                         SEQUENCE LISTING

<110>  Arbor Biotechnologies, Inc.
 
<120>  GENE EDITING SYSTEMS COMPRISING A CRISPR NUCLEASE AND USES THEREOF

<130>  116928-0042-0001WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/299,695
<151>  2022-01-14

<150>  US 63/272,937
<151>  2021-10-28

<150>  US 63/236,047
<151>  2021-08-23

<150>  US 63/195,621
<151>  2021-06-01

<160>  259   

<170>  PatentIn version 3.5

<210>  1
<211>  3162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atgagcagcg cgatcaaaag ctacaagagc gttctgcgtc cgaacgagcg taagaaccaa       60

ctgctgaaaa gcaccattca gtgcctggaa gacggtagcg cgttcttttt caagatgctg      120

caaggcctgt ttggtggcat caccccggag attgttcgtt tcagcaccga acaggagaaa      180

cagcaacagg atatcgcgct gtggtgcgcg gttaactggt tccgtccggt gagccaagac      240

agcctgaccc acaccattgc gagcgataac ctggtggaga agtttgagga atactatggt      300

ggcaccgcga gcgacgcgat caaacagtac ttcagcgcga gcattggcga aagctactat      360

tggaacgact gccgtcaaca gtactatgat ctgtgccgtg agctgggtgt tgaggtgagc      420

gacctgaccc atgatctgga gatcctgtgc cgtgaaaagt gcctggcggt tgcgaccgag      480

agcaaccaga acaacagcat cattagcgtt ctgtttggca ccggcgaaaa agaggaccgt      540

agcgtgaaac tgcgtatcac caagaaaatt ctggaggcga tcagcaacct gaaagaaatc      600

ccgaagaacg ttgcgccgat tcaagagatc attctgaacg tggcgaaagc gaccaaggaa      660

accttccgtc aggtgtatgc gggtaacctg ggtgcgccga gcaccctgga gaaatttatc      720

gcgaaggacg gccaaaaaga gttcgatctg aagaaactgc agaccgacct gaagaaagtt      780

attcgtggta aaagcaagga gcgtgattgg tgctgccagg aagagctgcg tagctacgtg      840

gagcaaaaca ccatccagta tgacctgtgg gcgtggggcg aaatgttcaa caaagcgcac      900

accgcgctga aaatcaagag cacccgtaac tacaactttg cgaagcaacg tctggaacag      960

ttcaaagaga ttcagagcct gaacaacctg ctggttgtga agaagctgaa cgactttttc     1020

gatagcgaat ttttcagcgg cgaggaaacc tacaccatct gcgttcacca tctgggtggc     1080

aaggacctga gcaaactgta taaggcgtgg gaggatgatc cggcggaccc ggaaaacgcg     1140

attgtggttc tgtgcgacga tctgaaaaac aactttaaga aagagccgat ccgtaacatt     1200

ctgcgttaca tcttcaccat tcgtcaagaa tgcagcgcgc aggacatcct ggcggcggcg     1260

aagtacaacc aacagctgga tcgttataaa agccaaaagg cgaacccgag cgttctgggt     1320

aaccagggct ttacctggac caacgcggtg atcctgccgg agaaggcgca gcgtaacgac     1380

cgtccgaaca gcctggatct gcgtatttgg ctgtacctga aactgcgtca cccggacggt     1440

cgttggaaga aacaccatat cccgttctac gatacccgtt tcttccaaga aatttatgcg     1500

gcgggcaaca gcccggttga cacctgccag tttcgtaccc cgcgtttcgg ttatcacctg     1560

ccgaaactga ccgatcagac cgcgatccgt gttaacaaga aacatgtgaa agcggcgaag     1620

accgaggcgc gtattcgtct ggcgatccaa cagggcaccc tgccggtgag caacctgaag     1680

atcaccgaaa ttagcgcgac catcaacagc aaaggtcaag tgcgtattcc ggttaagttt     1740

gacgtgggtc gtcaaaaagg caccctgcag atcggtgacc gtttctgcgg ctacgatcaa     1800

aaccagaccg cgagccacgc gtatagcctg tgggaagtgg ttaaagaggg tcaataccat     1860

aaagagctgg gctgctttgt tcgtttcatc agcagcggtg acatcgtgag cattaccgag     1920

aaccgtggca accaatttga tcagctgagc tatgaaggtc tggcgtaccc gcaatatgcg     1980

gactggcgta agaaagcgag caagttcgtg agcctgtggc agatcaccaa gaaaaacaag     2040

aaaaaggaaa tcgtgaccgt tgaagcgaaa gagaagtttg acgcgatctg caagtaccag     2100

ccgcgtctgt ataaattcaa caaggagtac gcgtatctgc tgcgtgatat tgttcgtggc     2160

aaaagcctgg tggaactgca acagattcgt caagagatct ttcgtttcat tgaacaggac     2220

tgcggtgtta cccgtctggg cagcctgagc ctgagcaccc tggaaaccgt gaaagcggtt     2280

aagggtatca tttacagcta ttttagcacc gcgctgaacg cgagcaagaa caacccgatc     2340

agcgacgaac agcgtaaaga gtttgatccg gaactgttcg cgctgctgga aaagctggag     2400

ctgattcgta cccgtaaaaa gaaacaaaaa gtggaacgta tcgcgaacag cctgattcag     2460

acctgcctgg agaacaacat caagttcatt cgtggtgaag gcgacctgag caccaccaac     2520

aacgcgacca agaaaaaggc gaacagccgt agcatggatt ggttggcgcg tggtgttttt     2580

aacaaaatcc gtcaactggc gccgatgcac aacattaccc tgttcggttg cggcagcctg     2640

tacaccagcc accaggaccc gctggtgcat cgtaacccgg ataaagcgat gaagtgccgt     2700

tgggcggcga tcccggttaa ggacattggc gattgggtgc tgcgtaagct gagccaaaac     2760

ctgcgtgcga aaaacatcgg caccggcgag tactatcacc aaggtgttaa agagttcctg     2820

agccattatg aactgcagga cctggaggaa gagctgctga agtggcgtag cgatcgtaaa     2880

agcaacattc cgtgctgggt gctgcagaac cgtctggcgg agaagctggg caacaaagaa     2940

gcggtggttt acatcccggt tcgtggtggc cgtatttatt ttgcgaccca caaggtggcg     3000

accggtgcgg tgagcatcgt tttcgaccaa aaacaagtgt gggtttgcaa cgcggatcat     3060

gttgcggcgg cgaacatcgc gctgaccgtg aagggtattg gcgaacaaag cagcgacgaa     3120

gagaacccgg atggtagccg tatcaaactg cagctgacca gc                        3162


<210>  2
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  3
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Arg Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  4
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  5
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  6
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg 
    610                 615                 620                 


Cys Arg Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Arg  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  7
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg 
    610                 615                 620                 


Cys Arg Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Thr Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Arg  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  8
<211>  1093
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ser Asn Lys Glu Lys Asn Ala Ser Glu Thr Arg Lys Ala Tyr Thr 
1               5                   10                  15      


Thr Lys Met Ile Pro Arg Ser His Asp Arg Met Lys Leu Leu Gly Asn 
            20                  25                  30          


Phe Met Asp Tyr Leu Met Asp Gly Thr Pro Ile Phe Phe Glu Leu Trp 
        35                  40                  45              


Asn Gln Phe Gly Gly Gly Ile Asp Arg Asp Ile Ile Ser Gly Thr Ala 
    50                  55                  60                  


Asn Lys Asp Lys Ile Ser Asp Asp Leu Leu Leu Ala Val Asn Trp Phe 
65                  70                  75                  80  


Lys Val Met Pro Ile Asn Ser Lys Pro Gln Gly Val Ser Pro Ser Asn 
                85                  90                  95      


Leu Ala Asn Leu Phe Gln Gln Tyr Ser Gly Ser Glu Pro Asp Ile Gln 
            100                 105                 110         


Ala Gln Glu Tyr Phe Ala Ser Asn Phe Asp Thr Glu Lys His Gln Trp 
        115                 120                 125             


Lys Asp Met Arg Val Glu Tyr Glu Arg Leu Leu Ala Glu Leu Gln Leu 
    130                 135                 140                 


Ser Arg Ser Asp Met His His Asp Leu Lys Leu Met Tyr Lys Glu Lys 
145                 150                 155                 160 


Cys Ile Gly Leu Ser Leu Ser Thr Ala His Tyr Ile Thr Ser Val Met 
                165                 170                 175     


Phe Gly Thr Gly Ala Lys Asn Asn Arg Gln Thr Lys His Gln Phe Tyr 
            180                 185                 190         


Ser Lys Val Ile Gln Leu Leu Glu Glu Ser Thr Gln Ile Asn Ser Val 
        195                 200                 205             


Glu Gln Leu Ala Ser Ile Ile Leu Lys Ala Gly Asp Cys Asp Ser Tyr 
    210                 215                 220                 


Arg Lys Leu Arg Ile Arg Cys Ser Arg Lys Gly Ala Thr Pro Ser Ile 
225                 230                 235                 240 


Leu Lys Ile Val Gln Asp Tyr Glu Leu Gly Thr Asn His Asp Asp Glu 
                245                 250                 255     


Val Asn Val Pro Ser Leu Ile Ala Asn Leu Lys Glu Lys Leu Gly Arg 
            260                 265                 270         


Phe Glu Tyr Glu Cys Glu Trp Lys Cys Met Glu Lys Ile Lys Ala Phe 
        275                 280                 285             


Leu Ala Ser Lys Val Gly Pro Tyr Tyr Leu Gly Ser Tyr Ser Ala Met 
    290                 295                 300                 


Leu Glu Asn Ala Leu Ser Pro Ile Lys Gly Met Thr Thr Lys Asn Cys 
305                 310                 315                 320 


Lys Phe Val Leu Lys Gln Ile Asp Ala Lys Asn Asp Ile Lys Tyr Glu 
                325                 330                 335     


Asn Glu Pro Phe Gly Lys Ile Val Glu Gly Phe Phe Asp Ser Pro Tyr 
            340                 345                 350         


Phe Glu Ser Asp Thr Asn Val Lys Trp Val Leu His Pro His His Ile 
        355                 360                 365             


Gly Glu Ser Asn Ile Lys Thr Leu Trp Glu Asp Leu Asn Ala Ile His 
    370                 375                 380                 


Ser Lys Tyr Glu Glu Asp Ile Ala Ser Leu Ser Glu Asp Lys Lys Glu 
385                 390                 395                 400 


Lys Arg Ile Lys Val Tyr Gln Gly Asp Val Cys Gln Thr Ile Asn Thr 
                405                 410                 415     


Tyr Cys Glu Glu Val Gly Lys Glu Ala Lys Thr Pro Leu Val Gln Leu 
            420                 425                 430         


Leu Arg Tyr Leu Tyr Ser Arg Lys Asp Asp Ile Ala Val Asp Lys Ile 
        435                 440                 445             


Ile Asp Gly Ile Thr Phe Leu Ser Lys Lys His Lys Val Glu Lys Gln 
    450                 455                 460                 


Lys Ile Asn Pro Val Ile Gln Lys Tyr Pro Ser Phe Asn Phe Gly Asn 
465                 470                 475                 480 


Asn Ser Lys Leu Leu Gly Lys Ile Ile Ser Pro Lys Asp Lys Leu Lys 
                485                 490                 495     


His Asn Leu Lys Cys Asn Arg Asn Gln Val Asp Asn Tyr Ile Trp Ile 
            500                 505                 510         


Glu Ile Lys Val Leu Asn Thr Lys Thr Met Arg Trp Glu Lys His His 
        515                 520                 525             


Tyr Ala Leu Ser Ser Thr Arg Phe Leu Glu Glu Val Tyr Tyr Pro Ala 
    530                 535                 540                 


Thr Ser Glu Asn Pro Pro Asp Ala Leu Ala Ala Arg Phe Arg Thr Lys 
545                 550                 555                 560 


Thr Asn Gly Tyr Glu Gly Lys Pro Ala Leu Ser Ala Glu Gln Ile Glu 
                565                 570                 575     


Gln Ile Arg Ser Ala Pro Val Gly Leu Arg Lys Val Lys Lys Arg Gln 
            580                 585                 590         


Met Arg Leu Glu Ala Ala Arg Gln Gln Asn Leu Leu Pro Arg Tyr Thr 
        595                 600                 605             


Trp Gly Lys Asp Phe Asn Ile Asn Ile Cys Lys Arg Gly Asn Asn Phe 
    610                 615                 620                 


Glu Val Thr Leu Ala Thr Lys Val Lys Lys Lys Lys Glu Lys Asn Tyr 
625                 630                 635                 640 


Lys Val Val Leu Gly Tyr Asp Ala Asn Ile Val Arg Lys Asn Thr Tyr 
                645                 650                 655     


Ala Ala Ile Glu Ala His Ala Asn Gly Asp Gly Val Ile Asp Tyr Asn 
            660                 665                 670         


Asp Leu Pro Val Lys Pro Ile Glu Ser Gly Phe Val Thr Val Glu Ser 
        675                 680                 685             


Gln Val Arg Asp Lys Ser Tyr Asp Gln Leu Ser Tyr Asn Gly Val Lys 
    690                 695                 700                 


Leu Leu Tyr Cys Lys Pro His Val Glu Ser Arg Arg Ser Phe Leu Glu 
705                 710                 715                 720 


Lys Tyr Arg Asn Gly Thr Met Lys Asp Asn Arg Gly Asn Asn Ile Gln 
                725                 730                 735     


Ile Asp Phe Met Lys Asp Phe Glu Ala Ile Ala Asp Asp Glu Thr Ser 
            740                 745                 750         


Leu Tyr Tyr Phe Asn Met Lys Tyr Cys Lys Leu Leu Gln Ser Ser Ile 
        755                 760                 765             


Arg Asn His Ser Ser Gln Ala Lys Glu Tyr Arg Glu Glu Ile Phe Glu 
    770                 775                 780                 


Leu Leu Arg Asp Gly Lys Leu Ser Val Leu Lys Leu Ser Ser Leu Ser 
785                 790                 795                 800 


Asn Leu Ser Phe Val Met Phe Lys Val Ala Lys Ser Leu Ile Gly Thr 
                805                 810                 815     


Tyr Phe Gly His Leu Leu Lys Lys Pro Lys Asn Ser Lys Ser Asp Val 
            820                 825                 830         


Lys Ala Pro Pro Ile Thr Asp Glu Asp Lys Gln Lys Ala Asp Pro Glu 
        835                 840                 845             


Met Phe Ala Leu Arg Leu Ala Leu Glu Glu Lys Arg Leu Asn Lys Val 
    850                 855                 860                 


Lys Ser Lys Lys Glu Val Ile Ala Asn Lys Ile Val Ala Lys Ala Leu 
865                 870                 875                 880 


Glu Leu Arg Asp Lys Tyr Gly Pro Val Leu Ile Lys Gly Glu Asn Ile 
                885                 890                 895     


Ser Asp Thr Thr Lys Lys Gly Lys Lys Ser Ser Thr Asn Ser Phe Leu 
            900                 905                 910         


Met Asp Trp Leu Ala Arg Gly Val Ala Asn Lys Val Lys Glu Met Val 
        915                 920                 925             


Met Met His Gln Gly Leu Glu Phe Val Glu Val Asn Pro Asn Phe Thr 
    930                 935                 940                 


Ser His Gln Asp Pro Phe Val His Lys Asn Pro Glu Asn Thr Phe Arg 
945                 950                 955                 960 


Ala Arg Tyr Ser Arg Cys Thr Pro Ser Glu Leu Thr Glu Lys Asn Arg 
                965                 970                 975     


Lys Glu Ile Leu Ser Phe Leu Ser Asp Lys Pro Ser Lys Arg Pro Thr 
            980                 985                 990         


Asn Ala Tyr Tyr Asn Glu Gly Ala  Met Ala Phe Leu Ala  Thr Tyr Gly 
        995                 1000                 1005             


Leu Lys  Lys Asn Asp Val Leu  Gly Val Ser Leu Glu  Lys Phe Lys 
    1010                 1015                 1020             


Gln Ile  Met Ala Asn Ile Leu  His Gln Arg Ser Glu  Asp Gln Leu 
    1025                 1030                 1035             


Leu Phe  Pro Ser Arg Gly Gly  Met Phe Tyr Leu Ala  Thr Tyr Lys 
    1040                 1045                 1050             


Leu Asp  Ala Asp Ala Thr Ser  Val Asn Trp Asn Gly  Lys Gln Phe 
    1055                 1060                 1065             


Trp Val  Cys Asn Ala Asp Leu  Val Ala Ala Tyr Asn  Val Gly Leu 
    1070                 1075                 1080             


Val Asp  Ile Gln Lys Asp Phe  Lys Lys Lys 
    1085                 1090             


<210>  9
<211>  1074
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 
1               5                   10                  15      


Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 
            20                  25                  30          


Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 
        35                  40                  45              


Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 
    50                  55                  60                  


Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 
65                  70                  75                  80  


Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 
                85                  90                  95      


Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 
            100                 105                 110         


Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 
        115                 120                 125             


Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 
    130                 135                 140                 


Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 
145                 150                 155                 160 


Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 
                165                 170                 175     


Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 
            180                 185                 190         


Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 
        195                 200                 205             


Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 
    210                 215                 220                 


Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 
225                 230                 235                 240 


Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 
                245                 250                 255     


Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 
            260                 265                 270         


Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 
        275                 280                 285             


Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 
    290                 295                 300                 


Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 
305                 310                 315                 320 


Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 
                325                 330                 335     


Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 
            340                 345                 350         


Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 
        355                 360                 365             


Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 
    370                 375                 380                 


Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 
385                 390                 395                 400 


Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 
                405                 410                 415     


Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 
            420                 425                 430         


Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 
        435                 440                 445             


Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 
    450                 455                 460                 


Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Glu 
465                 470                 475                 480 


Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 
                485                 490                 495     


Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 
            500                 505                 510         


Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 
        515                 520                 525             


Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 
    530                 535                 540                 


Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 
545                 550                 555                 560 


Asn Thr Thr Gly Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 
                565                 570                 575     


Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Val 
            580                 585                 590         


Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 
        595                 600                 605             


Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 
    610                 615                 620                 


Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 
625                 630                 635                 640 


Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 
                645                 650                 655     


Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 
            660                 665                 670         


Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 
        675                 680                 685             


Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 
    690                 695                 700                 


Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 
705                 710                 715                 720 


Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 
                725                 730                 735     


Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 
            740                 745                 750         


Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 
        755                 760                 765             


Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 
    770                 775                 780                 


Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 
785                 790                 795                 800 


Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 
                805                 810                 815     


Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 
            820                 825                 830         


Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 
        835                 840                 845             


Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 
    850                 855                 860                 


Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 
865                 870                 875                 880 


His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 
                885                 890                 895     


Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 
            900                 905                 910         


Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 
        915                 920                 925             


Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 
    930                 935                 940                 


Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 
945                 950                 955                 960 


Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 
                965                 970                 975     


Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 
            980                 985                 990         


Gly Arg Ile Tyr Met Ala Thr Asn  Pro Val Thr Ser Asp  Ser Thr Pro 
        995                 1000                 1005             


Ile Thr  Tyr Ala Gly Lys Thr  Tyr Asn Arg Cys Asn  Ala Asp Glu 
    1010                 1015                 1020             


Val Ala  Ala Ala Asn Ile Val  Ile Ser Val Leu Ala  Pro Arg Ser 
    1025                 1030                 1035             


Lys Lys  Asn Glu Glu Gln Asp  Asp Ile Pro Leu Ile  Thr Lys Lys 
    1040                 1045                 1050             


Ala Glu  Ser Lys Ser Pro Pro  Lys Asp Arg Lys Arg  Ser Lys Thr 
    1055                 1060                 1065             


Ser Gln  Leu Pro Gln Lys 
    1070                 


<210>  10
<211>  1074
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 
1               5                   10                  15      


Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 
            20                  25                  30          


Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 
        35                  40                  45              


Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 
    50                  55                  60                  


Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 
65                  70                  75                  80  


Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 
                85                  90                  95      


Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 
            100                 105                 110         


Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 
        115                 120                 125             


Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 
    130                 135                 140                 


Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 
145                 150                 155                 160 


Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 
                165                 170                 175     


Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 
            180                 185                 190         


Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 
        195                 200                 205             


Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 
    210                 215                 220                 


Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 
225                 230                 235                 240 


Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 
                245                 250                 255     


Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 
            260                 265                 270         


Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 
        275                 280                 285             


Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 
    290                 295                 300                 


Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 
305                 310                 315                 320 


Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 
                325                 330                 335     


Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 
            340                 345                 350         


Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 
        355                 360                 365             


Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 
    370                 375                 380                 


Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 
385                 390                 395                 400 


Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 
                405                 410                 415     


Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 
            420                 425                 430         


Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 
        435                 440                 445             


Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 
    450                 455                 460                 


Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 
465                 470                 475                 480 


Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys His His Leu Pro Phe 
                485                 490                 495     


Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 
            500                 505                 510         


Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 
        515                 520                 525             


Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 
    530                 535                 540                 


Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 
545                 550                 555                 560 


Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 
                565                 570                 575     


Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 
            580                 585                 590         


Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 
        595                 600                 605             


Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 
    610                 615                 620                 


Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 
625                 630                 635                 640 


Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 
                645                 650                 655     


Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 
            660                 665                 670         


Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 
        675                 680                 685             


Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 
    690                 695                 700                 


Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 
705                 710                 715                 720 


Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 
                725                 730                 735     


Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 
            740                 745                 750         


Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 
        755                 760                 765             


Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 
    770                 775                 780                 


Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 
785                 790                 795                 800 


Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 
                805                 810                 815     


Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 
            820                 825                 830         


Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 
        835                 840                 845             


Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 
    850                 855                 860                 


Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 
865                 870                 875                 880 


His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 
                885                 890                 895     


Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 
            900                 905                 910         


Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 
        915                 920                 925             


Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 
    930                 935                 940                 


Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 
945                 950                 955                 960 


Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 
                965                 970                 975     


Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 
            980                 985                 990         


Gly Arg Ile Tyr Met Ala Thr Asn  Pro Val Thr Ser Asp  Ser Thr Pro 
        995                 1000                 1005             


Ile Thr  Tyr Ala Gly Lys Thr  Tyr Asn Arg Cys Asn  Ala Asp Glu 
    1010                 1015                 1020             


Val Ala  Ala Ala Asn Ile Val  Ile Ser Val Leu Ala  Pro Arg Ser 
    1025                 1030                 1035             


Lys Lys  Asn Arg Glu Gln Asp  Asp Ile Pro Leu Ile  Thr Lys Lys 
    1040                 1045                 1050             


Ala Glu  Ser Lys Ser Pro Pro  Lys Asp Arg Lys Arg  Ser Lys Thr 
    1055                 1060                 1065             


Ser Gln  Leu Pro Gln Lys 
    1070                 


<210>  11
<211>  1098
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ser Ile Ser Asn Asn Asn Ile Leu Pro Tyr Asn Pro Lys Leu Leu 
1               5                   10                  15      


