro Glu Lys Asn Ser Leu Arg Gln Thr Tyr 
65                  70                  75                  80  


Asn Ser Cys Ala Arg Leu Cys Leu Asn Gln Glu Thr Val Cys Leu Ala 
                85                  90                  95      


Ser Thr Ala Met Lys Thr Glu Asn Cys Val Ala Lys Thr Lys Leu Ala 
            100                 105                 110         


Asn Gly Thr Ser Ser Met Ile Val Pro Lys Gln Arg Lys Leu Ser Ala 
        115                 120                 125             


Ser Tyr Glu Lys Glu Lys Glu Leu Cys Val Lys Tyr Phe Glu Gln Trp 
    130                 135                 140                 


Ser Glu Ser Asp Gln Val Glu Phe Val Glu His Leu Ile Ser Gln Met 
145                 150                 155                 160 


Cys His Tyr Gln His Gly His Ile Asn Ser Tyr Leu Lys Pro Met Leu 
                165                 170                 175     


Gln Arg Asp Phe Ile Thr Ala Leu Pro Ala Arg Gly Leu Asp His Ile 
            180                 185                 190         


Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala Lys Ser Leu Cys Ala Ala 
        195                 200                 205             


Glu Leu Val Cys Lys Glu Trp Tyr Arg Val Thr Ser Asp Gly Met Leu 
    210                 215                 220                 


Trp Lys Lys Leu Ile Glu Arg Met Val Arg Thr Asp Ser Leu Trp Arg 
225                 230                 235                 240 


Gly Leu Ala Glu Arg Arg Gly Trp Gly Gln Tyr Leu Phe Lys Asn Lys 
                245                 250                 255     


Pro Pro Asp Gly Asn Ala Pro Pro Asn Ser Phe Tyr Arg Ala Leu Tyr 
            260                 265                 270         


Pro Lys Ile Ile Gln Asp Ile Glu Thr Ile Glu Ser Asn Trp Arg Cys 
        275                 280                 285             


Gly Arg His Ser Leu Gln Arg Ile His Cys Arg Ser Glu Thr Ser Lys 
    290                 295                 300                 


Gly Val Tyr Cys Leu Gln Tyr Asp Asp Gln Lys Ile Val Ser Gly Leu 
305                 310                 315                 320 


Arg Asp Asn Thr Ile Lys Ile Trp Asp Lys Asn Thr Leu Glu Cys Lys 
                325                 330                 335     


Arg Ile Leu Thr Gly His Thr Gly Ser Val Leu Cys Leu Gln Tyr Asp 
            340                 345                 350         


Glu Arg Val Ile Ile Thr Gly Ser Ser Asp Ser Thr Val Arg Val Trp 
        355                 360                 365             


Asp Val Asn Thr Gly Glu Met Leu Asn Thr Leu Ile His His Cys Glu 
    370                 375                 380                 


Ala Val Leu His Leu Arg Phe Asn Asn Gly Met Met Val Thr Cys Ser 
385                 390                 395                 400 


Lys Asp Arg Ser Ile Ala Val Trp Asp Met Ala Ser Pro Thr Asp Ile 
                405                 410                 415     


Thr Leu Arg Arg Val Leu Val Gly His Arg Ala Ala Val Asn Val Val 
            420                 425                 430         


Asp Phe Asp Asp Lys Tyr Ile Val Ser Ala Ser Gly Asp Arg Thr Ile 
        435                 440                 445             


Lys Val Trp Asn Thr Ser Thr Cys Glu Phe Val Arg Thr Leu Asn Gly 
    450                 455                 460                 


His Lys Arg Gly Ile Ala Cys Leu Gln Tyr Arg Asp Arg Leu Val Val 
465                 470                 475                 480 


Ser Gly Ser Ser Asp Asn Thr Ile Arg Leu Trp Asp Ile Glu Cys Gly 
                485                 490                 495     


Ala Cys Leu Arg Val Leu Glu Gly His Glu Glu Leu Val Arg Cys Ile 
            500                 505                 510         


Arg Phe Asp Asn Lys Arg Ile Val Ser Gly Ala Tyr Asp Gly Lys Ile 
        515                 520                 525             


Lys Val Trp Asp Leu Val Ala Ala Leu Asp Pro Arg Ala Pro Ala Gly 
    530                 535                 540                 


Thr Leu Cys Leu Arg Thr Leu Val Glu His Ser Gly Arg Val Phe Arg 
545                 550                 555                 560 


Leu Gln Phe Asp Glu Phe Gln Ile Val Ser Ser Ser His Asp Asp Thr 
                565                 570                 575     


Ile Leu Ile Trp Asp Phe Leu Asn Asp Pro Ala Ala Gln Ala Glu Pro 
            580                 585                 590         


Pro Arg Ser Pro Ser Arg Thr Tyr Thr Tyr Ile Ser Arg 
        595                 600                 605 


<210>  63
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  64
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Gln Phe Ala Phe Glu Ser Asp Leu His Ser Leu Leu Gln Leu 
1               5                   10                  15      


Asp Ala Pro Ile Pro Asn Ala Pro Pro Ala Arg Trp Gln Arg Lys Ala 
            20                  25                  30          


Lys Glu Ala Ala Gly Pro Ala Pro Ser Pro Met Arg Ala Ala Asn Arg 
        35                  40                  45              


Ser His Ser Ala Gly Arg Thr Pro Gly Arg Thr Pro Gly Lys Ser Ser 
    50                  55                  60                  


Ser Lys Val Gln Thr Thr Pro Ser Lys Pro Gly Gly Asp Arg Tyr Ile 
65                  70                  75                  80  


Pro His Arg Ser Ala Ala Gln Met Glu Val Ala Ser Phe Leu Leu Ser 
                85                  90                  95      


Lys Glu Asn Gln Pro Glu Asn Ser Gln Thr Pro Thr Lys Lys Glu His 
            100                 105                 110         


