                         SEQUENCE LISTING

<110>  Merus N.V.
 
<120>  New NRG1 fusions, fusion junctions and methods for detecting them

<130>  P130410PC00

<140>  PCT/NL2022/050302
<141>  2022-06-01

<150>  NL 2028384
<151>  2021-06-03

<150>  NL 2030006
<151>  2021-12-03

<160>  942   

<170>  PatentIn version 3.5

<210>  1
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  1
caggtcctga gcctcgagcc gcagcacgag ctcaaattcc gag                         43


<210>  2
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  2
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt t                51


<210>  3
<211>  94
<212>  DNA
<213>  Homo sapiens

<400>  3
caggtcctga gcctcgagcc gcagcacgag ctcaaattcc gagccttgcc tccccgattg       60

aaagagatga aaagccagga atcggctgca ggtt                                   94


<210>  4
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Leu Ser Leu Glu Pro Gln His Glu Leu Lys Phe Arg Ala Leu 
1               5                   10                  15      


Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly 
            20                  25                  30      


<210>  5
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  5
agcttcaaac atagtgggga aagctcactc ggattatatg ctgtatgtat acg              53


<210>  6
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  6
ctacatctac atccaccact gggacaagcc at                                     32


<210>  7
<211>  85
<212>  DNA
<213>  Homo sapiens

<400>  7
agcttcaaac atagtgggga aagctcactc ggattatatg ctgtatgtat acgctacatc       60

tacatccacc actgggacaa gccat                                             85


<210>  8
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val 
1               5                   10                  15      


Tyr Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
            20                  25              


<210>  9
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  9
gacgaagaca gtccctggat caccgacagc acagacagaa tccctgctac ca               52


<210>  10
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  10
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaact         58


<210>  11
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  11
gacgaagaca gtccctggat caccgacagc acagacagaa tccctgctac caccttgcct       60

ccccgattga aagagatgaa aagccaggaa tcggctgcag gttccaaact                 110


<210>  12
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Glu Asp Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala 
1               5                   10                  15      


Thr Thr Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
            20                  25                  30          


Ala Gly Ser Lys 
        35      


<210>  13
<211>  53
<212>  DNA
<213>  Homo sapiens

<400>  13
ccgcatcggc gaccttcagg ccttccaggg ccacggcgcg ggcaacctgg cgg              53


<210>  14
<211>  35
<212>  DNA
<213>  Homo sapiens

<400>  14
catctacatc tacatccacc actgggacaa gccat                                  35


<210>  15
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  15
ccgcatcggc gaccttcagg ccttccaggg ccacggcgcg ggcaacctgg cggcatctac       60

atctacatcc accactggga caagccat                                          88


<210>  16
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu 
1               5                   10                  15      


Ala Ala Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
            20                  25                  


<210>  17
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  17
agtccccgcc cctggagccg gcggcgcagg gcgcagcttc ccgccgccag agcgggccag       60

cctgctgcgt gcgtgcgtgt gtacgactct gcgtgcgtgc gtgcgtgcgt gcgtgccgtc      120

agctcgccgg gcaccgcggc ctcgccctcg ccctccgccc ctgcgcctgc accgcgtaga      180

ccgacccccc cccagcgcgc ccacccggta gaggaccccc gcccgtgccc cgaccggtcc      240

ccgccttttt gtaaaactta aagcgggcgc agcattaacg cttcccgccc cggtgacctc      300

tcaggggtct ccccgccaaa ggtgctccgc cgctaaggaa catggcgaag gtggagcagg      360

tcctgagcct cgagccgcag cacgagctca aattccgag                             399


<210>  18
<211>  153
<212>  DNA
<213>  Homo sapiens

<400>  18
gtcccttcac cgatgttgtc accaccaacc taaagcttgg caacccgaca gaccgaaatg       60

tgtgttttaa ggtgaagact acagcaccac gtaggtactg tgtgaggccc aacagcggaa      120

tcatcgatgc aggggcctca attaatgtat ctg                                   153


<210>  19
<211>  104
<212>  DNA
<213>  Homo sapiens

<400>  19
tgatgttaca gcctttcgat tatgatccca atgagaaaag taaacacaag tttatggttc       60

agtctatgtt tgctccaact gacacttcag atatggaagc agta                       104


<210>  20
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  20
tggaaggagg caaaaccgga agaccttatg gattcaaaac ttagatgtgt gtttgaattg       60

ccagcagaga atgataaacc a                                                 81


<210>  21
<211>  177
<212>  DNA
<213>  Homo sapiens

<400>  21
catgatgtag aaataaataa aattatatcc acaactgcat caaagacaga aacaccaata       60

gtgtctaagt ctctgagttc ttctttggat gacaccgaag ttaagaaggt tatggaagaa      120

tgtaagaggc tgcaaggtga agttcagagg ctacgggagg agaacaagca gttcaag         177


<210>  22
<211>  7035
<212>  DNA
<213>  Homo sapiens

<400>  22
gaagaagatg gactgcggat gaggaagaca gtgcagagca acagccccat ttcagcatta       60

gccccaactg ggaaggaaga aggccttagc acccggctct tggctctggt ggttttgttc      120

tttatcgttg gtgtaattat tgggaagatt gccttgtaga ggtagcatgc acaggatggt      180

aaattggatt ggtggatcca ccatatcatg ggatttaaat ttatcataac catgtgtaaa      240

aagaaattaa tgtatgatga catctcacag gtcttgcctt taaattaccc ctccctgcac      300

acacatacac agatacacac acacaaatat aatgtaacga tcttttagaa agttaaaaat      360

gtatagtaac tgattgaggg ggaaaagaat gatctttatt aatgacaagg gaaaccatga      420

gtaatgccac aatggcatat tgtaaatgtc attttaaaca ttggtaggcc ttggtacatg      480

atgctggatt acctctctta aaatgacacc cttcctcgcc tgttggtgct ggcccttggg      540

gagctggagc ccagcatgct ggggagtgcg gtcagctcca cacagtagtc cccacgtggc      600

ccactcccgg cccaggctgc tttccgtgtc ttcagttctg tccaagccat cagctccttg      660

ggactgatga acagagtcag aagcccaaag gaattgcact gtggcagcat cagacgtact      720

cgtcataagt gagaggcgtg tgttgactga ttgacccagc gctttggaaa taaatggcag      780

tgctttgttc acttaaaggg accaagctaa atttgtattg gttcatgtag tgaagtcaaa      840

ctgttattca gagatgttta atgcatattt aacttattta atgtatttca tctcatgttt      900

tcttattgtc acaagagtac agttaatgct gcgtgctgct gaactctgtt gggtgaactg      960

gtattgctgc tggagggctg tgggctcctc tgtctctgga gagtctggtc atgtggaggt     1020

ggggtttatt gggatgctgg agaagagctg ccaggaagtg ttttttctgg gtcagtaaat     1080

aacaactgtc atagggaggg aaattctcag tagtgacagt caactctagg ttaccttttt     1140

taatgaagag tagtcagtct tctagattgt tcttatacca cctctcaacc attactcaca     1200

cttccagcgc ccaggtccaa gtctgagcct gacctcccct tggggaccta gcctggagtc     1260

aggacaaatg gatcgggctg cagagggtta gaagcgaggg caccagcagt tgtgggtggg     1320

gagcaaggga agagagaaac tcttcagcga atccttctag tactagttga gagtttgact     1380

gtgaattaat tttatgccat aaaagaccaa cccagttctg tttgactatg tagcatcttg     1440

aaaagaaaaa ttataataaa gccccaaaat taagaattct tttgtcattt tgtcacattt     1500

gctctatggg gggaattatt attttatcat ttttattatt ttgccattgg aaggttaact     1560

ttaaaatgag ccctatcact gagaaatacg tgtttcatga tttaactctg tgtgtgtgtg     1620

tgtgtgtgtg tgtgtgtgtg tgtgtatttt ttttttggtt gtcttcagct gacagtatga     1680

aaaatgaaac tgctgaaaaa gctgagcacc tggtcaccct tggccttcca ttgctttggc     1740

cttcagtaaa aagcagcctc ccttctaggt cagggaacca tgccattgag actagtaacg     1800

ggcgttctgg gcacagtccc actgtgcaca ggtttgagag gacaagttca tcagaaggaa     1860

ggcagtcctt agaagtcaca tacgttgagc cacgttgctc ctaagcctgg ctctgtcaag     1920

ctgggtcagg ggccttgaaa ctggagaagt ggaagtctat ggttggtctg agtaagtaac     1980

ttcctgtctt catgaaaaaa gttgactttg aatcccaggt actcacagaa atggtgaaca     2040

gacttagttg ttacccaggc acccatggat tgtgttgagt gtgcagacag ggaggccacc     2100

ccaataggaa ttcgtctcca ggatttttcc catgtgtccc ccagtactta taaaagggag     2160

tgaaaagacc gagctgtaag gcatgtgcct tctgccacct gactttccgt gaggggacta     2220

aaatttacta attgtagttg ctgcagccag ttaagtcctg tagcttccag gccctcatgt     2280

ctttgatagg agagtgctta ggtggtcccc aacagtgcct aggggtacag tacagtccca     2340

ttacactaga gcagggctct atttattttt aaaggatatg gccgtgtgtt ttgataaaac     2400

tttattcaca aaaacagccg ggtcatggga tttggcttgt gagtctgtaa cagttcttaa     2460

aaagaatatc tgagaaacta ctctgtttta gacctttgaa ggtgatttag agttttgtgt     2520

acatctagga gaaggtgttc agcttctcag aggatgtgga cattttggtt gcagctaaaa     2580

atcagtctct gaagtctctc tcccttctag aggttaggac ttggtgaaca tgtttgtggg     2640

ccttttgact gagtggcaga aggaaactgc tcaggaagag aaacaggtga ctgatgggaa     2700

ggttgattat tttctcagtc atcctggcag ccaaaaatgt gccaggaaaa gaaagaatgt     2760

ggagcacgcg tggctcctgg aggacttgga gatgcatgca catttagggt gttttcccta     2820

gaattacata atgaaaaaaa gaataaggca aagaggaggt gaatatgggg cctgtcacaa     2880

cggcctgccc tgccccaaga gggttaagag tcagataatc gggacgaaac tggcatggaa     2940

agagcgagcc tagggaggat gccgctgggc agtgtgcatg ggggagctgc tgccaggctg     3000

ccctccagtc tgctcctgtg gttactggct ccacagcacc tcagagaggg cggccctggc     3060

ttcagaaatg ccagccatag tgctcacaaa tgcagaagag atggaagcgg tgacagaatc     3120

ctgaaagttt ttattgattg aagttttaaa ttggtaactt aagcttcctt ggcacgatac     3180

aaaatacctc ttaaagacag caggcttttt tatttgtagg tgtgaggaac tggctttaac     3240

ttttttctcc tcctagtttg catgttttcc ttctctcgtc ttctgaactg ctggcaccag     3300

cagtaataca tactgataaa atcaaaattg atttttacca gtggccagtt tatggctaga     3360

gagacgactt atacctccat aacacagaag ggggaaaaat gaagaacctc cagtgatccg     3420

tgaaaaccta aacgctttca aacaaatccc aggaacagaa ttgctatcga aagatatcat     3480

tgcccagttt gcaggctatg ttgagtcaga tagaactgaa tgtagtgaga gctcagagct     3540

acagagcctt tcagatgaat ttgaaaacag actctgtgtg tgtgtgcatg tgtgcatgtg     3600

tgcatgtgtg gcatatgtgc cgtatgtcag tagcttgaca gttttcaaat cgtgcctata     3660

tttttttgca tacacaaatt tttgtgtttg caaactcaga atccatgcca aaatacaatg     3720

ttatatgtca ttttcagctc cttctctaaa ggaatggccc atttctcatt gtagtttgag     3780

aaatacatgt atgaagagat aggggtcttg ggcttcccag tgtcactttg aacacctgaa     3840

taacatttaa ctcctgagac cttctcggtg tagaggccac tgcttccccc tgctggagat     3900

ggcatttcat tgaagggcct ctcgtggctt tccctgcccc cggctgtctg gcctgaagaa     3960

ggagaaagaa ccaaactgaa ctatgaaaag ttaccactct gaggagacct ctcttaatta     4020

acacttgggg ccatgtttgc tgttgttgag aaggagtgtt ctcaaagatg agctggaatg     4080

gaattgtatt tagaaaggcc cctgcaaagt atatagatgg atgactctag ttcatgacat     4140

acaaatccca taaggccaac gaccactctt ctggaacacc aagagcagct ctgagatcat     4200

gctggcccta cgcgaattga gtttctgtgg cctaattgga tttggagaac gccttccctg     4260

gccccttttc ctcagacaga tctgctctga taggaacctt ttcaagaaag ttactgttgt     4320

ttcaatgcca ctccttacct gtatagaaca tttccaatac attcgctcat tgaacttaat     4380

ccttgcaact gtgactgggg ggtagatggc tctgtttgca tacgaagaaa taaaggctcc     4440

aggaggttaa atcgggcaac tttttagaac taaatcagtc tctgtaaggc ctacattgct     4500

aagataccat ttcagctctg aaaatctgct tcagggaagt gagtggatga ggccttcctg     4560

cctcagctac tctgcccgtc tgtacatctt ttgtgtctgc ctccgtacct tattcagtta     4620

ttttcacact aaagtaagta gaattaagac tgtagttcag atgctttttc tttttctgtt     4680

ggaaactgaa cacactacag acagtgaaaa aaggtacata ttccattttc tcattgcctg     4740

aagatctctg ctgatgctcc tggagaatga ctttgggggc tttagaaaga atattgccag     4800

tccgtctcgg caaggagatg atgggagcgc tttatatgga ggctttacat gacttgtaaa     4860

ttaaatgtga atgagggcag ttgattaaaa ttggtattac agaagggccc tgctgaggtt     4920

tgaaaacagc tgagctgctg atgtctcagg cctttccctg aattagcact gcggttctcc     4980

aggatatcag caaagagggc aagtaataga agcccctgat aaggagcgtc agccgacagg     5040

caagcttggg aggctgtggg aatgggtctg cccccagctt cacagacctc ttcctccagc     5100

ctctgaatcc cattagccac agcctagaac attagctgag ctgcacaagc tcacccaccc     5160

ctgtgccagg gggccctgac ctccctccat gccatgtttt tggctgtatc tacggcactt     5220

aacaataggg gctttttatt ttcattacag agatattttg aaaaatttaa aagacatgaa     5280

ctcacataaa cagttatgga tgatagttaa aagagaaacg ggtggaggtg gatgagaggt     5340

tgtcttcatg aatataatta cttgagattt ttttttctta atggaattag tttattagaa     5400

aatgtctgtg ttaaatccgt agaaaaggaa gaaaagtgta gcaacaaaaa tgtagccatt     5460

atctaacttg ccataaatat ttgcagttat gataccttgg aatgttgcca cgatatggat     5520

tgctttgatt aaaagatgtc agttgaataa aacagtactg tgggagaatc gctttctgct     5580

gctagataaa tgctgatgtt tatttttaaa ccaggaaaca ttgatcctgt aacaatgccc     5640

gattacaatt gctttattac accccagggc tgatggagat gtaatcactt ggctaatgga     5700

tgtgggtgca ggacagatgc tcgcttgctg gcctgctttc ctgcttgcat tctgatgagc     5760

tgcaggagtg cgcctggcct tctgcaggtg gagctgctgt cagagcttcg tttcactgat     5820

acccaaagcc atgtctgact gaaataaaac aggttccctt tttttttccc tttggaaaat     5880

gccaactaag ggagactaat cagatatctt aacacaattt catccaggct tagtgctaac     5940

aagattgcgg ggctttttag ggtttaagaa gatgagaaat gagtgtgcac gtttcacacg     6000

ttgacttgcc ggtttttcca tgtcatacaa aaaagtcctg gctgtttctc cgaactggct     6060

gcctgcattc ccgtctttct tttgttttta agaaatagac tgaattcagc tgttaatcct     6120

ctagtacagt atccatgtta aaatgttttt ccattgcatc ttttatgtga attcaaaggt     6180

cagaatttat tgtctgtgat attgagacca tgtgtacaag aactactttt tgcttttcat     6240

cattcactcc ttagcaaacg tttcgtaagt accctctgtc tgtttgctac tatatgaggt     6300

gctgcgaaat tagtgggcgt ggctttttat atttttcatt cgtgtgtagc ctaagtaagg     6360

tgactcaaga tgatacaccg agagaaaaat gcaaaatata tttggttctc atttctgttg     6420

ctgtcgtttc ctttttaaag acgatttatc aactgctgcc atttggaact tcctataaga     6480

aactaaaaat gatctatttc agtgttcctt tcgcctttcc tctgctttct gaataaatgg     6540

tttcagtaac ccatgctgtt ctctccctat tctacgtctt tctccctatg ttgaaaaaag     6600

attcccacag tttctgatgt gtgtgtttat agtcttcaat gtatgttaac atgttaggaa     6660

ctgagtatct taagagatgt cttagaatgc tttagttttc ataatttgtc ctttatgtat     6720

ttttcattgt atttgctgtt ttgacatgga agtaatttaa aaagttggtg caggaaagga     6780

ctctttactg ttgcacattt tggttttctg atatgtaata aattcatggc ttggcagctg     6840

acatgatgtt tcccagagag aaggagatgt atttctgcag ggtccagacc aaaagagcca     6900

tttacagcat gttctcccat gttccattat cagcctgatg aaacctgccc tgccaaggca     6960

taaacttttg tactagctgt ctccatatta tgttcaataa attctgtgct ctgaatatat     7020

ttaaaaaaaa aaaaa                                                      7035


<210>  23
<211>  7949
<212>  DNA
<213>  Homo sapiens

<400>  23
agtccccgcc cctggagccg gcggcgcagg gcgcagcttc ccgccgccag agcgggccag       60

cctgctgcgt gcgtgcgtgt gtacgactct gcgtgcgtgc gtgcgtgcgt gcgtgccgtc      120

agctcgccgg gcaccgcggc ctcgccctcg ccctccgccc ctgcgcctgc accgcgtaga      180

ccgacccccc cccagcgcgc ccacccggta gaggaccccc gcccgtgccc cgaccggtcc      240

ccgccttttt gtaaaactta aagcgggcgc agcattaacg cttcccgccc cggtgacctc      300

tcaggggtct ccccgccaaa ggtgctccgc cgctaaggaa catggcgaag gtggagcagg      360

tcctgagcct cgagccgcag cacgagctca aattccgagg tcccttcacc gatgttgtca      420

ccaccaacct aaagcttggc aacccgacag accgaaatgt gtgttttaag gtgaagacta      480

cagcaccacg taggtactgt gtgaggccca acagcggaat catcgatgca ggggcctcaa      540

ttaatgtatc tgtgatgtta cagcctttcg attatgatcc caatgagaaa agtaaacaca      600

agtttatggt tcagtctatg tttgctccaa ctgacacttc agatatggaa gcagtatgga      660

aggaggcaaa accggaagac cttatggatt caaaacttag atgtgtgttt gaattgccag      720

cagagaatga taaaccacat gatgtagaaa taaataaaat tatatccaca actgcatcaa      780

agacagaaac accaatagtg tctaagtctc tgagttcttc tttggatgac accgaagtta      840

agaaggttat ggaagaatgt aagaggctgc aaggtgaagt tcagaggcta cgggaggaga      900

acaagcagtt caaggaagaa gatggactgc ggatgaggaa gacagtgcag agcaacagcc      960

ccatttcagc attagcccca actgggaagg aagaaggcct tagcacccgg ctcttggctc     1020

tggtggtttt gttctttatc gttggtgtaa ttattgggaa gattgccttg tagaggtagc     1080

atgcacagga tggtaaattg gattggtgga tccaccatat catgggattt aaatttatca     1140

taaccatgtg taaaaagaaa ttaatgtatg atgacatctc acaggtcttg cctttaaatt     1200

acccctccct gcacacacat acacagatac acacacacaa atataatgta acgatctttt     1260

agaaagttaa aaatgtatag taactgattg agggggaaaa gaatgatctt tattaatgac     1320

aagggaaacc atgagtaatg ccacaatggc atattgtaaa tgtcatttta aacattggta     1380

ggccttggta catgatgctg gattacctct cttaaaatga cacccttcct cgcctgttgg     1440

tgctggccct tggggagctg gagcccagca tgctggggag tgcggtcagc tccacacagt     1500

agtccccacg tggcccactc ccggcccagg ctgctttccg tgtcttcagt tctgtccaag     1560

ccatcagctc cttgggactg atgaacagag tcagaagccc aaaggaattg cactgtggca     1620

gcatcagacg tactcgtcat aagtgagagg cgtgtgttga ctgattgacc cagcgctttg     1680

gaaataaatg gcagtgcttt gttcacttaa agggaccaag ctaaatttgt attggttcat     1740

gtagtgaagt caaactgtta ttcagagatg tttaatgcat atttaactta tttaatgtat     1800

ttcatctcat gttttcttat tgtcacaaga gtacagttaa tgctgcgtgc tgctgaactc     1860

tgttgggtga actggtattg ctgctggagg gctgtgggct cctctgtctc tggagagtct     1920

ggtcatgtgg aggtggggtt tattgggatg ctggagaaga gctgccagga agtgtttttt     1980

ctgggtcagt aaataacaac tgtcataggg agggaaattc tcagtagtga cagtcaactc     2040

taggttacct tttttaatga agagtagtca gtcttctaga ttgttcttat accacctctc     2100

aaccattact cacacttcca gcgcccaggt ccaagtctga gcctgacctc cccttgggga     2160

cctagcctgg agtcaggaca aatggatcgg gctgcagagg gttagaagcg agggcaccag     2220

cagttgtggg tggggagcaa gggaagagag aaactcttca gcgaatcctt ctagtactag     2280

ttgagagttt gactgtgaat taattttatg ccataaaaga ccaacccagt tctgtttgac     2340

tatgtagcat cttgaaaaga aaaattataa taaagcccca aaattaagaa ttcttttgtc     2400

attttgtcac atttgctcta tggggggaat tattatttta tcatttttat tattttgcca     2460

ttggaaggtt aactttaaaa tgagccctat cactgagaaa tacgtgtttc atgatttaac     2520

tctgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tttttttttt ggttgtcttc     2580

agctgacagt atgaaaaatg aaactgctga aaaagctgag cacctggtca cccttggcct     2640

tccattgctt tggccttcag taaaaagcag cctcccttct aggtcaggga accatgccat     2700

tgagactagt aacgggcgtt ctgggcacag tcccactgtg cacaggtttg agaggacaag     2760

ttcatcagaa ggaaggcagt ccttagaagt cacatacgtt gagccacgtt gctcctaagc     2820

ctggctctgt caagctgggt caggggcctt gaaactggag aagtggaagt ctatggttgg     2880

tctgagtaag taacttcctg tcttcatgaa aaaagttgac tttgaatccc aggtactcac     2940

agaaatggtg aacagactta gttgttaccc aggcacccat ggattgtgtt gagtgtgcag     3000

acagggaggc caccccaata ggaattcgtc tccaggattt ttcccatgtg tcccccagta     3060

cttataaaag ggagtgaaaa gaccgagctg taaggcatgt gccttctgcc acctgacttt     3120

ccgtgagggg actaaaattt actaattgta gttgctgcag ccagttaagt cctgtagctt     3180

ccaggccctc atgtctttga taggagagtg cttaggtggt ccccaacagt gcctaggggt     3240

acagtacagt cccattacac tagagcaggg ctctatttat ttttaaagga tatggccgtg     3300

tgttttgata aaactttatt cacaaaaaca gccgggtcat gggatttggc ttgtgagtct     3360

gtaacagttc ttaaaaagaa tatctgagaa actactctgt tttagacctt tgaaggtgat     3420

ttagagtttt gtgtacatct aggagaaggt gttcagcttc tcagaggatg tggacatttt     3480

ggttgcagct aaaaatcagt ctctgaagtc tctctccctt ctagaggtta ggacttggtg     3540

aacatgtttg tgggcctttt gactgagtgg cagaaggaaa ctgctcagga agagaaacag     3600

gtgactgatg ggaaggttga ttattttctc agtcatcctg gcagccaaaa atgtgccagg     3660

aaaagaaaga atgtggagca cgcgtggctc ctggaggact tggagatgca tgcacattta     3720

gggtgttttc cctagaatta cataatgaaa aaaagaataa ggcaaagagg aggtgaatat     3780

ggggcctgtc acaacggcct gccctgcccc aagagggtta agagtcagat aatcgggacg     3840

aaactggcat ggaaagagcg agcctaggga ggatgccgct gggcagtgtg catgggggag     3900

ctgctgccag gctgccctcc agtctgctcc tgtggttact ggctccacag cacctcagag     3960

agggcggccc tggcttcaga aatgccagcc atagtgctca caaatgcaga agagatggaa     4020

gcggtgacag aatcctgaaa gtttttattg attgaagttt taaattggta acttaagctt     4080

ccttggcacg atacaaaata cctcttaaag acagcaggct tttttatttg taggtgtgag     4140

gaactggctt taactttttt ctcctcctag tttgcatgtt ttccttctct cgtcttctga     4200

actgctggca ccagcagtaa tacatactga taaaatcaaa attgattttt accagtggcc     4260

agtttatggc tagagagacg acttatacct ccataacaca gaagggggaa aaatgaagaa     4320

cctccagtga tccgtgaaaa cctaaacgct ttcaaacaaa tcccaggaac agaattgcta     4380

tcgaaagata tcattgccca gtttgcaggc tatgttgagt cagatagaac tgaatgtagt     4440

gagagctcag agctacagag cctttcagat gaatttgaaa acagactctg tgtgtgtgtg     4500

catgtgtgca tgtgtgcatg tgtggcatat gtgccgtatg tcagtagctt gacagttttc     4560

aaatcgtgcc tatatttttt tgcatacaca aatttttgtg tttgcaaact cagaatccat     4620

gccaaaatac aatgttatat gtcattttca gctccttctc taaaggaatg gcccatttct     4680

cattgtagtt tgagaaatac atgtatgaag agataggggt cttgggcttc ccagtgtcac     4740

tttgaacacc tgaataacat ttaactcctg agaccttctc ggtgtagagg ccactgcttc     4800

cccctgctgg agatggcatt tcattgaagg gcctctcgtg gctttccctg cccccggctg     4860

tctggcctga agaaggagaa agaaccaaac tgaactatga aaagttacca ctctgaggag     4920

acctctctta attaacactt ggggccatgt ttgctgttgt tgagaaggag tgttctcaaa     4980

gatgagctgg aatggaattg tatttagaaa ggcccctgca aagtatatag atggatgact     5040

ctagttcatg acatacaaat cccataaggc caacgaccac tcttctggaa caccaagagc     5100

agctctgaga tcatgctggc cctacgcgaa ttgagtttct gtggcctaat tggatttgga     5160

gaacgccttc cctggcccct tttcctcaga cagatctgct ctgataggaa ccttttcaag     5220

aaagttactg ttgtttcaat gccactcctt acctgtatag aacatttcca atacattcgc     5280

tcattgaact taatccttgc aactgtgact ggggggtaga tggctctgtt tgcatacgaa     5340

gaaataaagg ctccaggagg ttaaatcggg caacttttta gaactaaatc agtctctgta     5400

aggcctacat tgctaagata ccatttcagc tctgaaaatc tgcttcaggg aagtgagtgg     5460

atgaggcctt cctgcctcag ctactctgcc cgtctgtaca tcttttgtgt ctgcctccgt     5520

accttattca gttattttca cactaaagta agtagaatta agactgtagt tcagatgctt     5580

tttctttttc tgttggaaac tgaacacact acagacagtg aaaaaaggta catattccat     5640

tttctcattg cctgaagatc tctgctgatg ctcctggaga atgactttgg gggctttaga     5700

aagaatattg ccagtccgtc tcggcaagga gatgatggga gcgctttata tggaggcttt     5760

acatgacttg taaattaaat gtgaatgagg gcagttgatt aaaattggta ttacagaagg     5820

gccctgctga ggtttgaaaa cagctgagct gctgatgtct caggcctttc cctgaattag     5880

cactgcggtt ctccaggata tcagcaaaga gggcaagtaa tagaagcccc tgataaggag     5940

cgtcagccga caggcaagct tgggaggctg tgggaatggg tctgccccca gcttcacaga     6000

cctcttcctc cagcctctga atcccattag ccacagccta gaacattagc tgagctgcac     6060

aagctcaccc acccctgtgc cagggggccc tgacctccct ccatgccatg tttttggctg     6120

tatctacggc acttaacaat aggggctttt tattttcatt acagagatat tttgaaaaat     6180

ttaaaagaca tgaactcaca taaacagtta tggatgatag ttaaaagaga aacgggtgga     6240

ggtggatgag aggttgtctt catgaatata attacttgag attttttttt cttaatggaa     6300

ttagtttatt agaaaatgtc tgtgttaaat ccgtagaaaa ggaagaaaag tgtagcaaca     6360

aaaatgtagc cattatctaa cttgccataa atatttgcag ttatgatacc ttggaatgtt     6420

gccacgatat ggattgcttt gattaaaaga tgtcagttga ataaaacagt actgtgggag     6480

aatcgctttc tgctgctaga taaatgctga tgtttatttt taaaccagga aacattgatc     6540

ctgtaacaat gcccgattac aattgcttta ttacacccca gggctgatgg agatgtaatc     6600

acttggctaa tggatgtggg tgcaggacag atgctcgctt gctggcctgc tttcctgctt     6660

gcattctgat gagctgcagg agtgcgcctg gccttctgca ggtggagctg ctgtcagagc     6720

ttcgtttcac tgatacccaa agccatgtct gactgaaata aaacaggttc cctttttttt     6780

tccctttgga aaatgccaac taagggagac taatcagata tcttaacaca atttcatcca     6840

ggcttagtgc taacaagatt gcggggcttt ttagggttta agaagatgag aaatgagtgt     6900

gcacgtttca cacgttgact tgccggtttt tccatgtcat acaaaaaagt cctggctgtt     6960

tctccgaact ggctgcctgc attcccgtct ttcttttgtt tttaagaaat agactgaatt     7020

cagctgttaa tcctctagta cagtatccat gttaaaatgt ttttccattg catcttttat     7080

gtgaattcaa aggtcagaat ttattgtctg tgatattgag accatgtgta caagaactac     7140

tttttgcttt tcatcattca ctccttagca aacgtttcgt aagtaccctc tgtctgtttg     7200

ctactatatg aggtgctgcg aaattagtgg gcgtggcttt ttatattttt cattcgtgtg     7260

tagcctaagt aaggtgactc aagatgatac accgagagaa aaatgcaaaa tatatttggt     7320

tctcatttct gttgctgtcg tttccttttt aaagacgatt tatcaactgc tgccatttgg     7380

aacttcctat aagaaactaa aaatgatcta tttcagtgtt cctttcgcct ttcctctgct     7440

ttctgaataa atggtttcag taacccatgc tgttctctcc ctattctacg tctttctccc     7500

tatgttgaaa aaagattccc acagtttctg atgtgtgtgt ttatagtctt caatgtatgt     7560

taacatgtta ggaactgagt atcttaagag atgtcttaga atgctttagt tttcataatt     7620

tgtcctttat gtatttttca ttgtatttgc tgttttgaca tggaagtaat ttaaaaagtt     7680

ggtgcaggaa aggactcttt actgttgcac attttggttt tctgatatgt aataaattca     7740

tggcttggca gctgacatga tgtttcccag agagaaggag atgtatttct gcagggtcca     7800

gaccaaaaga gccatttaca gcatgttctc ccatgttcca ttatcagcct gatgaaacct     7860

gccctgccaa ggcataaact tttgtactag ctgtctccat attatgttca ataaattctg     7920

tgctctgaat atatttaaaa aaaaaaaaa                                       7949


<210>  24
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Lys Val Glu Gln Val Leu Ser Leu Glu Pro Gln His Glu Leu 
1               5                   10                  15      


Lys Phe Arg 
            


<210>  25
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  25

Pro Phe Thr Asp Val Val Thr Thr Asn Leu Lys Leu Gly Asn Pro Thr 
1               5                   10                  15      


Asp Arg Asn Val Cys Phe Lys Val Lys Thr Thr Ala Pro Arg Arg Tyr 
            20                  25                  30          


Cys Val Arg Pro Asn Ser Gly Ile Ile Asp Ala Gly Ala Ser Ile Asn 
        35                  40                  45              


Val Ser 
    50  


<210>  26
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Leu Gln Pro Phe Asp Tyr Asp Pro Asn Glu Lys Ser Lys His Lys 
1               5                   10                  15      


Phe Met Val Gln Ser Met Phe Ala Pro Thr Asp Thr Ser Asp Met Glu 
            20                  25                  30          


Ala Val 
        


<210>  27
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  27

Trp Lys Glu Ala Lys Pro Glu Asp Leu Met Asp Ser Lys Leu Arg Cys 
1               5                   10                  15      


Val Phe Glu Leu Pro Ala Glu Asn Asp Lys Pro 
            20                  25          


<210>  28
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  28

His Asp Val Glu Ile Asn Lys Ile Ile Ser Thr Thr Ala Ser Lys Thr 
1               5                   10                  15      


Glu Thr Pro Ile Val Ser Lys Ser Leu Ser Ser Ser Leu Asp Asp Thr 
            20                  25                  30          


Glu Val Lys Lys Val Met Glu Glu Cys Lys Arg Leu Gln Gly Glu Val 
        35                  40                  45              


Gln Arg Leu Arg Glu Glu Asn Lys Gln Phe Lys 
    50                  55                  


<210>  29
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Glu Asp Gly Leu Arg Met Arg Lys Thr Val Gln Ser Asn Ser Pro 
1               5                   10                  15      


Ile Ser Ala Leu Ala Pro Thr Gly Lys Glu Glu Gly Leu Ser Thr Arg 
            20                  25                  30          


Leu Leu Ala Leu Val Val Leu Phe Phe Ile Val Gly Val Ile Ile Gly 
        35                  40                  45              


Lys Ile Ala Leu 
    50          


<210>  30
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Lys Val Glu Gln Val Leu Ser Leu Glu Pro Gln His Glu Leu 
1               5                   10                  15      


Lys Phe Arg Gly Pro Phe Thr Asp Val Val Thr Thr Asn Leu Lys Leu 
            20                  25                  30          


Gly Asn Pro Thr Asp Arg Asn Val Cys Phe Lys Val Lys Thr Thr Ala 
        35                  40                  45              


Pro Arg Arg Tyr Cys Val Arg Pro Asn Ser Gly Ile Ile Asp Ala Gly 
    50                  55                  60                  


Ala Ser Ile Asn Val Ser Val Met Leu Gln Pro Phe Asp Tyr Asp Pro 
65                  70                  75                  80  


Asn Glu Lys Ser Lys His Lys Phe Met Val Gln Ser Met Phe Ala Pro 
                85                  90                  95      


Thr Asp Thr Ser Asp Met Glu Ala Val Trp Lys Glu Ala Lys Pro Glu 
            100                 105                 110         


Asp Leu Met Asp Ser Lys Leu Arg Cys Val Phe Glu Leu Pro Ala Glu 
        115                 120                 125             


Asn Asp Lys Pro His Asp Val Glu Ile Asn Lys Ile Ile Ser Thr Thr 
    130                 135                 140                 


Ala Ser Lys Thr Glu Thr Pro Ile Val Ser Lys Ser Leu Ser Ser Ser 
145                 150                 155                 160 


Leu Asp Asp Thr Glu Val Lys Lys Val Met Glu Glu Cys Lys Arg Leu 
                165                 170                 175     


Gln Gly Glu Val Gln Arg Leu Arg Glu Glu Asn Lys Gln Phe Lys Glu 
            180                 185                 190         


Glu Asp Gly Leu Arg Met Arg Lys Thr Val Gln Ser Asn Ser Pro Ile 
        195                 200                 205             


Ser Ala Leu Ala Pro Thr Gly Lys Glu Glu Gly Leu Ser Thr Arg Leu 
    210                 215                 220                 


Leu Ala Leu Val Val Leu Phe Phe Ile Val Gly Val Ile Ile Gly Lys 
225                 230                 235                 240 


Ile Ala Leu 
            


<210>  31
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  31
000

<210>  32
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  32
000

<210>  33
<211>  253
<212>  DNA
<213>  Homo sapiens

<400>  33
ggttgggctc gcggcgctgt gattggtctg cccggactcc gcctccagcg catgtcatta       60

gcatctcatt agctgtccgc tcgggctccg gaggcagcca acgccgccag tctgaggcag      120

gtgcccgaca tggcgagtgt agtgctgccg agcggatccc agtgtgcggc ggcagcggcg      180

gcggcggcgc ctcccgggct ccggctccgg cttctgctgt tgctcttctc cgccgcggca      240

ctgatcccca cag                                                         253


<210>  34
<211>  147
<212>  DNA
<213>  Homo sapiens

<400>  34
gtgatgggca gaatctgttt acgaaagacg tgacagtgat cgagggagag gttgcgacca       60

tcagttgcca agtcaataag agtgacgact ctgtgattca gctactgaat cccaacaggc      120

agaccattta tttcagggac ttcaggc                                          147


<210>  35
<211>  153
<212>  DNA
<213>  Homo sapiens

<400>  35
ctttgaagga cagcaggttt cagttgctga atttttctag cagtgaactc aaagtatcat       60

tgacaaacgt ctcaatttct gatgaaggaa gatacttttg ccagctctat accgatcccc      120

cacaggaaag ttacaccacc atcacagtcc tgg                                   153


<210>  36
<211>  138
<212>  DNA
<213>  Homo sapiens

<400>  36
tcccaccacg taatctgatg atcgatatcc agaaagacac tgcggtggaa ggtgaggaga       60

ttgaagtcaa ctgcactgct atggccagca agccagccac gactatcagg tggttcaaag      120

ggaacacaga gctaaaag                                                    138


<210>  37
<211>  159
<212>  DNA
<213>  Homo sapiens

<400>  37
gcaaatcgga ggtggaagag tggtcagaca tgtacactgt gaccagtcag ctgatgctga       60

aggtgcacaa ggaggacgat ggggtcccag tgatctgcca ggtggagcac cctgcggtca      120

ctggaaacct gcagacccag cggtatctag aagtacagt                             159


<210>  38
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  38
ataagcctca agtgcacatt cagatgactt atcctctaca aggcttaacc cgggaagggg       60

acgcgcttga gttaacatgt gaagccatcg ggaagcccca                            100


<210>  39
<211>  173
<212>  DNA
<213>  Homo sapiens

<400>  39
gcctgtgatg gtaacttggg tgagagtcga tgatgaaatg cctcaacacg ccgtactgtc       60

tgggcccaac ctgttcatca ataacctaaa caaaacagat aatggtacat accgctgtga      120

agcttcaaac atagtgggga aagctcactc ggattatatg ctgtatgtat acg             173


<210>  40
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  40
acacaacggc gacgacagaa ccagcagttc acg                                    33


<210>  41
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  41
gccttactca gttgcccaat tccgcagaag aactggacag tgaggacctc tcag             54


<210>  42
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  42
attcccgagc aggtgaagaa ggctcgatca gggcagtgga tcatgccgtg atcggtggcg       60

tcgtggcggt ggtggtgttc gccatgctgt gcttgctcat cattctgggg cgctattttg      120

ccagacataa ag                                                          132


<210>  43
<211>  2968
<212>  DNA
<213>  Homo sapiens

<400>  43
gtacatactt cactcatgaa gccaaaggag ccgatgacgc agcagacgca gacacagcta       60

taatcaatgc agaaggagga cagaacaact ccgaagaaaa gaaagagtac ttcatctaga      120

tcagcctttt tgtttcaatg aggtgtccaa ctggccctat ttagatgata aagagacagt      180

gatattggaa cttgcgagaa attcgtgtgt ttttttatga atgggtggaa aggtgtgaga      240

ctgggaaggc ttgggatttg ctgtgtaaaa aaaaaaaaaa tgttctttgg aaagtacact      300

ctgctgtttg acacctcttt tttcgtttgt ttgtttgttt aatttttatt tcttcctacc      360

aagtcaaact tggatacttg gatttagttt cagtagattg cagaaaattc tgtgccttgt      420

tttttgtttg tttgttgcgt tcctttcttt tccccctttg tgcacattta tttcctccct      480

ctaccccaat ttcggatttt ttccaaaatc tcccattttg gaatttgcct gctgggattc      540

cttagactct tttccttccc ttttctgttc tagtttttta cttttgttta tttttatggt      600

aactgctttc tgttccaaat tcagtttcat aaaaggagaa ccagcacagc ttagatttca      660

tagttcagaa tttagtgtat ccataatgca ttcttctctg ttgtcgtaaa gatttgggtg      720

aacaaacaat gaaaactctt tgctgctgcc catgtttcaa atacttagag cagtgaagac      780

tagaaaatta gactgtgatt cagaaaatgt tctgtttgct gtggaactac attactgtac      840

agggttatct gcaagtgagg tgtgtcacaa tgagattgaa tttcactgtc tttaattctg      900

tatctgtaga cggctcagta tagataccct acgctgtcca gaaaggtttg gggcagaaag      960

gactcctcct ttttccatgc cctaaacaga cctgacaggt gaggtctgtt ccttttatat     1020

aagtggacaa attttgagtt gccacaggag gggaagtagg gaggggggaa atacagttct     1080

gctctggttg tttctgttcc aaatgattcc atccaccttt cccaatcggc cttacttctc     1140

actaatttgt aggaaaaagc aagttcgtct gttgtgcgaa tgactgaatg ggacagagtt     1200

gatttttttt tttttttcct ttgtgcttag ttaggaaggc agtaggatgt ggcctgcatg     1260

tactgtatat tacagatatt tgtcatgctg ggatttccaa ctcgaatctg tgtgaaactt     1320

tcattccttc agatttggct tgacaaaggc aggaggtaca aaagaagggc tggtattgtt     1380

ctcacactgg tctgctgtcg ctctcagttc tcgataggtc agagcagagg tggaaaaaca     1440

gcatgtacgg attttcagtt acttaatcaa aactcaaatg tgagtgtttt tatcttttta     1500

cctttcatac actagccttg gcctctttcc tcagccttaa gaaccatctg ccaaaaatta     1560

ctgatcctcg catgatggca gccatagtgc atagctacta aaatcagtga ccttgaacat     1620

atcttagatg gggagcctcg ggaaaaggta gaggagtcac gttaccattt acatgtttta     1680

aagaaagaag tgtggggatt ttcactgaaa cgtctaggaa atctagaagt agtcctgaag     1740

gacagaaact aaactcttac catatgtttg gtaagactcc agactccagc taacagtccc     1800

tatggaaaga tggcatcaaa aaagatagat ctatatatat atataaatat atattctatt     1860

acattttcag tgagtaattt tggattttgc aaggtgcatt tttactattg ttacattatg     1920

tggaaaactt atgctgattt atttaagggg gaaaaagtgt caactctttg ttatttgaaa     1980

acatgtttat ttttcttgtc tttattttaa cctttgatag aaccattgca atatgggggc     2040

cttttgggaa cggactggta tgtaaaagaa aatccattat cgagcagcat tttatttacc     2100

cctcccctat ccctaggcac ttaaccaaga caaaaagcca caatgaacat ccctttttca     2160

atgaatttta taatctgcag ctctattccg agcccttagc acccattccg accatagtat     2220

aatcatatca aagggtgaga atcatttagc atgttgttga aaggtttttt ttcagttgtt     2280

ctttttagaa aaaaagaaaa acaaaaacaa aaacaaaaaa aaaaaatcac accattgctc     2340

acagaattgg catctcattt ttgggacctc ccatctttct gttttgaaaa gtgtacagta     2400

gtgcagtgtt cctgatgtaa ctttatggct tacaatgttg acatgtctca ggttcatgtg     2460

ttgcgattgg tgttttccgt ctcaggtaga ttgcaaagtg taggccccac acattggaaa     2520

aaataataat aaaacaaagc aaaaacagga aattatggat tttagttgta tattggttta     2580

tgtatttttt cttaagtata cagtgcactg tttgaaatgt attgttgagt attactttgt     2640

acaggttgat cacttttttt agagtgaaga aagaacaaac ttgttttttg tgttttttaa     2700

aggaatataa aataatgaag gatgtataat tgatgccaaa taagcttgtt ctttagtcac     2760

accgacgtct tatttttccc tttaggccag ttctgttttt aaggtgtaca tggacaatgt     2820

tacagtgtaa gaaactccat atccatatgt tcccattcgc attttgtatt ggttcatgta     2880

taccattttt acaaaaaaaa aaagaaaaaa aagaagtact ataaaatatc tgtcttctta     2940

ataaaaaaaa attaatgtta caaagtga                                        2968


<210>  44
<211>  4310
<212>  DNA
<213>  Homo sapiens

<400>  44
ggttgggctc gcggcgctgt gattggtctg cccggactcc gcctccagcg catgtcatta       60

gcatctcatt agctgtccgc tcgggctccg gaggcagcca acgccgccag tctgaggcag      120

gtgcccgaca tggcgagtgt agtgctgccg agcggatccc agtgtgcggc ggcagcggcg      180

gcggcggcgc ctcccgggct ccggctccgg cttctgctgt tgctcttctc cgccgcggca      240

ctgatcccca caggtgatgg gcagaatctg tttacgaaag acgtgacagt gatcgaggga      300

gaggttgcga ccatcagttg ccaagtcaat aagagtgacg actctgtgat tcagctactg      360

aatcccaaca ggcagaccat ttatttcagg gacttcaggc ctttgaagga cagcaggttt      420

cagttgctga atttttctag cagtgaactc aaagtatcat tgacaaacgt ctcaatttct      480

gatgaaggaa gatacttttg ccagctctat accgatcccc cacaggaaag ttacaccacc      540

atcacagtcc tggtcccacc acgtaatctg atgatcgata tccagaaaga cactgcggtg      600

gaaggtgagg agattgaagt caactgcact gctatggcca gcaagccagc cacgactatc      660

aggtggttca aagggaacac agagctaaaa ggcaaatcgg aggtggaaga gtggtcagac      720

atgtacactg tgaccagtca gctgatgctg aaggtgcaca aggaggacga tggggtccca      780

gtgatctgcc aggtggagca ccctgcggtc actggaaacc tgcagaccca gcggtatcta      840

gaagtacagt ataagcctca agtgcacatt cagatgactt atcctctaca aggcttaacc      900

cgggaagggg acgcgcttga gttaacatgt gaagccatcg ggaagcccca gcctgtgatg      960

gtaacttggg tgagagtcga tgatgaaatg cctcaacacg ccgtactgtc tgggcccaac     1020

ctgttcatca ataacctaaa caaaacagat aatggtacat accgctgtga agcttcaaac     1080

atagtgggga aagctcactc ggattatatg ctgtatgtat acgacacaac ggcgacgaca     1140

gaaccagcag ttcacggcct tactcagttg cccaattccg cagaagaact ggacagtgag     1200

gacctctcag attcccgagc aggtgaagaa ggctcgatca gggcagtgga tcatgccgtg     1260

atcggtggcg tcgtggcggt ggtggtgttc gccatgctgt gcttgctcat cattctgggg     1320

cgctattttg ccagacataa aggtacatac ttcactcatg aagccaaagg agccgatgac     1380

gcagcagacg cagacacagc tataatcaat gcagaaggag gacagaacaa ctccgaagaa     1440

aagaaagagt acttcatcta gatcagcctt tttgtttcaa tgaggtgtcc aactggccct     1500

atttagatga taaagagaca gtgatattgg aacttgcgag aaattcgtgt gtttttttat     1560

gaatgggtgg aaaggtgtga gactgggaag gcttgggatt tgctgtgtaa aaaaaaaaaa     1620

aatgttcttt ggaaagtaca ctctgctgtt tgacacctct tttttcgttt gtttgtttgt     1680

ttaattttta tttcttccta ccaagtcaaa cttggatact tggatttagt ttcagtagat     1740

tgcagaaaat tctgtgcctt gttttttgtt tgtttgttgc gttcctttct tttccccctt     1800

tgtgcacatt tatttcctcc ctctacccca atttcggatt ttttccaaaa tctcccattt     1860

tggaatttgc ctgctgggat tccttagact cttttccttc ccttttctgt tctagttttt     1920

tacttttgtt tatttttatg gtaactgctt tctgttccaa attcagtttc ataaaaggag     1980

aaccagcaca gcttagattt catagttcag aatttagtgt atccataatg cattcttctc     2040

tgttgtcgta aagatttggg tgaacaaaca atgaaaactc tttgctgctg cccatgtttc     2100

aaatacttag agcagtgaag actagaaaat tagactgtga ttcagaaaat gttctgtttg     2160

ctgtggaact acattactgt acagggttat ctgcaagtga ggtgtgtcac aatgagattg     2220

aatttcactg tctttaattc tgtatctgta gacggctcag tatagatacc ctacgctgtc     2280

cagaaaggtt tggggcagaa aggactcctc ctttttccat gccctaaaca gacctgacag     2340

gtgaggtctg ttccttttat ataagtggac aaattttgag ttgccacagg aggggaagta     2400

gggagggggg aaatacagtt ctgctctggt tgtttctgtt ccaaatgatt ccatccacct     2460

ttcccaatcg gccttacttc tcactaattt gtaggaaaaa gcaagttcgt ctgttgtgcg     2520

aatgactgaa tgggacagag ttgatttttt tttttttttc ctttgtgctt agttaggaag     2580

gcagtaggat gtggcctgca tgtactgtat attacagata tttgtcatgc tgggatttcc     2640

aactcgaatc tgtgtgaaac tttcattcct tcagatttgg cttgacaaag gcaggaggta     2700

caaaagaagg gctggtattg ttctcacact ggtctgctgt cgctctcagt tctcgatagg     2760

tcagagcaga ggtggaaaaa cagcatgtac ggattttcag ttacttaatc aaaactcaaa     2820

tgtgagtgtt tttatctttt tacctttcat acactagcct tggcctcttt cctcagcctt     2880

aagaaccatc tgccaaaaat tactgatcct cgcatgatgg cagccatagt gcatagctac     2940

taaaatcagt gaccttgaac atatcttaga tggggagcct cgggaaaagg tagaggagtc     3000

acgttaccat ttacatgttt taaagaaaga agtgtgggga ttttcactga aacgtctagg     3060

aaatctagaa gtagtcctga aggacagaaa ctaaactctt accatatgtt tggtaagact     3120

ccagactcca gctaacagtc cctatggaaa gatggcatca aaaaagatag atctatatat     3180

atatataaat atatattcta ttacattttc agtgagtaat tttggatttt gcaaggtgca     3240

tttttactat tgttacatta tgtggaaaac ttatgctgat ttatttaagg gggaaaaagt     3300

gtcaactctt tgttatttga aaacatgttt atttttcttg tctttatttt aacctttgat     3360

agaaccattg caatatgggg gccttttggg aacggactgg tatgtaaaag aaaatccatt     3420

atcgagcagc attttattta cccctcccct atccctaggc acttaaccaa gacaaaaagc     3480

cacaatgaac atcccttttt caatgaattt tataatctgc agctctattc cgagccctta     3540

gcacccattc cgaccatagt ataatcatat caaagggtga gaatcattta gcatgttgtt     3600

gaaaggtttt ttttcagttg ttctttttag aaaaaaagaa aaacaaaaac aaaaacaaaa     3660

aaaaaaaatc acaccattgc tcacagaatt ggcatctcat ttttgggacc tcccatcttt     3720

ctgttttgaa aagtgtacag tagtgcagtg ttcctgatgt aactttatgg cttacaatgt     3780

tgacatgtct caggttcatg tgttgcgatt ggtgttttcc gtctcaggta gattgcaaag     3840

tgtaggcccc acacattgga aaaaataata ataaaacaaa gcaaaaacag gaaattatgg     3900

attttagttg tatattggtt tatgtatttt ttcttaagta tacagtgcac tgtttgaaat     3960

gtattgttga gtattacttt gtacaggttg atcacttttt ttagagtgaa gaaagaacaa     4020

acttgttttt tgtgtttttt aaaggaatat aaaataatga aggatgtata attgatgcca     4080

aataagcttg ttctttagtc acaccgacgt cttatttttc cctttaggcc agttctgttt     4140

ttaaggtgta catggacaat gttacagtgt aagaaactcc atatccatat gttcccattc     4200

gcattttgta ttggttcatg tataccattt ttacaaaaaa aaaaagaaaa aaaagaagta     4260

ctataaaata tctgtcttct taataaaaaa aaattaatgt tacaaagtga                4310


<210>  45
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr 
        35                  40      


<210>  46
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Gly Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu 
1               5                   10                  15      


Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile 
            20                  25                  30          


Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg 
        35                  40                  45              


<210>  47
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu 
1               5                   10                  15      


Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe 
            20                  25                  30          


Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr 
        35                  40                  45              


Val Leu 
    50  


<210>  48
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu 
1               5                   10                  15      


Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala 
            20                  25                  30          


Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys 
        35                  40                  45  


<210>  49
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  49

Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln 
1               5                   10                  15      


Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys 
            20                  25                  30          


Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr 
        35                  40                  45              


Leu Glu Val Gln 
    50          


<210>  50
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  50

Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu Thr 
1               5                   10                  15      


Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys Pro 
            20                  25                  30          


<210>  51
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  51

Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro Gln His 
1               5                   10                  15      


Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn Lys Thr 
            20                  25                  30          


Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly Lys Ala 
        35                  40                  45              


His Ser Asp Tyr Met Leu Tyr Val Tyr 
    50                  55          


<210>  52
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  52

Thr Thr Ala Thr Thr Glu Pro Ala Val His 
1               5                   10  


<210>  53
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  53

Leu Thr Gln Leu Pro Asn Ser Ala Glu Glu Leu Asp Ser Glu Asp Leu 
1               5                   10                  15      


Ser 
    


<210>  54
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Arg Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp His Ala Val 
1               5                   10                  15      


