                               SEQUENCE LISTING

<110> KORRO BIO, INC.
 
<120> METHODS FOR RESTORING PROTEIN FUNCTION USING ADAR

<130> 131522-02020

<140> PCT/US2022/031511
<141> 2022-05-31

<150> 63/195,370
<151> 2021-06-01

<160> 85    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ggugaauagu auaacaauau                                                   20


<210> 2
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
auguuguuau aguauccacc                                                   20


<210> 3
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210> 4
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ggugaagagg agaacaauau                                                   20


<210> 5
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
auguuguucu cgucuccacc                                                   20


<210> 6
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210> 7
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ggugucgaga agaggagaac aauau                                             25


<210> 8
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
auguuguucu cgucuccucg acacc                                             25


<210> 9
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210> 10
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
ggguggaaua guauaacaau au                                                22


<210> 11
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
auguuguuau aguaucccac cu                                                22


<210> 12
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 13
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
guggaauagu auaacaauau                                                   20


<210> 14
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
auguuguuau aguaucccac                                                   20


<210> 15
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210> 16
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ggugucgaga auaguauaac aauau                                             25


<210> 17
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
auguuguuau aguauccucg acacc                                             25


<210> 18
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210> 19
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
ggguggaaua guauaacaau au                                                22


<210> 20
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
auguuguuau aguaucccac cu                                                22


<210> 21
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 22
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
ggguggaaua guauacca                                                     18


<210> 23
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ugguauagua ucccaccu                                                     18


<210> 24
<211> 40
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210> 25
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
guggguggaa uaguauacca                                                   20


<210> 26
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
ugguauagua ucccaccuac                                                   20


<210> 27
<211> 44
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
uggguggaau aguauacca                                                    19


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
ugguauagua ucccaccua                                                    19


<210> 30
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210> 31
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gguggaauag uauacca                                                      17


<210> 32
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ugguauagua ucccacc                                                      17


<210> 33
<211> 38
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210> 34
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
guggaauagu auacca                                                       16


<210> 35
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
ugguauagua ucccac                                                       16


<210> 36
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210> 37
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210> 38
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210> 39
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210> 40
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (5)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (27)..(28)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (32)..(32)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (34)..(35)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (37)..(41)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (43)..(49)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (52)..(52)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (54)..(55)
<223> 2'-O-methyl nucleotide

<400> 40
nnngnngaga agaggagaan aanangnnaa angnngnnnn ngnnnnnnng anann            55


<210> 41
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 42
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210> 43
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210> 44
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 45
<211> 40
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210> 46
<211> 44
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210> 47
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210> 48
<211> 38
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210> 49
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210> 50
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
acatgaggat cacccatgt                                                    19


<210> 51
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RFGF peptide sequence

<400> 51
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 52
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RFGF analogue peptide sequence

<400> 52
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 53
<211> 13
<212> PRT
<213> Human immunodeficiency virus 1

<400> 53
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 54
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 54
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 55
<211> 2136
<212> DNA
<213> Homo sapiens

<400> 55
atggaacaaa aacttatttc tgaagaagat ctggatatag aagatgaaga aaacatgagt       60