Gln Lys Ala Trp Ala Leu Asn Leu Asn Gly Phe Asp Val Glu Glu Ala 
        115                 120                 125             


Lys Ile Leu Arg Leu Ser Gly Lys Pro Gln Asn Ala Pro Glu Gly Tyr 
    130                 135                 140                 


Gln Asn Arg Leu Lys Val Leu Tyr Ser Gln Lys Ala Thr Pro Gly Ser 
145                 150                 155                 160 


Ser Arg Lys Thr Cys Arg Tyr Ile Pro Ser Leu Pro Asp Arg Ile Leu 
                165                 170                 175     


Asp Ala Pro Glu Ile Arg Asn Asp Tyr Tyr Leu Asn Leu Val Asp Trp 
            180                 185                 190         


Ser Ser Gly Asn Val Leu Ala Val Ala Leu Asp Asn Ser Val Tyr Leu 
        195                 200                 205             


Trp Ser Ala Ser Ser Gly Asp Ile Leu Gln Leu Leu Gln Met Glu Gln 
    210                 215                 220                 


Pro Gly Glu Tyr Ile Ser Ser Val Ala Trp Ile Lys Glu Gly Asn Tyr 
225                 230                 235                 240 


Leu Ala Val Gly Thr Ser Ser Ala Glu Val Gln Leu Trp Asp Val Gln 
                245                 250                 255     


Gln Gln Lys Arg Leu Arg Asn Met Thr Ser His Ser Ala Arg Val Gly 
            260                 265                 270         


Ser Leu Ser Trp Asn Ser Tyr Ile Leu Ser Ser Gly Ser Arg Ser Gly 
        275                 280                 285             


His Ile His His His Asp Val Arg Val Ala Glu His His Val Ala Thr 
    290                 295                 300                 


Leu Ser Gly His Ser Gln Glu Val Cys Gly Leu Arg Trp Ala Pro Asp 
305                 310                 315                 320 


Gly Arg His Leu Ala Ser Gly Gly Asn Asp Asn Leu Val Asn Val Trp 
                325                 330                 335     


Pro Ser Ala Pro Gly Glu Gly Gly Trp Val Pro Leu Gln Thr Phe Thr 
            340                 345                 350         


Gln His Gln Gly Ala Val Lys Ala Val Ala Trp Cys Pro Trp Gln Ser 
        355                 360                 365             


Asn Val Leu Ala Thr Gly Gly Gly Thr Ser Asp Arg His Ile Arg Ile 
    370                 375                 380                 


Trp Asn Val Cys Ser Gly Ala Cys Leu Ser Ala Val Asp Ala His Ser 
385                 390                 395                 400 


Gln Val Cys Ser Ile Leu Trp Ser Pro His Tyr Lys Glu Leu Ile Ser 
                405                 410                 415     


Gly His Gly Phe Ala Gln Asn Gln Leu Val Ile Trp Lys Tyr Pro Thr 
            420                 425                 430         


Met Ala Lys Val Ala Glu Leu Lys Gly His Thr Ser Arg Val Leu Ser 
        435                 440                 445             


Leu Thr Met Ser Pro Asp Gly Ala Thr Val Ala Ser Ala Ala Ala Asp 
    450                 455                 460                 


Glu Thr Leu Arg Leu Trp Arg Cys Phe Glu Leu Asp Pro Ala Arg Arg 
465                 470                 475                 480 


Arg Glu Arg Glu Lys Ala Ser Ala Ala Lys Ser Ser Leu Ile His Gln 
                485                 490                 495     


Gly Ile Arg 
            


<210>  65
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ser Asp Ser Gly Ser Gln Leu Gly Ser Met Gly Ser Leu Thr Met 
1               5                   10                  15      


Lys Ser Gln Leu Gln Ile Thr Val Ile Ser Ala Lys Leu Lys Glu Asn 
            20                  25                  30          


Lys Lys Asn Trp Phe Gly Pro Ser Pro Tyr Val Glu Val Thr Val Asp 
        35                  40                  45              


Gly Gln Ser Lys Lys Thr Glu Lys Cys Asn Asn Thr Asn Ser Pro Lys 
    50                  55                  60                  


Trp Lys Gln Pro Leu Thr Val Ile Val Thr Pro Val Ser Lys Leu His 
65                  70                  75                  80  


Phe Arg Val Trp Ser His Gln Thr Leu Lys Ser Asp Val Leu Leu Gly 
                85                  90                  95      


Thr Ala Ala Leu Asp Ile Tyr Glu Thr Leu Lys Ser Asn Asn Met Lys 
            100                 105                 110         


Leu Glu Glu Val Val Val Thr Leu Gln Leu Gly Gly Asp Lys Glu Pro 
        115                 120                 125             


Thr Glu Thr Ile Gly Asp Leu Ser Ile Cys Leu Asp Gly Leu Gln Leu 
    130                 135                 140                 


Glu Ser Glu Val Val Thr Asn Gly Glu Thr Thr Cys Ser Glu Asn Gly 
145                 150                 155                 160 


Val Ser Leu Cys Leu Pro Arg Leu Glu Cys Asn Ser Ala Ile Ser Ala 
                165                 170                 175     


His Cys Asn Leu Cys Leu Pro Gly Leu Ser Asp Ser Pro Ile Ser Ala 
            180                 185                 190         


Ser Arg Val Ala Gly Phe Thr Gly Ala Ser Gln Asn Asp Asp Gly Ser 
        195                 200                 205             


Arg Ser Lys Asp Glu Thr Arg Val Ser Thr Asn Gly Ser Asp Asp Pro 
    210                 215                 220                 


Glu Asp Ala Gly Ala Gly Glu Asn Arg Arg Val Ser Gly Asn Asn Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asn Gly Gly Phe Lys Pro Ser Arg Pro Pro Arg Pro 
                245                 250                 255     