Ile Gly Gly Val Val Ala Val Val Val Phe Ala Met Leu Cys Leu Leu 
            20                  25                  30          


Ile Ile Leu Gly Arg Tyr Phe Ala Arg His Lys 
        35                  40              


<210>  55
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  55

Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp Ala Ala Asp Ala 
1               5                   10                  15      


Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn Asn Ser Glu Glu 
            20                  25                  30          


Lys Lys Glu Tyr Phe Ile 
        35              


<210>  56
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Thr Thr Ala Thr 
                325                 330                 335     


Thr Glu Pro Ala Val His Gly Leu Thr Gln Leu Pro Asn Ser Ala Glu 
            340                 345                 350         


Glu Leu Asp Ser Glu Asp Leu Ser Asp Ser Arg Ala Gly Glu Glu Gly 
        355                 360                 365             


Ser Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val 
    370                 375                 380                 


Val Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe 
385                 390                 395                 400 


Ala Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp 
                405                 410                 415     


Asp Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln 
            420                 425                 430         


Asn Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440             


<210>  57
<211>  1123
<212>  DNA
<213>  Homo sapiens

<400>  57
ggttgggctc gcggcgctgt gattggtctg cccggactcc gcctccagcg catgtcatta       60

gcatctcatt agctgtccgc tcgggctccg gaggcagcca acgccgccag tctgaggcag      120

gtgcccgaca tggcgagtgt agtgctgccg agcggatccc agtgtgcggc ggcagcggcg      180

gcggcggcgc ctcccgggct ccggctccgg cttctgctgt tgctcttctc cgccgcggca      240

ctgatcccca caggtgatgg gcagaatctg tttacgaaag acgtgacagt gatcgaggga      300

gaggttgcga ccatcagttg ccaagtcaat aagagtgacg actctgtgat tcagctactg      360

aatcccaaca ggcagaccat ttatttcagg gacttcaggc ctttgaagga cagcaggttt      420

cagttgctga atttttctag cagtgaactc aaagtatcat tgacaaacgt ctcaatttct      480

gatgaaggaa gatacttttg ccagctctat accgatcccc cacaggaaag ttacaccacc      540

atcacagtcc tggtcccacc acgtaatctg atgatcgata tccagaaaga cactgcggtg      600

gaaggtgagg agattgaagt caactgcact gctatggcca gcaagccagc cacgactatc      660

aggtggttca aagggaacac agagctaaaa ggcaaatcgg aggtggaaga gtggtcagac      720

atgtacactg tgaccagtca gctgatgctg aaggtgcaca aggaggacga tggggtccca      780

gtgatctgcc aggtggagca ccctgcggtc actggaaacc tgcagaccca gcggtatcta      840

gaagtacagt ataagcctca agtgcacatt cagatgactt atcctctaca aggcttaacc      900

cgggaagggg acgcgcttga gttaacatgt gaagccatcg ggaagcccca gcctgtgatg      960

gtaacttggg tgagagtcga tgatgaaatg cctcaacacg ccgtactgtc tgggcccaac     1020

ctgttcatca ataacctaaa caaaacagat aatggtacat accgctgtga agcttcaaac     1080

atagtgggga aagctcactc ggattatatg ctgtatgtat acg                       1123


<210>  58
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr 
                325                 330     


<210>  59
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  59
000

<210>  60
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  60
000

<210>  61
<211>  200
<212>  DNA
<213>  Homo sapiens

<400>  61
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct       60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt      120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc      180

gctgagcctg gcgcagatcg                                                  200


<210>  62
<211>  166
<212>  DNA
<213>  Homo sapiens

<400>  62
atttgaatat aacctgccgc tttgcaggtg tattccacgt ggagaaaaat ggtcgctaca       60

gcatctctcg gacggaggcc gctgacctct gcaaggcttt caatagcacc ttgcccacaa      120

tggcccagat ggagaaagct ctgagcatcg gatttgagac ctgcag                     166


<210>  63
<211>  134
<212>  DNA
<213>  Homo sapiens

<400>  63
gtatgggttc atagaagggc acgtggtgat tccccggatc caccccaact ccatctgtgc       60

agcaaacaac acaggggtgt acatcctcac atccaacacc tcccagtatg acacatattg      120

cttcaatgct tcag                                                        134


<210>  64
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  64
ctccacctga agaagattgt acatcagtca cagacctgcc caatgccttt gatggaccaa       60

ttaccataa                                                               69


<210>  65
<211>  231
<212>  DNA
<213>  Homo sapiens

<400>  65
ctattgttaa ccgtgatggc acccgctatg tccagaaagg agaatacaga acgaatcctg       60

aagacatcta ccccagcaac cctactgatg atgacgtgag cagcggctcc tccagtgaaa      120

ggagcagcac ttcaggaggt tacatctttt acaccttttc tactgtacac cccatcccag      180

acgaagacag tccctggatc accgacagca cagacagaat ccctgctacc a               231


<210>  66
<211>  129
<212>  DNA
<213>  Homo sapiens

<400>  66
ctttgatgag cactagtgct acagcaactg agacagcaac caagaggcaa gaaacctggg       60

attggttttc atggttgttt ctaccatcag agtcaaagaa tcatcttcac acaacaacac      120

aaatggctg                                                              129


<210>  67
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  67
gtacgtcttc aaataccatc tcagcaggct gggagccaaa tgaagaaaat gaagatgaaa       60

gagacagaca cctcagtttt tctggatcag gcattgatga tgatgaagat tttatctcca      120

gcacca                                                                 126


<210>  68
<211>  114
<212>  DNA
<213>  Homo sapiens

<400>  68
tttcaaccac accacgggct tttgaccaca caaaacagaa ccaggactgg acccagtgga       60

acccaagcca ttcaaatccg gaagtgctac ttcagacaac cacaaggatg actg            114


<210>  69
<211>  117
<212>  DNA
<213>  Homo sapiens

<400>  69
atgtagacag aaatggcacc actgcttatg aaggaaactg gaacccagaa gcacaccctc       60

ccctcattca ccatgagcat catgaggaag aagagacccc acattctaca agcacaa         117


<210>  70
<211>  129
<212>  DNA
<213>  Homo sapiens

<400>  70
tccaggcaac tcctagtagt acaacggaag aaacagctac ccagaaggaa cagtggtttg       60

gcaacagatg gcatgaggga tatcgccaaa cacccaaaga agactcccat tcgacaacag      120

ggacagctg                                                              129


<210>  71
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  71
cagcctcagc tcataccagc catccaatgc aaggaaggac aacaccaagc ccagaggaca       60

gttcctggac tgatttcttc aacccaatct cacaccccat gggacgaggt catcaagcag      120

gaagaaggat gg                                                          132


<210>  72
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  72
atatggactc cagtcatagt ataacgcttc agcctactgc aaatccaaac acaggtttgg       60

tggaagattt ggacaggaca ggacctcttt caatgacaac gc                         102


<210>  73
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  73
agcagagtaa ttctcagagc ttctctacat cacatgaagg cttggaagaa gataaagacc       60

atccaacaac ttctactctg acatcaagca                                        90


<210>  74
<211>  204
<212>  DNA
<213>  Homo sapiens

<400>  74
ataggaatga tgtcacaggt ggaagaagag acccaaatca ttctgaaggc tcaactactt       60

tactggaagg ttatacctct cattacccac acacgaagga aagcaggacc ttcatcccag      120

tgacctcagc taagactggg tcctttggag ttactgcagt tactgttgga gattccaact      180

ctaatgtcaa tcgttcctta tcag                                             204


<210>  75
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  75
gagaccaaga cacattccac cccagtgggg ggtcccatac cactcatgga tctgaatcag       60

atg                                                                     63


<210>  76
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  76
gacactcaca tgggagtcaa gaaggtggag caaacacaac ctctggtcct ataaggacac       60

cccaaattcc ag                                                           72


<210>  77
<211>  79
<212>  DNA
<213>  Homo sapiens

<400>  77
aatggctgat catcttggca tccctcttgg ccttggcttt gattcttgca gtttgcattg       60

cagtcaacag tcgaagaag                                                    79


<210>  78
<211>  3274
<212>  DNA
<213>  Homo sapiens

<400>  78
gtgtgggcag aagaaaaagc tagtgatcaa cagtggcaat ggagctgtgg aggacagaaa       60

gccaagtgga ctcaacggag aggccagcaa gtctcaggaa atggtgcatt tggtgaacaa      120

ggagtcgtca gaaactccag accagtttat gacagctgat gagacaagga acctgcagaa      180

tgtggacatg aagattgggg tgtaacacct acaccattat cttggaaaga aacaaccgtt      240

ggaaacataa ccattacagg gagctgggac acttaacaga tgcaatgtgc tactgattgt      300

ttcattgcga atctttttta gcataaaatt ttctactctt tttgtttttt gtgttttgtt      360

ctttaaagtc aggtccaatt tgtaaaaaca gcattgcttt ctgaaattag ggcccaatta      420

ataatcagca agaatttgat cgttccagtt cccacttgga ggcctttcat ccctcgggtg      480

tgctatggat ggcttctaac aaaaactaca catatgtatt cctgatcgcc aacctttccc      540

ccaccagcta aggacatttc ccagggttaa tagggcctgg tccctgggag gaaatttgaa      600

tgggtccatt ttgcccttcc atagcctaat ccctgggcat tgctttccac tgaggttggg      660

ggttggggtg tactagttac acatcttcaa cagaccccct ctagaaattt ttcagatgct      720

tctgggagac acccaaaggg tgaagctatt tatctgtagt aaactattta tctgtgtttt      780

tgaaatatta aaccctggat cagtcctttg atcagtataa ttttttaaag ttactttgtc      840

agaggcacaa aagggtttaa actgattcat aataaatatc tgtacttctt cgatcttcac      900

cttttgtgct gtgattcttc agtttctaaa ccagcactgt ctgggtccct acaatgtatc      960

aggaagagct gagaatggta aggagactct tctaagtctt catctcagag accctgagtt     1020

cccactcaga cccactcagc caaatctcat ggaagaccaa ggagggcagc actgtttttg     1080

ttttttgttt tttgtttttt ttttttgaca ctgtccaaag gttttccatc ctgtcctgga     1140

atcagagttg gaagctgagg agcttcagcc tcttttatgg tttaatggcc acctgttctc     1200

tcctgtgaaa ggctttgcaa agtcacatta agtttgcatg acctgttatc cctggggccc     1260

tatttcatag aggctggccc tattagtgat ttccaaaaac aatatggaag tgccttttga     1320

tgtcttacaa taagagaaga agccaatgga aatgaaagag attggcaaag gggaaggatg     1380

atgccatgta gatcctgttt gacattttta tggctgtatt tgtaaactta aacacaccag     1440

tgtctgttct tgatgcagtt gctatttagg atgagttaag tgcctgggga gtccctcaaa     1500

aggttaaagg gattcccatc attggaatct tatcaccaga taggcaagtt tatgaccaaa     1560

caagagagta ctggctttat cctctaacct catattttct cccacttggc aagtcctttg     1620

tggcatttat tcatcagtca gggtgtccga ttggtcctag aacttccaaa ggctgcttgt     1680

catagaagcc attgcatcta taaagcaacg gctcctgtta aatggtatct cctttctgag     1740

gctcctacta aaagtcattt gttacctaaa cttatgtgct taacaggcaa tgcttctcag     1800

accacaaagc agaaagaaga agaaaagctc ctgactaaat cagggctggg cttagacaga     1860

gttgatctgt agaatatctt taaaggagag atgtcaactt tctgcactat tcccagcctc     1920

tgctcctccc tgtctaccct ctcccctccc tctctccctc cacttcaccc cacaatcttg     1980

aaaaacttcc tttctcttct gtgaacatca ttggccagat ccattttcag tggtctggat     2040

ttctttttat tttcttttca acttgaaaga aactggacat taggccacta tgtgttgtta     2100

ctgccactag tgttcaagtg cctcttgttt tcccagagat ttcctgggtc tgccagaggc     2160

ccagacaggc tcactcaagc tctttaactg aaaagcaaca agccactcca ggacaaggtt     2220

caaaatggtt acaacagcct ctacctgtcg ccccagggag aaaggggtag tgatacaagt     2280

ctcatagcca gagatggttt tccactcctt ctagatattc ccaaaaagag gctgagacag     2340

gaggttattt tcaattttat tttggaatta aatacttttt tccctttatt actgttgtag     2400

tccctcactt ggatatacct ctgttttcac gatagaaata agggaggtct agagcttcta     2460

ttccttggcc attgtcaacg gagagctggc caagtcttca caaacccttg caacattgcc     2520

tgaagtttat ggaataagat gtattctcac tcccttgatc tcaagggcgt aactctggaa     2580

gcacagcttg actacacgtc atttttacca atgattttca ggtgacctgg gctaagtcat     2640

ttaaactggg tctttataaa agtaaaaggc caacatttaa ttattttgca aagcaaccta     2700

agagctaaag atgtaatttt tcttgcaatt gtaaatcttt tgtgtctcct gaagacttcc     2760

cttaaaatta gctctgagtg aaaaatcaaa agagacaaaa gacatcttcg aatccatatt     2820

tcaagcctgg tagaattggc ttttctagca gaacctttcc aaaagtttta tattgagatt     2880

cataacaaca ccaagaattg attttgtagc caacattcat tcaatactgt tatatcagag     2940

gagtaggaga gaggaaacat ttgacttatc tggaaaagca aaatgtactt aagaataaga     3000

ataacatggt ccattcacct ttatgttata gatatgtctt tgtgtaaatc atttgttttg     3060

agttttcaaa gaatagccca ttgttcattc ttgtgctgta caatgaccac tgttattgtt     3120

actttgactt ttcagagcac acccttcctc tggtttttgt atatttattg atggatcaat     3180

aataatgagg aaagcatgat atgtatattg ctgagttgaa agcacttatt ggaaaatatt     3240

aaaaggctaa cattaaaaga ctaaaggaaa caga                                 3274


<210>  79
<211>  5431
<212>  DNA
<213>  Homo sapiens

<400>  79
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct       60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt      120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc      180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt      240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt      300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac      360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat      420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac      480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc      540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt      600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga      660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta      720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac      780

agacagaatc cctgctacca ctttgatgag cactagtgct acagcaactg agacagcaac      840

caagaggcaa gaaacctggg attggttttc atggttgttt ctaccatcag agtcaaagaa      900

tcatcttcac acaacaacac aaatggctgg tacgtcttca aataccatct cagcaggctg      960

ggagccaaat gaagaaaatg aagatgaaag agacagacac ctcagttttt ctggatcagg     1020

cattgatgat gatgaagatt ttatctccag caccatttca accacaccac gggcttttga     1080

ccacacaaaa cagaaccagg actggaccca gtggaaccca agccattcaa atccggaagt     1140

gctacttcag acaaccacaa ggatgactga tgtagacaga aatggcacca ctgcttatga     1200

aggaaactgg aacccagaag cacaccctcc cctcattcac catgagcatc atgaggaaga     1260

agagacccca cattctacaa gcacaatcca ggcaactcct agtagtacaa cggaagaaac     1320

agctacccag aaggaacagt ggtttggcaa cagatggcat gagggatatc gccaaacacc     1380

caaagaagac tcccattcga caacagggac agctgcagcc tcagctcata ccagccatcc     1440

aatgcaagga aggacaacac caagcccaga ggacagttcc tggactgatt tcttcaaccc     1500

aatctcacac cccatgggac gaggtcatca agcaggaaga aggatggata tggactccag     1560

tcatagtata acgcttcagc ctactgcaaa tccaaacaca ggtttggtgg aagatttgga     1620

caggacagga cctctttcaa tgacaacgca gcagagtaat tctcagagct tctctacatc     1680

acatgaaggc ttggaagaag ataaagacca tccaacaact tctactctga catcaagcaa     1740

taggaatgat gtcacaggtg gaagaagaga cccaaatcat tctgaaggct caactacttt     1800

actggaaggt tatacctctc attacccaca cacgaaggaa agcaggacct tcatcccagt     1860

gacctcagct aagactgggt cctttggagt tactgcagtt actgttggag attccaactc     1920

taatgtcaat cgttccttat caggagacca agacacattc caccccagtg gggggtccca     1980

taccactcat ggatctgaat cagatggaca ctcacatggg agtcaagaag gtggagcaaa     2040

cacaacctct ggtcctataa ggacacccca aattccagaa tggctgatca tcttggcatc     2100

cctcttggcc ttggctttga ttcttgcagt ttgcattgca gtcaacagtc gaagaaggtg     2160

tgggcagaag aaaaagctag tgatcaacag tggcaatgga gctgtggagg acagaaagcc     2220

aagtggactc aacggagagg ccagcaagtc tcaggaaatg gtgcatttgg tgaacaagga     2280

gtcgtcagaa actccagacc agtttatgac agctgatgag acaaggaacc tgcagaatgt     2340

ggacatgaag attggggtgt aacacctaca ccattatctt ggaaagaaac aaccgttgga     2400

aacataacca ttacagggag ctgggacact taacagatgc aatgtgctac tgattgtttc     2460

attgcgaatc ttttttagca taaaattttc tactcttttt gttttttgtg ttttgttctt     2520

taaagtcagg tccaatttgt aaaaacagca ttgctttctg aaattagggc ccaattaata     2580

atcagcaaga atttgatcgt tccagttccc acttggaggc ctttcatccc tcgggtgtgc     2640

tatggatggc ttctaacaaa aactacacat atgtattcct gatcgccaac ctttccccca     2700

ccagctaagg acatttccca gggttaatag ggcctggtcc ctgggaggaa atttgaatgg     2760

gtccattttg cccttccata gcctaatccc tgggcattgc tttccactga ggttgggggt     2820

tggggtgtac tagttacaca tcttcaacag accccctcta gaaatttttc agatgcttct     2880

gggagacacc caaagggtga agctatttat ctgtagtaaa ctatttatct gtgtttttga     2940

aatattaaac cctggatcag tcctttgatc agtataattt tttaaagtta ctttgtcaga     3000

ggcacaaaag ggtttaaact gattcataat aaatatctgt acttcttcga tcttcacctt     3060

ttgtgctgtg attcttcagt ttctaaacca gcactgtctg ggtccctaca atgtatcagg     3120

aagagctgag aatggtaagg agactcttct aagtcttcat ctcagagacc ctgagttccc     3180

actcagaccc actcagccaa atctcatgga agaccaagga gggcagcact gtttttgttt     3240

tttgtttttt gttttttttt tttgacactg tccaaaggtt ttccatcctg tcctggaatc     3300

agagttggaa gctgaggagc ttcagcctct tttatggttt aatggccacc tgttctctcc     3360

tgtgaaaggc tttgcaaagt cacattaagt ttgcatgacc tgttatccct ggggccctat     3420

ttcatagagg ctggccctat tagtgatttc caaaaacaat atggaagtgc cttttgatgt     3480

cttacaataa gagaagaagc caatggaaat gaaagagatt ggcaaagggg aaggatgatg     3540

ccatgtagat cctgtttgac atttttatgg ctgtatttgt aaacttaaac acaccagtgt     3600

ctgttcttga tgcagttgct atttaggatg agttaagtgc ctggggagtc cctcaaaagg     3660

ttaaagggat tcccatcatt ggaatcttat caccagatag gcaagtttat gaccaaacaa     3720

gagagtactg gctttatcct ctaacctcat attttctccc acttggcaag tcctttgtgg     3780

catttattca tcagtcaggg tgtccgattg gtcctagaac ttccaaaggc tgcttgtcat     3840

agaagccatt gcatctataa agcaacggct cctgttaaat ggtatctcct ttctgaggct     3900

cctactaaaa gtcatttgtt acctaaactt atgtgcttaa caggcaatgc ttctcagacc     3960

acaaagcaga aagaagaaga aaagctcctg actaaatcag ggctgggctt agacagagtt     4020

gatctgtaga atatctttaa aggagagatg tcaactttct gcactattcc cagcctctgc     4080

tcctccctgt ctaccctctc ccctccctct ctccctccac ttcaccccac aatcttgaaa     4140

aacttccttt ctcttctgtg aacatcattg gccagatcca ttttcagtgg tctggatttc     4200

tttttatttt cttttcaact tgaaagaaac tggacattag gccactatgt gttgttactg     4260

ccactagtgt tcaagtgcct cttgttttcc cagagatttc ctgggtctgc cagaggccca     4320

gacaggctca ctcaagctct ttaactgaaa agcaacaagc cactccagga caaggttcaa     4380

aatggttaca acagcctcta cctgtcgccc cagggagaaa ggggtagtga tacaagtctc     4440

atagccagag atggttttcc actccttcta gatattccca aaaagaggct gagacaggag     4500

gttattttca attttatttt ggaattaaat acttttttcc ctttattact gttgtagtcc     4560

ctcacttgga tatacctctg ttttcacgat agaaataagg gaggtctaga gcttctattc     4620

cttggccatt gtcaacggag agctggccaa gtcttcacaa acccttgcaa cattgcctga     4680

agtttatgga ataagatgta ttctcactcc cttgatctca agggcgtaac tctggaagca     4740

cagcttgact acacgtcatt tttaccaatg attttcaggt gacctgggct aagtcattta     4800

aactgggtct ttataaaagt aaaaggccaa catttaatta ttttgcaaag caacctaaga     4860

gctaaagatg taatttttct tgcaattgta aatcttttgt gtctcctgaa gacttccctt     4920

aaaattagct ctgagtgaaa aatcaaaaga gacaaaagac atcttcgaat ccatatttca     4980

agcctggtag aattggcttt tctagcagaa cctttccaaa agttttatat tgagattcat     5040

aacaacacca agaattgatt ttgtagccaa cattcattca atactgttat atcagaggag     5100

taggagagag gaaacatttg acttatctgg aaaagcaaaa tgtacttaag aataagaata     5160

acatggtcca ttcaccttta tgttatagat atgtctttgt gtaaatcatt tgttttgagt     5220

tttcaaagaa tagcccattg ttcattcttg tgctgtacaa tgaccactgt tattgttact     5280

ttgacttttc agagcacacc cttcctctgg tttttgtata tttattgatg gatcaataat     5340

aatgaggaaa gcatgatatg tatattgctg agttgaaagc acttattgga aaatattaaa     5400

aggctaacat taaaagacta aaggaaacag a                                    5431


<210>  80
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile 
            20          


<210>  81
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  81

Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu Lys Asn 
1               5                   10                  15      


Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys Lys Ala 
            20                  25                  30          


Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala Leu Ser 
        35                  40                  45              


Ile Gly Phe Glu Thr Cys 
    50                  


<210>  82
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  82

Tyr Gly Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn 
1               5                   10                  15      


Ser Ile Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn 
            20                  25                  30          


Thr Ser Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser 
        35                  40                  


<210>  83
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  83

Pro Pro Glu Glu Asp Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe 
1               5                   10                  15      


Asp Gly Pro Ile Thr Ile 
            20          


<210>  84
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  84

Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg 
1               5                   10                  15      


Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val 
            20                  25                  30          


Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile 
        35                  40                  45              


Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro 
    50                  55                  60                  


Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr 
65                  70                  75      


<210>  85
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  85

Leu Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln 
1               5                   10                  15      


Glu Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys 
            20                  25                  30          


Asn His Leu His Thr Thr Thr Gln Met Ala 
        35                  40          


<210>  86
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  86

Thr Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn 
1               5                   10                  15      


Glu Asp Glu Arg Asp Arg His Leu Ser Phe Ser Gly Ser Gly Ile Asp 
            20                  25                  30          


Asp Asp Glu Asp Phe Ile Ser Ser Thr 
        35                  40      


<210>  87
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  87

Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp 
1               5                   10                  15      


Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr 
            20                  25                  30          


Thr Thr Arg Met Thr 
        35          


<210>  88
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  88

Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu 
1               5                   10                  15      


Ala His Pro Pro Leu Ile His His Glu His His Glu Glu Glu Glu Thr 
            20                  25                  30          


Pro His Ser Thr Ser Thr 
        35              


<210>  89
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  89

Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys Glu 
1               5                   10                  15      


Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro Lys 
            20                  25                  30          


Glu Asp Ser His Ser Thr Thr Gly Thr Ala 
        35                  40          


<210>  90
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  90

Ala Ser Ala His Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser 
1               5                   10                  15      


Pro Glu Asp Ser Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro 
            20                  25                  30          


Met Gly Arg Gly His Gln Ala Gly Arg Arg Met 
        35                  40              


<210>  91
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala Asn Pro Asn 
1               5                   10                  15      


Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu Ser Met Thr 
            20                  25                  30          


Thr 
    


<210>  92
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His Glu Gly Leu Glu Glu 
1               5                   10                  15      


Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr Ser Ser 
            20                  25                  


<210>  93
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  93

Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His Ser Glu Gly 
1               5                   10                  15      


Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro His Thr Lys 
            20                  25                  30          


Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr Gly Ser Phe 
        35                  40                  45              


Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn Val Asn Arg 
    50                  55                  60                  


Ser Leu Ser 
65          


<210>  94
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  94

Asp Gln Asp Thr Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly 
1               5                   10                  15      


Ser Glu Ser Asp 
            20  


<210>  95
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  95

His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro 
1               5                   10                  15      


Ile Arg Thr Pro Gln Ile Pro 
            20              


<210>  96
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  96

Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
1               5                   10                  15      


Val Cys Ile Ala Val Asn Ser Arg Arg 
            20                  25  


<210>  97
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  97

Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val 
1               5                   10                  15      


Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln 
            20                  25                  30          


Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln 
        35                  40                  45              


Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys 
    50                  55                  60                  


Ile Gly Val 
65          


<210>  98
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  99
<211>  800
<212>  DNA
<213>  Homo sapiens

<400>  99
ctcattgccc agcggacccc agcctctgcc aggttcggtc cgccatcctc gtcccgtcct       60

ccgccggccc ctgccccgcg cccagggatc ctccagctcc tttcgcccgc gccctccgtt      120

cgctccggac accatggaca agttttggtg gcacgcagcc tggggactct gcctcgtgcc      180

gctgagcctg gcgcagatcg atttgaatat aacctgccgc tttgcaggtg tattccacgt      240

ggagaaaaat ggtcgctaca gcatctctcg gacggaggcc gctgacctct gcaaggcttt      300

caatagcacc ttgcccacaa tggcccagat ggagaaagct ctgagcatcg gatttgagac      360

ctgcaggtat gggttcatag aagggcacgt ggtgattccc cggatccacc ccaactccat      420

ctgtgcagca aacaacacag gggtgtacat cctcacatcc aacacctccc agtatgacac      480

atattgcttc aatgcttcag ctccacctga agaagattgt acatcagtca cagacctgcc      540

caatgccttt gatggaccaa ttaccataac tattgttaac cgtgatggca cccgctatgt      600

ccagaaagga gaatacagaa cgaatcctga agacatctac cccagcaacc ctactgatga      660

tgacgtgagc agcggctcct ccagtgaaag gagcagcact tcaggaggtt acatctttta      720

caccttttct actgtacacc ccatcccaga cgaagacagt ccctggatca ccgacagcac      780

agacagaatc cctgctacca                                                  800


<210>  100
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr 
    210                 215                 220         


<210>  101
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  101
000

<210>  102
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  102
000

<210>  103
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  103
agatgcagta gccgaaactg cgcggaggca cagaggccgg ggagagcgtt ctgggtccga       60

gggtccaggt aggggttgag ccaccatctg accgcaagct gcgtcgtgtc gccggttctg      120

caggcaccat gagccaggac accgaggtgg atatgaagga ggtggagctg aatgagttag      180

agcccgagaa gcagccgatg aacgcggcgt ctggggcggc catgtccctg gcgggagccg      240

agaagaatgg tctggtgaag atcaaggtgg cggaagacga ggcggaggcg gcagccgcgg      300

ctaagttcac gggcctgtcc aaggaggagc tgctgaaggt ggcaggcagc cccggctggg      360

tacgcacccg ctgggcactg ctgctgctct tctggctcgg ctggctcggc atgcttgctg      420

gtgccgtggt cataatcgtg cgagcgccgc gttgtcgcga gctaccggcg cagaagtggt      480

ggcacacggg cgccctctac cgcatcggcg accttcaggc cttccagggc cacggcgcgg      540

gcaacctggc gg                                                          552


<210>  104
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  104
gtctgaaggg gcgtctcgat tacctgagct ctctgaaggt gaagggcctt gtgctgggtc       60

caattcacaa gaaccagaag gatgatgtcg ctcagactga cttgctgcag atcgacccca      120

attttggctc caaggaagat tttgacagtc tcttgcaatc ggctaaaaaa aaga            174


<210>  105
<211>  91
<212>  DNA
<213>  Homo sapiens

<400>  105
gcatccgtgt cattctggac cttactccca actaccgggg tgagaactcg tggttctcca       60

ctcaggttga cactgtggcc accaaggtga a                                      91


<210>  106
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  106
gatgctctgg agttttggct gcaagctggc gtggatgggt tccaggttcg ggacatagag       60

aatctgaag                                                               69


<210>  107
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  107
gatgcatcct cattcttggc tgagtggcaa aatatcacca agggcttcag tgaagacag        59


<210>  108
<211>  181
<212>  DNA
<213>  Homo sapiens

<400>  108
gctcttgatt gcggggacta actcctccga ccttcagcag atcctgagcc tactcgaatc       60

caacaaagac ttgctgttga ctagctcata cctgtctgat tctggttcta ctggggagca      120

tacaaaatcc ctagtcacac agtatttgaa tgccactggc aatcgctggt gcagctggag      180

t                                                                      181


<210>  109
<211>  144
<212>  DNA
<213>  Homo sapiens

<400>  109
ttgtctcagg caaggctcct gacttccttc ttgccggctc aacttctccg actctaccag       60

ctgatgctct tcaccctgcc agggacccct gttttcagct acggggatga gattggcctg      120

gatgcagctg cccttcctgg acag                                             144


<210>  110
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  110
cctatggagg ctccagtcat gctgtgggat gagtccagct tccctgacat cccaggggct       60

gtaagtgcca acatgactgt gaag                                              84


<210>  111
<211>  530
<212>  DNA
<213>  Homo sapiens

<400>  111
ggccagagtg aagaccctgg ctccctcctt tccttgttcc ggcggctgag tgaccagcgg       60

agtaaggagc gctccctact gcatggggac ttccacgcgt tctccgctgg gcctggactc      120

ttctcctata tccgccactg ggaccagaat gagcgttttc tggtagtgct taactttggg      180

gatgtgggcc tctcggctgg actgcaggcc tccgacctgc ctgccagcgc cagcctgcca      240

gccaaggctg acctcctgct cagcacccag ccaggccgtg aggagggctc ccctcttgag      300

ctggaacgcc tgaaactgga gcctcacgaa gggctgctgc tccgcttccc ctacgcggcc      360

tgacttcagc ctgacatgga cccactaccc ttctcctttc cttcccaggc cctttggctt      420

ctgatttttc tcttttttaa aaacaaacaa acaaactgtt gcagattatg agtgaacccc      480

caaatagggt gttttctgcc ttcaaataaa agtcacccct gcatggtgaa                 530


<210>  112
<211>  1884
<212>  DNA
<213>  Homo sapiens

<400>  112
agatgcagta gccgaaactg cgcggaggca cagaggccgg ggagagcgtt ctgggtccga       60

gggtccaggt aggggttgag ccaccatctg accgcaagct gcgtcgtgtc gccggttctg      120

caggcaccat gagccaggac accgaggtgg atatgaagga ggtggagctg aatgagttag      180

agcccgagaa gcagccgatg aacgcggcgt ctggggcggc catgtccctg gcgggagccg      240

agaagaatgg tctggtgaag atcaaggtgg cggaagacga ggcggaggcg gcagccgcgg      300

ctaagttcac gggcctgtcc aaggaggagc tgctgaaggt ggcaggcagc cccggctggg      360

tacgcacccg ctgggcactg ctgctgctct tctggctcgg ctggctcggc atgcttgctg      420

gtgccgtggt cataatcgtg cgagcgccgc gttgtcgcga gctaccggcg cagaagtggt      480

ggcacacggg cgccctctac cgcatcggcg accttcaggc cttccagggc cacggcgcgg      540

gcaacctggc gggtctgaag gggcgtctcg attacctgag ctctctgaag gtgaagggcc      600

ttgtgctggg tccaattcac aagaaccaga aggatgatgt cgctcagact gacttgctgc      660

agatcgaccc caattttggc tccaaggaag attttgacag tctcttgcaa tcggctaaaa      720

aaaagagcat ccgtgtcatt ctggacctta ctcccaacta ccggggtgag aactcgtggt      780

tctccactca ggttgacact gtggccacca aggtgaagat gctctggagt tttggctgca      840

agctggcgtg gatgggttcc aggttcggga catagagaat ctgaaggatg catcctcatt      900

cttggctgag tggcaaaata tcaccaaggg cttcagtgaa gacaggctct tgattgcggg      960

gactaactcc tccgaccttc agcagatcct gagcctactc gaatccaaca aagacttgct     1020

gttgactagc tcatacctgt ctgattctgg ttctactggg gagcatacaa aatccctagt     1080

cacacagtat ttgaatgcca ctggcaatcg ctggtgcagc tggagtttgt ctcaggcaag     1140

gctcctgact tccttcttgc cggctcaact tctccgactc taccagctga tgctcttcac     1200

cctgccaggg acccctgttt tcagctacgg ggatgagatt ggcctggatg cagctgccct     1260

tcctggacag cctatggagg ctccagtcat gctgtgggat gagtccagct tccctgacat     1320

cccaggggct gtaagtgcca acatgactgt gaagggccag agtgaagacc ctggctccct     1380

cctttccttg ttccggcggc tgagtgacca gcggagtaag gagcgctccc tactgcatgg     1440

ggacttccac gcgttctccg ctgggcctgg actcttctcc tatatccgcc actgggacca     1500

gaatgagcgt tttctggtag tgcttaactt tggggatgtg ggcctctcgg ctggactgca     1560

ggcctccgac ctgcctgcca gcgccagcct gccagccaag gctgacctcc tgctcagcac     1620

ccagccaggc cgtgaggagg gctcccctct tgagctggaa cgcctgaaac tggagcctca     1680

cgaagggctg ctgctccgct tcccctacgc ggcctgactt cagcctgaca tggacccact     1740

acccttctcc tttccttccc aggccctttg gcttctgatt tttctctttt ttaaaaacaa     1800

acaaacaaac tgttgcagat tatgagtgaa cccccaaata gggtgttttc tgccttcaaa     1860

taaaagtcac ccctgcatgg tgaa                                            1884


<210>  113
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 
1               5                   10                  15      


Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 
            20                  25                  30          


Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 
        35                  40                  45              


Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser 
    50                  55                  60                  


Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 
65                  70                  75                  80  


Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 
                85                  90                  95      


Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu 
            100                 105                 110         


Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp 
        115                 120                 125             


Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala 
    130                 135                 140     


<210>  114
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  114

Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr 
            20                  25                  30          


Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp 
        35                  40                  45              


Ser Leu Leu Gln Ser Ala Lys Lys Lys 
    50                  55          


<210>  115
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  115

Ile Arg Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser 
1               5                   10                  15      


Trp Phe Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val 
            20                  25                  


<210>  116
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  116

Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val 
1               5                   10                  15      


Arg Asp Ile Glu Asn Leu Lys 
            20              


<210>  117
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  117

Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe 
1               5                   10                  15      


Ser Glu Asp 
            


<210>  118
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  118

Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu Ser 
1               5                   10                  15      


Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu Ser 
            20                  25                  30          


Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln Tyr 
        35                  40                  45              


Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser 
    50                  55                  60  


<210>  119
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  119

Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu 
1               5                   10                  15      


Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe 
            20                  25                  30          


Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln 
        35                  40                  45              


<210>  120
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  120

Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp 
1               5                   10                  15      


Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys 
            20                  25              


<210>  121
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  121

Gly Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu 
1               5                   10                  15      


Ser Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His 
            20                  25                  30          


Ala Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp 
        35                  40                  45              


Gln Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu 
    50                  55                  60                  


Ser Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro 
65                  70                  75                  80  


Ala Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly 
                85                  90                  95      


Ser Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu 
            100                 105                 110         


Leu Leu Arg Phe Pro Tyr Ala Ala 
        115                 120 


<210>  122
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 
1               5                   10                  15      


Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 
            20                  25                  30          


Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 
        35                  40                  45              


Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser 
    50                  55                  60                  


Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 
65                  70                  75                  80  


Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 
                85                  90                  95      


Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu 
            100                 105                 110         


Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp 
        115                 120                 125             


Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys 
    130                 135                 140                 


Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu 
145                 150                 155                 160 


Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu 
                165                 170                 175     


Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu 
            180                 185                 190         


Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr 
        195                 200                 205             


Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr 
    210                 215                 220                 


Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly 
225                 230                 235                 240 


Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser 
                245                 250                 255     


Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp 
            260                 265                 270         


Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu 
        275                 280                 285             


Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln 
305                 310                 315                 320 


Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln 
                325                 330                 335     


Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr 
            340                 345                 350         


Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly 
        355                 360                 365             


Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu 
    370                 375                 380                 


Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly 
385                 390                 395                 400 


Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly 
                405                 410                 415     


Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu 
            420                 425                 430         


Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly 
        435                 440                 445             


Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val 
    450                 455                 460                 


Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser 
465                 470                 475                 480 


Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu 
                485                 490                 495     


Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg 
            500                 505                 510         


Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala 
        515                 520                 525             


Ala 
    


<210>  123
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  123
000

<210>  124
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  124
000

<210>  125
<211>  187
<212>  DNA
<213>  Homo sapiens

<400>  125
agtaagcctc cgcagcccac tcggactgca gcctgtttgc cgcccgtcct cccattgcag       60

cactcggggc gacagagagg gaggaggcgc gcggggacgg ggacgcccag gaggacccac      120

tcgcgggtcc cgctccgctc cggcagcagc atggggaaag gacgcgcggg ccgagttggc      180

accacag                                                                187


<210>  126
<211>  178
<212>  DNA
<213>  Homo sapiens

<400>  126
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaaccagt tctgaatact cctctctcag attcaagtgg ttcaagaatg      120

ggaatgaatt gaatcgaaaa aacaaaccac aaaatatcaa gatacaaaaa aagccagg        178


<210>  127
<211>  122
<212>  DNA
<213>  Homo sapiens

<400>  127
gaagtcagaa cttcgcatta acaaagcatc actggctgat tctggagagt atatgtgcaa       60

agtgatcagc aaattaggaa atgacagtgc ctctgccaat atcaccatcg tggaatcaaa      120

cg                                                                     122


<210>  128
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  128
agatcatcac tggtatgcca gcctcaactg aaggagcata tgtgtcttca g                51


<210>  129
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  129
agtctcccat tagaatatca gtatccacag aaggagcaaa tacttcttca t                51


<210>  130
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  130
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgcttca tggtgaaaga cctttcaaac ccctcgagat      120

acttgtgcaa                                                             130


<210>  131
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  131
gtgcccaaat gagtttactg gtgatcgctg ccaaaactac gtaatggcca gcttctaca        59


<210>  132
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  132
agcatcttgg gattgaattt atgg                                              24


<210>  133
<211>  103
<212>  DNA
<213>  Homo sapiens

<400>  133
aggcggagga gctgtaccag aagagagtgc tgaccataac cggcatctgc atcgccctcc       60

ttgtggtcgg catcatgtgt gtggtggcct actgcaaaac caa                        103


<210>  134
<211>  127
<212>  DNA
<213>  Homo sapiens

<400>  134
gaaacagcgg aaaaagctgc atgaccgtct tcggcagagc cttcggtctg aacgaaacaa       60

tatgatgaac attgccaatg ggcctcacca tcctaaccca ccccccgaga atgtccagct      120

ggtgaat                                                                127


<210>  135
<211>  131
<212>  DNA
<213>  Homo sapiens

<400>  135
caatacgtat ctaaaaacgt catctccagt gagcatattg ttgagagaga agcagagaca       60

tccttttcca ccagtcacta tacttccaca gcccatcact ccactactgt cacccagact      120

cctagccaca g                                                           131


<210>  136
<211>  207
<212>  DNA
<213>  Homo sapiens

<400>  136
ctggagcaac ggacacactg aaagcatcct ttccgaaagc cactctgtaa tcgtgatgtc       60

atccgtagaa aacagtaggc acagcagccc aactgggggc ccaagaggac gtcttaatgg      120

cacaggaggc cctcgtgaat gtaacagctt cctcaggcat gccagagaaa cccctgattc      180

ctaccgagac tctcctcata gtgaaag                                          207


<210>  137
<211>  10299
<212>  DNA
<213>  Homo sapiens

<400>  137
gtatgtgtca gccatgacca ccccggctcg tatgtcacct gtagatttcc acacgccaag       60

ctcccccaaa tcgccccctt cggaaatgtc tccacccgtg tccagcatga cggtgtccat      120

gccttccatg gcggtcagcc ccttcatgga agaagagaga cctctacttc tcgtgacacc      180

accaaggctg cgggagaaga agtttgacca tcaccctcag cagttcagct ccttccacca      240

caaccccgcg catgacagta acagcctccc tgctagcccc ttgaggatag tggaggatga      300

ggagtatgaa acgacccaag agtacgagcc agcccaagag cctgttaaga aactcgccaa      360

tagccggcgg gccaaaagaa ccaagcccaa tggccacatt gctaacagat tggaagtgga      420

cagcaacaca agctcccaga gcagtaactc agagagtgaa acagaagatg aaagagtagg      480

tgaagatacg cctttcctgg gcatacagaa ccccctggca gccagtcttg aggcaacacc      540

tgccttccgc ctggctgaca gcaggactaa cccagcaggc cgcttctcga cacaggaaga      600

aatccaggcc aggctgtcta gtgtaattgc taaccaagac cctattgctg tataaaacct      660

aaataaacac atagattcac ctgtaaaact ttattttata taataaagta ttccacctta      720

aattaaacaa tttattttat tttagcagtt ctgcaaatag aaaacaggaa aaaaactttt      780

ataaattaaa tatatgtatg taaaaatgtg ttatgtgcca tatgtagcaa ttttttacag      840

tatttcaaaa cgagaaagat atcaatggtg cctttatgtt atgttatgtc gagagcaagt      900

tttgtacagt tacagtgatt gcttttccac agtatttctg caaaacctct catagattca      960

gtttttgctg gcttcttgtg cattgcatta tgatgttgac tggatgtatg atttgcaaga     1020

cttgcaactg tccctctgtt tgcttgtagt agcacccgat cagtatgtct tgtaatggca     1080

catccatcca gatatgcctc tcttgtgtat gaagttttct ttgctttcag aatatgaaat     1140

gagttgtgtc tactctgcca gccaaaggtt tgcctcattg ggctctgaga taatagtaga     1200

tccaacagca tgctactatt aaatacagca agaaactgca ttaagtaatg ttaaatatta     1260

ggaagaaagt aatactgtga tttaaaaaaa actatattat taatcagaag acagcttgct     1320

cttactaaaa ggagctctca tttactttat ttgattttat ttttcttgac aaaaagcaac     1380

agttttaggg atagcttaga aaatgggttc tggcttgcta tcagggtaaa tctaacacct     1440

tacaagagga ctgagtgtca ctttctctct gggggaatga tccagcagct tatctagttg     1500

acaatcaaaa cacggctgat aaaggtgcaa tcatttctga catgtatttt tcactgattt     1560

tgaagctagt gattggttgt gtcttcttgg ctcaaaaaga agcatattac ggcacaaaaa     1620

gcccagccca gacagcacat gcagcatttt gtctgaaata cttctagagt caaacgtgcc     1680

tgctgtacat agcgatgact tgtcatcata gggaagtatt tccatcgtag agtgttcaga     1740

aggagtgact gtataggtgg agagaagctt agtgactccg ttgaaatttt aaaatgtgga     1800

tgaccacccc tttctccccc ttatttttct tttatctttc catgttgcct tgatcaggtc     1860

ataactatgc atgaacattt tttatcagga atggccgatg tgtatgtgat ttgtaatcac     1920

aagtaatgat tcatcaggaa atgtcaatcc tgttggaaag attgcacctt tacttgcaga     1980

agtgaccccc acctgtgtcc tgacctctcc atttacaggc tctctcaccc atttccccca     2040

cctcctttaa tttttgcttt actgtcataa agtaggacta agattggtct aagcattgca     2100

tgttcttttg tgatggtaaa tccaaaggaa ggcctataag tattaacatt tgaaataact     2160

gctaattcag gaaaatggaa gaaaaaaaat tatttgaaac acagaaccca tttcatggcc     2220

tgcctgatat ctgtgaaatc agggctggag ctttacttag gattcacatg gcctcctagg     2280

aaccatggga caaatgggaa acaggttatc gggggattca tgaagtcagt gagagtaatt     2340

gcttcttttt tgcgggtgaa ctgaatgtat ttcttcacca aatcttgatg ttaacaatta     2400

aaaagaagaa atgacatgca agtaggtctt agcagaaaaa tgcaggctgg gcatgagtca     2460

tgttgttacc ctcccacatg ctcctacaat ccacagagat gcctgtctgc aggttcttga     2520

agttattgtt agtatttggt atctcaaatt tttcgtcact gttcacatgc cactttctct     2580

gtgcacagtg gtatcctcat ttgcttttta acctacactg aggagtcttt gtcaggttgc     2640

actgattttc caattctgca gtaatgagta agctcacggc atggggaaga agacagtcag     2700

tccaatgaag ttctctaaat tattttaaca ttgcctttga aggccttgac tcatccttag     2760

ctatttcaat gaagaaattc ctaccatgaa tttaaaaccc taaaaattct gtttcaaatt     2820

ctttgggcat tggggtactc agatatccca ttgtggaaga attttaagaa taaatagaag     2880

tttctgttga gaaccatgag caacatgttt cttacaatga gaattgctat gcattttaaa     2940

attgcaaata tatatgaaaa ttgaagacaa gaggaaattg tatttctaac ttgattctga     3000

tcactcacag aggtggcata ttattatagt tgggacatcc tttgcaccct tcataaaaaa     3060

ggccagctga ctgctcagca tcacctgcca aggccactag atttgtgttt acaggggtat     3120

ctctgtgatg cttgtcacat cactcttgac cacctctgtt aataaattcc gacagtgcag     3180

tggcgatcgg agtgtgaact tatgttccca gcatatggaa agctatctta ggttttaagg     3240

tagtagaaat tgcccaggag tttgacagca actttgtttc ccgggtctaa aatcgtatcc     3300

cactgaggtg tatgcagtgg agcataatac atgcaaatac atgcaaaact ccttttgttt     3360

cacctaagat tcactttcta tcttactttc ccttcctgcc tagtgtgact tttgccccca     3420

agagtgcctg gacagcattc tagtttctac aaaatggtcc tctgtgtagg tgaatgtgtc     3480

ccaaacctgc tatcactttc ttgtttcagt gtgactgtct tgttagaggt gaagtttatc     3540

cagggtaact tgctcactaa ctattccttt ttatggcctg gggttaaagg gcgcatggct     3600

cacactggtg aaaataagga aggcctggtc ttatcttgta ttaataatac tggctgcatt     3660

ccaccagcca gagatttcta tctgcgaaga cctatgaaac actgaagaga aatgtaggca     3720

gaaggaaatg gccacatatc acaagttcta ttatatattc ttttgtaaat acatattgta     3780

tattacttgg atgttttctt atatcattta ctgtcttttt gagttaatgt cagtttttac     3840

tctctcaact tactatgtaa cattgtaaat aacataatgt cctttattat ttatatttaa     3900

gcatctaaca tatagagttg ttttcatata agtttaagat aaatgtcaaa aatatatgtt     3960

cttttgtttt tctttgcttt aaaattatgt atcttttcct tttctttttt ttaagaataa     4020

tttattgttc aggagaaaga atgtatatgt aactgaaact atctgaagaa tgcacattga     4080

aggccgtgag gtactgataa actaaagaat ttattattca aaatactaag caataagtaa     4140

ttgtgattta tttaaagttt tgtccatttt ccatgaaaga catactgcaa taaaaatgct     4200

actctgtgga gacctgggag tgttgctcag cagactacag cttcagtctg ttagaccagc     4260

acctttcatc tcattcccat agttatgcta atttaggatt gtgttccatg gaccccatga     4320

tcaccttgtc tatacgttgc ttcttgtctg tccattgctt ttgccacacc acctgttctc     4380

aaatcatctc ctccctacca atgctgttta tcactttctt ccttgttgaa gaggccacac     4440

aaccagacag tactatgctt cctttttcct ccatacacaa taacagagag agaatattct     4500

agggcatgac tgcctggatc ctggctgttg ctatcttttg tagtggcagt aagaaactcc     4560

ttcagactaa tgaaaatgtc aacgtgccat tcaatcacga aaggtaacga aaaatgctct     4620

catggttcaa atagtccaat ggcccatagt ggcctaaaag gcagccagtt gacacctggc     4680

catgctaagc ttccttatac catccgctaa tgactttcca ttgggcccac aatttacgga     4740

ttcataattt taaaagagga gaaggccaag ttaggttcat tccccttatt ctgtcaataa     4800

aacaaatcaa actcatgtct atctaactgc tcagggagga gcctttgcat gagaaaattc     4860

tcatattcta agactgagtc atagaaatga gggtattact tttcttactg caattaacct     4920

aaacaaaagc catattttaa caaatagata tttgcatggt acccttcata tattccaagc     4980

atttcactca ttattccagg taggttaaga gcttctgaag tgtatgaagt aaaggtcagc     5040

aatcctttgg ggtgaacagt ggcctccttt ggagtttggg ggtaacctga gacttcccac     5100

caatgtccac ctccatctgt gtacctaatt cctattacct agttatggct cctctaggat     5160

catttccaaa cactctggat gtccaggaaa tttaaattgt agcttttgac tgagctagtt     5220

tttcctattt atattaataa attttcaaaa atgcttgaaa tcttcacatt tgcaacaact     5280

ttagttttca tgcacataca aacacagaga gacaaaaatt ccaaacagac actctccaaa     5340

agccaccaca ctctttcact tgctctatag tcatttagcc aaccagccat gcagagaata     5400

tttaaaactt aaagattgag acattattct cagtttttgc tgaggctttg taacgaaatt     5460

gaacactata agcagctatt gtagtaattt tggttaaaat tgtttgcctg ggatatagta     5520

tttgaggcag aagcacgtgt gtgaaggagg tgaggtggtt tggaaagagt gaagactcgc     5580

agccagattg aatgtctgga taattactat aattctccct tcttggttga aaccatgttc     5640

tctcttgatt tttaaaccca ggctgcctct ggaaacaagc aaacctgagt ctttctaacc     5700

tgagtcttcc caatcattag atttcttttc tgtcctaacg atgaatgata aaaggacttg     5760

atgttcacaa tttggggtta taaggcaggt ctgaaatctg gagactcaag atgctggaag     5820

gagtggaaag tttcgatgac tttatatgaa tcactttgca ctctatgttt ggcttgtcct     5880

ctttgaaact gatttactaa aataaatgta agggaactat tactccaaaa gattaacttg     5940

gcaggaaata ccaatacttt cagtttatga aagacaaaac tgtcttgttg ctacaggaag     6000

ctgcaatgtt cctaaccttt aaggttggtg ttgaataggg tggtcatgcc ctcccctgca     6060

ggtatcttta ggctcctgtt gacctcctgg tactataact gttcgtcttc tctgggtagc     6120

tattgatttt gaactttaac atgcttcaaa actttattca tcagggaaat aggaaaagag     6180

ttttgttacc tggaggaaat ctattgtgat ctacctgagc tttttaaaaa cagaccagga     6240

gaaggaaacc agtaattttt aaagaagaga cagagaatgg gataatagtt tcacccagga     6300

tctctttcta accctttccc ttcaaatgaa cttattggaa cagaattgga aagaagaaag     6360

gacatctctg cccaccccac aggatgccaa aaaggctaaa gaattacctc tgtagattta     6420

aacatcttta atggcttatg tatagatttg ctaatacaga gagaaatgaa ctattaaata     6480

aaaatcacat tttataatat ttttatggct taaaacatcc tttatctcct ttttgttctc     6540

tctacatgat atggtaagtg atgaggaaaa tttaggctca ggaaggttaa aatctttctt     6600

ggagttacac atctaagaga gctgcagagc tgacacttgt acccaggttt tctgactgca     6660

aatccagttt ctttctattg cgttcttccc ctttccctgc ctcaagcaga aacaggtttt     6720

ttattttcaa cctttatgta tacagtatgt tatgttacat ctacagctaa gtttcttttt     6780

agaagaatgt gagcccttct agctttggtt tagagtgatt ctagaagcca atttccttgg     6840

cttagtgatt ctatgcacct ttcctaaact tagctttcta aggaaatgaa gtgtacgagt     6900

gagaatgaat tcacaatttc gacatgtagg tagcatccta aagtgaaaag aggaggaaat     6960

ttgtggtcaa agcactctcc ccaccactta gaaacttact gactgtgggc agcttcctcc     7020

tccaagtttc cttcctgatt tacaagaccg tggtgtggtc aggattaaac ttgaatacat     7080

gtaaggaagc ctgaaagtgt ctaacacata gcgagtattc aaatgccacc ttctatttga     7140

tccttcccct ccagttcctt aagttttgga atctaggttt ctcagttcca aatggattga     7200

catttgcata tccccattgc acaatggatc aaataaactt tatgttatca tttctccaac     7260

atagtgccag taagcaaatc ctttttaata acaacagtat gttgagaaac atatcaccaa     7320

ataatattta actttgtagc tttgataagt tctttaggtt ttggttttgg ttttgttttc     7380

tgagacaggg tcttgatctg tcacccagac tggagtgcaa tggttcaatt ttagctcact     7440

gcaacctgta actcctgagc tcaagtgatc ctcccacctc agcctctcaa gtagctggga     7500

ctacaggtgt gctccaccat gcccagcgat tttttttttt tttttttttt ttttttttgg     7560

tagggacaag gtctcgctat gttgcccagg ctggtcttca attcctggcc ttaagtgatc     7620

ctcctgcctc ggcctcccaa agtgctggaa ttacaggcat gagccaccac ccataacttt     7680

atgtttgttt ttttgatgca gtataagttc agcttgcttc ttatgcagcc ataccatttc     7740

atgttaactc tgatttttag cagcttatta cattagtgtt ttattattaa tataatttta     7800

cagaaattta ctaaaccatg actctgtaga gttttaataa tactacctcc aaacatcatt     7860

gcaaacatct agaagaatga acaaaaatga tcttagatcg acagtatatc tgtttgtctt     7920

agtttctaca caggatgttc agacatattc catttcttta aaaaaaaaat atatatatat     7980

atatatatat ataggcctgg cacggtggct catgactgta atcccagcac tttgggaggc     8040

ttaggcaggc aaatcacctg aggtcaggag tttgagactg gcctgaccaa catggtgaaa     8100

cctcgtctct attaaaatta caaaaattag ccgggcgtgg tggcacatgc ctgtaatccc     8160

agctactcgg gaggctgagg caggagaatc acttgaacct gggaggcaga ggttgcagtg     8220

agttgagatc acgccattgc actccagcct tggtgacaag agtgaaactc cgtctcaaaa     8280

aaaaaaaaaa tatgtatata tatatatata tatatatata tatatatata tatatatata     8340

taaaatccca ccaaaagtct gcagagtgac caaattagac ggctctggtt tcagattaaa     8400

ttctaaatgt gagaaaccac atagctccca tgatccatcc aataattcct cacgtcctct     8460

tcactcttta ctccatgcat aaaacagaat ttttttttct catcctgggt atgaagcaat     8520

taataattta cggatttagc ctatttggat tcaatccctt caaactccat actacatcca     8580

aggtggaagt gacttaaact ctgatatcaa tcatcaggct tgtaatatag gctttgttaa     8640

tggcaggaga gtctaataaa actttctgtt ccttatcctt catttaaatg aaaaactttt     8700

tattgaaaac aatcataact ctagctcatc ataaatataa ttcatgagga cattttatta     8760

tttttatatt aaagaaataa tattatagat gtaaactttg cacctttcta attattatca     8820

tgagttaagc taatacttgt cttctggtcc ctagatgatg attctttttt gccttactgg     8880

aggagccctt gtcttgaagt gagttgcttc aacagcagag gacttctagt ttctcccagt     8940

tgagcctaaa gtgaactttt catcttcttc agaggaaggg gcttccttga tttgtacttt     9000

tgtggctcct cagataacac agacaatttt atcttggatc ccaggttctc ttcaccatta     9060

agaataagaa agagagaaaa tgctgtgcat gacagccacc tactccaaac tacccaaccc     9120

cctgtaacca ggtaccttcc aacaacgaga tgattctgcc ctcactcaag agtctccccc     9180

acaaagattc cattctccct ttacttttta ttttttattt ttttgcaaaa caaaggcctc     9240

ctttagtacc tccttagttt ataaccctta tcttcccagc tcttcccttc actgatacct     9300

ctgatttcaa aagttctgaa gtcggaagac cacacaattt cagactgtga acagaaattc     9360

agtcagaaat tattggagtt agaaagaatt tagagaaatt gtattgaact agaaagtcct     9420

ctttgattag tggtggccct ttagaaagtt ctagggcaga gtcccatggt gtttcatctt     9480

ttccatgatt tgcttgacca aaaacttttc tttcacaaca tgaaaatatg ctaatccacc     9540

acacattttg gattctgctc tgtttgcctg aggtgttaga tctctagcca ggactgtgaa     9600

gggaaggaac ttgaatcctt cctattgagc tattaatgca gagtcagtga gatgaagggt     9660

tccactcggg gtcaaaatca tgtcagttac caagcaaagg agcaagtaag gggaaacatc     9720

tcctcatctg gttagtggag ccacatttca cccactgatc aagccagacc tgagcaatag     9780

tctagatttc tccctccaca tctaattggt gacaatggtg attgtaccac tgacaggtca     9840

cacaagtcca caccctcctt cacagcctca ctgcttcggc tcttgtttat gctcttatca     9900

gcatctgtca ctaggatcca tttgtctcct gactcatcta cttcctttca ctcccctggg     9960

ccatccttca catcatgcta gaagactgtg tctaacttgc agaacttatt gtgtcaatct    10020

cctggttacg gcccctccat ggctccccac ctgacatagg aggcccttca caatctggct    10080

tctgtcactc ataacttgtc tccagccttc attcttcagt ctgattttat ggttttctag    10140

ttccccaata caccacacca gtgtttatga aaccctagtc attggcctac gaactttatg    10200

attattgaca tattcatgta ccacctgtat tattttttgc atagtgttta tttttaattg    10260

actacatttt taactacaat aaagtaattt caactaaaa                           10299


<210>  138
<211>  11669
<212>  DNA
<213>  Homo sapiens

<400>  138
agtaagcctc cgcagcccac tcggactgca gcctgtttgc cgcccgtcct cccattgcag       60