tccagcagca ctgatgtgaa ggaaaaccgc aatctggaca acgtgtcccc caaggatggc      120

agcacacctg ggcctggcga gggctctcag ctctccaatg ggggtggtgg tggccccggc      180

agaaagcggc ccctggagga gggcagcaat ggccactcca agtaccgcct gaagaaaagg      240

aggaaaacac cagggcccgt cctccccaag aacgccctga tgcagctgaa tgagatcaag      300

cctggtttgc agtacacact cctgtcccag actgggcccg tgcacgcgcc tttgtttgtc      360

atgtctgtgg aggtgaatgg ccaggttttt gagggctctg gtcccacaaa gaaaaaggca      420

aaactccatg ctgctgagaa ggccttgagg tctttcgttc agtttcctaa tgcctctgag      480

gcccacctgg ccatggggag gaccctgtct gtcaacacgg acttcacatc tgaccaggcc      540

gacttccctg acacgctctt caatggtttt gaaactcctg acaaggcgga gcctcccttt      600

tacgtgggct ccaatgggga tgactccttc agttccagcg gggacctcag cttgtctgct      660

tccccggtgc ctgccagcct agcccagcct cctctccctg tcttaccacc attcccaccc      720

ccgagtggga agaatcccgt gatgatcttg aacgaactgc gcccaggact caagtatgac      780

ttcctctccg agagcgggga gagccatgcc aagagcttcg tcatgtctgt ggtcgtggat      840

ggtcagttct ttgaaggctc ggggagaaac aagaagcttg ccaaggcccg ggctgcgcag      900

tctgccctgg ccgccatttt taacttgcac ttggatcaga cgccatctcg ccagcctatt      960

cccagtgagg gtcttcagct gcatttaccg caggttttag ctgacgctgt ctcacgcctg     1020

gtcctgggta agtttggtga cctgaccgac aacttctcct cccctcacgc tcgcagaaaa     1080

gtgctggctg gagtcgtcat gacaacaggc acagatgtta aagatgccaa ggtgataagt     1140

gtttctacag gaacaaaatg tattaatggt gaatacatga gtgatcgtgg ccttgcatta     1200

aatgactgcc atgcagaaat aatatctcgg agatccttgc tcagatttct ttatacacaa     1260

cttgagcttt acttaaataa caaagatgat caaaaaagat ccatctttca gaaatcagag     1320

cgaggggggt ttaggctgaa ggagaatgtc cagtttcatc tgtacatcag cacctctccc     1380

tgtggagatg ccagaatctt ctcaccacat gagccaatcc tggaagaacc agcagataga     1440

cacccaaatc gtaaagcaag aggacagcta cggaccaaaa tagagtctgg tgaggggacg     1500

attccagtgc gctccaatgc gagcatccaa acgtgggacg gggtgctgca aggggagcgg     1560

ctgctcacca tgtcctgcag tgacaagatt gcacgctgga acgtggtggg catccaggga     1620

tccctgctca gcattttcgt ggagcccatt tacttctcga gcatcatcct gggcagcctt     1680

taccacgggg accacctttc cagggccatg taccagcgga tctccaacat agaggacctg     1740

ccacctctct acaccctcaa caagcctttg ctcagtggca tcagcaatgc agaagcacgg     1800

cagccaggga aggcccccaa cttcagtgtc aactggacgg taggcgactc cgctattgag     1860

gtcatcaacg ccacgactgg gaaggatgag ctgggccgcg cgtcccgcct gtgtaagcac     1920

gcgttgtact gtcgctggat gcgtgtgcac ggcaaggttc cctcccactt actacgctcc     1980

aagattacca agcccaacgt gtaccatgag tccaagctgg cggcaaagga gtaccaggcc     2040

gccaaggcgc gtctgttcac agccttcatc aaggcggggc tgggggcctg ggtggagaag     2100

cccaccgagc aggaccagtt ctcactcacg ccctga                               2136


<210> 56
<211> 3711
<212> DNA
<213> Homo sapiens

<400> 56
atggaacaaa aacttatttc tgaagaagat ctgaatccgc ggcaggggta ttccctcagc       60

ggatactaca cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct      120

gggccaggat cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag      180

ctcccagaag caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga      240

ctccggccaa ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc      300

aggggtgtcc ccaggggcgt gcatctcaga agtcaggggc tccagagagg gttccagcat      360

ccttcaccac gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc      420

caggaactga gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt      480

ggggaaggga aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa      540

gaaatcaatc gagttttata ctccctggca aagaagggca agctacagaa agaggcagga      600

acaccccctt tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg      660

gtaagaccag acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa      720

gacagaaact ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct      780

caggcttgga accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca      840

aactcagacc caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct      900

cttgagtttt tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg      960

tctgactcct ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata     1020

aatgctgtgc taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct     1080

cccatatggc atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac     1140

agtgttcctg aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc     1200

acctgtaata tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag     1260

aatgggcagg aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca     1320

agactgaaac cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa     1380

aatggccagt gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca     1440

ggtgagtttc gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt     1500

tcaccctaca agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa     1560

tatgcccagt tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc     1620

catgaacctc gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa     1680

gctggaagca agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta     1740

gaggaagcca aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag     1800

aaagaatcag agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt     1860

tctgggaaga gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc     1920

gaattccgtc tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt     1980

gcagtgggag cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag     2040

atggccgcag aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct     2100

gataaccagc ctgaaggtat gatctcagag tcacttgata acttggaatc catgatgccc     2160

aacaaggtca ggaagattgg cgagctcgtg agatacctga acaccaaccc tgtgggtggc     2220

cttttggagt acgcccgctc ccatggcttt gctgctgaat tcaagttggt cgaccagtcc     2280

ggacctcctc acgagcccaa gttcgtttac caagcaaaag ttgggggtcg ctggttccca     2340

gccgtctgcg cacacagcaa gaagcaaggc aagcaggaag cagcagatgc ggctctccgt     2400

gtcttgattg gggagaacga gaaggcagaa cgcatgggtt tcacagaggt aaccccagtg     2460

acaggggcca gtctcagaag aactatgctc ctcctctcaa ggtccccaga agcacagcca     2520

aagacactcc ctctcactgg cagcaccttc catgaccaga tagccatgct gagccaccgg     2580

tgcttcaaca ctctgactaa cagcttccag ccctccttgc tcggccgcaa gattctggcc     2640

gccatcatta tgaaaaaaga ctctgaggac atgggtgtcg tcgtcagctt gggaacaggg     2700

aatcgctgtg tgaaaggaga ttctctcagc ctaaaaggag aaactgtcaa tgactgccat     2760

gcagaaataa tctcccggag aggcttcatc aggtttctct acagtgagtt aatgaaatac     2820

aactcccaga ctgcgaagga tagtatattt gaacctgcta agggaggaga aaagctccaa     2880

ataaaaaaga ctgtgtcatt ccatctgtat atcagcactg ctccgtgtgg agatggcgcc     2940

ctctttgaca agtcctgcag cgaccgtgct atggaaagca cagaatcccg ccactaccct     3000

gtcttcgaga atcccaaaca aggaaagctc cgcaccaagg tggagaacgg agaaggcaca     3060

atccctgtgg aatccagtga cattgtgcct acgtgggatg gcattcggct cggggagaga     3120

ctccgtacca tgtcctgtag tgacaaaatc ctacgctgga acgtgctggg cctgcaaggg     3180

gcactgttga cccacttcct gcagcccatt tatctcaaat ctgtcacatt gggttacctt     3240

ttcagccaag ggcatctgac ccgtgctatt tgctgtcgtg tgacaagaga tgggagtgca     3300

tttgaggatg gactacgaca tccctttatt gtcaaccacc ccaaggttgg cagagtcagc     3360

atatatgatt ccaaaaggca atccgggaag actaaggaga caagcgtcaa ctggtgtctg     3420

gctgatggct atgacctgga gatcctggac ggtaccagag gcactgtgga tgggccacgg     3480

aatgaattgt cccgggtctc caaaaagaac atttttcttc tatttaagaa gctctgctcc     3540

ttccgttacc gcagggatct actgagactc tcctatggtg aggccaagaa agctgcccgt     3600

gactacgaga cggccaagaa ctacttcaaa aaaggcctga aggatatggg ctatgggaac     3660

tggattagca aaccccagga ggaaaagaac ttttatctct gcccagtata g              3711


<210> 57
<211> 6598
<212> DNA
<213> Homo sapiens

<400> 57
ctcacactct gcgcctcctc tcccgggact ttaacacccc gctctcctcc accgaccagg       60