Ser Arg Pro Pro Pro Pro Thr Pro Arg Arg Pro Ala Ser Val Asn Gly 
            260                 265                 270         


Ser Pro Ser Ala Thr Ser Glu Ser Asp Gly Ser Ser Thr Gly Ser Leu 
        275                 280                 285             


Pro Pro Thr Asn Thr Asn Thr Asn Thr Ser Glu Gly Ala Thr Ser Gly 
    290                 295                 300                 


Leu Ile Ile Pro Leu Thr Ile Ser Gly Gly Ser Gly Pro Arg Pro Leu 
305                 310                 315                 320 


Asn Pro Val Thr Gln Ala Pro Leu Pro Pro Gly Trp Glu Gln Arg Val 
                325                 330                 335     


Asp Gln His Gly Arg Val Tyr Tyr Val Asp His Val Glu Lys Arg Thr 
            340                 345                 350         


Thr Trp Asp Arg Pro Glu Pro Leu Pro Pro Gly Trp Glu Arg Arg Val 
        355                 360                 365             


Asp Asn Met Gly Arg Ile Tyr Tyr Val Asp His Phe Thr Arg Thr Thr 
    370                 375                 380                 


Thr Trp Gln Arg Pro Thr Leu Glu Ser Val Arg Asn Tyr Glu Gln Trp 
385                 390                 395                 400 


Gln Leu Gln Arg Ser Gln Leu Gln Gly Ala Met Gln Gln Phe Asn Gln 
                405                 410                 415     


Arg Phe Ile Tyr Gly Asn Gln Asp Leu Phe Ala Thr Ser Gln Ser Lys 
            420                 425                 430         


Glu Phe Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr 
        435                 440                 445             


Asp Ser Asn Gly Arg Val Tyr Phe Val Asn His Asn Thr Arg Ile Thr 
    450                 455                 460                 


Gln Trp Glu Asp Pro Arg Ser Gln Gly Gln Leu Asn Glu Lys Pro Leu 
465                 470                 475                 480 


Pro Glu Gly Trp Glu Met Arg Phe Thr Val Asp Gly Ile Pro Tyr Phe 
                485                 490                 495     


Val Asp His Asn Arg Arg Thr Thr Thr Tyr Ile Asp Pro Arg Thr Gly 
            500                 505                 510         


Lys Ser Ala Leu Asp Asn Gly Pro Gln Ile Ala Tyr Val Arg Asp Phe 
        515                 520                 525             


Lys Ala Lys Val Gln Tyr Phe Arg Phe Trp Cys Gln Gln Leu Ala Met 
    530                 535                 540                 


Pro Gln His Ile Lys Ile Thr Val Thr Arg Lys Thr Leu Phe Glu Asp 
545                 550                 555                 560 


Ser Phe Gln Gln Ile Met Ser Phe Ser Pro Gln Asp Leu Arg Arg Arg 
                565                 570                 575     


Leu Trp Val Ile Phe Pro Gly Glu Glu Gly Leu Asp Tyr Gly Gly Val 
            580                 585                 590         


Ala Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met 
        595                 600                 605             


Tyr Cys Leu Phe Glu Tyr Ala Gly Lys Asp Asn Tyr Cys Leu Gln Ile 
    610                 615                 620                 


Asn Pro Ala Ser Tyr Ile Asn Pro Asp His Leu Lys Tyr Phe Arg Phe 
625                 630                 635                 640 


Ile Gly Arg Phe Ile Ala Met Ala Leu Phe His Gly Lys Phe Ile Asp 
                645                 650                 655     


Thr Gly Phe Ser Leu Pro Phe Tyr Lys Arg Ile Leu Asn Lys Pro Val 
            660                 665                 670         


Gly Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Leu 
        675                 680                 685             


Ile Trp Val Lys Glu Asn Asn Ile Glu Glu Cys Asp Leu Glu Met Tyr 
    690                 695                 700                 


Phe Ser Val Asp Lys Glu Ile Leu Gly Glu Ile Lys Ser His Asp Leu 
705                 710                 715                 720 


Lys Pro Asn Gly Gly Asn Ile Leu Val Thr Glu Glu Asn Lys Glu Glu 
                725                 730                 735     


Tyr Ile Arg Met Val Ala Glu Trp Arg Leu Ser Arg Gly Val Glu Glu 
            740                 745                 750         


Gln Thr Gln Ala Phe Phe Glu Gly Phe Asn Glu Ile Leu Pro Gln Gln 
        755                 760                 765             


Tyr Leu Gln Tyr Phe Asp Ala Lys Glu Leu Glu Val Leu Leu Cys Gly 
    770                 775                 780                 


Met Gln Glu Ile Asp Leu Asn Asp Trp Gln Arg His Ala Ile Tyr Arg 
785                 790                 795                 800 


His Tyr Ala Arg Thr Ser Lys Gln Ile Met Trp Phe Trp Gln Phe Val 
                805                 810                 815     


Lys Glu Ile Asp Asn Glu Lys Arg Met Arg Leu Leu Gln Phe Val Thr 
            820                 825                 830         


Gly Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Asp Leu Met Gly Ser 
        835                 840                 845             


Asn Gly Pro Gln Lys Phe Cys Ile Glu Lys Val Gly Lys Glu Asn Trp 
    850                 855                 860                 


Leu Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr 
865                 870                 875                 880 


Lys Ser Tyr Glu Gln Leu Lys Glu Lys Leu Leu Phe Ala Ile Glu Glu 
                885                 890                 895     


Thr Glu Gly Phe Gly Gln Glu 
            900             


<210>  66
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Glu Pro Ala Pro Ala Arg Ser Pro Arg Pro Gln Gln Asp Pro Ala 
1               5                   10                  15      


Arg Pro Gln Glu Pro Thr Met Pro Pro Pro Glu Thr Pro Ser Glu Gly 
            20                  25                  30          