cactcggggc gacagagagg gaggaggcgc gcggggacgg ggacgcccag gaggacccac      120

tcgcgggtcc cgctccgctc cggcagcagc atggggaaag gacgcgcggg ccgagttggc      180

accacagcct tgcctccccg attgaaagag atgaaaagcc aggaatcggc tgcaggttcc      240

aaactagtcc ttcggtgtga aaccagttct gaatactcct ctctcagatt caagtggttc      300

aagaatggga atgaattgaa tcgaaaaaac aaaccacaaa atatcaagat acaaaaaaag      360

ccagggaagt cagaacttcg cattaacaaa gcatcactgg ctgattctgg agagtatatg      420

tgcaaagtga tcagcaaatt aggaaatgac agtgcctctg ccaatatcac catcgtggaa      480

tcaaacgaga tcatcactgg tatgccagcc tcaactgaag gagcatatgt gtcttcagag      540

tctcccatta gaatatcagt atccacagaa ggagcaaata cttcttcatc tacatctaca      600

tccaccactg ggacaagcca tcttgtaaaa tgtgcggaga aggagaaaac tttctgtgtg      660

aatggagggg agtgcttcat ggtgaaagac ctttcaaacc cctcgagata cttgtgcaag      720

tgcccaaatg agtttactgg tgatcgctgc caaaactacg taatggccag cttctacaag      780

catcttggga ttgaatttat ggaggcggag gagctgtacc agaagagagt gctgaccata      840

accggcatct gcatcgccct ccttgtggtc ggcatcatgt gtgtggtggc ctactgcaaa      900

accaagaaac agcggaaaaa gctgcatgac cgtcttcggc agagccttcg gtctgaacga      960

aacaatatga tgaacattgc caatgggcct caccatccta acccaccccc cgagaatgtc     1020

cagctggtga atcaatacgt atctaaaaac gtcatctcca gtgagcatat tgttgagaga     1080

gaagcagaga catccttttc caccagtcac tatacttcca cagcccatca ctccactact     1140

gtcacccaga ctcctagcca cagctggagc aacggacaca ctgaaagcat cctttccgaa     1200

agccactctg taatcgtgat gtcatccgta gaaaacagta ggcacagcag cccaactggg     1260

ggcccaagag gacgtcttaa tggcacagga ggccctcgtg aatgtaacag cttcctcagg     1320

catgccagag aaacccctga ttcctaccga gactctcctc atagtgaaag gtatgtgtca     1380

gccatgacca ccccggctcg tatgtcacct gtagatttcc acacgccaag ctcccccaaa     1440

tcgccccctt cggaaatgtc tccacccgtg tccagcatga cggtgtccat gccttccatg     1500

gcggtcagcc ccttcatgga agaagagaga cctctacttc tcgtgacacc accaaggctg     1560

cgggagaaga agtttgacca tcaccctcag cagttcagct ccttccacca caaccccgcg     1620

catgacagta acagcctccc tgctagcccc ttgaggatag tggaggatga ggagtatgaa     1680

acgacccaag agtacgagcc agcccaagag cctgttaaga aactcgccaa tagccggcgg     1740

gccaaaagaa ccaagcccaa tggccacatt gctaacagat tggaagtgga cagcaacaca     1800

agctcccaga gcagtaactc agagagtgaa acagaagatg aaagagtagg tgaagatacg     1860

cctttcctgg gcatacagaa ccccctggca gccagtcttg aggcaacacc tgccttccgc     1920

ctggctgaca gcaggactaa cccagcaggc cgcttctcga cacaggaaga aatccaggcc     1980

aggctgtcta gtgtaattgc taaccaagac cctattgctg tataaaacct aaataaacac     2040

atagattcac ctgtaaaact ttattttata taataaagta ttccacctta aattaaacaa     2100

tttattttat tttagcagtt ctgcaaatag aaaacaggaa aaaaactttt ataaattaaa     2160

tatatgtatg taaaaatgtg ttatgtgcca tatgtagcaa ttttttacag tatttcaaaa     2220

cgagaaagat atcaatggtg cctttatgtt atgttatgtc gagagcaagt tttgtacagt     2280

tacagtgatt gcttttccac agtatttctg caaaacctct catagattca gtttttgctg     2340

gcttcttgtg cattgcatta tgatgttgac tggatgtatg atttgcaaga cttgcaactg     2400

tccctctgtt tgcttgtagt agcacccgat cagtatgtct tgtaatggca catccatcca     2460

gatatgcctc tcttgtgtat gaagttttct ttgctttcag aatatgaaat gagttgtgtc     2520

tactctgcca gccaaaggtt tgcctcattg ggctctgaga taatagtaga tccaacagca     2580

tgctactatt aaatacagca agaaactgca ttaagtaatg ttaaatatta ggaagaaagt     2640

aatactgtga tttaaaaaaa actatattat taatcagaag acagcttgct cttactaaaa     2700

ggagctctca tttactttat ttgattttat ttttcttgac aaaaagcaac agttttaggg     2760

atagcttaga aaatgggttc tggcttgcta tcagggtaaa tctaacacct tacaagagga     2820

ctgagtgtca ctttctctct gggggaatga tccagcagct tatctagttg acaatcaaaa     2880

cacggctgat aaaggtgcaa tcatttctga catgtatttt tcactgattt tgaagctagt     2940

gattggttgt gtcttcttgg ctcaaaaaga agcatattac ggcacaaaaa gcccagccca     3000

gacagcacat gcagcatttt gtctgaaata cttctagagt caaacgtgcc tgctgtacat     3060

agcgatgact tgtcatcata gggaagtatt tccatcgtag agtgttcaga aggagtgact     3120

gtataggtgg agagaagctt agtgactccg ttgaaatttt aaaatgtgga tgaccacccc     3180

tttctccccc ttatttttct tttatctttc catgttgcct tgatcaggtc ataactatgc     3240

atgaacattt tttatcagga atggccgatg tgtatgtgat ttgtaatcac aagtaatgat     3300

tcatcaggaa atgtcaatcc tgttggaaag attgcacctt tacttgcaga agtgaccccc     3360

acctgtgtcc tgacctctcc atttacaggc tctctcaccc atttccccca cctcctttaa     3420

tttttgcttt actgtcataa agtaggacta agattggtct aagcattgca tgttcttttg     3480

tgatggtaaa tccaaaggaa ggcctataag tattaacatt tgaaataact gctaattcag     3540

gaaaatggaa gaaaaaaaat tatttgaaac acagaaccca tttcatggcc tgcctgatat     3600

ctgtgaaatc agggctggag ctttacttag gattcacatg gcctcctagg aaccatggga     3660

caaatgggaa acaggttatc gggggattca tgaagtcagt gagagtaatt gcttcttttt     3720

tgcgggtgaa ctgaatgtat ttcttcacca aatcttgatg ttaacaatta aaaagaagaa     3780

atgacatgca agtaggtctt agcagaaaaa tgcaggctgg gcatgagtca tgttgttacc     3840

ctcccacatg ctcctacaat ccacagagat gcctgtctgc aggttcttga agttattgtt     3900

agtatttggt atctcaaatt tttcgtcact gttcacatgc cactttctct gtgcacagtg     3960

gtatcctcat ttgcttttta acctacactg aggagtcttt gtcaggttgc actgattttc     4020

caattctgca gtaatgagta agctcacggc atggggaaga agacagtcag tccaatgaag     4080

ttctctaaat tattttaaca ttgcctttga aggccttgac tcatccttag ctatttcaat     4140

gaagaaattc ctaccatgaa tttaaaaccc taaaaattct gtttcaaatt ctttgggcat     4200

tggggtactc agatatccca ttgtggaaga attttaagaa taaatagaag tttctgttga     4260

gaaccatgag caacatgttt cttacaatga gaattgctat gcattttaaa attgcaaata     4320

tatatgaaaa ttgaagacaa gaggaaattg tatttctaac ttgattctga tcactcacag     4380

aggtggcata ttattatagt tgggacatcc tttgcaccct tcataaaaaa ggccagctga     4440

ctgctcagca tcacctgcca aggccactag atttgtgttt acaggggtat ctctgtgatg     4500

cttgtcacat cactcttgac cacctctgtt aataaattcc gacagtgcag tggcgatcgg     4560

agtgtgaact tatgttccca gcatatggaa agctatctta ggttttaagg tagtagaaat     4620

tgcccaggag tttgacagca actttgtttc ccgggtctaa aatcgtatcc cactgaggtg     4680

tatgcagtgg agcataatac atgcaaatac atgcaaaact ccttttgttt cacctaagat     4740

tcactttcta tcttactttc ccttcctgcc tagtgtgact tttgccccca agagtgcctg     4800

gacagcattc tagtttctac aaaatggtcc tctgtgtagg tgaatgtgtc ccaaacctgc     4860

tatcactttc ttgtttcagt gtgactgtct tgttagaggt gaagtttatc cagggtaact     4920

tgctcactaa ctattccttt ttatggcctg gggttaaagg gcgcatggct cacactggtg     4980

aaaataagga aggcctggtc ttatcttgta ttaataatac tggctgcatt ccaccagcca     5040

gagatttcta tctgcgaaga cctatgaaac actgaagaga aatgtaggca gaaggaaatg     5100

gccacatatc acaagttcta ttatatattc ttttgtaaat acatattgta tattacttgg     5160

atgttttctt atatcattta ctgtcttttt gagttaatgt cagtttttac tctctcaact     5220

tactatgtaa cattgtaaat aacataatgt cctttattat ttatatttaa gcatctaaca     5280

tatagagttg ttttcatata agtttaagat aaatgtcaaa aatatatgtt cttttgtttt     5340

tctttgcttt aaaattatgt atcttttcct tttctttttt ttaagaataa tttattgttc     5400

aggagaaaga atgtatatgt aactgaaact atctgaagaa tgcacattga aggccgtgag     5460

gtactgataa actaaagaat ttattattca aaatactaag caataagtaa ttgtgattta     5520

tttaaagttt tgtccatttt ccatgaaaga catactgcaa taaaaatgct actctgtgga     5580

gacctgggag tgttgctcag cagactacag cttcagtctg ttagaccagc acctttcatc     5640

tcattcccat agttatgcta atttaggatt gtgttccatg gaccccatga tcaccttgtc     5700

tatacgttgc ttcttgtctg tccattgctt ttgccacacc acctgttctc aaatcatctc     5760

ctccctacca atgctgttta tcactttctt ccttgttgaa gaggccacac aaccagacag     5820

tactatgctt cctttttcct ccatacacaa taacagagag agaatattct agggcatgac     5880

tgcctggatc ctggctgttg ctatcttttg tagtggcagt aagaaactcc ttcagactaa     5940

tgaaaatgtc aacgtgccat tcaatcacga aaggtaacga aaaatgctct catggttcaa     6000

atagtccaat ggcccatagt ggcctaaaag gcagccagtt gacacctggc catgctaagc     6060

ttccttatac catccgctaa tgactttcca ttgggcccac aatttacgga ttcataattt     6120

taaaagagga gaaggccaag ttaggttcat tccccttatt ctgtcaataa aacaaatcaa     6180

actcatgtct atctaactgc tcagggagga gcctttgcat gagaaaattc tcatattcta     6240

agactgagtc atagaaatga gggtattact tttcttactg caattaacct aaacaaaagc     6300

catattttaa caaatagata tttgcatggt acccttcata tattccaagc atttcactca     6360

ttattccagg taggttaaga gcttctgaag tgtatgaagt aaaggtcagc aatcctttgg     6420

ggtgaacagt ggcctccttt ggagtttggg ggtaacctga gacttcccac caatgtccac     6480

ctccatctgt gtacctaatt cctattacct agttatggct cctctaggat catttccaaa     6540

cactctggat gtccaggaaa tttaaattgt agcttttgac tgagctagtt tttcctattt     6600

atattaataa attttcaaaa atgcttgaaa tcttcacatt tgcaacaact ttagttttca     6660

tgcacataca aacacagaga gacaaaaatt ccaaacagac actctccaaa agccaccaca     6720

ctctttcact tgctctatag tcatttagcc aaccagccat gcagagaata tttaaaactt     6780

aaagattgag acattattct cagtttttgc tgaggctttg taacgaaatt gaacactata     6840

agcagctatt gtagtaattt tggttaaaat tgtttgcctg ggatatagta tttgaggcag     6900

aagcacgtgt gtgaaggagg tgaggtggtt tggaaagagt gaagactcgc agccagattg     6960

aatgtctgga taattactat aattctccct tcttggttga aaccatgttc tctcttgatt     7020

tttaaaccca ggctgcctct ggaaacaagc aaacctgagt ctttctaacc tgagtcttcc     7080

caatcattag atttcttttc tgtcctaacg atgaatgata aaaggacttg atgttcacaa     7140

tttggggtta taaggcaggt ctgaaatctg gagactcaag atgctggaag gagtggaaag     7200

tttcgatgac tttatatgaa tcactttgca ctctatgttt ggcttgtcct ctttgaaact     7260

gatttactaa aataaatgta agggaactat tactccaaaa gattaacttg gcaggaaata     7320

ccaatacttt cagtttatga aagacaaaac tgtcttgttg ctacaggaag ctgcaatgtt     7380

cctaaccttt aaggttggtg ttgaataggg tggtcatgcc ctcccctgca ggtatcttta     7440

ggctcctgtt gacctcctgg tactataact gttcgtcttc tctgggtagc tattgatttt     7500

gaactttaac atgcttcaaa actttattca tcagggaaat aggaaaagag ttttgttacc     7560

tggaggaaat ctattgtgat ctacctgagc tttttaaaaa cagaccagga gaaggaaacc     7620

agtaattttt aaagaagaga cagagaatgg gataatagtt tcacccagga tctctttcta     7680

accctttccc ttcaaatgaa cttattggaa cagaattgga aagaagaaag gacatctctg     7740

cccaccccac aggatgccaa aaaggctaaa gaattacctc tgtagattta aacatcttta     7800

atggcttatg tatagatttg ctaatacaga gagaaatgaa ctattaaata aaaatcacat     7860

tttataatat ttttatggct taaaacatcc tttatctcct ttttgttctc tctacatgat     7920

atggtaagtg atgaggaaaa tttaggctca ggaaggttaa aatctttctt ggagttacac     7980

atctaagaga gctgcagagc tgacacttgt acccaggttt tctgactgca aatccagttt     8040

ctttctattg cgttcttccc ctttccctgc ctcaagcaga aacaggtttt ttattttcaa     8100

cctttatgta tacagtatgt tatgttacat ctacagctaa gtttcttttt agaagaatgt     8160

gagcccttct agctttggtt tagagtgatt ctagaagcca atttccttgg cttagtgatt     8220

ctatgcacct ttcctaaact tagctttcta aggaaatgaa gtgtacgagt gagaatgaat     8280

tcacaatttc gacatgtagg tagcatccta aagtgaaaag aggaggaaat ttgtggtcaa     8340

agcactctcc ccaccactta gaaacttact gactgtgggc agcttcctcc tccaagtttc     8400

cttcctgatt tacaagaccg tggtgtggtc aggattaaac ttgaatacat gtaaggaagc     8460

ctgaaagtgt ctaacacata gcgagtattc aaatgccacc ttctatttga tccttcccct     8520

ccagttcctt aagttttgga atctaggttt ctcagttcca aatggattga catttgcata     8580

tccccattgc acaatggatc aaataaactt tatgttatca tttctccaac atagtgccag     8640

taagcaaatc ctttttaata acaacagtat gttgagaaac atatcaccaa ataatattta     8700

actttgtagc tttgataagt tctttaggtt ttggttttgg ttttgttttc tgagacaggg     8760

tcttgatctg tcacccagac tggagtgcaa tggttcaatt ttagctcact gcaacctgta     8820

actcctgagc tcaagtgatc ctcccacctc agcctctcaa gtagctggga ctacaggtgt     8880

gctccaccat gcccagcgat tttttttttt tttttttttt ttttttttgg tagggacaag     8940

gtctcgctat gttgcccagg ctggtcttca attcctggcc ttaagtgatc ctcctgcctc     9000

ggcctcccaa agtgctggaa ttacaggcat gagccaccac ccataacttt atgtttgttt     9060

ttttgatgca gtataagttc agcttgcttc ttatgcagcc ataccatttc atgttaactc     9120

tgatttttag cagcttatta cattagtgtt ttattattaa tataatttta cagaaattta     9180

ctaaaccatg actctgtaga gttttaataa tactacctcc aaacatcatt gcaaacatct     9240

agaagaatga acaaaaatga tcttagatcg acagtatatc tgtttgtctt agtttctaca     9300

caggatgttc agacatattc catttcttta aaaaaaaaat atatatatat atatatatat     9360

ataggcctgg cacggtggct catgactgta atcccagcac tttgggaggc ttaggcaggc     9420

aaatcacctg aggtcaggag tttgagactg gcctgaccaa catggtgaaa cctcgtctct     9480

attaaaatta caaaaattag ccgggcgtgg tggcacatgc ctgtaatccc agctactcgg     9540

gaggctgagg caggagaatc acttgaacct gggaggcaga ggttgcagtg agttgagatc     9600

acgccattgc actccagcct tggtgacaag agtgaaactc cgtctcaaaa aaaaaaaaaa     9660

tatgtatata tatatatata tatatatata tatatatata tatatatata taaaatccca     9720

ccaaaagtct gcagagtgac caaattagac ggctctggtt tcagattaaa ttctaaatgt     9780

gagaaaccac atagctccca tgatccatcc aataattcct cacgtcctct tcactcttta     9840

ctccatgcat aaaacagaat ttttttttct catcctgggt atgaagcaat taataattta     9900

cggatttagc ctatttggat tcaatccctt caaactccat actacatcca aggtggaagt     9960

gacttaaact ctgatatcaa tcatcaggct tgtaatatag gctttgttaa tggcaggaga    10020

gtctaataaa actttctgtt ccttatcctt catttaaatg aaaaactttt tattgaaaac    10080

aatcataact ctagctcatc ataaatataa ttcatgagga cattttatta tttttatatt    10140

aaagaaataa tattatagat gtaaactttg cacctttcta attattatca tgagttaagc    10200

taatacttgt cttctggtcc ctagatgatg attctttttt gccttactgg aggagccctt    10260

gtcttgaagt gagttgcttc aacagcagag gacttctagt ttctcccagt tgagcctaaa    10320

gtgaactttt catcttcttc agaggaaggg gcttccttga tttgtacttt tgtggctcct    10380

cagataacac agacaatttt atcttggatc ccaggttctc ttcaccatta agaataagaa    10440

agagagaaaa tgctgtgcat gacagccacc tactccaaac tacccaaccc cctgtaacca    10500

ggtaccttcc aacaacgaga tgattctgcc ctcactcaag agtctccccc acaaagattc    10560

cattctccct ttacttttta ttttttattt ttttgcaaaa caaaggcctc ctttagtacc    10620

tccttagttt ataaccctta tcttcccagc tcttcccttc actgatacct ctgatttcaa    10680

aagttctgaa gtcggaagac cacacaattt cagactgtga acagaaattc agtcagaaat    10740

tattggagtt agaaagaatt tagagaaatt gtattgaact agaaagtcct ctttgattag    10800

tggtggccct ttagaaagtt ctagggcaga gtcccatggt gtttcatctt ttccatgatt    10860

tgcttgacca aaaacttttc tttcacaaca tgaaaatatg ctaatccacc acacattttg    10920

gattctgctc tgtttgcctg aggtgttaga tctctagcca ggactgtgaa gggaaggaac    10980

ttgaatcctt cctattgagc tattaatgca gagtcagtga gatgaagggt tccactcggg    11040

gtcaaaatca tgtcagttac caagcaaagg agcaagtaag gggaaacatc tcctcatctg    11100

gttagtggag ccacatttca cccactgatc aagccagacc tgagcaatag tctagatttc    11160

tccctccaca tctaattggt gacaatggtg attgtaccac tgacaggtca cacaagtcca    11220

caccctcctt cacagcctca ctgcttcggc tcttgtttat gctcttatca gcatctgtca    11280

ctaggatcca tttgtctcct gactcatcta cttcctttca ctcccctggg ccatccttca    11340

catcatgcta gaagactgtg tctaacttgc agaacttatt gtgtcaatct cctggttacg    11400

gcccctccat ggctccccac ctgacatagg aggcccttca caatctggct tctgtcactc    11460

ataacttgtc tccagccttc attcttcagt ctgattttat ggttttctag ttccccaata    11520

caccacacca gtgtttatga aaccctagtc attggcctac gaactttatg attattgaca    11580

tattcatgta ccacctgtat tattttttgc atagtgttta tttttaattg actacatttt    11640

taactacaat aaagtaattt caactaaaa                                      11669


<210>  139
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr 
1               5                   10          


<210>  140
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  140

Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly 
1               5                   10                  15      


Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu 
            20                  25                  30          


Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys 
        35                  40                  45              


Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro 
    50                  55              


<210>  141
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  141

Lys Ser Glu Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu 
1               5                   10                  15      


Tyr Met Cys Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala 
            20                  25                  30          


Asn Ile Thr Ile Val Glu Ser Asn 
        35                  40  


<210>  142
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  142

Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser Ser 
1               5                   10                  15      


<210>  143
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  143

Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly Ala Asn Thr Ser Ser 
1               5                   10                  15      


<210>  144
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  144

Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu 
1               5                   10                  15      


Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys 
            20                  25                  30          


Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
        35                  40          


<210>  145
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  145

Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala 
1               5                   10                  15      


Ser Phe Tyr 
            


<210>  146
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  146

His Leu Gly Ile Glu Phe Met 
1               5           


<210>  147
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  147

Ala Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys 
1               5                   10                  15      


Ile Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys 
            20                  25                  30          


Thr 
    


<210>  148
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  148

Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser 
1               5                   10                  15      


Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn 
            20                  25                  30          


Pro Pro Pro Glu Asn Val Gln Leu Val Asn 
        35                  40          


<210>  149
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  149

Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile Val Glu Arg 
1               5                   10                  15      


Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His 
            20                  25                  30          


His Ser Thr Thr Val Thr Gln Thr Pro Ser His 
        35                  40              


<210>  150
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  150

Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
1               5                   10                  15      


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
            20                  25                  30          


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
        35                  40                  45              


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
    50                  55                  60                  


Pro His Ser Glu 
65              


<210>  151
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  151

Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe 
1               5                   10                  15      


His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro 
            20                  25                  30          


Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe 
        35                  40                  45              


Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg 
    50                  55                  60                  


Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser Ser Phe His His 
65                  70                  75                  80  


Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile 
                85                  90                  95      


Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln 
            100                 105                 110         


Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys 
        115                 120                 125             


Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser 
    130                 135                 140                 


Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly 
145                 150                 155                 160 


Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu 
                165                 170                 175     


Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala 
            180                 185                 190         


Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val 
        195                 200                 205             


Ile Ala Asn Gln Asp Pro Ile Ala Val 
    210                 215         


<210>  152
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly Ala Asn Thr 
    130                 135                 140                 


Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys 
145                 150                 155                 160 


Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe 
                165                 170                 175     


Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro 
            180                 185                 190         


Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe 
        195                 200                 205             


Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln 
    210                 215                 220                 


Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val 
225                 230                 235                 240 


Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys 
                245                 250                 255     


Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn 
            260                 265                 270         


Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu 
        275                 280                 285             


Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser 
    290                 295                 300                 


Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His 
305                 310                 315                 320 


Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser 
                325                 330                 335     


His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His 
            340                 345                 350         


Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro 
        355                 360                 365             


Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu 
    370                 375                 380                 


Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg 
385                 390                 395                 400 


Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala 
                405                 410                 415     


Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro 
            420                 425                 430         


Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro 
        435                 440                 445             


Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu 
    450                 455                 460                 


Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln 
465                 470                 475                 480 


Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu 
                485                 490                 495     


Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr 
            500                 505                 510         


Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser 
        515                 520                 525             


Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu 
    530                 535                 540                 


Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu 
545                 550                 555                 560 


Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln 
                565                 570                 575     


Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala 
            580                 585                 590         


Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile 
        595                 600                 605             


Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
    610                 615                 620                 


<210>  153
<211>  11482
<212>  DNA
<213>  Homo sapiens

<400>  153
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaaccagt tctgaatact cctctctcag attcaagtgg ttcaagaatg      120

ggaatgaatt gaatcgaaaa aacaaaccac aaaatatcaa gatacaaaaa aagccaggga      180

agtcagaact tcgcattaac aaagcatcac tggctgattc tggagagtat atgtgcaaag      240

tgatcagcaa attaggaaat gacagtgcct ctgccaatat caccatcgtg gaatcaaacg      300

agatcatcac tggtatgcca gcctcaactg aaggagcata tgtgtcttca gagtctccca      360

ttagaatatc agtatccaca gaaggagcaa atacttcttc atctacatct acatccacca      420

ctgggacaag ccatcttgta aaatgtgcgg agaaggagaa aactttctgt gtgaatggag      480

gggagtgctt catggtgaaa gacctttcaa acccctcgag atacttgtgc aagtgcccaa      540

atgagtttac tggtgatcgc tgccaaaact acgtaatggc cagcttctac aagcatcttg      600

ggattgaatt tatggaggcg gaggagctgt accagaagag agtgctgacc ataaccggca      660

tctgcatcgc cctccttgtg gtcggcatca tgtgtgtggt ggcctactgc aaaaccaaga      720

aacagcggaa aaagctgcat gaccgtcttc ggcagagcct tcggtctgaa cgaaacaata      780

tgatgaacat tgccaatggg cctcaccatc ctaacccacc ccccgagaat gtccagctgg      840

tgaatcaata cgtatctaaa aacgtcatct ccagtgagca tattgttgag agagaagcag      900

agacatcctt ttccaccagt cactatactt ccacagccca tcactccact actgtcaccc      960

agactcctag ccacagctgg agcaacggac acactgaaag catcctttcc gaaagccact     1020

ctgtaatcgt gatgtcatcc gtagaaaaca gtaggcacag cagcccaact gggggcccaa     1080

gaggacgtct taatggcaca ggaggccctc gtgaatgtaa cagcttcctc aggcatgcca     1140

gagaaacccc tgattcctac cgagactctc ctcatagtga aaggtatgtg tcagccatga     1200

ccaccccggc tcgtatgtca cctgtagatt tccacacgcc aagctccccc aaatcgcccc     1260

cttcggaaat gtctccaccc gtgtccagca tgacggtgtc catgccttcc atggcggtca     1320

gccccttcat ggaagaagag agacctctac ttctcgtgac accaccaagg ctgcgggaga     1380

agaagtttga ccatcaccct cagcagttca gctccttcca ccacaacccc gcgcatgaca     1440

gtaacagcct ccctgctagc cccttgagga tagtggagga tgaggagtat gaaacgaccc     1500

aagagtacga gccagcccaa gagcctgtta agaaactcgc caatagccgg cgggccaaaa     1560

gaaccaagcc caatggccac attgctaaca gattggaagt ggacagcaac acaagctccc     1620

agagcagtaa ctcagagagt gaaacagaag atgaaagagt aggtgaagat acgcctttcc     1680

tgggcataca gaaccccctg gcagccagtc ttgaggcaac acctgccttc cgcctggctg     1740

acagcaggac taacccagca ggccgcttct cgacacagga agaaatccag gccaggctgt     1800

ctagtgtaat tgctaaccaa gaccctattg ctgtataaaa cctaaataaa cacatagatt     1860

cacctgtaaa actttatttt atataataaa gtattccacc ttaaattaaa caatttattt     1920

tattttagca gttctgcaaa tagaaaacag gaaaaaaact tttataaatt aaatatatgt     1980

atgtaaaaat gtgttatgtg ccatatgtag caatttttta cagtatttca aaacgagaaa     2040

gatatcaatg gtgcctttat gttatgttat gtcgagagca agttttgtac agttacagtg     2100

attgcttttc cacagtattt ctgcaaaacc tctcatagat tcagtttttg ctggcttctt     2160

gtgcattgca ttatgatgtt gactggatgt atgatttgca agacttgcaa ctgtccctct     2220

gtttgcttgt agtagcaccc gatcagtatg tcttgtaatg gcacatccat ccagatatgc     2280

ctctcttgtg tatgaagttt tctttgcttt cagaatatga aatgagttgt gtctactctg     2340

ccagccaaag gtttgcctca ttgggctctg agataatagt agatccaaca gcatgctact     2400

attaaataca gcaagaaact gcattaagta atgttaaata ttaggaagaa agtaatactg     2460

tgatttaaaa aaaactatat tattaatcag aagacagctt gctcttacta aaaggagctc     2520

tcatttactt tatttgattt tatttttctt gacaaaaagc aacagtttta gggatagctt     2580

agaaaatggg ttctggcttg ctatcagggt aaatctaaca ccttacaaga ggactgagtg     2640

tcactttctc tctgggggaa tgatccagca gcttatctag ttgacaatca aaacacggct     2700

gataaaggtg caatcatttc tgacatgtat ttttcactga ttttgaagct agtgattggt     2760

tgtgtcttct tggctcaaaa agaagcatat tacggcacaa aaagcccagc ccagacagca     2820

catgcagcat tttgtctgaa atacttctag agtcaaacgt gcctgctgta catagcgatg     2880

acttgtcatc atagggaagt atttccatcg tagagtgttc agaaggagtg actgtatagg     2940

tggagagaag cttagtgact ccgttgaaat tttaaaatgt ggatgaccac ccctttctcc     3000

cccttatttt tcttttatct ttccatgttg ccttgatcag gtcataacta tgcatgaaca     3060

ttttttatca ggaatggccg atgtgtatgt gatttgtaat cacaagtaat gattcatcag     3120

gaaatgtcaa tcctgttgga aagattgcac ctttacttgc agaagtgacc cccacctgtg     3180

tcctgacctc tccatttaca ggctctctca cccatttccc ccacctcctt taatttttgc     3240

tttactgtca taaagtagga ctaagattgg tctaagcatt gcatgttctt ttgtgatggt     3300

aaatccaaag gaaggcctat aagtattaac atttgaaata actgctaatt caggaaaatg     3360

gaagaaaaaa aattatttga aacacagaac ccatttcatg gcctgcctga tatctgtgaa     3420

atcagggctg gagctttact taggattcac atggcctcct aggaaccatg ggacaaatgg     3480

gaaacaggtt atcgggggat tcatgaagtc agtgagagta attgcttctt ttttgcgggt     3540

gaactgaatg tatttcttca ccaaatcttg atgttaacaa ttaaaaagaa gaaatgacat     3600

gcaagtaggt cttagcagaa aaatgcaggc tgggcatgag tcatgttgtt accctcccac     3660

atgctcctac aatccacaga gatgcctgtc tgcaggttct tgaagttatt gttagtattt     3720

ggtatctcaa atttttcgtc actgttcaca tgccactttc tctgtgcaca gtggtatcct     3780

catttgcttt ttaacctaca ctgaggagtc tttgtcaggt tgcactgatt ttccaattct     3840

gcagtaatga gtaagctcac ggcatgggga agaagacagt cagtccaatg aagttctcta     3900

aattatttta acattgcctt tgaaggcctt gactcatcct tagctatttc aatgaagaaa     3960

ttcctaccat gaatttaaaa ccctaaaaat tctgtttcaa attctttggg cattggggta     4020

ctcagatatc ccattgtgga agaattttaa gaataaatag aagtttctgt tgagaaccat     4080

gagcaacatg tttcttacaa tgagaattgc tatgcatttt aaaattgcaa atatatatga     4140

aaattgaaga caagaggaaa ttgtatttct aacttgattc tgatcactca cagaggtggc     4200

atattattat agttgggaca tcctttgcac ccttcataaa aaaggccagc tgactgctca     4260

gcatcacctg ccaaggccac tagatttgtg tttacagggg tatctctgtg atgcttgtca     4320

catcactctt gaccacctct gttaataaat tccgacagtg cagtggcgat cggagtgtga     4380

acttatgttc ccagcatatg gaaagctatc ttaggtttta aggtagtaga aattgcccag     4440

gagtttgaca gcaactttgt ttcccgggtc taaaatcgta tcccactgag gtgtatgcag     4500

tggagcataa tacatgcaaa tacatgcaaa actccttttg tttcacctaa gattcacttt     4560

ctatcttact ttcccttcct gcctagtgtg acttttgccc ccaagagtgc ctggacagca     4620

ttctagtttc tacaaaatgg tcctctgtgt aggtgaatgt gtcccaaacc tgctatcact     4680

ttcttgtttc agtgtgactg tcttgttaga ggtgaagttt atccagggta acttgctcac     4740

taactattcc tttttatggc ctggggttaa agggcgcatg gctcacactg gtgaaaataa     4800

ggaaggcctg gtcttatctt gtattaataa tactggctgc attccaccag ccagagattt     4860

ctatctgcga agacctatga aacactgaag agaaatgtag gcagaaggaa atggccacat     4920

atcacaagtt ctattatata ttcttttgta aatacatatt gtatattact tggatgtttt     4980

cttatatcat ttactgtctt tttgagttaa tgtcagtttt tactctctca acttactatg     5040

taacattgta aataacataa tgtcctttat tatttatatt taagcatcta acatatagag     5100

ttgttttcat ataagtttaa gataaatgtc aaaaatatat gttcttttgt ttttctttgc     5160

tttaaaatta tgtatctttt ccttttcttt tttttaagaa taatttattg ttcaggagaa     5220

agaatgtata tgtaactgaa actatctgaa gaatgcacat tgaaggccgt gaggtactga     5280

taaactaaag aatttattat tcaaaatact aagcaataag taattgtgat ttatttaaag     5340

ttttgtccat tttccatgaa agacatactg caataaaaat gctactctgt ggagacctgg     5400

gagtgttgct cagcagacta cagcttcagt ctgttagacc agcacctttc atctcattcc     5460

catagttatg ctaatttagg attgtgttcc atggacccca tgatcacctt gtctatacgt     5520

tgcttcttgt ctgtccattg cttttgccac accacctgtt ctcaaatcat ctcctcccta     5580

ccaatgctgt ttatcacttt cttccttgtt gaagaggcca cacaaccaga cagtactatg     5640

cttccttttt cctccataca caataacaga gagagaatat tctagggcat gactgcctgg     5700

atcctggctg ttgctatctt ttgtagtggc agtaagaaac tccttcagac taatgaaaat     5760

gtcaacgtgc cattcaatca cgaaaggtaa cgaaaaatgc tctcatggtt caaatagtcc     5820

aatggcccat agtggcctaa aaggcagcca gttgacacct ggccatgcta agcttcctta     5880

taccatccgc taatgacttt ccattgggcc cacaatttac ggattcataa ttttaaaaga     5940

ggagaaggcc aagttaggtt cattcccctt attctgtcaa taaaacaaat caaactcatg     6000

tctatctaac tgctcaggga ggagcctttg catgagaaaa ttctcatatt ctaagactga     6060

gtcatagaaa tgagggtatt acttttctta ctgcaattaa cctaaacaaa agccatattt     6120

taacaaatag atatttgcat ggtacccttc atatattcca agcatttcac tcattattcc     6180

aggtaggtta agagcttctg aagtgtatga agtaaaggtc agcaatcctt tggggtgaac     6240

agtggcctcc tttggagttt gggggtaacc tgagacttcc caccaatgtc cacctccatc     6300

tgtgtaccta attcctatta cctagttatg gctcctctag gatcatttcc aaacactctg     6360

gatgtccagg aaatttaaat tgtagctttt gactgagcta gtttttccta tttatattaa     6420

taaattttca aaaatgcttg aaatcttcac atttgcaaca actttagttt tcatgcacat     6480

acaaacacag agagacaaaa attccaaaca gacactctcc aaaagccacc acactctttc     6540

acttgctcta tagtcattta gccaaccagc catgcagaga atatttaaaa cttaaagatt     6600

gagacattat tctcagtttt tgctgaggct ttgtaacgaa attgaacact ataagcagct     6660

attgtagtaa ttttggttaa aattgtttgc ctgggatata gtatttgagg cagaagcacg     6720

tgtgtgaagg aggtgaggtg gtttggaaag agtgaagact cgcagccaga ttgaatgtct     6780

ggataattac tataattctc ccttcttggt tgaaaccatg ttctctcttg atttttaaac     6840

ccaggctgcc tctggaaaca agcaaacctg agtctttcta acctgagtct tcccaatcat     6900

tagatttctt ttctgtccta acgatgaatg ataaaaggac ttgatgttca caatttgggg     6960

ttataaggca ggtctgaaat ctggagactc aagatgctgg aaggagtgga aagtttcgat     7020

gactttatat gaatcacttt gcactctatg tttggcttgt cctctttgaa actgatttac     7080

taaaataaat gtaagggaac tattactcca aaagattaac ttggcaggaa ataccaatac     7140

tttcagttta tgaaagacaa aactgtcttg ttgctacagg aagctgcaat gttcctaacc     7200

tttaaggttg gtgttgaata gggtggtcat gccctcccct gcaggtatct ttaggctcct     7260

gttgacctcc tggtactata actgttcgtc ttctctgggt agctattgat tttgaacttt     7320

aacatgcttc aaaactttat tcatcaggga aataggaaaa gagttttgtt acctggagga     7380

aatctattgt gatctacctg agctttttaa aaacagacca ggagaaggaa accagtaatt     7440

tttaaagaag agacagagaa tgggataata gtttcaccca ggatctcttt ctaacccttt     7500

cccttcaaat gaacttattg gaacagaatt ggaaagaaga aaggacatct ctgcccaccc     7560

cacaggatgc caaaaaggct aaagaattac ctctgtagat ttaaacatct ttaatggctt     7620

atgtatagat ttgctaatac agagagaaat gaactattaa ataaaaatca cattttataa     7680

tatttttatg gcttaaaaca tcctttatct cctttttgtt ctctctacat gatatggtaa     7740

gtgatgagga aaatttaggc tcaggaaggt taaaatcttt cttggagtta cacatctaag     7800

agagctgcag agctgacact tgtacccagg ttttctgact gcaaatccag tttctttcta     7860

ttgcgttctt cccctttccc tgcctcaagc agaaacaggt tttttatttt caacctttat     7920

gtatacagta tgttatgtta catctacagc taagtttctt tttagaagaa tgtgagccct     7980

tctagctttg gtttagagtg attctagaag ccaatttcct tggcttagtg attctatgca     8040

cctttcctaa acttagcttt ctaaggaaat gaagtgtacg agtgagaatg aattcacaat     8100

ttcgacatgt aggtagcatc ctaaagtgaa aagaggagga aatttgtggt caaagcactc     8160

tccccaccac ttagaaactt actgactgtg ggcagcttcc tcctccaagt ttccttcctg     8220

atttacaaga ccgtggtgtg gtcaggatta aacttgaata catgtaagga agcctgaaag     8280

tgtctaacac atagcgagta ttcaaatgcc accttctatt tgatccttcc cctccagttc     8340

cttaagtttt ggaatctagg tttctcagtt ccaaatggat tgacatttgc atatccccat     8400

tgcacaatgg atcaaataaa ctttatgtta tcatttctcc aacatagtgc cagtaagcaa     8460

atccttttta ataacaacag tatgttgaga aacatatcac caaataatat ttaactttgt     8520

agctttgata agttctttag gttttggttt tggttttgtt ttctgagaca gggtcttgat     8580

ctgtcaccca gactggagtg caatggttca attttagctc actgcaacct gtaactcctg     8640

agctcaagtg atcctcccac ctcagcctct caagtagctg ggactacagg tgtgctccac     8700

catgcccagc gatttttttt tttttttttt tttttttttt tggtagggac aaggtctcgc     8760

tatgttgccc aggctggtct tcaattcctg gccttaagtg atcctcctgc ctcggcctcc     8820

caaagtgctg gaattacagg catgagccac cacccataac tttatgtttg tttttttgat     8880

gcagtataag ttcagcttgc ttcttatgca gccataccat ttcatgttaa ctctgatttt     8940

tagcagctta ttacattagt gttttattat taatataatt ttacagaaat ttactaaacc     9000

atgactctgt agagttttaa taatactacc tccaaacatc attgcaaaca tctagaagaa     9060

tgaacaaaaa tgatcttaga tcgacagtat atctgtttgt cttagtttct acacaggatg     9120

ttcagacata ttccatttct ttaaaaaaaa aatatatata tatatatata tatataggcc     9180

tggcacggtg gctcatgact gtaatcccag cactttggga ggcttaggca ggcaaatcac     9240

ctgaggtcag gagtttgaga ctggcctgac caacatggtg aaacctcgtc tctattaaaa     9300

ttacaaaaat tagccgggcg tggtggcaca tgcctgtaat cccagctact cgggaggctg     9360

aggcaggaga atcacttgaa cctgggaggc agaggttgca gtgagttgag atcacgccat     9420

tgcactccag ccttggtgac aagagtgaaa ctccgtctca aaaaaaaaaa aaatatgtat     9480

atatatatat atatatatat atatatatat atatatatat atataaaatc ccaccaaaag     9540

tctgcagagt gaccaaatta gacggctctg gtttcagatt aaattctaaa tgtgagaaac     9600

cacatagctc ccatgatcca tccaataatt cctcacgtcc tcttcactct ttactccatg     9660

cataaaacag aatttttttt tctcatcctg ggtatgaagc aattaataat ttacggattt     9720

agcctatttg gattcaatcc cttcaaactc catactacat ccaaggtgga agtgacttaa     9780

actctgatat caatcatcag gcttgtaata taggctttgt taatggcagg agagtctaat     9840

aaaactttct gttccttatc cttcatttaa atgaaaaact ttttattgaa aacaatcata     9900

actctagctc atcataaata taattcatga ggacatttta ttatttttat attaaagaaa     9960

taatattata gatgtaaact ttgcaccttt ctaattatta tcatgagtta agctaatact    10020

tgtcttctgg tccctagatg atgattcttt tttgccttac tggaggagcc cttgtcttga    10080

agtgagttgc ttcaacagca gaggacttct agtttctccc agttgagcct aaagtgaact    10140

tttcatcttc ttcagaggaa ggggcttcct tgatttgtac ttttgtggct cctcagataa    10200

cacagacaat tttatcttgg atcccaggtt ctcttcacca ttaagaataa gaaagagaga    10260

aaatgctgtg catgacagcc acctactcca aactacccaa ccccctgtaa ccaggtacct    10320

tccaacaacg agatgattct gccctcactc aagagtctcc cccacaaaga ttccattctc    10380

cctttacttt ttatttttta tttttttgca aaacaaaggc ctcctttagt acctccttag    10440

tttataaccc ttatcttccc agctcttccc ttcactgata cctctgattt caaaagttct    10500

gaagtcggaa gaccacacaa tttcagactg tgaacagaaa ttcagtcaga aattattgga    10560

gttagaaaga atttagagaa attgtattga actagaaagt cctctttgat tagtggtggc    10620

cctttagaaa gttctagggc agagtcccat ggtgtttcat cttttccatg atttgcttga    10680

ccaaaaactt ttctttcaca acatgaaaat atgctaatcc accacacatt ttggattctg    10740

ctctgtttgc ctgaggtgtt agatctctag ccaggactgt gaagggaagg aacttgaatc    10800

cttcctattg agctattaat gcagagtcag tgagatgaag ggttccactc ggggtcaaaa    10860

tcatgtcagt taccaagcaa aggagcaagt aaggggaaac atctcctcat ctggttagtg    10920

gagccacatt tcacccactg atcaagccag acctgagcaa tagtctagat ttctccctcc    10980

acatctaatt ggtgacaatg gtgattgtac cactgacagg tcacacaagt ccacaccctc    11040

cttcacagcc tcactgcttc ggctcttgtt tatgctctta tcagcatctg tcactaggat    11100

ccatttgtct cctgactcat ctacttcctt tcactcccct gggccatcct tcacatcatg    11160

ctagaagact gtgtctaact tgcagaactt attgtgtcaa tctcctggtt acggcccctc    11220

catggctccc cacctgacat aggaggccct tcacaatctg gcttctgtca ctcataactt    11280

gtctccagcc ttcattcttc agtctgattt tatggttttc tagttcccca atacaccaca    11340

ccagtgttta tgaaacccta gtcattggcc tacgaacttt atgattattg acatattcat    11400

gtaccacctg tattattttt tgcatagtgt ttatttttaa ttgactacat ttttaactac    11460

aataaagtaa tttcaactaa aa                                             11482


<210>  154
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  154

Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly 
1               5                   10                  15      


Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu 
            20                  25                  30          


Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys 
        35                  40                  45              


Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg 
    50                  55                  60                  


Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val 
65                  70                  75                  80  


Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val 
                85                  90                  95      


Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala 
            100                 105                 110         


Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly 
        115                 120                 125             


Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His 
    130                 135                 140                 


Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly 
145                 150                 155                 160 


Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys 
                165                 170                 175     


Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met 
            180                 185                 190         


Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu 
        195                 200                 205             


Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu 
    210                 215                 220                 


Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys 
225                 230                 235                 240 


Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu 
                245                 250                 255     


Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro Asn Pro 
            260                 265                 270         


Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val 
        275                 280                 285             


Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser 
    290                 295                 300                 


Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val Thr Gln 
305                 310                 315                 320 


Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser 
                325                 330                 335     


Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser Arg His 
            340                 345                 350         


Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly 
        355                 360                 365             


Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp 
    370                 375                 380                 


Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr 
385                 390                 395                 400 


Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro 
                405                 410                 415     


Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met Thr Val 
            420                 425                 430         


Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro 
        435                 440                 445             


Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His 
    450                 455                 460                 


His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His Asp Ser 
465                 470                 475                 480 


Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr 
                485                 490                 495     


Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu 
            500                 505                 510         


Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala 
        515                 520                 525             


Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser 
    530                 535                 540                 


Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu 
545                 550                 555                 560 


Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe 
                565                 570                 575     


Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln 
            580                 585                 590         


Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro 
        595                 600                 605             