tgaccttttg ctctgagcca gatcagagaa gaattcggtg tccgtgcggg acgatgcctg      120

agcaggagag acagatcaca gccagagaag gggccagtcg gaaaatctta tctaagcttt      180

ctttgcctac ccgtgcctgg gaaccagcaa tgaagaagag ttttgctttt gacaatgttg      240

gctatgaagg tggtctggat ggcctgggcc cttcttctca ggtggccacc agcacagtca      300

ggatcttggg catgacttgc cagtcatgtg tgaagtccat tgaggacagg atttccaatt      360

tgaaaggcat catcagcatg aaggtttccc tggaacaagg cagtgccact gtgaaatatg      420

tgccatcggt tgtgtgcctg caacaggttt gccatcaaat tggggacatg ggcttcgagg      480

ccagcattgc agaaggaaag gcagcctcct ggccctcaag gtccttgcct gcccaggagg      540

ctgtggtcaa gctccgggtg gagggcatga cctgccagtc ctgtgtcagc tccattgaag      600

gcaaggtccg gaaactgcaa ggagtagtga gagtcaaagt ctcactcagc aaccaagagg      660

ccgtcatcac ttatcagcct tatctcattc agcccgaaga cctcagggac catgtaaatg      720

acatgggatt tgaagctgcc atcaagagca aagtggctcc cttaagcctg ggaccaattg      780

atattgagcg gttacaaagc actaacccaa agagaccttt atcttctgct aaccagaatt      840

ttaataattc tgagaccttg gggcaccaag gaagccatgt ggtcaccctc caactgagaa      900

tagatggaat gcattgtaag tcttgcgtct tgaatattga agaaaatatt ggccagctcc      960

taggggttca aagtattcaa gtgtccttgg agaacaaaac tgcccaagta aagtatgacc     1020

cttcttgtac cagcccagtg gctctgcaga gggctatcga ggcacttcca cctgggaatt     1080

ttaaagtttc tcttcctgat ggagccgaag ggagtgggac agatcacagg tcttccagtt     1140

ctcattcccc tggctcccca ccgagaaacc aggtccaggg cacatgcagt accactctga     1200

ttgccattgc cggcatgacc tgtgcatcct gtgtccattc cattgaaggc atgatctccc     1260

aactggaagg ggtgcagcaa atatcggtgt ctttggccga agggactgca acagttcttt     1320

ataatccctc tgtaattagc ccagaagaac tcagagctgc tatagaagac atgggatttg     1380

aggcttcagt cgtttctgaa agctgttcta ctaaccctct tggaaaccac agtgctggga     1440

attccatggt gcaaactaca gatggtacac ctacatctgt gcaggaagtg gctccccaca     1500

ctgggaggct ccctgcaaac catgccccgg acatcttggc aaagtcccca caatcaacca     1560

gagcagtggc accgcagaag tgcttcttac agatcaaagg catgacctgt gcatcctgtg     1620

tgtctaacat agaaaggaat ctgcagaaag aagctggtgt tctctccgtg ttggttgcct     1680

tgatggcagg aaaggcagag atcaagtatg acccagaggt catccagccc ctcgagatag     1740

ctcagttcat ccaggacctg ggttttgagg cagcagtcat ggaggactac gcaggctccg     1800

atggcaacat tgagctgaca atcacaggga tgacctgcgc gtcctgtgtc cacaacatag     1860

agtccaaact cacgaggaca aatggcatca cttatgcctc cgttgccctt gccaccagca     1920

aagcccttgt taagtttgac ccggaaatta tcggtccacg ggatattatc aaaattattg     1980

aggaaattgg ctttcatgct tccctggccc agagaaaccc caacgctcat cacttggacc     2040

acaagatgga aataaagcag tggaagaagt ctttcctgtg cagcctggtg tttggcatcc     2100

ctgtcatggc cttaatgatc tatatgctga tacccagcaa cgagccccac cagtccatgg     2160

tcctggacca caacatcatt ccaggactgt ccattctaaa tctcatcttc tttatcttgt     2220

gtacctttgt ccagctcctc ggtgggtggt acttctacgt tcaggcctac aaatctctga     2280

gacacaggtc agccaacatg gacgtgctca tcgtcctggc cacaagcatt gcttatgttt     2340

attctctggt catcctggtg gttgctgtgg ctgagaaggc ggagaggagc cctgtgacat     2400

tcttcgacac gccccccatg ctctttgtgt tcattgccct gggccggtgg ctggaacact     2460

tggcaaagag caaaacctca gaagccctgg ctaaactcat gtctctccaa gccacagaag     2520

ccaccgttgt gacccttggt gaggacaatt taatcatcag ggaggagcaa gtccccatgg     2580

agctggtgca gcggggcgat atcgtcaagg tggtccctgg gggaaagttt ccagtggatg     2640

ggaaagtcct ggaaggcaat accatggctg atgagtccct catcacagga gaagccatgc     2700

cagtcactaa gaaacccgga agcactgtaa ttgcggggtc tataaatgca catggctctg     2760

tgctcattaa agctacccac gtgggcaatg acaccacttt ggctcagatt gtgaaactgg     2820

tggaagaggc tcagatgtca aaggcaccca ttcagcagct ggctgaccgg tttagtggat     2880

attttgtccc atttatcatc atcatgtcaa ctttgacgtt ggtggtatgg attgtaatcg     2940

gttttatcga ttttggtgtt gttcagagat actttcctaa ccccaacaag cacatctccc     3000

agacagaggt gatcatccgg tttgctttcc agacgtccat cacggtgctg tgcattgcct     3060

gcccctgctc cctggggctg gccacgccca cggctgtcat ggtgggcacc ggggtggccg     3120

cgcagaacgg catcctcatc aagggaggca agcccctgga gatggcgcac aagataaaga     3180

ctgtgatgtt tgacaagact ggcaccatta cccatggcgt ccccagggtc atgcgggtgc     3240

tcctgctggg ggatgtggcc acactgcccc tcaggaaggt tctggctgtg gtggggactg     3300

cggaggccag cagtgaacac cccttgggcg tggcagtcac caaatactgt aaagaggaac     3360