Arg Gln Pro Ser Pro Ser Pro Ser Pro Thr Glu Arg Ala Pro Ala Ser 
        35                  40                  45              


Glu Glu Glu Phe Gln Phe Leu Arg Cys Gln Gln Cys Gln Ala Glu Ala 
    50                  55                  60                  


Lys Cys Pro Lys Leu Leu Pro Cys Leu His Thr Leu Cys Ser Gly Cys 
65                  70                  75                  80  


Leu Glu Ala Ser Gly Met Gln Cys Pro Ile Cys Gln Ala Pro Trp Pro 
                85                  90                  95      


Leu Gly Ala Asp Thr Pro Ala Leu Asp Asn Val Phe Phe Glu Ser Leu 
            100                 105                 110         


Gln Arg Arg Leu Ser Val Tyr Arg Gln Ile Val Asp Ala Gln Ala Val 
        115                 120                 125             


Cys Thr Arg Cys Lys Glu Ser Ala Asp Phe Trp Cys Phe Glu Cys Glu 
    130                 135                 140                 


Gln Leu Leu Cys Ala Lys Cys Phe Glu Ala His Gln Trp Phe Leu Lys 
145                 150                 155                 160 


His Glu Ala Arg Pro Leu Ala Glu Leu Arg Asn Gln Ser Val Arg Glu 
                165                 170                 175     


Phe Leu Asp Gly Thr Arg Lys Thr Asn Asn Ile Phe Cys Ser Asn Pro 
            180                 185                 190         


Asn His Arg Thr Pro Thr Leu Thr Ser Ile Tyr Cys Arg Gly Cys Ser 
        195                 200                 205             


Lys Pro Leu Cys Cys Ser Cys Ala Leu Leu Asp Ser Ser His Ser Glu 
    210                 215                 220                 


Leu Lys Cys Asp Ile Ser Ala Glu Ile Gln Gln Arg Gln Glu Glu Leu 
225                 230                 235                 240 


Asp Ala Met Thr Gln Ala Leu Gln Glu Gln Asp Ser Ala Phe Gly Ala 
                245                 250                 255     


Val His Ala Gln Met His Ala Ala Val Gly Gln Leu Gly Arg Ala Arg 
            260                 265                 270         


Ala Glu Thr Glu Glu Leu Ile Arg Glu Arg Val Arg Gln Val Val Ala 
        275                 280                 285             


His Val Arg Ala Gln Glu Arg Glu Leu Leu Glu Ala Val Asp Ala Arg 
    290                 295                 300                 


Tyr Gln Arg Asp Tyr Glu Glu Met Ala Ser Arg Leu Gly Arg Leu Asp 
305                 310                 315                 320 


Ala Val Leu Gln Arg Ile Arg Thr Gly Ser Ala Leu Val Gln Arg Met 
                325                 330                 335     


Lys Cys Tyr Ala Ser Asp Gln Glu Val Leu Asp Met His Gly Phe Leu 
            340                 345                 350         


Arg Gln Ala Leu Cys Arg Leu Arg Gln Glu Glu Pro Gln Ser Leu Gln 
        355                 360                 365             


Ala Ala Val Arg Thr Asp Gly Phe Asp Glu Phe Lys Val Arg Leu Gln 
    370                 375                 380                 


Asp Leu Ser Ser Cys Ile Thr Gln Gly Lys Asp Ala Ala Val Ser Lys 
385                 390                 395                 400 


Lys Ala Ser Pro Glu Ala Ala Ser Thr Pro Arg Asp Pro Ile Asp Val 
                405                 410                 415     


Asp Leu Pro Glu Glu Ala Glu Arg Val Lys Ala Gln Val Gln Ala Leu 
            420                 425                 430         


Gly Leu Ala Glu Ala Gln Pro Met Ala Val Val Gln Ser Val Pro Gly 
        435                 440                 445             


Ala His Pro Val Pro Val Tyr Ala Phe Ser Ile Lys Gly Pro Ser Tyr 
    450                 455                 460                 


Gly Glu Asp Val Ser Asn Thr Thr Thr Ala Gln Lys Arg Lys Cys Ser 
465                 470                 475                 480 


Gln Thr Gln Cys Pro Arg Lys Val Ile Lys Met Glu Ser Glu Glu Gly 
                485                 490                 495     


Lys Glu Ala Arg Leu Ala Arg Ser Ser Pro Glu Gln Pro Arg Pro Ser 
            500                 505                 510         


Thr Ser Lys Ala Val Ser Pro Pro His Leu Asp Gly Pro Pro Ser Pro 
        515                 520                 525             


Arg Ser Pro Val Ile Gly Ser Glu Val Phe Leu Pro Asn Ser Asn His 
    530                 535                 540                 


Val Ala Ser Gly Ala Gly Glu Ala Glu Glu Arg Val Val Val Ile Ser 
545                 550                 555                 560 


Ser Ser Glu Asp Ser Asp Ala Glu Asn Ser Ser Ser Arg Glu Leu Asp 
                565                 570                 575     


Asp Ser Ser Ser Glu Ser Ser Asp Leu Gln Leu Glu Gly Pro Ser Thr 
            580                 585                 590         


Leu Arg Val Leu Asp Glu Asn Leu Ala Asp Pro Gln Ala Glu Asp Arg 
        595                 600                 605             


Pro Leu Val Phe Phe Asp Leu Lys Ile Asp Asn Glu Thr Gln Lys Ile 
    610                 615                 620                 


Ser Gln Leu Ala Ala Val Asn Arg Glu Ser Lys Phe Arg Val Val Ile 
625                 630                 635                 640 


Gln Pro Glu Ala Phe Phe Ser Ile Tyr Ser Lys Ala Val Ser Leu Glu 
                645                 650                 655     