Ile Ala Val 
    610     


<210>  155
<211>  11080
<212>  DNA
<213>  Homo sapiens

<400>  155
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgcttca tggtgaaaga cctttcaaac ccctcgagat      120

acttgtgcaa gtgcccaaat gagtttactg gtgatcgctg ccaaaactac gtaatggcca      180

gcttctacaa gcatcttggg attgaattta tggaggcgga ggagctgtac cagaagagag      240

tgctgaccat aaccggcatc tgcatcgccc tccttgtggt cggcatcatg tgtgtggtgg      300

cctactgcaa aaccaagaaa cagcggaaaa agctgcatga ccgtcttcgg cagagccttc      360

ggtctgaacg aaacaatatg atgaacattg ccaatgggcc tcaccatcct aacccacccc      420

ccgagaatgt ccagctggtg aatcaatacg tatctaaaaa cgtcatctcc agtgagcata      480

ttgttgagag agaagcagag acatcctttt ccaccagtca ctatacttcc acagcccatc      540

actccactac tgtcacccag actcctagcc acagctggag caacggacac actgaaagca      600

tcctttccga aagccactct gtaatcgtga tgtcatccgt agaaaacagt aggcacagca      660

gcccaactgg gggcccaaga ggacgtctta atggcacagg aggccctcgt gaatgtaaca      720

gcttcctcag gcatgccaga gaaacccctg attcctaccg agactctcct catagtgaaa      780

ggtatgtgtc agccatgacc accccggctc gtatgtcacc tgtagatttc cacacgccaa      840

gctcccccaa atcgccccct tcggaaatgt ctccacccgt gtccagcatg acggtgtcca      900

tgccttccat ggcggtcagc cccttcatgg aagaagagag acctctactt ctcgtgacac      960

caccaaggct gcgggagaag aagtttgacc atcaccctca gcagttcagc tccttccacc     1020

acaaccccgc gcatgacagt aacagcctcc ctgctagccc cttgaggata gtggaggatg     1080

aggagtatga aacgacccaa gagtacgagc cagcccaaga gcctgttaag aaactcgcca     1140

atagccggcg ggccaaaaga accaagccca atggccacat tgctaacaga ttggaagtgg     1200

acagcaacac aagctcccag agcagtaact cagagagtga aacagaagat gaaagagtag     1260

gtgaagatac gcctttcctg ggcatacaga accccctggc agccagtctt gaggcaacac     1320

ctgccttccg cctggctgac agcaggacta acccagcagg ccgcttctcg acacaggaag     1380

aaatccaggc caggctgtct agtgtaattg ctaaccaaga ccctattgct gtataaaacc     1440

taaataaaca catagattca cctgtaaaac tttattttat ataataaagt attccacctt     1500

aaattaaaca atttatttta ttttagcagt tctgcaaata gaaaacagga aaaaaacttt     1560

tataaattaa atatatgtat gtaaaaatgt gttatgtgcc atatgtagca attttttaca     1620

gtatttcaaa acgagaaaga tatcaatggt gcctttatgt tatgttatgt cgagagcaag     1680

ttttgtacag ttacagtgat tgcttttcca cagtatttct gcaaaacctc tcatagattc     1740

agtttttgct ggcttcttgt gcattgcatt atgatgttga ctggatgtat gatttgcaag     1800

acttgcaact gtccctctgt ttgcttgtag tagcacccga tcagtatgtc ttgtaatggc     1860

acatccatcc agatatgcct ctcttgtgta tgaagttttc tttgctttca gaatatgaaa     1920

tgagttgtgt ctactctgcc agccaaaggt ttgcctcatt gggctctgag ataatagtag     1980

atccaacagc atgctactat taaatacagc aagaaactgc attaagtaat gttaaatatt     2040

aggaagaaag taatactgtg atttaaaaaa aactatatta ttaatcagaa gacagcttgc     2100

tcttactaaa aggagctctc atttacttta tttgatttta tttttcttga caaaaagcaa     2160

cagttttagg gatagcttag aaaatgggtt ctggcttgct atcagggtaa atctaacacc     2220

ttacaagagg actgagtgtc actttctctc tgggggaatg atccagcagc ttatctagtt     2280

gacaatcaaa acacggctga taaaggtgca atcatttctg acatgtattt ttcactgatt     2340

ttgaagctag tgattggttg tgtcttcttg gctcaaaaag aagcatatta cggcacaaaa     2400

agcccagccc agacagcaca tgcagcattt tgtctgaaat acttctagag tcaaacgtgc     2460

ctgctgtaca tagcgatgac ttgtcatcat agggaagtat ttccatcgta gagtgttcag     2520

aaggagtgac tgtataggtg gagagaagct tagtgactcc gttgaaattt taaaatgtgg     2580

atgaccaccc ctttctcccc cttatttttc ttttatcttt ccatgttgcc ttgatcaggt     2640

cataactatg catgaacatt ttttatcagg aatggccgat gtgtatgtga tttgtaatca     2700

caagtaatga ttcatcagga aatgtcaatc ctgttggaaa gattgcacct ttacttgcag     2760

aagtgacccc cacctgtgtc ctgacctctc catttacagg ctctctcacc catttccccc     2820

acctccttta atttttgctt tactgtcata aagtaggact aagattggtc taagcattgc     2880

atgttctttt gtgatggtaa atccaaagga aggcctataa gtattaacat ttgaaataac     2940

tgctaattca ggaaaatgga agaaaaaaaa ttatttgaaa cacagaaccc atttcatggc     3000

ctgcctgata tctgtgaaat cagggctgga gctttactta ggattcacat ggcctcctag     3060

gaaccatggg acaaatggga aacaggttat cgggggattc atgaagtcag tgagagtaat     3120

tgcttctttt ttgcgggtga actgaatgta tttcttcacc aaatcttgat gttaacaatt     3180

aaaaagaaga aatgacatgc aagtaggtct tagcagaaaa atgcaggctg ggcatgagtc     3240

atgttgttac cctcccacat gctcctacaa tccacagaga tgcctgtctg caggttcttg     3300

aagttattgt tagtatttgg tatctcaaat ttttcgtcac tgttcacatg ccactttctc     3360

tgtgcacagt ggtatcctca tttgcttttt aacctacact gaggagtctt tgtcaggttg     3420

cactgatttt ccaattctgc agtaatgagt aagctcacgg catggggaag aagacagtca     3480

gtccaatgaa gttctctaaa ttattttaac attgcctttg aaggccttga ctcatcctta     3540

gctatttcaa tgaagaaatt cctaccatga atttaaaacc ctaaaaattc tgtttcaaat     3600

tctttgggca ttggggtact cagatatccc attgtggaag aattttaaga ataaatagaa     3660

gtttctgttg agaaccatga gcaacatgtt tcttacaatg agaattgcta tgcattttaa     3720

aattgcaaat atatatgaaa attgaagaca agaggaaatt gtatttctaa cttgattctg     3780

atcactcaca gaggtggcat attattatag ttgggacatc ctttgcaccc ttcataaaaa     3840

aggccagctg actgctcagc atcacctgcc aaggccacta gatttgtgtt tacaggggta     3900

tctctgtgat gcttgtcaca tcactcttga ccacctctgt taataaattc cgacagtgca     3960

gtggcgatcg gagtgtgaac ttatgttccc agcatatgga aagctatctt aggttttaag     4020

gtagtagaaa ttgcccagga gtttgacagc aactttgttt cccgggtcta aaatcgtatc     4080

ccactgaggt gtatgcagtg gagcataata catgcaaata catgcaaaac tccttttgtt     4140

tcacctaaga ttcactttct atcttacttt cccttcctgc ctagtgtgac ttttgccccc     4200

aagagtgcct ggacagcatt ctagtttcta caaaatggtc ctctgtgtag gtgaatgtgt     4260

cccaaacctg ctatcacttt cttgtttcag tgtgactgtc ttgttagagg tgaagtttat     4320

ccagggtaac ttgctcacta actattcctt tttatggcct ggggttaaag ggcgcatggc     4380

tcacactggt gaaaataagg aaggcctggt cttatcttgt attaataata ctggctgcat     4440

tccaccagcc agagatttct atctgcgaag acctatgaaa cactgaagag aaatgtaggc     4500

agaaggaaat ggccacatat cacaagttct attatatatt cttttgtaaa tacatattgt     4560

atattacttg gatgttttct tatatcattt actgtctttt tgagttaatg tcagttttta     4620

ctctctcaac ttactatgta acattgtaaa taacataatg tcctttatta tttatattta     4680

agcatctaac atatagagtt gttttcatat aagtttaaga taaatgtcaa aaatatatgt     4740

tcttttgttt ttctttgctt taaaattatg tatcttttcc ttttcttttt tttaagaata     4800

atttattgtt caggagaaag aatgtatatg taactgaaac tatctgaaga atgcacattg     4860

aaggccgtga ggtactgata aactaaagaa tttattattc aaaatactaa gcaataagta     4920

attgtgattt atttaaagtt ttgtccattt tccatgaaag acatactgca ataaaaatgc     4980

tactctgtgg agacctggga gtgttgctca gcagactaca gcttcagtct gttagaccag     5040

cacctttcat ctcattccca tagttatgct aatttaggat tgtgttccat ggaccccatg     5100

atcaccttgt ctatacgttg cttcttgtct gtccattgct tttgccacac cacctgttct     5160

caaatcatct cctccctacc aatgctgttt atcactttct tccttgttga agaggccaca     5220

caaccagaca gtactatgct tcctttttcc tccatacaca ataacagaga gagaatattc     5280

tagggcatga ctgcctggat cctggctgtt gctatctttt gtagtggcag taagaaactc     5340

cttcagacta atgaaaatgt caacgtgcca ttcaatcacg aaaggtaacg aaaaatgctc     5400

tcatggttca aatagtccaa tggcccatag tggcctaaaa ggcagccagt tgacacctgg     5460

ccatgctaag cttccttata ccatccgcta atgactttcc attgggccca caatttacgg     5520

attcataatt ttaaaagagg agaaggccaa gttaggttca ttccccttat tctgtcaata     5580

aaacaaatca aactcatgtc tatctaactg ctcagggagg agcctttgca tgagaaaatt     5640

ctcatattct aagactgagt catagaaatg agggtattac ttttcttact gcaattaacc     5700

taaacaaaag ccatatttta acaaatagat atttgcatgg tacccttcat atattccaag     5760

catttcactc attattccag gtaggttaag agcttctgaa gtgtatgaag taaaggtcag     5820

caatcctttg gggtgaacag tggcctcctt tggagtttgg gggtaacctg agacttccca     5880

ccaatgtcca cctccatctg tgtacctaat tcctattacc tagttatggc tcctctagga     5940

tcatttccaa acactctgga tgtccaggaa atttaaattg tagcttttga ctgagctagt     6000

ttttcctatt tatattaata aattttcaaa aatgcttgaa atcttcacat ttgcaacaac     6060

tttagttttc atgcacatac aaacacagag agacaaaaat tccaaacaga cactctccaa     6120

aagccaccac actctttcac ttgctctata gtcatttagc caaccagcca tgcagagaat     6180

atttaaaact taaagattga gacattattc tcagtttttg ctgaggcttt gtaacgaaat     6240

tgaacactat aagcagctat tgtagtaatt ttggttaaaa ttgtttgcct gggatatagt     6300

atttgaggca gaagcacgtg tgtgaaggag gtgaggtggt ttggaaagag tgaagactcg     6360

cagccagatt gaatgtctgg ataattacta taattctccc ttcttggttg aaaccatgtt     6420

ctctcttgat ttttaaaccc aggctgcctc tggaaacaag caaacctgag tctttctaac     6480

ctgagtcttc ccaatcatta gatttctttt ctgtcctaac gatgaatgat aaaaggactt     6540

gatgttcaca atttggggtt ataaggcagg tctgaaatct ggagactcaa gatgctggaa     6600

ggagtggaaa gtttcgatga ctttatatga atcactttgc actctatgtt tggcttgtcc     6660

tctttgaaac tgatttacta aaataaatgt aagggaacta ttactccaaa agattaactt     6720

ggcaggaaat accaatactt tcagtttatg aaagacaaaa ctgtcttgtt gctacaggaa     6780

gctgcaatgt tcctaacctt taaggttggt gttgaatagg gtggtcatgc cctcccctgc     6840

aggtatcttt aggctcctgt tgacctcctg gtactataac tgttcgtctt ctctgggtag     6900

ctattgattt tgaactttaa catgcttcaa aactttattc atcagggaaa taggaaaaga     6960

gttttgttac ctggaggaaa tctattgtga tctacctgag ctttttaaaa acagaccagg     7020

agaaggaaac cagtaatttt taaagaagag acagagaatg ggataatagt ttcacccagg     7080

atctctttct aaccctttcc cttcaaatga acttattgga acagaattgg aaagaagaaa     7140

ggacatctct gcccacccca caggatgcca aaaaggctaa agaattacct ctgtagattt     7200

aaacatcttt aatggcttat gtatagattt gctaatacag agagaaatga actattaaat     7260

aaaaatcaca ttttataata tttttatggc ttaaaacatc ctttatctcc tttttgttct     7320

ctctacatga tatggtaagt gatgaggaaa atttaggctc aggaaggtta aaatctttct     7380

tggagttaca catctaagag agctgcagag ctgacacttg tacccaggtt ttctgactgc     7440

aaatccagtt tctttctatt gcgttcttcc cctttccctg cctcaagcag aaacaggttt     7500

tttattttca acctttatgt atacagtatg ttatgttaca tctacagcta agtttctttt     7560

tagaagaatg tgagcccttc tagctttggt ttagagtgat tctagaagcc aatttccttg     7620

gcttagtgat tctatgcacc tttcctaaac ttagctttct aaggaaatga agtgtacgag     7680

tgagaatgaa ttcacaattt cgacatgtag gtagcatcct aaagtgaaaa gaggaggaaa     7740

tttgtggtca aagcactctc cccaccactt agaaacttac tgactgtggg cagcttcctc     7800

ctccaagttt ccttcctgat ttacaagacc gtggtgtggt caggattaaa cttgaataca     7860

tgtaaggaag cctgaaagtg tctaacacat agcgagtatt caaatgccac cttctatttg     7920

atccttcccc tccagttcct taagttttgg aatctaggtt tctcagttcc aaatggattg     7980

acatttgcat atccccattg cacaatggat caaataaact ttatgttatc atttctccaa     8040

catagtgcca gtaagcaaat cctttttaat aacaacagta tgttgagaaa catatcacca     8100

aataatattt aactttgtag ctttgataag ttctttaggt tttggttttg gttttgtttt     8160

ctgagacagg gtcttgatct gtcacccaga ctggagtgca atggttcaat tttagctcac     8220

tgcaacctgt aactcctgag ctcaagtgat cctcccacct cagcctctca agtagctggg     8280

actacaggtg tgctccacca tgcccagcga tttttttttt tttttttttt tttttttttg     8340

gtagggacaa ggtctcgcta tgttgcccag gctggtcttc aattcctggc cttaagtgat     8400

cctcctgcct cggcctccca aagtgctgga attacaggca tgagccacca cccataactt     8460

tatgtttgtt tttttgatgc agtataagtt cagcttgctt cttatgcagc cataccattt     8520

catgttaact ctgattttta gcagcttatt acattagtgt tttattatta atataatttt     8580

acagaaattt actaaaccat gactctgtag agttttaata atactacctc caaacatcat     8640

tgcaaacatc tagaagaatg aacaaaaatg atcttagatc gacagtatat ctgtttgtct     8700

tagtttctac acaggatgtt cagacatatt ccatttcttt aaaaaaaaaa tatatatata     8760

tatatatata tataggcctg gcacggtggc tcatgactgt aatcccagca ctttgggagg     8820

cttaggcagg caaatcacct gaggtcagga gtttgagact ggcctgacca acatggtgaa     8880

acctcgtctc tattaaaatt acaaaaatta gccgggcgtg gtggcacatg cctgtaatcc     8940

cagctactcg ggaggctgag gcaggagaat cacttgaacc tgggaggcag aggttgcagt     9000

gagttgagat cacgccattg cactccagcc ttggtgacaa gagtgaaact ccgtctcaaa     9060

aaaaaaaaaa atatgtatat atatatatat atatatatat atatatatat atatatatat     9120

ataaaatccc accaaaagtc tgcagagtga ccaaattaga cggctctggt ttcagattaa     9180

attctaaatg tgagaaacca catagctccc atgatccatc caataattcc tcacgtcctc     9240

ttcactcttt actccatgca taaaacagaa tttttttttc tcatcctggg tatgaagcaa     9300

ttaataattt acggatttag cctatttgga ttcaatccct tcaaactcca tactacatcc     9360

aaggtggaag tgacttaaac tctgatatca atcatcaggc ttgtaatata ggctttgtta     9420

atggcaggag agtctaataa aactttctgt tccttatcct tcatttaaat gaaaaacttt     9480

ttattgaaaa caatcataac tctagctcat cataaatata attcatgagg acattttatt     9540

atttttatat taaagaaata atattataga tgtaaacttt gcacctttct aattattatc     9600

atgagttaag ctaatacttg tcttctggtc cctagatgat gattcttttt tgccttactg     9660

gaggagccct tgtcttgaag tgagttgctt caacagcaga ggacttctag tttctcccag     9720

ttgagcctaa agtgaacttt tcatcttctt cagaggaagg ggcttccttg atttgtactt     9780

ttgtggctcc tcagataaca cagacaattt tatcttggat cccaggttct cttcaccatt     9840

aagaataaga aagagagaaa atgctgtgca tgacagccac ctactccaaa ctacccaacc     9900

ccctgtaacc aggtaccttc caacaacgag atgattctgc cctcactcaa gagtctcccc     9960

cacaaagatt ccattctccc tttacttttt attttttatt tttttgcaaa acaaaggcct    10020

cctttagtac ctccttagtt tataaccctt atcttcccag ctcttccctt cactgatacc    10080

tctgatttca aaagttctga agtcggaaga ccacacaatt tcagactgtg aacagaaatt    10140

cagtcagaaa ttattggagt tagaaagaat ttagagaaat tgtattgaac tagaaagtcc    10200

tctttgatta gtggtggccc tttagaaagt tctagggcag agtcccatgg tgtttcatct    10260

tttccatgat ttgcttgacc aaaaactttt ctttcacaac atgaaaatat gctaatccac    10320

cacacatttt ggattctgct ctgtttgcct gaggtgttag atctctagcc aggactgtga    10380

agggaaggaa cttgaatcct tcctattgag ctattaatgc agagtcagtg agatgaaggg    10440

ttccactcgg ggtcaaaatc atgtcagtta ccaagcaaag gagcaagtaa ggggaaacat    10500

ctcctcatct ggttagtgga gccacatttc acccactgat caagccagac ctgagcaata    10560

gtctagattt ctccctccac atctaattgg tgacaatggt gattgtacca ctgacaggtc    10620

acacaagtcc acaccctcct tcacagcctc actgcttcgg ctcttgttta tgctcttatc    10680

agcatctgtc actaggatcc atttgtctcc tgactcatct acttcctttc actcccctgg    10740

gccatccttc acatcatgct agaagactgt gtctaacttg cagaacttat tgtgtcaatc    10800

tcctggttac ggcccctcca tggctcccca cctgacatag gaggcccttc acaatctggc    10860

ttctgtcact cataacttgt ctccagcctt cattcttcag tctgatttta tggttttcta    10920

gttccccaat acaccacacc agtgtttatg aaaccctagt cattggccta cgaactttat    10980

gattattgac atattcatgt accacctgta ttattttttg catagtgttt atttttaatt    11040

gactacattt ttaactacaa taaagtaatt tcaactaaaa                          11080


<210>  156
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  156

Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu 
1               5                   10                  15      


Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys 
            20                  25                  30          


Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe 
        35                  40                  45              


Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys His 
    50                  55                  60                  


Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg Val 
65                  70                  75                  80  


Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile Met 
                85                  90                  95      


Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu His 
            100                 105                 110         


Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met Asn 
        115                 120                 125             


Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val Gln 
    130                 135                 140                 


Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His Ile 
145                 150                 155                 160 


Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr Ser 
                165                 170                 175     


Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser Trp 
            180                 185                 190         


Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val Ile 
        195                 200                 205             


Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly Gly 
    210                 215                 220                 


Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn Ser 
225                 230                 235                 240 


Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser Pro 
                245                 250                 255     


His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met Ser 
            260                 265                 270         


Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser Glu 
        275                 280                 285             


Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met Ala 
    290                 295                 300                 


Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr Pro 
305                 310                 315                 320 


Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe Ser 
                325                 330                 335     


Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala Ser 
            340                 345                 350         


Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu Tyr 
        355                 360                 365             


Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg Ala 
    370                 375                 380                 


Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val Asp 
385                 390                 395                 400 


Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu Asp 
                405                 410                 415     


Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro Leu 
            420                 425                 430         


Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser Arg 
        435                 440                 445             


Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala Arg 
    450                 455                 460                 


Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
465                 470                 475         


<210>  157
<211>  11083
<212>  DNA
<213>  Homo sapiens

<400>  157
catctacatc tacatccacc actgggacaa gccatcttgt aaaatgtgcg gagaaggaga       60

aaactttctg tgtgaatgga ggggagtgct tcatggtgaa agacctttca aacccctcga      120

gatacttgtg caagtgccca aatgagttta ctggtgatcg ctgccaaaac tacgtaatgg      180

ccagcttcta caagcatctt gggattgaat ttatggaggc ggaggagctg taccagaaga      240

gagtgctgac cataaccggc atctgcatcg ccctccttgt ggtcggcatc atgtgtgtgg      300

tggcctactg caaaaccaag aaacagcgga aaaagctgca tgaccgtctt cggcagagcc      360

ttcggtctga acgaaacaat atgatgaaca ttgccaatgg gcctcaccat cctaacccac      420

cccccgagaa tgtccagctg gtgaatcaat acgtatctaa aaacgtcatc tccagtgagc      480

atattgttga gagagaagca gagacatcct tttccaccag tcactatact tccacagccc      540

atcactccac tactgtcacc cagactccta gccacagctg gagcaacgga cacactgaaa      600

gcatcctttc cgaaagccac tctgtaatcg tgatgtcatc cgtagaaaac agtaggcaca      660

gcagcccaac tgggggccca agaggacgtc ttaatggcac aggaggccct cgtgaatgta      720

acagcttcct caggcatgcc agagaaaccc ctgattccta ccgagactct cctcatagtg      780

aaaggtatgt gtcagccatg accaccccgg ctcgtatgtc acctgtagat ttccacacgc      840

caagctcccc caaatcgccc ccttcggaaa tgtctccacc cgtgtccagc atgacggtgt      900

ccatgccttc catggcggtc agccccttca tggaagaaga gagacctcta cttctcgtga      960

caccaccaag gctgcgggag aagaagtttg accatcaccc tcagcagttc agctccttcc     1020

accacaaccc cgcgcatgac agtaacagcc tccctgctag ccccttgagg atagtggagg     1080

atgaggagta tgaaacgacc caagagtacg agccagccca agagcctgtt aagaaactcg     1140

ccaatagccg gcgggccaaa agaaccaagc ccaatggcca cattgctaac agattggaag     1200

tggacagcaa cacaagctcc cagagcagta actcagagag tgaaacagaa gatgaaagag     1260

taggtgaaga tacgcctttc ctgggcatac agaaccccct ggcagccagt cttgaggcaa     1320

cacctgcctt ccgcctggct gacagcagga ctaacccagc aggccgcttc tcgacacagg     1380

aagaaatcca ggccaggctg tctagtgtaa ttgctaacca agaccctatt gctgtataaa     1440

acctaaataa acacatagat tcacctgtaa aactttattt tatataataa agtattccac     1500

cttaaattaa acaatttatt ttattttagc agttctgcaa atagaaaaca ggaaaaaaac     1560

ttttataaat taaatatatg tatgtaaaaa tgtgttatgt gccatatgta gcaatttttt     1620

acagtatttc aaaacgagaa agatatcaat ggtgccttta tgttatgtta tgtcgagagc     1680

aagttttgta cagttacagt gattgctttt ccacagtatt tctgcaaaac ctctcataga     1740

ttcagttttt gctggcttct tgtgcattgc attatgatgt tgactggatg tatgatttgc     1800

aagacttgca actgtccctc tgtttgcttg tagtagcacc cgatcagtat gtcttgtaat     1860

ggcacatcca tccagatatg cctctcttgt gtatgaagtt ttctttgctt tcagaatatg     1920

aaatgagttg tgtctactct gccagccaaa ggtttgcctc attgggctct gagataatag     1980

tagatccaac agcatgctac tattaaatac agcaagaaac tgcattaagt aatgttaaat     2040

attaggaaga aagtaatact gtgatttaaa aaaaactata ttattaatca gaagacagct     2100

tgctcttact aaaaggagct ctcatttact ttatttgatt ttatttttct tgacaaaaag     2160

caacagtttt agggatagct tagaaaatgg gttctggctt gctatcaggg taaatctaac     2220

accttacaag aggactgagt gtcactttct ctctggggga atgatccagc agcttatcta     2280

gttgacaatc aaaacacggc tgataaaggt gcaatcattt ctgacatgta tttttcactg     2340

attttgaagc tagtgattgg ttgtgtcttc ttggctcaaa aagaagcata ttacggcaca     2400

aaaagcccag cccagacagc acatgcagca ttttgtctga aatacttcta gagtcaaacg     2460

tgcctgctgt acatagcgat gacttgtcat catagggaag tatttccatc gtagagtgtt     2520

cagaaggagt gactgtatag gtggagagaa gcttagtgac tccgttgaaa ttttaaaatg     2580

tggatgacca cccctttctc ccccttattt ttcttttatc tttccatgtt gccttgatca     2640

ggtcataact atgcatgaac attttttatc aggaatggcc gatgtgtatg tgatttgtaa     2700

tcacaagtaa tgattcatca ggaaatgtca atcctgttgg aaagattgca cctttacttg     2760

cagaagtgac ccccacctgt gtcctgacct ctccatttac aggctctctc acccatttcc     2820

cccacctcct ttaatttttg ctttactgtc ataaagtagg actaagattg gtctaagcat     2880

tgcatgttct tttgtgatgg taaatccaaa ggaaggccta taagtattaa catttgaaat     2940

aactgctaat tcaggaaaat ggaagaaaaa aaattatttg aaacacagaa cccatttcat     3000

ggcctgcctg atatctgtga aatcagggct ggagctttac ttaggattca catggcctcc     3060

taggaaccat gggacaaatg ggaaacaggt tatcggggga ttcatgaagt cagtgagagt     3120

aattgcttct tttttgcggg tgaactgaat gtatttcttc accaaatctt gatgttaaca     3180

attaaaaaga agaaatgaca tgcaagtagg tcttagcaga aaaatgcagg ctgggcatga     3240

gtcatgttgt taccctccca catgctccta caatccacag agatgcctgt ctgcaggttc     3300

ttgaagttat tgttagtatt tggtatctca aatttttcgt cactgttcac atgccacttt     3360

ctctgtgcac agtggtatcc tcatttgctt tttaacctac actgaggagt ctttgtcagg     3420

ttgcactgat tttccaattc tgcagtaatg agtaagctca cggcatgggg aagaagacag     3480

tcagtccaat gaagttctct aaattatttt aacattgcct ttgaaggcct tgactcatcc     3540

ttagctattt caatgaagaa attcctacca tgaatttaaa accctaaaaa ttctgtttca     3600

aattctttgg gcattggggt actcagatat cccattgtgg aagaatttta agaataaata     3660

gaagtttctg ttgagaacca tgagcaacat gtttcttaca atgagaattg ctatgcattt     3720

taaaattgca aatatatatg aaaattgaag acaagaggaa attgtatttc taacttgatt     3780

ctgatcactc acagaggtgg catattatta tagttgggac atcctttgca cccttcataa     3840

aaaaggccag ctgactgctc agcatcacct gccaaggcca ctagatttgt gtttacaggg     3900

gtatctctgt gatgcttgtc acatcactct tgaccacctc tgttaataaa ttccgacagt     3960

gcagtggcga tcggagtgtg aacttatgtt cccagcatat ggaaagctat cttaggtttt     4020

aaggtagtag aaattgccca ggagtttgac agcaactttg tttcccgggt ctaaaatcgt     4080

atcccactga ggtgtatgca gtggagcata atacatgcaa atacatgcaa aactcctttt     4140

gtttcaccta agattcactt tctatcttac tttcccttcc tgcctagtgt gacttttgcc     4200

cccaagagtg cctggacagc attctagttt ctacaaaatg gtcctctgtg taggtgaatg     4260

tgtcccaaac ctgctatcac tttcttgttt cagtgtgact gtcttgttag aggtgaagtt     4320

tatccagggt aacttgctca ctaactattc ctttttatgg cctggggtta aagggcgcat     4380

ggctcacact ggtgaaaata aggaaggcct ggtcttatct tgtattaata atactggctg     4440

cattccacca gccagagatt tctatctgcg aagacctatg aaacactgaa gagaaatgta     4500

ggcagaagga aatggccaca tatcacaagt tctattatat attcttttgt aaatacatat     4560

tgtatattac ttggatgttt tcttatatca tttactgtct ttttgagtta atgtcagttt     4620

ttactctctc aacttactat gtaacattgt aaataacata atgtccttta ttatttatat     4680

ttaagcatct aacatataga gttgttttca tataagttta agataaatgt caaaaatata     4740

tgttcttttg tttttctttg ctttaaaatt atgtatcttt tccttttctt ttttttaaga     4800

ataatttatt gttcaggaga aagaatgtat atgtaactga aactatctga agaatgcaca     4860

ttgaaggccg tgaggtactg ataaactaaa gaatttatta ttcaaaatac taagcaataa     4920

gtaattgtga tttatttaaa gttttgtcca ttttccatga aagacatact gcaataaaaa     4980

tgctactctg tggagacctg ggagtgttgc tcagcagact acagcttcag tctgttagac     5040

cagcaccttt catctcattc ccatagttat gctaatttag gattgtgttc catggacccc     5100

atgatcacct tgtctatacg ttgcttcttg tctgtccatt gcttttgcca caccacctgt     5160

tctcaaatca tctcctccct accaatgctg tttatcactt tcttccttgt tgaagaggcc     5220

acacaaccag acagtactat gcttcctttt tcctccatac acaataacag agagagaata     5280

ttctagggca tgactgcctg gatcctggct gttgctatct tttgtagtgg cagtaagaaa     5340

ctccttcaga ctaatgaaaa tgtcaacgtg ccattcaatc acgaaaggta acgaaaaatg     5400

ctctcatggt tcaaatagtc caatggccca tagtggccta aaaggcagcc agttgacacc     5460

tggccatgct aagcttcctt ataccatccg ctaatgactt tccattgggc ccacaattta     5520

cggattcata attttaaaag aggagaaggc caagttaggt tcattcccct tattctgtca     5580

ataaaacaaa tcaaactcat gtctatctaa ctgctcaggg aggagccttt gcatgagaaa     5640

attctcatat tctaagactg agtcatagaa atgagggtat tacttttctt actgcaatta     5700

acctaaacaa aagccatatt ttaacaaata gatatttgca tggtaccctt catatattcc     5760

aagcatttca ctcattattc caggtaggtt aagagcttct gaagtgtatg aagtaaaggt     5820

cagcaatcct ttggggtgaa cagtggcctc ctttggagtt tgggggtaac ctgagacttc     5880

ccaccaatgt ccacctccat ctgtgtacct aattcctatt acctagttat ggctcctcta     5940

ggatcatttc caaacactct ggatgtccag gaaatttaaa ttgtagcttt tgactgagct     6000

agtttttcct atttatatta ataaattttc aaaaatgctt gaaatcttca catttgcaac     6060

aactttagtt ttcatgcaca tacaaacaca gagagacaaa aattccaaac agacactctc     6120

caaaagccac cacactcttt cacttgctct atagtcattt agccaaccag ccatgcagag     6180

aatatttaaa acttaaagat tgagacatta ttctcagttt ttgctgaggc tttgtaacga     6240

aattgaacac tataagcagc tattgtagta attttggtta aaattgtttg cctgggatat     6300

agtatttgag gcagaagcac gtgtgtgaag gaggtgaggt ggtttggaaa gagtgaagac     6360

tcgcagccag attgaatgtc tggataatta ctataattct cccttcttgg ttgaaaccat     6420

gttctctctt gatttttaaa cccaggctgc ctctggaaac aagcaaacct gagtctttct     6480

aacctgagtc ttcccaatca ttagatttct tttctgtcct aacgatgaat gataaaagga     6540

cttgatgttc acaatttggg gttataaggc aggtctgaaa tctggagact caagatgctg     6600

gaaggagtgg aaagtttcga tgactttata tgaatcactt tgcactctat gtttggcttg     6660

tcctctttga aactgattta ctaaaataaa tgtaagggaa ctattactcc aaaagattaa     6720

cttggcagga aataccaata ctttcagttt atgaaagaca aaactgtctt gttgctacag     6780

gaagctgcaa tgttcctaac ctttaaggtt ggtgttgaat agggtggtca tgccctcccc     6840

tgcaggtatc tttaggctcc tgttgacctc ctggtactat aactgttcgt cttctctggg     6900

tagctattga ttttgaactt taacatgctt caaaacttta ttcatcaggg aaataggaaa     6960

agagttttgt tacctggagg aaatctattg tgatctacct gagcttttta aaaacagacc     7020

aggagaagga aaccagtaat ttttaaagaa gagacagaga atgggataat agtttcaccc     7080

aggatctctt tctaaccctt tcccttcaaa tgaacttatt ggaacagaat tggaaagaag     7140

aaaggacatc tctgcccacc ccacaggatg ccaaaaaggc taaagaatta cctctgtaga     7200

tttaaacatc tttaatggct tatgtataga tttgctaata cagagagaaa tgaactatta     7260

aataaaaatc acattttata atatttttat ggcttaaaac atcctttatc tcctttttgt     7320

tctctctaca tgatatggta agtgatgagg aaaatttagg ctcaggaagg ttaaaatctt     7380

tcttggagtt acacatctaa gagagctgca gagctgacac ttgtacccag gttttctgac     7440

tgcaaatcca gtttctttct attgcgttct tcccctttcc ctgcctcaag cagaaacagg     7500

ttttttattt tcaaccttta tgtatacagt atgttatgtt acatctacag ctaagtttct     7560

ttttagaaga atgtgagccc ttctagcttt ggtttagagt gattctagaa gccaatttcc     7620

ttggcttagt gattctatgc acctttccta aacttagctt tctaaggaaa tgaagtgtac     7680

gagtgagaat gaattcacaa tttcgacatg taggtagcat cctaaagtga aaagaggagg     7740

aaatttgtgg tcaaagcact ctccccacca cttagaaact tactgactgt gggcagcttc     7800

ctcctccaag tttccttcct gatttacaag accgtggtgt ggtcaggatt aaacttgaat     7860

acatgtaagg aagcctgaaa gtgtctaaca catagcgagt attcaaatgc caccttctat     7920

ttgatccttc ccctccagtt ccttaagttt tggaatctag gtttctcagt tccaaatgga     7980

ttgacatttg catatcccca ttgcacaatg gatcaaataa actttatgtt atcatttctc     8040

caacatagtg ccagtaagca aatccttttt aataacaaca gtatgttgag aaacatatca     8100

ccaaataata tttaactttg tagctttgat aagttcttta ggttttggtt ttggttttgt     8160

tttctgagac agggtcttga tctgtcaccc agactggagt gcaatggttc aattttagct     8220

cactgcaacc tgtaactcct gagctcaagt gatcctccca cctcagcctc tcaagtagct     8280

gggactacag gtgtgctcca ccatgcccag cgattttttt tttttttttt tttttttttt     8340

ttggtaggga caaggtctcg ctatgttgcc caggctggtc ttcaattcct ggccttaagt     8400

gatcctcctg cctcggcctc ccaaagtgct ggaattacag gcatgagcca ccacccataa     8460

ctttatgttt gtttttttga tgcagtataa gttcagcttg cttcttatgc agccatacca     8520

tttcatgtta actctgattt ttagcagctt attacattag tgttttatta ttaatataat     8580

tttacagaaa tttactaaac catgactctg tagagtttta ataatactac ctccaaacat     8640

cattgcaaac atctagaaga atgaacaaaa atgatcttag atcgacagta tatctgtttg     8700

tcttagtttc tacacaggat gttcagacat attccatttc tttaaaaaaa aaatatatat     8760

atatatatat atatataggc ctggcacggt ggctcatgac tgtaatccca gcactttggg     8820

aggcttaggc aggcaaatca cctgaggtca ggagtttgag actggcctga ccaacatggt     8880

gaaacctcgt ctctattaaa attacaaaaa ttagccgggc gtggtggcac atgcctgtaa     8940

tcccagctac tcgggaggct gaggcaggag aatcacttga acctgggagg cagaggttgc     9000

agtgagttga gatcacgcca ttgcactcca gccttggtga caagagtgaa actccgtctc     9060

aaaaaaaaaa aaaatatgta tatatatata tatatatata tatatatata tatatatata     9120

tatataaaat cccaccaaaa gtctgcagag tgaccaaatt agacggctct ggtttcagat     9180

taaattctaa atgtgagaaa ccacatagct cccatgatcc atccaataat tcctcacgtc     9240

ctcttcactc tttactccat gcataaaaca gaattttttt ttctcatcct gggtatgaag     9300

caattaataa tttacggatt tagcctattt ggattcaatc ccttcaaact ccatactaca     9360

tccaaggtgg aagtgactta aactctgata tcaatcatca ggcttgtaat ataggctttg     9420

ttaatggcag gagagtctaa taaaactttc tgttccttat ccttcattta aatgaaaaac     9480

tttttattga aaacaatcat aactctagct catcataaat ataattcatg aggacatttt     9540

attattttta tattaaagaa ataatattat agatgtaaac tttgcacctt tctaattatt     9600

atcatgagtt aagctaatac ttgtcttctg gtccctagat gatgattctt ttttgcctta     9660

ctggaggagc ccttgtcttg aagtgagttg cttcaacagc agaggacttc tagtttctcc     9720

cagttgagcc taaagtgaac ttttcatctt cttcagagga aggggcttcc ttgatttgta     9780

cttttgtggc tcctcagata acacagacaa ttttatcttg gatcccaggt tctcttcacc     9840

attaagaata agaaagagag aaaatgctgt gcatgacagc cacctactcc aaactaccca     9900

accccctgta accaggtacc ttccaacaac gagatgattc tgccctcact caagagtctc     9960

ccccacaaag attccattct ccctttactt tttatttttt atttttttgc aaaacaaagg    10020

cctcctttag tacctcctta gtttataacc cttatcttcc cagctcttcc cttcactgat    10080

acctctgatt tcaaaagttc tgaagtcgga agaccacaca atttcagact gtgaacagaa    10140

attcagtcag aaattattgg agttagaaag aatttagaga aattgtattg aactagaaag    10200

tcctctttga ttagtggtgg ccctttagaa agttctaggg cagagtccca tggtgtttca    10260

tcttttccat gatttgcttg accaaaaact tttctttcac aacatgaaaa tatgctaatc    10320

caccacacat tttggattct gctctgtttg cctgaggtgt tagatctcta gccaggactg    10380

tgaagggaag gaacttgaat ccttcctatt gagctattaa tgcagagtca gtgagatgaa    10440

gggttccact cggggtcaaa atcatgtcag ttaccaagca aaggagcaag taaggggaaa    10500

catctcctca tctggttagt ggagccacat ttcacccact gatcaagcca gacctgagca    10560

atagtctaga tttctccctc cacatctaat tggtgacaat ggtgattgta ccactgacag    10620

gtcacacaag tccacaccct ccttcacagc ctcactgctt cggctcttgt ttatgctctt    10680

atcagcatct gtcactagga tccatttgtc tcctgactca tctacttcct ttcactcccc    10740

tgggccatcc ttcacatcat gctagaagac tgtgtctaac ttgcagaact tattgtgtca    10800

atctcctggt tacggcccct ccatggctcc ccacctgaca taggaggccc ttcacaatct    10860

ggcttctgtc actcataact tgtctccagc cttcattctt cagtctgatt ttatggtttt    10920

ctagttcccc aatacaccac accagtgttt atgaaaccct agtcattggc ctacgaactt    10980

tatgattatt gacatattca tgtaccacct gtattatttt ttgcatagtg tttattttta    11040

attgactaca tttttaacta caataaagta atttcaacta aaa                      11083


<210>  158
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  158

Ser Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala 
1               5                   10                  15      


Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met Val 
            20                  25                  30          


Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu 
        35                  40                  45              


Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val Met Ala Ser Phe Tyr Lys 
    50                  55                  60                  


His Leu Gly Ile Glu Phe Met Glu Ala Glu Glu Leu Tyr Gln Lys Arg 
65                  70                  75                  80  


Val Leu Thr Ile Thr Gly Ile Cys Ile Ala Leu Leu Val Val Gly Ile 
                85                  90                  95      


Met Cys Val Val Ala Tyr Cys Lys Thr Lys Lys Gln Arg Lys Lys Leu 
            100                 105                 110         


His Asp Arg Leu Arg Gln Ser Leu Arg Ser Glu Arg Asn Asn Met Met 
        115                 120                 125             


Asn Ile Ala Asn Gly Pro His His Pro Asn Pro Pro Pro Glu Asn Val 
    130                 135                 140                 


Gln Leu Val Asn Gln Tyr Val Ser Lys Asn Val Ile Ser Ser Glu His 
145                 150                 155                 160 


Ile Val Glu Arg Glu Ala Glu Thr Ser Phe Ser Thr Ser His Tyr Thr 
                165                 170                 175     


Ser Thr Ala His His Ser Thr Thr Val Thr Gln Thr Pro Ser His Ser 
            180                 185                 190         


Trp Ser Asn Gly His Thr Glu Ser Ile Leu Ser Glu Ser His Ser Val 
        195                 200                 205             


Ile Val Met Ser Ser Val Glu Asn Ser Arg His Ser Ser Pro Thr Gly 
    210                 215                 220                 


Gly Pro Arg Gly Arg Leu Asn Gly Thr Gly Gly Pro Arg Glu Cys Asn 
225                 230                 235                 240 


Ser Phe Leu Arg His Ala Arg Glu Thr Pro Asp Ser Tyr Arg Asp Ser 
                245                 250                 255     


Pro His Ser Glu Arg Tyr Val Ser Ala Met Thr Thr Pro Ala Arg Met 
            260                 265                 270         


Ser Pro Val Asp Phe His Thr Pro Ser Ser Pro Lys Ser Pro Pro Ser 
        275                 280                 285             


Glu Met Ser Pro Pro Val Ser Ser Met Thr Val Ser Met Pro Ser Met 
    290                 295                 300                 


Ala Val Ser Pro Phe Met Glu Glu Glu Arg Pro Leu Leu Leu Val Thr 
305                 310                 315                 320 


Pro Pro Arg Leu Arg Glu Lys Lys Phe Asp His His Pro Gln Gln Phe 
                325                 330                 335     


Ser Ser Phe His His Asn Pro Ala His Asp Ser Asn Ser Leu Pro Ala 
            340                 345                 350         


Ser Pro Leu Arg Ile Val Glu Asp Glu Glu Tyr Glu Thr Thr Gln Glu 
        355                 360                 365             


Tyr Glu Pro Ala Gln Glu Pro Val Lys Lys Leu Ala Asn Ser Arg Arg 
    370                 375                 380                 


Ala Lys Arg Thr Lys Pro Asn Gly His Ile Ala Asn Arg Leu Glu Val 
385                 390                 395                 400 


Asp Ser Asn Thr Ser Ser Gln Ser Ser Asn Ser Glu Ser Glu Thr Glu 
                405                 410                 415     


Asp Glu Arg Val Gly Glu Asp Thr Pro Phe Leu Gly Ile Gln Asn Pro 
            420                 425                 430         


Leu Ala Ala Ser Leu Glu Ala Thr Pro Ala Phe Arg Leu Ala Asp Ser 
        435                 440                 445             


Arg Thr Asn Pro Ala Gly Arg Phe Ser Thr Gln Glu Glu Ile Gln Ala 
    450                 455                 460                 


Arg Leu Ser Ser Val Ile Ala Asn Gln Asp Pro Ile Ala Val 
465                 470                 475             


<210>  159
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  159
000

<210>  160
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  160
000

<210>  161
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  161
agtaagcctc cgcagcccac tcggactgca gcctgtttgc cgcccgtcct cccattgcag       60

cactcggggc gacagagagg gaggaggcgc gcggggacgg ggacgcccag gaggacccac      120

tcgcgggtcc cgctccgctc cggcagcagc atggggaaag gacgcgcggg ccgagttggc      180

accacagcct tgcctccccg attgaaagag atgaaaagcc aggaatcggc tgcaggttcc      240

aaactagtcc ttcggtgtga aaccagttct gaatactcct ctctcagatt caagtggttc      300

aagaatggga atgaattgaa tcgaaaaaac aaaccacaaa atatcaagat acaaaaaaag      360

ccagggaagt cagaacttcg cattaacaaa gcatcactgg ctgattctgg agagtatatg      420

tgcaaagtga tcagcaaatt aggaaatgac agtgcctctg ccaatatcac catcgtggaa      480

tcaaacgaga tcatcactgg tatgccagcc tcaactgaag gagcatatgt gtcttcagag      540

tctcccatta gaatatcagt atccacagaa ggagcaaata cttctt                     586


<210>  162
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Gly Lys Gly Arg Ala Gly Arg Val Gly Thr Thr Ala Leu Pro Pro 
1               5                   10                  15      


Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu 
            20                  25                  30          


Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg Phe Lys 
        35                  40                  45              


Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys Asn Lys Pro Gln Asn 
    50                  55                  60                  


Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu Leu Arg Ile Asn Lys 
65                  70                  75                  80  


Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys Lys Val Ile Ser Lys 
                85                  90                  95      


Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr Ile Val Glu Ser Asn 
            100                 105                 110         


Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu Gly Ala Tyr Val Ser 
        115                 120                 125             


Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr Glu Gly Ala Asn Thr 
    130                 135                 140                 


Ser 
145 


<210>  163
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  163

His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly 
1               5                   10                  15      


Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
            20                  25                  30          


Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr Val 
        35                  40                  45              


Met Ala Ser Phe 
    50          


<210>  164
<211>  65
<212>  DNA
<213>  Homo sapiens

<400>  164
cataattagc atcatcatta ttctggctgg agcaattgca ctcatcattg gctttggtat       60

ttcag                                                                   65


<210>  165
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  165
ccttgcctcc ccgattgaaa gagatgaa                                          28


<210>  166
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  166
cataattagc atcatcatta ttctggctgg agcaattgca ctcatcattg gctttggtat       60

ttcagccttg cctccccgat tgaaagagat gaa                                    93


<210>  167
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  167

Ile Ile Ser Ile Ile Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile 
1               5                   10                  15      


Gly Phe Gly Ile Ser Ala Leu Pro Pro Arg Leu Lys Glu Met 
            20                  25                  30  


<210>  168
<211>  104
<212>  DNA
<213>  Homo sapiens

<400>  168
gtgagtcacc aaggaaggca gcggcagctc cactcagcca gtacccagat acgctgggaa       60

ccttccccag ccatggcttc cctggggcag atcctcttct ggag                       104


<210>  169
<211>  65
<212>  DNA
<213>  Homo sapiens

<400>  169
cataattagc atcatcatta ttctggctgg agcaattgca ctcatcattg gctttggtat       60

ttcag                                                                   65


<210>  170
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  170
ggagacactc catcacagtc actactgtcg cctcagctgg gaacattggg gaggatggaa       60

tcctgagctg cacttttgaa cctgacatca aactttctga tatcgtgata caatggctga      120

aggaaggtgt tttaggcttg gtccatgagt tcaaagaagg caaagatgag ctgtcggagc      180

aggatgaaat gttcagaggc cggacagcag tgtttgctga tcaagtgata gttggcaatg      240

cctctttgcg gctgaaaaac gtgcaactca cagatgctgg cacctacaaa tgttatatca      300

tcacttctaa aggcaagggg aatgctaacc ttgagtataa aactggag                   348


<210>  171
<211>  279
<212>  DNA
<213>  Homo sapiens

<400>  171
ccttcagcat gccggaagtg aatgtggact ataatgccag ctcagagacc ttgcggtgtg       60

aggctccccg atggttcccc cagcccacag tggtctgggc atcccaagtt gaccagggag      120

ccaacttctc ggaagtctcc aataccagct ttgagctgaa ctctgagaat gtgaccatga      180

aggttgtgtc tgtgctctac aatgttacga tcaacaacac atactcctgt atgattgaaa      240

atgacattgc caaagcaaca ggggatatca aagtgacag                             279


<210>  172
<211>  170
<212>  DNA
<213>  Homo sapiens

<400>  172
aatcggagat caaaaggcgg agtcacctac agctgctaaa ctcaaaggct tctctgtgtg       60

tctcttcttt ctttgccatc agctgggcac ttctgcctct cagcccttac ctgatgctaa      120

aataatgtgc ctcggccaca aaaaagcatg caaagtcatt gttacaacag                 170


<210>  173
<211>  1639
<212>  DNA
<213>  Homo sapiens

<400>  173
ggatctacag aactatttca ccaccagata tgacctagtt ttatatttct gggaggaaat       60

gaattcatat ctagaagtct ggagtgagca aacaagagca agaaacaaaa agaagccaaa      120

agcagaaggc tccaatatga acaagataaa tctatcttca aagacatatt agaagttggg      180

aaaataattc atgtgaacta gacaagtgtg ttaagagtga taagtaaaat gcacgtggag      240

acaagtgcat ccccagatct cagggacctc cccctgcctg tcacctgggg agtgagagga      300

caggatagtg catgttcttt gtctctgaat ttttagttat atgtgctgta atgttgctct      360

gaggaagccc ctggaaagtc tatcccaaca tatccacatc ttatattcca caaattaagc      420

tgtagtatgt accctaagac gctgctaatt gactgccact tcgcaactca ggggcggctg      480

cattttagta atgggtcaaa tgattcactt tttatgatgc ttccaaaggt gccttggctt      540

ctcttcccaa ctgacaaatg ccaaagttga gaaaaatgat cataatttta gcataaacag      600

agcagtcggc gacaccgatt ttataaataa actgagcacc ttctttttaa acaaacaaat      660

gcgggtttat ttctcagatg atgttcatcc gtgaatggtc cagggaagga cctttcacct      720

tgtctatatg gcattatgtc atcacaagct ctgaggcttc tcctttccat cctgcgtgga      780

cagctaagac ctcagttttc aatagcatct agagcagtgg gactcagctg gggtgatttc      840

gccccccatc tccgggggaa tgtctgaaga caattttggt tacctcaatg agggagtgga      900

ggaggataca gtgctactac caactagtgg atagaggcca gggatgctgc tcaacctcct      960

accatgtaca ggacgtctcc ccattacaac tacccaatcc gaagtgtcaa ctgtgtcagg     1020

gctaagaaac cctggttttg agtagaaaag ggcctggaaa gaggggagcc aacaaatctg     1080

tctgcttcct cacattagtc attggcaaat aagcattctg tctctttggc tgctgcctca     1140

gcacagagag ccagaactct atcgggcacc aggataacat ctctcagtga acagagttga     1200

caaggcctat gggaaatgcc tgatgggatt atcttcagct tgttgagctt ctaagtttct     1260

ttcccttcat tctaccctgc aagccaagtt ctgtaagaga aatgcctgag ttctagctca     1320

ggttttctta ctctgaattt agatctccag accctgcctg gccacaattc aaattaaggc     1380

aacaaacata taccttccat gaagcacaca cagacttttg aaagcaagga caatgactgc     1440

ttgaattgag gccttgagga atgaagcttt gaaggaaaag aatactttgt ttccagcccc     1500

cttcccacac tcttcatgtg ttaaccactg ccttcctgga ccttggagcc acggtgactg     1560

tattacatgt tgttatagaa aactgatttt agagttctga tcgttcaaga gaatgattaa     1620

atatacattt cctacacca                                                  1639


<210>  174
<211>  2605
<212>  DNA
<213>  Homo sapiens

<400>  174
gtgagtcacc aaggaaggca gcggcagctc cactcagcca gtacccagat acgctgggaa       60

ccttccccag ccatggcttc cctggggcag atcctcttct ggagcataat tagcatcatc      120

attattctgg ctggagcaat tgcactcatc attggctttg gtatttcagg gagacactcc      180

atcacagtca ctactgtcgc ctcagctggg aacattgggg aggatggaat cctgagctgc      240

acttttgaac ctgacatcaa actttctgat atcgtgatac aatggctgaa ggaaggtgtt      300

ttaggcttgg tccatgagtt caaagaaggc aaagatgagc tgtcggagca ggatgaaatg      360

ttcagaggcc ggacagcagt gtttgctgat caagtgatag ttggcaatgc ctctttgcgg      420

ctgaaaaacg tgcaactcac agatgctggc acctacaaat gttatatcat cacttctaaa      480

ggcaagggga atgctaacct tgagtataaa actggagcct tcagcatgcc ggaagtgaat      540

gtggactata atgccagctc agagaccttg cggtgtgagg ctccccgatg gttcccccag      600

cccacagtgg tctgggcatc ccaagttgac cagggagcca acttctcgga agtctccaat      660

accagctttg agctgaactc tgagaatgtg accatgaagg ttgtgtctgt gctctacaat      720

gttacgatca acaacacata ctcctgtatg attgaaaatg acattgccaa agcaacaggg      780

gatatcaaag tgacagaatc ggagatcaaa aggcggagtc acctacagct gctaaactca      840

aaggcttctc tgtgtgtctc ttctttcttt gccatcagct gggcacttct gcctctcagc      900

ccttacctga tgctaaaata atgtgcctcg gccacaaaaa agcatgcaaa gtcattgtta      960

caacagggat ctacagaact atttcaccac cagatatgac ctagttttat atttctggga     1020

ggaaatgaat tcatatctag aagtctggag tgagcaaaca agagcaagaa acaaaaagaa     1080

gccaaaagca gaaggctcca atatgaacaa gataaatcta tcttcaaaga catattagaa     1140

gttgggaaaa taattcatgt gaactagaca agtgtgttaa gagtgataag taaaatgcac     1200

gtggagacaa gtgcatcccc agatctcagg gacctccccc tgcctgtcac ctggggagtg     1260

agaggacagg atagtgcatg ttctttgtct ctgaattttt agttatatgt gctgtaatgt     1320

tgctctgagg aagcccctgg aaagtctatc ccaacatatc cacatcttat attccacaaa     1380

ttaagctgta gtatgtaccc taagacgctg ctaattgact gccacttcgc aactcagggg     1440

cggctgcatt ttagtaatgg gtcaaatgat tcacttttta tgatgcttcc aaaggtgcct     1500

tggcttctct tcccaactga caaatgccaa agttgagaaa aatgatcata attttagcat     1560

aaacagagca gtcggcgaca ccgattttat aaataaactg agcaccttct ttttaaacaa     1620

acaaatgcgg gtttatttct cagatgatgt tcatccgtga atggtccagg gaaggacctt     1680

tcaccttgtc tatatggcat tatgtcatca caagctctga ggcttctcct ttccatcctg     1740

cgtggacagc taagacctca gttttcaata gcatctagag cagtgggact cagctggggt     1800

gatttcgccc cccatctccg ggggaatgtc tgaagacaat tttggttacc tcaatgaggg     1860

agtggaggag gatacagtgc tactaccaac tagtggatag aggccaggga tgctgctcaa     1920

cctcctacca tgtacaggac gtctccccat tacaactacc caatccgaag tgtcaactgt     1980

gtcagggcta agaaaccctg gttttgagta gaaaagggcc tggaaagagg ggagccaaca     2040

aatctgtctg cttcctcaca ttagtcattg gcaaataagc attctgtctc tttggctgct     2100

gcctcagcac agagagccag aactctatcg ggcaccagga taacatctct cagtgaacag     2160

agttgacaag gcctatggga aatgcctgat gggattatct tcagcttgtt gagcttctaa     2220

gtttctttcc cttcattcta ccctgcaagc caagttctgt aagagaaatg cctgagttct     2280

agctcaggtt ttcttactct gaatttagat ctccagaccc tgcctggcca caattcaaat     2340

taaggcaaca aacatatacc ttccatgaag cacacacaga cttttgaaag caaggacaat     2400

gactgcttga attgaggcct tgaggaatga agctttgaag gaaaagaata ctttgtttcc     2460

agcccccttc ccacactctt catgtgttaa ccactgcctt cctggacctt ggagccacgg     2520

tgactgtatt acatgttgtt atagaaaact gattttagag ttctgatcgt tcaagagaat     2580

gattaaatat acatttccta cacca                                           2605


<210>  175
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp 
1               5                   10  


<210>  176
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  176

Ile Ile Ser Ile Ile Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile 
1               5                   10                  15      


Gly Phe Gly Ile Ser 
            20      


<210>  177
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  177

Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly 
1               5                   10                  15      


Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser 
            20                  25                  30          


Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His 
        35                  40                  45              


Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe 
    50                  55                  60                  


Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala 
65                  70                  75                  80  


Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys 
                85                  90                  95      


Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr 
            100                 105                 110         


Lys Thr Gly 
        115 


<210>  178
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  178

Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr 
1               5                   10                  15      


Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp 
            20                  25                  30          


Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr 
        35                  40                  45              


Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val 
    50                  55                  60                  


Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn 
65                  70                  75                  80  


Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr 
                85                  90          


<210>  179
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  179

Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser Lys Ala 
1               5                   10                  15      


Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro 
            20                  25                  30          


Leu Ser Pro Tyr Leu Met Leu Lys 
        35                  40  


<210>  180
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  181
<211>  169
<212>  DNA
<213>  Homo sapiens

<400>  181
gtgagtcacc aaggaaggca gcggcagctc cactcagcca gtacccagat acgctgggaa       60

ccttccccag ccatggcttc cctggggcag atcctcttct ggagcataat tagcatcatc      120

attattctgg ctggagcaat tgcactcatc attggctttg gtatttcag                  169


<210>  182
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


<210>  183
<211>  0
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  183
000

<210>  184
<211>  119
<212>  DNA
<213>  Homo sapiens

<400>  184
ctggctggag attaatccgg acactggtgc catttccact cgggctgagc tggacaggga       60

ggattttgag cacgtgaaga acagcacgta cacagcccta atcatagcta cagacaatg       119


<210>  185
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  185
ccttgcctcc ccgattgaaa gagatgaaaa                                        30


<210>  186
<211>  148
<212>  DNA
<213>  Homo sapiens

<400>  186
ctggctggag attaatccgg acactggtgc catttccact cgggctgagc tggacaggga       60

ggattttgag cacgtgaaga acagcacgta cacagcccta atcatagcta cagacaatgc      120

cttgcctccc cgattgaaag agatgaaa                                         148


<210>  187
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  187

Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu 
1               5                   10                  15      


Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala 
            20                  25                  30          


Leu Ile Ile Ala Thr Asp Asn Ala Leu Pro Pro Arg Leu Lys Glu Met 
        35                  40                  45              


Lys 
    


<210>  188
<211>  172
<212>  DNA
<213>  Homo sapiens

<400>  188
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc ag              172


<210>  189
<211>  115
<212>  DNA
<213>  Homo sapiens

<400>  189
gtctcctctt ggctctgcca ggagccggag ccctgccacc ctggctttga cgccgagagc       60

tacacgttca cggtgccccg gcgccacctg gagagaggcc gcgtcctggg cagag           115


<210>  190
<211>  224
<212>  DNA
<213>  Homo sapiens

<400>  190
tgaattttga agattgcacc ggtcgacaaa ggacagccta tttttccctc gacacccgat       60

tcaaagtggg cacagatggt gtgattacag tcaaaaggcc tctacggttt cataacccac      120

agatccattt cttggtctac gcctgggact ccacctacag aaagttttcc accaaagtca      180

cgctgaatac agtggggcac caccaccgcc ccccgcccca tcag                       224


<210>  191
<211>  144
<212>  DNA
<213>  Homo sapiens

<400>  191
gcctccgttt ctggaatcca agcagaattg ctcacatttc ccaactcctc tcctggcctc       60

agaagacaga agagagactg ggttattcct cccatcagct gcccagaaaa tgaaaaaggc      120

ccatttccta aaaacctggt tcag                                             144


<210>  192
<211>  156
<212>  DNA
<213>  Homo sapiens

<400>  192
atcaaatcca acaaagacaa agaaggcaag gttttctaca gcatcactgg ccaaggagct       60

gacacacccc ctgttggtgt ctttattatt gaaagagaaa caggatggct gaaggtgaca      120

gagcctctgg atagagaacg cattgccaca tacact                                156


<210>  193
<211>  145
<212>  DNA
<213>  Homo sapiens

<400>  193
ctcttctctc acgctgtgtc atccaacggg aatgcagttg aggatccaat ggagattttg       60

atcacggtaa ccgatcagaa tgacaacaag cccgaattca cccaggaggt ctttaagggg      120

tctgtcatgg aaggtgctct tccag                                            145


<210>  194
<211>  176
<212>  DNA
<213>  Homo sapiens

<400>  194
gaacctctgt gatggaggtc acagccacag acgcggacga tgatgtgaac acctacaatg       60

ccgccatcgc ttacaccatc ctcagccaag atcctgagct ccctgacaaa aatatgttca      120

ccattaacag gaacacagga gtcatcagtg tggtcaccac tgggctggac cgagag          176


<210>  195
<211>  129
<212>  DNA
<213>  Homo sapiens

<400>  195
agtttcccta cgtataccct ggtggttcaa gctgctgacc ttcaaggtga ggggttaagc       60

acaacagcaa cagctgtgat cacagtcact gacaccaacg ataatcctcc gatcttcaat      120

cccaccacg                                                              129


<210>  196
<211>  250
<212>  DNA
<213>  Homo sapiens

<400>  196
tacaagggtc aggtgcctga gaacgaggct aacgtcgtaa tcaccacact gaaagtgact       60

gatgctgatg cccccaatac cccagcgtgg gaggctgtat acaccatatt gaatgatgat      120

ggtggacaat ttgtcgtcac cacaaatcca gtgaacaacg atggcatttt gaaaacagca      180

aaggtttgta tggtacctgg caagatgcag aaactggcat cctcacagct gttcataccc      240

ttgtcccctg                                                             250


<210>  197
<211>  245
<212>  DNA
<213>  Homo sapiens

<400>  197
ggcttggatt ttgaggccaa gcagcagtac attctacacg tagcagtgac gaatgtggta       60

ccttttgagg tctctctcac cacctccaca gccaccgtca ccgtggatgt gctggatgtg      120

aatgaagccc ccatctttgt gcctcctgaa aagagagtgg aagtgtccga ggactttggc      180

gtgggccagg aaatcacatc ctacactgcc caggagccag acacatttat ggaacagaaa      240

ataac                                                                  245


<210>  198
<211>  146
<212>  DNA
<213>  Homo sapiens

<400>  198
atatcggatt tggagagaca ctgccaactg gctggagatt aatccggaca ctggtgccat       60

ttccactcgg gctgagctgg acagggagga ttttgagcac gtgaagaaca gcacgtacac      120

agccctaatc atagctacag acaatg                                           146


<210>  199
<211>  225
<212>  DNA
<213>  Homo sapiens

<400>  199
gttctccagt tgctactgga acagggacac ttctgctgat cctgtctgat gtgaatgaca       60

acgcccccat accagaacct cgaactatat tcttctgtga gaggaatcca aagcctcagg      120

tcataaacat cattgatgca gaccttcctc ccaatacatc tcccttcaca gcagaactaa      180

cacacggggc gagtgccaac tggaccattc agtacaacga cccaa                      225


<210>  200
<211>  228
<212>  DNA
<213>  Homo sapiens

<400>  200
cccaagaatc tatcattttg aagccaaaga tggccttaga ggtgggtgac tacaaaatca       60

atctcaagct catggataac cagaataaag accaagtgac caccttagag gtcagcgtgt      120

gtgactgtga aggggccgct ggcgtctgta ggaaggcaca gcctgtcgaa gcaggattgc      180

aaattcctgc cattctgggg attcttggag gaattcttgc tttgctaa                   228


<210>  201
<211>  131
<212>  DNA
<213>  Homo sapiens

<400>  201
ttctgattct gctgctcttg ctgtttcttc ggaggagagc ggtggtcaaa gagcccttac       60

tgcccccaga ggatgacacc cgggacaacg tttattacta tgatgaagaa ggaggcggag      120

aagaggacca g                                                           131


<210>  202
<211>  144
<212>  DNA
<213>  Homo sapiens

<400>  202
gactttgact tgagccagct gcacaggggc ctggacgctc ggcctgaagt gactcgtaac       60

gacgttgcac caaccctcat gagtgtcccc cggtatcttc cccgccctgc caatcccgat      120

gaaattggaa attttattga tgaa                                             144


<210>  203
<211>  2248
<212>  DNA
<213>  Homo sapiens

<400>  203
aatctgaaag cggctgatac tgaccccaca gccccgcctt atgattctct gctcgtgttt       60

gactatgaag gaagcggttc cgaagctgct agtctgagct ccctgaactc ctcagagtca      120

gacaaagacc aggactatga ctacttgaac gaatggggca atcgcttcaa gaagctggct      180

gacatgtacg gaggcggcga ggacgactag gggactcgag agaggcgggc cccagaccca      240

tgtgctggga aatgcagaaa tcacgttgct ggtggttttt cagctccctt cccttgagat      300

gagtttctgg ggaaaaaaaa gagactggtt agtgatgcag ttagtatagc tttatactct      360

ctccacttta tagctctaat aagtttgtgt tagaaaagtt tcgacttatt tcttaaagct      420

tttttttttt tcccatcact ctttacatgg tggtgatgtc caaaagatac ccaaatttta      480

atattccaga agaacaactt tagcatcaga aggttcaccc agcaccttgc agattttctt      540

aaggaatttt gtctcacttt taaaaagaag gggagaagtc agctactcta gttctgttgt      600

tttgtgtata taatttttta aaaaaaattt gtgtgcttct gctcattact acactggtgt      660

gtccctctgc cttttttttt tttttaagac agggtctcat tctatcggcc aggctggagt      720

gcagtggtgc aatcacagct cactgcagcc ttgtcctccc aggctcaagc tatccttgca      780

cctcagcctc ccaagtagct gggaccacag gcatgcacca ctacgcatga ctaatttttt      840

aaatatttga gacggggtct ccctgtgtta cccaggctgg tctcaaactc ctgggctcaa      900

gtgatcctcc catcttggcc tcccagagta ttgggattac agacatgagc cactgcacct      960

gcccagctcc ccaactccct gccatttttt aagagacagt ttcgctccat cgcccaggcc     1020

tgggatgcag tgatgtgatc atagctcact gtaacctcaa actctggggc tcaagcagtt     1080

ctcccaccag cctccttttt atttttttgt acagatgggg tcttgctatg ttgcccaagc     1140

tggtcttaaa ctcctggcct caagcaatcc ttctgccttg gccccccaaa gtgctgggat     1200

tgtgggcatg agctgctgtg cccagcctcc atgttttaat atcaactctc actcctgaat     1260

tcagttgctt tgcccaagat aggagttctc tgatgcagaa attattgggc tcttttaggg     1320

taagaagttt gtgtctttgt ctggccacat cttgactagg tattgtctac tctgaagacc     1380

tttaatggct tccctctttc atctcctgag tatgtaactt gcaatgggca gctatccagt     1440

gacttgttct gagtaagtgt gttcattaat gtttatttag ctctgaagca agagtgatat     1500

actccaggac ttagaatagt gcctaaagtg ctgcagccaa agacagagcg gaactatgaa     1560

aagtgggctt ggagatggca ggagagcttg tcattgagcc tggcaattta gcaaactgat     1620

gctgaggatg attgaggtgg gtctacctca tctctgaaaa ttctggaagg aatggaggag     1680

tctcaacatg tgtttctgac acaagatccg tggtttgtac tcaaagccca gaatccccaa     1740

gtgcctgctt ttgatgatgt ctacagaaaa tgctggctga gctgaacaca tttgcccaat     1800

tccaggtgtg cacagaaaac cgagaatatt caaaattcca aatttttttc ttaggagcaa     1860

gaagaaaatg tggccctaaa gggggttagt tgaggggtag ggggtagtga ggatcttgat     1920

ttggatctct ttttatttaa atgtgaattt caacttttga caatcaaaga aaagactttt     1980

gttgaaatag ctttactgtt tctcaagtgt tttggagaaa aaaatcaacc ctgcaatcac     2040

tttttggaat tgtcttgatt tttcggcagt tcaagctata tcgaatatag ttctgtgtag     2100

agaatgtcac tgtagttttg agtgtataca tgtgtgggtg ctgataattg tgtattttct     2160

ttgggggtgg aaaaggaaaa caattcaagc tgagaaaagt attctcaaag atgcattttt     2220

ataaatttta ttaaacaatt ttgttaaa                                        2248


<210>  204
<211>  4878
<212>  DNA
<213>  Homo sapiens

<400>  204
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac     1320

tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga     1380

tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc     1440

aaaggtttgt atggtacctg gcaagatgca gaaactggca tcctcacagc tgttcatacc     1500

cttgtcccct gggcttggat tttgaggcca agcagcagta cattctacac gtagcagtga     1560

cgaatgtggt accttttgag gtctctctca ccacctccac agccaccgtc accgtggatg     1620

tgctggatgt gaatgaagcc cccatctttg tgcctcctga aaagagagtg gaagtgtccg     1680

aggactttgg cgtgggccag gaaatcacat cctacactgc ccaggagcca gacacattta     1740

tggaacagaa aataacatat cggatttgga gagacactgc caactggctg gagattaatc     1800

cggacactgg tgccatttcc actcgggctg agctggacag ggaggatttt gagcacgtga     1860

agaacagcac gtacacagcc ctaatcatag ctacagacaa tggttctcca gttgctactg     1920

gaacagggac acttctgctg atcctgtctg atgtgaatga caacgccccc ataccagaac     1980

ctcgaactat attcttctgt gagaggaatc caaagcctca ggtcataaac atcattgatg     2040

cagaccttcc tcccaataca tctcccttca cagcagaact aacacacggg gcgagtgcca     2100

actggaccat tcagtacaac gacccaaccc aagaatctat cattttgaag ccaaagatgg     2160

ccttagaggt gggtgactac aaaatcaatc tcaagctcat ggataaccag aataaagacc     2220

aagtgaccac cttagaggtc agcgtgtgtg actgtgaagg ggccgctggc gtctgtagga     2280

aggcacagcc tgtcgaagca ggattgcaaa ttcctgccat tctggggatt cttggaggaa     2340

ttcttgcttt gctaattctg attctgctgc tcttgctgtt tcttcggagg agagcggtgg     2400

tcaaagagcc cttactgccc ccagaggatg acacccggga caacgtttat tactatgatg     2460

aagaaggagg cggagaagag gaccaggact ttgacttgag ccagctgcac aggggcctgg     2520

acgctcggcc tgaagtgact cgtaacgacg ttgcaccaac cctcatgagt gtcccccggt     2580

atcttccccg ccctgccaat cccgatgaaa ttggaaattt tattgatgaa aatctgaaag     2640

cggctgatac tgaccccaca gccccgcctt atgattctct gctcgtgttt gactatgaag     2700

gaagcggttc cgaagctgct agtctgagct ccctgaactc ctcagagtca gacaaagacc     2760

aggactatga ctacttgaac gaatggggca atcgcttcaa gaagctggct gacatgtacg     2820

gaggcggcga ggacgactag gggactcgag agaggcgggc cccagaccca tgtgctggga     2880

aatgcagaaa tcacgttgct ggtggttttt cagctccctt cccttgagat gagtttctgg     2940

ggaaaaaaaa gagactggtt agtgatgcag ttagtatagc tttatactct ctccacttta     3000

tagctctaat aagtttgtgt tagaaaagtt tcgacttatt tcttaaagct tttttttttt     3060

tcccatcact ctttacatgg tggtgatgtc caaaagatac ccaaatttta atattccaga     3120

agaacaactt tagcatcaga aggttcaccc agcaccttgc agattttctt aaggaatttt     3180

gtctcacttt taaaaagaag gggagaagtc agctactcta gttctgttgt tttgtgtata     3240

taatttttta aaaaaaattt gtgtgcttct gctcattact acactggtgt gtccctctgc     3300

cttttttttt tttttaagac agggtctcat tctatcggcc aggctggagt gcagtggtgc     3360

aatcacagct cactgcagcc ttgtcctccc aggctcaagc tatccttgca cctcagcctc     3420

ccaagtagct gggaccacag gcatgcacca ctacgcatga ctaatttttt aaatatttga     3480

gacggggtct ccctgtgtta cccaggctgg tctcaaactc ctgggctcaa gtgatcctcc     3540

catcttggcc tcccagagta ttgggattac agacatgagc cactgcacct gcccagctcc     3600

ccaactccct gccatttttt aagagacagt ttcgctccat cgcccaggcc tgggatgcag     3660

tgatgtgatc atagctcact gtaacctcaa actctggggc tcaagcagtt ctcccaccag     3720

cctccttttt atttttttgt acagatgggg tcttgctatg ttgcccaagc tggtcttaaa     3780

ctcctggcct caagcaatcc ttctgccttg gccccccaaa gtgctgggat tgtgggcatg     3840

agctgctgtg cccagcctcc atgttttaat atcaactctc actcctgaat tcagttgctt     3900

tgcccaagat aggagttctc tgatgcagaa attattgggc tcttttaggg taagaagttt     3960

gtgtctttgt ctggccacat cttgactagg tattgtctac tctgaagacc tttaatggct     4020

tccctctttc atctcctgag tatgtaactt gcaatgggca gctatccagt gacttgttct     4080

gagtaagtgt gttcattaat gtttatttag ctctgaagca agagtgatat actccaggac     4140

ttagaatagt gcctaaagtg ctgcagccaa agacagagcg gaactatgaa aagtgggctt     4200

ggagatggca ggagagcttg tcattgagcc tggcaattta gcaaactgat gctgaggatg     4260

attgaggtgg gtctacctca tctctgaaaa ttctggaagg aatggaggag tctcaacatg     4320

tgtttctgac acaagatccg tggtttgtac tcaaagccca gaatccccaa gtgcctgctt     4380

ttgatgatgt ctacagaaaa tgctggctga gctgaacaca tttgcccaat tccaggtgtg     4440

cacagaaaac cgagaatatt caaaattcca aatttttttc ttaggagcaa gaagaaaatg     4500

tggccctaaa gggggttagt tgaggggtag ggggtagtga ggatcttgat ttggatctct     4560

ttttatttaa atgtgaattt caacttttga caatcaaaga aaagactttt gttgaaatag     4620

ctttactgtt tctcaagtgt tttggagaaa aaaatcaacc ctgcaatcac tttttggaat     4680

tgtcttgatt tttcggcagt tcaagctata tcgaatatag ttctgtgtag agaatgtcac     4740

tgtagttttg agtgtataca tgtgtgggtg ctgataattg tgtattttct ttgggggtgg     4800

aaaaggaaaa caattcaagc tgagaaaagt attctcaaag atgcattttt ataaatttta     4860

ttaaacaatt ttgttaaa                                                   4878


<210>  205
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Glu Gln Lys Ile 
1               5   


<210>  206
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  206

Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp 
1               5                   10                  15      


Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu 
            20                  25                  30          


His Val Lys Asn Ser Thr Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn 
        35                  40                  45              


<210>  207
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  207

Ser Pro Val Ala Thr Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp 
1               5                   10                  15      


Val Asn Asp Asn Ala Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys 
            20                  25                  30          


Glu Arg Asn Pro Lys Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu 
        35                  40                  45              


Pro Pro Asn Thr Ser Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser 
    50                  55                  60                  


Ala Asn Trp Thr Ile Gln Tyr Asn Asp Pro 
65                  70                  


<210>  208
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  208

Gln Glu Ser Ile Ile Leu Lys Pro Lys Met Ala Leu Glu Val Gly Asp 
1               5                   10                  15      


Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn Gln Asn Lys Asp Gln Val 
            20                  25                  30          


Thr Thr Leu Glu Val Ser Val Cys Asp Cys Glu Gly Ala Ala Gly Val 
        35                  40                  45              


Cys Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro Ala Ile 
    50                  55                  60                  


Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu Leu 
65                  70                  75  


<210>  209
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  209

Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val Val Lys 
1               5                   10                  15      


Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val Tyr Tyr 
            20                  25                  30          


Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln 
        35                  40              


<210>  210
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  210

Asp Phe Asp Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu 
1               5                   10                  15      


Val Thr Arg Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr 
            20                  25                  30          


Leu Pro Arg Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu 
        35                  40                  45              


<210>  211
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  211

Asn Leu Lys Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser 
1               5                   10                  15      


Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu 
            20                  25                  30          


Ser Ser Leu Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr 
        35                  40                  45              


Leu Asn Glu Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly 
    50                  55                  60                  


Gly Gly Glu Asp Asp 
65                  


<210>  212
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp 
1               5                   10                  15      


Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu 
            20                  25                  30          


Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala Leu 
        35                  40                  45              


Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr Gly Thr Gly Thr 
    50                  55                  60                  


Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala Pro Ile Pro Glu 
65                  70                  75                  80  


Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys Pro Gln Val Ile 
                85                  90                  95      


Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser Pro Phe Thr Ala 
            100                 105                 110         


Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile Gln Tyr Asn Asp 
        115                 120                 125             


Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met Ala Leu Glu Val 
    130                 135                 140                 


Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn Gln Asn Lys Asp 
145                 150                 155                 160 


Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys Glu Gly Ala Ala 
                165                 170                 175     


Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro 
            180                 185                 190         


Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu Leu Ile Leu Ile 
        195                 200                 205             


Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val Val Lys Glu Pro 
    210                 215                 220                 


Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val Tyr Tyr Tyr Asp 
225                 230                 235                 240 


Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp Leu Ser Gln Leu 
                245                 250                 255     


His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg Asn Asp Val Ala 
            260                 265                 270         


Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg Pro Ala Asn Pro 
        275                 280                 285             


Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys Ala Ala Asp Thr 
    290                 295                 300                 


Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu 
305                 310                 315                 320 


Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu Asn Ser Ser Glu 
                325                 330                 335     


Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Asn Arg 
            340                 345                 350         


Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
        355                 360                 365     


<210>  213
<211>  1902
<212>  DNA
<213>  Homo sapiens

<400>  213
agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc       60

gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc      120

agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc      180

ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt      240

cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga      300

ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac      360

agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt      420

ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt      480

ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt      540

gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc      600

tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa      660

atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac      720

accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc      780

tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg      840

gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa      900

gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac      960

ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc     1020

catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat     1080

taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc     1140

tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc     1200

aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac     1260

gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac     1320

tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga     1380

tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc     1440

aaaggtttgt atggtacctg gcaagatgca gaaactggca tcctcacagc tgttcatacc     1500

cttgtcccct gggcttggat tttgaggcca agcagcagta cattctacac gtagcagtga     1560

cgaatgtggt accttttgag gtctctctca ccacctccac agccaccgtc accgtggatg     1620

tgctggatgt gaatgaagcc cccatctttg tgcctcctga aaagagagtg gaagtgtccg     1680

aggactttgg cgtgggccag gaaatcacat cctacactgc ccaggagcca gacacattta     1740

tggaacagaa aataacatat cggatttgga gagacactgc caactggctg gagattaatc     1800

cggacactgg tgccatttcc actcgggctg agctggacag ggaggatttt gagcacgtga     1860

agaacagcac gtacacagcc ctaatcatag ctacagacaa tg                        1902


<210>  214
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Glu Gln Lys Ile Tyr Arg Ile Trp Arg Asp Thr Ala Asn Trp Leu 
1               5                   10                  15      


Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr Arg Ala Glu Leu Asp 
            20                  25                  30          


Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr Tyr Thr Ala Leu Ile 
        35                  40                  45              


Ile Ala Thr Asp Asn 
    50              


<210>  215
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  215
atggcgctcc tgctgtgctt cgtgctcctg tgcggagtag tgg                         43


<210>  216
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  216
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaact         58


<210>  217
<211>  101
<212>  DNA
<213>  Homo sapiens

<400>  217
atggcgctcc tgctgtgctt cgtgctcctg tgcggagtag tggccttgcc tccccgattg       60

aaagagatga aaagccagga atcggctgca ggttccaaac t                          101


<210>  218
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Ala Leu 
1               5                   10                  15      


Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser 
            20                  25                  30          


Lys 
    


<210>  219
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  219
agtcgggagc gcgcgaggcg cggggagcct gggaccagga gcgagagccg cctacctgca       60

gccgccgccc acggcacggc agccaccatg gcgctcctgc tgtgcttcgt gctcctgtgc      120

ggagtagtgg                                                             130


<210>  220
<211>  167
<212>  DNA
<213>  Homo sapiens

<400>  220
atttcgccag aagtttgagt atcactactc ctgaagagat gattgaaaaa gccaaagggg       60

aaactgccta tctgccatgc aaatttacgc ttagtcccga agaccaggga ccgctggaca      120

tcgagtggct gatatcacca gctgataatc agaaggtgga tcaagtg                    167


<210>  221
<211>  205
<212>  DNA
<213>  Homo sapiens

<400>  221
attattttat attctggaga caaaatttat gatgactact atccagatct gaaaggccga       60

gtacatttta cgagtaatga tctcaaatct ggtgatgcat caataaatgt aacgaattta      120

caactgtcag atattggcac atatcagtgc aaagtgaaaa aagctcctgg tgttgcaaat      180

aagaagattc atctggtagt tcttg                                            205


<210>  222
<211>  156
<212>  DNA
<213>  Homo sapiens

<400>  222
ttaagccttc aggtgcgaga tgttacgttg atggatctga agaaattgga agtgacttta       60

agataaaatg tgaaccaaaa gaaggttcac ttccattaca gtatgagtgg caaaaattgt      120

ctgactcaca gaaaatgccc acttcatggt tagcag                                156


<210>  223
<211>  4683
<212>  DNA
<213>  Homo sapiens

<400>  223
ggaagatgtg ccacctccaa agagccgtac gtccactgcc agaagctaca tcggcagtaa       60

tcattcatcc ctggggtcca tgtctccttc caacatggaa ggatattcca agactcagta      120

taaccaagta ccaagtgaag actttgaacg cactcctcag agtccgactc tcccacctgc      180

taaggtagct gcccctaatc taagtcgaat gggtgcgatt cctgtgatga ttccagcaca      240

gagcaaggat gggtctatag tatagagcct ccatatgtct catctgtgct ctccgtgttc      300

ctttcctttt tttgatatat gaaaacctat tctggtctaa attgtgttac tagcctcaaa      360

atacatcaaa aaataagtta atcaggaact gtacggaata tatttttaaa aatttttgtt      420

tggttatatc gaaatagtta caggcactaa agttagtaaa gaaaagttta ccatctgaaa      480

aagctggatt ttctttaaga ggttgattat aaagttttct aaatttatca gtacctaagt      540

aagatgtagc gctttgaata tgaaatcata ggtgaagaca tgggtgaact tacttgcata      600

ccaagttgat acttgaataa ccatctgaaa gtggtacttg atcattttta ccattatttt      660

taggatgtgt atttcattta tttatggccc accagtctcc cccaaattag tacagaaata      720

tccatgacaa aattacttac gtatgtttgt acttggtttt acagctcctt tgaaaactct      780

gtgtttggaa tatctctaaa aacatagaaa acactacagt ggtttagaaa ttactaattt      840

tacttctaag tcattcataa accttgtcta tgaaatgact tcttaaatat ttagttgata      900

gactgctaca ggtaataggg acttagcaag ctcttttata tgctaaagga gcatctatca      960

gattaagtta gaacatttgc tgtcagccac atattgagat gacactaggt gcaatagcag     1020

ggatagattt tgttggtgag tagtctcatg ccttgagatc tgtggtggtc ttcaaaatgg     1080

tggccagcca gatcaaggat gtagtatctc atagttccca ggtgatattt ttcttattag     1140

aaaaatatta taactcattt gttgtttgac acttatagat tgaaatttcc taatttattc     1200

taaattttaa gtggttcttt ggttccagtg ctttatgttg ttgttgtttt tggatggtgt     1260

tacatattat atgttctaga aacatgtaat cctaaattta ccctcttgaa tataatccct     1320

ggatgatatt ttttatcata aatgcagaat aatcaaatac attttaagca agttaagtgt     1380

cctccatcaa ttctgtattc cagacttggg aggatgtaca gttgctgttg tgtgatcaaa     1440

catgtctctg tgtagttcca gcaaatcaag ctgagctttg aaaaagtttg tcttagtttt     1500

gtgaaggtga tttattctta aaaaaaaaaa agaaagaaaa agaaaaaaag ataagaagga     1560

ggagtaaagg gactactcct ccttgccaaa tgtgctaaat atcattttag gagaagaaag     1620

tgggtttatt gtatttccct taagattgtg agggagtgtg gatacagtag aatgagccaa     1680

cagtttcttt ataataaata cggtctgcaa taaattattt cactagctct aaaacctttc     1740

cctagatttt agtagggagt tggtttctgt taatatcttt gggtgctgtg gtggtaaatg     1800

ctatattatg aacggtggca tgtatttaca gttagagtat tgtgtgtaca ctttttaatg     1860

gtaaacttaa gctgaatgtg taatggattt gtgtatagtt ttacatattt ggaagcattt     1920

taaaaacagg ttttaacctt atgtaaaatt acttttatac tcgtgttaac attttcatct     1980

gtgccttttg gtaatttaat ttctattatg aatttctggt gcctatgagc tagctatcac     2040

ctacctgaaa ggtgcttaga ggtgaaggta ctgtttctaa aaacacatca ctgtgatacc     2100

tttctatcct cacattttca agcttgcctc ttttctgttc tttgtggata taacttaagc     2160

aattgtgtta ttcataaagg tttagaaatt tcaatattcc caacactcta tgtttctgat     2220

tttataacag tagccatttt tgaaagtcag atgtttggcc tgttttatat gaataaagtt     2280

tatttataaa atattataaa aaataagtaa ataaacagaa cattaataat aaagttttgg     2340

ttcttcctat tcctgacttt catataatga aaattatcct attgatctaa gtagaagtta     2400

tcatagaaag tggacacgta taagactttc cttccttttt ttttttaata acatatgagg     2460

aacaagactt ctcttcccat atacttcata ttttagagga cattgtttta aaggcttatg     2520

tctcactgta aaattctgtc agccaaatag taccaatacg ttttcaagta gttctcactg     2580

ataatttagt tgaaccagag atcaaatatt tgctcccgaa ttactactgg taatcaagta     2640

gttgaacaaa aaattactaa agcatttccg ttagatcagt caaggacagt actgcatctt     2700

tttttttttt ttttttttta agacggagtc tcggtctgtc acccaggctg gagtgcagtg     2760

gcgggatctc ggctcactgc aagctccgcc tcccaggttc acgccattct cctgcctcag     2820

cctcccgagc agctgggact acaggctccc atcaccacgc tcggctaagt ttttgtaatt     2880

ttagtagaga cagggtttca ccgtgttagc caggatggtc tcgatctcct gacctcgtga     2940

tctgcctgcc tcggcctccc aaagtgctgg gattacaggc gtgaaccact gcacccggcc     3000

cagtactgca tcttaacagc aaagccattt tattctactt tataactgag agacttgata     3060

ccatccatct ctttaggtta cagaggataa tttgaagaga aatgttactg tagaatatat     3120

agttctgtac tttttttttt tttttttaag agatagggtt tcactattgc tcaggctggt     3180

ctcaaactgc tgggctcagg agatcctcct gccttggcct cccaaattgc tgggattaca     3240

ggtgtgagcc gcagcatcca gccagttctg tactttgaat atggagtagt ttacagctat     3300

ttttttttct tactggtaat cttaactaat atgattccct tgttagagag cctctcactc     3360

ccccaccccc aaaaatgtct actattcatg acagtaacca attattctgg acaaattgct     3420

tctttttaat ttgagctatc tgccatggac tttctaaaat ggaaacacag cctgagtgta     3480

tcttagggag agtttgattg aaaaaatcca aatcactatc catatagatc atggatataa     3540

agagatacct gatttttatt aaaaagatac tttttcaaat ttaagagtta atcttggaaa     3600

tttggaacaa gtaaaggggc aagtaaacct tttgatgaaa tataaaagga actcattgca     3660

tgaagttgac tatcaaattc tgtgatgtgt ggcttcttaa aaatattctc agtgtctttt     3720

gtgtgcgtgc agcatgtaca tttgatgtta tgtgaatgtt gagttttttc ttctaatttt     3780

cacttcagca gtgtttaggg ctttcagatg ccttattcca gtgtgaacag aaaaagttca     3840

tattttatgt ggttaatgct ttgatgtgtc acataaagag tagtttgtag aaaatgttgg     3900

cacaatttta acttcttagt ggcttgtgac attatatatt atatatatat atgtacatat     3960

atctttataa cattcctgtg tttagtagtg taaatgttct gggcaagttt taatattttg     4020

aatgcctttg gatattccag caataaaggc atcatgttct gcaataggat ttcttactca     4080

tttacctatt ttaacactaa aatagaccac aactgagcac aaattccttt tataaatgtt     4140

atagaagcag ggaagaataa taaacacatt tgtgaattgt ggttcagttt atttatcttt     4200

agggaaggct gatcatttat cttatagcag ataaccccag cctcttattc attatggtta     4260

acttttataa tttatcttat tttataattt aagaatatag tacatatcag ttgggtttgg     4320

ttttggtcat cgagactaaa agctccatca aaacagaact ttgtgttttc tgctaactta     4380

tttaatgaca caagttttaa gagaaccaca attcattgat tcacttattc ttttccctaa     4440

ttgtgaattt tagtgataaa tacacctgta ctactgagga aaatattctg acacttcacg     4500

tgtgcaaagt atagaactga cagtgtcagt ttcagatttt gtatgtacga tttctggctt     4560

atatatccaa tggtgcagat tttgaaattt gtaagaacaa aatttgttaa gaaaaacaac     4620

ttgctctagt tttgtgacct tgtgtacttt tgaaataaaa tcaagaaagc agttctctgc     4680

ctc                                                                   4683


<210>  224
<211>  5341
<212>  DNA
<213>  Homo sapiens

<400>  224
agtcgggagc gcgcgaggcg cggggagcct gggaccagga gcgagagccg cctacctgca       60

gccgccgccc acggcacggc agccaccatg gcgctcctgc tgtgcttcgt gctcctgtgc      120

ggagtagtgg atttcgccag aagtttgagt atcactactc ctgaagagat gattgaaaaa      180

gccaaagggg aaactgccta tctgccatgc aaatttacgc ttagtcccga agaccaggga      240

ccgctggaca tcgagtggct gatatcacca gctgataatc agaaggtgga tcaagtgatt      300

attttatatt ctggagacaa aatttatgat gactactatc cagatctgaa aggccgagta      360

cattttacga gtaatgatct caaatctggt gatgcatcaa taaatgtaac gaatttacaa      420

ctgtcagata ttggcacata tcagtgcaaa gtgaaaaaag ctcctggtgt tgcaaataag      480

aagattcatc tggtagttct tgttaagcct tcaggtgcga gatgttacgt tgatggatct      540

gaagaaattg gaagtgactt taagataaaa tgtgaaccaa aagaaggttc acttccatta      600

cagtatgagt ggcaaaaatt gtctgactca cagaaaatgc ccacttcatg gttagcaggg      660

aagatgtgcc acctccaaag agccgtacgt ccactgccag aagctacatc ggcagtaatc      720

attcatccct ggggtccatg tctccttcca acatggaagg atattccaag actcagtata      780

accaagtacc aagtgaagac tttgaacgca ctcctcagag tccgactctc ccacctgcta      840

aggtagctgc ccctaatcta agtcgaatgg gtgcgattcc tgtgatgatt ccagcacaga      900

gcaaggatgg gtctatagta tagagcctcc atatgtctca tctgtgctct ccgtgttcct      960

ttcctttttt tgatatatga aaacctattc tggtctaaat tgtgttacta gcctcaaaat     1020

acatcaaaaa ataagttaat caggaactgt acggaatata tttttaaaaa tttttgtttg     1080

gttatatcga aatagttaca ggcactaaag ttagtaaaga aaagtttacc atctgaaaaa     1140

gctggatttt ctttaagagg ttgattataa agttttctaa atttatcagt acctaagtaa     1200

gatgtagcgc tttgaatatg aaatcatagg tgaagacatg ggtgaactta cttgcatacc     1260

aagttgatac ttgaataacc atctgaaagt ggtacttgat catttttacc attattttta     1320

ggatgtgtat ttcatttatt tatggcccac cagtctcccc caaattagta cagaaatatc     1380

catgacaaaa ttacttacgt atgtttgtac ttggttttac agctcctttg aaaactctgt     1440

gtttggaata tctctaaaaa catagaaaac actacagtgg tttagaaatt actaatttta     1500

cttctaagtc attcataaac cttgtctatg aaatgacttc ttaaatattt agttgataga     1560

ctgctacagg taatagggac ttagcaagct cttttatatg ctaaaggagc atctatcaga     1620

ttaagttaga acatttgctg tcagccacat attgagatga cactaggtgc aatagcaggg     1680

atagattttg ttggtgagta gtctcatgcc ttgagatctg tggtggtctt caaaatggtg     1740

gccagccaga tcaaggatgt agtatctcat agttcccagg tgatattttt cttattagaa     1800

aaatattata actcatttgt tgtttgacac ttatagattg aaatttccta atttattcta     1860

aattttaagt ggttctttgg ttccagtgct ttatgttgtt gttgtttttg gatggtgtta     1920

catattatat gttctagaaa catgtaatcc taaatttacc ctcttgaata taatccctgg     1980

atgatatttt ttatcataaa tgcagaataa tcaaatacat tttaagcaag ttaagtgtcc     2040

tccatcaatt ctgtattcca gacttgggag gatgtacagt tgctgttgtg tgatcaaaca     2100

tgtctctgtg tagttccagc aaatcaagct gagctttgaa aaagtttgtc ttagttttgt     2160

gaaggtgatt tattcttaaa aaaaaaaaag aaagaaaaag aaaaaaagat aagaaggagg     2220

agtaaaggga ctactcctcc ttgccaaatg tgctaaatat cattttagga gaagaaagtg     2280

ggtttattgt atttccctta agattgtgag ggagtgtgga tacagtagaa tgagccaaca     2340

gtttctttat aataaatacg gtctgcaata aattatttca ctagctctaa aacctttccc     2400

tagattttag tagggagttg gtttctgtta atatctttgg gtgctgtggt ggtaaatgct     2460

atattatgaa cggtggcatg tatttacagt tagagtattg tgtgtacact ttttaatggt     2520

aaacttaagc tgaatgtgta atggatttgt gtatagtttt acatatttgg aagcatttta     2580

aaaacaggtt ttaaccttat gtaaaattac ttttatactc gtgttaacat tttcatctgt     2640

gccttttggt aatttaattt ctattatgaa tttctggtgc ctatgagcta gctatcacct     2700

acctgaaagg tgcttagagg tgaaggtact gtttctaaaa acacatcact gtgatacctt     2760

tctatcctca cattttcaag cttgcctctt ttctgttctt tgtggatata acttaagcaa     2820

ttgtgttatt cataaaggtt tagaaatttc aatattccca acactctatg tttctgattt     2880

tataacagta gccatttttg aaagtcagat gtttggcctg ttttatatga ataaagttta     2940

tttataaaat attataaaaa ataagtaaat aaacagaaca ttaataataa agttttggtt     3000

cttcctattc ctgactttca tataatgaaa attatcctat tgatctaagt agaagttatc     3060

atagaaagtg gacacgtata agactttcct tccttttttt ttttaataac atatgaggaa     3120

caagacttct cttcccatat acttcatatt ttagaggaca ttgttttaaa ggcttatgtc     3180

tcactgtaaa attctgtcag ccaaatagta ccaatacgtt ttcaagtagt tctcactgat     3240

aatttagttg aaccagagat caaatatttg ctcccgaatt actactggta atcaagtagt     3300

tgaacaaaaa attactaaag catttccgtt agatcagtca aggacagtac tgcatctttt     3360

tttttttttt tttttttaag acggagtctc ggtctgtcac ccaggctgga gtgcagtggc     3420

gggatctcgg ctcactgcaa gctccgcctc ccaggttcac gccattctcc tgcctcagcc     3480

tcccgagcag ctgggactac aggctcccat caccacgctc ggctaagttt ttgtaatttt     3540

agtagagaca gggtttcacc gtgttagcca ggatggtctc gatctcctga cctcgtgatc     3600

tgcctgcctc ggcctcccaa agtgctggga ttacaggcgt gaaccactgc acccggccca     3660

gtactgcatc ttaacagcaa agccatttta ttctacttta taactgagag acttgatacc     3720

atccatctct ttaggttaca gaggataatt tgaagagaaa tgttactgta gaatatatag     3780

ttctgtactt tttttttttt tttttaagag atagggtttc actattgctc aggctggtct     3840

caaactgctg ggctcaggag atcctcctgc cttggcctcc caaattgctg ggattacagg     3900

tgtgagccgc agcatccagc cagttctgta ctttgaatat ggagtagttt acagctattt     3960

ttttttctta ctggtaatct taactaatat gattcccttg ttagagagcc tctcactccc     4020

ccacccccaa aaatgtctac tattcatgac agtaaccaat tattctggac aaattgcttc     4080

tttttaattt gagctatctg ccatggactt tctaaaatgg aaacacagcc tgagtgtatc     4140

ttagggagag tttgattgaa aaaatccaaa tcactatcca tatagatcat ggatataaag     4200

agatacctga tttttattaa aaagatactt tttcaaattt aagagttaat cttggaaatt     4260

tggaacaagt aaaggggcaa gtaaaccttt tgatgaaata taaaaggaac tcattgcatg     4320

aagttgacta tcaaattctg tgatgtgtgg cttcttaaaa atattctcag tgtcttttgt     4380

gtgcgtgcag catgtacatt tgatgttatg tgaatgttga gttttttctt ctaattttca     4440

cttcagcagt gtttagggct ttcagatgcc ttattccagt gtgaacagaa aaagttcata     4500

ttttatgtgg ttaatgcttt gatgtgtcac ataaagagta gtttgtagaa aatgttggca     4560

caattttaac ttcttagtgg cttgtgacat tatatattat atatatatat gtacatatat     4620

ctttataaca ttcctgtgtt tagtagtgta aatgttctgg gcaagtttta atattttgaa     4680

tgcctttgga tattccagca ataaaggcat catgttctgc aataggattt cttactcatt     4740

tacctatttt aacactaaaa tagaccacaa ctgagcacaa attcctttta taaatgttat     4800

agaagcaggg aagaataata aacacatttg tgaattgtgg ttcagtttat ttatctttag     4860

ggaaggctga tcatttatct tatagcagat aaccccagcc tcttattcat tatggttaac     4920

ttttataatt tatcttattt tataatttaa gaatatagta catatcagtt gggtttggtt     4980

ttggtcatcg agactaaaag ctccatcaaa acagaacttt gtgttttctg ctaacttatt     5040

taatgacaca agttttaaga gaaccacaat tcattgattc acttattctt ttccctaatt     5100

gtgaatttta gtgataaata cacctgtact actgaggaaa atattctgac acttcacgtg     5160

tgcaaagtat agaactgaca gtgtcagttt cagattttgt atgtacgatt tctggcttat     5220

atatccaatg gtgcagattt tgaaatttgt aagaacaaaa tttgttaaga aaaacaactt     5280

gctctagttt tgtgaccttg tgtacttttg aaataaaatc aagaaagcag ttctctgcct     5340

c                                                                     5341


<210>  225
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val 
1               5                   10                  


<210>  226
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  226

Phe Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys 
1               5                   10                  15      


Ala Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro 
            20                  25                  30          


Glu Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp 
        35                  40                  45              


Asn Gln Lys Val Asp Gln Val 
    50                  55  


<210>  227
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  227

Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr Asp Asp Tyr Tyr Pro Asp 
1               5                   10                  15      


Leu Lys Gly Arg Val His Phe Thr Ser Asn Asp Leu Lys Ser Gly Asp 
            20                  25                  30          


Ala Ser Ile Asn Val Thr Asn Leu Gln Leu Ser Asp Ile Gly Thr Tyr 
        35                  40                  45              


Gln Cys Lys Val Lys Lys Ala Pro Gly Val Ala Asn Lys Lys Ile His 
    50                  55                  60                  


Leu Val Val Leu 
65              


<210>  228
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  228

Lys Pro Ser Gly Ala Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly 
1               5                   10                  15      


Ser Asp Phe Lys Ile Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu 
            20                  25                  30          


Gln Tyr Glu Trp Gln Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser 
        35                  40                  45              


Trp Leu Ala 
    50      


<210>  229
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  229

Lys Met Cys His Leu Gln Arg Ala Val Arg Pro Leu Pro Glu Ala Thr 
1               5                   10                  15      


Ser Ala Val Ile Ile His Pro Trp Gly Pro Cys Leu Leu Pro Thr Trp 
            20                  25                  30          


Lys Asp Ile Pro Arg Leu Ser Ile Thr Lys Tyr Gln Val Lys Thr Leu 
        35                  40                  45              


Asn Ala Leu Leu Arg Val Arg Leu Ser His Leu Leu Arg 
    50                  55                  60      


<210>  230
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Ala Leu Leu Leu Cys Phe Val Leu Leu Cys Gly Val Val Asp Phe 
1               5                   10                  15      


Ala Arg Ser Leu Ser Ile Thr Thr Pro Glu Glu Met Ile Glu Lys Ala 
            20                  25                  30          


Lys Gly Glu Thr Ala Tyr Leu Pro Cys Lys Phe Thr Leu Ser Pro Glu 
        35                  40                  45              


Asp Gln Gly Pro Leu Asp Ile Glu Trp Leu Ile Ser Pro Ala Asp Asn 
    50                  55                  60                  


Gln Lys Val Asp Gln Val Ile Ile Leu Tyr Ser Gly Asp Lys Ile Tyr 
65                  70                  75                  80  


Asp Asp Tyr Tyr Pro Asp Leu Lys Gly Arg Val His Phe Thr Ser Asn 
                85                  90                  95      


Asp Leu Lys Ser Gly Asp Ala Ser Ile Asn Val Thr Asn Leu Gln Leu 
            100                 105                 110         


Ser Asp Ile Gly Thr Tyr Gln Cys Lys Val Lys Lys Ala Pro Gly Val 
        115                 120                 125             


Ala Asn Lys Lys Ile His Leu Val Val Leu Val Lys Pro Ser Gly Ala 
    130                 135                 140                 


Arg Cys Tyr Val Asp Gly Ser Glu Glu Ile Gly Ser Asp Phe Lys Ile 
145                 150                 155                 160 


Lys Cys Glu Pro Lys Glu Gly Ser Leu Pro Leu Gln Tyr Glu Trp Gln 
                165                 170                 175     


Lys Leu Ser Asp Ser Gln Lys Met Pro Thr Ser Trp Leu Ala Gly Lys 
            180                 185                 190         


Met Cys His Leu Gln Arg Ala Val Arg Pro Leu Pro Glu Ala Thr Ser 
        195                 200                 205             


Ala Val Ile Ile His Pro Trp Gly Pro Cys Leu Leu Pro Thr Trp Lys 
    210                 215                 220                 


Asp Ile Pro Arg Leu Ser Ile Thr Lys Tyr Gln Val Lys Thr Leu Asn 
225                 230                 235                 240 


Ala Leu Leu Arg Val Arg Leu Ser His Leu Leu Arg 
                245                 250         


<210>  231
<211>  141
<212>  DNA
<213>  Homo sapiens

<400>  231
gggagctgtt caaaaaacga gctctttcta ctcctgtagt agaaaaacgt tcagcatctt       60

ctgagtcatc atcatcatcg tcaaagaaga agaaaacaaa ggtagaacat ggaggatcgt      120

caggctctaa acaaaattct g                                                141


<210>  232
<211>  127
<212>  DNA
<213>  Homo sapiens

<400>  232
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaaccagt tctgaatact cctctctcag attcaagtgg ttcaagaatg      120

ggaatga                                                                127


<210>  233
<211>  268
<212>  DNA
<213>  Homo sapiens

<400>  233
gggagctgtt caaaaaacga gctctttcta ctcctgtagt agaaaaacgt tcagcatctt       60

ctgagtcatc atcatcatcg tcaaagaaga agaaaacaaa ggtagaacat ggaggatcgt      120

caggctctaa acaaaattct gccttgcctc cccgattgaa agagatgaaa agccaggaat      180

cggctgcagg ttccaaacta gtccttcggt gtgaaaccag ttctgaatac tcctctctca      240

gattcaagtg gttcaagaat gggaatga                                         268


<210>  234
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  234

Glu Leu Phe Lys Lys Arg Ala Leu Ser Thr Pro Val Val Glu Lys Arg 
1               5                   10                  15      


Ser Ala Ser Ser Glu Ser Ser Ser Ser Ser Ser Lys Lys Lys Lys Thr 
            20                  25                  30          


Lys Val Glu His Gly Gly Ser Ser Gly Ser Lys Gln Asn Ser Ala Leu 
        35                  40                  45              


Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala Ala Gly Ser 
    50                  55                  60                  


Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser Ser Leu Arg 
65                  70                  75                  80  


Phe Lys Trp Phe Lys Asn Gly Asn 
                85              


<210>  235
<211>  264
<212>  DNA
<213>  Homo sapiens

<400>  235
actgagctcc tagcacccga tcgggaagtg gcgggcggag tcccgggtcc agtcgccgcc       60

tcagctaccg ccgctgccgc cgccgccgcc gccaccgcca gtggtgagac cccgacctgg      120

cgggtcagcg ctgggcgtgc gtgcgggcag gcgggggcgc tgacgagaag caggaagagg      180

gtgcagtgcc ggcgtgggcg gccggccgag gcggaggcgc aggaaggggg cggcgagtcg      240

tgcgaggctg cccttctcac tcag                                             264


<210>  236
<211>  170
<212>  DNA
<213>  Homo sapiens

<400>  236
cattatggat ccaagcctgt tgagagaaag ggagctgttc aaaaaacgag ctctttctac       60

tcctgtagta gaaaaacgtt cagcatcttc tgagtcatca tcatcatcgt caaagaagaa      120

gaaaacaaag gtagaacatg gaggatcgtc aggctctaaa caaaattctg                 170


<210>  237
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  237
atcatagcaa tggatcattt aacttgaaag ctttgtcagg aagctctgga tataagtttg       60

gtgttcttgc taagattgtg aattacatga ag                                     92


<210>  238
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  238
acacggcatc agcgaggaga tacgcatcct ctaaccttag atgaaatttt ggatgaaaca       60

caacatttag atattggact caagcagaaa caatggctaa tgactgag                   108


<210>  239
<211>  183
<212>  DNA
<213>  Homo sapiens

<400>  239
gctttagtca acaatcccaa aattgaagta atagatggga agtatgcttt caagcccaag       60

tacaacgtga gagataagaa ggccctactt aggctcttag atcagcatga ccagcgagga      120

ttaggaggaa ttcttttaga agacatagaa gaagcactgc ccaattccca gaaagctgtc      180

aag                                                                    183


<210>  240
<211>  94
<212>  DNA
<213>  Homo sapiens

<400>  240
gctttggggg accagatact atttgtaaat cgtcccgata agaagaaaat acttttcttc       60

aatgataaga gctgtcagtt ttctgtggat gaag                                   94


<210>  241
<211>  116
<212>  DNA
<213>  Homo sapiens

<400>  241
aatttcagaa actgtggagg agtgtcactg tagattccat ggacgaggag aaaattgaag       60

aatatctgaa gcgacagggt atttcttcca tgcaggaatc tggaccaaag aaagtg          116


<210>  242
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  242
gcccctattc agagaaggaa aaagcctgct tcacagaaaa agcgacgctt taagactcat       60

aacgaacact tggctggagt gctgaaggat tactctgaca ttacttccag caaataggga      120

acagttttgc cctggaacag agttacagat acacaatcaa gagtgttctt gctgatgctc      180

ggggtctgaa gactgtcttc ctatctgctt cttgcggctg aggagaggag cagttcagtt      240

tacaaaacaa gtgcaaatta ccaaactcaa agcttatttg agtagaatgg gctcatgggc      300

aatgtgatgt tccctgttaa ccttctgtta ctccctggga gaaaggcgct gagcgtggca      360

tgcaggtgtc tttgctgtgt ttttctccac ttctaaatgg ttcctggttc ctttcttcct      420

cgtttgttac tttagagcaa gtttgcccat agtcttgaat gcaatatttg tttattccaa      480

aagaacatat ttataataaa atcactgtag aaggattttt aagatgttag tgaattctgt      540

ttcttttcat tctcggaaat ggcaggaagc agctccagtc tctgatttcc atgggtcacg      600

tgctggggat gtgatgaagc ctgcagtctg cactgtgttg ctgagcacat ggatttcacc      660

actggaacac aggtgtgctg cttgttagca agcagagcaa taaagatgtg ctggatgtca      720


<210>  243
<211>  1747
<212>  DNA
<213>  Homo sapiens

<400>  243
actgagctcc tagcacccga tcgggaagtg gcgggcggag tcccgggtcc agtcgccgcc       60

tcagctaccg ccgctgccgc cgccgccgcc gccaccgcca gtggtgagac cccgacctgg      120

cgggtcagcg ctgggcgtgc gtgcgggcag gcgggggcgc tgacgagaag caggaagagg      180

gtgcagtgcc ggcgtgggcg gccggccgag gcggaggcgc aggaaggggg cggcgagtcg      240

tgcgaggctg cccttctcac tcagcattat ggatccaagc ctgttgagag aaagggagct      300

gttcaaaaaa cgagctcttt ctactcctgt agtagaaaaa cgttcagcat cttctgagtc      360

atcatcatca tcgtcaaaga agaagaaaac aaaggtagaa catggaggat cgtcaggctc      420

taaacaaaat tctgatcata gcaatggatc atttaacttg aaagctttgt caggaagctc      480

tggatataag tttggtgttc ttgctaagat tgtgaattac atgaagacac ggcatcagcg      540

aggagatacg catcctctaa ccttagatga aattttggat gaaacacaac atttagatat      600

tggactcaag cagaaacaat ggctaatgac tgaggcttta gtcaacaatc ccaaaattga      660

agtaatagat gggaagtatg ctttcaagcc caagtacaac gtgagagata agaaggccct      720

acttaggctc ttagatcagc atgaccagcg aggattagga ggaattcttt tagaagacat      780

agaagaagca ctgcccaatt cccagaaagc tgtcaaggct ttgggggacc agatactatt      840

tgtaaatcgt cccgataaga agaaaatact tttcttcaat gataagagct gtcagttttc      900

tgtggatgaa gaatttcaga aactgtggag gagtgtcact gtagattcca tggacgagga      960

gaaaattgaa gaatatctga agcgacaggg tatttcttcc atgcaggaat ctggaccaaa     1020

gaaagtggcc cctattcaga gaaggaaaaa gcctgcttca cagaaaaagc gacgctttaa     1080

gactcataac gaacacttgg ctggagtgct gaaggattac tctgacatta cttccagcaa     1140

atagggaaca gttttgccct ggaacagagt tacagataca caatcaagag tgttcttgct     1200

gatgctcggg gtctgaagac tgtcttccta tctgcttctt gcggctgagg agaggagcag     1260

ttcagtttac aaaacaagtg caaattacca aactcaaagc ttatttgagt agaatgggct     1320

catgggcaat gtgatgttcc ctgttaacct tctgttactc cctgggagaa aggcgctgag     1380

cgtggcatgc aggtgtcttt gctgtgtttt tctccacttc taaatggttc ctggttcctt     1440

tcttcctcgt ttgttacttt agagcaagtt tgcccatagt cttgaatgca atatttgttt     1500

attccaaaag aacatattta taataaaatc actgtagaag gatttttaag atgttagtga     1560

attctgtttc ttttcattct cggaaatggc aggaagcagc tccagtctct gatttccatg     1620

ggtcacgtgc tggggatgtg atgaagcctg cagtctgcac tgtgttgctg agcacatgga     1680

tttcaccact ggaacacagg tgtgctgctt gttagcaagc agagcaataa agatgtgctg     1740

gatgtca                                                               1747


<210>  244
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Asp Pro Ser Leu Leu Arg Glu Arg Glu Leu Phe Lys Lys Arg Ala 
1               5                   10                  15      