ttggaacaga gaccttggga tactgcacgg acttccaggc agtgccaggc tgtggaattg     3420

ggtgcaaagt cagcaacgtg gaaggcatcc tggcccacag tgagcgccct ttgagtgcac     3480

cggccagtca cctgaatgag gctggcagcc ttcccgcaga aaaagatgca gtcccccaga     3540

ccttctctgt gctgattgga aaccgtgagt ggctgaggcg caacggttta accatttcta     3600

gcgatgtcag tgacgctatg acagaccacg agatgaaagg acagacagcc atcctggtgg     3660

ctattgacgg tgtgctctgt gggatgatcg caatcgcaga cgctgtcaag caggaggctg     3720

ccctggctgt gcacacgctg cagagcatgg gtgtggacgt ggttctgatc acgggggaca     3780

accggaagac agccagagct attgccaccc aggttggcat caacaaagtc tttgcagagg     3840

tgctgccttc gcacaaggtg gccaaggtcc aggagctcca gaataaaggg aagaaagtcg     3900

ccatggtggg ggatggggtc aatgactccc cggccttggc ccaggcagac atgggtgtgg     3960

ccattggcac cggcacggat gtggccatcg aggcagccga cgtcgtcctt atcagaaatg     4020

atttgctgga tgtggtggct agcattcacc tttccaagag gactgtccga aggatacgca     4080

tcaacctggt cctggcactg atttataacc tggttgggat acccattgca gcaggtgtct     4140

tcatgcccat cggcattgtg ctgcagccct ggatgggctc agcggccatg gcagcctcct     4200

ctgtgtctgt ggtgctctca tccctgcagc tcaagtgcta taagaagcct gacctggaga     4260

ggtatgaggc acaggcgcat ggccacatga agcccctgac ggcatcccag gtcagtgtgc     4320

acataggcat ggatgacagg tggcgggact cccccagggc cacaccatgg gaccaggtca     4380

gctatgtcag ccaggtgtcg ctgtcctccc tgacgtccga caagccatct cggcacagcg     4440

ctgcagcaga cgatgatggg gacaagtggt ctctgctcct gaatggcagg gatgaggagc     4500

agtacatctg atgacttcag gcaggcgggc cggggcaggg acttgcctcc actcaccaca     4560

agctgagcag gacagccagc agcaggatgg gctgagctag cctccagctt tggggacttc     4620

cgctccctgg atatgtccag tcatcctgcc ctgcagcacg cggccttgtc tgggtgcagc     4680

tgggcttggc ctggagagga cggccctgcc tgcctcttgg cctcacggga ccgtcagcat     4740

gggctttgtc ttggactcta gtccttggct ggactgtaga aggtgagagg cgagtcaccc     4800

tcctcacaga cctctgcttg gagtatttag gatgactgct gtgaaatgga gaacagtttc     4860

atcaggacca aaaaacctca ctgggccttt ccagagaact gcagacctca ctgtcagggt     4920

ctttctgatg acgcctgtct gtgtgcatca tgtttctgag accacagttt acctcaggtg     4980

tgcctgttgc tttcttcctg catagtctgt tcctttcttc gtacatagtc tgttcctttt     5040

ctctcctgtg tgcttgtcag tggggacccc tcgcaaccct gcctgtcacc tgggagggtg     5100

ggaccaatgt ccttgtggtc tttgctgctg ctctcaggcg cttctccaat gctctggagt     5160

gtgcatttca gcttgaacct gcttcctggc tcacacatcc ccagccaggg agcttgccac     5220

actcttcttc aagttgagga gagttctttt ttgcttaaag cccccttctc catggagtgt     5280

tggcttctca atagagtgtt gttgctgacc agctggagtg agggcctcag agcctgacct     5340

gagagtccgt actcggcttc ctgtggggtg taggttctcg cgattcagga cgtccttcca     5400

tatccctgcc cagcctgtgg tgcttgaaac gtttgcccca tgggaaacgt atgtgtgcag     5460

gagcctccct gcacggccca aggggcttcg ttttcagtct tctgactgtc acctcgtggg     5520

gttcagtaga gaattcatgt gactagcgcc tggccttgtg tggcttggag gaaatggtac     5580

tgcccaaata ggaggaaaac acagcctccc tgagcctgca ttctgcacgc tgcccagggg     5640

cttcagaaaa ggagtggcca cagcaccccg aagggagcat ctgtttacct ggcagtggct     5700

ctcagagcag cagaacgggt tcagttttag actctgaagt tggttgtgat tgacagaacc     5760

ctttgggagc aaactagtag agttggatta aattctgggt gaaacccttt tctcccacac     5820

aaaatagttt tagtgatttt tttcattgtc cattacttgc caggggcagt tttagcagca     5880

cttttgatag attacgtcta atcctcccaa ccaaccagca gggtagctat tactgtccac     5940

attttacagg caaggaaaca ggctccaaga ggctgaggac tttgcccagg atgacatagc     6000

caatggacaa gcagtgtctg tcagctgtga aggcttcact cttattgtcc ttctaccttg     6060

aatagaagtt ttcctgataa gaataaacga ggaaaaggtc cttgcctcct ggaagaacaa     6120

atctaccagg tgatctattc attgtttcaa ctcagaatgc acttgattca ggaggtcatc     6180

tgaccttcac cttggatggt tagtttcact ttttacatat agtttttgca gggttttatt     6240

ttataaaatc caagcgcgct gttgattgtg ttttccttgt tttcagcccc cccactccag     6300

cccgcagcac atttccgctg tccgtcagta attgtgtcct ctctttatgc ttgcttgggg     6360

aatgttgttt tctgactagg ctgatcatta tctaaagaat ctaattctgt tgatttttaa     6420

aacttttagg accataaacg ttgtgttcat atatggacat ggaaatattt atataatttt     6480

atagaaaata accttttaga tggtcaaagt gtaaggagtt tttttgtcag ataatcattt     6540

ctacttcaaa aacatttcat gcaatattag aataaagttc ctgtcattcc tctaaaaa       6598


<210> 58
<211> 3320
<212> DNA
<213> Homo sapiens

<400> 58
ctcacactct gcgcctcctc tcccgggact ttaacacccc gctctcctcc accgaccagg       60

