                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior
 
<120>  ENGINEERED BMP2 SURROGATE PROTEINS

<130>  STAN-1844WO

<150>  63/196,540
<151>  2021-06-03

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser 
1               5                   10                  15      


Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr 
            20                  25                  30          


Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala 
        35                  40                  45              


Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu 
    50                  55                  60                  


Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr 
65                  70                  75                  80  


Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg 
                85                  90                  95      


Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln 
            100                 105                 110         


Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile 
        115                 120                 125             


Arg 
    


<210>  2
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Gln Asn Gln Glu Arg Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln 
1               5                   10                  15      


Asp Leu Gly Ile Gly Glu Ser Arg Ile Ser His Glu Asn Gly Thr Ile 
            20                  25                  30          


Leu Cys Ser Lys Gly Ser Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys 
        35                  40                  45              


Gly Asp Ile Asn Leu Val Lys Gln Gly Cys Trp Ser His Ile Gly Asp 
    50                  55                  60                  


Pro Gln Glu Cys His Tyr Glu Glu Cys Val Val Thr Thr Thr Pro Pro 
65                  70                  75                  80  


Ser Ile Gln Asn Gly Thr Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu 
                85                  90                  95      


Cys Asn Val Asn Phe Thr Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro 
            100                 105                 110         


Leu Ser Pro Pro His Ser Phe Asn Arg Asp Glu Thr 
        115                 120                 


<210>  3
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys 
        115                 120                 125             


Arg Lys Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg 
    130                 135                 140                 


Cys Cys Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro 
145                 150                 155                 160 


Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys 
                165                 170                 175     


Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu 
            180                 185                 190         


Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
        195                 200                 205     


<210>  4
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Ser Ala Ser Tyr 
            20                  25                  30          


Glu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Gly Pro Ser Tyr Gly Ala Pro Asp Val Ile His Phe Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Asn Ile Ser Ala Ser Tyr Glu Met 
1               5                   


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Leu Val Ala Ala Ile Asp Ser Gly Ala Ser Thr Tyr Tyr 
1               5                   10                  


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ala Ala Gly Pro Ser Tyr Gly Ala Pro Asp Val Ile His Phe Tyr 
1               5                   10                  15      


<210>  8
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Gly Arg Gln 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ala Tyr Gly Ala Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Val Ala Val Asp Pro Glu Val Leu Trp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Thr Ile Ser Gly Arg Gln Ala Met 
1               5                   


<210>  10
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  10

Glu Phe Val Ala Gly Ile Ala Tyr Gly Ala Thr Thr Asn Tyr 
1               5                   10                  


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ala Val Ala Val Asp Pro Glu Val Leu Trp Tyr 
1               5                   10          


<210>  12
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Tyr Phe Ser 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Val Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Phe Asp Ser Ile Ser Gly Glu Leu Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Thr Ile Phe Tyr Phe Ser Ile Met 
1               5                   


<210>  14
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Phe Val Ala Gly Ile Gly Val Gly Ser Asn Thr Tyr Tyr 
1               5                   10                  


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Ala Phe Asp Ser Ile Ser Gly Glu Leu Gln Tyr 
1               5                   10          


<210>  16
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Tyr Arg Gly 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Asp Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Trp His Arg Arg Thr Gly Val Leu Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Ser Ile Phe Tyr Arg Gly Val Met 
1               5                   


<210>  18
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Leu Val Ala Ala Ile Asn Asp Gly Ala Thr Thr Tyr Tyr 
1               5                   10                  


<210>  19
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Val Trp His Arg Arg Thr Gly Val Leu Leu Tyr 
1               5                   10          


<210>  20
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Val Arg Asp 
            20                  25                  30          


Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Gln Gly Ser Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Leu Tyr Trp Arg Gln Asp Trp His Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Thr Ile Ser Val Arg Asp Pro Met 
1               5                   


<210>  22
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Phe Val Ala Gly Ile Gly Gln Gly Ser Thr Thr Asn Tyr 
1               5                   10                  


<210>  23
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Val Leu Tyr Trp Arg Gln Asp Trp His Leu Tyr 
1               5                   10          


<210>  24
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Gly Gly Asp 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asn Ala Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Ala Gly Tyr Phe Pro Tyr Val His Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ser Ile Phe Gly Gly Asp Ala Met 
1               5                   