Leu Ser Thr Pro Val Val Glu Lys Arg Ser Ala Ser Ser Glu Ser Ser 
            20                  25                  30          


Ser Ser Ser Ser Lys Lys Lys Lys Thr Lys Val Glu His Gly Gly Ser 
        35                  40                  45              


Ser Gly Ser Lys Gln Asn Ser 
    50                  55  


<210>  245
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  245

His Ser Asn Gly Ser Phe Asn Leu Lys Ala Leu Ser Gly Ser Ser Gly 
1               5                   10                  15      


Tyr Lys Phe Gly Val Leu Ala Lys Ile Val Asn Tyr Met Lys 
            20                  25                  30  


<210>  246
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  246

Thr Arg His Gln Arg Gly Asp Thr His Pro Leu Thr Leu Asp Glu Ile 
1               5                   10                  15      


Leu Asp Glu Thr Gln His Leu Asp Ile Gly Leu Lys Gln Lys Gln Trp 
            20                  25                  30          


Leu Met Thr Glu 
        35      


<210>  247
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  247

Ala Leu Val Asn Asn Pro Lys Ile Glu Val Ile Asp Gly Lys Tyr Ala 
1               5                   10                  15      


Phe Lys Pro Lys Tyr Asn Val Arg Asp Lys Lys Ala Leu Leu Arg Leu 
            20                  25                  30          


Leu Asp Gln His Asp Gln Arg Gly Leu Gly Gly Ile Leu Leu Glu Asp 
        35                  40                  45              


Ile Glu Glu Ala Leu Pro Asn Ser Gln Lys Ala Val Lys 
    50                  55                  60      


<210>  248
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  248

Ala Leu Gly Asp Gln Ile Leu Phe Val Asn Arg Pro Asp Lys Lys Lys 
1               5                   10                  15      


Ile Leu Phe Phe Asn Asp Lys Ser Cys Gln Phe Ser Val Asp Glu 
            20                  25                  30      


<210>  249
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  249

Phe Gln Lys Leu Trp Arg Ser Val Thr Val Asp Ser Met Asp Glu Glu 
1               5                   10                  15      


Lys Ile Glu Glu Tyr Leu Lys Arg Gln Gly Ile Ser Ser Met Gln Glu 
            20                  25                  30          


Ser Gly Pro Lys Lys Val 
        35              


<210>  250
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  250

Ala Pro Ile Gln Arg Arg Lys Lys Pro Ala Ser Gln Lys Lys Arg Arg 
1               5                   10                  15      


Phe Lys Thr His Asn Glu His Leu Ala Gly Val Leu Lys Asp Tyr Ser 
            20                  25                  30          


Asp Ile Thr Ser Ser Lys 
        35              


<210>  251
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Asp Pro Ser Leu Leu Arg Glu Arg Glu Leu Phe Lys Lys Arg Ala 
1               5                   10                  15      


Leu Ser Thr Pro Val Val Glu Lys Arg Ser Ala Ser Ser Glu Ser Ser 
            20                  25                  30          


Ser Ser Ser Ser Lys Lys Lys Lys Thr Lys Val Glu His Gly Gly Ser 
        35                  40                  45              


Ser Gly Ser Lys Gln Asn Ser Asp His Ser Asn Gly Ser Phe Asn Leu 
    50                  55                  60                  


Lys Ala Leu Ser Gly Ser Ser Gly Tyr Lys Phe Gly Val Leu Ala Lys 
65                  70                  75                  80  


Ile Val Asn Tyr Met Lys Thr Arg His Gln Arg Gly Asp Thr His Pro 
                85                  90                  95      


Leu Thr Leu Asp Glu Ile Leu Asp Glu Thr Gln His Leu Asp Ile Gly 
            100                 105                 110         


Leu Lys Gln Lys Gln Trp Leu Met Thr Glu Ala Leu Val Asn Asn Pro 
        115                 120                 125             


Lys Ile Glu Val Ile Asp Gly Lys Tyr Ala Phe Lys Pro Lys Tyr Asn 
    130                 135                 140                 


Val Arg Asp Lys Lys Ala Leu Leu Arg Leu Leu Asp Gln His Asp Gln 
145                 150                 155                 160 


Arg Gly Leu Gly Gly Ile Leu Leu Glu Asp Ile Glu Glu Ala Leu Pro 
                165                 170                 175     


Asn Ser Gln Lys Ala Val Lys Ala Leu Gly Asp Gln Ile Leu Phe Val 
            180                 185                 190         


Asn Arg Pro Asp Lys Lys Lys Ile Leu Phe Phe Asn Asp Lys Ser Cys 
        195                 200                 205             


Gln Phe Ser Val Asp Glu Glu Phe Gln Lys Leu Trp Arg Ser Val Thr 
    210                 215                 220                 


Val Asp Ser Met Asp Glu Glu Lys Ile Glu Glu Tyr Leu Lys Arg Gln 
225                 230                 235                 240 


Gly Ile Ser Ser Met Gln Glu Ser Gly Pro Lys Lys Val Ala Pro Ile 
                245                 250                 255     


Gln Arg Arg Lys Lys Pro Ala Ser Gln Lys Lys Arg Arg Phe Lys Thr 
            260                 265                 270         


His Asn Glu His Leu Ala Gly Val Leu Lys Asp Tyr Ser Asp Ile Thr 
        275                 280                 285             


Ser Ser Lys 
    290     


<210>  252
<211>  434
<212>  DNA
<213>  Homo sapiens

<400>  252
actgagctcc tagcacccga tcgggaagtg gcgggcggag tcccgggtcc agtcgccgcc       60

tcagctaccg ccgctgccgc cgccgccgcc gccaccgcca gtggtgagac cccgacctgg      120

cgggtcagcg ctgggcgtgc gtgcgggcag gcgggggcgc tgacgagaag caggaagagg      180

gtgcagtgcc ggcgtgggcg gccggccgag gcggaggcgc aggaaggggg cggcgagtcg      240

tgcgaggctg cccttctcac tcagcattat ggatccaagc ctgttgagag aaagggagct      300

gttcaaaaaa cgagctcttt ctactcctgt agtagaaaaa cgttcagcat cttctgagtc      360

atcatcatca tcgtcaaaga agaagaaaac aaaggtagaa catggaggat cgtcaggctc      420

taaacaaaat tctg                                                        434


<210>  253
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  253
atcctaaaca gcacatccaa tcacctgtgg ctagagttca acaccaatgg atctgacacc       60

gaccaaggtt ttcaactcac ctatacca                                          88


<210>  254
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  254
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ct                                                                      62


<210>  255
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  255
atcctaaaca gcacatccaa tcacctgtgg ctagagttca acaccaatgg atctgacacc       60

gaccaaggtt ttcaactcac ctataccact acatctacat ccaccactgg gacaagccat      120

cttgtaaaat gtgcggagaa ggagaaaact                                       150


<210>  256
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  256

Ile Leu Asn Ser Thr Ser Asn His Leu Trp Leu Glu Phe Asn Thr Asn 
1               5                   10                  15      


Gly Ser Asp Thr Asp Gln Gly Phe Gln Leu Thr Tyr Thr Thr Thr Ser 
            20                  25                  30          


Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu 
        35                  40                  45              


Lys Thr 
    50  


<210>  257
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  257
ctccacggca gcggctcctt gtgccactag cagcccttct tctgcgctct ccgccttttc       60

tctctagact ggatctctcc tcccccccgc gcccccctcc ccgcatctcc cactcgctgg      120

ctctctctcc agctgcctcc tctccaggtc tctcctggct gcgcgcgctc ctctccccgc      180

ttctccccct cccgcagcct cgccgccttg gtgccttcct gcccggctcg gccggcgctc      240

gtccccggcc ccggccccgc cagcccgggt ctccgcgctc ggagcagctc agccctgcag      300

tggctcggga cccgatgcta tgagagggaa gcgagccggg cgcccagacc ttcaggaggc      360

gtcggatgcg cggcgggtct tgggaccggg ctctctctcc ggctcgcctt gccctcgggt      420

gattatttgg ctccgctcat agccctgcct tcctcggagg agccatcggt gtcgcgtgcg      480

tgtggagtat ctgcagacat gactgcgtgg aggagattcc agtcgctgct cctgcttctc      540

gggctgctgg tgctgtgcgc gaggctcctc actgcagcga agg                        583


<210>  258
<211>  217
<212>  DNA
<213>  Homo sapiens

<400>  258
gtcagaactg tggaggctta gtccagggtc ccaatggcac tattgagagc ccagggtttc       60

ctcacgggta tccgaactat gccaactgca cctggatcat catcacgggc gagcgcaata      120

ggatacagtt gtccttccat acctttgctc ttgaagaaga ttttgatatt ttatcagttt      180

acgatggaca gcctcaacaa gggaatttaa aagtgag                               217


<210>  259
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  259
attatcggga tttcagctgc cctcctctat agtgagtaca ggatctatcc tcactctgtg       60

gttcacgaca gacttcgctg tgagtgccca aggtttcaaa gcattatatg aag             113


<210>  260
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  260
ttttacctag ccacacttgt ggaaatcctg gagaaatcct gaaaggagtt ctgcatggaa       60

cgagattcaa cataggagac aaaatccggt acagctgcct ccctggctac atcttggaag      120

gccacgccat cctgacctgc atcgtcagcc caggaaatgg tgcatcgtgg gacttcccag      180

ctcccttttg cagag                                                       195


<210>  261
<211>  208
<212>  DNA
<213>  Homo sapiens

<400>  261
ctgagggagc ctgcggagga accttacgcg ggaccagcag ctccatctcc agcccgcact       60

tcccttcaga gtacgagaac aacgcggact gcacctggac cattctggct gagcccgggg      120

acaccattgc gctggtcttc actgactttc agctagaaga aggatatgat ttcttagaga      180

tcagtggcac ggaagctcca tccatatg                                         208


<210>  262
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  262
gctaactggc atgaacctcc cctctccagt tatcagtagc aagaattggc tacgactcca       60

tttcacctct gacagcaacc accgacgcaa aggatttaac gctcagttcc aag             113


<210>  263
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  263
tgaaaaaggc gattgagttg aagtcaagag gagtcaagat gctgcccagc aaggatggaa       60

gccataaaaa ctctgtct                                                     78


<210>  264
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  264
tgagccaagg aggtgttgca ttggtctctg acatgtgtcc agatcctggg attccagaaa       60

atggtagaag agcaggttcc gacttcag                                          88


<210>  265
<211>  125
<212>  DNA
<213>  Homo sapiens

<400>  265
ggttggtgca aatgtacagt tttcatgtga ggacaattac gtgctccagg gatctaaaag       60

catcacctgt cagagagtta cagagacgct cgctgcttgg agtgaccaca ggcccatctg      120

ccgag                                                                  125


<210>  266
<211>  122
<212>  DNA
<213>  Homo sapiens

<400>  266
cgagaacatg tggatccaat ctgcgtgggc ccagcggcgt cattacctcc cctaattatc       60

cggttcagta tgaagataat gcacactgtg tgtgggtcat caccaccacc gacccggaca      120

ag                                                                     122


<210>  267
<211>  104
<212>  DNA
<213>  Homo sapiens

<400>  267
gtcatcaagc ttgcctttga agagtttgag ctggagcgag gctatgacac cctgacggtt       60

ggtgatgctg ggaaggtggg agacaccaga tcggtcttgt acgt                       104


<210>  268
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  268
gctcacggga tccagtgttc ctgacctcat tgtgagcatg agcaaccaga tgtggctaca       60

tctgcagtcg gatgatagca ttggctcacc tgggtttaaa gctgtttacc aag             113


<210>  269
<211>  183
<212>  DNA
<213>  Homo sapiens

<400>  269
aaattgaaaa gggagggtgt ggggatcctg gaatccccgc ctatgggaag cggacgggca       60

gcagtttcct ccatggagat acactcacct ttgaatgccc ggcggccttt gagctggtgg      120

gggagagagt tatcacctgt cagcagaaca atcagtggtc tggcaacaag cccagctgtg      180

tat                                                                    183


<210>  270
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  270
tttcatgttt cttcaacttt acggcatcat ctgggattat tctgtcacca aattatccag       60

aggaatatgg gaacaacatg aactgtgtct ggttgattat ctcggagcca ggaagtcgaa      120

ttcacctaat ctttaatgat tttgatgttg agcctcagtt tgactttctc gcggtcaagg      180

atgatggcat ttctgacata actgtcctgg gtactttttc tggcaatgaa gtgccttccc      240

agctggccag cagtgggcat atagttcgct tggaatttca gtctgaccat tccactactg      300

gcagagggtt caacatcact tacacca                                          327


<210>  271
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  271
catttggtca gaatgagtgc catgatcctg gcattcctat aaacggacga cgttttggtg       60

acaggtttct actcgggagc tcggtttctt tccactgtga tgatggcttt gtcaagaccc      120

agggatccga gtccattacc tgcatactgc aagacgggaa cgtggtctgg agctccaccg      180

tgccccgctg tgaag                                                       195


<210>  272
<211>  139
<212>  DNA
<213>  Homo sapiens

<400>  272
ctccatgtgg tggacatctg acagcgtcca gcggagtcat tttgcctcct ggatggccag       60

gatattataa ggattcttta cattgtgaat ggataattga agcaaaacca ggccactcta      120

tcaaaataac ttttgacag                                                   139


<210>  273
<211>  188
<212>  DNA
<213>  Homo sapiens

<400>  273
atttcagaca gaggtcaatt atgacacctt ggaggtcaga gatgggccag ccagttcgtc       60

cccactgatc ggcgagtacc acggcaccca ggcaccccag ttcctcatca gcaccgggaa      120

cttcatgtac ctgctgttca ccactgacaa cagccgctcc agcatcggct tcctcatcca      180

ctatgaga                                                               188


<210>  274
<211>  189
<212>  DNA
<213>  Homo sapiens

<400>  274
gtgtgacgct tgagtcggat tcctgcctgg acccgggcat ccctgtgaac ggccatcgcc       60

acggtggaga ctttggcatc aggtccacag tgactttcag ctgtgacccg gggtacacac      120

taagtgacga cgagcccctc gtctgtgaga ggaaccacca gtggaaccac gccttgccca      180

gctgcgacg                                                              189


<210>  275
<211>  117
<212>  DNA
<213>  Homo sapiens

<400>  275
ctctatgtgg aggctacatc caagggaaga gtggaacagt cctttctcct gggtttccag       60

atttttatcc aaactctcta aactgcacgt ggaccattga agtgtctcat gggaaag         117


<210>  276
<211>  216
<212>  DNA
<213>  Homo sapiens

<400>  276
gagttcaaat gatctttcac acctttcatc ttgagagttc ccacgactat ttactgatca       60

cagaggatgg aagtttttcc gagcccgttg ccaggctcac cgggtcggtg ttgcctcata      120

cgatcaaggc aggcctgttt ggaaacttca ctgcccagct tcggtttata tcagacttct      180

caatttcgta cgagggcttc aatatcacat tttcag                                216


<210>  277
<211>  189
<212>  DNA
<213>  Homo sapiens

<400>  277
aatatgacct ggagccatgt gatgatcctg gagtccctgc cttcagccga agaattggtt       60

ttcactttgg tgtgggagac tctctgacgt tttcctgctt cctgggatat cgtttagaag      120

gtgccaccaa gcttacctgc ctgggtgggg gccgccgtgt gtggagtgca cctctgccaa      180

ggtgtgtgg                                                              189


<210>  278
<211>  170
<212>  DNA
<213>  Homo sapiens

<400>  278
ccgaatgtgg agcaagtgtc aaaggaaatg aaggaacatt actgtctcca aattttccat       60

ccaattatga taataaccat gagtgtatct ataaaataga aacagaagcc ggcaagggca      120

tccaccttag aacacgaagc ttccagctgt ttgaaggaga tactctaaag                 170


<210>  279
<211>  157
<212>  DNA
<213>  Homo sapiens

<400>  279
gtatatgatg gaaaagacag ttcctcacgt ccactgggca cgttcactaa aaatgaactt       60

ctggggctga tcctaaacag cacatccaat cacctgtggc tagagttcaa caccaatgga      120

tctgacaccg accaaggttt tcaactcacc tatacca                               157


<210>  280
<211>  192
<212>  DNA
<213>  Homo sapiens

<400>  280
gttttgatct ggtaaaatgt gaggatccgg gcatccctaa ctacggctat aggatccgtg       60

atgaaggcca ctttaccgac actgtagttc tgtacagttg caacccgggg tacgccatgc      120

atggcagcaa caccctgacc tgtttgagtg gagacaggag agtgtgggac aaaccactac      180

cttcgtgcat ag                                                          192


<210>  281
<211>  10288
<212>  DNA
<213>  Homo sapiens

<400>  281
gttttgatct ggtaaaatgt gaggatccgg gcatccctaa ctacggctat aggatccgtg       60

atgaaggcca ctttaccgac actgtagttc tgtacagttg caacccgggg tacgccatgc      120

atggcagcaa caccctgacc tgtttgagtg gagacaggag agtgtgggac aaaccactac      180

cttcgtgcat agcggaatgt ggtggtcaga tccatgcagc cacatcagga cgaatattgt      240

cccctggcta tccagctccg tatgacaaca acctccactg cacctggatt atagaggcag      300

acccaggaaa gaccattagc ctccatttca ttgttttcga cacggagatg gctcacgaca      360

tcctcaaggt ctgggacggg ccggtggaca gtgacatcct gctgaaggag tggagtggct      420

ccgcccttcc ggaggacatc cacagcacct tcaactcact caccctgcag ttcgacagcg      480

acttcttcat cagcaagtct ggcttctcca tccagttctc cacctcaatt gcagccacct      540

gtaacgatcc aggtatgccc caaaatggca cccgctatgg agacagcaga gaggctggag      600

acaccgtcac attccagtgt gaccctggct atcagctcca aggacaagcc aaaatcacct      660

gtgtgcagct gaataaccgg ttcttttggc aaccagaccc tcctacatgc atagctgctt      720

gtggagggaa tctgacgggc ccagcaggtg ttattttgtc acccaactac ccacagccgt      780

atcctcctgg gaaggaatgt gactggagag taaaagtgaa cccggacttt gtcatcgcct      840

tgatattcaa aagtttcaac atggagccca gctatgactt cctacacatc tatgaagggg      900

aagattccaa cagccccctc attgggagtt accagggctc tcaggcccca gaaagaatag      960

agagtagcgg aaacagcctg tttctggcat ttcggagtga tgcctccgtg ggcctttcag     1020

ggttcgccat tgaatttaaa gagaaaccac gggaagcttg ttttgaccca ggaaatataa     1080

tgaatgggac aagagttgga acagacttca agcttggctc caccatcacc taccagtgtg     1140

actctggcta taagattctt gacccctcat ccatcacctg tgtgattggg gctgatggga     1200

aaccctcctg ggaccaagtg ctgccctcct gcaatgctcc ctgtggaggc cagtacacgg     1260

gatcagaagg ggtagtttta tcaccaaact acccccataa ttacacagct ggtcaaatat     1320

gcctctattc catcacggta ccaaaggaat tcgtggtctt tggacagttt gcctatttcc     1380

agacagccct gaatgatttg gcagaattat ttgatggaac ccatgcacag gccagacttc     1440

tcagctcact ctcggggtct cactcagggg aaacattgcc cttggctacg tcaaatcaaa     1500

ttctgctccg attcagtgca aagagcggtg cctctgcccg cggcttccac ttcgtgtatc     1560

aagctgttcc tcgtaccagt gacacccaat gcagctctgt ccccgagccc agatacggaa     1620

ggagaattgg ttctgagttt tctgccggct ccatcgtccg attcgagtgc aacccgggat     1680

acctgcttca gggttccacg gcgctccact gccagtccgt gcccaacgcc ttggcacagt     1740

ggaacgacac gatccccagc tgtgtggtac cctgcagtgg caatttcact caacgaagag     1800

gtacaatcct gtcccccggc taccctgagc catacggaaa caacttgaac tgtatatgga     1860

agatcatagt tacggagggc tcgggaattc agatccaagt gatcagtttt gccacggagc     1920

agaactggga ctcccttgag atccacgatg gtggggatgt gaccgcaccc agactgggaa     1980

gcttctcagg caccacagta ccggcactgc tgaacagtac ttccaaccaa ctctacctgc     2040

atttccagtc tgacattagt gtggcagctg ctggtttcca cctggaatac aaaactgtag     2100

gtcttgctgc atgccaagaa ccagccctcc ccagcaacag catcaaaatc ggagatcggt     2160

acatggtgaa cgacgtgctc tccttccagt gcgagcccgg gtacaccctg cagggccgtt     2220

cccacatttc ctgtatgcca gggaccgttc gccgttggaa ctatccgtct cccctgtgca     2280

ttgcaacctg tggagggacg ctgagcacct tgggtggtgt gatcctgagc cccggcttcc     2340

caggttctta ccccaacaac ttagactgca cctggaggat ctcattaccc atcggctatg     2400

gtgcacatat tcagtttctg aatttttcta ccgaagctaa tcatgacttc cttgaaattc     2460

aaaatggacc ttaccacacc agccccatga ttggacaatt tagcggcacg gatctccccg     2520

cggccctgct gagcacaacg catgaaaccc tcatccactt ttatagtgac cattcgcaaa     2580

accggcaagg atttaaactt gcttaccaag cctatgaatt acagaactgt ccagatccac     2640

ccccatttca gaatgggtac atgatcaact cggattacag cgtggggcaa tcagtatctt     2700

tcgagtgtta tcctgggtac attctaatag gccatcctgt cctcacttgt cagcatggga     2760

tcaacagaaa ctggaactac ccttttccaa gatgtgatgc cccttgtggg tacaacgtaa     2820

cttctcagaa cggcaccatc tactcccctg gctttcctga tgagtatccg atcctgaagg     2880

actgcatttg gctcatcacg gtgcctccag ggcacggagt ttacatcaac ttcaccctgt     2940

tacagacgga agctgtcaac gattacattg ctgtttggga cggtcccgat cagaactcac     3000

cccagctggg agttttcagt ggcaacacag ccctcgaaac ggcgtatagc tccaccaacc     3060

aagtcctgct caagttccac agcgactttt caaatggagg cttctttgtc ctcaatttcc     3120

acgcatttca gctcaagaaa tgtcaacctc ccccagcggt tccacaggca gaaatgctta     3180

ctgaggatga tgatttcgaa ataggagatt ttgtgaagta ccagtgccac cccgggtaca     3240

ccttggtggg gaccgacatt ctgacttgca agctcagttc ccagttgcag tttgagggtt     3300

ctctcccaac atgtgaagca caatgcccag caaatgaagt ccggactgga tcatcgggag     3360

tcattctcag tccagggtat ccgggtaatt attttaactc ccagacttgc tcttggagta     3420

ttaaagtgga accaaactac aacattacca tctttgtgga cacatttcaa agtgaaaagc     3480

agtttgatgc actggaagtg tttgatggtt cttctgggca aagtcctctg ctagtagtct     3540

taagtgggaa tcatactgaa caatcaaatt ttacaagcag gagtaatcag ttatatctcc     3600

gctggtccac tgaccatgcc accagtaaga aaggattcaa gattcgctat gcagcacctt     3660

actgcagttt gacccacccc ctgaagaatg ggggtattct aaacaggact gcaggagcgg     3720

ttggaagcaa agtgcattat ttttgcaagc ctggataccg aatggtcggc cacagcaatg     3780

caacctgtag acgaaaccca cttggcatgt accagtggga ctccctcacg ccactctgcc     3840

aggctgtgtc ctgtggaatc ccagaatccc caggaaacgg ttcatttacc gggaacgagt     3900

tcactttgga cagtaaagtg gtctatgaat gtcatgaggg cttcaagctt gaatccagcc     3960

agcaagcaac agccgtgtgt caagaagatg ggttgtggag taacaagggg aagccgccca     4020

cgtgtaagcc ggtcgcttgc cccagcattg aagctcagct ctcagaacat gtcatctgga     4080

ggctggtttc aggatccttg aatgagtacg gtgctcaagt attgctgagc tgcagtcctg     4140

gttactactt agaaggctgg aggctcctgc ggtgccaggc caatgggacg tggaacatag     4200

gagatgagag gccaagctgt cgagttatct cgtgtggaag cctttccttt cccccaaatg     4260

gcaacaagat tggaacgttg acagtttatg gggccacagc tatatttacg tgcaacaccg     4320

gctacacgct tgtggggtct catgtcagag agtgcttggc aaatgggctc tggagcggca     4380

gcgaaactcg atgtctggct ggccactgcg gttccccaga cccgattgtg aacggtcaca     4440

ttagtggaga tggcttcagt tacagagaca cggtggttta ccagtgcaat cctggtttcc     4500

ggcttgtggg aacttccgtg aggatatgcc tgcaagacca caagtggtct ggacaaacgc     4560

ctgtctgtgt ccccatcaca tgtggtcacc ctggaaaccc tgcccacgga ttcactaatg     4620

gcagtgagtt caacctgaat gatgtcgtga atttcacctg caacacgggc tatttgctgc     4680

agggcgtgtc tcgagcccag tgtcggagca acggccagtg gagtagccct ctgcccacgt     4740

gtcgagtggt gaactgttct gatccaggct ttgtggaaaa tgccattcgt cacgggcaac     4800

agaacttccc tgagagtttt gagtatggaa tgagtatcct gtaccattgc aagaagggat     4860

tttacttgct gggatcttca gccttgacct gtatggcaaa tggcttatgg gaccgatccc     4920

tgcccaagtg tttggctata tcgtgtggac acccaggggt ccctgccaac gccgtcctca     4980

ctggagagct gtttacctat ggcgccgtcg tgcactactc ctgcagaggg agcgagagcc     5040

tcataggcaa cgacacgaga gtgtgccagg aagacagtca ctggagcggg gcactgcccc     5100

actgcacagg aaataatcct ggattctgtg gtgatccggg gaccccagca catgggtctc     5160

ggcttggtga tgactttaag acaaagagtc ttctccgctt ctcctgtgaa atggggcacc     5220

agctgagggg ctcccctgaa cgcacgtgtt tgctcaatgg gtcatggtca ggactgcagc     5280

cggtgtgtga ggccgtgtcc tgtggcaacc ctggcacacc caccaacgga atgattgtca     5340

gtagtgatgg cattctgttc tccagctcgg tcatctatgc ctgctgggaa ggctacaaga     5400

cctcagggct catgacacgg cattgcacag ccaatgggac ctggacaggc actgctcccg     5460

actgcacaat tataagttgt ggggatccag gcacactagc aaatggcatc cagtttggga     5520

ccgacttcac cttcaacaag actgtgagct atcagtgtaa cccaggctat gtcatggaag     5580

cagtcacatc cgccactatt cgctgtacca aagacggcag gtggaatccg agcaaacctg     5640

tctgcaaagc cgtgctgtgt cctcagccgc cgccggtgca gaatggaaca gtggagggaa     5700

gtgatttccg ctggggctcc agcataagtt acagctgcat ggacggttac cagctctctc     5760

actccgccat cctctcctgt gaaggtcgcg gggtgtggaa aggagagatc ccccagtgtc     5820

tccctgtgtt ctgcggagac cctggcatcc ccgcagaagg gcgacttagt gggaaaagtt     5880

tcacctataa gtccgaagtc ttcttccagt gcaaatctcc atttatactc gtgggatcct     5940

ccagaagagt ctgccaagct gacggcacgt ggagcggcat acaacccacc tgcattgatc     6000

ctgctcataa cacctgccca gaccctggta cgccacactt tggaatacag aatagctcca     6060

gaggctatga ggttggaagc acggtttttt tcaggtgcag aaaaggctac catattcaag     6120

gttccacgac tcgcacctgc cttgccaatt taacatggag tgggatacag accgaatgta     6180

tacctcatgc ctgcagacag ccagaaaccc cggcacacgc ggatgtgaga gccatcgatc     6240

ttcctacttt cggctacacc ttagtgtaca cctgccatcc aggctttttc ctcgcagggg     6300

gatctgagca cagaacatgt aaagcagaca tgaaatggac aggaaagtcg cctgtgtgta     6360

aaagtaaagg agtgagagaa gttaatgaaa cagttactaa aactccagtt ccttcagatg     6420

tctttttcgt caattcactg tggaaggggt attatgaata tttagggaaa agacaacccg     6480

ccactctaac tgttgactgg ttcaatgcaa caagcagtaa ggtgaatgcc accttcagcg     6540

aagcctcgcc agtggagctg aagttgacag gcatttacaa gaaggaggag gcccacttac     6600

tcctgaaagc ttttcaaatt aaaggccagg cagatatttt tgtaagcaag ttcgaaaatg     6660

acaactgggg actagatggt tatgtgtcat ctggacttga aagaggagga tttacttttc     6720

aaggtgacat tcatggaaaa gactttggaa aatttaagct agaaaggcaa gatcctttaa     6780

acccagatca agactcttcc agtcattacc acggcaccag cagtggctct gtggcggctg     6840

ccattctggt tcctttcttt gctctaattt tatcagggtt tgcattttac ctctacaaac     6900

acagaacgag accaaaagtt caatacaatg gctatgctgg gcatgaaaac agcaatggac     6960

aagcatcgtt tgaaaacccc atgtatgata caaacttaaa acccacagaa gccaaggctg     7020

tgaggtttga cacaactctg aacacagtct gtacagtggt atagccctca gtgccccaac     7080

aggactgatt catagccata cctctgatgg acaagcagtg attcctttgg tgccatatac     7140

cactctccct tccactctgg ctttactgca gcgatcttca accttgtcta ctggcataag     7200

tgcagcgggg atctctactc aaatgtgtca gggtcttcta cggatcaaac tacacatgcg     7260

ttttcattcc aaaagtgggt tctaaatgcc tggctgcatc tgtatgaaat caaggcacac     7320

tccaggaaga ctgccacgtc gcgccaacac gtcatactca atgcctcaga ctttcatatt     7380

tctgtgttgc tgagatgcct ttcaatgcaa tcgtctgggc tcgtggatat gtccctcagg     7440

tgcggtgaca gaatggtggc accacgatat gtgttctctt gtgttgtttt tcctttttaa     7500

acccccatga acacgaatac tctgaaaaaa ataaaaagct ttctggaaga agacaccttt     7560

ctgatagagg ctcacaccta caaatgcttc actctgtcct tccgagacct gacaagcttt     7620

gaggacctca cagctcccct gtgtgttcat ctctagggat gtttgcaatt tcccagtcag     7680

ctgttctgtc gcagaatgtt taatgcacaa ttttttgcac tagtgtgtta tgaatgacta     7740

agattctgat aaaaaaaata aattatttac acagggttta tacacactat ccattgtata     7800

taagcattat ttcatattat caagctaaac attcccccat cagcttagtt ggagtgttag     7860

ggaaaagtat tcctagatat ggcacagatt ttaaaaggaa atacagtatt gaagagattt     7920

attttattat tgcttcaatt agctccattt acgtgttgaa ttcattgaag aggtccaatg     7980

agaaaaaaac agaagcctcc ttatttcaca cgttttcctc ctttagtacc atcctcatcc     8040

aattactgtc tctctgatac tacttaatag cagggggttt gcagaaattt ctgtttgcca     8100

tgtaaaactg tgaatagtaa tttattttag atagtcgatg aacttgtggg ttttagctca     8160

caatgcagcc ttcccttttg cagtgttttt tttttgtttt tttttttttt tgtcttttac     8220

tgtgccatcg atctttgata ttgcattgaa agacaatata ccacagtagc accttgaact     8280

cagtgaaaat tgttcaggat caaaatacca agtgttcttt tagagggaag gaaaaagtac     8340

acacactctc ctctcacaat gatatatttt atacattcat ttgttatttg tttcatgctt     8400

tatgattcca gatggaaagg taatttcagt gacttttcaa gtttaaattc cattataggt     8460

aaatgataag ttatgatgca aataaaatct ataagatccc cagggcaaat aaaaatcaaa     8520

acatgaagta gaagatgtgg ccgtgaggta gtttatgtaa caaattcaaa gtgaaaatca     8580

tgtttacttt tacttatact tatttgataa aaatattttt gaaacgatag tacttatttt     8640

attatttgat atttcagttc ctattcaatt gtggcagatt ttctctgttt cacattttag     8700

attggcgttg gtaatagaaa tgtcagaatg ttcaaattgg ccttcacgtt gtcggagtga     8760

acacattgac acctagcttt aagactgatt tatctgttgg tgtactgaag gtttccatgt     8820

aggacttcaa atgtggaaaa ggaaaagcag tcaggaaaat ggggcattct ttggagagtc     8880

acgcgttttg attcggacat ttccgtagag ctcggctccc agtgttgtgt tcctcggtcg     8940

aaagggtctc tgctgtttgg ggactcactg gcctctccta gggactcctt tgtcttgtga     9000

accccacgct gttggattct gtatcattat gctgaattct ctgcacagtt ttccctggcc     9060

aacctgccca catccttgga gatttgcttt gccagtggga atccttacat tgctgtttca     9120

cagtagacgg gacgaggtca gcgggagtcg tgctcctaac acacacattg aacgaaacag     9180

aagatgattg aaagtgtgag gaggctcgtg tgcaagggag aacagggtta ctatacatat     9240

tagtgtatat atatacatac atatatatat atatatattg tacatatcta agtttgagtc     9300

attcaaacta ggtgcaaaat gctgacttca gagtctgaat taacatctct gttcccatat     9360

ccctgacctg ctccctggtc aacgatgcta tgaaatcctg aaatgacagg acatacatac     9420

atacaagaaa ccacatatca aattagatat gattttcctt tgtgtgcaaa gtcaaactgt     9480

cctagggttg ccagtttgaa gcatgttatt taaatgaaaa aaaaaatcag tgaaattctc     9540

gtgtgagaat tctgcctagt ttcttcctaa ggttgtgtgc agtgttgaac ggcgtctccg     9600

caaggtgttg gaggatctca ttttagggca gtcaggagct gtgcttgctg agttaggtct     9660

agaagactct tccctgaagg caacgggaac acgcgtgagg gacgcgacca cacactaaca     9720

gaggacacgt gcttcagagc tgtttaaaac tgctgcttgt tttacacaca catcttgcct     9780

tttttcaggc tagctgcaat aatttttttc ttctgtaaaa tattttgtaa acaacaacaa     9840

aaagctatta taaaaagggg gtaaaaaaaa gaacgctggc attatgatca ggaaaaccca     9900

ttgtcatcgc cgaccctccc tcccgtccca ccacacgctg ctgtcacgac gtaggtgcga     9960

aagacctttt tgtacagaga tatatttttt atgaagaatt tgtaaaatta ttaaatatgc    10020

tgtaattttt tgattaatgt aggtacattg ttaaaaaata aatgttttta caatacagaa    10080

ctgtaatttt cccaataatg taaaatgtac catctctagc tgattttcag ttccaatcct    10140

attacacatg tattaatatt aaagtggcct gttaaaatga acagtatctt ttttttgtca    10200

aaaaaattat aaagagggtg taatatagcc tgtgcaatgc caccaatctt taaagcaaat    10260

cagagttcta attaaatatt taatttta                                       10288


<210>  282
<211>  14417
<212>  DNA
<213>  Homo sapiens

<400>  282
ctccacggca gcggctcctt gtgccactag cagcccttct tctgcgctct ccgccttttc       60