Pro Asp Asp Arg Lys His Lys Met Leu Val Asp Thr Phe Asn Gln Leu 
            20                  25                  30          


Asp Leu Ile Arg Asn Asn Leu His Asp Met Ile Ile Ala Leu Tyr Gly 
        35                  40                  45              


Ala Leu Lys Tyr Asp Asn Ile Lys Gln Phe Ala Ser Lys Glu Lys Pro 
    50                  55                  60                  


His Ile Ser Ala Asp Ala Leu Cys Ser Ile Asn Trp Phe Arg Leu Val 
65                  70                  75                  80  


Lys Thr Asn Glu Arg Lys Pro Ala Ile Glu Ser Asn Gln Ile Ile Ser 
                85                  90                  95      


Lys Phe Ile Gln Tyr Ser Gly His Thr Pro Asp Lys Tyr Ala Leu Ser 
            100                 105                 110         


His Ile Thr Gly Asn His Glu Pro Ser His Lys Trp Ile Asp Cys Arg 
        115                 120                 125             


Glu Tyr Ala Ile Asn Tyr Ala Arg Ile Met His Leu Ser Phe Ser Gln 
    130                 135                 140                 


Phe Gln Asp Leu Ala Thr Ala Cys Leu Asn Cys Lys Ile Leu Ile Leu 
145                 150                 155                 160 


Asn Gly Thr Leu Thr Ser Ser Trp Ala Trp Gly Ala Asn Ser Ala Leu 
                165                 170                 175     


Phe Gly Gly Ser Asp Lys Glu Asn Phe Ser Val Lys Ala Lys Ile Leu 
            180                 185                 190         


Asn Ser Phe Ile Glu Asn Leu Lys Asp Glu Met Asn Thr Thr Lys Phe 
        195                 200                 205             


Gln Val Val Glu Lys Val Cys Gln Gln Ile Gly Ser Ser Asp Ala Ala 
    210                 215                 220                 


Asp Leu Phe Asp Leu Tyr Arg Ser Thr Val Lys Asp Gly Asn Arg Gly 
225                 230                 235                 240 


Pro Ala Thr Gly Arg Asn Pro Lys Val Met Asn Leu Phe Ser Gln Asp 
                245                 250                 255     


Gly Glu Ile Ser Ser Glu Gln Arg Glu Asp Phe Ile Glu Ser Phe Gln 
            260                 265                 270         


Lys Val Met Gln Glu Lys Asn Ser Lys Gln Ile Ile Pro His Leu Asp 
        275                 280                 285             


Lys Leu Lys Tyr His Leu Val Lys Gln Ser Gly Leu Tyr Asp Ile Tyr 
    290                 295                 300                 


Ser Trp Ala Ala Ala Ile Lys Asn Ala Asn Ser Thr Ile Val Ala Ser 
305                 310                 315                 320 


Asn Ser Ser Asn Leu Asn Thr Ile Leu Asn Lys Thr Glu Lys Gln Gln 
                325                 330                 335     


Thr Phe Glu Glu Leu Arg Lys Asp Glu Lys Ile Val Ala Cys Ser Lys 
            340                 345                 350         


Ile Leu Leu Ser Val Asn Asp Thr Leu Pro Glu Asp Leu His Tyr Asn 
        355                 360                 365             


Pro Ser Thr Ser Asn Leu Gly Lys Asn Leu Asp Val Phe Phe Asp Leu 
    370                 375                 380                 


Leu Asn Glu Asn Ser Val His Thr Ile Glu Asn Lys Glu Glu Lys Asn 
385                 390                 395                 400 


Lys Ile Val Lys Glu Cys Val Asn Gln Tyr Met Glu Glu Cys Lys Gly 
                405                 410                 415     


Leu Asn Lys Pro Pro Met Pro Val Leu Leu Thr Phe Ile Ser Asp Tyr 
            420                 425                 430         


Ala His Lys His Gln Ala Gln Asp Phe Leu Ser Ala Ala Lys Met Asn 
        435                 440                 445             


Phe Ile Asp Leu Lys Ile Lys Ser Ile Lys Val Val Pro Thr Val His 
    450                 455                 460                 


Gly Ser Ser Pro Tyr Thr Trp Ile Ser Asn Leu Ser Lys Lys Asn Lys 
465                 470                 475                 480 


Asp Gly Lys Met Ile Arg Thr Pro Asn Ser Ser Leu Ile Gly Trp Ile 
                485                 490                 495     


Ile Pro Pro Glu Glu Ile His Asp Gln Lys Phe Ala Gly Gln Asn Pro 
            500                 505                 510         


Ile Ile Trp Ala Val Leu Arg Val Tyr Cys Asn Asn Lys Trp Glu Met 
        515                 520                 525             


His His Phe Pro Phe Ser Asp Ser Arg Phe Phe Thr Glu Val Tyr Ala 
    530                 535                 540                 


Tyr Lys Pro Asn Leu Pro Tyr Leu Pro Gly Gly Glu Asn Arg Ser Lys 
545                 550                 555                 560 


Arg Phe Gly Tyr Arg His Ser Thr Asn Leu Ser Asn Glu Ser Arg Gln 
                565                 570                 575     


Ile Leu Leu Asp Lys Ser Lys Tyr Ala Lys Ala Asn Lys Ser Val Leu 
            580                 585                 590         


Arg Cys Met Glu Asn Met Thr His Asn Val Val Phe Asp Pro Lys Thr 
        595                 600                 605             


Ser Leu Asn Ile Arg Ile Lys Thr Asp Lys Asn Asn Ser Pro Val Leu 
    610                 615                 620                 


Asp Asp Lys Gly Arg Ile Thr Phe Val Met Gln Ile Asn His Arg Ile 
625                 630                 635                 640 


Leu Glu Lys Tyr Asn Asn Thr Lys Ile Glu Ile Gly Asp Arg Ile Leu 
                645                 650                 655     


Ala Tyr Asp Gln Asn Gln Ser Glu Asn His Thr Tyr Ala Ile Leu Gln 
            660                 665                 670         


Arg Thr Glu Glu Gly Ser His Ala His Gln Phe Asn Gly Trp Tyr Val 
        675                 680                 685             


Arg Val Leu Glu Thr Gly Lys Val Thr Ser Ile Val Gln Gly Leu Ser 
    690                 695                 700                 


Gly Pro Ile Asp Gln Leu Asn Tyr Asp Gly Met Pro Val Thr Ser His 
705                 710                 715                 720 


Lys Phe Asn Cys Trp Gln Ala Asp Arg Ser Ala Phe Val Ser Gln Phe 
                725                 730                 735     


Ala Ser Leu Lys Ile Ser Glu Thr Glu Thr Phe Asp Glu Ala Tyr Gln 
            740                 745                 750         


Ala Ile Asn Ala Gln Gly Ala Tyr Thr Trp Asn Leu Phe Tyr Leu Arg 
        755                 760                 765             


Ile Leu Arg Lys Ala Leu Arg Val Cys His Met Glu Asn Ile Asn Gln 
    770                 775                 780                 


Phe Arg Glu Glu Ile Leu Ala Ile Ser Lys Asn Arg Leu Ser Pro Met 
785                 790                 795                 800 


Ser Leu Gly Ser Leu Ser Gln Asn Ser Leu Lys Met Ile Arg Ala Phe 
                805                 810                 815     


Lys Ser Ile Ile Asn Cys Tyr Met Ser Arg Met Ser Phe Val Asp Glu 
            820                 825                 830         


Leu Gln Lys Lys Glu Gly Asp Leu Glu Leu His Thr Ile Met Arg Leu 
        835                 840                 845             


Thr Asp Asn Lys Leu Asn Asp Lys Arg Val Glu Lys Ile Asn Arg Ala 
    850                 855                 860                 


Ser Ser Phe Leu Thr Asn Lys Ala His Ser Met Gly Cys Lys Met Ile 
865                 870                 875                 880 


Val Gly Glu Ser Asp Leu Pro Val Ala Asp Ser Lys Thr Ser Lys Lys 
                885                 890                 895     


Gln Asn Val Asp Arg Met Asp Trp Cys Ala Arg Ala Leu Ser His Lys 
            900                 905                 910         


Val Glu Tyr Ala Cys Lys Leu Met Gly Leu Ala Tyr Arg Gly Ile Pro 
        915                 920                 925             


Ala Tyr Met Ser Ser His Gln Asp Pro Leu Val His Leu Val Glu Ser 
    930                 935                 940                 


Lys Arg Ser Val Leu Arg Pro Arg Phe Val Val Ala Asp Lys Ser Asp 
945                 950                 955                 960 


Val Lys Gln His His Leu Asp Asn Leu Arg Arg Met Leu Asn Ser Lys 
                965                 970                 975     


Thr Lys Val Gly Thr Ala Val Tyr Tyr Arg Glu Ala Val Glu Leu Met 
            980                 985                 990         


Cys Glu Glu Leu Gly Ile His Lys  Thr Asp Met Ala Lys  Gly Lys Val 
        995                 1000                 1005             


Ser Leu  Ser Asp Phe Val Asp  Lys Phe Ile Gly Glu  Lys Ala Ile 
    1010                 1015                 1020             


Phe Pro  Gln Arg Gly Gly Arg  Phe Tyr Met Ser Thr  Lys Arg Leu 
    1025                 1030                 1035             


Thr Thr  Gly Ala Lys Leu Ile  Cys Tyr Ser Gly Ser  Asp Val Trp 
    1040                 1045                 1050             


Leu Ser  Asp Ala Asp Glu Ile  Ala Ala Ile Asn Ile  Gly Met Phe 
    1055                 1060                 1065             


Val Val  Cys Asp Gln Thr Gly  Ala Phe Lys Lys Lys  Lys Lys Glu 
    1070                 1075                 1080             


Lys Leu  Asp Asp Glu Glu Cys  Asp Ile Leu Pro Phe  Arg Pro Met 
    1085                 1090                 1095             


<210>  12
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
guuggaauga cuaauuuuug ugcccaccgu uggcac                                 36


<210>  13
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
aauuuuugug cccaucguug gcac                                              24


<210>  14
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
auuuuugugc ccaucguugg cac                                               23


<210>  15
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
guugcaaaac ccaagaaauc cgucuuucau ugacgg                                 36


<210>  16
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gcaacaccua agaaauccgu cuuucauuga cggg                                   34


<210>  17
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
agaaauccgu cuuucauuga cgg                                               23


<210>  18
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
cuagcaauga ccuaauagug uguccuuagu ugacau                                 36


<210>  19
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ccuacaauac cuaagaaauc cguccuaagu ugacgg                                 36


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
auaguguguc cuuaguugac au                                                22


<210>  21
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
guuggaauga cuaauuuuug ugcccaccgu uggcac                                 36


<210>  22
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
cccacaauac cugagaaauc cguccuacgu ugacgg                                 36


<210>  23
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ucucaacgau agucagacau guguccucag ugacac                                 36


<210>  24
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
agacaugugu ccucagugac ac                                                22


<210>  25
<211>  1798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys Ala His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1055                 1060                 1065             


Lys Lys  Ser Gly Gly Ser Ser  Gly Gly Ser Ser Gly  Ser Glu Thr 
    1070                 1075                 1080             


Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Ser  Gly Gly Ser 
    1085                 1090                 1095             


Ser Gly  Gly Ser Thr Leu Asn  Ile Glu Asp Glu Tyr  Arg Leu His 
    1100                 1105                 1110             


Glu Thr  Ser Lys Glu Pro Asp  Val Ser Leu Gly Ser  Thr Trp Leu 
    1115                 1120                 1125             


Ser Asp  Phe Pro Gln Ala Trp  Ala Glu Thr Gly Gly  Met Gly Leu 
    1130                 1135                 1140             


Ala Val  Arg Gln Ala Pro Leu  Ile Ile Pro Leu Lys  Ala Thr Ser 
    1145                 1150                 1155             


Thr Pro  Val Ser Ile Lys Gln  Tyr Pro Met Ser Gln  Glu Ala Arg 
    1160                 1165                 1170             


Leu Gly  Ile Lys Pro His Ile  Gln Arg Leu Leu Asp  Gln Gly Ile 
    1175                 1180                 1185             


Leu Val  Pro Cys Gln Ser Pro  Trp Asn Thr Pro Leu  Leu Pro Val 
    1190                 1195                 1200             


Lys Lys  Pro Gly Thr Asn Asp  Tyr Arg Pro Val Gln  Asp Leu Arg 
    1205                 1210                 1215             


Glu Val  Asn Lys Arg Val Glu  Asp Ile His Pro Thr  Val Pro Asn 
    1220                 1225                 1230             


Pro Tyr  Asn Leu Leu Ser Gly  Leu Pro Pro Ser His  Gln Trp Tyr 
    1235                 1240                 1245             


Thr Val  Leu Asp Leu Lys Asp  Ala Phe Phe Cys Leu  Arg Leu His 
    1250                 1255                 1260             


Pro Thr  Ser Gln Pro Leu Phe  Ala Phe Glu Trp Arg  Asp Pro Glu 
    1265                 1270                 1275             


Met Gly  Ile Ser Gly Gln Leu  Thr Trp Thr Arg Leu  Pro Gln Gly 
    1280                 1285                 1290             


Phe Lys  Asn Ser Pro Thr Leu  Phe Asn Glu Ala Leu  His Arg Asp 
    1295                 1300                 1305             


Leu Ala  Asp Phe Arg Ile Gln  His Pro Asp Leu Ile  Leu Leu Gln 
    1310                 1315                 1320             


Tyr Val  Asp Asp Leu Leu Leu  Ala Ala Thr Ser Glu  Leu Asp Cys 
    1325                 1330                 1335             


Gln Gln  Gly Thr Arg Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly 
    1340                 1345                 1350             


Tyr Arg  Ala Ser Ala Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val 
    1355                 1360                 1365             


Lys Tyr  Leu Gly Tyr Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr 
    1370                 1375                 1380             


Glu Ala  Arg Lys Glu Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr 
    1385                 1390                 1395             


Pro Arg  Gln Leu Arg Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg 
    1400                 1405                 1410             


Leu Phe  Ile Pro Gly Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro 
    1415                 1420                 1425             


Leu Thr  Lys Pro Gly Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln 
    1430                 1435                 1440             


Lys Ala  Tyr Gln Glu Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala 
    1445                 1450                 1455             


Leu Gly  Leu Pro Asp Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp 
    1460                 1465                 1470             


Glu Lys  Gln Gly Tyr Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly 
    1475                 1480                 1485             


Pro Trp  Arg Arg Pro Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro 
    1490                 1495                 1500             


Val Ala  Ala Gly Trp Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile 
    1505                 1510                 1515             


Ala Val  Leu Thr Lys Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro 
    1520                 1525                 1530             


Leu Val  Ile Leu Ala Pro His  Ala Val Glu Ala Leu  Val Lys Gln 
    1535                 1540                 1545             


Pro Pro  Asp Arg Trp Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln 
    1550                 1555                 1560             


Ala Leu  Leu Leu Asp Thr Asp  Arg Val Gln Phe Gly  Pro Val Val 
    1565                 1570                 1575             


Ala Leu  Asn Pro Ala Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu 
    1580                 1585                 1590             


Gln His  Asn Cys Leu Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg 
    1595                 1600                 1605             


Pro Asp  Leu Thr Asp Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp 
    1610                 1615                 1620             


Tyr Thr  Asp Gly Ser Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala 
    1625                 1630                 1635             


Gly Ala  Ala Val Thr Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala 
    1640                 1645                 1650             


Leu Pro  Ala Gly Thr Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu 
    1655                 1660                 1665             


Thr Gln  Ala Leu Lys Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr 
    1670                 1675                 1680             


Thr Asp  Ser Arg Tyr Ala Phe  Ala Thr Ala His Ile  His Gly Glu 
    1685                 1690                 1695             


Ile Tyr  Arg Arg Arg Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile 
    1700                 1705                 1710             


Lys Asn  Lys Asp Glu Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu 
    1715                 1720                 1725             


Pro Lys  Arg Leu Ser Ile Ile  His Cys Pro Gly His  Gln Lys Gly 
    1730                 1735                 1740             


His Ser  Ala Glu Ala Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala 
    1745                 1750                 1755             


Arg Lys  Ala Ala Ile Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu 
    1760                 1765                 1770             


Ile Glu  Asn Ser Ser Pro Met  Lys Arg Thr Ala Asp  Gly Ser Glu 
    1775                 1780                 1785             


Phe Glu  Ser Pro Lys Lys Lys  Arg Lys Val 
    1790                 1795             


<210>  26
<211>  1798
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Met Ser Ser Ala Ile Lys Ser Tyr 
                725                 730                 735     


Lys Ser Val Leu Arg Pro Asn Glu Arg Lys Asn Gln Leu Leu Lys Ser 
            740                 745                 750         


Thr Ile Gln Cys Leu Glu Asp Gly Ser Ala Phe Phe Phe Lys Met Leu 
        755                 760                 765             


Gln Gly Leu Phe Gly Gly Ile Thr Pro Glu Ile Val Arg Phe Ser Thr 
    770                 775                 780                 


Glu Gln Glu Lys Gln Gln Gln Asp Ile Ala Leu Trp Cys Ala Val Asn 
785                 790                 795                 800 


Trp Phe Arg Pro Val Ser Gln Asp Ser Leu Thr His Thr Ile Ala Ser 
                805                 810                 815     


Asp Asn Leu Val Glu Lys Phe Glu Glu Tyr Tyr Gly Gly Thr Ala Ser 
            820                 825                 830         


Asp Ala Ile Lys Gln Tyr Phe Ser Ala Ser Ile Gly Glu Ser Tyr Tyr 
        835                 840                 845             


Trp Asn Asp Cys Arg Gln Gln Tyr Tyr Asp Leu Cys Arg Glu Leu Gly 
    850                 855                 860                 


Val Glu Val Ser Asp Leu Thr His Asp Leu Glu Ile Leu Cys Arg Glu 
865                 870                 875                 880 


Lys Cys Leu Ala Val Ala Thr Glu Ser Asn Gln Asn Asn Ser Ile Ile 
                885                 890                 895     


Ser Val Leu Phe Gly Thr Gly Glu Lys Glu Asp Arg Ser Val Lys Leu 
            900                 905                 910         


Arg Ile Thr Lys Lys Ile Leu Glu Ala Ile Ser Asn Leu Lys Glu Ile 
        915                 920                 925             


Pro Lys Asn Val Ala Pro Ile Gln Glu Ile Ile Leu Asn Val Ala Lys 
    930                 935                 940                 


Ala Thr Lys Glu Thr Phe Arg Gln Val Tyr Ala Gly Asn Leu Gly Ala 
945                 950                 955                 960 


Pro Ser Thr Leu Glu Lys Phe Ile Ala Lys Asp Gly Gln Lys Glu Phe 
                965                 970                 975     


Asp Leu Lys Lys Leu Gln Thr Asp Leu Lys Lys Val Ile Arg Gly Lys 
            980                 985                 990         


Ser Lys Glu Arg Asp Trp Cys Cys  Gln Glu Glu Leu Arg  Ser Tyr Val 
        995                 1000                 1005             


Glu Gln  Asn Thr Ile Gln Tyr  Asp Leu Trp Ala Trp  Gly Glu Met 
    1010                 1015                 1020             


Phe Asn  Lys Ala His Thr Ala  Leu Lys Ile Lys Ser  Thr Arg Asn 
    1025                 1030                 1035             


Tyr Asn  Phe Ala Lys Gln Arg  Leu Glu Gln Phe Lys  Glu Ile Gln 
    1040                 1045                 1050             


Ser Leu  Asn Asn Leu Leu Val  Val Lys Lys Leu Asn  Asp Phe Phe 
    1055                 1060                 1065             


Asp Ser  Glu Phe Phe Ser Gly  Glu Glu Thr Tyr Thr  Ile Cys Val 
    1070                 1075                 1080             


His His  Leu Gly Gly Lys Asp  Leu Ser Lys Leu Tyr  Lys Ala Trp 
    1085                 1090                 1095             


Glu Asp  Asp Pro Ala Asp Pro  Glu Asn Ala Ile Val  Val Leu Cys 
    1100                 1105                 1110             


Asp Asp  Leu Lys Asn Asn Phe  Lys Lys Glu Pro Ile  Arg Asn Ile 
    1115                 1120                 1125             


Leu Arg  Tyr Ile Phe Thr Ile  Arg Gln Glu Cys Ser  Ala Gln Asp 
    1130                 1135                 1140             


Ile Leu  Ala Ala Ala Lys Tyr  Asn Gln Gln Leu Asp  Arg Tyr Lys 
    1145                 1150                 1155             


Ser Gln  Lys Ala Asn Pro Ser  Val Leu Gly Asn Gln  Gly Phe Thr 
    1160                 1165                 1170             


Trp Thr  Asn Ala Val Ile Leu  Pro Glu Lys Ala Gln  Arg Asn Asp 
    1175                 1180                 1185             


Arg Pro  Asn Ser Leu Asp Leu  Arg Ile Trp Leu Tyr  Leu Lys Leu 
    1190                 1195                 1200             


Arg His  Pro Asp Gly Arg Trp  Lys Lys Ala His Ile  Pro Phe Tyr 
    1205                 1210                 1215             


Asp Thr  Arg Phe Phe Gln Glu  Ile Tyr Ala Ala Gly  Asn Ser Pro 
    1220                 1225                 1230             


Val Asp  Thr Cys Gln Phe Arg  Thr Pro Arg Phe Gly  Tyr His Leu 
    1235                 1240                 1245             


Pro Lys  Leu Thr Asp Gln Thr  Ala Ile Arg Val Asn  Lys Lys His 
    1250                 1255                 1260             


Val Lys  Ala Ala Lys Thr Glu  Ala Arg Ile Arg Leu  Ala Ile Gln 
    1265                 1270                 1275             


Gln Gly  Thr Leu Pro Val Ser  Asn Leu Lys Ile Thr  Glu Ile Ser 
    1280                 1285                 1290             


Ala Thr  Ile Asn Ser Lys Gly  Gln Val Arg Ile Pro  Val Lys Phe 
    1295                 1300                 1305             


Arg Val  Gly Arg Gln Lys Gly  Thr Leu Gln Ile Gly  Asp Arg Phe 
    1310                 1315                 1320             


Cys Gly  Tyr Asp Gln Asn Gln  Thr Ala Ser His Ala  Tyr Ser Leu 
    1325                 1330                 1335             


Trp Glu  Val Val Lys Glu Gly  Gln Tyr His Lys Glu  Leu Gly Cys 
    1340                 1345                 1350             


Phe Val  Arg Phe Ile Ser Ser  Gly Asp Ile Val Ser  Ile Thr Glu 
    1355                 1360                 1365             


Asn Arg  Gly Asn Gln Phe Asp  Gln Leu Ser Tyr Glu  Gly Leu Ala 
    1370                 1375                 1380             


Tyr Pro  Gln Tyr Ala Asp Trp  Arg Lys Lys Ala Ser  Lys Phe Val 
    1385                 1390                 1395             