<210>  26
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Leu Val Ala Gly Ile Asn Ala Gly Thr Ser Thr Tyr Tyr 
1               5                   10                  


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Val Ala Gly Tyr Phe Pro Tyr Val His Thr Tyr 
1               5                   10          


<210>  28
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Asp Gly Pro 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Tyr Gly Thr Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Ile Val Pro Tyr Asn Ser Asp Arg Ser Leu Tyr Leu Trp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Thr Ile Ser Asp Gly Pro Val Met 
1               5                   


<210>  30
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Phe Val Ala Gly Ile Gly Tyr Gly Thr Asn Thr Asn Tyr 
1               5                   10                  


<210>  31
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Val Ile Val Pro Tyr Asn Ser Asp Arg Ser Leu Tyr Leu Trp Tyr 
1               5                   10                  15      


<210>  32
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Ser Tyr Tyr Arg 
            20                  25                  30          


His Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Gly Asp Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Val His Asn Thr Tyr Leu Leu Tyr Asp Pro Tyr Val Trp Asp Tyr 
            100                 105                 110         


Leu Leu Leu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Thr Ile Ser Arg Gln Gln Thr Met 
1               5                   


<210>  34
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Phe Val Ala Ser Ile Ala Gln Gly Gly Asn Thr Tyr Tyr 
1               5                   10                  


<210>  35
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Val Tyr Glu Arg Ser Asp Thr Glu Tyr Tyr Leu Arg Tyr 
1               5                   10                  


<210>  36
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Trp Thr Ala 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Ala Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Thr Pro Asp Arg Thr Gly Ile Ala Lys Trp His Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Thr Ile Phe Trp Thr Ala Ser Met 
1               5                   


<210>  38
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Leu Val Ala Gly Ile Thr Ala Gly Ala Thr Thr Tyr Tyr 
1               5                   10                  


<210>  39
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Ala Arg Thr Pro Asp Arg Thr Gly Ile Ala Lys Trp His Asp Tyr 
1               5                   10                  15      


<210>  40
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ile Pro Leu 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Thr Tyr Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Tyr Val Val Tyr Glu Thr His Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Thr Ile Phe Ile Pro Leu Gly Met 
1               5                   


<210>  42
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Leu Val Ala Gly Ile Thr Tyr Gly Gly Ile Thr Tyr Tyr 
1               5                   10                  


<210>  43
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ala Arg Tyr Val Val Tyr Glu Thr His Asp Tyr 
1               5                   10          


<210>  44
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Pro Arg Ile 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        35                  40                  45              


Ser Ile Asn Asp Gly Ala Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Ala Val Trp Tyr Asp Gly Trp Leu Val Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Thr Ile Ser Pro Arg Ile Met 
1               5               


<210>  46
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Phe Val Ala Ser Ile Asn Asp Gly Ala Ser Thr Asn Tyr 
1               5                   10                  


<210>  47
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Ala Ala Val Trp Tyr Asp Gly Trp Leu Val Tyr 
1               5                   10          


<210>  48
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Arg Ala Val 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Thr Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Trp Tyr Pro Ala Pro Gly Phe Asn His Tyr Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  49
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Asn Ile Phe Arg Ala Val Asn Met 
1               5                   


<210>  50
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Leu Val Ala Ala Ile Thr Thr Gly Ala Asn Thr Tyr Tyr 
1               5                   10                  


<210>  51
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Ala Arg Trp Tyr Pro Ala Pro Gly Phe Asn His Tyr Tyr Asp Tyr 
1               5                   10                  15      


<210>  52
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ala Thr 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Ala Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Val Val Phe Thr Ser Gln Asp Arg Ile Tyr Tyr Tyr Arg Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  53
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ser Ile Ser Ser Ala Thr Val Met 
1               5                   


<210>  54
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Phe Val Ala Ala Ile Thr Ala Gly Gly Thr Thr Asn Tyr 
1               5                   10                  


<210>  55
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  55

Ala Val Val Val Phe Thr Ser Gln Asp Arg Ile Tyr Tyr Tyr Arg Tyr 
1               5                   10                  15      