Val Gly Leu Gln His Phe Leu Ser Phe Leu Ser Ser Met Arg Arg Pro 
            660                 665                 670         


Ile Leu Ala Cys Tyr Lys Leu Trp Gly Pro Gly Leu Pro Asn Phe Phe 
        675                 680                 685             


Arg Ala Leu Glu Asp Ile Asn Arg Leu Trp Glu Phe Gln Glu Ala Ile 
    690                 695                 700                 


Ser Gly Phe Leu Ala Ala Leu Pro Leu Ile Arg Glu Arg Val Pro Gly 
705                 710                 715                 720 


Ala Ser Ser Phe Lys Leu Lys Asn Leu Ala Gln Thr Tyr Leu Ala Arg 
                725                 730                 735     


Asn Met Ser Glu Arg Ser Ala Met Ala Ala Val Leu Ala Met Arg Asp 
            740                 745                 750         


Leu Cys Arg Leu Leu Glu Val Ser Pro Gly Pro Gln Leu Ala Gln His 
        755                 760                 765             


Val Tyr Pro Phe Ser Ser Leu Gln Cys Phe Ala Ser Leu Gln Pro Leu 
    770                 775                 780                 


Val Gln Ala Ala Val Leu Pro Arg Ala Glu Ala Arg Leu Leu Ala Leu 
785                 790                 795                 800 


His Asn Val Ser Phe Met Glu Leu Leu Ser Ala His Arg Arg Asp Arg 
                805                 810                 815     


Gln Gly Gly Leu Lys Lys Tyr Ser Arg Tyr Leu Ser Leu Gln Thr Thr 
            820                 825                 830         


Thr Leu Pro Pro Ala Gln Pro Ala Phe Asn Leu Gln Ala Leu Gly Thr 
        835                 840                 845             


Tyr Phe Glu Gly Leu Leu Glu Gly Pro Ala Leu Ala Arg Ala Glu Gly 
    850                 855                 860                 


Val Ser Thr Pro Leu Ala Gly Arg Gly Leu Ala Glu Arg Ala Ser Gln 
865                 870                 875                 880 


Gln Ser 
        


<210>  67
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly 
            20                  25                  30          


His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly 
        35                  40                  45              


Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg 
    50                  55                  60                  


Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser 
65                  70                  75                  80  


Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly 
                85                  90                  95      


Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp 
            100                 105                 110         


Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu 
        115                 120                 125             


Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly 
    130                 135                 140                 


Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile 
145                 150                 155                 160 


Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser 
                165                 170                 175     


Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu 
            180                 185                 190         


Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu 
        195                 200                 205             


Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala 
    210                 215                 220                 


Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser 
                245                 250                 255     


Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val 
            260                 265                 270         


Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His 
        275                 280                 285             


Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly 
305                 310                 315                 320 


Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His 
                325                 330                 335     


Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu 
            340                 345                 350         


Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His 
        355                 360                 365             


Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn 
    370                 375                 380                 


Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu 
385                 390                 395                 400 


Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly 
                405                 410                 415     


Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser 
            420                 425                 430         


Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro 
        435                 440                 445             


Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro 
    450                 455                 460                 


Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr 
465                 470                 475 


<210>  68
<211>  1050
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Met Ala Gln 
465                 470                 475                 480 


Arg Gln Gln Val Gln Arg Arg Pro Ala Pro Val Gly Leu Pro Asn Pro 
                485                 490                 495     


Arg Met Gln Gly Pro Ile Gln Gln Pro Ser Ile Ser His Gln Gln Pro 
            500                 505                 510         


Pro Pro Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly 
        515                 520                 525             


Pro Val Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln 
    530                 535                 540                 


Asn Ile Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe 
545                 550                 555                 560 


Leu Ala Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly 
                565                 570                 575     


Thr Pro Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr 
            580                 585                 590         


Ile Thr Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met 
        595                 600                 605             


Ile Asp Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu 
    610                 615                 620                 


Pro Asp Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg 
625                 630                 635                 640 


Lys Asp Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg 
                645                 650                 655     


Thr Val Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly 
            660                 665                 670         


Pro Val Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala 
        675                 680                 685             


Ser Ser Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala 
    690                 695                 700                 


Gly Ala Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile 
705                 710                 715                 720 


Arg Ile Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro 
                725                 730                 735     


Val Val Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn 
            740                 745                 750         


Ala Asn Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser 
        755                 760                 765             


Gln Ser Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp 
    770                 775                 780                 


Ser Thr Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly 
785                 790                 795                 800 


Lys Ser Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly 
                805                 810                 815     


Glu Thr Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys 
            820                 825                 830         


Gln Asn Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe 
        835                 840                 845             


His Leu Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu 
    850                 855                 860                 


Trp Ile Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr 
865                 870                 875                 880 


Asp Cys Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly 
                885                 890                 895     


Leu Val Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu 
            900                 905                 910         


Leu Phe Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val 
        915                 920                 925             


Pro Leu Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp 
    930                 935                 940                 


Leu Ser Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser 
945                 950                 955                 960 


Lys Pro Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys 
                965                 970                 975     


Ala Glu Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys 
            980                 985                 990         


Leu Glu Asn Tyr Phe Glu Glu Leu  Leu Lys Asn Leu Tyr  Pro Glu Lys 
        995                 1000                 1005             


Arg Phe  Pro Lys Pro Glu Phe  Arg Asn Glu Ser Glu  Asp Asn Lys 
    1010                 1015                 1020             


Phe Ser  Asp Asp Ser Asp Asp  Asp Phe Val Gln Pro  Arg Lys Lys 
    1025                 1030                 1035             


Arg Leu  Lys Ser Ile Glu Glu  Arg Gln Leu Leu Lys  
    1040                 1045                 1050 


<210>  69
<211>  1127
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Glu Asn Lys Gly Gly Gly Glu Ala Glu Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ser Ala Pro Val Thr Ala Gly Ala Ala Gly Pro Ala Ala Gln 
            20                  25                  30          