tctctagact ggatctctcc tcccccccgc gcccccctcc ccgcatctcc cactcgctgg      120

ctctctctcc agctgcctcc tctccaggtc tctcctggct gcgcgcgctc ctctccccgc      180

ttctccccct cccgcagcct cgccgccttg gtgccttcct gcccggctcg gccggcgctc      240

gtccccggcc ccggccccgc cagcccgggt ctccgcgctc ggagcagctc agccctgcag      300

tggctcggga cccgatgcta tgagagggaa gcgagccggg cgcccagacc ttcaggaggc      360

gtcggatgcg cggcgggtct tgggaccggg ctctctctcc ggctcgcctt gccctcgggt      420

gattatttgg ctccgctcat agccctgcct tcctcggagg agccatcggt gtcgcgtgcg      480

tgtggagtat ctgcagacat gactgcgtgg aggagattcc agtcgctgct cctgcttctc      540

gggctgctgg tgctgtgcgc gaggctcctc actgcagcga agggtcagaa ctgtggaggc      600

ttagtccagg gtcccaatgg cactattgag agcccagggt ttcctcacgg gtatccgaac      660

tatgccaact gcacctggat catcatcacg ggcgagcgca ataggataca gttgtccttc      720

catacctttg ctcttgaaga agattttgat attttatcag tttacgatgg acagcctcaa      780

caagggaatt taaaagtgag attatcggga tttcagctgc cctcctctat agtgagtaca      840

ggatctatcc tcactctgtg gttcacgaca gacttcgctg tgagtgccca aggtttcaaa      900

gcattatatg aagttttacc tagccacact tgtggaaatc ctggagaaat cctgaaagga      960

gttctgcatg gaacgagatt caacatagga gacaaaatcc ggtacagctg cctccctggc     1020

tacatcttgg aaggccacgc catcctgacc tgcatcgtca gcccaggaaa tggtgcatcg     1080

tgggacttcc cagctccctt ttgcagagct gagggagcct gcggaggaac cttacgcggg     1140

accagcagct ccatctccag cccgcacttc ccttcagagt acgagaacaa cgcggactgc     1200

acctggacca ttctggctga gcccggggac accattgcgc tggtcttcac tgactttcag     1260

ctagaagaag gatatgattt cttagagatc agtggcacgg aagctccatc catatggcta     1320

actggcatga acctcccctc tccagttatc agtagcaaga attggctacg actccatttc     1380

acctctgaca gcaaccaccg acgcaaagga tttaacgctc agttccaagt gaaaaaggcg     1440

attgagttga agtcaagagg agtcaagatg ctgcccagca aggatggaag ccataaaaac     1500

tctgtcttga gccaaggagg tgttgcattg gtctctgaca tgtgtccaga tcctgggatt     1560

ccagaaaatg gtagaagagc aggttccgac ttcagggttg gtgcaaatgt acagttttca     1620

tgtgaggaca attacgtgct ccagggatct aaaagcatca cctgtcagag agttacagag     1680

acgctcgctg cttggagtga ccacaggccc atctgccgag cgagaacatg tggatccaat     1740

ctgcgtgggc ccagcggcgt cattacctcc cctaattatc cggttcagta tgaagataat     1800

gcacactgtg tgtgggtcat caccaccacc gacccggaca aggtcatcaa gcttgccttt     1860

gaagagtttg agctggagcg aggctatgac accctgacgg ttggtgatgc tgggaaggtg     1920

ggagacacca gatcggtctt gtacgtgctc acgggatcca gtgttcctga cctcattgtg     1980

agcatgagca accagatgtg gctacatctg cagtcggatg atagcattgg ctcacctggg     2040

tttaaagctg tttaccaaga aattgaaaag ggagggtgtg gggatcctgg aatccccgcc     2100

tatgggaagc ggacgggcag cagtttcctc catggagata cactcacctt tgaatgcccg     2160

gcggcctttg agctggtggg ggagagagtt atcacctgtc agcagaacaa tcagtggtct     2220

ggcaacaagc ccagctgtgt attttcatgt ttcttcaact ttacggcatc atctgggatt     2280

attctgtcac caaattatcc agaggaatat gggaacaaca tgaactgtgt ctggttgatt     2340

atctcggagc caggaagtcg aattcaccta atctttaatg attttgatgt tgagcctcag     2400

tttgactttc tcgcggtcaa ggatgatggc atttctgaca taactgtcct gggtactttt     2460

tctggcaatg aagtgccttc ccagctggcc agcagtgggc atatagttcg cttggaattt     2520

cagtctgacc attccactac tggcagaggg ttcaacatca cttacaccac atttggtcag     2580

aatgagtgcc atgatcctgg cattcctata aacggacgac gttttggtga caggtttcta     2640

ctcgggagct cggtttcttt ccactgtgat gatggctttg tcaagaccca gggatccgag     2700

tccattacct gcatactgca agacgggaac gtggtctgga gctccaccgt gccccgctgt     2760

gaagctccat gtggtggaca tctgacagcg tccagcggag tcattttgcc tcctggatgg     2820

ccaggatatt ataaggattc tttacattgt gaatggataa ttgaagcaaa accaggccac     2880

tctatcaaaa taacttttga cagatttcag acagaggtca attatgacac cttggaggtc     2940

agagatgggc cagccagttc gtccccactg atcggcgagt accacggcac ccaggcaccc     3000

cagttcctca tcagcaccgg gaacttcatg tacctgctgt tcaccactga caacagccgc     3060

tccagcatcg gcttcctcat ccactatgag agtgtgacgc ttgagtcgga ttcctgcctg     3120

gacccgggca tccctgtgaa cggccatcgc cacggtggag actttggcat caggtccaca     3180

gtgactttca gctgtgaccc ggggtacaca ctaagtgacg acgagcccct cgtctgtgag     3240

aggaaccacc agtggaacca cgccttgccc agctgcgacg ctctatgtgg aggctacatc     3300

caagggaaga gtggaacagt cctttctcct gggtttccag atttttatcc aaactctcta     3360

aactgcacgt ggaccattga agtgtctcat gggaaaggag ttcaaatgat ctttcacacc     3420

tttcatcttg agagttccca cgactattta ctgatcacag aggatggaag tttttccgag     3480

cccgttgcca ggctcaccgg gtcggtgttg cctcatacga tcaaggcagg cctgtttgga     3540

aacttcactg cccagcttcg gtttatatca gacttctcaa tttcgtacga gggcttcaat     3600

atcacatttt cagaatatga cctggagcca tgtgatgatc ctggagtccc tgccttcagc     3660

cgaagaattg gttttcactt tggtgtggga gactctctga cgttttcctg cttcctggga     3720

tatcgtttag aaggtgccac caagcttacc tgcctgggtg ggggccgccg tgtgtggagt     3780

gcacctctgc caaggtgtgt ggccgaatgt ggagcaagtg tcaaaggaaa tgaaggaaca     3840

ttactgtctc caaattttcc atccaattat gataataacc atgagtgtat ctataaaata     3900

gaaacagaag ccggcaaggg catccacctt agaacacgaa gcttccagct gtttgaagga     3960

gatactctaa aggtatatga tggaaaagac agttcctcac gtccactggg cacgttcact     4020

aaaaatgaac ttctggggct gatcctaaac agcacatcca atcacctgtg gctagagttc     4080

aacaccaatg gatctgacac cgaccaaggt tttcaactca cctataccag ttttgatctg     4140

gtaaaatgtg aggatccggg catccctaac tacggctata ggatccgtga tgaaggccac     4200

tttaccgaca ctgtagttct gtacagttgc aacccggggt acgccatgca tggcagcaac     4260

accctgacct gtttgagtgg agacaggaga gtgtgggaca aaccactacc ttcgtgcata     4320

gcggaatgtg gtggtcagat ccatgcagcc acatcaggac gaatattgtc ccctggctat     4380

ccagctccgt atgacaacaa cctccactgc acctggatta tagaggcaga cccaggaaag     4440

accattagcc tccatttcat tgttttcgac acggagatgg ctcacgacat cctcaaggtc     4500

tgggacgggc cggtggacag tgacatcctg ctgaaggagt ggagtggctc cgcccttccg     4560

gaggacatcc acagcacctt caactcactc accctgcagt tcgacagcga cttcttcatc     4620

agcaagtctg gcttctccat ccagttctcc acctcaattg cagccacctg taacgatcca     4680

ggtatgcccc aaaatggcac ccgctatgga gacagcagag aggctggaga caccgtcaca     4740

ttccagtgtg accctggcta tcagctccaa ggacaagcca aaatcacctg tgtgcagctg     4800

aataaccggt tcttttggca accagaccct cctacatgca tagctgcttg tggagggaat     4860

ctgacgggcc cagcaggtgt tattttgtca cccaactacc cacagccgta tcctcctggg     4920

aaggaatgtg actggagagt aaaagtgaac ccggactttg tcatcgcctt gatattcaaa     4980

agtttcaaca tggagcccag ctatgacttc ctacacatct atgaagggga agattccaac     5040

agccccctca ttgggagtta ccagggctct caggccccag aaagaataga gagtagcgga     5100

aacagcctgt ttctggcatt tcggagtgat gcctccgtgg gcctttcagg gttcgccatt     5160

gaatttaaag agaaaccacg ggaagcttgt tttgacccag gaaatataat gaatgggaca     5220

agagttggaa cagacttcaa gcttggctcc accatcacct accagtgtga ctctggctat     5280

aagattcttg acccctcatc catcacctgt gtgattgggg ctgatgggaa accctcctgg     5340

gaccaagtgc tgccctcctg caatgctccc tgtggaggcc agtacacggg atcagaaggg     5400

gtagttttat caccaaacta cccccataat tacacagctg gtcaaatatg cctctattcc     5460

atcacggtac caaaggaatt cgtggtcttt ggacagtttg cctatttcca gacagccctg     5520

aatgatttgg cagaattatt tgatggaacc catgcacagg ccagacttct cagctcactc     5580

tcggggtctc actcagggga aacattgccc ttggctacgt caaatcaaat tctgctccga     5640

ttcagtgcaa agagcggtgc ctctgcccgc ggcttccact tcgtgtatca agctgttcct     5700

cgtaccagtg acacccaatg cagctctgtc cccgagccca gatacggaag gagaattggt     5760

tctgagtttt ctgccggctc catcgtccga ttcgagtgca acccgggata cctgcttcag     5820

ggttccacgg cgctccactg ccagtccgtg cccaacgcct tggcacagtg gaacgacacg     5880

atccccagct gtgtggtacc ctgcagtggc aatttcactc aacgaagagg tacaatcctg     5940

tcccccggct accctgagcc atacggaaac aacttgaact gtatatggaa gatcatagtt     6000

acggagggct cgggaattca gatccaagtg atcagttttg ccacggagca gaactgggac     6060

tcccttgaga tccacgatgg tggggatgtg accgcaccca gactgggaag cttctcaggc     6120

accacagtac cggcactgct gaacagtact tccaaccaac tctacctgca tttccagtct     6180

gacattagtg tggcagctgc tggtttccac ctggaataca aaactgtagg tcttgctgca     6240

tgccaagaac cagccctccc cagcaacagc atcaaaatcg gagatcggta catggtgaac     6300

gacgtgctct ccttccagtg cgagcccggg tacaccctgc agggccgttc ccacatttcc     6360

tgtatgccag ggaccgttcg ccgttggaac tatccgtctc ccctgtgcat tgcaacctgt     6420

ggagggacgc tgagcacctt gggtggtgtg atcctgagcc ccggcttccc aggttcttac     6480

cccaacaact tagactgcac ctggaggatc tcattaccca tcggctatgg tgcacatatt     6540

cagtttctga atttttctac cgaagctaat catgacttcc ttgaaattca aaatggacct     6600

taccacacca gccccatgat tggacaattt agcggcacgg atctccccgc ggccctgctg     6660

agcacaacgc atgaaaccct catccacttt tatagtgacc attcgcaaaa ccggcaagga     6720

tttaaacttg cttaccaagc ctatgaatta cagaactgtc cagatccacc cccatttcag     6780

aatgggtaca tgatcaactc ggattacagc gtggggcaat cagtatcttt cgagtgttat     6840

cctgggtaca ttctaatagg ccatcctgtc ctcacttgtc agcatgggat caacagaaac     6900

tggaactacc cttttccaag atgtgatgcc ccttgtgggt acaacgtaac ttctcagaac     6960

ggcaccatct actcccctgg ctttcctgat gagtatccga tcctgaagga ctgcatttgg     7020

ctcatcacgg tgcctccagg gcacggagtt tacatcaact tcaccctgtt acagacggaa     7080

gctgtcaacg attacattgc tgtttgggac ggtcccgatc agaactcacc ccagctggga     7140

gttttcagtg gcaacacagc cctcgaaacg gcgtatagct ccaccaacca agtcctgctc     7200

aagttccaca gcgacttttc aaatggaggc ttctttgtcc tcaatttcca cgcatttcag     7260

ctcaagaaat gtcaacctcc cccagcggtt ccacaggcag aaatgcttac tgaggatgat     7320

gatttcgaaa taggagattt tgtgaagtac cagtgccacc ccgggtacac cttggtgggg     7380

accgacattc tgacttgcaa gctcagttcc cagttgcagt ttgagggttc tctcccaaca     7440

tgtgaagcac aatgcccagc aaatgaagtc cggactggat catcgggagt cattctcagt     7500

ccagggtatc cgggtaatta ttttaactcc cagacttgct cttggagtat taaagtggaa     7560

ccaaactaca acattaccat ctttgtggac acatttcaaa gtgaaaagca gtttgatgca     7620

ctggaagtgt ttgatggttc ttctgggcaa agtcctctgc tagtagtctt aagtgggaat     7680

catactgaac aatcaaattt tacaagcagg agtaatcagt tatatctccg ctggtccact     7740

gaccatgcca ccagtaagaa aggattcaag attcgctatg cagcacctta ctgcagtttg     7800

acccaccccc tgaagaatgg gggtattcta aacaggactg caggagcggt tggaagcaaa     7860

gtgcattatt tttgcaagcc tggataccga atggtcggcc acagcaatgc aacctgtaga     7920

cgaaacccac ttggcatgta ccagtgggac tccctcacgc cactctgcca ggctgtgtcc     7980

tgtggaatcc cagaatcccc aggaaacggt tcatttaccg ggaacgagtt cactttggac     8040

agtaaagtgg tctatgaatg tcatgagggc ttcaagcttg aatccagcca gcaagcaaca     8100

gccgtgtgtc aagaagatgg gttgtggagt aacaagggga agccgcccac gtgtaagccg     8160

gtcgcttgcc ccagcattga agctcagctc tcagaacatg tcatctggag gctggtttca     8220

ggatccttga atgagtacgg tgctcaagta ttgctgagct gcagtcctgg ttactactta     8280

gaaggctgga ggctcctgcg gtgccaggcc aatgggacgt ggaacatagg agatgagagg     8340

ccaagctgtc gagttatctc gtgtggaagc ctttcctttc ccccaaatgg caacaagatt     8400

ggaacgttga cagtttatgg ggccacagct atatttacgt gcaacaccgg ctacacgctt     8460

gtggggtctc atgtcagaga gtgcttggca aatgggctct ggagcggcag cgaaactcga     8520

tgtctggctg gccactgcgg ttccccagac ccgattgtga acggtcacat tagtggagat     8580

ggcttcagtt acagagacac ggtggtttac cagtgcaatc ctggtttccg gcttgtggga     8640

acttccgtga ggatatgcct gcaagaccac aagtggtctg gacaaacgcc tgtctgtgtc     8700

cccatcacat gtggtcaccc tggaaaccct gcccacggat tcactaatgg cagtgagttc     8760

aacctgaatg atgtcgtgaa tttcacctgc aacacgggct atttgctgca gggcgtgtct     8820

cgagcccagt gtcggagcaa cggccagtgg agtagccctc tgcccacgtg tcgagtggtg     8880

aactgttctg atccaggctt tgtggaaaat gccattcgtc acgggcaaca gaacttccct     8940

gagagttttg agtatggaat gagtatcctg taccattgca agaagggatt ttacttgctg     9000

ggatcttcag ccttgacctg tatggcaaat ggcttatggg accgatccct gcccaagtgt     9060

ttggctatat cgtgtggaca cccaggggtc cctgccaacg ccgtcctcac tggagagctg     9120

tttacctatg gcgccgtcgt gcactactcc tgcagaggga gcgagagcct cataggcaac     9180

gacacgagag tgtgccagga agacagtcac tggagcgggg cactgcccca ctgcacagga     9240

aataatcctg gattctgtgg tgatccgggg accccagcac atgggtctcg gcttggtgat     9300

gactttaaga caaagagtct tctccgcttc tcctgtgaaa tggggcacca gctgaggggc     9360

tcccctgaac gcacgtgttt gctcaatggg tcatggtcag gactgcagcc ggtgtgtgag     9420

gccgtgtcct gtggcaaccc tggcacaccc accaacggaa tgattgtcag tagtgatggc     9480

attctgttct ccagctcggt catctatgcc tgctgggaag gctacaagac ctcagggctc     9540

atgacacggc attgcacagc caatgggacc tggacaggca ctgctcccga ctgcacaatt     9600

ataagttgtg gggatccagg cacactagca aatggcatcc agtttgggac cgacttcacc     9660

ttcaacaaga ctgtgagcta tcagtgtaac ccaggctatg tcatggaagc agtcacatcc     9720

gccactattc gctgtaccaa agacggcagg tggaatccga gcaaacctgt ctgcaaagcc     9780

gtgctgtgtc ctcagccgcc gccggtgcag aatggaacag tggagggaag tgatttccgc     9840

tggggctcca gcataagtta cagctgcatg gacggttacc agctctctca ctccgccatc     9900

ctctcctgtg aaggtcgcgg ggtgtggaaa ggagagatcc cccagtgtct ccctgtgttc     9960

tgcggagacc ctggcatccc cgcagaaggg cgacttagtg ggaaaagttt cacctataag    10020

tccgaagtct tcttccagtg caaatctcca tttatactcg tgggatcctc cagaagagtc    10080

tgccaagctg acggcacgtg gagcggcata caacccacct gcattgatcc tgctcataac    10140

acctgcccag accctggtac gccacacttt ggaatacaga atagctccag aggctatgag    10200

gttggaagca cggttttttt caggtgcaga aaaggctacc atattcaagg ttccacgact    10260

cgcacctgcc ttgccaattt aacatggagt gggatacaga ccgaatgtat acctcatgcc    10320

tgcagacagc cagaaacccc ggcacacgcg gatgtgagag ccatcgatct tcctactttc    10380

ggctacacct tagtgtacac ctgccatcca ggctttttcc tcgcaggggg atctgagcac    10440

agaacatgta aagcagacat gaaatggaca ggaaagtcgc ctgtgtgtaa aagtaaagga    10500

gtgagagaag ttaatgaaac agttactaaa actccagttc cttcagatgt ctttttcgtc    10560

aattcactgt ggaaggggta ttatgaatat ttagggaaaa gacaacccgc cactctaact    10620

gttgactggt tcaatgcaac aagcagtaag gtgaatgcca ccttcagcga agcctcgcca    10680

gtggagctga agttgacagg catttacaag aaggaggagg cccacttact cctgaaagct    10740

tttcaaatta aaggccaggc agatattttt gtaagcaagt tcgaaaatga caactgggga    10800

ctagatggtt atgtgtcatc tggacttgaa agaggaggat ttacttttca aggtgacatt    10860

catggaaaag actttggaaa atttaagcta gaaaggcaag atcctttaaa cccagatcaa    10920

gactcttcca gtcattacca cggcaccagc agtggctctg tggcggctgc cattctggtt    10980

cctttctttg ctctaatttt atcagggttt gcattttacc tctacaaaca cagaacgaga    11040

ccaaaagttc aatacaatgg ctatgctggg catgaaaaca gcaatggaca agcatcgttt    11100

gaaaacccca tgtatgatac aaacttaaaa cccacagaag ccaaggctgt gaggtttgac    11160

acaactctga acacagtctg tacagtggta tagccctcag tgccccaaca ggactgattc    11220

atagccatac ctctgatgga caagcagtga ttcctttggt gccatatacc actctccctt    11280

ccactctggc tttactgcag cgatcttcaa ccttgtctac tggcataagt gcagcgggga    11340

tctctactca aatgtgtcag ggtcttctac ggatcaaact acacatgcgt tttcattcca    11400

aaagtgggtt ctaaatgcct ggctgcatct gtatgaaatc aaggcacact ccaggaagac    11460

tgccacgtcg cgccaacacg tcatactcaa tgcctcagac tttcatattt ctgtgttgct    11520

gagatgcctt tcaatgcaat cgtctgggct cgtggatatg tccctcaggt gcggtgacag    11580

aatggtggca ccacgatatg tgttctcttg tgttgttttt cctttttaaa cccccatgaa    11640

cacgaatact ctgaaaaaaa taaaaagctt tctggaagaa gacacctttc tgatagaggc    11700

tcacacctac aaatgcttca ctctgtcctt ccgagacctg acaagctttg aggacctcac    11760

agctcccctg tgtgttcatc tctagggatg tttgcaattt cccagtcagc tgttctgtcg    11820

cagaatgttt aatgcacaat tttttgcact agtgtgttat gaatgactaa gattctgata    11880

aaaaaaataa attatttaca cagggtttat acacactatc cattgtatat aagcattatt    11940

tcatattatc aagctaaaca ttcccccatc agcttagttg gagtgttagg gaaaagtatt    12000

cctagatatg gcacagattt taaaaggaaa tacagtattg aagagattta ttttattatt    12060

gcttcaatta gctccattta cgtgttgaat tcattgaaga ggtccaatga gaaaaaaaca    12120

gaagcctcct tatttcacac gttttcctcc tttagtacca tcctcatcca attactgtct    12180

ctctgatact acttaatagc agggggtttg cagaaatttc tgtttgccat gtaaaactgt    12240

gaatagtaat ttattttaga tagtcgatga acttgtgggt tttagctcac aatgcagcct    12300

tcccttttgc agtgtttttt ttttgttttt tttttttttt gtcttttact gtgccatcga    12360

tctttgatat tgcattgaaa gacaatatac cacagtagca ccttgaactc agtgaaaatt    12420

gttcaggatc aaaataccaa gtgttctttt agagggaagg aaaaagtaca cacactctcc    12480

tctcacaatg atatatttta tacattcatt tgttatttgt ttcatgcttt atgattccag    12540

atggaaaggt aatttcagtg acttttcaag tttaaattcc attataggta aatgataagt    12600

tatgatgcaa ataaaatcta taagatcccc agggcaaata aaaatcaaaa catgaagtag    12660

aagatgtggc cgtgaggtag tttatgtaac aaattcaaag tgaaaatcat gtttactttt    12720

acttatactt atttgataaa aatatttttg aaacgatagt acttatttta ttatttgata    12780

tttcagttcc tattcaattg tggcagattt tctctgtttc acattttaga ttggcgttgg    12840

taatagaaat gtcagaatgt tcaaattggc cttcacgttg tcggagtgaa cacattgaca    12900

cctagcttta agactgattt atctgttggt gtactgaagg tttccatgta ggacttcaaa    12960

tgtggaaaag gaaaagcagt caggaaaatg gggcattctt tggagagtca cgcgttttga    13020

ttcggacatt tccgtagagc tcggctccca gtgttgtgtt cctcggtcga aagggtctct    13080

gctgtttggg gactcactgg cctctcctag ggactccttt gtcttgtgaa ccccacgctg    13140

ttggattctg tatcattatg ctgaattctc tgcacagttt tccctggcca acctgcccac    13200

atccttggag atttgctttg ccagtgggaa tccttacatt gctgtttcac agtagacggg    13260

acgaggtcag cgggagtcgt gctcctaaca cacacattga acgaaacaga agatgattga    13320

aagtgtgagg aggctcgtgt gcaagggaga acagggttac tatacatatt agtgtatata    13380

tatacataca tatatatata tatatattgt acatatctaa gtttgagtca ttcaaactag    13440

gtgcaaaatg ctgacttcag agtctgaatt aacatctctg ttcccatatc cctgacctgc    13500

tccctggtca acgatgctat gaaatcctga aatgacagga catacataca tacaagaaac    13560

cacatatcaa attagatatg attttccttt gtgtgcaaag tcaaactgtc ctagggttgc    13620

cagtttgaag catgttattt aaatgaaaaa aaaaatcagt gaaattctcg tgtgagaatt    13680

ctgcctagtt tcttcctaag gttgtgtgca gtgttgaacg gcgtctccgc aaggtgttgg    13740

aggatctcat tttagggcag tcaggagctg tgcttgctga gttaggtcta gaagactctt    13800

ccctgaaggc aacgggaaca cgcgtgaggg acgcgaccac acactaacag aggacacgtg    13860

cttcagagct gtttaaaact gctgcttgtt ttacacacac atcttgcctt ttttcaggct    13920

agctgcaata atttttttct tctgtaaaat attttgtaaa caacaacaaa aagctattat    13980

aaaaaggggg taaaaaaaag aacgctggca ttatgatcag gaaaacccat tgtcatcgcc    14040

gaccctccct cccgtcccac cacacgctgc tgtcacgacg taggtgcgaa agaccttttt    14100

gtacagagat atatttttta tgaagaattt gtaaaattat taaatatgct gtaatttttt    14160

gattaatgta ggtacattgt taaaaaataa atgtttttac aatacagaac tgtaattttc    14220

ccaataatgt aaaatgtacc atctctagct gattttcagt tccaatccta ttacacatgt    14280

attaatatta aagtggcctg ttaaaatgaa cagtatcttt tttttgtcaa aaaaattata    14340

aagagggtgt aatatagcct gtgcaatgcc accaatcttt aaagcaaatc agagttctaa    14400

ttaaatattt aatttta                                                   14417


<210>  283
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys 
            20                  25              


<210>  284
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  284

Gln Asn Cys Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser 
1               5                   10                  15      


Pro Gly Phe Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile 
            20                  25                  30          


Ile Ile Thr Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe 
        35                  40                  45              


Ala Leu Glu Glu Asp Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro 
    50                  55                  60                  


Gln Gln Gly Asn Leu Lys Val 
65                  70      


<210>  285
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  285

Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val Ser Thr Gly Ser Ile 
1               5                   10                  15      


Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val Ser Ala Gln Gly Phe 
            20                  25                  30          


Lys Ala Leu Tyr Glu 
        35          


<210>  286
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  286

Leu Pro Ser His Thr Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val 
1               5                   10                  15      


Leu His Gly Thr Arg Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys 
            20                  25                  30          


Leu Pro Gly Tyr Ile Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val 
        35                  40                  45              


Ser Pro Gly Asn Gly Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg 
    50                  55                  60                  


<210>  287
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  287

Glu Gly Ala Cys Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser 
1               5                   10                  15      


Ser Pro His Phe Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp 
            20                  25                  30          


Thr Ile Leu Ala Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp 
        35                  40                  45              


Phe Gln Leu Glu Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu 
    50                  55                  60                  


Ala Pro Ser Ile 
65              


<210>  288
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  288

Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn Trp 
1               5                   10                  15      


Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly Phe 
            20                  25                  30          


Asn Ala Gln Phe Gln 
        35          


<210>  289
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  289

Lys Lys Ala Ile Glu Leu Lys Ser Arg Gly Val Lys Met Leu Pro Ser 
1               5                   10                  15      


Lys Asp Gly Ser His Lys Asn Ser Val 
            20                  25  


<210>  290
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  290

Ser Gln Gly Gly Val Ala Leu Val Ser Asp Met Cys Pro Asp Pro Gly 
1               5                   10                  15      


Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe 
            20                  25              


<210>  291
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  291

Val Gly Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln 
1               5                   10                  15      


Gly Ser Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala 
            20                  25                  30          


Trp Ser Asp His Arg Pro Ile Cys Arg 
        35                  40      


<210>  292
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  292

Arg Thr Cys Gly Ser Asn Leu Arg Gly Pro Ser Gly Val Ile Thr Ser 
1               5                   10                  15      


Pro Asn Tyr Pro Val Gln Tyr Glu Asp Asn Ala His Cys Val Trp Val 
            20                  25                  30          


Ile Thr Thr Thr Asp Pro Asp Lys 
        35                  40  


<210>  293
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  293

Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr Asp 
1               5                   10                  15      


Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser Val 
            20                  25                  30          


Leu Tyr 
        


<210>  294
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  294

Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser Met Ser Asn Gln 
1               5                   10                  15      


Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly Ser Pro Gly Phe 
            20                  25                  30          


Lys Ala Val Tyr Gln 
        35          


<210>  295
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  295

Ile Glu Lys Gly Gly Cys Gly Asp Pro Gly Ile Pro Ala Tyr Gly Lys 
1               5                   10                  15      


Arg Thr Gly Ser Ser Phe Leu His Gly Asp Thr Leu Thr Phe Glu Cys 
            20                  25                  30          


Pro Ala Ala Phe Glu Leu Val Gly Glu Arg Val Ile Thr Cys Gln Gln 
        35                  40                  45              


Asn Asn Gln Trp Ser Gly Asn Lys Pro Ser Cys Val 
    50                  55                  60  


<210>  296
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  296

Ser Cys Phe Phe Asn Phe Thr Ala Ser Ser Gly Ile Ile Leu Ser Pro 
1               5                   10                  15      


Asn Tyr Pro Glu Glu Tyr Gly Asn Asn Met Asn Cys Val Trp Leu Ile 
            20                  25                  30          


Ile Ser Glu Pro Gly Ser Arg Ile His Leu Ile Phe Asn Asp Phe Asp 
        35                  40                  45              


Val Glu Pro Gln Phe Asp Phe Leu Ala Val Lys Asp Asp Gly Ile Ser 
    50                  55                  60                  


Asp Ile Thr Val Leu Gly Thr Phe Ser Gly Asn Glu Val Pro Ser Gln 
65                  70                  75                  80  


Leu Ala Ser Ser Gly His Ile Val Arg Leu Glu Phe Gln Ser Asp His 
                85                  90                  95      


Ser Thr Thr Gly Arg Gly Phe Asn Ile Thr Tyr Thr 
            100                 105             


<210>  297
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  297

Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro Ile Asn Gly Arg 
1               5                   10                  15      


Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val Ser Phe His Cys 
            20                  25                  30          


Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser Ile Thr Cys Ile 
        35                  40                  45              


Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val Pro Arg Cys Glu 
    50                  55                  60                  


<210>  298
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  298

Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly Val Ile Leu Pro Pro 
1               5                   10                  15      


Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His Cys Glu Trp Ile Ile 
            20                  25                  30          


Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe Asp 
        35                  40                  45  


<210>  299
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  299

Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp Gly Pro 
1               5                   10                  15      


Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln Ala Pro 
            20                  25                  30          


Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe Thr Thr 
        35                  40                  45              


Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu 
    50                  55                  60          


<210>  300
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  300

Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val Asn 
1               5                   10                  15      


Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr Phe 
            20                  25                  30          


Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val Cys 
        35                  40                  45              


Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp 
    50                  55                  60          


<210>  301
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  301

Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro 
1               5                   10                  15      


Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile 
            20                  25                  30          


Glu Val Ser His Gly Lys 
        35              


<210>  302
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  302

Val Gln Met Ile Phe His Thr Phe His Leu Glu Ser Ser His Asp Tyr 
1               5                   10                  15      


Leu Leu Ile Thr Glu Asp Gly Ser Phe Ser Glu Pro Val Ala Arg Leu 
            20                  25                  30          


Thr Gly Ser Val Leu Pro His Thr Ile Lys Ala Gly Leu Phe Gly Asn 
        35                  40                  45              


Phe Thr Ala Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile Ser Tyr Glu 
    50                  55                  60                  


Gly Phe Asn Ile Thr Phe Ser 
65                  70      


<210>  303
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  303

Tyr Asp Leu Glu Pro Cys Asp Asp Pro Gly Val Pro Ala Phe Ser Arg 
1               5                   10                  15      


Arg Ile Gly Phe His Phe Gly Val Gly Asp Ser Leu Thr Phe Ser Cys 
            20                  25                  30          


Phe Leu Gly Tyr Arg Leu Glu Gly Ala Thr Lys Leu Thr Cys Leu Gly 
        35                  40                  45              


Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro Arg Cys Val 
    50                  55                  60          


<210>  304
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  304

Glu Cys Gly Ala Ser Val Lys Gly Asn Glu Gly Thr Leu Leu Ser Pro 
1               5                   10                  15      


Asn Phe Pro Ser Asn Tyr Asp Asn Asn His Glu Cys Ile Tyr Lys Ile 
            20                  25                  30          


Glu Thr Glu Ala Gly Lys Gly Ile His Leu Arg Thr Arg Ser Phe Gln 
        35                  40                  45              


Leu Phe Glu Gly Asp Thr Leu Lys 
    50                  55      


<210>  305
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  305

Val Tyr Asp Gly Lys Asp Ser Ser Ser Arg Pro Leu Gly Thr Phe Thr 
1               5                   10                  15      


Lys Asn Glu Leu Leu Gly Leu Ile Leu Asn Ser Thr Ser Asn His Leu 
            20                  25                  30          


Trp Leu Glu Phe Asn Thr Asn Gly Ser Asp Thr Asp Gln Gly Phe Gln 
        35                  40                  45              


Leu Thr Tyr Thr 
    50          


<210>  306
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  306

Phe Asp Leu Val Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr Gly Tyr 
1               5                   10                  15      


Arg Ile Arg Asp Glu Gly His Phe Thr Asp Thr Val Val Leu Tyr Ser 
            20                  25                  30          


Cys Asn Pro Gly Tyr Ala Met His Gly Ser Asn Thr Leu Thr Cys Leu 
        35                  40                  45              


Ser Gly Asp Arg Arg Val Trp Asp Lys Pro Leu Pro Ser Cys Ile 
    50                  55                  60              


<210>  307
<211>  2353
<212>  PRT
<213>  Homo sapiens

<400>  307

Phe Asp Leu Val Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr Gly Tyr 
1               5                   10                  15      


Arg Ile Arg Asp Glu Gly His Phe Thr Asp Thr Val Val Leu Tyr Ser 
            20                  25                  30          


Cys Asn Pro Gly Tyr Ala Met His Gly Ser Asn Thr Leu Thr Cys Leu 
        35                  40                  45              


Ser Gly Asp Arg Arg Val Trp Asp Lys Pro Leu Pro Ser Cys Ile Ala 
    50                  55                  60                  


Glu Cys Gly Gly Gln Ile His Ala Ala Thr Ser Gly Arg Ile Leu Ser 
65                  70                  75                  80  


Pro Gly Tyr Pro Ala Pro Tyr Asp Asn Asn Leu His Cys Thr Trp Ile 
                85                  90                  95      


Ile Glu Ala Asp Pro Gly Lys Thr Ile Ser Leu His Phe Ile Val Phe 
            100                 105                 110         


Asp Thr Glu Met Ala His Asp Ile Leu Lys Val Trp Asp Gly Pro Val 
        115                 120                 125             


Asp Ser Asp Ile Leu Leu Lys Glu Trp Ser Gly Ser Ala Leu Pro Glu 
    130                 135                 140                 


Asp Ile His Ser Thr Phe Asn Ser Leu Thr Leu Gln Phe Asp Ser Asp 
145                 150                 155                 160 


Phe Phe Ile Ser Lys Ser Gly Phe Ser Ile Gln Phe Ser Thr Ser Ile 
                165                 170                 175     


Ala Ala Thr Cys Asn Asp Pro Gly Met Pro Gln Asn Gly Thr Arg Tyr 
            180                 185                 190         


Gly Asp Ser Arg Glu Ala Gly Asp Thr Val Thr Phe Gln Cys Asp Pro 
        195                 200                 205             


Gly Tyr Gln Leu Gln Gly Gln Ala Lys Ile Thr Cys Val Gln Leu Asn 
    210                 215                 220                 


Asn Arg Phe Phe Trp Gln Pro Asp Pro Pro Thr Cys Ile Ala Ala Cys 
225                 230                 235                 240 


Gly Gly Asn Leu Thr Gly Pro Ala Gly Val Ile Leu Ser Pro Asn Tyr 
                245                 250                 255     


Pro Gln Pro Tyr Pro Pro Gly Lys Glu Cys Asp Trp Arg Val Lys Val 
            260                 265                 270         


Asn Pro Asp Phe Val Ile Ala Leu Ile Phe Lys Ser Phe Asn Met Glu 
        275                 280                 285             


Pro Ser Tyr Asp Phe Leu His Ile Tyr Glu Gly Glu Asp Ser Asn Ser 
    290                 295                 300                 


Pro Leu Ile Gly Ser Tyr Gln Gly Ser Gln Ala Pro Glu Arg Ile Glu 
305                 310                 315                 320 


Ser Ser Gly Asn Ser Leu Phe Leu Ala Phe Arg Ser Asp Ala Ser Val 
                325                 330                 335     


Gly Leu Ser Gly Phe Ala Ile Glu Phe Lys Glu Lys Pro Arg Glu Ala 
            340                 345                 350         


Cys Phe Asp Pro Gly Asn Ile Met Asn Gly Thr Arg Val Gly Thr Asp 
        355                 360                 365             


Phe Lys Leu Gly Ser Thr Ile Thr Tyr Gln Cys Asp Ser Gly Tyr Lys 
    370                 375                 380                 


Ile Leu Asp Pro Ser Ser Ile Thr Cys Val Ile Gly Ala Asp Gly Lys 
385                 390                 395                 400 


Pro Ser Trp Asp Gln Val Leu Pro Ser Cys Asn Ala Pro Cys Gly Gly 
                405                 410                 415     


Gln Tyr Thr Gly Ser Glu Gly Val Val Leu Ser Pro Asn Tyr Pro His 
            420                 425                 430         


Asn Tyr Thr Ala Gly Gln Ile Cys Leu Tyr Ser Ile Thr Val Pro Lys 
        435                 440                 445             


Glu Phe Val Val Phe Gly Gln Phe Ala Tyr Phe Gln Thr Ala Leu Asn 
    450                 455                 460                 


Asp Leu Ala Glu Leu Phe Asp Gly Thr His Ala Gln Ala Arg Leu Leu 
465                 470                 475                 480 


Ser Ser Leu Ser Gly Ser His Ser Gly Glu Thr Leu Pro Leu Ala Thr 
                485                 490                 495     


Ser Asn Gln Ile Leu Leu Arg Phe Ser Ala Lys Ser Gly Ala Ser Ala 
            500                 505                 510         


Arg Gly Phe His Phe Val Tyr Gln Ala Val Pro Arg Thr Ser Asp Thr 
        515                 520                 525             


Gln Cys Ser Ser Val Pro Glu Pro Arg Tyr Gly Arg Arg Ile Gly Ser 
    530                 535                 540                 


Glu Phe Ser Ala Gly Ser Ile Val Arg Phe Glu Cys Asn Pro Gly Tyr 
545                 550                 555                 560 


Leu Leu Gln Gly Ser Thr Ala Leu His Cys Gln Ser Val Pro Asn Ala 
                565                 570                 575     


Leu Ala Gln Trp Asn Asp Thr Ile Pro Ser Cys Val Val Pro Cys Ser 
            580                 585                 590         


Gly Asn Phe Thr Gln Arg Arg Gly Thr Ile Leu Ser Pro Gly Tyr Pro 
        595                 600                 605             


Glu Pro Tyr Gly Asn Asn Leu Asn Cys Ile Trp Lys Ile Ile Val Thr 
    610                 615                 620                 


Glu Gly Ser Gly Ile Gln Ile Gln Val Ile Ser Phe Ala Thr Glu Gln 
625                 630                 635                 640 


Asn Trp Asp Ser Leu Glu Ile His Asp Gly Gly Asp Val Thr Ala Pro 
                645                 650                 655     


Arg Leu Gly Ser Phe Ser Gly Thr Thr Val Pro Ala Leu Leu Asn Ser 
            660                 665                 670         


Thr Ser Asn Gln Leu Tyr Leu His Phe Gln Ser Asp Ile Ser Val Ala 
        675                 680                 685             


Ala Ala Gly Phe His Leu Glu Tyr Lys Thr Val Gly Leu Ala Ala Cys 
    690                 695                 700                 


Gln Glu Pro Ala Leu Pro Ser Asn Ser Ile Lys Ile Gly Asp Arg Tyr 
705                 710                 715                 720 


Met Val Asn Asp Val Leu Ser Phe Gln Cys Glu Pro Gly Tyr Thr Leu 
                725                 730                 735     


Gln Gly Arg Ser His Ile Ser Cys Met Pro Gly Thr Val Arg Arg Trp 
            740                 745                 750         


Asn Tyr Pro Ser Pro Leu Cys Ile Ala Thr Cys Gly Gly Thr Leu Ser 
        755                 760                 765             


Thr Leu Gly Gly Val Ile Leu Ser Pro Gly Phe Pro Gly Ser Tyr Pro 
    770                 775                 780                 


Asn Asn Leu Asp Cys Thr Trp Arg Ile Ser Leu Pro Ile Gly Tyr Gly 
785                 790                 795                 800 


Ala His Ile Gln Phe Leu Asn Phe Ser Thr Glu Ala Asn His Asp Phe 
                805                 810                 815     


Leu Glu Ile Gln Asn Gly Pro Tyr His Thr Ser Pro Met Ile Gly Gln 
            820                 825                 830         


Phe Ser Gly Thr Asp Leu Pro Ala Ala Leu Leu Ser Thr Thr His Glu 
        835                 840                 845             


Thr Leu Ile His Phe Tyr Ser Asp His Ser Gln Asn Arg Gln Gly Phe 
    850                 855                 860                 


Lys Leu Ala Tyr Gln Ala Tyr Glu Leu Gln Asn Cys Pro Asp Pro Pro 
865                 870                 875                 880 


Pro Phe Gln Asn Gly Tyr Met Ile Asn Ser Asp Tyr Ser Val Gly Gln 
                885                 890                 895     


Ser Val Ser Phe Glu Cys Tyr Pro Gly Tyr Ile Leu Ile Gly His Pro 
            900                 905                 910         


Val Leu Thr Cys Gln His Gly Ile Asn Arg Asn Trp Asn Tyr Pro Phe 
        915                 920                 925             


Pro Arg Cys Asp Ala Pro Cys Gly Tyr Asn Val Thr Ser Gln Asn Gly 
    930                 935                 940                 


Thr Ile Tyr Ser Pro Gly Phe Pro Asp Glu Tyr Pro Ile Leu Lys Asp 
945                 950                 955                 960 


Cys Ile Trp Leu Ile Thr Val Pro Pro Gly His Gly Val Tyr Ile Asn 
                965                 970                 975     


Phe Thr Leu Leu Gln Thr Glu Ala Val Asn Asp Tyr Ile Ala Val Trp 
            980                 985                 990         


Asp Gly Pro Asp Gln Asn Ser Pro  Gln Leu Gly Val Phe  Ser Gly Asn 
        995                 1000                 1005             


Thr Ala  Leu Glu Thr Ala Tyr  Ser Ser Thr Asn Gln  Val Leu Leu 
    1010                 1015                 1020             


Lys Phe  His Ser Asp Phe Ser  Asn Gly Gly Phe Phe  Val Leu Asn 
    1025                 1030                 1035             


Phe His  Ala Phe Gln Leu Lys  Lys Cys Gln Pro Pro  Pro Ala Val 
    1040                 1045                 1050             


Pro Gln  Ala Glu Met Leu Thr  Glu Asp Asp Asp Phe  Glu Ile Gly 
    1055                 1060                 1065             


Asp Phe  Val Lys Tyr Gln Cys  His Pro Gly Tyr Thr  Leu Val Gly 
    1070                 1075                 1080             


Thr Asp  Ile Leu Thr Cys Lys  Leu Ser Ser Gln Leu  Gln Phe Glu 
    1085                 1090                 1095             


Gly Ser  Leu Pro Thr Cys Glu  Ala Gln Cys Pro Ala  Asn Glu Val 
    1100                 1105                 1110             


Arg Thr  Gly Ser Ser Gly Val  Ile Leu Ser Pro Gly  Tyr Pro Gly 
    1115                 1120                 1125             


Asn Tyr  Phe Asn Ser Gln Thr  Cys Ser Trp Ser Ile  Lys Val Glu 
    1130                 1135                 1140             


Pro Asn  Tyr Asn Ile Thr Ile  Phe Val Asp Thr Phe  Gln Ser Glu 
    1145                 1150                 1155             


Lys Gln  Phe Asp Ala Leu Glu  Val Phe Asp Gly Ser  Ser Gly Gln 
    1160                 1165                 1170             


Ser Pro  Leu Leu Val Val Leu  Ser Gly Asn His Thr  Glu Gln Ser 
    1175                 1180                 1185             


Asn Phe  Thr Ser Arg Ser Asn  Gln Leu Tyr Leu Arg  Trp Ser Thr 
    1190                 1195                 1200             


Asp His  Ala Thr Ser Lys Lys  Gly Phe Lys Ile Arg  Tyr Ala Ala 
    1205                 1210                 1215             


Pro Tyr  Cys Ser Leu Thr His  Pro Leu Lys Asn Gly  Gly Ile Leu 
    1220                 1225                 1230             


Asn Arg  Thr Ala Gly Ala Val  Gly Ser Lys Val His  Tyr Phe Cys 
    1235                 1240                 1245             


Lys Pro  Gly Tyr Arg Met Val  Gly His Ser Asn Ala  Thr Cys Arg 
    1250                 1255                 1260             


Arg Asn  Pro Leu Gly Met Tyr  Gln Trp Asp Ser Leu  Thr Pro Leu 
    1265                 1270                 1275             


Cys Gln  Ala Val Ser Cys Gly  Ile Pro Glu Ser Pro  Gly Asn Gly 
    1280                 1285                 1290             


Ser Phe  Thr Gly Asn Glu Phe  Thr Leu Asp Ser Lys  Val Val Tyr 
    1295                 1300                 1305             


Glu Cys  His Glu Gly Phe Lys  Leu Glu Ser Ser Gln  Gln Ala Thr 
    1310                 1315                 1320             


Ala Val  Cys Gln Glu Asp Gly  Leu Trp Ser Asn Lys  Gly Lys Pro 
    1325                 1330                 1335             


Pro Thr  Cys Lys Pro Val Ala  Cys Pro Ser Ile Glu  Ala Gln Leu 
    1340                 1345                 1350             


Ser Glu  His Val Ile Trp Arg  Leu Val Ser Gly Ser  Leu Asn Glu 
    1355                 1360                 1365             


Tyr Gly  Ala Gln Val Leu Leu  Ser Cys Ser Pro Gly  Tyr Tyr Leu 
    1370                 1375                 1380             


Glu Gly  Trp Arg Leu Leu Arg  Cys Gln Ala Asn Gly  Thr Trp Asn 
    1385                 1390                 1395             


Ile Gly  Asp Glu Arg Pro Ser  Cys Arg Val Ile Ser  Cys Gly Ser 
    1400                 1405                 1410             


Leu Ser  Phe Pro Pro Asn Gly  Asn Lys Ile Gly Thr  Leu Thr Val 
    1415                 1420                 1425             


Tyr Gly  Ala Thr Ala Ile Phe  Thr Cys Asn Thr Gly  Tyr Thr Leu 
    1430                 1435                 1440             


Val Gly  Ser His Val Arg Glu  Cys Leu Ala Asn Gly  Leu Trp Ser 
    1445                 1450                 1455             


Gly Ser  Glu Thr Arg Cys Leu  Ala Gly His Cys Gly  Ser Pro Asp 
    1460                 1465                 1470             


Pro Ile  Val Asn Gly His Ile  Ser Gly Asp Gly Phe  Ser Tyr Arg 
    1475                 1480                 1485             


Asp Thr  Val Val Tyr Gln Cys  Asn Pro Gly Phe Arg  Leu Val Gly 
    1490                 1495                 1500             


Thr Ser  Val Arg Ile Cys Leu  Gln Asp His Lys Trp  Ser Gly Gln 
    1505                 1510                 1515             


Thr Pro  Val Cys Val Pro Ile  Thr Cys Gly His Pro  Gly Asn Pro 
    1520                 1525                 1530             


Ala His  Gly Phe Thr Asn Gly  Ser Glu Phe Asn Leu  Asn Asp Val 
    1535                 1540                 1545             


Val Asn  Phe Thr Cys Asn Thr  Gly Tyr Leu Leu Gln  Gly Val Ser 
    1550                 1555                 1560             


Arg Ala  Gln Cys Arg Ser Asn  Gly Gln Trp Ser Ser  Pro Leu Pro 
    1565                 1570                 1575             


Thr Cys  Arg Val Val Asn Cys  Ser Asp Pro Gly Phe  Val Glu Asn 
    1580                 1585                 1590             


Ala Ile  Arg His Gly Gln Gln  Asn Phe Pro Glu Ser  Phe Glu Tyr 
    1595                 1600                 1605             


Gly Met  Ser Ile Leu Tyr His  Cys Lys Lys Gly Phe  Tyr Leu Leu 
    1610                 1615                 1620             


Gly Ser  Ser Ala Leu Thr Cys  Met Ala Asn Gly Leu  Trp Asp Arg 
    1625                 1630                 1635             


Ser Leu  Pro Lys Cys Leu Ala  Ile Ser Cys Gly His  Pro Gly Val 
    1640                 1645                 1650             


Pro Ala  Asn Ala Val Leu Thr  Gly Glu Leu Phe Thr  Tyr Gly Ala 
    1655                 1660                 1665             


Val Val  His Tyr Ser Cys Arg  Gly Ser Glu Ser Leu  Ile Gly Asn 
    1670                 1675                 1680             


Asp Thr  Arg Val Cys Gln Glu  Asp Ser His Trp Ser  Gly Ala Leu 
    1685                 1690                 1695             


Pro His  Cys Thr Gly Asn Asn  Pro Gly Phe Cys Gly  Asp Pro Gly 
    1700                 1705                 1710             


Thr Pro  Ala His Gly Ser Arg  Leu Gly Asp Asp Phe  Lys Thr Lys 
    1715                 1720                 1725             


Ser Leu  Leu Arg Phe Ser Cys  Glu Met Gly His Gln  Leu Arg Gly 
    1730                 1735                 1740             


Ser Pro  Glu Arg Thr Cys Leu  Leu Asn Gly Ser Trp  Ser Gly Leu 
    1745                 1750                 1755             


Gln Pro  Val Cys Glu Ala Val  Ser Cys Gly Asn Pro  Gly Thr Pro 
    1760                 1765                 1770             


Thr Asn  Gly Met Ile Val Ser  Ser Asp Gly Ile Leu  Phe Ser Ser 
    1775                 1780                 1785             


Ser Val  Ile Tyr Ala Cys Trp  Glu Gly Tyr Lys Thr  Ser Gly Leu 
    1790                 1795                 1800             


Met Thr  Arg His Cys Thr Ala  Asn Gly Thr Trp Thr  Gly Thr Ala 
    1805                 1810                 1815             


Pro Asp  Cys Thr Ile Ile Ser  Cys Gly Asp Pro Gly  Thr Leu Ala 
    1820                 1825                 1830             


Asn Gly  Ile Gln Phe Gly Thr  Asp Phe Thr Phe Asn  Lys Thr Val 
    1835                 1840                 1845             


Ser Tyr  Gln Cys Asn Pro Gly  Tyr Val Met Glu Ala  Val Thr Ser 
    1850                 1855                 1860             


Ala Thr  Ile Arg Cys Thr Lys  Asp Gly Arg Trp Asn  Pro Ser Lys 
    1865                 1870                 1875             


Pro Val  Cys Lys Ala Val Leu  Cys Pro Gln Pro Pro  Pro Val Gln 
    1880                 1885                 1890             


Asn Gly  Thr Val Glu Gly Ser  Asp Phe Arg Trp Gly  Ser Ser Ile 
    1895                 1900                 1905             


Ser Tyr  Ser Cys Met Asp Gly  Tyr Gln Leu Ser His  Ser Ala Ile 
    1910                 1915                 1920             


Leu Ser  Cys Glu Gly Arg Gly  Val Trp Lys Gly Glu  Ile Pro Gln 
    1925                 1930                 1935             


Cys Leu  Pro Val Phe Cys Gly  Asp Pro Gly Ile Pro  Ala Glu Gly 
    1940                 1945                 1950             


Arg Leu  Ser Gly Lys Ser Phe  Thr Tyr Lys Ser Glu  Val Phe Phe 
    1955                 1960                 1965             


Gln Cys  Lys Ser Pro Phe Ile  Leu Val Gly Ser Ser  Arg Arg Val 
    1970                 1975                 1980             


Cys Gln  Ala Asp Gly Thr Trp  Ser Gly Ile Gln Pro  Thr Cys Ile 
    1985                 1990                 1995             


Asp Pro  Ala His Asn Thr Cys  Pro Asp Pro Gly Thr  Pro His Phe 
    2000                 2005                 2010             


Gly Ile  Gln Asn Ser Ser Arg  Gly Tyr Glu Val Gly  Ser Thr Val 
    2015                 2020                 2025             


Phe Phe  Arg Cys Arg Lys Gly  Tyr His Ile Gln Gly  Ser Thr Thr 
    2030                 2035                 2040             


Arg Thr  Cys Leu Ala Asn Leu  Thr Trp Ser Gly Ile  Gln Thr Glu 
    2045                 2050                 2055             


Cys Ile  Pro His Ala Cys Arg  Gln Pro Glu Thr Pro  Ala His Ala 
    2060                 2065                 2070             


Asp Val  Arg Ala Ile Asp Leu  Pro Thr Phe Gly Tyr  Thr Leu Val 
    2075                 2080                 2085             


Tyr Thr  Cys His Pro Gly Phe  Phe Leu Ala Gly Gly  Ser Glu His 
    2090                 2095                 2100             


Arg Thr  Cys Lys Ala Asp Met  Lys Trp Thr Gly Lys  Ser Pro Val 
    2105                 2110                 2115             


Cys Lys  Ser Lys Gly Val Arg  Glu Val Asn Glu Thr  Val Thr Lys 
    2120                 2125                 2130             


Thr Pro  Val Pro Ser Asp Val  Phe Phe Val Asn Ser  Leu Trp Lys 
    2135                 2140                 2145             


Gly Tyr  Tyr Glu Tyr Leu Gly  Lys Arg Gln Pro Ala  Thr Leu Thr 
    2150                 2155                 2160             


Val Asp  Trp Phe Asn Ala Thr  Ser Ser Lys Val Asn  Ala Thr Phe 
    2165                 2170                 2175             


Ser Glu  Ala Ser Pro Val Glu  Leu Lys Leu Thr Gly  Ile Tyr Lys 
    2180                 2185                 2190             


Lys Glu  Glu Ala His Leu Leu  Leu Lys Ala Phe Gln  Ile Lys Gly 
    2195                 2200                 2205             


Gln Ala  Asp Ile Phe Val Ser  Lys Phe Glu Asn Asp  Asn Trp Gly 
    2210                 2215                 2220             


Leu Asp  Gly Tyr Val Ser Ser  Gly Leu Glu Arg Gly  Gly Phe Thr 
    2225                 2230                 2235             


Phe Gln  Gly Asp Ile His Gly  Lys Asp Phe Gly Lys  Phe Lys Leu 
    2240                 2245                 2250             


Glu Arg  Gln Asp Pro Leu Asn  Pro Asp Gln Asp Ser  Ser Ser His 
    2255                 2260                 2265             


Tyr His  Gly Thr Ser Ser Gly  Ser Val Ala Ala Ala  Ile Leu Val 
    2270                 2275                 2280             


Pro Phe  Phe Ala Leu Ile Leu  Ser Gly Phe Ala Phe  Tyr Leu Tyr 
    2285                 2290                 2295             


Lys His  Arg Thr Arg Pro Lys  Val Gln Tyr Asn Gly  Tyr Ala Gly 
    2300                 2305                 2310             


His Glu  Asn Ser Asn Gly Gln  Ala Ser Phe Glu Asn  Pro Met Tyr 
    2315                 2320                 2325             


Asp Thr  Asn Leu Lys Pro Thr  Glu Ala Lys Ala Val  Arg Phe Asp 
    2330                 2335                 2340             


Thr Thr  Leu Asn Thr Val Cys  Thr Val Val 
    2345                 2350             


<210>  308
<211>  3564
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys 
            20                  25                  30          


Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe 
        35                  40                  45              


Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr 
    50                  55                  60                  


Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu 
65                  70                  75                  80  


Glu Asp Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly 
                85                  90                  95      


Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val 
            100                 105                 110         


Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val 
        115                 120                 125             


Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr 
    130                 135                 140                 


Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg 
145                 150                 155                 160 


Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile 
                165                 170                 175     


Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly 
            180                 185                 190         


Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys 
        195                 200                 205             


Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe 
    210                 215                 220                 


Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala 
225                 230                 235                 240 


Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu 
                245                 250                 255     


Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile 
            260                 265                 270         


Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn 
        275                 280                 285             


Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly 
    290                 295                 300                 


Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg 
305                 310                 315                 320 


Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val 
                325                 330                 335     


Leu Ser Gln Gly Gly Val Ala Leu Val Ser Asp Met Cys Pro Asp Pro 
            340                 345                 350         


Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Arg Val Gly 
        355                 360                 365             


Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly Ser 
    370                 375                 380                 


Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp Ser 
385                 390                 395                 400 


Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu Arg 
                405                 410                 415     


Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr Glu 
            420                 425                 430         


Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp Lys 
        435                 440                 445             


Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr Asp 
    450                 455                 460                 


Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser Val 
465                 470                 475                 480 


Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser Met 
                485                 490                 495     


Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly Ser 
            500                 505                 510         


Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys Gly 
        515                 520                 525             


Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe Leu 
    530                 535                 540                 


His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu Val 
545                 550                 555                 560 


Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly Asn 
                565                 570                 575     


Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser Ser 
            580                 585                 590         


Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn Met 
        595                 600                 605             


Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His Leu 
    610                 615                 620                 


Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala Val 
625                 630                 635                 640 


Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser Gly 
                645                 650                 655     


Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg Leu 
            660                 665                 670         


Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile Thr 
        675                 680                 685             


Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro Ile 
    690                 695                 700                 


Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val Ser 
705                 710                 715                 720 


Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser Ile 
                725                 730                 735     


Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val Pro 
            740                 745                 750         


Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly Val 
        755                 760                 765             


Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His Cys 
    770                 775                 780                 


Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe 
785                 790                 795                 800 


Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp 
                805                 810                 815     


Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln 
            820                 825                 830         


Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe 
        835                 840                 845             


Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu 
    850                 855                 860                 


Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val 
865                 870                 875                 880 


Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr 
                885                 890                 895     


Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val 
            900                 905                 910         


Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp Ala 
        915                 920                 925             


Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro 
    930                 935                 940                 


Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile 
945                 950                 955                 960 


Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe His 
                965                 970                 975     


Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe 
            980                 985                 990         


Ser Glu Pro Val Ala Arg Leu Thr  Gly Ser Val Leu Pro  His Thr Ile 
        995                 1000                 1005             


Lys Ala  Gly Leu Phe Gly Asn  Phe Thr Ala Gln Leu  Arg Phe Ile 
    1010                 1015                 1020             


Ser Asp  Phe Ser Ile Ser Tyr  Glu Gly Phe Asn Ile  Thr Phe Ser 
    1025                 1030                 1035             


Glu Tyr  Asp Leu Glu Pro Cys  Asp Asp Pro Gly Val  Pro Ala Phe 
    1040                 1045                 1050             


Ser Arg  Arg Ile Gly Phe His  Phe Gly Val Gly Asp  Ser Leu Thr 
    1055                 1060                 1065             


Phe Ser  Cys Phe Leu Gly Tyr  Arg Leu Glu Gly Ala  Thr Lys Leu 
    1070                 1075                 1080             


Thr Cys  Leu Gly Gly Gly Arg  Arg Val Trp Ser Ala  Pro Leu Pro 
    1085                 1090                 1095             


Arg Cys  Val Ala Glu Cys Gly  Ala Ser Val Lys Gly  Asn Glu Gly 
    1100                 1105                 1110             


Thr Leu  Leu Ser Pro Asn Phe  Pro Ser Asn Tyr Asp  Asn Asn His 
    1115                 1120                 1125             


Glu Cys  Ile Tyr Lys Ile Glu  Thr Glu Ala Gly Lys  Gly Ile His 
    1130                 1135                 1140             


Leu Arg  Thr Arg Ser Phe Gln  Leu Phe Glu Gly Asp  Thr Leu Lys 
    1145                 1150                 1155             


Val Tyr  Asp Gly Lys Asp Ser  Ser Ser Arg Pro Leu  Gly Thr Phe 
    1160                 1165                 1170             


Thr Lys  Asn Glu Leu Leu Gly  Leu Ile Leu Asn Ser  Thr Ser Asn 
    1175                 1180                 1185             


His Leu  Trp Leu Glu Phe Asn  Thr Asn Gly Ser Asp  Thr Asp Gln 
    1190                 1195                 1200             


Gly Phe  Gln Leu Thr Tyr Thr  Ser Phe Asp Leu Val  Lys Cys Glu 
    1205                 1210                 1215             


Asp Pro  Gly Ile Pro Asn Tyr  Gly Tyr Arg Ile Arg  Asp Glu Gly 
    1220                 1225                 1230             


His Phe  Thr Asp Thr Val Val  Leu Tyr Ser Cys Asn  Pro Gly Tyr 
    1235                 1240                 1245             


Ala Met  His Gly Ser Asn Thr  Leu Thr Cys Leu Ser  Gly Asp Arg 
    1250                 1255                 1260             


Arg Val  Trp Asp Lys Pro Leu  Pro Ser Cys Ile Ala  Glu Cys Gly 
    1265                 1270                 1275             


Gly Gln  Ile His Ala Ala Thr  Ser Gly Arg Ile Leu  Ser Pro Gly 
    1280                 1285                 1290             


Tyr Pro  Ala Pro Tyr Asp Asn  Asn Leu His Cys Thr  Trp Ile Ile 
    1295                 1300                 1305             


Glu Ala  Asp Pro Gly Lys Thr  Ile Ser Leu His Phe  Ile Val Phe 
    1310                 1315                 1320             


Asp Thr  Glu Met Ala His Asp  Ile Leu Lys Val Trp  Asp Gly Pro 
    1325                 1330                 1335             


Val Asp  Ser Asp Ile Leu Leu  Lys Glu Trp Ser Gly  Ser Ala Leu 
    1340                 1345                 1350             


Pro Glu  Asp Ile His Ser Thr  Phe Asn Ser Leu Thr  Leu Gln Phe 
    1355                 1360                 1365             


Asp Ser  Asp Phe Phe Ile Ser  Lys Ser Gly Phe Ser  Ile Gln Phe 
    1370                 1375                 1380             


Ser Thr  Ser Ile Ala Ala Thr  Cys Asn Asp Pro Gly  Met Pro Gln 
    1385                 1390                 1395             


Asn Gly  Thr Arg Tyr Gly Asp  Ser Arg Glu Ala Gly  Asp Thr Val 
    1400                 1405                 1410             


Thr Phe  Gln Cys Asp Pro Gly  Tyr Gln Leu Gln Gly  Gln Ala Lys 
    1415                 1420                 1425             


Ile Thr  Cys Val Gln Leu Asn  Asn Arg Phe Phe Trp  Gln Pro Asp 
    1430                 1435                 1440             


Pro Pro  Thr Cys Ile Ala Ala  Cys Gly Gly Asn Leu  Thr Gly Pro 
    1445                 1450                 1455             


Ala Gly  Val Ile Leu Ser Pro  Asn Tyr Pro Gln Pro  Tyr Pro Pro 
    1460                 1465                 1470             


Gly Lys  Glu Cys Asp Trp Arg  Val Lys Val Asn Pro  Asp Phe Val 
    1475                 1480                 1485             


Ile Ala  Leu Ile Phe Lys Ser  Phe Asn Met Glu Pro  Ser Tyr Asp 
    1490                 1495                 1500             


Phe Leu  His Ile Tyr Glu Gly  Glu Asp Ser Asn Ser  Pro Leu Ile 
    1505                 1510                 1515             


Gly Ser  Tyr Gln Gly Ser Gln  Ala Pro Glu Arg Ile  Glu Ser Ser 
    1520                 1525                 1530             


Gly Asn  Ser Leu Phe Leu Ala  Phe Arg Ser Asp Ala  Ser Val Gly 
    1535                 1540                 1545             


Leu Ser  Gly Phe Ala Ile Glu  Phe Lys Glu Lys Pro  Arg Glu Ala 
    1550                 1555                 1560             


Cys Phe  Asp Pro Gly Asn Ile  Met Asn Gly Thr Arg  Val Gly Thr 
    1565                 1570                 1575             


Asp Phe  Lys Leu Gly Ser Thr  Ile Thr Tyr Gln Cys  Asp Ser Gly 
    1580                 1585                 1590             


Tyr Lys  Ile Leu Asp Pro Ser  Ser Ile Thr Cys Val  Ile Gly Ala 
    1595                 1600                 1605             


Asp Gly  Lys Pro Ser Trp Asp  Gln Val Leu Pro Ser  Cys Asn Ala 
    1610                 1615                 1620             


Pro Cys  Gly Gly Gln Tyr Thr  Gly Ser Glu Gly Val  Val Leu Ser 
    1625                 1630                 1635             


Pro Asn  Tyr Pro His Asn Tyr  Thr Ala Gly Gln Ile  Cys Leu Tyr 
    1640                 1645                 1650             


Ser Ile  Thr Val Pro Lys Glu  Phe Val Val Phe Gly  Gln Phe Ala 
    1655                 1660                 1665             


Tyr Phe  Gln Thr Ala Leu Asn  Asp Leu Ala Glu Leu  Phe Asp Gly 
    1670                 1675                 1680             


Thr His  Ala Gln Ala Arg Leu  Leu Ser Ser Leu Ser  Gly Ser His 
    1685                 1690                 1695             


Ser Gly  Glu Thr Leu Pro Leu  Ala Thr Ser Asn Gln  Ile Leu Leu 
    1700                 1705                 1710             


Arg Phe  Ser Ala Lys Ser Gly  Ala Ser Ala Arg Gly  Phe His Phe 
    1715                 1720                 1725             


Val Tyr  Gln Ala Val Pro Arg  Thr Ser Asp Thr Gln  Cys Ser Ser 
    1730                 1735                 1740             


Val Pro  Glu Pro Arg Tyr Gly  Arg Arg Ile Gly Ser  Glu Phe Ser 
    1745                 1750                 1755             


Ala Gly  Ser Ile Val Arg Phe  Glu Cys Asn Pro Gly  Tyr Leu Leu 
    1760                 1765                 1770             


Gln Gly  Ser Thr Ala Leu His  Cys Gln Ser Val Pro  Asn Ala Leu 
    1775                 1780                 1785             


Ala Gln  Trp Asn Asp Thr Ile  Pro Ser Cys Val Val  Pro Cys Ser 
    1790                 1795                 1800             


Gly Asn  Phe Thr Gln Arg Arg  Gly Thr Ile Leu Ser  Pro Gly Tyr 
    1805                 1810                 1815             


Pro Glu  Pro Tyr Gly Asn Asn  Leu Asn Cys Ile Trp  Lys Ile Ile 
    1820                 1825                 1830             


Val Thr  Glu Gly Ser Gly Ile  Gln Ile Gln Val Ile  Ser Phe Ala 
    1835                 1840                 1845             


Thr Glu  Gln Asn Trp Asp Ser  Leu Glu Ile His Asp  Gly Gly Asp 
    1850                 1855                 1860             


Val Thr  Ala Pro Arg Leu Gly  Ser Phe Ser Gly Thr  Thr Val Pro 
    1865                 1870                 1875             


Ala Leu  Leu Asn Ser Thr Ser  Asn Gln Leu Tyr Leu  His Phe Gln 
    1880                 1885                 1890             


Ser Asp  Ile Ser Val Ala Ala  Ala Gly Phe His Leu  Glu Tyr Lys 
    1895                 1900                 1905             


Thr Val  Gly Leu Ala Ala Cys  Gln Glu Pro Ala Leu  Pro Ser Asn 
    1910                 1915                 1920             


Ser Ile  Lys Ile Gly Asp Arg  Tyr Met Val Asn Asp  Val Leu Ser 
    1925                 1930                 1935             


Phe Gln  Cys Glu Pro Gly Tyr  Thr Leu Gln Gly Arg  Ser His Ile 
    1940                 1945                 1950             


Ser Cys  Met Pro Gly Thr Val  Arg Arg Trp Asn Tyr  Pro Ser Pro 
    1955                 1960                 1965             


Leu Cys  Ile Ala Thr Cys Gly  Gly Thr Leu Ser Thr  Leu Gly Gly 
    1970                 1975                 1980             


Val Ile  Leu Ser Pro Gly Phe  Pro Gly Ser Tyr Pro  Asn Asn Leu 
    1985                 1990                 1995             


Asp Cys  Thr Trp Arg Ile Ser  Leu Pro Ile Gly Tyr  Gly Ala His 
    2000                 2005                 2010             


Ile Gln  Phe Leu Asn Phe Ser  Thr Glu Ala Asn His  Asp Phe Leu 
    2015                 2020                 2025             


Glu Ile  Gln Asn Gly Pro Tyr  His Thr Ser Pro Met  Ile Gly Gln 
    2030                 2035                 2040             


Phe Ser  Gly Thr Asp Leu Pro  Ala Ala Leu Leu Ser  Thr Thr His 
    2045                 2050                 2055             


Glu Thr  Leu Ile His Phe Tyr  Ser Asp His Ser Gln  Asn Arg Gln 
    2060                 2065                 2070             


Gly Phe  Lys Leu Ala Tyr Gln  Ala Tyr Glu Leu Gln  Asn Cys Pro 
    2075                 2080                 2085             


Asp Pro  Pro Pro Phe Gln Asn  Gly Tyr Met Ile Asn  Ser Asp Tyr 
    2090                 2095                 2100             


Ser Val  Gly Gln Ser Val Ser  Phe Glu Cys Tyr Pro  Gly Tyr Ile 
    2105                 2110                 2115             


Leu Ile  Gly His Pro Val Leu  Thr Cys Gln His Gly  Ile Asn Arg 
    2120                 2125                 2130             


Asn Trp  Asn Tyr Pro Phe Pro  Arg Cys Asp Ala Pro  Cys Gly Tyr 
    2135                 2140                 2145             


Asn Val  Thr Ser Gln Asn Gly  Thr Ile Tyr Ser Pro  Gly Phe Pro 
    2150                 2155                 2160             


Asp Glu  Tyr Pro Ile Leu Lys  Asp Cys Ile Trp Leu  Ile Thr Val 
    2165                 2170                 2175             


Pro Pro  Gly His Gly Val Tyr  Ile Asn Phe Thr Leu  Leu Gln Thr 
    2180                 2185                 2190             


Glu Ala  Val Asn Asp Tyr Ile  Ala Val Trp Asp Gly  Pro Asp Gln 
    2195                 2200                 2205             


Asn Ser  Pro Gln Leu Gly Val  Phe Ser Gly Asn Thr  Ala Leu Glu 
    2210                 2215                 2220             


Thr Ala  Tyr Ser Ser Thr Asn  Gln Val Leu Leu Lys  Phe His Ser 
    2225                 2230                 2235             