<210>  56
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Pro Ala Gln 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Asn Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Phe Gln Trp Asp Asp Asn Asp Gly Arg Tyr Tyr Leu Gly Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  57
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Ser Ile Phe Pro Ala Gln Val Met 
1               5                   


<210>  58
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Leu Val Ala Gly Ile Asn Tyr Gly Gly Ser Thr Tyr Tyr 
1               5                   10                  


<210>  59
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Val Phe Gln Trp Asp Asp Asn Asp Gly Arg Tyr Tyr Leu Gly Tyr 
1               5                   10                  15      


<210>  60
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe His Gly Ser 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Ala Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Ala Gln Gln Gln His Gly Thr Asp Arg Ser Trp Phe Ile Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  61
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Thr Ile Phe His Gly Ser Thr Met 
1               5                   


<210>  62
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Leu Val Ala Gly Ile Ala Ser Gly Ser Ser Thr Tyr Tyr 
1               5                   10                  


<210>  63
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  63

Ala Val Ala Gln Gln Gln His Gly Thr Asp Arg Ser Trp Phe Ile Tyr 
1               5                   10                  15      


<210>  64
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Ile Tyr Gly 
            20                  25                  30          


Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Ser Leu Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Ser Ile Ala Lys Ser Asp Tyr Pro Tyr Trp His Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  65
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Thr Ile Ser Ile Tyr Gly Pro Met 
1               5                   


<210>  66
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  66

Glu Leu Val Ala Gly Ile Ser Leu Gly Gly Ser Thr Asn Tyr 
1               5                   10                  


<210>  67
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Ala Ala Ser Ile Ala Lys Ser Asp Tyr Pro Tyr Trp His Leu Tyr 
1               5                   10                  15      


<210>  68
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  68

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Ala Arg Lys 
            20                  25                  30          


Arg Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Asp Tyr Gly Thr Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Ile Asp Tyr Val Pro Ile Asp Tyr Tyr Gln Tyr Ala Ala Gly Trp 
            100                 105                 110         


His Phe Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  69
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Asn Ile Ser Pro Thr Tyr Leu Met 
1               5                   


<210>  70
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  70

Glu Phe Val Ala Gly Ile Ala His Gly Ala Ser Thr Asn Tyr 
1               5                   10                  


<210>  71
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  71

Ala Val Asn Pro Tyr Ala Leu Asp Val Leu Val Tyr 
1               5                   10          


<210>  72
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  72

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Ser Ala Ser Tyr 
            20                  25                  30          


Glu Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asp Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Gly Pro Ser Tyr Gly Ala Pro Asp Val Ile His Phe Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Ile 
145                 150                 155                 160 


Tyr Gly Pro Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     


Leu Val Ala Gly Ile Ser Leu Gly Gly Ser Thr Asn Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Ala Ala Ser Ile Ala Lys Ser Asp Tyr Pro Tyr Trp His Leu 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250         


<210>  73
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Tyr Phe Ser 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Val Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Phe Asp Ser Ile Ser Gly Glu Leu Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Val 
        115                 120                 125             


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Ser Ile Tyr Gly Pro Met 
145                 150                 155                 160 


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Gly 
                165                 170                 175     


Ile Ser Leu Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
    210                 215                 220                 


Ser Ile Ala Lys Ser Asp Tyr Pro Tyr Trp His Leu Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser 
                245             


<210>  74
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  74

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Tyr Phe Ser 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Gly Val Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Phe Asp Ser Ile Ser Gly Glu Leu Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Val 
        115                 120                 125             


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ala Thr Val Met 
145                 150                 155                 160 


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
                165                 170                 175     


Ile Thr Ala Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val Val 
    210                 215                 220                 


Val Phe Thr Ser Gln Asp Arg Ile Tyr Tyr Tyr Arg Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser 
                245             


<210>  75
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  75

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Tyr Arg Gly 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Asp Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Val Trp His Arg Arg Thr Gly Val Leu Leu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Val 
        115                 120                 125             


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ala Thr Val Met 
145                 150                 155                 160 


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
                165                 170                 175     


Ile Thr Ala Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Val Val 
    210                 215                 220                 


Val Phe Thr Ser Gln Asp Arg Ile Tyr Tyr Tyr Arg Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser 
                245             