Glu Ala Glu Pro Pro Leu Thr Ala Val Leu Val Glu Glu Glu Glu Glu 
        35                  40                  45              


Glu Gly Gly Arg Ala Gly Ala Glu Gly Gly Ala Ala Gly Pro Asp Asp 
    50                  55                  60                  


Gly Gly Val Ala Ala Ala Ser Ser Gly Ser Ala Gln Ala Ala Ser Ser 
65                  70                  75                  80  


Pro Ala Ala Ser Val Gly Thr Gly Val Ala Gly Gly Ala Val Ser Thr 
                85                  90                  95      


Pro Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Gly Pro Ser Ala Gly 
            100                 105                 110         


Pro Pro Pro Gly Pro Pro Ala Ser Leu Leu Asp Thr Cys Ala Val Cys 
        115                 120                 125             


Gln Gln Ser Leu Gln Ser Arg Arg Glu Ala Glu Pro Lys Leu Leu Pro 
    130                 135                 140                 


Cys Leu His Ser Phe Cys Leu Arg Cys Leu Pro Glu Pro Glu Arg Gln 
145                 150                 155                 160 


Leu Ser Val Pro Ile Pro Gly Gly Ser Asn Gly Asp Ile Gln Gln Val 
                165                 170                 175     


Gly Val Ile Arg Cys Pro Val Cys Arg Gln Glu Cys Arg Gln Ile Asp 
            180                 185                 190         


Leu Val Asp Asn Tyr Phe Val Lys Asp Thr Ser Glu Ala Pro Ser Ser 
        195                 200                 205             


Ser Asp Glu Lys Ser Glu Gln Val Cys Thr Ser Cys Glu Asp Asn Ala 
    210                 215                 220                 


Ser Ala Val Gly Phe Cys Val Glu Cys Gly Glu Trp Leu Cys Lys Thr 
225                 230                 235                 240 


Cys Ile Glu Ala His Gln Arg Val Lys Phe Thr Lys Asp His Leu Ile 
                245                 250                 255     


Arg Lys Lys Glu Asp Val Ser Glu Ser Val Gly Ala Ser Gly Gln Arg 
            260                 265                 270         


Pro Val Phe Cys Pro Val His Lys Gln Glu Gln Leu Lys Leu Phe Cys 
        275                 280                 285             


Glu Thr Cys Asp Arg Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His 
    290                 295                 300                 


Lys Glu His Arg Tyr Gln Phe Leu Glu Glu Ala Phe Gln Asn Gln Lys 
305                 310                 315                 320 


Gly Ala Ile Glu Asn Leu Leu Ala Lys Leu Leu Glu Lys Lys Asn Tyr 
                325                 330                 335     


Val His Phe Ala Ala Thr Gln Val Gln Asn Arg Ile Lys Glu Val Asn 
            340                 345                 350         


Glu Thr Asn Lys Arg Val Glu Gln Glu Ile Lys Val Ala Ile Phe Thr 
        355                 360                 365             


Leu Ile Asn Glu Ile Asn Lys Lys Gly Lys Ser Leu Leu Gln Gln Leu 
    370                 375                 380                 


Glu Asn Val Thr Lys Glu Arg Gln Met Lys Leu Leu Gln Gln Gln Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Leu Ser Arg Gln Val Lys His Val Met Asn Phe Thr 
                405                 410                 415     


Asn Trp Ala Ile Ala Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys 
            420                 425                 430         


Arg Leu Ile Thr Phe Gln Leu Arg His Ile Leu Lys Ala Arg Cys Asp 
        435                 440                 445             


Pro Val Pro Ala Ala Asn Gly Ala Ile Arg Phe His Cys Asp Pro Thr 
    450                 455                 460                 


Phe Trp Ala Lys Asn Val Val Asn Leu Gly Asn Leu Val Ile Glu Ser 
465                 470                 475                 480 


Lys Pro Ala Pro Gly Tyr Thr Pro Asn Val Val Val Gly Gln Val Pro 
                485                 490                 495     


Pro Gly Thr Asn His Ile Ser Lys Thr Pro Gly Gln Ile Asn Leu Ala 
            500                 505                 510         


Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Tyr Ala Gln Lys His 
        515                 520                 525             


Gln Gln Leu Gln Gln Met Arg Met Gln Gln Pro Pro Ala Pro Val Pro 
    530                 535                 540                 


Thr Thr Thr Thr Thr Thr Gln Gln His Pro Arg Gln Ala Ala Pro Gln 
545                 550                 555                 560 


Met Leu Gln Gln Gln Pro Pro Arg Leu Ile Ser Val Gln Thr Met Gln 
                565                 570                 575     


Arg Gly Asn Met Asn Cys Gly Ala Phe Gln Ala His Gln Met Arg Leu 
            580                 585                 590         


Ala Gln Asn Ala Ala Arg Ile Pro Gly Ile Pro Arg His Ser Gly Pro 
        595                 600                 605             


Gln Tyr Ser Met Met Gln Pro His Leu Gln Arg Gln His Ser Asn Pro 
    610                 615                 620                 


Gly His Ala Gly Pro Phe Pro Val Val Ser Val His Asn Thr Thr Ile 
625                 630                 635                 640 


Asn Pro Thr Ser Pro Thr Thr Ala Thr Met Ala Asn Ala Asn Arg Gly 
                645                 650                 655     


Pro Thr Ser Pro Ser Val Thr Ala Ile Glu Leu Ile Pro Ser Val Thr 
            660                 665                 670         


Asn Pro Glu Asn Leu Pro Ser Leu Pro Asp Ile Pro Pro Ile Gln Leu 
        675                 680                 685             


Glu Asp Ala Gly Ser Ser Ser Leu Asp Asn Leu Leu Ser Arg Tyr Ile 
    690                 695                 700                 