Ser Leu  Trp Gln Ile Thr Lys  Lys Asn Lys Lys Lys  Glu Ile Val 
    1400                 1405                 1410             


Thr Val  Glu Ala Lys Glu Lys  Phe Asp Ala Ile Cys  Lys Tyr Gln 
    1415                 1420                 1425             


Pro Arg  Leu Tyr Lys Phe Asn  Lys Glu Tyr Ala Tyr  Leu Leu Arg 
    1430                 1435                 1440             


Asp Ile  Val Arg Gly Lys Ser  Leu Val Glu Leu Gln  Gln Ile Arg 
    1445                 1450                 1455             


Gln Glu  Ile Phe Arg Phe Ile  Glu Gln Asp Cys Gly  Val Thr Arg 
    1460                 1465                 1470             


Leu Gly  Ser Leu Ser Leu Ser  Thr Leu Glu Thr Val  Lys Ala Val 
    1475                 1480                 1485             


Lys Gly  Ile Ile Tyr Ser Tyr  Phe Ser Thr Ala Leu  Asn Ala Ser 
    1490                 1495                 1500             


Lys Asn  Asn Pro Ile Ser Asp  Glu Gln Arg Lys Glu  Phe Asp Pro 
    1505                 1510                 1515             


Glu Leu  Phe Ala Leu Leu Glu  Lys Leu Glu Leu Ile  Arg Thr Arg 
    1520                 1525                 1530             


Lys Lys  Lys Gln Lys Val Glu  Arg Ile Ala Asn Ser  Leu Ile Gln 
    1535                 1540                 1545             


Thr Cys  Leu Glu Asn Asn Ile  Lys Phe Ile Arg Gly  Glu Gly Asp 
    1550                 1555                 1560             


Leu Ser  Thr Thr Asn Asn Ala  Thr Lys Lys Lys Ala  Asn Ser Arg 
    1565                 1570                 1575             


Ser Met  Asp Trp Leu Ala Arg  Gly Val Phe Asn Lys  Ile Arg Gln 
    1580                 1585                 1590             


Leu Ala  Pro Met His Asn Ile  Thr Leu Phe Gly Cys  Gly Ser Leu 
    1595                 1600                 1605             


Tyr Thr  Ser His Gln Asp Pro  Leu Val His Arg Asn  Pro Asp Lys 
    1610                 1615                 1620             


Ala Met  Lys Cys Arg Trp Ala  Ala Ile Pro Val Lys  Asp Ile Gly 
    1625                 1630                 1635             


Asp Trp  Val Leu Arg Lys Leu  Ser Gln Asn Leu Arg  Ala Lys Asn 
    1640                 1645                 1650             


Arg Gly  Thr Gly Glu Tyr Tyr  His Gln Gly Val Lys  Glu Phe Leu 
    1655                 1660                 1665             


Ser His  Tyr Glu Leu Gln Asp  Leu Glu Glu Glu Leu  Leu Lys Trp 
    1670                 1675                 1680             


Arg Ser  Asp Arg Lys Ser Asn  Ile Pro Cys Trp Val  Leu Gln Asn 
    1685                 1690                 1695             


Arg Leu  Ala Glu Lys Leu Gly  Asn Lys Glu Ala Val  Val Tyr Ile 
    1700                 1705                 1710             


Pro Val  Arg Gly Gly Arg Ile  Tyr Phe Ala Thr His  Lys Val Ala 
    1715                 1720                 1725             


Thr Gly  Ala Val Ser Ile Val  Phe Asp Gln Lys Gln  Val Trp Val 
    1730                 1735                 1740             


Cys Asn  Ala Asp His Val Ala  Ala Ala Asn Ile Ala  Leu Thr Gly 
    1745                 1750                 1755             


Lys Gly  Ile Gly Glu Gln Ser  Ser Asp Glu Glu Asn  Pro Asp Gly 
    1760                 1765                 1770             


Ser Arg  Ile Lys Leu Gln Leu  Thr Ser Lys Arg Pro  Ala Ala Thr 
    1775                 1780                 1785             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1790                 1795             


<210>  27
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cag                         43


<210>  28
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (40)..(43)
<223>  modified with phosphorothioate

<400>  28
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cag                         43


<210>  29
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Met Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys 
1               5                   10                  15      


Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro 
        35                  40                  45              


Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln 
    50                  55                  60                  


Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln 
65                  70                  75                  80  


Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His 
    130                 135                 140                 


Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly 
225                 230                 235                 240 


Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr 
            260                 265                 270         


Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr 
        275                 280                 285             


Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe 
    290                 295                 300                 


Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn 
                325                 330                 335     


Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu 
            340                 345                 350         


Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro 
            420                 425                 430         


Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro 
        435                 440                 445             


Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu 
    450                 455                 460                 


Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys 
                485                 490                 495     


Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp 
            500                 505                 510         


Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser 
        515                 520                 525             


Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu 
    530                 535                 540                 


Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln 
545                 550                 555                 560 


Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly 
                565                 570                 575     


Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala 
            580                 585                 590         


His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu 
        595                 600                 605             


Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala 
    610                 615                 620                 


Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln 
625                 630                 635                 640 


Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala 
                645                 650                 655     


Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu 
            660                 665                 670         


Ile Glu Asn Ser Ser Pro 
        675             


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
gtagcctctc ccgctctggt                                                   20


<210>  31
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  modified with 2'-O-methylation

<400>  31
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cag                         43


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gggaagtggt tggtcagcat                                                   20


<210>  33
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (40)..(43)
<223>  modified with phosphorothioate

<400>  33
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cag                         43


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
gagccagtgt tgctagtcaa                                                   20


<210>  35
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca                                        90


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
aatcctccac cagtcatggt                                                   20


<210>  37
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (87)..(90)
<223>  modified with phosphorothioate

<400>  37
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca                                        90


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
ttaaactctc catggaccag                                                   20


<210>  39
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (87)..(89)
<223>  modified with 2'-O-methylation

<400>  39
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca                                        90


<210>  40
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
agaaauccgu cuuucauuga cggguagccu cucccgcucu ggugacauuc uuuguagccu       60

cuccccgagu gguucagggc ccagcuaggg auccagaucu gggugauuua ggcucccucu      120

gucuggauca guccucc                                                     137


<210>  41
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
agaaauccgu cuuucauuga cggguagccu cucccgcucu ggugacauuc uuuguagccu       60

cuccccgagu gguucagggc ccagcuaggg auccagaucu gggugau                    107


<210>  42
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
agaaauccgu cuuucauuga cggguagccu cucccgcucu ggugcacccc cauaaggggg       60

gacauucuuu guagccucuc cccgaguggu ucagggccca gcuaggg                    107


<210>  43
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
agaaauccgu cuuucauuga cggguagccu cucccgcucu ggugacauuc uuuguagccu       60

cuccccgagu gguucagggc ccagcuaggg                                        90


<210>  44
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
agaaauccgu cuuucauuga cggguagccu cucccgcucu ggugacauuc uuuguagccu       60

cucccagcgg cucugguuca gggcccagcu aggg                                   94


<210>  45
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
agaaauccgu cuuucauuga cggguagccu cucccgcucu ggugacauuc uuuguagccu       60

cucccugguu cagggcccag cuaggg                                            86


<210>  46
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (87)..(89)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (87)..(90)
<223>  modified with phosphorothioate

<400>  46
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca                                        90


<210>  47
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaa                    107


<210>  48
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (104)..(107)
<223>  modified with phosphorothioate

<400>  48
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaa                    107


<210>  49
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (104)..(106)
<223>  modified with 2'-O-methylation

<400>  49
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaa                    107


<210>  50
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  modified with phosphorothioate

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (104)..(106)
<223>  modified with 2'-O-methylation

<220>
<221>  misc_feature
<222>  (104)..(107)
<223>  modified with phosphorothioate

<400>  50
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaa                    107


<210>  51
<211>  1074
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Met Ala Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala 
1               5                   10                  15      


Arg Lys Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly 
            20                  25                  30          


Gln Arg Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr 
        35                  40                  45              


Leu Glu Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val 
    50                  55                  60                  


Cys Ala Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys 
65                  70                  75                  80  


Asp Gly Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser 
                85                  90                  95      


Gly Lys Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser 
            100                 105                 110         


Ser Asp Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe 
        115                 120                 125             


Gln Arg Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met 
    130                 135                 140                 


Leu Phe Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr 
145                 150                 155                 160 


Ala Ala Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser 
                165                 170                 175     


Lys Lys Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn 
            180                 185                 190         


Glu Asn Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu 
        195                 200                 205             


Asn Ala Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala 
    210                 215                 220                 


Gly Gly Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met 
225                 230                 235                 240 


Val Ser Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val 
                245                 250                 255     


Leu Lys Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu 
            260                 265                 270         


Lys Gln Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val 
        275                 280                 285             


Tyr Ser Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr 
    290                 295                 300                 


Thr Arg Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu 
305                 310                 315                 320 


Leu Lys Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val 
                325                 330                 335     


Leu Asn Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe 
            340                 345                 350         


Asn Ile Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser 
        355                 360                 365             


Lys Leu Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly 
    370                 375                 380                 


Ile Gln Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro 
385                 390                 395                 400 


Ile Arg Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser 
                405                 410                 415     


Ala Glu Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys 
            420                 425                 430         


Ile Ser Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp 
        435                 440                 445             


Ala Phe Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys 
    450                 455                 460                 


Arg His Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg 
465                 470                 475                 480 


Ala Glu Leu His Tyr Asp Gly Lys Lys Ala Lys Ala His Leu Pro Phe 
                485                 490                 495     


Tyr Asn Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val 
            500                 505                 510         


Ala Glu Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly 
        515                 520                 525             


Lys Asp Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr 
    530                 535                 540                 


Lys Lys Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala 
545                 550                 555                 560 


Asn Thr Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys 
                565                 570                 575     


Arg Glu Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg 
            580                 585                 590         


Asp Arg Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp 
        595                 600                 605             


Arg Asn Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro 
    610                 615                 620                 


Pro Gly Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr 
625                 630                 635                 640 


Ile Lys Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser 
                645                 650                 655     


Thr Thr Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg 
            660                 665                 670         


Phe Lys Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile 
        675                 680                 685             


Arg Gln Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile 
    690                 695                 700                 


Pro Glu Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val 
705                 710                 715                 720 


Phe Asn Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala 
                725                 730                 735     


Lys Lys Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser 
            740                 745                 750         


Lys Asp Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp 
        755                 760                 765             


Ala Ser Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr 
    770                 775                 780                 


Phe Asn Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn 
785                 790                 795                 800 


Pro Val Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn 
                805                 810                 815     


Lys Arg Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu 
            820                 825                 830         


Ala Leu Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly 
        835                 840                 845             


Glu Val Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp 
    850                 855                 860                 


Trp Cys Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe 
865                 870                 875                 880 


His Gly Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln 
                885                 890                 895     


Asp Pro Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala 
            900                 905                 910         


Arg Phe Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg 
        915                 920                 925             


Asn Phe Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr 
    930                 935                 940                 


Lys Gln Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His 
945                 950                 955                 960 


Ala Glu Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys 
                965                 970                 975     


Ile Leu Glu Asp Lys Asn Leu Thr Ser Val Ile Ile Pro Lys Arg Gly 
            980                 985                 990         


Gly Arg Ile Tyr Met Ala Thr Asn  Pro Val Thr Ser Asp  Ser Thr Pro 
        995                 1000                 1005             


Ile Thr  Tyr Ala Gly Lys Thr  Tyr Asn Arg Cys Asn  Ala Asp Glu 
    1010                 1015                 1020             


Val Ala  Ala Ala Asn Ile Val  Ile Ser Val Leu Ala  Pro Arg Ser 
    1025                 1030                 1035             


Lys Lys  Asn Arg Glu Gln Asp  Asp Ile Pro Leu Ile  Thr Lys Lys 
    1040                 1045                 1050             


Ala Glu  Ser Lys Ser Pro Pro  Lys Asp Arg Lys Arg  Ser Lys Thr 
    1055                 1060                 1065             


Ser Gln  Leu Pro Gln Lys 
    1070                 


<210>  52
<211>  1832
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Lys Ile Glu Glu Gly Lys Gly His His His His His His Met Ala 
1               5                   10                  15      


Ser Ile Ser Arg Pro Tyr Gly Thr Lys Leu Arg Pro Asp Ala Arg Lys 
            20                  25                  30          


Lys Glu Met Leu Asp Lys Phe Phe Asn Thr Leu Thr Lys Gly Gln Arg 
        35                  40                  45              


Val Phe Ala Asp Leu Ala Leu Cys Ile Tyr Gly Ser Leu Thr Leu Glu 
    50                  55                  60                  


Met Ala Lys Ser Leu Glu Pro Glu Ser Asp Ser Glu Leu Val Cys Ala 
65                  70                  75                  80  


Ile Gly Trp Phe Arg Leu Val Asp Lys Thr Ile Trp Ser Lys Asp Gly 
                85                  90                  95      


Ile Lys Gln Glu Asn Leu Val Lys Gln Tyr Glu Ala Tyr Ser Gly Lys 
            100                 105                 110         


Glu Ala Ser Glu Val Val Lys Thr Tyr Leu Asn Ser Pro Ser Ser Asp 
        115                 120                 125             


Lys Tyr Val Trp Ile Asp Cys Arg Gln Lys Phe Leu Arg Phe Gln Arg 
    130                 135                 140                 


Glu Leu Gly Thr Arg Asn Leu Ser Glu Asp Phe Glu Cys Met Leu Phe 
145                 150                 155                 160 


Glu Gln Tyr Ile Arg Leu Thr Lys Gly Glu Ile Glu Gly Tyr Ala Ala 
                165                 170                 175     


Ile Ser Asn Met Phe Gly Asn Gly Glu Lys Glu Asp Arg Ser Lys Lys 
            180                 185                 190         


Arg Met Tyr Ala Thr Arg Met Lys Asp Trp Leu Glu Ala Asn Glu Asn 
        195                 200                 205             


Ile Thr Trp Glu Gln Tyr Arg Glu Ala Leu Lys Asn Gln Leu Asn Ala 
    210                 215                 220                 


Lys Asn Leu Glu Gln Val Val Ala Asn Tyr Lys Gly Asn Ala Gly Gly 
225                 230                 235                 240 


Ala Asp Pro Phe Phe Lys Tyr Ser Phe Ser Lys Glu Gly Met Val Ser 
                245                 250                 255     


Lys Lys Glu His Ala Gln Gln Leu Asp Lys Phe Lys Thr Val Leu Lys 
            260                 265                 270         


Asn Lys Ala Arg Asp Leu Asn Phe Pro Asn Lys Glu Lys Leu Lys Gln 
        275                 280                 285             


Tyr Leu Glu Ala Glu Ile Gly Ile Pro Val Asp Ala Asn Val Tyr Ser 
    290                 295                 300                 


Gln Met Phe Ser Asn Gly Val Ser Glu Val Gln Pro Lys Thr Thr Arg 
305                 310                 315                 320 


Asn Met Ser Phe Ser Asn Glu Lys Leu Asp Leu Leu Thr Glu Leu Lys 
                325                 330                 335     


Asp Leu Asn Lys Gly Asp Gly Phe Glu Tyr Ala Arg Glu Val Leu Asn 
            340                 345                 350         


Gly Phe Phe Asp Ser Glu Leu His Thr Thr Glu Asp Lys Phe Asn Ile 
        355                 360                 365             


Thr Ser Arg Tyr Leu Gly Gly Asp Lys Ser Asn Arg Leu Ser Lys Leu 
    370                 375                 380                 


Tyr Lys Ile Trp Lys Lys Glu Gly Val Asp Cys Glu Glu Gly Ile Gln 
385                 390                 395                 400 


Gln Phe Cys Glu Ala Val Lys Asp Lys Met Gly Gln Ile Pro Ile Arg 
                405                 410                 415     


Asn Val Leu Lys Tyr Leu Trp Gln Phe Arg Glu Thr Val Ser Ala Glu 
            420                 425                 430         


Asp Phe Glu Ala Ala Ala Lys Ala Asn His Leu Glu Glu Lys Ile Ser 
        435                 440                 445             


Arg Val Lys Ala His Pro Ile Val Ile Ser Asn Arg Tyr Trp Ala Phe 
    450                 455                 460                 


Gly Thr Ser Ala Leu Val Gly Asn Ile Met Pro Ala Asp Lys Arg His 
465                 470                 475                 480 


Gln Gly Glu Tyr Ala Gly Gln Asn Phe Lys Met Trp Leu Arg Ala Glu 
                485                 490                 495     


Leu His Tyr Asp Gly Lys Lys Ala Lys Ala His Leu Pro Phe Tyr Asn 
            500                 505                 510         


Ala Arg Phe Phe Glu Glu Val Tyr Cys Tyr His Pro Ser Val Ala Glu 
        515                 520                 525             


Ile Thr Pro Phe Lys Thr Lys Gln Phe Gly Cys Glu Ile Gly Lys Asp 
    530                 535                 540                 


Ile Pro Asp Tyr Val Ser Val Ala Leu Lys Asp Asn Pro Tyr Lys Lys 
545                 550                 555                 560 


Ala Thr Lys Arg Ile Leu Arg Ala Ile Tyr Asn Pro Val Ala Asn Thr 
                565                 570                 575     


Thr Arg Val Asp Lys Thr Thr Asn Cys Ser Phe Met Ile Lys Arg Glu 
            580                 585                 590         


Asn Asp Glu Tyr Lys Leu Val Ile Asn Arg Lys Ile Ser Arg Asp Arg 
        595                 600                 605             


Pro Lys Arg Ile Glu Val Gly Arg Thr Ile Met Gly Tyr Asp Arg Asn 
    610                 615                 620                 


Gln Thr Ala Ser Asp Thr Tyr Trp Ile Gly Arg Leu Val Pro Pro Gly 
625                 630                 635                 640 


Thr Arg Gly Ala Tyr Arg Ile Gly Glu Trp Ser Val Gln Tyr Ile Lys 
                645                 650                 655     


Ser Gly Pro Val Leu Ser Ser Thr Gln Gly Val Asn Asn Ser Thr Thr 
            660                 665                 670         


Asp Gln Leu Val Tyr Asn Gly Met Pro Ser Ser Ser Glu Arg Phe Lys 
        675                 680                 685             


Ala Trp Lys Lys Ala Arg Met Ala Phe Ile Arg Lys Leu Ile Arg Gln 
    690                 695                 700                 


Leu Asn Asp Glu Gly Leu Glu Ser Lys Gly Gln Asp Tyr Ile Pro Glu 
705                 710                 715                 720 


Asn Pro Ser Ser Phe Asp Val Arg Gly Glu Thr Leu Tyr Val Phe Asn 
                725                 730                 735     


Ser Asn Tyr Leu Lys Ala Leu Val Ser Lys His Arg Lys Ala Lys Lys 
            740                 745                 750         


Pro Val Glu Gly Ile Leu Asp Glu Ile Glu Ala Trp Thr Ser Lys Asp 
        755                 760                 765             


Lys Asp Ser Cys Ser Leu Met Arg Leu Ser Ser Leu Ser Asp Ala Ser 
    770                 775                 780                 


Met Gln Gly Ile Ala Ser Leu Lys Ser Leu Ile Asn Ser Tyr Phe Asn 
785                 790                 795                 800 


Lys Asn Gly Cys Lys Thr Ile Glu Asp Lys Glu Lys Phe Asn Pro Val 
                805                 810                 815     


Leu Tyr Ala Lys Leu Val Glu Val Glu Gln Arg Arg Thr Asn Lys Arg 
            820                 825                 830         


Ser Glu Lys Val Gly Arg Ile Ala Gly Ser Leu Glu Gln Leu Ala Leu 
        835                 840                 845             


Leu Asn Gly Val Glu Val Val Ile Gly Glu Ala Asp Leu Gly Glu Val 
    850                 855                 860                 


Glu Lys Gly Lys Ser Lys Lys Gln Asn Ser Arg Asn Met Asp Trp Cys 
865                 870                 875                 880 


Ala Lys Gln Val Ala Gln Arg Leu Glu Tyr Lys Leu Ala Phe His Gly 
                885                 890                 895     


Ile Gly Tyr Phe Gly Val Asn Pro Met Tyr Thr Ser His Gln Asp Pro 
            900                 905                 910         


Phe Glu His Arg Arg Val Ala Asp His Ile Val Met Arg Ala Arg Phe 
        915                 920                 925             


Glu Glu Val Asn Val Glu Asn Ile Ala Glu Trp His Val Arg Asn Phe 
    930                 935                 940                 


Ser Asn Tyr Leu Arg Ala Asp Ser Gly Thr Gly Leu Tyr Tyr Lys Gln 
945                 950                 955                 960 


Ala Thr Met Asp Phe Leu Lys His Tyr Gly Leu Glu Glu His Ala Glu 
                965                 970                 975     


Gly Leu Glu Asn Lys Lys Ile Lys Phe Tyr Asp Phe Arg Lys Ile Leu 
            980                 985                 990         


Glu Asp Lys Asn Leu Thr Ser Val  Ile Ile Pro Lys Arg  Gly Gly Arg 
        995                 1000                 1005             


Ile Tyr  Met Ala Thr Asn Pro  Val Thr Ser Asp Ser  Thr Pro Ile 
    1010                 1015                 1020             


Thr Tyr  Ala Gly Lys Thr Tyr  Asn Arg Cys Asn Ala  Asp Glu Val 
    1025                 1030                 1035             


Ala Ala  Ala Asn Ile Val Ile  Ser Val Leu Ala Pro  Arg Ser Lys 
    1040                 1045                 1050             


Lys Asn  Arg Glu Gln Asp Asp  Ile Pro Leu Ile Thr  Lys Lys Ala 
    1055                 1060                 1065             


Glu Ser  Lys Ser Pro Pro Lys  Asp Arg Lys Arg Ser  Lys Thr Ser 
    1070                 1075                 1080             


Gln Leu  Pro Gln Lys Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly 
    1085                 1090                 1095             


Gln Ala  Lys Lys Lys Lys Ser  Gly Gly Ser Ser Gly  Gly Ser Ser 
    1100                 1105                 1110             


Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1115                 1120                 1125             


Ser Gly  Gly Ser Ser Gly Gly  Ser Thr Leu Asn Ile  Glu Asp Glu 
    1130                 1135                 1140             


Tyr Arg  Leu His Glu Thr Ser  Lys Glu Pro Asp Val  Ser Leu Gly 
    1145                 1150                 1155             


Ser Thr  Trp Leu Ser Asp Phe  Pro Gln Ala Trp Ala  Glu Thr Gly 
    1160                 1165                 1170             


Gly Met  Gly Leu Ala Val Arg  Gln Ala Pro Leu Ile  Ile Pro Leu 
    1175                 1180                 1185             


Lys Ala  Thr Ser Thr Pro Val  Ser Ile Lys Gln Tyr  Pro Met Ser 
    1190                 1195                 1200             