tgaccttttg ctctgagcca gatcagagaa gaattcggtg tccgtgcggg acgatgcctg      120

agcaggagag acagatcaca gccagagaag gggccagtcg gaaaatctta tctaagcttt      180

ctttgcctac ccgtgcctgg gaaccagcaa tgaagaagag ttttgctttt gacaatgttg      240

gctatgaagg tggtctggat ggcctgggcc cttcttctca ggtggccacc agcacagtca      300

ggatcttggg catgacttgc cagtcatgtg tgaagtccat tgaggacagg atttccaatt      360

tgaaaggcat catcagcatg aaggtttccc tggaacaagg cagtgccact gtgaaatatg      420

tgccatcggt tgtgtgcctg caacaggttt gccatcaaat tggggacatg ggcttcgagg      480

ccagcattgc agaaggaaag gcagcctcct ggccctcaag gtccttgcct gcccaggagg      540

ctgtggtcaa gctccgggtg gagggcatga cctgccagtc ctgtgtcagc tccattgaag      600

gcaaggtccg gaaactgcaa ggagtagtga gagtcaaagt ctcactcagc aaccaagagg      660

ccgtcatcac ttatcagcct tatctcattc agcccgaaga cctcagggac catgtaaatg      720

acatgggatt tgaagctgcc atcaagagca aagtggctcc cttaagcctg ggaccaattg      780

atattgagcg gttacaaagc actaacccaa agagaccttt atcttctgct aaccagaatt      840

ttaataattc tgagaccttg gggcaccaag gaagccatgt ggtcaccctc caactgagaa      900

tagatggaat gcattgtaag tcttgcgtct tgaatattga agaaaatatt ggccagctcc      960

taggggttca aagtattcaa gtgtccttgg agaacaaaac tgcccaagta aagtatgacc     1020

cttcttgtac cagcccagtg gctctgcaga gggctatcga ggcacttcca cctgggaatt     1080

ttaaagtttc tcttcctgat ggagccgaag ggagtgggac agatcacagg tcttccagtt     1140

ctcattcccc tggctcccca ccgagaaacc aggtccaggg cacatgcagt accactctga     1200

ttgccattgc cggcatgacc tgtgcatcct gtgtccattc cattgaaggc atgatctccc     1260

aactggaagg ggtgcagcaa atatcggtgt ctttggccga agggactgca acagttcttt     1320

ataatccctc tgtaattagc ccagaagaac tcagagctgc tatagaagac atgggatttg     1380

aggcttcagt cgtttctgaa agctgttcta ctaaccctct tggaaaccac agtgctggga     1440

attccatggt gcaaactaca gatggtacac ctacatctgt gcaggaagtg gctccccaca     1500

ctgggaggct ccctgcaaac catgccccgg acatcttggc aaagtcccca caatcaacca     1560

gagcagtggc accgcagaag tgcttcttac agatcaaagg catgacctgt gcatcctgtg     1620

tgtctaacat agaaaggaat ctgcagaaag aagctggtgt tctctccgtg ttggttgcct     1680

tgatggcagg aaaggcagag atcaagtatg acccagaggt catccagccc ctcgagatag     1740

ctcagttcat ccaggacctg ggttttgagg cagcagtcat ggaggactac gcaggctccg     1800

atggcaacat tgagctgaca atcacaggga tgacctgcgc gtcctgtgtc cacaacatag     1860

agtccaaact cacgaggaca aatggcatca cttatgcctc cgttgccctt gccaccagca     1920

aagcccttgt taagtttgac ccggaaatta tcggtccacg ggatattatc aaaattattg     1980

aggaaattgg ctttcatgct tccctggccc agagaaaccc caacgctcat cacttggacc     2040

acaagatgga aataaagcag tggaagaagt ctttcctgtg cagcctggtg tttggcatcc     2100

ctgtcatggc cttaatgatc tatatgctga tacccagcaa cgagccccac cagtccatgg     2160

tcctggacca caacatcatt ccaggactgt ccattctaaa tctcatcttc tttatcttgt     2220

gtacctttgt ccagctcctc ggtgggtggt acttctacgt tcaggcctac aaatctctga     2280

gacacaggtc agccaacatg gacgtgctca tcgtcctggc cacaagcatt gcttatgttt     2340

attctctggt catcctggtg gttgctgtgg ctgagaaggc ggagaggagc cctgtgacat     2400

tcttcgacac gccccccatg ctctttgtgt tcattgccct gggccggtgg ctggaacact     2460

tggcaaagag caaaacctca gaagccctgg ctaaactcat gtctctccaa gccacagaag     2520

ccaccgttgt gacccttggt gaggacaatt taatcatcag ggaggagcaa gtccccatgg     2580

agctggtgca gcggggcgat atcgtcaagg tggtccctgg gggaaagttt ccagtggatg     2640

ggaaagtcct ggaaggcaat accatggctg atgagtccct catcacagga gaagccatgc     2700

cagtcactaa gaaacccgga agcactgtaa ttgcggggtc tataaatgca catggctctg     2760

tgctcattaa agctacccac gtgggcaatg acaccacttt ggctcagatt gtgaaactgg     2820

tggaagaggc tcagatgtca aaggcaccca ttcagcagct ggctgaccgg tttagtggat     2880

attttgtccc atttatcatc atcatgtcaa ctttgacgtt ggtggtatgg attgtaatcg     2940

gttttatcga ttttggtgtt gttcagagat actttcctaa ccccaacaag cacatctccc     3000

agacagaggt gatcatccgg tttgctttcc agacgtccat cacggtgctg tgcattgcct     3060

gcccctgctc cctggggctg gccacgccca cggctgtcat ggtgggcacc ggggtggccg     3120

cgcagaacgg catcctcatc aagggaggca agcccctgga gatggcgcac aagataaaga     3180

ctgtgatgtt tgacaagact ggcaccatta cccatggcgt ccccagggtc atgcgggtgc     3240

tcctgctggg ggatgtggcc acactgcccc tcaggaaggt tctggctgtg gtggggactg     3300

cggaggccag cagtgaacaa                                                 3320


<210> 59
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
tgacaagact ggcacc                                                       16


<210> 60
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
gttgctgact ttgcacc                                                      17


<210> 61
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 61
ucuuuacagu auuuggugac ugccacgccc aagggtcguu cacugcu                     47


<210> 62
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 62
ucuuuacagu auuuggugac ugccacgccc aagggtcguu cacugcu                     47


<210> 63
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 63
ucuuuacagu auuuggugac ugccacgccc aagggtcguu cacugcu                     47


<210> 64
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 64
ucuuuacagu auuuggugac ugccacgccc aagggtcguu cacugcu                     47


<210> 65
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 65