Ser Gly Ser His Leu Pro Pro Gln Pro Thr Ser Thr Met Asn Pro Ser 
705                 710                 715                 720 


Pro Gly Pro Ser Ala Leu Ser Pro Gly Ser Ser Gly Leu Ser Asn Ser 
                725                 730                 735     


His Thr Pro Val Arg Pro Pro Ser Thr Ser Ser Thr Gly Ser Arg Gly 
            740                 745                 750         


Ser Cys Gly Ser Ser Gly Arg Thr Ala Glu Lys Thr Ser Leu Ser Phe 
        755                 760                 765             


Lys Ser Asp Gln Val Lys Val Lys Gln Glu Pro Gly Thr Glu Asp Glu 
    770                 775                 780                 


Ile Cys Ser Phe Ser Gly Gly Val Lys Gln Glu Lys Thr Glu Asp Gly 
785                 790                 795                 800 


Arg Arg Ser Ala Cys Met Leu Ser Ser Pro Glu Ser Ser Leu Thr Pro 
                805                 810                 815     


Pro Leu Ser Thr Asn Leu His Leu Glu Ser Glu Leu Asp Ala Leu Ala 
            820                 825                 830         


Ser Leu Glu Asn His Val Lys Ile Glu Pro Ala Asp Met Asn Glu Ser 
        835                 840                 845             


Cys Lys Gln Ser Gly Leu Ser Ser Leu Val Asn Gly Lys Ser Pro Ile 
    850                 855                 860                 


Arg Ser Leu Met His Arg Ser Ala Arg Ile Gly Gly Asp Gly Asn Asn 
865                 870                 875                 880 


Lys Asp Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn Gly 
                885                 890                 895     


Gly Asp Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu Thr 
            900                 905                 910         


Cys His Val Pro Thr Leu Leu Ser Phe Pro Ser Gly Asp Trp Ile Cys 
        915                 920                 925             


Thr Phe Cys Arg Asp Ile Gly Lys Pro Glu Val Glu Tyr Asp Cys Asp 
    930                 935                 940                 


Asn Leu Gln His Ser Lys Lys Gly Lys Thr Ala Gln Gly Leu Ser Pro 
945                 950                 955                 960 


Val Asp Gln Arg Lys Cys Glu Arg Leu Leu Leu Tyr Leu Tyr Cys His 
                965                 970                 975     


Glu Leu Ser Ile Glu Phe Gln Glu Pro Val Pro Ala Ser Ile Pro Asn 
            980                 985                 990         


Tyr Tyr Lys Ile Ile Lys Lys Pro  Met Asp Leu Ser Thr  Val Lys Lys 
        995                 1000                 1005             


Lys Leu  Gln Lys Lys His Ser  Gln His Tyr Gln Ile  Pro Asp Asp 
    1010                 1015                 1020             


Phe Val  Ala Asp Val Arg Leu  Ile Phe Lys Asn Cys  Glu Arg Phe 
    1025                 1030                 1035             


Asn Glu  Met Met Lys Val Val  Gln Val Tyr Ala Asp  Thr Gln Glu 
    1040                 1045                 1050             


Ile Asn  Leu Lys Ala Asp Ser  Glu Val Ala Gln Ala  Gly Lys Ala 
    1055                 1060                 1065             


Val Ala  Leu Tyr Phe Glu Asp  Lys Leu Thr Glu Ile  Tyr Ser Asp 
    1070                 1075                 1080             


Arg Thr  Phe Ala Pro Leu Pro  Glu Phe Glu Gln Glu  Glu Asp Asp 
    1085                 1090                 1095             


Gly Glu  Val Thr Glu Asp Ser  Asp Glu Asp Phe Ile  Gln Pro Arg 
    1100                 1105                 1110             


Arg Lys  Arg Leu Lys Ser Asp  Glu Arg Pro Val His  Ile Lys 
    1115                 1120                 1125         


<210>  70
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Cys Ala Arg Gly Gln Val Gly Arg Gly Thr Gln Leu Arg Thr Gly 
1               5                   10                  15      


Arg Pro Cys Ser Gln Val Pro Gly Ser Arg Trp Arg Pro Glu Arg Leu 
            20                  25                  30          


Leu Arg Arg Gln Arg Ala Gly Gly Arg Pro Ser Arg Pro His Pro Ala 
        35                  40                  45              


Arg Ala Arg Pro Gly Leu Ser Leu Pro Ala Thr Leu Leu Gly Ser Arg 
    50                  55                  60                  


Ala Ala Ala Ala Val Pro Leu Pro Leu Pro Pro Ala Leu Ala Pro Gly 
65                  70                  75                  80  


Asp Pro Ala Met Pro Val Arg Thr Glu Cys Pro Pro Pro Ala Gly Ala 
                85                  90                  95      


Ser Ala Ala Ser Ala Ala Ser Leu Ile Pro Pro Pro Pro Ile Asn Thr 
            100                 105                 110         


Gln Gln Pro Gly Val Ala Thr Ser Leu Leu Tyr Ser Gly Ser Lys Phe 
        115                 120                 125             


Arg Gly His Gln Lys Ser Lys Gly Asn Ser Tyr Asp Val Glu Val Val 
    130                 135                 140                 


Leu Gln His Val Asp Thr Gly Asn Ser Tyr Leu Cys Gly Tyr Leu Lys 
145                 150                 155                 160 


Ile Lys Gly Leu Thr Glu Glu Tyr Pro Thr Leu Thr Thr Phe Phe Glu 
                165                 170                 175     


Gly Glu Ile Ile Ser Lys Lys His Pro Phe Leu Thr Arg Lys Trp Asp 
            180                 185                 190         


Ala Asp Glu Asp Val Asp Arg Lys His Trp Gly Lys Phe Leu Ala Phe 
        195                 200                 205             


Tyr Gln Tyr Ala Lys Ser Phe Asn Ser Asp Asp Phe Asp Tyr Glu Glu 
    210                 215                 220                 