Gln Glu  Ala Arg Leu Gly Ile  Lys Pro His Ile Gln  Arg Leu Leu 
    1205                 1210                 1215             


Asp Gln  Gly Ile Leu Val Pro  Cys Gln Ser Pro Trp  Asn Thr Pro 
    1220                 1225                 1230             


Leu Leu  Pro Val Lys Lys Pro  Gly Thr Asn Asp Tyr  Arg Pro Val 
    1235                 1240                 1245             


Gln Asp  Leu Arg Glu Val Asn  Lys Arg Val Glu Asp  Ile His Pro 
    1250                 1255                 1260             


Thr Val  Pro Asn Pro Tyr Asn  Leu Leu Ser Gly Leu  Pro Pro Ser 
    1265                 1270                 1275             


His Gln  Trp Tyr Thr Val Leu  Asp Leu Lys Asp Ala  Phe Phe Cys 
    1280                 1285                 1290             


Leu Arg  Leu His Pro Thr Ser  Gln Pro Leu Phe Ala  Phe Glu Trp 
    1295                 1300                 1305             


Arg Asp  Pro Glu Met Gly Ile  Ser Gly Gln Leu Thr  Trp Thr Arg 
    1310                 1315                 1320             


Leu Pro  Gln Gly Phe Lys Asn  Ser Pro Thr Leu Phe  Asn Glu Ala 
    1325                 1330                 1335             


Leu His  Arg Asp Leu Ala Asp  Phe Arg Ile Gln His  Pro Asp Leu 
    1340                 1345                 1350             


Ile Leu  Leu Gln Tyr Val Asp  Asp Leu Leu Leu Ala  Ala Thr Ser 
    1355                 1360                 1365             


Glu Leu  Asp Cys Gln Gln Gly  Thr Arg Ala Leu Leu  Gln Thr Leu 
    1370                 1375                 1380             


Gly Asn  Leu Gly Tyr Arg Ala  Ser Ala Lys Lys Ala  Gln Ile Cys 
    1385                 1390                 1395             


Gln Lys  Gln Val Lys Tyr Leu  Gly Tyr Leu Leu Lys  Glu Gly Gln 
    1400                 1405                 1410             


Arg Trp  Leu Thr Glu Ala Arg  Lys Glu Thr Val Met  Gly Gln Pro 
    1415                 1420                 1425             


Thr Pro  Lys Thr Pro Arg Gln  Leu Arg Glu Phe Leu  Gly Lys Ala 
    1430                 1435                 1440             


Gly Phe  Cys Arg Leu Phe Ile  Pro Gly Phe Ala Glu  Met Ala Ala 
    1445                 1450                 1455             


Pro Leu  Tyr Pro Leu Thr Lys  Pro Gly Thr Leu Phe  Asn Trp Gly 
    1460                 1465                 1470             


Pro Asp  Gln Gln Lys Ala Tyr  Gln Glu Ile Lys Gln  Ala Leu Leu 
    1475                 1480                 1485             


Thr Ala  Pro Ala Leu Gly Leu  Pro Asp Leu Thr Lys  Pro Phe Glu 
    1490                 1495                 1500             


Leu Phe  Val Asp Glu Lys Gln  Gly Tyr Ala Lys Gly  Val Leu Thr 
    1505                 1510                 1515             


Gln Lys  Leu Gly Pro Trp Arg  Arg Pro Val Ala Tyr  Leu Ser Lys 
    1520                 1525                 1530             


Lys Leu  Asp Pro Val Ala Ala  Gly Trp Pro Pro Cys  Leu Arg Met 
    1535                 1540                 1545             


Val Ala  Ala Ile Ala Val Leu  Thr Lys Asp Ala Gly  Lys Leu Thr 
    1550                 1555                 1560             


Met Gly  Gln Pro Leu Val Ile  Leu Ala Pro His Ala  Val Glu Ala 
    1565                 1570                 1575             


Leu Val  Lys Gln Pro Pro Asp  Arg Trp Leu Ser Asn  Ala Arg Met 
    1580                 1585                 1590             


Thr His  Tyr Gln Ala Leu Leu  Leu Asp Thr Asp Arg  Val Gln Phe 
    1595                 1600                 1605             


Gly Pro  Val Val Ala Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro 
    1610                 1615                 1620             


Glu Glu  Gly Leu Gln His Asn  Cys Leu Asp Ile Leu  Ala Glu Ala 
    1625                 1630                 1635             


His Gly  Thr Arg Pro Asp Leu  Thr Asp Gln Pro Leu  Pro Asp Ala 
    1640                 1645                 1650             


Asp His  Thr Trp Tyr Thr Asp  Gly Ser Ser Leu Leu  Gln Glu Gly 
    1655                 1660                 1665             


Gln Arg  Lys Ala Gly Ala Ala  Val Thr Thr Glu Thr  Glu Val Ile 
    1670                 1675                 1680             


Trp Ala  Lys Ala Leu Pro Ala  Gly Thr Ser Ala Gln  Arg Ala Glu 
    1685                 1690                 1695             


Leu Ile  Ala Leu Thr Gln Ala  Leu Lys Met Ala Glu  Gly Lys Lys 
    1700                 1705                 1710             


Leu Asn  Val Tyr Thr Asp Ser  Arg Tyr Ala Phe Ala  Thr Ala His 
    1715                 1720                 1725             


Ile His  Gly Glu Ile Tyr Arg  Arg Arg Gly Trp Leu  Thr Ser Glu 
    1730                 1735                 1740             


Gly Lys  Glu Ile Lys Asn Lys  Asp Glu Ile Leu Ala  Leu Leu Lys 
    1745                 1750                 1755             


Ala Leu  Phe Leu Pro Lys Arg  Leu Ser Ile Ile His  Cys Pro Gly 
    1760                 1765                 1770             


His Gln  Lys Gly His Ser Ala  Glu Ala Arg Gly Asn  Arg Met Ala 
    1775                 1780                 1785             


Asp Gln  Ala Ala Arg Lys Ala  Ala Ile Thr Glu Thr  Pro Asp Thr 
    1790                 1795                 1800             


Ser Thr  Leu Leu Ile Glu Asn  Ser Ser Pro Met Lys  Arg Thr Ala 
    1805                 1810                 1815             


Asp Gly  Ser Glu Phe Glu Ser  Pro Lys Lys Lys Arg  Lys Val 
    1820                 1825                 1830         


<210>  53
<211>  1818
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Met Ala Ser Ile Ser Arg Pro Tyr 
                725                 730                 735     


Gly Thr Lys Leu Arg Pro Asp Ala Arg Lys Lys Glu Met Leu Asp Lys 
            740                 745                 750         


Phe Phe Asn Thr Leu Thr Lys Gly Gln Arg Val Phe Ala Asp Leu Ala 
        755                 760                 765             


Leu Cys Ile Tyr Gly Ser Leu Thr Leu Glu Met Ala Lys Ser Leu Glu 
    770                 775                 780                 


Pro Glu Ser Asp Ser Glu Leu Val Cys Ala Ile Gly Trp Phe Arg Leu 
785                 790                 795                 800 


Val Asp Lys Thr Ile Trp Ser Lys Asp Gly Ile Lys Gln Glu Asn Leu 
                805                 810                 815     


Val Lys Gln Tyr Glu Ala Tyr Ser Gly Lys Glu Ala Ser Glu Val Val 
            820                 825                 830         


Lys Thr Tyr Leu Asn Ser Pro Ser Ser Asp Lys Tyr Val Trp Ile Asp 
        835                 840                 845             


Cys Arg Gln Lys Phe Leu Arg Phe Gln Arg Glu Leu Gly Thr Arg Asn 
    850                 855                 860                 


Leu Ser Glu Asp Phe Glu Cys Met Leu Phe Glu Gln Tyr Ile Arg Leu 
865                 870                 875                 880 


Thr Lys Gly Glu Ile Glu Gly Tyr Ala Ala Ile Ser Asn Met Phe Gly 
                885                 890                 895     


Asn Gly Glu Lys Glu Asp Arg Ser Lys Lys Arg Met Tyr Ala Thr Arg 
            900                 905                 910         


Met Lys Asp Trp Leu Glu Ala Asn Glu Asn Ile Thr Trp Glu Gln Tyr 
        915                 920                 925             


Arg Glu Ala Leu Lys Asn Gln Leu Asn Ala Lys Asn Leu Glu Gln Val 
    930                 935                 940                 


Val Ala Asn Tyr Lys Gly Asn Ala Gly Gly Ala Asp Pro Phe Phe Lys 
945                 950                 955                 960 


Tyr Ser Phe Ser Lys Glu Gly Met Val Ser Lys Lys Glu His Ala Gln 
                965                 970                 975     


Gln Leu Asp Lys Phe Lys Thr Val Leu Lys Asn Lys Ala Arg Asp Leu 
            980                 985                 990         


Asn Phe Pro Asn Lys Glu Lys Leu  Lys Gln Tyr Leu Glu  Ala Glu Ile 
        995                 1000                 1005             


Gly Ile  Pro Val Asp Ala Asn  Val Tyr Ser Gln Met  Phe Ser Asn 
    1010                 1015                 1020             


Gly Val  Ser Glu Val Gln Pro  Lys Thr Thr Arg Asn  Met Ser Phe 
    1025                 1030                 1035             


Ser Asn  Glu Lys Leu Asp Leu  Leu Thr Glu Leu Lys  Asp Leu Asn 
    1040                 1045                 1050             


Lys Gly  Asp Gly Phe Glu Tyr  Ala Arg Glu Val Leu  Asn Gly Phe 
    1055                 1060                 1065             


Phe Asp  Ser Glu Leu His Thr  Thr Glu Asp Lys Phe  Asn Ile Thr 
    1070                 1075                 1080             


Ser Arg  Tyr Leu Gly Gly Asp  Lys Ser Asn Arg Leu  Ser Lys Leu 
    1085                 1090                 1095             


Tyr Lys  Ile Trp Lys Lys Glu  Gly Val Asp Cys Glu  Glu Gly Ile 
    1100                 1105                 1110             


Gln Gln  Phe Cys Glu Ala Val  Lys Asp Lys Met Gly  Gln Ile Pro 
    1115                 1120                 1125             


Ile Arg  Asn Val Leu Lys Tyr  Leu Trp Gln Phe Arg  Glu Thr Val 
    1130                 1135                 1140             


Ser Ala  Glu Asp Phe Glu Ala  Ala Ala Lys Ala Asn  His Leu Glu 
    1145                 1150                 1155             


Glu Lys  Ile Ser Arg Val Lys  Ala His Pro Ile Val  Ile Ser Asn 
    1160                 1165                 1170             


Arg Tyr  Trp Ala Phe Gly Thr  Ser Ala Leu Val Gly  Asn Ile Met 
    1175                 1180                 1185             


Pro Ala  Asp Lys Arg His Gln  Gly Glu Tyr Ala Gly  Gln Asn Phe 
    1190                 1195                 1200             


Lys Met  Trp Leu Arg Ala Glu  Leu His Tyr Asp Gly  Lys Lys Ala 
    1205                 1210                 1215             


Lys Ala  His Leu Pro Phe Tyr  Asn Ala Arg Phe Phe  Glu Glu Val 
    1220                 1225                 1230             


Tyr Cys  Tyr His Pro Ser Val  Ala Glu Ile Thr Pro  Phe Lys Thr 
    1235                 1240                 1245             


Lys Gln  Phe Gly Cys Glu Ile  Gly Lys Asp Ile Pro  Asp Tyr Val 
    1250                 1255                 1260             


Ser Val  Ala Leu Lys Asp Asn  Pro Tyr Lys Lys Ala  Thr Lys Arg 
    1265                 1270                 1275             


Ile Leu  Arg Ala Ile Tyr Asn  Pro Val Ala Asn Thr  Thr Arg Val 
    1280                 1285                 1290             


Asp Lys  Thr Thr Asn Cys Ser  Phe Met Ile Lys Arg  Glu Asn Asp 
    1295                 1300                 1305             


Glu Tyr  Lys Leu Val Ile Asn  Arg Lys Ile Ser Arg  Asp Arg Pro 
    1310                 1315                 1320             


Lys Arg  Ile Glu Val Gly Arg  Thr Ile Met Gly Tyr  Asp Arg Asn 
    1325                 1330                 1335             


Gln Thr  Ala Ser Asp Thr Tyr  Trp Ile Gly Arg Leu  Val Pro Pro 
    1340                 1345                 1350             


Gly Thr  Arg Gly Ala Tyr Arg  Ile Gly Glu Trp Ser  Val Gln Tyr 
    1355                 1360                 1365             


Ile Lys  Ser Gly Pro Val Leu  Ser Ser Thr Gln Gly  Val Asn Asn 
    1370                 1375                 1380             


Ser Thr  Thr Asp Gln Leu Val  Tyr Asn Gly Met Pro  Ser Ser Ser 
    1385                 1390                 1395             


Glu Arg  Phe Lys Ala Trp Lys  Lys Ala Arg Met Ala  Phe Ile Arg 
    1400                 1405                 1410             


Lys Leu  Ile Arg Gln Leu Asn  Asp Glu Gly Leu Glu  Ser Lys Gly 
    1415                 1420                 1425             


Gln Asp  Tyr Ile Pro Glu Asn  Pro Ser Ser Phe Asp  Val Arg Gly 
    1430                 1435                 1440             


Glu Thr  Leu Tyr Val Phe Asn  Ser Asn Tyr Leu Lys  Ala Leu Val 
    1445                 1450                 1455             


Ser Lys  His Arg Lys Ala Lys  Lys Pro Val Glu Gly  Ile Leu Asp 
    1460                 1465                 1470             


Glu Ile  Glu Ala Trp Thr Ser  Lys Asp Lys Asp Ser  Cys Ser Leu 
    1475                 1480                 1485             


Met Arg  Leu Ser Ser Leu Ser  Asp Ala Ser Met Gln  Gly Ile Ala 
    1490                 1495                 1500             


Ser Leu  Lys Ser Leu Ile Asn  Ser Tyr Phe Asn Lys  Asn Gly Cys 
    1505                 1510                 1515             


Lys Thr  Ile Glu Asp Lys Glu  Lys Phe Asn Pro Val  Leu Tyr Ala 
    1520                 1525                 1530             


Lys Leu  Val Glu Val Glu Gln  Arg Arg Thr Asn Lys  Arg Ser Glu 
    1535                 1540                 1545             


Lys Val  Gly Arg Ile Ala Gly  Ser Leu Glu Gln Leu  Ala Leu Leu 
    1550                 1555                 1560             


Asn Gly  Val Glu Val Val Ile  Gly Glu Ala Asp Leu  Gly Glu Val 
    1565                 1570                 1575             


Glu Lys  Gly Lys Ser Lys Lys  Gln Asn Ser Arg Asn  Met Asp Trp 
    1580                 1585                 1590             


Cys Ala  Lys Gln Val Ala Gln  Arg Leu Glu Tyr Lys  Leu Ala Phe 
    1595                 1600                 1605             


His Gly  Ile Gly Tyr Phe Gly  Val Asn Pro Met Tyr  Thr Ser His 
    1610                 1615                 1620             


Gln Asp  Pro Phe Glu His Arg  Arg Val Ala Asp His  Ile Val Met 
    1625                 1630                 1635             


Arg Ala  Arg Phe Glu Glu Val  Asn Val Glu Asn Ile  Ala Glu Trp 
    1640                 1645                 1650             


His Val  Arg Asn Phe Ser Asn  Tyr Leu Arg Ala Asp  Ser Gly Thr 
    1655                 1660                 1665             


Gly Leu  Tyr Tyr Lys Gln Ala  Thr Met Asp Phe Leu  Lys His Tyr 
    1670                 1675                 1680             


Gly Leu  Glu Glu His Ala Glu  Gly Leu Glu Asn Lys  Lys Ile Lys 
    1685                 1690                 1695             


Phe Tyr  Asp Phe Arg Lys Ile  Leu Glu Asp Lys Asn  Leu Thr Ser 
    1700                 1705                 1710             


Val Ile  Ile Pro Lys Arg Gly  Gly Arg Ile Tyr Met  Ala Thr Asn 
    1715                 1720                 1725             


Pro Val  Thr Ser Asp Ser Thr  Pro Ile Thr Tyr Ala  Gly Lys Thr 
    1730                 1735                 1740             


Tyr Asn  Arg Cys Asn Ala Asp  Glu Val Ala Ala Ala  Asn Ile Val 
    1745                 1750                 1755             


Ile Ser  Val Leu Ala Pro Arg  Ser Lys Lys Asn Arg  Glu Gln Asp 
    1760                 1765                 1770             


Asp Ile  Pro Leu Ile Thr Lys  Lys Ala Glu Ser Lys  Ser Pro Pro 
    1775                 1780                 1785             


Lys Asp  Arg Lys Arg Ser Lys  Thr Ser Gln Leu Pro  Gln Lys Lys 
    1790                 1795                 1800             


Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1805                 1810                 1815             


<210>  54
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcgagg cauggauuau agccgaaggc cccagcuuug ccuuguucua gcaguuccac      120

uccugggcag cccgaga                                                     137


<210>  55
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcgagg cauggauuau agccgaaggc cccagcuuug ccuuguu                    107


<210>  56
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
agaaauccgu cuuucauuga cgggggaagu gguuggucag caugcacccc cauaaggggg       60

cagcuacuuu gggaaguggu ugcgaggcau ggauuauagc cgaaggc                    107


<210>  57
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcgagg cauggauuau agccgaaggc                                        90


<210>  58
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugagcgg ucagcaugga uuauagccga aggc                                   94


<210>  59
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguuggcaug gauuauagcc gaaggc                                            86


<210>  60
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
agacaugugu ccucagugac acgggaagug guuggucagc au                          42


<210>  61
<211>  95
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
agacaugugu ccucagugac acgggaagug guuggucagc auugauucca gcuacucugg       60

gaagugguug cagugcaugg auuauagccg aaggc                                  95


<210>  62
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgccagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguuaga aauccgucuu      120

ucauugacgg gacgcuacua uagcugcac                                        149


<210>  63
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcuuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggccaaga aauccgucuu      120

ucauugacgg gacgcuacua uagcugcac                                        149


<210>  64
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc cacacauucu caagugcaga aauccgucuu      120

ucauugacgg gacgcuacua uagcugcac                                        149


<210>  65
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
gattccagct actttgggaa gtggttggtc agcatggatt atagccgaag gccccag          57


<210>  66
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
ctaaggtcga tgaaaccctt caccaaccag tcgtacctaa tatcggcttc cggggtc          57


<210>  67
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguuggucag cauggauuau agccgaaggc                                        90


<210>  68
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguugcgagu caagggcagc augcugggcc cgucccacua caggccaaug ugaccgucag      120

ucuccuuccu gaaggac                                                     137


<210>  69
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguugcgagu caagggcagc augcugggcc cgucccacua caggcca                    107


<210>  70
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
agaaauccgu cuuucauuga cgggagccag uguugcuagu caagcacccc cauaaggggg       60

uuccuucuuu gagccagugu ugcgagucaa gggcagcaug cugggcc                    107


<210>  71
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguugcgagu caagggcagc augcugggcc                                        90


<210>  72
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguugagcgc uagucaaggg cagcaugcug ggcc                                   94


<210>  73
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguugucaag ggcagcaugc ugggcc                                            86


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
gggaagtggt tggtcagcat                                                   20


<210>  75
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguuggucag cauggauuau agccgaaggc                                        90


<210>  76
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcgagg cauggauuau agccgaaggc                                        90


<210>  77
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugagcgg ucagcaugga uuauagccga aggc                                   94


<210>  78
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguuggcaug gauuauagcc gaaggc                                            86


<210>  79
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
agaaauccgu cuuucauuga cgggggaagu gguuggucag caugcacccc cauaaggggg       60

cagcuacuuu gggaaguggu ugcgaggcau ggauuauagc cgaaggc                    107


<210>  80
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcgagg cauggauuau agccgaaggc                                        90


<210>  81
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uuuaauccuc       60

caccacgagu ggugacaacc ccaagcagcc cacacauuuu caagugcccc caggaugcgu      120

ggagggaggg gucugug                                                     137


<210>  82
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uuuaauccuc       60

caccacgagu ggugacaacc ccaagcagcc cacacauuuu caagugc                    107


<210>  83
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
agaaauccgu cuuucauuga cggaauccuc caccagucau ggugcacccc cauaaggggg       60

agauaccuuu aauccuccac cacgaguggu gacaacccca agcagcc                    107


<210>  84
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uuuaauccuc       60

caccacgagu ggugacaacc ccaagcagcc                                        90


<210>  85
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uuuaauccuc       60

caccaagcgg ucauggugac aaccccaagc agcc                                   94


<210>  86
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uuuaauccuc       60

caccauggug acaaccccaa gcagcc                                            86


<210>  87
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcgagg cauggauuau agccgaaggc                                        90


<210>  88
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
ugggaagugg uuggucagca gttttagagc tagaaatagc aagttaaaat aaggctagtc       60

cgttatcaac ttgaaaaagt ggcaccgagt cggtgc                                 96


<210>  89
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
ggcuauaauc caugcaagug accaaccac                                         29


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
gggaagtggt tgcagtgcat                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
gagccagtgt tggatctcaa                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
ttaaactctc caacctccag                                                   20


<210>  93
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93
uaauuucuac uguuguagau                                                   20


<210>  94
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
agaaaugcau gguucucaug c                                                 21


<210>  95
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccacgagc caggcucauc cagcuuccca aacaaagccc ccaagaaggg ggggcacuca      120

ggacucucuc caagaga                                                     137


<210>  96
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uuuuuaaacu       60

cuccacgagc caggcucauc cagcuuccca aacaaagccc ccaagaa                    107


<210>  97
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97
agaaauccgu cuuucauuga cgguuaaacu cuccauggac caggcacccc cauaaggggg       60

aaaagacuuu uuaaacucuc cacgagccag gcucauccag cuuccca                    107


<210>  98
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uguuuaaacu       60

cuccacgagc caggcucauc cagcuuccca                                        90


<210>  99
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uguuuaaacu       60

cuccaagcgu ggaccaggcu cauccagcuu ccca                                   94


<210>  100
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uguuuaaacu       60

cuccaccagg cucauccagc uuccca                                            86


<210>  101
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101
aaaauuaccu aguaauuagg u                                                 21


<210>  102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102
ggauuucuac uuuuguagau                                                   20


<210>  103
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103
aaauuucuac uuuuguagau                                                   20


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104
cgcgcccacg cggggcgcga c                                                 21


<210>  105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105
uaauuucuac ucuuguagau                                                   20


<210>  106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106
gaauuucuac uauuguagau                                                   20


<210>  107
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107
gaaucucuac ucuuuguaga u                                                 21


<210>  108
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108
uaauuucuac uuuguagau                                                    19


<210>  109
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109
aaauuucuac uguuuguaga u                                                 21


