                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  COMPOSITIONS AND METHODS OF MODULATING RNA AND PROTEIN 
       INTERACTIONS

<130>  15670-0353WO1

<150>  US 63/196,005
<151>  2021-06-02

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  1
ucuacagcuu cugauaauca accaa                                             25


<210>  2
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  2
uugguugauu aucagaagcu guagaaa                                           27


<210>  3
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  3
cuugcuacca guauuuagaa gccaa                                             25


<210>  4
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  4
uuggcuucua aauacuggua gcaagau                                           27


<210>  5
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  5
accuuccaug ucaagauuca gcuag                                             25


<210>  6
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  6
cuagcugaau cuugacaugg aagguuu                                           27


<210>  7
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  7
aaaucauguu ggagaucucu auugt                                             25


<210>  8
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  8
acaauagaga ucuccaacau gauuuca                                           27


<210>  9
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  9
aaggaaucca guugaauaca auuct                                             25


<210>  10
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  10
agaauuguau ucaacuggau uccuugu                                           27


<210>  11
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  11
aguaugaagu caucgguaau uacta                                             25


<210>  12
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  12
uaguaauuac cgaugacuuc auacuga                                           27


<210>  13
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  13
cgguuugaga auguuccuau aauaa                                             25


<210>  14
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  14
uuauuauagg aacauucuca aaccgca                                           27


<210>  15
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  15
gagccuuuag uuuucaucca uguac                                             25


<210>  16
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  16
guacauggau gaaaacuaaa ggcucga                                           27


<210>  17
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  17
agcugagaug uuccuuagua aucat                                             25


<210>  18
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  18
augauuacua aggaacaucu cagcugu                                           27


<210>  19
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  19
ggcucagcug auaaacauga auctg                                             25


<210>  20
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  20
cagauucaug uuuaucagcu gagccaa                                           27


<210>  21
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  21
gaauggaaau guauugguaa agcta                                             25


<210>  22
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  22
uagcuuuacc aauacauuuc cauuccc                                           27


<210>  23
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  23
agucugaaug gaaggauacu aauta                                             25


<210>  24
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  24
uaauuaguau ccuuccauuc agacucg                                           27


<210>  25
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  25
guucugaagu cuaagauauu uuuca                                             25


<210>  26
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  26
ugaaaaauau cuuagacuuc agaacag                                           27


<210>  27
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  27
aacuacaccu ggauuuuucc aaaca                                             25


<210>  28
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  28
uguuuggaaa aauccaggug uaguugc                                           27


<210>  29
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  29
agugauguuu ggaaucgauc augct                                             25


<210>  30
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  30
ugucacuaca aaccuuagcu aguacga                                           27


<210>  31
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  31
gagcuuuuug gaaggauaau ucuga                                             25


<210>  32
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  32
ucagaauuau ccuuccaaaa agcucaa                                           27


<210>  33
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  33
ggacaguggu aaagagcuga aaatt                                             25


<210>  34
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  34
aauuuucagc ucuuuaccac uguccaa                                           27


<210>  35
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  siRNA +strand; Nucleotides at residues 1-23 are ribonucleotides.

<400>  35
ggucaagaug uacugcuauu uautg                                             25


<210>  36
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  siRNA -strand; Nucleotides at residues 1-27 are ribonucleotides.

<400>  36
caauaaauag caguacaucu ugaccuu                                           27


<210>  37
<211>  26
<212>  RNA
<213>  Artificial

<220>
<223>  Scrambled Negative Control DsiRNA; Nucleotides at residues 1-23 are ribonucleotides; n = 5' phosphorylated


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or u

<400>  37
ncuuccucuc uuucucuccc uuguga                                            26


<210>  38
<211>  27
<212>  RNA
<213>  Artificial

<220>
<223>  Scrambled Negative Control DsiRNA; Nucleotides at residues 1-27 are ribonucleotides.