Leu Lys Asn Gly Asp Tyr Val Phe Met Arg Trp Lys Glu Gln Phe Leu 
225                 230                 235                 240 


Val Pro Asp His Thr Ile Lys Asp Ile Ser Gly Ala Ser Phe Ala Gly 
                245                 250                 255     


Phe Tyr Tyr Ile Cys Phe Gln Lys Ser Ala Ala Ser Ile Glu Gly Tyr 
            260                 265                 270         


Tyr Tyr His Arg Ser Ser Glu Trp Tyr Gln Ser Leu Asn Leu Thr His 
        275                 280                 285             


Val Pro Glu His Ser Ala Pro Ile Tyr Glu Phe Arg 
    290                 295                 300 


<210>  71
<211>  546
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gly Ser Arg Asn Ser Ser Ser Ala Gly Ser Gly Ser Gly Asp Pro 
1               5                   10                  15      


Ser Glu Gly Leu Pro Arg Arg Gly Ala Gly Leu Arg Arg Ser Glu Glu 
            20                  25                  30          


Glu Glu Glu Glu Asp Glu Asp Val Asp Leu Ala Gln Val Leu Ala Tyr 
        35                  40                  45              


Leu Leu Arg Arg Gly Gln Val Arg Leu Val Gln Gly Gly Gly Ala Ala 
    50                  55                  60                  


Asn Leu Gln Phe Ile Gln Ala Leu Leu Asp Ser Glu Glu Glu Asn Asp 
65                  70                  75                  80  


Arg Ala Trp Asp Gly Arg Leu Gly Asp Arg Tyr Asn Pro Pro Val Asp 
                85                  90                  95      


Ala Thr Pro Asp Thr Arg Glu Leu Glu Phe Asn Glu Ile Lys Thr Gln 
            100                 105                 110         


Val Glu Leu Ala Thr Gly Gln Leu Gly Leu Arg Arg Ala Ala Gln Lys 
        115                 120                 125             


His Ser Phe Pro Arg Met Leu His Gln Arg Glu Arg Gly Leu Cys His 
    130                 135                 140                 


Arg Gly Ser Phe Ser Leu Gly Glu Gln Ser Arg Val Ile Ser His Phe 
145                 150                 155                 160 


Leu Pro Asn Asp Leu Gly Phe Thr Asp Ser Tyr Ser Gln Lys Ala Phe 
                165                 170                 175     


Cys Gly Ile Tyr Ser Lys Asp Gly Gln Ile Phe Met Ser Ala Cys Gln 
            180                 185                 190         


Asp Gln Thr Ile Arg Leu Tyr Asp Cys Arg Tyr Gly Arg Phe Arg Lys 
        195                 200                 205             


Phe Lys Ser Ile Lys Ala Arg Asp Val Gly Trp Ser Val Leu Asp Val 
    210                 215                 220                 


Ala Phe Thr Pro Asp Gly Asn His Phe Leu Tyr Ser Ser Trp Ser Asp 
225                 230                 235                 240 


Tyr Ile His Ile Cys Asn Ile Tyr Gly Glu Gly Asp Thr His Thr Ala 
                245                 250                 255     


Leu Asp Leu Arg Pro Asp Glu Arg Arg Phe Ala Val Phe Ser Ile Ala 
            260                 265                 270         


Val Ser Ser Asp Gly Arg Glu Val Leu Gly Gly Ala Asn Asp Gly Cys 
        275                 280                 285             


Leu Tyr Val Phe Asp Arg Glu Gln Asn Arg Arg Thr Leu Gln Ile Glu 
    290                 295                 300                 


Ser His Glu Asp Asp Val Asn Ala Val Ala Phe Ala Asp Ile Ser Ser 
305                 310                 315                 320 


Gln Ile Leu Phe Ser Gly Gly Asp Asp Ala Ile Cys Lys Val Trp Asp 
                325                 330                 335     


Arg Arg Thr Met Arg Glu Asp Asp Pro Lys Pro Val Gly Ala Leu Ala 
            340                 345                 350         


Gly His Gln Asp Gly Ile Thr Phe Ile Asp Ser Lys Gly Asp Ala Arg 
        355                 360                 365             


Tyr Leu Ile Ser Asn Ser Lys Asp Gln Thr Ile Lys Leu Trp Asp Ile 
    370                 375                 380                 


Arg Arg Phe Ser Ser Arg Glu Gly Met Glu Ala Ser Arg Gln Ala Ala 
385                 390                 395                 400 


Thr Gln Gln Asn Trp Asp Tyr Arg Trp Gln Gln Val Pro Lys Lys Ala 
                405                 410                 415     


Trp Arg Lys Leu Lys Leu Pro Gly Asp Ser Ser Leu Met Thr Tyr Arg 
            420                 425                 430         


Gly His Gly Val Leu His Thr Leu Ile Arg Cys Arg Phe Ser Pro Ile 
        435                 440                 445             


His Ser Thr Gly Gln Gln Phe Ile Tyr Ser Gly Cys Ser Thr Gly Lys 
    450                 455                 460                 


Val Val Val Tyr Asp Leu Leu Ser Gly His Ile Val Lys Lys Leu Thr 
465                 470                 475                 480 


Asn His Lys Ala Cys Val Arg Asp Val Ser Trp His Pro Phe Glu Glu 
                485                 490                 495     


Lys Ile Val Ser Ser Ser Trp Asp Gly Asn Leu Arg Leu Trp Gln Tyr 
            500                 505                 510         


Arg Gln Ala Glu Tyr Phe Gln Asp Asp Met Pro Glu Ser Glu Glu Cys 
        515                 520                 525             


Ala Ser Ala Pro Ala Pro Val Pro Gln Ser Ser Thr Pro Phe Ser Ser 
    530                 535                 540                 


Pro Gln 
545     