<210>  110
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110
agaaauccgu cuuucauuga cggguagccu cucccgcucu ggu                         43


<210>  111
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111
gaauuucuac uuuuguagau                                                   20


<210>  112
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
agaaauccgu cuuucauuga cgggggaagu gguuggucag cau                         43


<210>  113
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113
uaauuucuac uaaguguaga u                                                 21


<210>  114
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114
agaaauccgu cuuucauuga cgggagccag uguugcuagu caa                         43


<210>  115
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115
uaauuucuac uauuguagau                                                   20


<210>  116
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116
agaaauccgu cuuucauuga cggaauccuc caccagucau ggu                         43


<210>  117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117
uaauuucuac uucgguagau                                                   20


<210>  118
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cag                         43


<210>  119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119
uaauuucuac uauuguagau                                                   20


<210>  120
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  121
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  122
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  123
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc                                        90


<210>  124
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguu                    107


<210>  125
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguucua gcaguuccac      120

uccugggcag cccgaga                                                     137


<210>  126
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc agaaauccgu cuuucauuga cgggcacacg      120

acgauguaau cgc                                                         133


<210>  127
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  127
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguuaga aauccgucuu      120

ucauugacgg gcacacgacg auguaaucgc                                       150


<210>  128
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguucua gcaguuccac      120

uccugggcag cccgagaaga aauccgucuu ucauugacgg gcacacgacg auguaaucgc      180


<210>  129
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129
cagcuacuau gggaaguggu ugcagugcau ggauuauagc cgaaggcaga aauccgucuu       60

ucauugacgg gggaaguggu uggucagcau                                        90


<210>  130
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130
cagcuacuau gggaaguggu ugcagugcau ggauuauagc cgaaggcccc agcuuugccu       60

uguuagaaau ccgucuuuca uugacggggg aagugguugg ucagcau                    107


<210>  131
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131
cagcuacuau gggaaguggu ugcagugcau ggauuauagc cgaaggcccc agcuuugccu       60

uguucuagca guuccacucc ugggcagccc gagaagaaau ccgucuuuca uugacggggg      120

aagugguugg ucagcau                                                     137


<210>  132
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgccagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc agaaauccgu cuuucauuga cgggggaagu      120

gguuggucag cau                                                         133


<210>  133
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgccagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguuaga aauccgucuu      120

ucauugacgg gggaaguggu uggucagcau                                       150


<210>  134
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgccagcuac uaugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguucua gcaguuccac      120

uccugggcag cccgagaaga aauccgucuu ucauugacgg gggaaguggu uggucagcau      180


<210>  135
<211>  139
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcugauucc agcuacuaug       60

ggaagugguu gcagugcaug gauuauagcc gaaggcagaa auccgucuuu cauugacggg      120

ggaagugguu ggucagcau                                                   139


<210>  136
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcugauucc agcuacuaug       60

ggaagugguu gcagugcaug gauuauagcc gaaggcccca gcuuugccuu guuagaaauc      120

cgucuuucau ugacggggga agugguuggu cagcau                                156


<210>  137
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcugauucc agcuacuaug       60

ggaagugguu gcagugcaug gauuauagcc gaaggcccca gcuuugccuu guucuagcag      120

uuccacuccu gggcagcccg agaagaaauc cgucuuucau ugacggggga agugguuggu      180

cagcau                                                                 186


<210>  138
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc                                        90


<210>  139
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggcca                    107


<210>  140
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggccaaug ugaccgucag      120

ucuccuuccu gaaggac                                                     137


<210>  141
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc agaaauccgu cuuucauuga cgggcacacg      120

acgauguaau cgc                                                         133


<210>  142
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggccaaga aauccgucuu      120

ucauugacgg gcacacgacg auguaaucgc                                       150


<210>  143
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggccaaug ugaccgucag      120

ucuccuuccu gaaggacaga aauccgucuu ucauugacgg gcacacgacg auguaaucgc      180


<210>  144
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
uuccuucuau gagccagugu uggaucucaa gggcagcaug cugggccaga aauccgucuu       60

ucauugacgg gagccagugu ugcuagucaa                                        90


<210>  145
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
uuccuucuau gagccagugu uggaucucaa gggcagcaug cugggcccgu cccacuacag       60

gccaagaaau ccgucuuuca uugacgggag ccaguguugc uagucaa                    107


<210>  146
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
uuccuucuau gagccagugu uggaucucaa gggcagcaug cugggcccgu cccacuacag       60

gccaauguga ccgucagucu ccuuccugaa ggacagaaau ccgucuuuca uugacgggag      120

ccaguguugc uagucaa                                                     137


<210>  147
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcuuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc agaaauccgu cuuucauuga cgggagccag      120

uguugcuagu caa                                                         133


<210>  148
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcuuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggccaaga aauccgucuu      120

ucauugacgg gagccagugu ugcuagucaa                                       150


<210>  149
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcuuccuuc uaugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggccaaug ugaccgucag      120

ucuccuuccu gaaggacaga aauccgucuu ucauugacgg gagccagugu ugcuagucaa      180


<210>  150
<211>  139
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaaagcuu uccuucuaug       60

agccaguguu ggaucucaag ggcagcaugc ugggccagaa auccgucuuu cauugacggg      120

agccaguguu gcuagucaa                                                   139


<210>  151
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaaagcuu uccuucuaug       60

agccaguguu ggaucucaag ggcagcaugc ugggcccguc ccacuacagg ccaagaaauc      120

cgucuuucau ugacgggagc caguguugcu agucaa                                156


<210>  152
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaaagcuu uccuucuaug       60

agccaguguu ggaucucaag ggcagcaugc ugggcccguc ccacuacagg ccaaugugac      120

cgucagucuc cuuccugaag gacagaaauc cgucuuucau ugacgggagc caguguugcu      180

agucaa                                                                 186


<210>  153
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc                                        90


<210>  154
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc cacacauucu caagugc                    107


<210>  155
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  155
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc cacacauucu caagugcccc caggaugcgu      120

ggagggaggg gucugug                                                     137


<210>  156
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  156
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc agaaauccgu cuuucauuga cgggcacacg      120

acgauguaau cgc                                                         133


<210>  157
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc cacacauucu caagugcaga aauccgucuu      120

ucauugacgg gcacacgacg auguaaucgc                                       150


<210>  158
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158
agaaauccgu cuuucauuga cggaauccuc caccagucau gguagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc cacacauucu caagugcccc caggaugcgu      120

ggagggaggg gucugugaga aauccgucuu ucauugacgg gcacacgacg auguaaucgc      180


<210>  159
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  159
agauaccuau aauccuccac cacaguuggu gacaacccca agcagccaga aauccgucuu       60

ucauugacgg aauccuccac cagucauggu                                        90


<210>  160
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  160
agauaccuau aauccuccac cacaguuggu gacaacccca agcagcccac acauucucaa       60

gugcagaaau ccgucuuuca uugacggaau ccuccaccag ucauggu                    107


<210>  161
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  161
agauaccuau aauccuccac cacaguuggu gacaacccca agcagcccac acauucucaa       60

gugcccccag gaugcgugga gggagggguc ugugagaaau ccgucuuuca uugacggaau      120

ccuccaccag ucauggu                                                     137


<210>  162
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  162
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc agaaauccgu cuuucauuga cggaauccuc      120

caccagucau ggu                                                         133


<210>  163
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  163
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc cacacauucu caagugcaga aauccgucuu      120

ucauugacgg aauccuccac cagucauggu                                       150


<210>  164
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  164
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcagauacc uauaauccuc       60

caccacaguu ggugacaacc ccaagcagcc cacacauucu caagugcccc caggaugcgu      120

ggagggaggg gucugugaga aauccgucuu ucauugacgg aauccuccac cagucauggu      180


<210>  165
<211>  139
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  165
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaauacua gauaccuaua       60

auccuccacc acaguuggug acaaccccaa gcagccagaa auccgucuuu cauugacgga      120

auccuccacc agucauggu                                                   139


<210>  166
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  166
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaauacua gauaccuaua       60

auccuccacc acaguuggug acaaccccaa gcagcccaca cauucucaag ugcagaaauc      120

cgucuuucau ugacggaauc cuccaccagu cauggu                                156


<210>  167
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  167
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaauacua gauaccuaua       60

auccuccacc acaguuggug acaaccccaa gcagcccaca cauucucaag ugcccccagg      120

augcguggag ggaggggucu gugagaaauc cgucuuucau ugacggaauc cuccaccagu      180

cauggu                                                                 186


<210>  168
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  168
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca                                        90


<210>  169
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  169
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaa                    107


<210>  170
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  170
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaaggg ggggcacuca      120

ggacucucuc caagaga                                                     137


<210>  171
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  171
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca agaaauccgu cuuucauuga cgggcacacg      120

acgauguaau cgc                                                         133


<210>  172
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  172
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaaaga aauccgucuu      120

ucauugacgg gcacacgacg auguaaucgc                                       150


<210>  173
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  173
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaaggg ggggcacuca      120

ggacucucuc caagagaaga aauccgucuu ucauugacgg gcacacgacg auguaaucgc      180


<210>  174
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  174
aaaagacuac uuaaacucuc caaccuccag gcucauccag cuucccaaga aauccgucuu       60

ucauugacgg uuaaacucuc cauggaccag                                        90


<210>  175
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  175
aaaagacuac uuaaacucuc caaccuccag gcucauccag cuucccaaac aaagccccca       60

agaaagaaau ccgucuuuca uugacgguua aacucuccau ggaccag                    107


<210>  176
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  176
aaaagacuac uuaaacucuc caaccuccag gcucauccag cuucccaaac aaagccccca       60

agaagggggg gcacucagga cucucuccaa gagaagaaau ccgucuuuca uugacgguua      120

aacucuccau ggaccag                                                     137


<210>  177
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  177
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca agaaauccgu cuuucauuga cgguuaaacu      120

cuccauggac cag                                                         133


<210>  178
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  178
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaaaga aauccgucuu      120

ucauugacgg uuaaacucuc cauggaccag                                       150


<210>  179
<211>  180
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  179
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaaaagac uacuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaaggg ggggcacuca      120

ggacucucuc caagagaaga aauccgucuu ucauugacgg uuaaacucuc cauggaccag      180


<210>  180
<211>  139
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  180
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaacacca aaagacuacu       60

uaaacucucc aaccuccagg cucauccagc uucccaagaa auccgucuuu cauugacggu      120

uaaacucucc auggaccag                                                   139


<210>  181
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  181
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaacacca aaagacuacu       60

uaaacucucc aaccuccagg cucauccagc uucccaaaca aagcccccaa gaaagaaauc      120

cgucuuucau ugacgguuaa acucuccaug gaccag                                156


<210>  182
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  182
agaaauccgu cuuucauuga cgggcacacg acgauguaau cgcaacacca aaagacuacu       60

uaaacucucc aaccuccagg cucauccagc uucccaaaca aagcccccaa gaaggggggg      120

cacucaggac ucucuccaag agaagaaauc cgucuuucau ugacgguuaa acucuccaug      180

gaccag                                                                 186


<210>  183
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  183
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcagug cauggauuau                                                   80


<210>  184
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  184
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcagug cauggauuau agccg                                             85


<210>  185
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  185
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcagug cauggauuau agccgaaggc                                        90


<210>  186
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  186
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguu                    107


<210>  187
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  187
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcagug cauggauuau agccgaaggc cccagcuuug ccuuguucua gcaguuccac      120

uccugggcag cccgaga                                                     137


<210>  188
<211>  70
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  188
agaaauccgu cuuucauuga cgggggaagu gguuggucag cauugcagug cauggauuau       60

agccgaaggc                                                              70


<210>  189
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  189
agaaauccgu cuuucauuga cgggggaagu gguuggucag caugggaagu gguugcagug       60

cauggauuau agccgaaggc                                                   80


<210>  190
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  190
agaaauccgu cuuucauuga cgggggaagu gguuggucag caucagcuac uuugggaagu       60

gguugcagug cauggauuau agccgaaggc                                        90


<210>  191
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  191
agaaauccgu cuuucauuga cgggggaagu gguuggucag caugugauga uuccagcuac       60

uuugggaagu gguugcagug cauggauuau agccgaaggc                            100


<210>  192
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  192
agaaauccgu cuuucauuga cgggggaagu gguuggucag caugguggga aaggugauga       60

uuccagcuac uuugggaagu gguugcagug cauggauuau agccgaaggc                 110


<210>  193
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  193
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguuggaucu caagggcagc                                                   80


<210>  194
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  194
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguuggaucu caagggcagc augcu                                             85


<210>  195
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  195
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguuggaucu caagggcagc augcugggcc                                        90


<210>  196
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  196
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggcca                    107


<210>  197
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  197
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguuggaucu caagggcagc augcugggcc cgucccacua caggccaaug ugaccgucag      120

ucuccuuccu gaaggac                                                     137


<210>  198
<211>  70
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  198
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauggaucu caagggcagc       60

augcugggcc                                                              70


<210>  199
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  199
agaaauccgu cuuucauuga cgggagccag uguugcuagu caagagccag uguuggaucu       60

caagggcagc augcugggcc                                                   80


<210>  200
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  200
agaaauccgu cuuucauuga cgggagccag uguugcuagu caauuccuuc uuugagccag       60

uguuggaucu caagggcagc augcugggcc                                        90


<210>  201
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  201
agaaauccgu cuuucauuga cgggagccag uguugcuagu caaauccaaa gcuuuccuuc       60

uuugagccag uguuggaucu caagggcagc augcugggcc                            100


<210>  202
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  202
agaaauccgu cuuucauuga cgggagccag uguugcuagu caaugaaguc gccauccaaa       60

gcuuuccuuc uuugagccag uguuggaucu caagggcagc augcugggcc                 110


<210>  203
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  203
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uucuuaaacu       60

cuccaaccuc caggcucauc                                                   80


<210>  204
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  204
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uucuuaaacu       60

cuccaaccuc caggcucauc cagcu                                             85


<210>  205
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  205
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uucuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca                                        90


<210>  206
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  206
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uucuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaa                    107


<210>  207
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  207
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uucuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca aacaaagccc ccaagaaggg ggggcacuca      120

ggacucucuc caagaga                                                     137


<210>  208
<211>  70
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  208
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagcaaccuc caggcucauc       60

cagcuuccca                                                              70


<210>  209
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  209
agaaauccgu cuuucauuga cgguuaaacu cuccauggac caguuaaacu cuccaaccuc       60

caggcucauc cagcuuccca                                                   80


<210>  210
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  210
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagaaaagac uucuuaaacu       60

cuccaaccuc caggcucauc cagcuuccca                                        90


<210>  211
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  211
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagagguaac accaaaagac       60

uucuuaaacu cuccaaccuc caggcucauc cagcuuccca                            100


<210>  212
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  212
agaaauccgu cuuucauuga cgguuaaacu cuccauggac cagccccauu accagguaac       60

accaaaagac uucuuaaacu cuccaaccuc caggcucauc cagcuuccca                 110


<210>  213
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  213
tccatgtctc gttatacgct gtggttcgcc aacaacacta gtactactga taaattaccc       60

cccaagtccc tcacctctcc aaagctgccc atactactac actagtttga cagctagctc      120

agtcctaggt ataatgctag c                                                141


<210>  214
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  214
tccatgtctc gttatacgct gtggttcgcc aacatatagt tcactactag catgctgccc       60

ttgactagca acactggctc aaagaaggaa agactactta tagttcttga cagctagctc      120

agtcctaggt ataatgctag c                                                141


<210>  215
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  215
tccatgtctc gttatacgct gtggttcgcc aacgcaggaa cgacactact agctggatga       60

gcctggtcca tggagagttt aaaaagtctt ttggactact ggaacgactt gacagctagc      120

tcagtcctag gtataatgct agc                                              143


<210>  216
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  216
agaaatccgt ctttcattga cggggagagg tgagggactt ggg                         43


<210>  217
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  217
agaaatccgt ctttcattga cgggagccag tgttgctagt caa                         43


<210>  218
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  218
agaaatccgt ctttcattga cggttaaact ctccatggac cag                         43


<210>  219
<211>  1812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  219

Met Lys Ile Glu Glu Gly Lys Gly His His His His His His Met Ser 
1               5                   10                  15      


Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu Arg Lys 
            20                  25                  30          


Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly Ser Ala 
        35                  40                  45              


Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr Pro Glu 
    50                  55                  60                  


Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp Ile Ala 
65                  70                  75                  80  


Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp Ser Leu 
                85                  90                  95      


Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu Glu Tyr 
            100                 105                 110         


Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser Ala Ser 
        115                 120                 125             


Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr Tyr Asp 
    130                 135                 140                 


Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His Asp Leu 
145                 150                 155                 160 


Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu Ser Asn 
                165                 170                 175     


Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu Lys Glu 
            180                 185                 190         


Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu Ala Ile 
        195                 200                 205             


Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln Glu Ile 
    210                 215                 220                 


Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln Val Tyr 
225                 230                 235                 240 


Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile Ala Lys 
                245                 250                 255     


Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp Leu Lys 
            260                 265                 270         


Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys Gln Glu 
        275                 280                 285             


Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp Leu Trp 
    290                 295                 300                 


Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln Phe Lys 
                325                 330                 335     


Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu Asn Asp 
            340                 345                 350         


Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr Ile Cys 
        355                 360                 365             


Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys Ala Trp 
    370                 375                 380                 


Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu Cys Asp 
385                 390                 395                 400 


Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile Leu Arg 
                405                 410                 415     


Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile Leu Ala 
            420                 425                 430         


Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln Lys Ala 
        435                 440                 445             


Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn Ala Val 
    450                 455                 460                 


Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser Leu Asp 
465                 470                 475                 480 


Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly Arg Trp 
                485                 490                 495     


Lys Lys Ala His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln Glu Ile 
            500                 505                 510         


Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg Thr Pro 
        515                 520                 525             


Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala Ile Arg 
    530                 535                 540                 


Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg Ile Arg 
545                 550                 555                 560 


Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys Ile Thr 
                565                 570                 575     


Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile Pro Val 
            580                 585                 590         


Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly Asp Arg 
        595                 600                 605             


Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr Ser Leu 
    610                 615                 620                 


Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly Cys Phe 
625                 630                 635                 640 


Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu Asn Arg 
                645                 650                 655     


Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr Pro Gln 
            660                 665                 670         


Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu Trp Gln 
        675                 680                 685             


Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu Ala Lys 
    690                 695                 700                 


Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr Lys Phe 
705                 710                 715                 720 


Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly Lys Ser 
                725                 730                 735     


Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe Ile Glu 
            740                 745                 750         


Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser Thr Leu 
        755                 760                 765             


Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe Ser Thr 
    770                 775                 780                 


Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln Arg Lys 
785                 790                 795                 800 


Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu Leu Ile 
                805                 810                 815     


Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn Ser Leu 
            820                 825                 830         


Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly Glu Gly 
        835                 840                 845             


Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn Ser Arg 
    850                 855                 860                 


Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg Gln Leu 
865                 870                 875                 880 


Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu Tyr Thr 
                885                 890                 895     


Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala Met Lys 
            900                 905                 910         


Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp Val Leu 
        915                 920                 925             


Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr Gly Glu 
    930                 935                 940                 


Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu Leu Gln 
945                 950                 955                 960 


Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys Ser Asn 
                965                 970                 975     


Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu Gly Asn 
            980                 985                 990         


Lys Glu Ala Val Val Tyr Ile Pro  Val Arg Gly Gly Arg  Ile Tyr Phe 
        995                 1000                 1005             


Ala Thr  His Lys Val Ala Thr  Gly Ala Val Ser Ile  Val Phe Asp 
    1010                 1015                 1020             


Gln Lys  Gln Val Trp Val Cys  Asn Ala Asp His Val  Ala Ala Ala 
    1025                 1030                 1035             


Asn Ile  Ala Leu Thr Gly Lys  Gly Ile Gly Glu Gln  Ser Ser Asp 
    1040                 1045                 1050             


Glu Glu  Asn Pro Asp Gly Ser  Arg Ile Lys Leu Gln  Leu Thr Ser 
    1055                 1060                 1065             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1070                 1075                 1080             


Lys Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1085                 1090                 1095             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1100                 1105                 1110             


Gly Gly  Ser Thr Leu Asn Ile  Glu Asp Glu Tyr Arg  Leu His Glu 
    1115                 1120                 1125             


Thr Ser  Lys Glu Pro Asp Val  Ser Leu Gly Ser Thr  Trp Leu Ser 
    1130                 1135                 1140             


Asp Phe  Pro Gln Ala Trp Ala  Glu Thr Gly Gly Met  Gly Leu Ala 
    1145                 1150                 1155             


Val Arg  Gln Ala Pro Leu Ile  Ile Pro Leu Lys Ala  Thr Ser Thr 
    1160                 1165                 1170             


Pro Val  Ser Ile Lys Gln Tyr  Pro Met Ser Gln Glu  Ala Arg Leu 
    1175                 1180                 1185             


Gly Ile  Lys Pro His Ile Gln  Arg Leu Leu Asp Gln  Gly Ile Leu 
    1190                 1195                 1200             


Val Pro  Cys Gln Ser Pro Trp  Asn Thr Pro Leu Leu  Pro Val Lys 
    1205                 1210                 1215             


Lys Pro  Gly Thr Asn Asp Tyr  Arg Pro Val Gln Asp  Leu Arg Glu 
    1220                 1225                 1230             


Val Asn  Lys Arg Val Glu Asp  Ile His Pro Thr Val  Pro Asn Pro 
    1235                 1240                 1245             


Tyr Asn  Leu Leu Ser Gly Leu  Pro Pro Ser His Gln  Trp Tyr Thr 
    1250                 1255                 1260             


Val Leu  Asp Leu Lys Asp Ala  Phe Phe Cys Leu Arg  Leu His Pro 
    1265                 1270                 1275             


Thr Ser  Gln Pro Leu Phe Ala  Phe Glu Trp Arg Asp  Pro Glu Met 
    1280                 1285                 1290             


Gly Ile  Ser Gly Gln Leu Thr  Trp Thr Arg Leu Pro  Gln Gly Phe 
    1295                 1300                 1305             


Lys Asn  Ser Pro Thr Leu Phe  Asn Glu Ala Leu His  Arg Asp Leu 
    1310                 1315                 1320             


Ala Asp  Phe Arg Ile Gln His  Pro Asp Leu Ile Leu  Leu Gln Tyr 
    1325                 1330                 1335             


Val Asp  Asp Leu Leu Leu Ala  Ala Thr Ser Glu Leu  Asp Cys Gln 
    1340                 1345                 1350             


Gln Gly  Thr Arg Ala Leu Leu  Gln Thr Leu Gly Asn  Leu Gly Tyr 
    1355                 1360                 1365             


Arg Ala  Ser Ala Lys Lys Ala  Gln Ile Cys Gln Lys  Gln Val Lys 
    1370                 1375                 1380             


Tyr Leu  Gly Tyr Leu Leu Lys  Glu Gly Gln Arg Trp  Leu Thr Glu 
    1385                 1390                 1395             