ucuuuacagu auuuggugac ugccacgccc aagggtcguu cacugcu                     47


<210> 66
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 66
ucuuuacagu auuuggugac ugccacgccc aagggtcguu cacugcu                     47


<210> 67
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 67
ucuuuacagu auuuggugac ugccacgccc aagggtcguu cacugcu                     47


<210> 68
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 68
gucucuguuc caaguuccuc uuuacaguau uuggugacug ccacgcccaa gggtcguuca       60

cugcu                                                                   65


<210> 69
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 69
gucucuguuc caaguuccuc uuuacaguau uuggugacug ccacgcccaa gggtcguuca       60

cugcu                                                                   65


<210> 70
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 70
gucucuguuc caaguuccuc uuuacaguau uuggugacug ccacgcccaa gggtcguuca       60

cugcu                                                                   65


<210> 71
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 71
gucucuguuc caaguuccuc uuuacaguau uuggugacug ccacgcccaa gggtcguuca       60

cugcu                                                                   65


<210> 72
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 72
gucucuguuc caaguuccuc uuuacaguau uuggugacug ccacgcccaa gggtcguuca       60

cugcu                                                                   65


<210> 73
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 73
gucucuguuc caaguuccuc uuuacaguau uuggugacug ccacgcccaa gggtcguuca       60

cugcu                                                                   65


<210> 74
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 74
gucucuguuc caaguuccuc uuuacaguau uuggugacug ccacgcccaa gggtcguuca       60

cugcu                                                                   65


<210> 75
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 75
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacccaagg       60

gtcguucacu gcu                                                          73


<210> 76
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 76
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacccaagg       60

gtcguucacu gcu                                                          73


<210> 77
<211> 85
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 77
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccaccaguau uuggugacug       60

ccacgcccaa gggtcguuca cugcu                                             85


<210> 78
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 78
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccaguau       60

uuggugacug ccacgcccaa gggtcguuca cugcu                                  95


<210> 79
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 79
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccaguau       60

uuggugacug ccacgcccaa gggtcguuca cugcu                                  95


<210> 80
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 80
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccaguau       60

uuggugacug ccacgcccaa gggtcguuca cugcu                                  95


<210> 81
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 81
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccaguau       60

uuggugacug ccacgcccaa gggtcguuca cugcu                                  95


<210> 82
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 82
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccaguau       60

uuggugacug ccacgcccaa gggtcguuca cugcu                                  95


<210> 83
<211> 1465
<212> PRT
<213> Homo sapiens

<400> 83
Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu 
    610                 615                 620                 


Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His 
625                 630                 635                 640 


Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys 
                645                 650                 655     


Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu 
            660                 665                 670         


Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile 
        675                 680                 685             


Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr 
    690                 695                 700                 


Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys 
705                 710                 715                 720 


Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala 
                725                 730                 735     


Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val 
            740                 745                 750         


Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro 
        755                 760                 765             


Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala 
    770                 775                 780                 


Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala 
785                 790                 795                 800 


Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg 
                805                 810                 815     


Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys 
            820                 825                 830         


Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly 
        835                 840                 845             


Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val 
    850                 855                 860                 


Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His 
865                 870                 875                 880 


Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu 
                885                 890                 895     


Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro 
            900                 905                 910         


Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile 
        915                 920                 925             


Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe 
    930                 935                 940                 


Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His 
945                 950                 955                 960 


Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile 
                965                 970                 975     


Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro 
            980                 985                 990         


Thr Ala Val Met Val Gly Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu 
        995                 1000                 1005             


Ile Lys  Gly Gly Lys Pro Leu  Glu Met Ala His Lys  Ile Lys Thr 
    1010                 1015                 1020             


Val Met  Phe Asp Lys Thr Gly  Thr Ile Thr His Gly  Val Pro Arg 
    1025                 1030                 1035             


Val Met  Arg Val Leu Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu 
    1040                 1045                 1050             


Arg Lys  Val Leu Ala Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu 
    1055                 1060                 1065             


His Pro  Leu Gly Val Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu 
    1070                 1075                 1080             


Gly Thr  Glu Thr Leu Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro 
    1085                 1090                 1095             


Gly Cys  Gly Ile Gly Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu 
    1100                 1105                 1110             


Ala His  Ser Glu Arg Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn 
    1115                 1120                 1125             


Glu Ala  Gly Ser Leu Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr 
    1130                 1135                 1140             


Phe Ser  Val Leu Ile Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly 
    1145                 1150                 1155             


Leu Thr  Ile Ser Ser Asp Val  Ser Asp Ala Met Thr  Asp His Glu 
    1160                 1165                 1170             


Met Lys  Gly Gln Thr Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu 
    1175                 1180                 1185             


Cys Gly  Met Ile Ala Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala 
    1190                 1195                 1200             


Leu Ala  Val His Thr Leu Gln  Ser Met Gly Val Asp  Val Val Leu 
    1205                 1210                 1215             


Ile Thr  Gly Asp Asn Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln 
    1220                 1225                 1230             


Val Gly  Ile Asn Lys Val Phe  Ala Glu Val Leu Pro  Ser His Lys 
    1235                 1240                 1245             


Val Ala  Lys Val Gln Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala 
    1250                 1255                 1260             


Met Val  Gly Asp Gly Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala 
    1265                 1270                 1275             


Asp Met  Gly Val Ala Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu 
    1280                 1285                 1290             


Ala Ala  Asp Val Val Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val 
    1295                 1300                 1305             


Ala Ser  Ile His Leu Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile 
    1310                 1315                 1320             


Asn Leu  Val Leu Ala Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile 
    1325                 1330                 1335             


Ala Ala  Gly Val Phe Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp 
    1340                 1345                 1350             


Met Gly  Ser Ala Ala Met Ala  Ala Ser Ser Val Ser  Val Val Leu 
    1355                 1360                 1365             


Ser Ser  Leu Gln Leu Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg 
    1370                 1375                 1380             


Tyr Glu  Ala Gln Ala His Gly  His Met Lys Pro Leu  Thr Ala Ser 
    1385                 1390                 1395             


Gln Val  Ser Val His Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser 
    1400                 1405                 1410             


Pro Arg  Ala Thr Pro Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val 
    1415                 1420                 1425             


Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala 
    1430                 1435                 1440             


Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly 
    1445                 1450                 1455             


Arg Asp  Glu Glu Gln Tyr Ile  
    1460                 1465 


<210> 84
<211> 1465
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu 
    610                 615                 620                 


Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His 
625                 630                 635                 640 


Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys 
                645                 650                 655     


Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu 
            660                 665                 670         


Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile 
        675                 680                 685             


Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr 
    690                 695                 700                 


Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys 
705                 710                 715                 720 


Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala 
                725                 730                 735     


Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val 
            740                 745                 750         


Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro 
        755                 760                 765             


Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala 
    770                 775                 780                 


Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala 
785                 790                 795                 800 


Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg 
                805                 810                 815     


Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys 
            820                 825                 830         


Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly 
        835                 840                 845             


Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val 
    850                 855                 860                 


Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His 
865                 870                 875                 880 


Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu 
                885                 890                 895     


Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro 
            900                 905                 910         


Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile 
        915                 920                 925             


Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe 
    930                 935                 940                 


Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His 
945                 950                 955                 960 


Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile 
                965                 970                 975     


Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro 
            980                 985                 990         


Thr Ala Val Met Val Gly Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu 
        995                 1000                 1005             


Ile Lys  Gly Gly Lys Pro Leu  Glu Met Ala His Lys  Ile Lys Thr 
    1010                 1015                 1020             


Val Met  Phe Asp Lys Thr Gly  Thr Ile Thr His Gly  Val Pro Arg 
    1025                 1030                 1035             


Val Met  Arg Val Leu Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu 
    1040                 1045                 1050             


Arg Lys  Val Leu Ala Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu 
    1055                 1060                 1065             


Gln Pro  Leu Gly Val Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu 
    1070                 1075                 1080             


Gly Thr  Glu Thr Leu Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro 
    1085                 1090                 1095             


Gly Cys  Gly Ile Gly Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu 
    1100                 1105                 1110             


Ala His  Ser Glu Arg Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn 
    1115                 1120                 1125             


Glu Ala  Gly Ser Leu Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr 
    1130                 1135                 1140             


Phe Ser  Val Leu Ile Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly 
    1145                 1150                 1155             


Leu Thr  Ile Ser Ser Asp Val  Ser Asp Ala Met Thr  Asp His Glu 
    1160                 1165                 1170             


Met Lys  Gly Gln Thr Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu 
    1175                 1180                 1185             