<400>  38
ucacaaggga gagaaagaga ggaagga                                           27


<210>  39
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  TYE 563 Transfection Control DsiRNA; Nucleotides at residues 3-25 are ribonucleotides; n = 5' TYE563 modification


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<400>  39
ntccuuccuc ucuuucucuc ccuuguga                                          28


<210>  40
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  TYE 563 Transfection Control DsiRNA; Nucleotides at residues 3-25 are ribonucleotides; n = 5' TYE563 modification


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, t or u

<400>  40
ntcacaaggg agagaaagag aggaagga                                          28


<210>  41
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Single stranded DNA oligonucleotide

<400>  41
taatacgact cactataggg cgaaaacgcc c                                      31


<210>  42
<211>  88
<212>  DNA
<213>  Artificial

<220>
<223>  Single stranded DNA oligonucleotide

<400>  42
actatagggc gaaaacgccc cattttatta tgtatggaaa agttatgtgc atgttgtaga       60

cggttgtaat tcatcaactt gtatgatg                                          88


<210>  43
<211>  85
<212>  DNA
<213>  Artificial

<220>
<223>  Single stranded DNA oligonucleotide

<400>  43
aacaccatta acaatagttg tacattcgac tcttgttgct ctattacgtt tgtaacacat       60

catacaagtt gatgaattac aaccg                                             85


<210>  44
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Single stranded DNA oligonucleotide

<400>  44
aacaccatta acaatagttg tacattcg                                          28


<210>  45
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Single stranded DNA oligonucleotide

<400>  45
actatagggc gaaaacgccc gaattttatc atgactgaac tgtttttgtg tcccaaaaat       60

agtgctacat taggaaaata attaagatta                                        90


<210>  46
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Single stranded DNA oligonucleotide

<400>  46
ccctcctgat aagtaaaccc tagtactaaa taacatatta actccaattc agccgtaatc       60

ttaattattt tcctaatgta gcactatttt                                        90


<210>  47
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Single stranded DNA oligonucleotide

<400>  47
ccctcctgat aagtaaaccc tag                                               23


<210>  48
<211>  156
<212>  DNA
<213>  Artificial

<220>
<223>  Double stranded DNA, PCR product

<400>  48
taatacgact cactataggg cgaaaacgcc ccattttatt atgtatggaa aagttatgtg       60

catgttgtag acggttgtaa ttcatcaact tgtatgatgt gttacaaacg taatagagca      120

acaagagtcg aatgtacaac tattgttaat ggtgtt                                156


<210>  49
<211>  176
<212>  DNA
<213>  Artificial

<220>
<223>  Double stranded DNA, PCR product

<400>  49
taatacgact cactataggg cgaaaacgcc cactataggg cgaaaacgcc cgaattttat       60

catgactgaa ctgtttttgt gtcccaaaaa tagtgctaca ttaggaaaat aattaagatt      120

acggctgaat tggagttaat atgttattta gtactagggt ttacttatca ggaggg          176


<210>  50
<211>  139
<212>  RNA
<213>  Artificial

<220>
<223>  In vitro transcribed RNA

<400>  50
gggcgaaaac gccccauuuu auuauguaug gaaaaguuau gugcauguug uagacgguug       60

uaauucauca acuuguauga uguguuacaa acguaauaga gcaacaagag ucgaauguac      120

aacuauuguu aaugguguu                                                   139


<210>  51
<211>  139
<212>  RNA
<213>  Artificial

<220>
<223>  In vitro transcribed RNA

<400>  51
gggcgaaaac gcccgaauuu uaucaugacu gaacuguuuu ugugucccaa aaauagugcu       60

acauuaggaa aauaauuaag auuacggcug aauuggaguu aauauguuau uuaguacuag      120

gguuuacuua ucaggaggg                                                   139


<210>  52
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  LNA7472-7493; Nucleotides at 1-6, 8-10, 12, 14-16, 18-22 are locked nucleic acid bases.

<400>  52
tacaagttga tgaattacaa cc                                                22


<210>  53
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Scrambled LNA; Nucleotides at 1-3, 6, 9, 12, 14, 17-19 are locked nucleic acid bases.

<400>  53
gcggcacgtt gcgagtact                                                    19


