                         SEQUENCE LISTING

<110>  University of Utah Research Foundation
 
<120>  SELECTIVE PENICILLAMINE SUBSTITUTION ENABLES DEVELOPMENT OF A 
       POTENT ANALGESIC PEPTIDE THAT ACTS THROUGH A NON-OPIOID BASED 
       MECHANISM

<130>  00846-U6463.PCT

<150>  63/196,655
<151>  2021-06-03

<150>  63/197,931
<151>  2021-06-07

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Conus Regius

<400>  1

Gly Cys Cys Ser Asp Pro Arg Cys Arg Tyr Arg Cys Arg 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-Iodo-tyrosine

<400>  2

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen, L-Cy

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  L-Arg, D-Arg, L-Cit, D-Cit

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-chloro-tyrosine, 3-fluoro-tyrosine, 3-iodo-tyrosine, 
       3-bromo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any Amino acid other than Cysteine

<400>  3

Gly Cys Xaa Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-chloro-tyrosine, 3-fluoro-tyrosine, 3-iodo-tyrosine, 
       3-bromo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any Amino acid other than Cysteine

<400>  4

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any Amino acid other than Cysteine

<400>  5

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any Amino acid other than Cysteine

<400>  6

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  3-chloro-betahomotyrosine, 3-fluoro-betahomotyrosine, 
       3-iodo-betahomotyrosine, 3-bromo-betahomotyrosine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any Amino acid other than Cysteine

<400>  7

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  betahomotyrosine

<400>  8

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Arg 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  3-chloro-betahomotyrosine, 3-fluoro-betahomotyrosine, 
       3-iodo-betahomotyrosine, 3-bromo-betahomotyrosine

<400>  9

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Arg 
1               5                   10                  


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  L-Arg, D-Arg, L-Cit, D-Cit

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  L-Arg, D-Arg

<400>  10

Gly Cys Xaa Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  L-Arg, D-Arg, L-Cit, D-Cit

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  3-chloro-beta-3-homo-tyrosine, 3-fluoro-beta-3-homo-tyrosine, 
       3-iodo-beta-3-homo-tyrosine, 3-bromo-beta-3-homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  L-Arg, D-Arg

<400>  11

Gly Cys Xaa Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<400>  12

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Arg 
1               5                   10                  


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<400>  13

Gly Xaa Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<400>  14

Gly Cys Xaa Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<400>  15

Gly Cys Cys Thr Asp Pro Arg Xaa Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  L-Pen, D-Pen

<400>  16

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Xaa Tyr 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<400>  17

Gly Xaa Cys Thr Asp Pro Arg Xaa Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  L-Pen, D-Pen

<400>  18

Gly Cys Xaa Thr Asp Pro Arg Cys Xaa Xaa Gln Xaa Tyr 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<400>  19

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr 
1               5                   10              


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<400>  20

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr Arg 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<400>  21

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr Arg 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<400>  22

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Arg 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<400>  23

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Lys 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Orn

<400>  24

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Citrulline

<400>  25

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L-Pen, D-Pen

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<400>  26

Gly Cys Xaa Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Glu 
1               5                   10                  


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-3-homo-tyrosine

<400>  27

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Arg 
1               5                   10                  