Ala Arg  Lys Glu Thr Val Met  Gly Gln Pro Thr Pro  Lys Thr Pro 
    1400                 1405                 1410             


Arg Gln  Leu Arg Glu Phe Leu  Gly Lys Ala Gly Phe  Cys Arg Leu 
    1415                 1420                 1425             


Phe Ile  Pro Gly Phe Ala Glu  Met Ala Ala Pro Leu  Tyr Pro Leu 
    1430                 1435                 1440             


Thr Lys  Pro Gly Thr Leu Phe  Asn Trp Gly Pro Asp  Gln Gln Lys 
    1445                 1450                 1455             


Ala Tyr  Gln Glu Ile Lys Gln  Ala Leu Leu Thr Ala  Pro Ala Leu 
    1460                 1465                 1470             


Gly Leu  Pro Asp Leu Thr Lys  Pro Phe Glu Leu Phe  Val Asp Glu 
    1475                 1480                 1485             


Lys Gln  Gly Tyr Ala Lys Gly  Val Leu Thr Gln Lys  Leu Gly Pro 
    1490                 1495                 1500             


Trp Arg  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Pro Val 
    1505                 1510                 1515             


Ala Ala  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1520                 1525                 1530             


Val Leu  Thr Lys Asp Ala Gly  Lys Leu Thr Met Gly  Gln Pro Leu 
    1535                 1540                 1545             


Val Ile  Leu Ala Pro His Ala  Val Glu Ala Leu Val  Lys Gln Pro 
    1550                 1555                 1560             


Pro Asp  Arg Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1565                 1570                 1575             


Leu Leu  Leu Asp Thr Asp Arg  Val Gln Phe Gly Pro  Val Val Ala 
    1580                 1585                 1590             


Leu Asn  Pro Ala Thr Leu Leu  Pro Leu Pro Glu Glu  Gly Leu Gln 
    1595                 1600                 1605             


His Asn  Cys Leu Asp Ile Leu  Ala Glu Ala His Gly  Thr Arg Pro 
    1610                 1615                 1620             


Asp Leu  Thr Asp Gln Pro Leu  Pro Asp Ala Asp His  Thr Trp Tyr 
    1625                 1630                 1635             


Thr Asp  Gly Ser Ser Leu Leu  Gln Glu Gly Gln Arg  Lys Ala Gly 
    1640                 1645                 1650             


Ala Ala  Val Thr Thr Glu Thr  Glu Val Ile Trp Ala  Lys Ala Leu 
    1655                 1660                 1665             


Pro Ala  Gly Thr Ser Ala Gln  Arg Ala Glu Leu Ile  Ala Leu Thr 
    1670                 1675                 1680             


Gln Ala  Leu Lys Met Ala Glu  Gly Lys Lys Leu Asn  Val Tyr Thr 
    1685                 1690                 1695             


Asp Ser  Arg Tyr Ala Phe Ala  Thr Ala His Ile His  Gly Glu Ile 
    1700                 1705                 1710             


Tyr Arg  Arg Arg Gly Trp Leu  Thr Ser Glu Gly Lys  Glu Ile Lys 
    1715                 1720                 1725             


Asn Lys  Asp Glu Ile Leu Ala  Leu Leu Lys Ala Leu  Phe Leu Pro 
    1730                 1735                 1740             


Lys Arg  Leu Ser Ile Ile His  Cys Pro Gly His Gln  Lys Gly His 
    1745                 1750                 1755             


Ser Ala  Glu Ala Arg Gly Asn  Arg Met Ala Asp Gln  Ala Ala Arg 
    1760                 1765                 1770             


Lys Ala  Ala Ile Thr Glu Thr  Pro Asp Thr Ser Thr  Leu Leu Ile 
    1775                 1780                 1785             


Glu Asn  Ser Ser Pro Met Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1790                 1795                 1800             


Glu Ser  Pro Lys Lys Lys Arg  Lys Val 
    1805                 1810         


<210>  220
<211>  1620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  220

Met Lys Ile Glu Glu Gly Lys Gly His His His His His His Met Ser 
1               5                   10                  15      


Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu Arg Lys 
            20                  25                  30          


Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly Ser Ala 
        35                  40                  45              


Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr Pro Glu 
    50                  55                  60                  


Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp Ile Ala 
65                  70                  75                  80  


Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp Ser Leu 
                85                  90                  95      


Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu Glu Tyr 
            100                 105                 110         


Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser Ala Ser 
        115                 120                 125             


Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr Tyr Asp 
    130                 135                 140                 


Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His Asp Leu 
145                 150                 155                 160 


Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu Ser Asn 
                165                 170                 175     


Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu Lys Glu 
            180                 185                 190         


Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu Ala Ile 
        195                 200                 205             


Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln Glu Ile 
    210                 215                 220                 


Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln Val Tyr 
225                 230                 235                 240 


Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile Ala Lys 
                245                 250                 255     


Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp Leu Lys 
            260                 265                 270         


Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys Gln Glu 
        275                 280                 285             


Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp Leu Trp 
    290                 295                 300                 


Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln Phe Lys 
                325                 330                 335     


Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu Asn Asp 
            340                 345                 350         


Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr Ile Cys 
        355                 360                 365             


Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys Ala Trp 
    370                 375                 380                 


Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu Cys Asp 
385                 390                 395                 400 


Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile Leu Arg 
                405                 410                 415     


Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile Leu Ala 
            420                 425                 430         


Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln Lys Ala 
        435                 440                 445             


Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn Ala Val 
    450                 455                 460                 


Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser Leu Asp 
465                 470                 475                 480 


Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly Arg Trp 
                485                 490                 495     


Lys Lys Ala His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln Glu Ile 
            500                 505                 510         


Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg Thr Pro 
        515                 520                 525             


Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala Ile Arg 
    530                 535                 540                 


Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg Ile Arg 
545                 550                 555                 560 


Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys Ile Thr 
                565                 570                 575     


Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile Pro Val 
            580                 585                 590         


Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly Asp Arg 
        595                 600                 605             


Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr Ser Leu 
    610                 615                 620                 


Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg Cys Arg 
625                 630                 635                 640 


Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu Asn Arg 
                645                 650                 655     


Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr Pro Gln 
            660                 665                 670         


Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu Trp Gln 
        675                 680                 685             


Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu Ala Lys 
    690                 695                 700                 


Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr Lys Phe 
705                 710                 715                 720 


Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly Lys Ser 
                725                 730                 735     


Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe Ile Glu 
            740                 745                 750         


Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser Thr Leu 
        755                 760                 765             


Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe Ser Thr 
    770                 775                 780                 


Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln Arg Lys 
785                 790                 795                 800 


Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu Leu Ile 
                805                 810                 815     


Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn Ser Leu 
            820                 825                 830         


Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly Glu Gly 
        835                 840                 845             


Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn Ser Arg 
    850                 855                 860                 


Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg Gln Leu 
865                 870                 875                 880 


Ala Thr Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu Tyr Thr 
                885                 890                 895     


Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala Met Lys 
            900                 905                 910         


Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp Val Leu 
        915                 920                 925             


Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr Gly Glu 
    930                 935                 940                 


Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu Leu Gln 
945                 950                 955                 960 


Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys Ser Asn 
                965                 970                 975     


Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu Gly Asn 
            980                 985                 990         


Lys Glu Ala Val Val Tyr Ile Pro  Val Arg Gly Gly Arg  Ile Tyr Phe 
        995                 1000                 1005             


Ala Thr  His Lys Val Ala Thr  Gly Ala Val Ser Ile  Val Phe Asp 
    1010                 1015                 1020             


Gln Lys  Gln Val Trp Val Cys  Asn Ala Asp His Val  Ala Ala Ala 
    1025                 1030                 1035             


Asn Ile  Ala Leu Thr Gly Lys  Gly Ile Gly Arg Gln  Ser Ser Asp 
    1040                 1045                 1050             


Glu Glu  Asn Pro Asp Gly Gly  Arg Ile Lys Leu Gln  Leu Thr Ser 
    1055                 1060                 1065             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1070                 1075                 1080             


Lys Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1085                 1090                 1095             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1100                 1105                 1110             


Gly Gly  Ser Thr Leu Asn Ile  Glu Asp Glu Tyr Arg  Leu His Glu 
    1115                 1120                 1125             


Thr Ser  Lys Glu Pro Asp Val  Ser Leu Gly Ser Thr  Trp Leu Ser 
    1130                 1135                 1140             


Asp Phe  Pro Gln Ala Trp Ala  Glu Thr Gly Gly Met  Gly Leu Ala 
    1145                 1150                 1155             


Val Arg  Gln Ala Pro Leu Ile  Ile Pro Leu Lys Ala  Thr Ser Thr 
    1160                 1165                 1170             


Pro Val  Ser Ile Lys Gln Tyr  Pro Met Ser Gln Glu  Ala Arg Leu 
    1175                 1180                 1185             


Gly Ile  Lys Pro His Ile Gln  Arg Leu Leu Asp Gln  Gly Ile Leu 
    1190                 1195                 1200             


Val Pro  Cys Gln Ser Pro Trp  Asn Thr Pro Leu Leu  Pro Val Lys 
    1205                 1210                 1215             


Lys Pro  Gly Thr Asn Asp Tyr  Arg Pro Val Gln Asp  Leu Arg Glu 
    1220                 1225                 1230             


Val Asn  Lys Arg Val Glu Asp  Ile His Pro Thr Val  Pro Asn Pro 
    1235                 1240                 1245             


Tyr Asn  Leu Leu Ser Gly Leu  Pro Pro Ser His Gln  Trp Tyr Thr 
    1250                 1255                 1260             


Val Leu  Asp Leu Lys Asp Ala  Phe Phe Cys Leu Arg  Leu His Pro 
    1265                 1270                 1275             


Thr Ser  Gln Pro Leu Phe Ala  Phe Glu Trp Arg Asp  Pro Glu Met 
    1280                 1285                 1290             


Gly Ile  Ser Gly Gln Leu Thr  Trp Thr Arg Leu Pro  Gln Gly Phe 
    1295                 1300                 1305             


Lys Asn  Ser Pro Thr Leu Phe  Asn Glu Ala Leu His  Arg Asp Leu 
    1310                 1315                 1320             


Ala Asp  Phe Arg Ile Gln His  Pro Asp Leu Ile Leu  Leu Gln Tyr 
    1325                 1330                 1335             


Val Asp  Asp Leu Leu Leu Ala  Ala Thr Ser Glu Leu  Asp Cys Gln 
    1340                 1345                 1350             


Gln Gly  Thr Arg Ala Leu Leu  Gln Thr Leu Gly Asn  Leu Gly Tyr 
    1355                 1360                 1365             


Arg Ala  Ser Ala Lys Lys Ala  Gln Ile Cys Gln Lys  Gln Val Lys 
    1370                 1375                 1380             


Tyr Leu  Gly Tyr Leu Leu Lys  Glu Gly Gln Arg Trp  Leu Thr Glu 
    1385                 1390                 1395             


Ala Arg  Lys Glu Thr Val Met  Gly Gln Pro Thr Pro  Lys Thr Pro 
    1400                 1405                 1410             


Arg Gln  Leu Arg Glu Phe Leu  Gly Lys Ala Gly Phe  Cys Arg Leu 
    1415                 1420                 1425             


Phe Ile  Pro Gly Phe Ala Glu  Met Ala Ala Pro Leu  Tyr Pro Leu 
    1430                 1435                 1440             


Thr Lys  Pro Gly Thr Leu Phe  Asn Trp Gly Pro Asp  Gln Gln Lys 
    1445                 1450                 1455             


Ala Tyr  Gln Glu Ile Lys Gln  Ala Leu Leu Thr Ala  Pro Ala Leu 
    1460                 1465                 1470             


Gly Leu  Pro Asp Leu Thr Lys  Pro Phe Glu Leu Phe  Val Asp Glu 
    1475                 1480                 1485             


Lys Gln  Gly Tyr Ala Lys Gly  Val Leu Thr Gln Lys  Leu Gly Pro 
    1490                 1495                 1500             


Trp Arg  Arg Pro Val Ala Tyr  Leu Ser Lys Lys Leu  Asp Pro Val 
    1505                 1510                 1515             


Ala Ala  Gly Trp Pro Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala 
    1520                 1525                 1530             


Val Leu  Thr Lys Asp Ala Gly  Lys Leu Thr Met Gly  Gln Pro Leu 
    1535                 1540                 1545             


Val Ile  Leu Ala Pro His Ala  Val Glu Ala Leu Val  Lys Gln Pro 
    1550                 1555                 1560             


Pro Asp  Arg Trp Leu Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala 
    1565                 1570                 1575             


Leu Leu  Leu Asp Thr Asp Arg  Val Gln Phe Gly Pro  Val Val Ala 
    1580                 1585                 1590             


Leu Asn  Pro Ala Thr Leu Leu  Pro Met Lys Arg Thr  Ala Asp Gly 
    1595                 1600                 1605             


Ser Glu  Phe Glu Ser Pro Lys  Lys Lys Arg Lys Val  
    1610                 1615                 1620 


<210>  221
<211>  1562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  221

Met Lys Ile Glu Glu Gly Lys Gly His His His His His His Met Ser 
1               5                   10                  15      


Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu Arg Lys 
            20                  25                  30          


Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly Ser Ala 
        35                  40                  45              


Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr Pro Glu 
    50                  55                  60                  


Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp Ile Ala 
65                  70                  75                  80  


Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp Ser Leu 
                85                  90                  95      


Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu Glu Tyr 
            100                 105                 110         


Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser Ala Ser 
        115                 120                 125             


Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr Tyr Asp 
    130                 135                 140                 


Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His Asp Leu 
145                 150                 155                 160 


Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu Ser Asn 
                165                 170                 175     


Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu Lys Glu 
            180                 185                 190         


Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu Ala Ile 
        195                 200                 205             


Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln Glu Ile 
    210                 215                 220                 


Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln Val Tyr 
225                 230                 235                 240 


Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile Ala Lys 
                245                 250                 255     


Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp Leu Lys 
            260                 265                 270         


Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys Gln Glu 
        275                 280                 285             


Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp Leu Trp 
    290                 295                 300                 


Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln Phe Lys 
                325                 330                 335     


Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu Asn Asp 
            340                 345                 350         


Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr Ile Cys 
        355                 360                 365             


Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys Ala Trp 
    370                 375                 380                 


Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu Cys Asp 
385                 390                 395                 400 


Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile Leu Arg 
                405                 410                 415     


Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile Leu Ala 
            420                 425                 430         


Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln Lys Ala 
        435                 440                 445             


Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn Ala Val 
    450                 455                 460                 


Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser Leu Asp 
465                 470                 475                 480 


Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly Arg Trp 
                485                 490                 495     


Lys Lys Ala His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln Glu Ile 
            500                 505                 510         


Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg Thr Pro 
        515                 520                 525             


Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala Ile Arg 
    530                 535                 540                 


Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg Ile Arg 
545                 550                 555                 560 


Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys Ile Thr 
                565                 570                 575     


Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile Pro Val 
            580                 585                 590         


Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly Asp Arg 
        595                 600                 605             


Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr Ser Leu 
    610                 615                 620                 


Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg Cys Arg 
625                 630                 635                 640 


Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu Asn Arg 
                645                 650                 655     


Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr Pro Gln 
            660                 665                 670         


Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu Trp Gln 
        675                 680                 685             


Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu Ala Lys 
    690                 695                 700                 


Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr Lys Phe 
705                 710                 715                 720 


Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly Lys Ser 
                725                 730                 735     


Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe Ile Glu 
            740                 745                 750         


Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser Thr Leu 
        755                 760                 765             


Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe Ser Thr 
    770                 775                 780                 


Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln Arg Lys 
785                 790                 795                 800 


Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu Leu Ile 
                805                 810                 815     


Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn Ser Leu 
            820                 825                 830         


Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly Glu Gly 
        835                 840                 845             


Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn Ser Arg 
    850                 855                 860                 


Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg Gln Leu 
865                 870                 875                 880 


Ala Thr Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu Tyr Thr 
                885                 890                 895     


Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala Met Lys 
            900                 905                 910         


Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp Val Leu 
        915                 920                 925             


Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr Gly Glu 
    930                 935                 940                 


Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu Leu Gln 
945                 950                 955                 960 


Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys Ser Asn 
                965                 970                 975     


Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu Gly Asn 
            980                 985                 990         


Lys Glu Ala Val Val Tyr Ile Pro  Val Arg Gly Gly Arg  Ile Tyr Phe 
        995                 1000                 1005             


Ala Thr  His Lys Val Ala Thr  Gly Ala Val Ser Ile  Val Phe Asp 
    1010                 1015                 1020             


Gln Lys  Gln Val Trp Val Cys  Asn Ala Asp His Val  Ala Ala Ala 
    1025                 1030                 1035             


Asn Ile  Ala Leu Thr Gly Lys  Gly Ile Gly Arg Gln  Ser Ser Asp 
    1040                 1045                 1050             


Glu Glu  Asn Pro Asp Gly Gly  Arg Ile Lys Leu Gln  Leu Thr Ser 
    1055                 1060                 1065             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1070                 1075                 1080             


Lys Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1085                 1090                 1095             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1100                 1105                 1110             


Gly Gly  Ser Met Asp Thr Ser  Asn Leu Met Glu Gln  Ile Leu Ser 
    1115                 1120                 1125             


Ser Asp  Asn Leu Asn Arg Ala  Tyr Leu Gln Val Val  Arg Asn Lys 
    1130                 1135                 1140             


Gly Ala  Glu Gly Val Asp Gly  Met Lys Tyr Thr Glu  Leu Lys Glu 
    1145                 1150                 1155             


His Leu  Ala Lys Asn Gly Glu  Thr Ile Lys Gly Gln  Leu Arg Thr 
    1160                 1165                 1170             


Arg Lys  Tyr Lys Pro Gln Pro  Ala Arg Arg Val Glu  Ile Pro Lys 
    1175                 1180                 1185             


Pro Asp  Gly Gly Val Arg Asn  Leu Gly Val Pro Thr  Val Thr Asp 
    1190                 1195                 1200             


Arg Phe  Ile Gln Gln Ala Ile  Ala Gln Val Leu Thr  Pro Ile Tyr 
    1205                 1210                 1215             


Glu Glu  Gln Phe His Asp His  Ser Tyr Gly Phe Arg  Pro Asn Arg 
    1220                 1225                 1230             


Cys Ala  Gln Gln Ala Ile Leu  Thr Ala Leu Asn Ile  Met Asn Asp 
    1235                 1240                 1245             


Gly Asn  Asp Trp Ile Val Asp  Ile Asp Leu Glu Lys  Phe Phe Asp 
    1250                 1255                 1260             


Thr Val  Asn His Asp Lys Leu  Met Thr Leu Ile Gly  Arg Thr Ile 
    1265                 1270                 1275             


Lys Asp  Gly Asp Val Ile Ser  Ile Val Arg Lys Tyr  Leu Val Ser 
    1280                 1285                 1290             


Gly Ile  Met Ile Asp Asp Glu  Tyr Glu Asp Ser Ile  Val Gly Thr 
    1295                 1300                 1305             


Pro Gln  Gly Gly Asn Leu Ser  Pro Leu Leu Ala Asn  Ile Met Leu 
    1310                 1315                 1320             


Asn Glu  Leu Asp Lys Glu Met  Glu Lys Arg Gly Leu  Asn Phe Val 
    1325                 1330                 1335             


Arg Tyr  Ala Asp Asp Cys Ile  Ile Met Val Gly Ser  Glu Met Ser 
    1340                 1345                 1350             


Ala Asn  Arg Val Met Arg Asn  Ile Ser Arg Phe Ile  Glu Glu Lys 
    1355                 1360                 1365             


Leu Gly  Leu Lys Val Asn Met  Thr Lys Ser Lys Val  Asp Arg Pro 
    1370                 1375                 1380             


Ser Gly  Leu Lys Tyr Leu Gly  Phe Gly Phe Tyr Phe  Asp Pro Arg 
    1385                 1390                 1395             


Ala His  Gln Phe Lys Ala Lys  Pro His Ala Lys Ser  Val Ala Lys 
    1400                 1405                 1410             


Phe Lys  Lys Arg Met Lys Glu  Leu Thr Cys Arg Ser  Trp Gly Val 
    1415                 1420                 1425             


Ser Asn  Ser Tyr Lys Val Glu  Lys Leu Asn Gln Leu  Ile Arg Gly 
    1430                 1435                 1440             


Trp Ile  Asn Tyr Phe Lys Ile  Gly Ser Met Lys Thr  Leu Cys Lys 
    1445                 1450                 1455             


Glu Leu  Asp Ser Arg Ile Arg  Tyr Arg Leu Arg Met  Cys Ile Trp 
    1460                 1465                 1470             


Lys Gln  Trp Lys Thr Pro Gln  Asn Gln Glu Lys Asn  Leu Val Lys 
    1475                 1480                 1485             


Leu Gly  Ile Asp Arg Asn Thr  Ala Arg Arg Val Ala  Tyr Thr Gly 
    1490                 1495                 1500             


Lys Arg  Ile Ala Tyr Val Cys  Asn Lys Gly Ala Val  Asn Val Ala 
    1505                 1510                 1515             


Ile Ser  Asn Lys Arg Leu Ala  Ser Phe Gly Leu Ile  Ser Met Leu 
    1520                 1525                 1530             


Asp Tyr  Tyr Ile Glu Lys Cys  Val Thr Cys Met Lys  Arg Thr Ala 
    1535                 1540                 1545             


Asp Gly  Ser Glu Phe Glu Ser  Pro Lys Lys Lys Arg  Lys Val 
    1550                 1555                 1560         


<210>  222
<211>  1548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  222

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Asp Thr Ser Asn Leu Met Glu Gln Ile Leu Ser Ser 
            20                  25                  30          


Asp Asn Leu Asn Arg Ala Tyr Leu Gln Val Val Arg Asn Lys Gly Ala 
        35                  40                  45              


Glu Gly Val Asp Gly Met Lys Tyr Thr Glu Leu Lys Glu His Leu Ala 
    50                  55                  60                  


Lys Asn Gly Glu Thr Ile Lys Gly Gln Leu Arg Thr Arg Lys Tyr Lys 
65                  70                  75                  80  


Pro Gln Pro Ala Arg Arg Val Glu Ile Pro Lys Pro Asp Gly Gly Val 
                85                  90                  95      


Arg Asn Leu Gly Val Pro Thr Val Thr Asp Arg Phe Ile Gln Gln Ala 
            100                 105                 110         


Ile Ala Gln Val Leu Thr Pro Ile Tyr Glu Glu Gln Phe His Asp His 
        115                 120                 125             


Ser Tyr Gly Phe Arg Pro Asn Arg Cys Ala Gln Gln Ala Ile Leu Thr 
    130                 135                 140                 


Ala Leu Asn Ile Met Asn Asp Gly Asn Asp Trp Ile Val Asp Ile Asp 
145                 150                 155                 160 