Cys Gly  Met Ile Ala Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala 
    1190                 1195                 1200             


Leu Ala  Val His Thr Leu Gln  Ser Met Gly Val Asp  Val Val Leu 
    1205                 1210                 1215             


Ile Thr  Gly Asp Asn Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln 
    1220                 1225                 1230             


Val Gly  Ile Asn Lys Val Phe  Ala Glu Val Leu Pro  Ser His Lys 
    1235                 1240                 1245             


Val Ala  Lys Val Gln Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala 
    1250                 1255                 1260             


Met Val  Gly Asp Gly Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala 
    1265                 1270                 1275             


Asp Met  Gly Val Ala Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu 
    1280                 1285                 1290             


Ala Ala  Asp Val Val Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val 
    1295                 1300                 1305             


Ala Ser  Ile His Leu Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile 
    1310                 1315                 1320             


Asn Leu  Val Leu Ala Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile 
    1325                 1330                 1335             


Ala Ala  Gly Val Phe Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp 
    1340                 1345                 1350             


Met Gly  Ser Ala Ala Met Ala  Ala Ser Ser Val Ser  Val Val Leu 
    1355                 1360                 1365             


Ser Ser  Leu Gln Leu Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg 
    1370                 1375                 1380             


Tyr Glu  Ala Gln Ala His Gly  His Met Lys Pro Leu  Thr Ala Ser 
    1385                 1390                 1395             


Gln Val  Ser Val His Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser 
    1400                 1405                 1410             


Pro Arg  Ala Thr Pro Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val 
    1415                 1420                 1425             


Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala 
    1430                 1435                 1440             


Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly 
    1445                 1450                 1455             


Arg Asp  Glu Glu Gln Tyr Ile  
    1460                 1465 


<210> 85
<211> 1465
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu 
    610                 615                 620                 


Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His 
625                 630                 635                 640 


Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys 
                645                 650                 655     


Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu 
            660                 665                 670         


Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile 
        675                 680                 685             


Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr 
    690                 695                 700                 


Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys 
705                 710                 715                 720 


Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala 
                725                 730                 735     


Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val 
            740                 745                 750         


Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro 
        755                 760                 765             


Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala 
    770                 775                 780                 


Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala 
785                 790                 795                 800 


Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg 
                805                 810                 815     


Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys 
            820                 825                 830         


Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly 
        835                 840                 845             


Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val 
    850                 855                 860                 


Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His 
865                 870                 875                 880 


Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu 
                885                 890                 895     


Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro 
            900                 905                 910         


Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile 
        915                 920                 925             


Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe 
    930                 935                 940                 


Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His 
945                 950                 955                 960 


Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile 
                965                 970                 975     


Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro 
            980                 985                 990         


Thr Ala Val Met Val Gly Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu 
        995                 1000                 1005             


Ile Lys  Gly Gly Lys Pro Leu  Glu Met Ala His Lys  Ile Lys Thr 
    1010                 1015                 1020             


Val Met  Phe Asp Lys Thr Gly  Thr Ile Thr His Gly  Val Pro Arg 
    1025                 1030                 1035             


Val Met  Arg Val Leu Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu 
    1040                 1045                 1050             


Arg Lys  Val Leu Ala Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu 
    1055                 1060                 1065             


Arg Pro  Leu Gly Val Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu 
    1070                 1075                 1080             


Gly Thr  Glu Thr Leu Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro 
    1085                 1090                 1095             


Gly Cys  Gly Ile Gly Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu 
    1100                 1105                 1110             


Ala His  Ser Glu Arg Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn 
    1115                 1120                 1125             


Glu Ala  Gly Ser Leu Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr 
    1130                 1135                 1140             


Phe Ser  Val Leu Ile Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly 
    1145                 1150                 1155             


Leu Thr  Ile Ser Ser Asp Val  Ser Asp Ala Met Thr  Asp His Glu 
    1160                 1165                 1170             


Met Lys  Gly Gln Thr Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu 
    1175                 1180                 1185             


Cys Gly  Met Ile Ala Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala 
    1190                 1195                 1200             


Leu Ala  Val His Thr Leu Gln  Ser Met Gly Val Asp  Val Val Leu 
    1205                 1210                 1215             


Ile Thr  Gly Asp Asn Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln 
    1220                 1225                 1230             


Val Gly  Ile Asn Lys Val Phe  Ala Glu Val Leu Pro  Ser His Lys 
    1235                 1240                 1245             


Val Ala  Lys Val Gln Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala 
    1250                 1255                 1260             


Met Val  Gly Asp Gly Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala 
    1265                 1270                 1275             


Asp Met  Gly Val Ala Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu 
    1280                 1285                 1290             


Ala Ala  Asp Val Val Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val 
    1295                 1300                 1305             


Ala Ser  Ile His Leu Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile 
    1310                 1315                 1320             


Asn Leu  Val Leu Ala Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile 
    1325                 1330                 1335             


Ala Ala  Gly Val Phe Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp 
    1340                 1345                 1350             


Met Gly  Ser Ala Ala Met Ala  Ala Ser Ser Val Ser  Val Val Leu 
    1355                 1360                 1365             


Ser Ser  Leu Gln Leu Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg 
    1370                 1375                 1380             


Tyr Glu  Ala Gln Ala His Gly  His Met Lys Pro Leu  Thr Ala Ser 
    1385                 1390                 1395             


Gln Val  Ser Val His Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser 
    1400                 1405                 1410             


Pro Arg  Ala Thr Pro Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val 
    1415                 1420                 1425             


Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala 
    1430                 1435                 1440             


Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly 
    1445                 1450                 1455             


Arg Asp  Glu Glu Gln Tyr Ile  
    1460                 1465 