Leu Glu Lys Phe Phe Asp Thr Val Asn His Asp Lys Leu Met Thr Leu 
                165                 170                 175     


Ile Gly Arg Thr Ile Lys Asp Gly Asp Val Ile Ser Ile Val Arg Lys 
            180                 185                 190         


Tyr Leu Val Ser Gly Ile Met Ile Asp Asp Glu Tyr Glu Asp Ser Ile 
        195                 200                 205             


Val Gly Thr Pro Gln Gly Gly Asn Leu Ser Pro Leu Leu Ala Asn Ile 
    210                 215                 220                 


Met Leu Asn Glu Leu Asp Lys Glu Met Glu Lys Arg Gly Leu Asn Phe 
225                 230                 235                 240 


Val Arg Tyr Ala Asp Asp Cys Ile Ile Met Val Gly Ser Glu Met Ser 
                245                 250                 255     


Ala Asn Arg Val Met Arg Asn Ile Ser Arg Phe Ile Glu Glu Lys Leu 
            260                 265                 270         


Gly Leu Lys Val Asn Met Thr Lys Ser Lys Val Asp Arg Pro Ser Gly 
        275                 280                 285             


Leu Lys Tyr Leu Gly Phe Gly Phe Tyr Phe Asp Pro Arg Ala His Gln 
    290                 295                 300                 


Phe Lys Ala Lys Pro His Ala Lys Ser Val Ala Lys Phe Lys Lys Arg 
305                 310                 315                 320 


Met Lys Glu Leu Thr Cys Arg Ser Trp Gly Val Ser Asn Ser Tyr Lys 
                325                 330                 335     


Val Glu Lys Leu Asn Gln Leu Ile Arg Gly Trp Ile Asn Tyr Phe Lys 
            340                 345                 350         


Ile Gly Ser Met Lys Thr Leu Cys Lys Glu Leu Asp Ser Arg Ile Arg 
        355                 360                 365             


Tyr Arg Leu Arg Met Cys Ile Trp Lys Gln Trp Lys Thr Pro Gln Asn 
    370                 375                 380                 


Gln Glu Lys Asn Leu Val Lys Leu Gly Ile Asp Arg Asn Thr Ala Arg 
385                 390                 395                 400 


Arg Val Ala Tyr Thr Gly Lys Arg Ile Ala Tyr Val Cys Asn Lys Gly 
                405                 410                 415     


Ala Val Asn Val Ala Ile Ser Asn Lys Arg Leu Ala Ser Phe Gly Leu 
            420                 425                 430         


Ile Ser Met Leu Asp Tyr Tyr Ile Glu Lys Cys Val Thr Cys Ser Gly 
        435                 440                 445             


Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
    450                 455                 460                 


Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ser 
465                 470                 475                 480 


Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu Arg Lys 
                485                 490                 495     


Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly Ser Ala 
            500                 505                 510         


Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr Pro Glu 
        515                 520                 525             


Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp Ile Ala 
    530                 535                 540                 


Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp Ser Leu 
545                 550                 555                 560 


Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu Glu Tyr 
                565                 570                 575     


Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser Ala Ser 
            580                 585                 590         


Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr Tyr Asp 
        595                 600                 605             


Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His Asp Leu 
    610                 615                 620                 


Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu Ser Asn 
625                 630                 635                 640 


Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu Lys Glu 
                645                 650                 655     


Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu Ala Ile 
            660                 665                 670         


Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln Glu Ile 
        675                 680                 685             


Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln Val Tyr 
    690                 695                 700                 


Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile Ala Lys 
705                 710                 715                 720 


Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp Leu Lys 
                725                 730                 735     


Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys Gln Glu 
            740                 745                 750         


Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp Leu Trp 
        755                 760                 765             


Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys Ile Lys 
    770                 775                 780                 


Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln Phe Lys 
785                 790                 795                 800 


Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu Asn Asp 
                805                 810                 815     


Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr Ile Cys 
            820                 825                 830         


Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys Ala Trp 
        835                 840                 845             


Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu Cys Asp 
    850                 855                 860                 


Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile Leu Arg 
865                 870                 875                 880 


Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile Leu Ala 
                885                 890                 895     


Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln Lys Ala 
            900                 905                 910         


Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn Ala Val 
        915                 920                 925             


Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser Leu Asp 
    930                 935                 940                 


Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly Arg Trp 
945                 950                 955                 960 


Lys Lys Ala His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln Glu Ile 
                965                 970                 975     


Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg Thr Pro 
            980                 985                 990         


Arg Phe Gly Tyr His Leu Pro Lys  Leu Thr Asp Gln Thr  Ala Ile Arg 
        995                 1000                 1005             


Val Asn  Lys Lys His Val Lys  Ala Ala Lys Thr Glu  Ala Arg Ile 
    1010                 1015                 1020             


Arg Leu  Ala Ile Gln Gln Gly  Thr Leu Pro Val Ser  Asn Leu Lys 
    1025                 1030                 1035             


Ile Thr  Glu Ile Ser Ala Thr  Ile Asn Ser Lys Gly  Gln Val Arg 
    1040                 1045                 1050             


Ile Pro  Val Lys Phe Arg Val  Gly Arg Gln Lys Gly  Thr Leu Gln 
    1055                 1060                 1065             


Ile Gly  Asp Arg Phe Cys Gly  Tyr Asp Gln Asn Gln  Thr Ala Ser 
    1070                 1075                 1080             


His Ala  Tyr Ser Leu Trp Glu  Val Val Lys Glu Gly  Gln Tyr His 
    1085                 1090                 1095             


Lys Glu  Leu Gly Cys Phe Val  Arg Phe Ile Ser Ser  Gly Asp Ile 
    1100                 1105                 1110             


Val Ser  Ile Thr Glu Asn Arg  Gly Asn Gln Phe Asp  Gln Leu Ser 
    1115                 1120                 1125             


Tyr Glu  Gly Leu Ala Tyr Pro  Gln Tyr Ala Asp Trp  Arg Lys Lys 
    1130                 1135                 1140             


Ala Ser  Lys Phe Val Ser Leu  Trp Gln Ile Thr Lys  Lys Asn Lys 
    1145                 1150                 1155             


Lys Lys  Glu Ile Val Thr Val  Glu Ala Lys Glu Lys  Phe Asp Ala 
    1160                 1165                 1170             


Ile Cys  Lys Tyr Gln Pro Arg  Leu Tyr Lys Phe Asn  Lys Glu Tyr 
    1175                 1180                 1185             


Ala Tyr  Leu Leu Arg Asp Ile  Val Arg Gly Lys Ser  Leu Val Glu 
    1190                 1195                 1200             


Leu Gln  Gln Ile Arg Gln Glu  Ile Phe Arg Phe Ile  Glu Gln Asp 
    1205                 1210                 1215             


Cys Gly  Val Thr Arg Leu Gly  Ser Leu Ser Leu Ser  Thr Leu Glu 
    1220                 1225                 1230             


Thr Val  Lys Ala Val Lys Gly  Ile Ile Tyr Ser Tyr  Phe Ser Thr 
    1235                 1240                 1245             


Ala Leu  Asn Ala Ser Lys Asn  Asn Pro Ile Ser Asp  Glu Gln Arg 
    1250                 1255                 1260             


Lys Glu  Phe Asp Pro Glu Leu  Phe Ala Leu Leu Glu  Lys Leu Glu 
    1265                 1270                 1275             


Leu Ile  Arg Thr Arg Lys Lys  Lys Gln Lys Val Glu  Arg Ile Ala 
    1280                 1285                 1290             


Asn Ser  Leu Ile Gln Thr Cys  Leu Glu Asn Asn Ile  Lys Phe Ile 
    1295                 1300                 1305             


Arg Gly  Glu Gly Asp Leu Ser  Thr Thr Asn Asn Ala  Thr Lys Lys 
    1310                 1315                 1320             


Lys Ala  Asn Ser Arg Ser Met  Asp Trp Leu Ala Arg  Gly Val Phe 
    1325                 1330                 1335             


Asn Lys  Ile Arg Gln Leu Ala  Pro Met His Asn Ile  Thr Leu Phe 
    1340                 1345                 1350             


Gly Cys  Gly Ser Leu Tyr Thr  Ser His Gln Asp Pro  Leu Val His 
    1355                 1360                 1365             


Arg Asn  Pro Asp Lys Ala Met  Lys Cys Arg Trp Ala  Ala Ile Pro 
    1370                 1375                 1380             


Val Lys  Asp Ile Gly Asp Trp  Val Leu Arg Lys Leu  Ser Gln Asn 
    1385                 1390                 1395             


Leu Arg  Ala Lys Asn Arg Gly  Thr Gly Glu Tyr Tyr  His Gln Gly 
    1400                 1405                 1410             


Val Lys  Glu Phe Leu Ser His  Tyr Glu Leu Gln Asp  Leu Glu Glu 
    1415                 1420                 1425             


Glu Leu  Leu Lys Trp Arg Ser  Asp Arg Lys Ser Asn  Ile Pro Cys 
    1430                 1435                 1440             


Trp Val  Leu Gln Asn Arg Leu  Ala Glu Lys Leu Gly  Asn Lys Glu 
    1445                 1450                 1455             


Ala Val  Val Tyr Ile Pro Val  Arg Gly Gly Arg Ile  Tyr Phe Ala 
    1460                 1465                 1470             


Thr His  Lys Val Ala Thr Gly  Ala Val Ser Ile Val  Phe Asp Gln 
    1475                 1480                 1485             


Lys Gln  Val Trp Val Cys Asn  Ala Asp His Val Ala  Ala Ala Asn 
    1490                 1495                 1500             


Ile Ala  Leu Thr Gly Lys Gly  Ile Gly Glu Gln Ser  Ser Asp Glu 
    1505                 1510                 1515             


Glu Asn  Pro Asp Gly Ser Arg  Ile Lys Leu Gln Leu  Thr Ser Lys 
    1520                 1525                 1530             


Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1535                 1540                 1545             


<210>  223
<211>  1548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  223

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Asp Thr Ser Asn Leu Met Glu Gln Ile Leu Ser Ser 
            20                  25                  30          


Asp Asn Leu Asn Arg Ala Tyr Leu Gln Val Val Arg Asn Lys Gly Ala 
        35                  40                  45              


Glu Gly Val Asp Gly Met Lys Tyr Thr Glu Leu Lys Glu His Leu Ala 
    50                  55                  60                  


Lys Asn Gly Glu Thr Ile Lys Gly Gln Leu Arg Thr Arg Lys Tyr Lys 
65                  70                  75                  80  


Pro Gln Pro Ala Arg Arg Val Glu Ile Pro Lys Pro Asp Gly Gly Val 
                85                  90                  95      


Arg Asn Leu Gly Val Pro Thr Val Thr Asp Arg Phe Ile Gln Gln Ala 
            100                 105                 110         


Ile Ala Gln Val Leu Thr Pro Ile Tyr Glu Glu Gln Phe His Asp His 
        115                 120                 125             


Ser Tyr Gly Phe Arg Pro Asn Arg Cys Ala Gln Gln Ala Ile Leu Thr 
    130                 135                 140                 


Ala Leu Asn Ile Met Asn Asp Gly Asn Asp Trp Ile Val Asp Ile Asp 
145                 150                 155                 160 


Leu Glu Lys Phe Phe Asp Thr Val Asn His Asp Lys Leu Met Thr Leu 
                165                 170                 175     


Ile Gly Arg Thr Ile Lys Asp Gly Asp Val Ile Ser Ile Val Arg Lys 
            180                 185                 190         


Tyr Leu Val Ser Gly Ile Met Ile Asp Asp Glu Tyr Glu Asp Ser Ile 
        195                 200                 205             


Val Gly Thr Pro Gln Gly Gly Asn Leu Ser Pro Leu Leu Ala Asn Ile 
    210                 215                 220                 


Met Leu Asn Glu Leu Asp Lys Glu Met Glu Lys Arg Gly Leu Asn Phe 
225                 230                 235                 240 


Val Arg Tyr Ala Asp Asp Cys Ile Ile Met Val Gly Ser Glu Met Ser 
                245                 250                 255     


Ala Asn Arg Val Met Arg Asn Ile Ser Arg Phe Ile Glu Glu Lys Leu 
            260                 265                 270         


Gly Leu Lys Val Asn Met Thr Lys Ser Lys Val Asp Arg Pro Ser Gly 
        275                 280                 285             


Leu Lys Tyr Leu Gly Phe Gly Phe Tyr Phe Asp Pro Arg Ala His Gln 
    290                 295                 300                 


Phe Lys Ala Lys Pro His Ala Lys Ser Val Ala Lys Phe Lys Lys Arg 
305                 310                 315                 320 


Met Lys Glu Leu Thr Cys Arg Ser Trp Gly Val Ser Asn Ser Tyr Lys 
                325                 330                 335     


Val Glu Lys Leu Asn Gln Leu Ile Arg Gly Trp Ile Asn Tyr Phe Lys 
            340                 345                 350         


Ile Gly Ser Met Lys Thr Leu Cys Lys Glu Leu Asp Ser Arg Ile Arg 
        355                 360                 365             


Tyr Arg Leu Arg Met Cys Ile Trp Lys Gln Trp Lys Thr Pro Gln Asn 
    370                 375                 380                 


Gln Glu Lys Asn Leu Val Lys Leu Gly Ile Asp Arg Asn Thr Ala Arg 
385                 390                 395                 400 


Arg Val Ala Tyr Thr Gly Lys Arg Ile Ala Tyr Val Cys Asn Lys Gly 
                405                 410                 415     


Ala Val Asn Val Ala Ile Ser Asn Lys Arg Leu Ala Ser Phe Gly Leu 
            420                 425                 430         


Ile Ser Met Leu Asp Tyr Tyr Ile Glu Lys Cys Val Thr Cys Ser Gly 
        435                 440                 445             


Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
    450                 455                 460                 


Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ser 
465                 470                 475                 480 


Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu Arg Lys 
                485                 490                 495     


Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly Ser Ala 
            500                 505                 510         


Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr Pro Glu 
        515                 520                 525             


Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp Ile Ala 
    530                 535                 540                 


Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp Ser Leu 
545                 550                 555                 560 


Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu Glu Tyr 
                565                 570                 575     


Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser Ala Ser 
            580                 585                 590         


Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr Tyr Asp 
        595                 600                 605             


Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His Asp Leu 
    610                 615                 620                 


Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu Ser Asn 
625                 630                 635                 640 


Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu Lys Glu 
                645                 650                 655     


Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu Ala Ile 
            660                 665                 670         


Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln Glu Ile 
        675                 680                 685             


Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln Val Tyr 
    690                 695                 700                 


Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile Ala Lys 
705                 710                 715                 720 


Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp Leu Lys 
                725                 730                 735     


Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys Gln Glu 
            740                 745                 750         


Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp Leu Trp 
        755                 760                 765             


Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys Ile Lys 
    770                 775                 780                 


Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln Phe Lys 
785                 790                 795                 800 


Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu Asn Asp 
                805                 810                 815     


Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr Ile Cys 
            820                 825                 830         


Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys Ala Trp 
        835                 840                 845             


Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu Cys Asp 
    850                 855                 860                 


Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile Leu Arg 
865                 870                 875                 880 


Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile Leu Ala 
                885                 890                 895     


Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln Lys Ala 
            900                 905                 910         


Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn Ala Val 
        915                 920                 925             


Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser Leu Asp 
    930                 935                 940                 


Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly Arg Trp 
945                 950                 955                 960 


Lys Lys Ala His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln Glu Ile 
                965                 970                 975     


Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg Thr Pro 
            980                 985                 990         


Arg Phe Gly Tyr His Leu Pro Lys  Leu Thr Asp Gln Thr  Ala Ile Arg 
        995                 1000                 1005             


Val Asn  Lys Lys His Val Lys  Ala Ala Lys Thr Glu  Ala Arg Ile 
    1010                 1015                 1020             


Arg Leu  Ala Ile Gln Gln Gly  Thr Leu Pro Val Ser  Asn Leu Lys 
    1025                 1030                 1035             


Ile Thr  Glu Ile Ser Ala Thr  Ile Asn Ser Lys Gly  Gln Val Arg 
    1040                 1045                 1050             


Ile Pro  Val Lys Phe Arg Val  Gly Arg Gln Lys Gly  Thr Leu Gln 
    1055                 1060                 1065             


Ile Gly  Asp Arg Phe Cys Gly  Tyr Asp Gln Asn Gln  Thr Ala Ser 
    1070                 1075                 1080             


His Ala  Tyr Ser Leu Trp Glu  Val Val Lys Glu Gly  Gln Tyr His 
    1085                 1090                 1095             


Lys Glu  Leu Arg Cys Arg Val  Arg Phe Ile Ser Ser  Gly Asp Ile 
    1100                 1105                 1110             


Val Ser  Ile Thr Glu Asn Arg  Gly Asn Gln Phe Asp  Gln Leu Ser 
    1115                 1120                 1125             


Tyr Glu  Gly Leu Ala Tyr Pro  Gln Tyr Ala Asp Trp  Arg Lys Lys 
    1130                 1135                 1140             


Ala Ser  Lys Phe Val Ser Leu  Trp Gln Ile Thr Lys  Lys Asn Lys 
    1145                 1150                 1155             


Lys Lys  Glu Ile Val Thr Val  Glu Ala Lys Glu Lys  Phe Asp Ala 
    1160                 1165                 1170             


Ile Cys  Lys Tyr Gln Pro Arg  Leu Tyr Lys Phe Asn  Lys Glu Tyr 
    1175                 1180                 1185             


Ala Tyr  Leu Leu Arg Asp Ile  Val Arg Gly Lys Ser  Leu Val Glu 
    1190                 1195                 1200             


Leu Gln  Gln Ile Arg Gln Glu  Ile Phe Arg Phe Ile  Glu Gln Asp 
    1205                 1210                 1215             


Cys Gly  Val Thr Arg Leu Gly  Ser Leu Ser Leu Ser  Thr Leu Glu 
    1220                 1225                 1230             


Thr Val  Lys Ala Val Lys Gly  Ile Ile Tyr Ser Tyr  Phe Ser Thr 
    1235                 1240                 1245             


Ala Leu  Asn Ala Ser Lys Asn  Asn Pro Ile Ser Asp  Glu Gln Arg 
    1250                 1255                 1260             


Lys Glu  Phe Asp Pro Glu Leu  Phe Ala Leu Leu Glu  Lys Leu Glu 
    1265                 1270                 1275             


Leu Ile  Arg Thr Arg Lys Lys  Lys Gln Lys Val Glu  Arg Ile Ala 
    1280                 1285                 1290             


Asn Ser  Leu Ile Gln Thr Cys  Leu Glu Asn Asn Ile  Lys Phe Ile 
    1295                 1300                 1305             


Arg Gly  Glu Gly Asp Leu Ser  Thr Thr Asn Asn Ala  Thr Lys Lys 
    1310                 1315                 1320             


Lys Ala  Asn Ser Arg Ser Met  Asp Trp Leu Ala Arg  Gly Val Phe 
    1325                 1330                 1335             


Asn Lys  Ile Arg Gln Leu Ala  Thr Met His Asn Ile  Thr Leu Phe 
    1340                 1345                 1350             


Gly Cys  Gly Ser Leu Tyr Thr  Ser His Gln Asp Pro  Leu Val His 
    1355                 1360                 1365             


Arg Asn  Pro Asp Lys Ala Met  Lys Cys Arg Trp Ala  Ala Ile Pro 
    1370                 1375                 1380             


Val Lys  Asp Ile Gly Asp Trp  Val Leu Arg Lys Leu  Ser Gln Asn 
    1385                 1390                 1395             


Leu Arg  Ala Lys Asn Arg Gly  Thr Gly Glu Tyr Tyr  His Gln Gly 
    1400                 1405                 1410             


Val Lys  Glu Phe Leu Ser His  Tyr Glu Leu Gln Asp  Leu Glu Glu 
    1415                 1420                 1425             


Glu Leu  Leu Lys Trp Arg Ser  Asp Arg Lys Ser Asn  Ile Pro Cys 
    1430                 1435                 1440             


Trp Val  Leu Gln Asn Arg Leu  Ala Glu Lys Leu Gly  Asn Lys Glu 
    1445                 1450                 1455             


Ala Val  Val Tyr Ile Pro Val  Arg Gly Gly Arg Ile  Tyr Phe Ala 
    1460                 1465                 1470             


Thr His  Lys Val Ala Thr Gly  Ala Val Ser Ile Val  Phe Asp Gln 
    1475                 1480                 1485             


Lys Gln  Val Trp Val Cys Asn  Ala Asp His Val Ala  Ala Ala Asn 
    1490                 1495                 1500             


Ile Ala  Leu Thr Gly Lys Gly  Ile Gly Arg Gln Ser  Ser Asp Glu 
    1505                 1510                 1515             


Glu Asn  Pro Asp Gly Gly Arg  Ile Lys Leu Gln Leu  Thr Ser Lys 
    1520                 1525                 1530             


Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1535                 1540                 1545             


<210>  224
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  224

Ser Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys 
1               5                   10                  15      


Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln 
            20                  25                  30          


Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro 
        35                  40                  45              


Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln 
    50                  55                  60                  


Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln 
65                  70                  75                  80  


Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn 
                85                  90                  95      


Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro 
            100                 105                 110         


Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro 
        115                 120                 125             


Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His 
    130                 135                 140                 


Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg 
145                 150                 155                 160 


Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro 
                165                 170                 175     


Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly 
            180                 185                 190         


Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu 
        195                 200                 205             


Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val 
    210                 215                 220                 


Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly 
225                 230                 235                 240 


Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser 
                245                 250                 255     


Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr 
            260                 265                 270         


Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr 
        275                 280                 285             


Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe 
    290                 295                 300                 


Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu 
305                 310                 315                 320 


Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn 
                325                 330                 335     


Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu 
            340                 345                 350         


Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu 
        355                 360                 365             


Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln 
    370                 375                 380                 


Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu 
385                 390                 395                 400 


Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala 
                405                 410                 415     


Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro 
            420                 425                 430         


Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro 
        435                 440                 445             


Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu 
    450                 455                 460                 


Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn 
465                 470                 475                 480 


Pro Ala Thr Leu Leu Pro 
                485     


<210>  225

<400>  225
000

<210>  226

<400>  226
000

<210>  227

<400>  227
000

<210>  228

<400>  228
000

<210>  229

<400>  229
000

<210>  230
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  230

Met Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly 
1               5                   10                  15      


Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala 
            20                  25                  30          


Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala 
        35                  40                  45              


Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile 
    50                  55                  60                  


Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys 
65                  70                  75                  80  


Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val 
                85                  90                  95      


Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn 
            100                 105                 110         


Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp 
        115                 120                 125             


Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro 
    130                 135                 140                 


Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln 
145                 150                 155                 160 


Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu 
                165                 170                 175     


Phe Asp Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg Ile Gln His 
            180                 185                 190         


Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala 
        195                 200                 205             


Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr 
    210                 215                 220                 


Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys 
225                 230                 235                 240 


Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg 
                245                 250                 255     


Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro 
            260                 265                 270         


Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Thr Ala Gly Phe Cys 
        275                 280                 285             


Arg Leu Trp Ile Pro Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro 
    290                 295                 300                 


Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys 
305                 310                 315                 320 


Ala Tyr Gln Glu Ile Leu Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly 
                325                 330                 335     


Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln 
            340                 345                 350         


Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg 
        355                 360                 365             


Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp 
    370                 375                 380                 


Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp 
385                 390                 395                 400 


Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Leu Ala Pro His 
                405                 410                 415     


Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Asn 
            420                 425                 430         


Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val 
        435                 440                 445             


Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu 
    450                 455                 460                 


Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala 
465                 470                 475                 480 


His Gly Thr Arg Pro Asp Leu 
                485         


<210>  231
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  231

Met Leu Gln Leu Gly His Leu Glu Glu Ser Asn Ser Pro Trp Asn Thr 
1               5                   10                  15      


Pro Val Phe Val Ile Lys Lys Lys Ser Gly Lys Trp Arg Leu Leu Gln 
            20                  25                  30          


Asp Leu Arg Ala Val Asn Ala Thr Met His Asp Met Gly Ala Leu Gln 
        35                  40                  45              


Pro Gly Leu Pro Ser Pro Val Ala Val Pro Lys Gly Trp Glu Ile Ile 
    50                  55                  60                  


Ile Ile Asp Leu Gln Asp Cys Phe Phe Asn Ile Lys Leu His Pro Glu 
65                  70                  75                  80  


Asp Cys Lys Arg Phe Ala Phe Ser Val Pro Ser Pro Asn Phe Lys Arg 
                85                  90                  95      


Pro Tyr Gln Arg Phe Gln Trp Lys Val Leu Pro Gln Gly Met Lys Asn 
            100                 105                 110         


Ser Pro Thr Leu Cys Gln Lys Phe Val Asp Lys Ala Ile Leu Thr Val 
        115                 120                 125             


Arg Asp Lys Tyr Gln Asp Ser Tyr Ile Val His Tyr Met Asp Asp Ile 
    130                 135                 140                 


Leu Leu Ala His Pro Ser Arg Ser Ile Val Asp Glu Ile Leu Thr Ser 
145                 150                 155                 160 


Met Ile Gln Ala Leu Asn Lys His Gly Leu Val Val Ser Thr Glu Lys 
                165                 170                 175     


Ile Gln Lys Tyr Asp Asn Leu Lys Tyr Leu Gly Thr His Ile Gln Gly 
            180                 185                 190         


Asp Ser Val Ser Tyr Gln Lys Leu Gln Ile Arg Thr Asp Lys Leu Arg 
        195                 200                 205             


Thr Leu Asn Asp Phe Gln Lys Leu Leu Gly Asn Ile Asn Trp Ile Arg 
    210                 215                 220                 


Pro Phe Leu Lys Leu Thr Thr 
225                 230     


<210>  232
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  232

Met Asp Thr Ser Asn Leu Met Glu Gln Ile Leu Ser Ser Asp Asn Leu 
1               5                   10                  15      


Asn Arg Ala Tyr Leu Gln Val Val Arg Asn Lys Gly Ala Glu Gly Val 
            20                  25                  30          


Asp Gly Met Lys Tyr Thr Glu Leu Lys Glu His Leu Ala Lys Asn Gly 
        35                  40                  45              


Glu Thr Ile Lys Gly Gln Leu Arg Thr Arg Lys Tyr Lys Pro Gln Pro 
    50                  55                  60                  


Ala Arg Arg Val Glu Ile Pro Lys Pro Asp Gly Gly Val Arg Asn Leu 
65                  70                  75                  80  


Gly Val Pro Thr Val Thr Asp Arg Phe Ile Gln Gln Ala Ile Ala Gln 
                85                  90                  95      


Val Leu Thr Pro Ile Tyr Glu Glu Gln Phe His Asp His Ser Tyr Gly 
            100                 105                 110         


Phe Arg Pro Asn Arg Cys Ala Gln Gln Ala Ile Leu Thr Ala Leu Asn 
        115                 120                 125             


Ile Met Asn Asp Gly Asn Asp Trp Ile Val Asp Ile Asp Leu Glu Lys 
    130                 135                 140                 


Phe Phe Asp Thr Val Asn His Asp Lys Leu Met Thr Leu Ile Gly Arg 
145                 150                 155                 160 


Thr Ile Lys Asp Gly Asp Val Ile Ser Ile Val Arg Lys Tyr Leu Val 
                165                 170                 175     


Ser Gly Ile Met Ile Asp Asp Glu Tyr Glu Asp Ser Ile Val Gly Thr 
            180                 185                 190         


Pro Gln Gly Gly Asn Leu Ser Pro Leu Leu Ala Asn Ile Met Leu Asn 
        195                 200                 205             


Glu Leu Asp Lys Glu Met Glu Lys Arg Gly Leu Asn Phe Val Arg Tyr 
    210                 215                 220                 


Ala Asp Asp Cys Ile Ile Met Val Gly Ser Glu Met Ser Ala Asn Arg 
225                 230                 235                 240 


Val Met Arg Asn Ile Ser Arg Phe Ile Glu Glu Lys Leu Gly Leu Lys 
                245                 250                 255     


Val Asn Met Thr Lys Ser Lys Val Asp Arg Pro Ser Gly Leu Lys Tyr 
            260                 265                 270         


Leu Gly Phe Gly Phe Tyr Phe Asp Pro Arg Ala His Gln Phe Lys Ala 
        275                 280                 285             


Lys Pro His Ala Lys Ser Val Ala Lys Phe Lys Lys Arg Met Lys Glu 
    290                 295                 300                 


Leu Thr Cys Arg Ser Trp Gly Val Ser Asn Ser Tyr Lys Val Glu Lys 
305                 310                 315                 320 


Leu Asn Gln Leu Ile Arg Gly Trp Ile Asn Tyr Phe Lys Ile Gly Ser 
                325                 330                 335     


Met Lys Thr Leu Cys Lys Glu Leu Asp Ser Arg Ile Arg Tyr Arg Leu 
            340                 345                 350         


Arg Met Cys Ile Trp Lys Gln Trp Lys Thr Pro Gln Asn Gln Glu Lys 
        355                 360                 365             


Asn Leu Val Lys Leu Gly Ile Asp Arg Asn Thr Ala Arg Arg Val Ala 
    370                 375                 380                 


Tyr Thr Gly Lys Arg Ile Ala Tyr Val Cys Asn Lys Gly Ala Val Asn 
385                 390                 395                 400 


Val Ala Ile Ser Asn Lys Arg Leu Ala Ser Phe Gly Leu Ile Ser Met 
                405                 410                 415     


Leu Asp Tyr Tyr Ile Glu Lys Cys Val Thr Cys 
            420                 425         


<210>  233
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  233

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Leu Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Met Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Ile Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg His Gln Ser His 
    370                 375                 380                 


Glu Gly Gly Tyr Ile Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Arg Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Leu Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Ile Ala Trp Gly Arg Glu Tyr Leu Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Leu Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Lys Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Val Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Lys Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Arg 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  234
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  234

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Leu Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Met Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Ile Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asp Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg His Gln Ser His 
    370                 375                 380                 


Glu Gly Gly Tyr Ile Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Arg Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Leu Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Ile Ala Trp Gly Arg Glu Tyr Leu Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Leu Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Lys Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Val Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Lys Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Arg 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  235
<211>  774
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  235

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Leu Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Ser Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Ser Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Met Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Ile Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Leu Asp Ile Gly Thr 
    130                 135                 140                 


Pro Cys His Glu Gly Glu Val Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Thr Arg Val Ile Thr Trp Arg Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Leu Ser Thr Glu Arg Glu Met Ile Gln 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Thr Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Val Asn Leu Pro Ile 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Met Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg His Gln Ser His 
    370                 375                 380                 


Glu Gly Gly Tyr Ile Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Arg Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Leu Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Ile Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Leu Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Glu Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Leu Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Lys Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Val Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Tyr Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Trp Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Arg 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  236
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  236

Met Asp His Leu Leu Leu Lys Thr Gln Thr Gln Thr Glu Gln Val Met 
1               5                   10                  15      


Asn Val Thr Asn Pro Asn Ser Ile Tyr Ile Lys Gly Arg Leu Tyr Phe 
            20                  25                  30          


Lys Gly Tyr Lys Lys Ile Glu Leu His Cys Phe Val Asp Thr Gly Ala 
        35                  40                  45              


Ser Leu Cys Ile Ala Ser Lys Phe Val Ile Pro Glu Glu His Trp Val 
    50                  55                  60                  


Asn Ala Glu Arg Pro Ile Met Val Lys Ile Ala Asp Gly Ser Ser Ile 
65                  70                  75                  80  


Thr Ile Ser Lys Val Cys Lys Asp Ile Asp Leu Ile Ile Ala Gly Glu 
                85                  90                  95      


Ile Phe Arg Ile Pro Thr Val Tyr Gln Gln Glu Ser Gly Ile Asp Phe 
            100                 105                 110         


Ile Ile Gly Asn Asn Phe Cys Gln Leu Tyr Glu Pro Phe Ile Gln Phe 
        115                 120                 125             


Thr Asp Arg Val Ile Phe Thr Lys Asn Lys Ser Tyr Pro Val His Ile 
    130                 135                 140                 


Ala Lys Leu Thr Arg Ala Val Arg Val Gly Thr Glu Gly Phe Leu Glu 
145                 150                 155                 160 


Ser Met Lys Lys Arg Ser Lys Thr Gln Gln Pro Glu Pro Val Asn Ile 
                165                 170                 175     


Ser Thr Asn Lys Ile Glu Asn Pro Leu Glu Glu Ile Ala Ile Leu Ser 
            180                 185                 190         


Glu Gly Arg Arg Leu Ser Glu Glu Lys Leu Phe Ile Thr Gln Gln Arg 
        195                 200                 205             


Met Gln Lys Ile Glu Glu Leu Leu Glu Lys Val Cys Ser Glu Asn Pro 
    210                 215                 220                 


Leu Asp Pro Asn Lys Thr Lys Gln Trp Met Lys Ala Ser Ile Lys Leu 
225                 230                 235                 240 


Ser Asp Pro Ser Lys Ala Ile Lys Val Lys Pro Met Lys Tyr Ser Pro 
                245                 250                 255     


Met Asp Arg Glu Glu Phe Asp Lys Gln Ile Lys Glu Leu Leu Asp Leu 
            260                 265                 270         


Lys Val Ile Lys Pro Ser Lys Ser Pro His Met Ala Pro Ala Phe Leu 
        275                 280                 285             


Val Asn Asn Glu Ala Glu Lys Arg Arg Gly Lys Lys Arg Met Val Val 
    290                 295                 300                 


Asn Tyr Lys Ala Met Asn Lys Ala Thr Val Gly Asp Ala Tyr Asn Leu 
305                 310                 315                 320 


Pro Asn Lys Asp Glu Leu Leu Thr Leu Ile Arg Gly Lys Lys Ile Phe 
                325                 330                 335     


Ser Ser Phe Asp Cys Lys Ser Gly Phe Trp Gln Val Leu Leu Asp Gln 
            340                 345                 350         


Glu Ser Arg Pro Leu Thr Ala Phe Thr Cys Pro Gln Gly His Tyr Glu 
        355                 360                 365             


Trp Asn Val Val Pro Phe Gly Leu Lys Gln Ala Pro Ser Ile Phe Gln 
    370                 375                 380                 


Arg His Met Asp Glu Ala Phe Arg Val Phe Arg Lys Phe Cys Cys Val 
385                 390                 395                 400 


Tyr Val Asp Asp Ile Leu Val Phe Ser Asn Asn Glu Glu Asp His Leu 
                405                 410                 415     


Leu His Val Ala Met Ile Leu Gln Lys Cys Asn Gln His Gly Ile Ile 
            420                 425                 430         


Leu Ser Lys Lys Lys Ala Gln Leu Phe Lys Lys Lys Ile Asn Phe Leu 
        435                 440                 445             


Gly Leu Glu Ile Asp Glu Gly Thr His Lys Pro Gln Gly His Ile Leu 
    450                 455                 460                 


Glu His Ile Asn Lys Phe Pro Asp Thr Leu Glu Asp Lys Lys Gln Leu 
465                 470                 475                 480 


Gln Arg Phe Leu Gly Ile Leu Thr Tyr Ala Ser Asp Tyr Ile Pro Lys 
                485                 490                 495     


Leu Ala Gln Ile Arg Lys Pro Leu Gln Ala Lys Leu Lys Glu Asn Val 
            500                 505                 510         


Pro Trp Arg Trp Thr Lys Glu Asp Thr Leu Tyr Met Gln Lys Val Lys 
        515                 520                 525             


Lys Asn Leu Gln Gly Phe Pro Pro Leu His His Pro Leu Pro Glu Glu 
    530                 535                 540                 


Lys Leu Ile Ile Glu Thr Asp Ala Ser Asp Asp Tyr Trp Gly Gly Met 
545                 550                 555                 560 


Leu Lys Ala Ile Lys Ile Asn Glu Gly Thr Asn Thr Glu Leu Ile Cys 
                565                 570                 575     


Arg Tyr Ala Ser Gly Ser Phe Lys Ala Ala Glu Lys Asn Tyr His Ser 
            580                 585                 590         


Asn Asp Lys Glu Thr Leu Ala Val Ile Asn Thr Ile Lys Lys Phe Ser 
        595                 600                 605             


Ile Tyr Leu Thr Pro Val His Phe Leu Ile Arg Thr Asp Asn Thr His 
    610                 615                 620                 


Phe Lys Ser Phe Val Asn Leu Asn Tyr Lys Gly Asp Ser Lys Leu Gly 
625                 630                 635                 640 


Arg Asn Ile Arg Trp Gln Ala Trp Leu Ser His Tyr Ser Phe Asp Val 
                645                 650                 655     


Glu His Ile Lys Gly Thr Asp Asn His Phe Ala Asp Phe Leu Ser Arg 
            660                 665                 670         


Glu Phe Asn Lys Val Asn Ser Ser Gly Gly Ser 
        675                 680             


<210>  237
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  237

Met Gly Ile His Gly Val Pro Ala Ala Met Lys Ser Ala Glu Tyr Leu 
1               5                   10                  15      


Asn Thr Phe Arg Leu Arg Asn Leu Gly Leu Pro Val Met Asn Asn Leu 
            20                  25                  30          


His Asp Met Ser Lys Ala Thr Arg Ile Ser Val Glu Thr Leu Arg Leu 
        35                  40                  45              


Leu Ile Tyr Thr Ala Asp Phe Arg Tyr Arg Ile Tyr Thr Val Glu Lys 
    50                  55                  60                  


Lys Gly Pro Glu Lys Arg Met Arg Thr Ile Tyr Gln Pro Ser Arg Glu 
65                  70                  75                  80  


Leu Lys Ala Leu Gln Gly Trp Val Leu Arg Asn Ile Leu Asp Lys Leu 
                85                  90                  95      


Ser Ser Ser Pro Phe Ser Ile Gly Phe Glu Lys His Gln Ser Ile Leu 
            100                 105                 110         


Asn Asn Ala Thr Pro His Ile Gly Ala Asn Phe Ile Leu Asn Ile Asp 
        115                 120                 125             


Leu Glu Asp Phe Phe Pro Ser Leu Thr Ala Asn Lys Val Phe Gly Val 
    130                 135                 140                 


Phe His Ser Leu Gly Tyr Asn Arg Leu Ile Ser Ser Val Leu Thr Lys 
145                 150                 155                 160 


Ile Cys Cys Tyr Lys Asn Leu Leu Pro Gln Gly Ala Pro Ser Ser Pro 
                165                 170                 175     


Lys Leu Ala Asn Leu Ile Cys Ser Lys Leu Asp Tyr Arg Ile Gln Gly 
            180                 185                 190         


Tyr Ala Gly Ser Arg Gly Leu Ile Tyr Thr Arg Tyr Ala Asp Asp Leu 
        195                 200                 205             


Thr Leu Ser Ala Gln Ser Met Lys Lys Val Val Lys Ala Arg Asp Phe 
    210                 215                 220                 


Leu Phe Ser Ile Ile Pro Ser Glu Gly Leu Val Ile Asn Ser Lys Lys 
225                 230                 235                 240 


Thr Cys Ile Ser Gly Pro Arg Ser Gln Arg Lys Val Thr Gly Leu Val 
                245                 250                 255     


Ile Ser Gln Glu Lys Val Gly Ile Gly Arg Glu Lys Tyr Lys Glu Ile 
            260                 265                 270         


Arg Ala Lys Ile His His Ile Phe Cys Gly Lys Ser Ser Glu Ile Glu 
        275                 280                 285             


His Val Arg Gly Trp Leu Ser Phe Ile Leu Ser Val Asp Ser Lys Ser 
    290                 295                 300                 


His Arg Arg Leu Ile Thr Tyr Ile Ser Lys Leu Glu Lys Lys Tyr Gly 
305                 310                 315                 320 


Lys Asn Pro Leu Asn Lys Ala Lys Thr 
                325                 


<210>  238
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  238

Met Glu Lys Glu Gly Gln Leu Glu Glu Ala Pro Pro Thr Asn Pro Tyr 
1               5                   10                  15      


Asn Thr Pro Thr Phe Ala Ile Lys Lys Lys Asp Lys Asn Lys Trp Arg 
            20                  25                  30          


Met Leu Ile Asp Phe Arg Glu Leu Asn Lys Val Thr Gln Asp Phe Thr 
        35                  40                  45              


Glu Ile Gln Leu Gly Ile Pro His Pro Ala Gly Leu Ala Lys Lys Arg 
    50                  55                  60                  


Arg Ile Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser Ile Pro Leu 
65                  70                  75                  80  


His Glu Asp Phe Arg Pro Tyr Thr Ala Phe Thr Leu Pro Ser Val Asn 
                85                  90                  95      


Asn Ala Glu Pro Gly Lys Arg Tyr Ile Tyr Lys Val Leu Pro Gln Gly 
            100                 105                 110         


Trp Lys Gly Ser Pro Ala Ile Phe Gln His Thr Met Arg Gln Val Leu 
        115                 120                 125             


Glu Pro Phe Arg Lys Ala Asn Lys Asp Val Ile Ile Ile Gln Tyr Met 
    130                 135                 140                 


Asp Asp Ile Leu Ile Ala Ser Asp Arg Thr Asp Leu Glu His Asp Arg 
145                 150                 155                 160 


Val Val Leu Gln Leu Lys Glu Leu Leu Asn Gly Leu Gly Phe Ser Thr 
                165                 170                 175     


Pro Asp Glu Lys Phe Gln Lys Asp Pro Pro Ile His Trp Met Gly Tyr 
            180                 185                 190         


Glu Leu Trp Pro Thr Lys Trp Lys Leu Gln Lys Ile Gln Leu Pro Gln 
        195                 200                 205             


Lys Glu Ile Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Val Leu 
    210                 215                 220                 


Asn Trp Ala Ala Gln Leu Tyr Pro Gly Ile Lys 
225                 230                 235 


<210>  239
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  239

Met Glu Glu Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu Asn Pro Tyr 
1               5                   10                  15      


Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg 
            20                  25                  30          


Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp 
        35                  40                  45              


Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys 
    50                  55                  60                  


Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro Leu 
65                  70                  75                  80  


Asp Glu Ser Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn 
                85                  90                  95      


Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly 
            100                 105                 110         


Trp Lys Gly Ser Pro Ala Ile Phe Gln Ser Ser Met Thr Lys Ile Leu 
        115                 120                 125             


Glu Pro Phe Arg Ile Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met 
    130                 135                 140                 


Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Thr 
145                 150                 155                 160 


Lys Ile Glu Glu Leu Arg Ala His Leu Leu Ser Trp Gly Phe Thr Thr 
                165                 170                 175     


Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr 
            180                 185                 190         


Glu Leu His Pro Asp Arg Trp Thr Val Gln Pro Ile Asp Leu Pro Glu 
        195                 200                 205             


Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu 
    210                 215                 220                 


Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys 
225                 230                 235 


<210>  240
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  240

Met Pro Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly 
1               5                   10                  15      


Met Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile 
            20                  25                  30          


Lys Ala Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile 
        35                  40                  45              


Ser Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile 
    50                  55                  60                  


Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu 
65                  70                  75                  80  


Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro 
                85                  90                  95      


His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu Asp Val 
            100                 105                 110         


Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr 
        115                 120                 125             


Thr Ala Phe Thr Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg 
    130                 135                 140                 


Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile 
145                 150                 155                 160 


Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn 
                165                 170                 175     


Pro Asp Ile Val Ile Tyr Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser 
            180                 185                 190         


Asp Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln 
        195                 200                 205             


His Leu Leu Arg Trp Gly Leu Thr Thr Pro Asp Lys Lys His Gln Lys 
    210                 215                 220                 


Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp 
225                 230                 235                 240 


Thr Val Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn 
                245                 250                 255     


Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr 
            260                 265                 270         


Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys 
        275                 280                 285             


Ala Leu Thr Glu Val Ile Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu 
    290                 295                 300                 


Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr 
305                 310                 315                 320 


Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly 
                325                 330                 335     


Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr 
            340                 345                 350         


Gly Lys Tyr Ala Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln 
        355                 360                 365             


Leu Thr Glu Ala Val Gln Lys Ile Thr Thr Glu Ser Ile Val Ile Trp 
    370                 375                 380                 


Gly Lys Thr Pro Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu 
385                 390                 395                 400 


Thr Trp Trp Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu 
                405                 410                 415     


Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys 
            420                 425                 430         


Glu Pro Ile Val Gly Ala Glu Thr Phe 
        435                 440     


<210>  241
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  241
aauagcggcc cuaagaaauc cgucuuucau ugacgg                                 36


<210>  242
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  242
auuggaacug gcgagaaauc cgucuuucau ugacgg                                 36


<210>  243
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  243
ccagcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  244
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  244
cggcgcucga auaggaaauc cgucuuucau ugacgg                                 36


<210>  245
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  245
guggcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  246
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  246
guugcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  247
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  247
guugcaaugc cuaagaaauc cgucuuucau ugacgg                                 36


<210>  248
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  248
gggaagtggt tggtcagcat                                                   20


<210>  249
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  249
gggaagtggt tgcgaggcat                                                   20


<210>  250
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  250
gggaagtggt tgagcggtca                                                   20


<210>  251
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  251
gggaagtggt tggcat                                                       16


<210>  252
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  252
gagccagtgt tgctagtcaa                                                   20


<210>  253
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  253
gagccagtgt tgcgagtcaa                                                   20


<210>  254
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  254
gagccagtgt tgagcgctag                                                   20


<210>  255
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  255
gagccagtgt tgtcaa                                                       16


<210>  256
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  256
ttaaactctc catggaccag                                                   20


<210>  257
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  257
ttaaactctc cacgagccag                                                   20


<210>  258
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  258
ttaaactctc caagcgtgga                                                   20


<210>  259
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  259
ttaaactctc caccag                                                       16