Asp Phe  Ser Asn Gly Gly Phe  Phe Val Leu Asn Phe  His Ala Phe 
    2240                 2245                 2250             


Gln Leu  Lys Lys Cys Gln Pro  Pro Pro Ala Val Pro  Gln Ala Glu 
    2255                 2260                 2265             


Met Leu  Thr Glu Asp Asp Asp  Phe Glu Ile Gly Asp  Phe Val Lys 
    2270                 2275                 2280             


Tyr Gln  Cys His Pro Gly Tyr  Thr Leu Val Gly Thr  Asp Ile Leu 
    2285                 2290                 2295             


Thr Cys  Lys Leu Ser Ser Gln  Leu Gln Phe Glu Gly  Ser Leu Pro 
    2300                 2305                 2310             


Thr Cys  Glu Ala Gln Cys Pro  Ala Asn Glu Val Arg  Thr Gly Ser 
    2315                 2320                 2325             


Ser Gly  Val Ile Leu Ser Pro  Gly Tyr Pro Gly Asn  Tyr Phe Asn 
    2330                 2335                 2340             


Ser Gln  Thr Cys Ser Trp Ser  Ile Lys Val Glu Pro  Asn Tyr Asn 
    2345                 2350                 2355             


Ile Thr  Ile Phe Val Asp Thr  Phe Gln Ser Glu Lys  Gln Phe Asp 
    2360                 2365                 2370             


Ala Leu  Glu Val Phe Asp Gly  Ser Ser Gly Gln Ser  Pro Leu Leu 
    2375                 2380                 2385             


Val Val  Leu Ser Gly Asn His  Thr Glu Gln Ser Asn  Phe Thr Ser 
    2390                 2395                 2400             


Arg Ser  Asn Gln Leu Tyr Leu  Arg Trp Ser Thr Asp  His Ala Thr 
    2405                 2410                 2415             


Ser Lys  Lys Gly Phe Lys Ile  Arg Tyr Ala Ala Pro  Tyr Cys Ser 
    2420                 2425                 2430             


Leu Thr  His Pro Leu Lys Asn  Gly Gly Ile Leu Asn  Arg Thr Ala 
    2435                 2440                 2445             


Gly Ala  Val Gly Ser Lys Val  His Tyr Phe Cys Lys  Pro Gly Tyr 
    2450                 2455                 2460             


Arg Met  Val Gly His Ser Asn  Ala Thr Cys Arg Arg  Asn Pro Leu 
    2465                 2470                 2475             


Gly Met  Tyr Gln Trp Asp Ser  Leu Thr Pro Leu Cys  Gln Ala Val 
    2480                 2485                 2490             


Ser Cys  Gly Ile Pro Glu Ser  Pro Gly Asn Gly Ser  Phe Thr Gly 
    2495                 2500                 2505             


Asn Glu  Phe Thr Leu Asp Ser  Lys Val Val Tyr Glu  Cys His Glu 
    2510                 2515                 2520             


Gly Phe  Lys Leu Glu Ser Ser  Gln Gln Ala Thr Ala  Val Cys Gln 
    2525                 2530                 2535             


Glu Asp  Gly Leu Trp Ser Asn  Lys Gly Lys Pro Pro  Thr Cys Lys 
    2540                 2545                 2550             


Pro Val  Ala Cys Pro Ser Ile  Glu Ala Gln Leu Ser  Glu His Val 
    2555                 2560                 2565             


Ile Trp  Arg Leu Val Ser Gly  Ser Leu Asn Glu Tyr  Gly Ala Gln 
    2570                 2575                 2580             


Val Leu  Leu Ser Cys Ser Pro  Gly Tyr Tyr Leu Glu  Gly Trp Arg 
    2585                 2590                 2595             


Leu Leu  Arg Cys Gln Ala Asn  Gly Thr Trp Asn Ile  Gly Asp Glu 
    2600                 2605                 2610             


Arg Pro  Ser Cys Arg Val Ile  Ser Cys Gly Ser Leu  Ser Phe Pro 
    2615                 2620                 2625             


Pro Asn  Gly Asn Lys Ile Gly  Thr Leu Thr Val Tyr  Gly Ala Thr 
    2630                 2635                 2640             


Ala Ile  Phe Thr Cys Asn Thr  Gly Tyr Thr Leu Val  Gly Ser His 
    2645                 2650                 2655             


Val Arg  Glu Cys Leu Ala Asn  Gly Leu Trp Ser Gly  Ser Glu Thr 
    2660                 2665                 2670             


Arg Cys  Leu Ala Gly His Cys  Gly Ser Pro Asp Pro  Ile Val Asn 
    2675                 2680                 2685             


Gly His  Ile Ser Gly Asp Gly  Phe Ser Tyr Arg Asp  Thr Val Val 
    2690                 2695                 2700             


Tyr Gln  Cys Asn Pro Gly Phe  Arg Leu Val Gly Thr  Ser Val Arg 
    2705                 2710                 2715             


Ile Cys  Leu Gln Asp His Lys  Trp Ser Gly Gln Thr  Pro Val Cys 
    2720                 2725                 2730             


Val Pro  Ile Thr Cys Gly His  Pro Gly Asn Pro Ala  His Gly Phe 
    2735                 2740                 2745             


Thr Asn  Gly Ser Glu Phe Asn  Leu Asn Asp Val Val  Asn Phe Thr 
    2750                 2755                 2760             


Cys Asn  Thr Gly Tyr Leu Leu  Gln Gly Val Ser Arg  Ala Gln Cys 
    2765                 2770                 2775             


Arg Ser  Asn Gly Gln Trp Ser  Ser Pro Leu Pro Thr  Cys Arg Val 
    2780                 2785                 2790             


Val Asn  Cys Ser Asp Pro Gly  Phe Val Glu Asn Ala  Ile Arg His 
    2795                 2800                 2805             


Gly Gln  Gln Asn Phe Pro Glu  Ser Phe Glu Tyr Gly  Met Ser Ile 
    2810                 2815                 2820             


Leu Tyr  His Cys Lys Lys Gly  Phe Tyr Leu Leu Gly  Ser Ser Ala 
    2825                 2830                 2835             


Leu Thr  Cys Met Ala Asn Gly  Leu Trp Asp Arg Ser  Leu Pro Lys 
    2840                 2845                 2850             


Cys Leu  Ala Ile Ser Cys Gly  His Pro Gly Val Pro  Ala Asn Ala 
    2855                 2860                 2865             


Val Leu  Thr Gly Glu Leu Phe  Thr Tyr Gly Ala Val  Val His Tyr 
    2870                 2875                 2880             


Ser Cys  Arg Gly Ser Glu Ser  Leu Ile Gly Asn Asp  Thr Arg Val 
    2885                 2890                 2895             


Cys Gln  Glu Asp Ser His Trp  Ser Gly Ala Leu Pro  His Cys Thr 
    2900                 2905                 2910             


Gly Asn  Asn Pro Gly Phe Cys  Gly Asp Pro Gly Thr  Pro Ala His 
    2915                 2920                 2925             


Gly Ser  Arg Leu Gly Asp Asp  Phe Lys Thr Lys Ser  Leu Leu Arg 
    2930                 2935                 2940             


Phe Ser  Cys Glu Met Gly His  Gln Leu Arg Gly Ser  Pro Glu Arg 
    2945                 2950                 2955             


Thr Cys  Leu Leu Asn Gly Ser  Trp Ser Gly Leu Gln  Pro Val Cys 
    2960                 2965                 2970             


Glu Ala  Val Ser Cys Gly Asn  Pro Gly Thr Pro Thr  Asn Gly Met 
    2975                 2980                 2985             


Ile Val  Ser Ser Asp Gly Ile  Leu Phe Ser Ser Ser  Val Ile Tyr 
    2990                 2995                 3000             


Ala Cys  Trp Glu Gly Tyr Lys  Thr Ser Gly Leu Met  Thr Arg His 
    3005                 3010                 3015             


Cys Thr  Ala Asn Gly Thr Trp  Thr Gly Thr Ala Pro  Asp Cys Thr 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Asp Pro  Gly Thr Leu Ala Asn  Gly Ile Gln 
    3035                 3040                 3045             


Phe Gly  Thr Asp Phe Thr Phe  Asn Lys Thr Val Ser  Tyr Gln Cys 
    3050                 3055                 3060             


Asn Pro  Gly Tyr Val Met Glu  Ala Val Thr Ser Ala  Thr Ile Arg 
    3065                 3070                 3075             


Cys Thr  Lys Asp Gly Arg Trp  Asn Pro Ser Lys Pro  Val Cys Lys 
    3080                 3085                 3090             


Ala Val  Leu Cys Pro Gln Pro  Pro Pro Val Gln Asn  Gly Thr Val 
    3095                 3100                 3105             


Glu Gly  Ser Asp Phe Arg Trp  Gly Ser Ser Ile Ser  Tyr Ser Cys 
    3110                 3115                 3120             


Met Asp  Gly Tyr Gln Leu Ser  His Ser Ala Ile Leu  Ser Cys Glu 
    3125                 3130                 3135             


Gly Arg  Gly Val Trp Lys Gly  Glu Ile Pro Gln Cys  Leu Pro Val 
    3140                 3145                 3150             


Phe Cys  Gly Asp Pro Gly Ile  Pro Ala Glu Gly Arg  Leu Ser Gly 
    3155                 3160                 3165             


Lys Ser  Phe Thr Tyr Lys Ser  Glu Val Phe Phe Gln  Cys Lys Ser 
    3170                 3175                 3180             


Pro Phe  Ile Leu Val Gly Ser  Ser Arg Arg Val Cys  Gln Ala Asp 
    3185                 3190                 3195             


Gly Thr  Trp Ser Gly Ile Gln  Pro Thr Cys Ile Asp  Pro Ala His 
    3200                 3205                 3210             


Asn Thr  Cys Pro Asp Pro Gly  Thr Pro His Phe Gly  Ile Gln Asn 
    3215                 3220                 3225             


Ser Ser  Arg Gly Tyr Glu Val  Gly Ser Thr Val Phe  Phe Arg Cys 
    3230                 3235                 3240             


Arg Lys  Gly Tyr His Ile Gln  Gly Ser Thr Thr Arg  Thr Cys Leu 
    3245                 3250                 3255             


Ala Asn  Leu Thr Trp Ser Gly  Ile Gln Thr Glu Cys  Ile Pro His 
    3260                 3265                 3270             


Ala Cys  Arg Gln Pro Glu Thr  Pro Ala His Ala Asp  Val Arg Ala 
    3275                 3280                 3285             


Ile Asp  Leu Pro Thr Phe Gly  Tyr Thr Leu Val Tyr  Thr Cys His 
    3290                 3295                 3300             


Pro Gly  Phe Phe Leu Ala Gly  Gly Ser Glu His Arg  Thr Cys Lys 
    3305                 3310                 3315             


Ala Asp  Met Lys Trp Thr Gly  Lys Ser Pro Val Cys  Lys Ser Lys 
    3320                 3325                 3330             


Gly Val  Arg Glu Val Asn Glu  Thr Val Thr Lys Thr  Pro Val Pro 
    3335                 3340                 3345             


Ser Asp  Val Phe Phe Val Asn  Ser Leu Trp Lys Gly  Tyr Tyr Glu 
    3350                 3355                 3360             


Tyr Leu  Gly Lys Arg Gln Pro  Ala Thr Leu Thr Val  Asp Trp Phe 
    3365                 3370                 3375             


Asn Ala  Thr Ser Ser Lys Val  Asn Ala Thr Phe Ser  Glu Ala Ser 
    3380                 3385                 3390             


Pro Val  Glu Leu Lys Leu Thr  Gly Ile Tyr Lys Lys  Glu Glu Ala 
    3395                 3400                 3405             


His Leu  Leu Leu Lys Ala Phe  Gln Ile Lys Gly Gln  Ala Asp Ile 
    3410                 3415                 3420             


Phe Val  Ser Lys Phe Glu Asn  Asp Asn Trp Gly Leu  Asp Gly Tyr 
    3425                 3430                 3435             


Val Ser  Ser Gly Leu Glu Arg  Gly Gly Phe Thr Phe  Gln Gly Asp 
    3440                 3445                 3450             


Ile His  Gly Lys Asp Phe Gly  Lys Phe Lys Leu Glu  Arg Gln Asp 
    3455                 3460                 3465             


Pro Leu  Asn Pro Asp Gln Asp  Ser Ser Ser His Tyr  His Gly Thr 
    3470                 3475                 3480             


Ser Ser  Gly Ser Val Ala Ala  Ala Ile Leu Val Pro  Phe Phe Ala 
    3485                 3490                 3495             


Leu Ile  Leu Ser Gly Phe Ala  Phe Tyr Leu Tyr Lys  His Arg Thr 
    3500                 3505                 3510             


Arg Pro  Lys Val Gln Tyr Asn  Gly Tyr Ala Gly His  Glu Asn Ser 
    3515                 3520                 3525             


Asn Gly  Gln Ala Ser Phe Glu  Asn Pro Met Tyr Asp  Thr Asn Leu 
    3530                 3535                 3540             


Lys Pro  Thr Glu Ala Lys Ala  Val Arg Phe Asp Thr  Thr Leu Asn 
    3545                 3550                 3555             


Thr Val  Cys Thr Val Val 
    3560                 


<210>  309
<211>  4129
<212>  DNA
<213>  Homo sapiens

<400>  309
ctccacggca gcggctcctt gtgccactag cagcccttct tctgcgctct ccgccttttc       60

tctctagact ggatctctcc tcccccccgc gcccccctcc ccgcatctcc cactcgctgg      120

ctctctctcc agctgcctcc tctccaggtc tctcctggct gcgcgcgctc ctctccccgc      180

ttctccccct cccgcagcct cgccgccttg gtgccttcct gcccggctcg gccggcgctc      240

gtccccggcc ccggccccgc cagcccgggt ctccgcgctc ggagcagctc agccctgcag      300

tggctcggga cccgatgcta tgagagggaa gcgagccggg cgcccagacc ttcaggaggc      360

gtcggatgcg cggcgggtct tgggaccggg ctctctctcc ggctcgcctt gccctcgggt      420

gattatttgg ctccgctcat agccctgcct tcctcggagg agccatcggt gtcgcgtgcg      480

tgtggagtat ctgcagacat gactgcgtgg aggagattcc agtcgctgct cctgcttctc      540

gggctgctgg tgctgtgcgc gaggctcctc actgcagcga agggtcagaa ctgtggaggc      600

ttagtccagg gtcccaatgg cactattgag agcccagggt ttcctcacgg gtatccgaac      660

tatgccaact gcacctggat catcatcacg ggcgagcgca ataggataca gttgtccttc      720

catacctttg ctcttgaaga agattttgat attttatcag tttacgatgg acagcctcaa      780

caagggaatt taaaagtgag attatcggga tttcagctgc cctcctctat agtgagtaca      840

ggatctatcc tcactctgtg gttcacgaca gacttcgctg tgagtgccca aggtttcaaa      900

gcattatatg aagttttacc tagccacact tgtggaaatc ctggagaaat cctgaaagga      960

gttctgcatg gaacgagatt caacatagga gacaaaatcc ggtacagctg cctccctggc     1020

tacatcttgg aaggccacgc catcctgacc tgcatcgtca gcccaggaaa tggtgcatcg     1080

tgggacttcc cagctccctt ttgcagagct gagggagcct gcggaggaac cttacgcggg     1140

accagcagct ccatctccag cccgcacttc ccttcagagt acgagaacaa cgcggactgc     1200

acctggacca ttctggctga gcccggggac accattgcgc tggtcttcac tgactttcag     1260

ctagaagaag gatatgattt cttagagatc agtggcacgg aagctccatc catatggcta     1320

actggcatga acctcccctc tccagttatc agtagcaaga attggctacg actccatttc     1380

acctctgaca gcaaccaccg acgcaaagga tttaacgctc agttccaagt gaaaaaggcg     1440

attgagttga agtcaagagg agtcaagatg ctgcccagca aggatggaag ccataaaaac     1500

tctgtcttga gccaaggagg tgttgcattg gtctctgaca tgtgtccaga tcctgggatt     1560

ccagaaaatg gtagaagagc aggttccgac ttcagggttg gtgcaaatgt acagttttca     1620

tgtgaggaca attacgtgct ccagggatct aaaagcatca cctgtcagag agttacagag     1680

acgctcgctg cttggagtga ccacaggccc atctgccgag cgagaacatg tggatccaat     1740

ctgcgtgggc ccagcggcgt cattacctcc cctaattatc cggttcagta tgaagataat     1800

gcacactgtg tgtgggtcat caccaccacc gacccggaca aggtcatcaa gcttgccttt     1860

gaagagtttg agctggagcg aggctatgac accctgacgg ttggtgatgc tgggaaggtg     1920

ggagacacca gatcggtctt gtacgtgctc acgggatcca gtgttcctga cctcattgtg     1980

agcatgagca accagatgtg gctacatctg cagtcggatg atagcattgg ctcacctggg     2040

tttaaagctg tttaccaaga aattgaaaag ggagggtgtg gggatcctgg aatccccgcc     2100

tatgggaagc ggacgggcag cagtttcctc catggagata cactcacctt tgaatgcccg     2160

gcggcctttg agctggtggg ggagagagtt atcacctgtc agcagaacaa tcagtggtct     2220

ggcaacaagc ccagctgtgt attttcatgt ttcttcaact ttacggcatc atctgggatt     2280

attctgtcac caaattatcc agaggaatat gggaacaaca tgaactgtgt ctggttgatt     2340

atctcggagc caggaagtcg aattcaccta atctttaatg attttgatgt tgagcctcag     2400

tttgactttc tcgcggtcaa ggatgatggc atttctgaca taactgtcct gggtactttt     2460

tctggcaatg aagtgccttc ccagctggcc agcagtgggc atatagttcg cttggaattt     2520

cagtctgacc attccactac tggcagaggg ttcaacatca cttacaccac atttggtcag     2580

aatgagtgcc atgatcctgg cattcctata aacggacgac gttttggtga caggtttcta     2640

ctcgggagct cggtttcttt ccactgtgat gatggctttg tcaagaccca gggatccgag     2700

tccattacct gcatactgca agacgggaac gtggtctgga gctccaccgt gccccgctgt     2760

gaagctccat gtggtggaca tctgacagcg tccagcggag tcattttgcc tcctggatgg     2820

ccaggatatt ataaggattc tttacattgt gaatggataa ttgaagcaaa accaggccac     2880

tctatcaaaa taacttttga cagatttcag acagaggtca attatgacac cttggaggtc     2940

agagatgggc cagccagttc gtccccactg atcggcgagt accacggcac ccaggcaccc     3000

cagttcctca tcagcaccgg gaacttcatg tacctgctgt tcaccactga caacagccgc     3060

tccagcatcg gcttcctcat ccactatgag agtgtgacgc ttgagtcgga ttcctgcctg     3120

gacccgggca tccctgtgaa cggccatcgc cacggtggag actttggcat caggtccaca     3180

gtgactttca gctgtgaccc ggggtacaca ctaagtgacg acgagcccct cgtctgtgag     3240

aggaaccacc agtggaacca cgccttgccc agctgcgacg ctctatgtgg aggctacatc     3300

caagggaaga gtggaacagt cctttctcct gggtttccag atttttatcc aaactctcta     3360

aactgcacgt ggaccattga agtgtctcat gggaaaggag ttcaaatgat ctttcacacc     3420

tttcatcttg agagttccca cgactattta ctgatcacag aggatggaag tttttccgag     3480

cccgttgcca ggctcaccgg gtcggtgttg cctcatacga tcaaggcagg cctgtttgga     3540

aacttcactg cccagcttcg gtttatatca gacttctcaa tttcgtacga gggcttcaat     3600

atcacatttt cagaatatga cctggagcca tgtgatgatc ctggagtccc tgccttcagc     3660

cgaagaattg gttttcactt tggtgtggga gactctctga cgttttcctg cttcctggga     3720

tatcgtttag aaggtgccac caagcttacc tgcctgggtg ggggccgccg tgtgtggagt     3780

gcacctctgc caaggtgtgt ggccgaatgt ggagcaagtg tcaaaggaaa tgaaggaaca     3840

ttactgtctc caaattttcc atccaattat gataataacc atgagtgtat ctataaaata     3900

gaaacagaag ccggcaaggg catccacctt agaacacgaa gcttccagct gtttgaagga     3960

gatactctaa aggtatatga tggaaaagac agttcctcac gtccactggg cacgttcact     4020

aaaaatgaac ttctggggct gatcctaaac agcacatcca atcacctgtg gctagagttc     4080

aacaccaatg gatctgacac cgaccaaggt tttcaactca cctatacca                 4129


<210>  310
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys 
            20                  25                  30          


Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe 
        35                  40                  45              


Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr 
    50                  55                  60                  


Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu 
65                  70                  75                  80  


Glu Asp Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly 
                85                  90                  95      


Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val 
            100                 105                 110         


Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val 
        115                 120                 125             


Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr 
    130                 135                 140                 


Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg 
145                 150                 155                 160 


Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile 
                165                 170                 175     


Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly 
            180                 185                 190         


Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys 
        195                 200                 205             


Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe 
    210                 215                 220                 


Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala 
225                 230                 235                 240 


Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu 
                245                 250                 255     


Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile 
            260                 265                 270         


Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn 
        275                 280                 285             


Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly 
    290                 295                 300                 


Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg 
305                 310                 315                 320 


Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val 
                325                 330                 335     


Leu Ser Gln Gly Gly Val Ala Leu Val Ser Asp Met Cys Pro Asp Pro 
            340                 345                 350         


Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Arg Val Gly 
        355                 360                 365             


Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly Ser 
    370                 375                 380                 


Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp Ser 
385                 390                 395                 400 


Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu Arg 
                405                 410                 415     


Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr Glu 
            420                 425                 430         


Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp Lys 
        435                 440                 445             


Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr Asp 
    450                 455                 460                 


Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser Val 
465                 470                 475                 480 


Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser Met 
                485                 490                 495     


Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly Ser 
            500                 505                 510         


Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys Gly 
        515                 520                 525             


Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe Leu 
    530                 535                 540                 


His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu Val 
545                 550                 555                 560 


Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly Asn 
                565                 570                 575     


Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser Ser 
            580                 585                 590         


Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn Met 
        595                 600                 605             


Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His Leu 
    610                 615                 620                 


Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala Val 
625                 630                 635                 640 


Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser Gly 
                645                 650                 655     


Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg Leu 
            660                 665                 670         


Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile Thr 
        675                 680                 685             


Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro Ile 
    690                 695                 700                 


Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val Ser 
705                 710                 715                 720 


Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser Ile 
                725                 730                 735     


Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val Pro 
            740                 745                 750         


Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly Val 
        755                 760                 765             


Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His Cys 
    770                 775                 780                 


Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr Phe 
785                 790                 795                 800 


Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg Asp 
                805                 810                 815     


Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr Gln 
            820                 825                 830         


Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu Phe 
        835                 840                 845             


Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr Glu 
    850                 855                 860                 


Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro Val 
865                 870                 875                 880 


Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val Thr 
                885                 890                 895     


Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu Val 
            900                 905                 910         


Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp Ala 
        915                 920                 925             


Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser Pro 
    930                 935                 940                 


Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr Ile 
945                 950                 955                 960 


Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe His 
                965                 970                 975     


Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe 
            980                 985                 990         


Ser Glu Pro Val Ala Arg Leu Thr  Gly Ser Val Leu Pro  His Thr Ile 
        995                 1000                 1005             


Lys Ala  Gly Leu Phe Gly Asn  Phe Thr Ala Gln Leu  Arg Phe Ile 
    1010                 1015                 1020             


Ser Asp  Phe Ser Ile Ser Tyr  Glu Gly Phe Asn Ile  Thr Phe Ser 
    1025                 1030                 1035             


Glu Tyr  Asp Leu Glu Pro Cys  Asp Asp Pro Gly Val  Pro Ala Phe 
    1040                 1045                 1050             


Ser Arg  Arg Ile Gly Phe His  Phe Gly Val Gly Asp  Ser Leu Thr 
    1055                 1060                 1065             


Phe Ser  Cys Phe Leu Gly Tyr  Arg Leu Glu Gly Ala  Thr Lys Leu 
    1070                 1075                 1080             


Thr Cys  Leu Gly Gly Gly Arg  Arg Val Trp Ser Ala  Pro Leu Pro 
    1085                 1090                 1095             


Arg Cys  Val Ala Glu Cys Gly  Ala Ser Val Lys Gly  Asn Glu Gly 
    1100                 1105                 1110             


Thr Leu  Leu Ser Pro Asn Phe  Pro Ser Asn Tyr Asp  Asn Asn His 
    1115                 1120                 1125             


Glu Cys  Ile Tyr Lys Ile Glu  Thr Glu Ala Gly Lys  Gly Ile His 
    1130                 1135                 1140             


Leu Arg  Thr Arg Ser Phe Gln  Leu Phe Glu Gly Asp  Thr Leu Lys 
    1145                 1150                 1155             


Val Tyr  Asp Gly Lys Asp Ser  Ser Ser Arg Pro Leu  Gly Thr Phe 
    1160                 1165                 1170             


Thr Lys  Asn Glu Leu Leu Gly  Leu Ile Leu Asn Ser  Thr Ser Asn 
    1175                 1180                 1185             


His Leu  Trp Leu Glu Phe Asn  Thr Asn Gly Ser Asp  Thr Asp Gln 
    1190                 1195                 1200             


Gly Phe  Gln Leu Thr Tyr Thr  
    1205                 1210 


<210>  311
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  311
ccagaactgg aagtctgaag cgagccctgc acaatgccga atgccagaag actgtcacca       60

tctccaagcc ctgtggcaaa ctgaccaagc ccaaacctca ag                         102


<210>  312
<211>  103
<212>  DNA
<213>  Homo sapiens

<400>  312
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaaccagt tctgaatact cctctctcag att                        103


<210>  313
<211>  205
<212>  DNA
<213>  Homo sapiens

<400>  313
ccagaactgg aagtctgaag cgagccctgc acaatgccga atgccagaag actgtcacca       60

tctccaagcc ctgtggcaaa ctgaccaagc ccaaacctca agccttgcct ccccgattga      120

aagagatgaa aagccaggaa tcggctgcag gttccaaact agtccttcgg tgtgaaacca      180

gttctgaata ctcctctctc agatt                                            205


<210>  314
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  314

Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn Ala Glu Cys Gln Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu Thr Lys Pro Lys Pro 
            20                  25                  30          


Gln Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg 
65          


<210>  315
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  315
aaggggaaat aagggacaag agagaccctc tcatattgtt ttatattatt tcatactcag       60

aaaaggaaag agaagccaaa caaaaggcag gtaacccagc gcctaggaac cagacccgaa      120

accaaggaac cagatctgaa accaggcctg ggcctgcctg acctaagcct ggtagtaaaa      180

attccacccc tgacctgacc tggcaactgt tgttatctac agattccaga cattgtatgg      240

aaggacactg tgaaacctcc cgttctgttc tgtttcactc tgaccatcgg tgctcacagc      300

ccctatcacg taccccctgg cttgctcagt cgatcacgac cctctcacgt ggaccccctt      360

agagttgtta gcccttaaaa gggacagaag ttgagcacct gaggagctca gattttaaga      420

cgctaggctg ctgatgctcc cagctgatta aagccactcc cttcactatc tcggtgtctc      480

ctgtccgcgg ctcgtcctgc tacatttctt ggttccctga ccggcaagcg ag              532


<210>  316
<211>  116
<212>  DNA
<213>  Homo sapiens

<400>  316
aatgcaggct caacagtacc agcagcagcg tcgaaaattt gcagctgcct tcttggcatt       60

cattttcata ctggcagctg tggatactgc tgaagcaggg aagaaagaga aaccag          116


<210>  317
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  317
aaaaaaaagt gaagaagtct gactgtggag aatggcagtg gagtgtgtgt gtgcccacca       60

gtggagactg tgggctgggc acacgggagg gcactcggac tggagctgag tgcaagcaaa      120

ccatgaagac ccagagatgt aagatcccct gcaactggaa gaagcaattt ggcg            174


<210>  318
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  318
cggagtgcaa ataccagttc caggcctggg gagaatgtga cctgaacaca gccctgaaga       60

ccagaactgg aagtctgaag cgagccctgc acaatgccga atgccagaag actgtcacca      120

tctccaagcc ctgtggcaaa ctgaccaagc ccaaacctca ag                         162


<210>  319
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  319
cagaatctaa gaagaagaaa aaggaaggca agaaacagga gaagatgctg gattaaaaga       60

tgtcacctgt ggaacataaa aaggacatca gcaaacagga tcagttaact attgcattta      120

tatgtaccgt aggctttgta ttcaaaaatt atctatagct aagtacacaa taagcaaaaa      180

caaaaagaaa agaaaatttt tgtagtagcg ttttttaaat gtatactata gtaccagtag      240

gggcttataa taaaggactg taatcttatt taggaagttg acttatagta catgataaat      300

gatagacaat tgaggtaagt tttttgaaat tatgtgacat tttacattaa atttttttta      360

cattttttgg gcagcaattt aaatgttatg actatgtaaa ctacttctct tgttaggtaa      420

tttttttcac ctagattttt ttcccaattg agaaaaatat atactaaaca aaatagcaat      480

aaaacataat cactctattt gaagaaaata tcttgttttc tgccaataga ttttttaaaa      540

tgtagtcagc aaaatggggg tggggaagca gagcatgtcc tagttcaatg ttgacttttt      600

ttttttttaa agaaaagcat taagacataa aattctttca ctttggcaga agcatttgtt      660

ttcttgatga aattattttt ccatctgagg aaaaaaatac taggaaaata aatcaaggtg      720

atgctgaaaa aaaaa                                                       735


<210>  320
<211>  1719
<212>  DNA
<213>  Homo sapiens

<400>  320
aaggggaaat aagggacaag agagaccctc tcatattgtt ttatattatt tcatactcag       60

aaaaggaaag agaagccaaa caaaaggcag gtaacccagc gcctaggaac cagacccgaa      120

accaaggaac cagatctgaa accaggcctg ggcctgcctg acctaagcct ggtagtaaaa      180

attccacccc tgacctgacc tggcaactgt tgttatctac agattccaga cattgtatgg      240

aaggacactg tgaaacctcc cgttctgttc tgtttcactc tgaccatcgg tgctcacagc      300

ccctatcacg taccccctgg cttgctcagt cgatcacgac cctctcacgt ggaccccctt      360

agagttgtta gcccttaaaa gggacagaag ttgagcacct gaggagctca gattttaaga      420

cgctaggctg ctgatgctcc cagctgatta aagccactcc cttcactatc tcggtgtctc      480

ctgtccgcgg ctcgtcctgc tacatttctt ggttccctga ccggcaagcg agaatgcagg      540

ctcaacagta ccagcagcag cgtcgaaaat ttgcagctgc cttcttggca ttcattttca      600

tactggcagc tgtggatact gctgaagcag ggaagaaaga gaaaccagaa aaaaaagtga      660

agaagtctga ctgtggagaa tggcagtgga gtgtgtgtgt gcccaccagt ggagactgtg      720

ggctgggcac acgggagggc actcggactg gagctgagtg caagcaaacc atgaagaccc      780

agagatgtaa gatcccctgc aactggaaga agcaatttgg cgcggagtgc aaataccagt      840

tccaggcctg gggagaatgt gacctgaaca cagccctgaa gaccagaact ggaagtctga      900

agcgagccct gcacaatgcc gaatgccaga agactgtcac catctccaag ccctgtggca      960

aactgaccaa gcccaaacct caagcagaat ctaagaagaa gaaaaaggaa ggcaagaaac     1020

aggagaagat gctggattaa aagatgtcac ctgtggaaca taaaaaggac atcagcaaac     1080

aggatcagtt aactattgca tttatatgta ccgtaggctt tgtattcaaa aattatctat     1140

agctaagtac acaataagca aaaacaaaaa gaaaagaaaa tttttgtagt agcgtttttt     1200

aaatgtatac tatagtacca gtaggggctt ataataaagg actgtaatct tatttaggaa     1260

gttgacttat agtacatgat aaatgataga caattgaggt aagttttttg aaattatgtg     1320

acattttaca ttaaattttt tttacatttt ttgggcagca atttaaatgt tatgactatg     1380

taaactactt ctcttgttag gtaatttttt tcacctagat ttttttccca attgagaaaa     1440

atatatacta aacaaaatag caataaaaca taatcactct atttgaagaa aatatcttgt     1500

tttctgccaa tagatttttt aaaatgtagt cagcaaaatg ggggtgggga agcagagcat     1560

gtcctagttc aatgttgact tttttttttt ttaaagaaaa gcattaagac ataaaattct     1620

ttcactttgg cagaagcatt tgttttcttg atgaaattat ttttccatct gaggaaaaaa     1680

atactaggaa aataaatcaa ggtgatgctg aaaaaaaaa                            1719


<210>  321
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 
1               5                   10                  15      


Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 
            20                  25                  30          


Gly Lys Lys Glu Lys Pro 
        35              


<210>  322
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  322

Lys Lys Val Lys Lys Ser Asp Cys Gly Glu Trp Gln Trp Ser Val Cys 
1               5                   10                  15      


Val Pro Thr Ser Gly Asp Cys Gly Leu Gly Thr Arg Glu Gly Thr Arg 
            20                  25                  30          


Thr Gly Ala Glu Cys Lys Gln Thr Met Lys Thr Gln Arg Cys Lys Ile 
        35                  40                  45              


Pro Cys Asn Trp Lys Lys Gln Phe Gly 
    50                  55          


<210>  323
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  323

Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn Thr 
1               5                   10                  15      


Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn Ala 
            20                  25                  30          


Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu Thr 
        35                  40                  45              


Lys Pro Lys Pro Gln 
    50              


<210>  324
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  324

Glu Ser Lys Lys Lys Lys Lys Glu Gly Lys Lys Gln Glu Lys Met Leu 
1               5                   10                  15      


Asp 
    


<210>  325
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 
1               5                   10                  15      


Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 
            20                  25                  30          


Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 
        35                  40                  45              


Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 
    50                  55                  60                  


Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 
65                  70                  75                  80  


Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 
                85                  90                  95      


Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 
            100                 105                 110         


Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 
        115                 120                 125             


Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 
    130                 135                 140                 


Thr Lys Pro Lys Pro Gln Ala Glu Ser Lys Lys Lys Lys Lys Glu Gly 
145                 150                 155                 160 


Lys Lys Gln Glu Lys Met Leu Asp 
                165             


<210>  326
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  326
aaggggaaat aagggacaag agagaccctc tcatattgtt ttatattatt tcatactcag       60

aaaaggaaag agaagccaaa caaaaggcag gtaacccagc gcctaggaac cagacccgaa      120

accaaggaac cagatctgaa accaggcctg ggcctgcctg acctaagcct ggtagtaaaa      180

attccacccc tgacctgacc tggcaactgt tgttatctac agattccaga cattgtatgg      240

aaggacactg tgaaacctcc cgttctgttc tgtttcactc tgaccatcgg tgctcacagc      300

ccctatcacg taccccctgg cttgctcagt cgatcacgac cctctcacgt ggaccccctt      360

agagttgtta gcccttaaaa gggacagaag ttgagcacct gaggagctca gattttaaga      420

cgctaggctg ctgatgctcc cagctgatta aagccactcc cttcactatc tcggtgtctc      480

ctgtccgcgg ctcgtcctgc tacatttctt ggttccctga ccggcaagcg agaatgcagg      540

ctcaacagta ccagcagcag cgtcgaaaat ttgcagctgc cttcttggca ttcattttca      600

tactggcagc tgtggatact gctgaagcag ggaagaaaga gaaaccagaa aaaaaagtga      660

agaagtctga ctgtggagaa tggcagtgga gtgtgtgtgt gcccaccagt ggagactgtg      720

ggctgggcac acgggagggc actcggactg gagctgagtg caagcaaacc atgaagaccc      780

agagatgtaa gatcccctgc aactggaaga agcaatttgg cgcggagtgc aaataccagt      840

tccaggcctg gggagaatgt gacctgaaca cagccctgaa gaccagaact ggaagtctga      900

agcgagccct gcacaatgcc gaatgccaga agactgtcac catctccaag ccctgtggca      960

aactgaccaa gcccaaacct caag                                             984


<210>  327
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Gln Ala Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala 
1               5                   10                  15      


Phe Leu Ala Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala 
            20                  25                  30          


Gly Lys Lys Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly 
        35                  40                  45              


Glu Trp Gln Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu 
    50                  55                  60                  


Gly Thr Arg Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met 
65                  70                  75                  80  


Lys Thr Gln Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly 
                85                  90                  95      


Ala Glu Cys Lys Tyr Gln Phe Gln Ala Trp Gly Glu Cys Asp Leu Asn 
            100                 105                 110         


Thr Ala Leu Lys Thr Arg Thr Gly Ser Leu Lys Arg Ala Leu His Asn 
        115                 120                 125             


Ala Glu Cys Gln Lys Thr Val Thr Ile Ser Lys Pro Cys Gly Lys Leu 
    130                 135                 140                 


Thr Lys Pro Lys Pro Gln 
145                 150 


<210>  328
<211>  95
<212>  DNA
<213>  Homo sapiens

<400>  328
caacagcaac aagatcacag ttcgcttcca ctcagatcag tcctacaccg acaccggctt       60

cttagctgaa tacctctcct acgactccag tgacc                                  95


<210>  329
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  329
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgct                                           87


<210>  330
<211>  182
<212>  DNA
<213>  Homo sapiens

<400>  330
caacagcaac aagatcacag ttcgcttcca ctcagatcag tcctacaccg acaccggctt       60

cttagctgaa tacctctcct acgactccag tgaccctaca tctacatcca ccactgggac      120

aagccatctt gtaaaatgtg cggagaagga gaaaactttc tgtgtgaatg gaggggagtg      180

ct                                                                     182


<210>  331
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  331

Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp Gln Ser Tyr Thr 
1               5                   10                  15      


Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp Ser Ser Asp Pro 
            20                  25                  30          


Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu 
        35                  40                  45              


Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys 
    50                  55                  60  


<210>  332
<211>  279
<212>  DNA
<213>  Homo sapiens

<400>  332
gtgagagcgg agctgcagcc ggagaaagag gaagagggag agagagcgcg ccagggcgag       60

ggcaccgccg ccggtcgggc gcgctgggcc tgcccggaat cccgccgcct gcgccccgcg      120

ccccgcgccc tgcgggccat gggagccggc cgccggcagg gacgacgcct gtgagacccg      180

cgagcggcct cggggaccat ggggagcgat cgggcccgca agggcggagg gggcccgaag      240

gacttcggcg cgggactcaa gtacaactcc cggcacgag                             279


<210>  333
<211>  160
<212>  DNA
<213>  Homo sapiens

<400>  333
aaagtgaatg gcttggagga aggcgtggag ttcctgccag tcaacaacgt caagaaggtg       60

gaaaagcatg gcccggggcg ctgggtggtg ctggcagccg tgctgatcgg cctcctcttg      120

gtcttgctgg ggatcggctt cctggtgtgg catttgcagt                            160


<210>  334
<211>  128
<212>  DNA
<213>  Homo sapiens

<400>  334
accgggacgt gcgtgtccag aaggtcttca atggctacat gaggatcaca aatgagaatt       60

ttgtggatgc ctacgagaac tccaactcca ctgagtttgt aagcctggcc agcaaggtga      120

aggacgcg                                                               128


<210>  335
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  335
ctgaagctgc tgtacagcgg agtcccattc ctgggcccct accacaagga gtcggctgtg       60

acggccttca g                                                            71


<210>  336
<211>  158
<212>  DNA
<213>  Homo sapiens

<400>  336
cgagggcagc gtcatcgcct actactggtc tgagttcagc atcccgcagc acctggtgga       60

ggaggccgag cgcgtcatgg ccgaggagcg cgtagtcatg ctgcccccgc gggcgcgctc      120

cctgaagtcc tttgtggtca cctcagtggt ggctttcc                              158


<210>  337
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  337
ccacggactc caaaacagta cagaggaccc aggaca                                 36


<210>  338
<211>  241
<212>  DNA
<213>  Homo sapiens

<400>  338
acagctgcag ctttggcctg cacgcccgcg gtgtggagct gatgcgcttc accacgcccg       60

gcttccctga cagcccctac cccgctcatg cccgctgcca gtgggccctg cggggggacg      120

ccgactcagt gctgagcctc accttccgca gctttgacct tgcgtcctgc gacgagcgcg      180

gcagcgacct ggtgacggtg tacaacaccc tgagccccat ggagccccac gccctggtgc      240

a                                                                      241


<210>  339
<211>  140
<212>  DNA
<213>  Homo sapiens

<400>  339
gttgtgtggc acctaccctc cctcctacaa cctgaccttc cactcctccc agaacgtcct       60

gctcatcaca ctgataacca acactgagcg gcggcatccc ggctttgagg ccaccttctt      120

ccagctgcct aggatgagca                                                  140


<210>  340
<211>  98
<212>  DNA
<213>  Homo sapiens

<400>  340
gctgtggagg ccgcttacgt aaagcccagg ggacattcaa cagcccctac tacccaggcc       60

actacccacc caacattgac tgcacatgga acattgag                               98


<210>  341
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  341
gtgcccaaca accagcatgt gaaggtgcgc ttcaaattct tctacctgct ggagcccggc       60

gtgcctgcgg gcacctgccc caaggactac gtggagatca acggggagaa                 110


<210>  342
<211>  131
<212>  DNA
<213>  Homo sapiens

<400>  342
atactgcgga gagaggtccc agttcgtcgt caccagcaac agcaacaaga tcacagttcg       60

cttccactca gatcagtcct acaccgacac cggcttctta gctgaatacc tctcctacga      120

ctccagtgac c                                                           131


<210>  343
<211>  105
<212>  DNA
<213>  Homo sapiens

<400>  343
catgcccggg gcagttcacg tgccgcacgg ggcggtgtat ccggaaggag ctgcgctgtg       60

atggctgggc cgactgcacc gaccacagcg atgagctcaa ctgca                      105


<210>  344
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  344
gttgcgacgc cggccaccag ttcacgtgca agaacaagtt ctgcaagccc ctcttctggg       60

tctgcgacag tgtgaacgac tgcggagaca acagcgacga gcaggggtgc a               111


<210>  345
<211>  114
<212>  DNA
<213>  Homo sapiens

<400>  345
gttgtccggc ccagaccttc aggtgttcca atgggaagtg cctctcgaaa agccagcagt       60

gcaatgggaa ggacgactgt ggggacgggt ccgacgaggc ctcctgcccc aagg            114


<210>  346
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  346
tgaacgtcgt cacttgtacc aaacacacct accgctgcct caatgggctc tgcttgagca       60

agggcaaccc tgagtgtgac gggaaggagg actgtagcga cggctcagat gagaaggact      120

gcg                                                                    123


<210>  347
<211>  187
<212>  DNA
<213>  Homo sapiens

<400>  347
actgtgggct gcggtcattc acgagacagg ctcgtgttgt tgggggcacg gatgcggatg       60

agggcgagtg gccctggcag gtaagcctgc atgctctggg ccagggccac atctgcggtg      120

cttccctcat ctctcccaac tggctggtct ctgccgcaca ctgctacatc gatgacagag      180

gattcag                                                                187


<210>  348
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  348
gtactcagac cccacgcagt ggacggcctt cctgggcttg cacgaccaga gccagcgcag       60

cgcccctggg gtgcaggagc gcaggctcaa gcgcatcatc tcccacccct tcttcaatga      120

cttcaccttc gactatgaca tcgcgctgct ggagctggag aaaccggcag agtacagctc      180

catggtgcgg cccatctgcc tgccggacgc ctcccatgtc ttccctgccg gcaaggccat      240

ctgggtcacg ggctggggac acacccagta tggag                                 275


<210>  349
<211>  137
<212>  DNA
<213>  Homo sapiens

<400>  349
gcactggcgc gctgatcctg caaaagggtg agatccgcgt catcaaccag accacctgcg       60

agaacctcct gccgcagcag atcacgccgc gcatgatgtg cgtgggcttc ctcagcggcg      120

gcgtggactc ctgccag                                                     137


<210>  350
<211>  701
<212>  DNA
<213>  Homo sapiens

<400>  350
ggtgattccg ggggacccct gtccagcgtg gaggcggatg ggcggatctt ccaggccggt       60

gtggtgagct ggggagacgg ctgcgctcag aggaacaagc caggcgtgta cacaaggctc      120

cctctgtttc gggactggat caaagagaac actggggtat aggggccggg gccacccaaa      180

tgtgtacacc tgcggggcca cccatcgtcc accccagtgt gcacgcctgc aggctggaga      240

ctggaccgct gactgcacca gcgcccccag aacatacact gtgaactcaa tctccagggc      300

tccaaatctg cctagaaaac ctctcgcttc ctcagcctcc aaagtggagc tgggaggtag      360

aaggggagga cactggtggt tctactgacc caactggggg caaaggtttg aagacacagc      420

ctcccccgcc agccccaagc tgggccgagg cgcgtttgtg catatctgcc tcccctgtct      480

ctaaggagca gcgggaacgg agcttcgggg cctcctcagt gaaggtggtg gggctgccgg      540

atctgggctg tggggccctt gggccacgct cttgaggaag cccaggctcg gaggaccctg      600

gaaaacagac gggtctgaga ctgaaattgt tttaccagct cccagggtgg acttcagtgt      660

gtgtatttgt gtaaatgagt aaaacatttt atttcttttt a                          701


<210>  351
<211>  3305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of ST14

<400>  351
gtgagagcgg agctgcagcc ggagaaagag gaagagggag agagagcgcg ccagggcgag       60

ggcaccgccg ccggtcgggc gcgctgggcc tgcccggaat cccgccgcct gcgccccgcg      120

ccccgcgccc tgcgggccat gggagccggc cgccggcagg gacgacgcct gtgagacccg      180

cgagcggcct cggggaccat ggggagcgat cgggcccgca agggcggagg gggcccgaag      240

gacttcggcg cgggactcaa gtacaactcc cggcacgaga aagtgaatgg cttggaggaa      300

ggcgtggagt tcctgccagt caacaacgtc aagaaggtgg aaaagcatgg cccggggcgc      360

tgggtggtgc tggcagccgt gctgatcggc ctcctcttgg tcttgctggg gatcggcttc      420

ctggtgtggc atttgcagta ccgggacgtg cgtgtccaga aggtcttcaa tggctacatg      480

aggatcacaa atgagaattt tgtggatgcc tacgagaact ccaactccac tgagtttgta      540

agcctggcca gcaaggtgaa ggacgcgctg aagctgctgt acagcggagt cccattcctg      600

ggcccctacc acaaggagtc ggctgtgacg gccttcagcg agggcagcgt catcgcctac      660

tactggtctg agttcagcat cccgcagcac ctggtggagg aggccgagcg cgtcatggcc      720

gaggagcgcg tagtcatgct gcccccgcgg gcgcgctccc tgaagtcctt tgtggtcacc      780

tcagtggtgg ctttccccac ggactccaaa acagtacaga ggacccagga caacagctgc      840

agctttggcc tgcacgcccg cggtgtggag ctgatgcgct tcaccacgcc cggcttccct      900

gacagcccct accccgctca tgcccgctgc cagtgggccc tgcgggggga cgccgactca      960

gtgctgagcc tcaccttccg cagctttgac cttgcgtcct gcgacgagcg cggcagcgac     1020

ctggtgacgg tgtacaacac cctgagcccc atggagcccc acgccctggt gcagttgtgt     1080

ggcacctacc ctccctccta caacctgacc ttccactcct cccagaacgt cctgctcatc     1140

acactgataa ccaacactga gcggcggcat cccggctttg aggccacctt cttccagctg     1200

cctaggatga gcagctgtgg aggccgctta cgtaaagccc aggggacatt caacagcccc     1260

tactacccag gccactaccc acccaacatt gactgcacat ggaacattga ggtgcccaac     1320

aaccagcatg tgaaggtgcg cttcaaattc ttctacctgc tggagcccgg cgtgcctgcg     1380

ggcacctgcc ccaaggacta cgtggagatc aacggggaga aatactgcgg agagaggtcc     1440

cagttcgtcg tcaccagcaa cagcaacaag atcacagttc gcttccactc agatcagtcc     1500

tacaccgaca ccggcttctt agctgaatac ctctcctacg actccagtga cccatgcccg     1560

gggcagttca cgtgccgcac ggggcggtgt atccggaagg agctgcgctg tgatggctgg     1620

gccgactgca ccgaccacag cgatgagctc aactgcagtt gcgacgccgg ccaccagttc     1680

acgtgcaaga acaagttctg caagcccctc ttctgggtct gcgacagtgt gaacgactgc     1740

ggagacaaca gcgacgagca ggggtgcagt tgtccggccc agaccttcag gtgttccaat     1800

gggaagtgcc tctcgaaaag ccagcagtgc aatgggaagg acgactgtgg ggacgggtcc     1860

gacgaggcct cctgccccaa ggtgaacgtc gtcacttgta ccaaacacac ctaccgctgc     1920

ctcaatgggc tctgcttgag caagggcaac cctgagtgtg acgggaagga ggactgtagc     1980

gacggctcag atgagaagga ctgcgactgt gggctgcggt cattcacgag acaggctcgt     2040

gttgttgggg gcacggatgc ggatgagggc gagtggccct ggcaggtaag cctgcatgct     2100

ctgggccagg gccacatctg cggtgcttcc ctcatctctc ccaactggct ggtctctgcc     2160

gcacactgct acatcgatga cagaggattc aggtactcag accccacgca gtggacggcc     2220

ttcctgggct tgcacgacca gagccagcgc agcgcccctg gggtgcagga gcgcaggctc     2280

aagcgcatca tctcccaccc cttcttcaat gacttcacct tcgactatga catcgcgctg     2340

ctggagctgg agaaaccggc agagtacagc tccatggtgc ggcccatctg cctgccggac     2400

gcctcccatg tcttccctgc cggcaaggcc atctgggtca cgggctgggg acacacccag     2460

tatggaggca ctggcgcgct gatcctgcaa aagggtgaga tccgcgtcat caaccagacc     2520

acctgcgaga acctcctgcc gcagcagatc acgccgcgca tgatgtgcgt gggcttcctc     2580

agcggcggcg tggactcctg ccagggtgat tccgggggac ccctgtccag cgtggaggcg     2640

gatgggcgga tcttccaggc cggtgtggtg agctggggag acggctgcgc tcagaggaac     2700

aagccaggcg tgtacacaag gctccctctg tttcgggact ggatcaaaga gaacactggg     2760

gtataggggc cggggccacc caaatgtgta cacctgcggg gccacccatc gtccacccca     2820

gtgtgcacgc ctgcaggctg gagactggac cgctgactgc accagcgccc ccagaacata     2880

cactgtgaac tcaatctcca gggctccaaa tctgcctaga aaacctctcg cttcctcagc     2940

ctccaaagtg gagctgggag gtagaagggg aggacactgg tggttctact gacccaactg     3000

ggggcaaagg tttgaagaca cagcctcccc cgccagcccc aagctgggcc gaggcgcgtt     3060

tgtgcatatc tgcctcccct gtctctaagg agcagcggga acggagcttc ggggcctcct     3120

cagtgaaggt ggtggggctg ccggatctgg gctgtggggc ccttgggcca cgctcttgag     3180

gaagcccagg ctcggaggac cctggaaaac agacgggtct gagactgaaa ttgttttacc     3240

agctcccagg gtggacttca gtgtgtgtat ttgtgtaaat gagtaaaaca ttttatttct     3300

tttta                                                                 3305


<210>  352
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu 
            20                  25          


<210>  353
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  353

Lys Val Asn Gly Leu Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn 
1               5                   10                  15      


Val Lys Lys Val Glu Lys His Gly Pro Gly Arg Trp Val Val Leu Ala 
            20                  25                  30          


Ala Val Leu Ile Gly Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu 
        35                  40                  45              


Val Trp His Leu Gln 
    50              


<210>  354
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  354

Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile Thr 
1               5                   10                  15      


Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu Phe 
            20                  25                  30          


Val Ser Leu Ala Ser Lys Val Lys Asp Ala 
        35                  40          


<210>  355
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  355

Leu Lys Leu Leu Tyr Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys 
1               5                   10                  15      


Glu Ser Ala Val Thr Ala Phe 
            20              


<210>  356
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  356

Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser Ile Pro Gln 
1               5                   10                  15      


His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu Arg Val Val 
            20                  25                  30          


Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val Val Thr Ser 
        35                  40                  45              


Val Val Ala Phe 
    50          


<210>  357
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  357

Thr Asp Ser Lys Thr Val Gln Arg Thr Gln Asp 
1               5                   10      


<210>  358
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  358

Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu Leu Met Arg Phe 
1               5                   10                  15      


Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala His Ala Arg Cys 
            20                  25                  30          


Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu Ser Leu Thr Phe 
        35                  40                  45              


Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly Ser Asp Leu Val 
    50                  55                  60                  


Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His Ala Leu Val 
65                  70                  75                  


<210>  359
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  359

Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr Phe His Ser Ser 
1               5                   10                  15      


Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr Glu Arg Arg His 
            20                  25                  30          


Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg Met Ser 
        35                  40                  45      


<210>  360
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  360

Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn Ser Pro Tyr 
1               5                   10                  15      


Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp Asn Ile Glu 
            20                  25                  30          


<210>  361
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  361

Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe Phe Tyr Leu 
1               5                   10                  15      


Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp Tyr Val Glu 
            20                  25                  30          


Ile Asn Gly Glu 
        35      


<210>  362
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  362

Tyr Cys Gly Glu Arg Ser Gln Phe Val Val Thr Ser Asn Ser Asn Lys 
1               5                   10                  15      


Ile Thr Val Arg Phe His Ser Asp Gln Ser Tyr Thr Asp Thr Gly Phe 
            20                  25                  30          


Leu Ala Glu Tyr Leu Ser Tyr Asp Ser Ser Asp 
        35                  40              


<210>  363
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  363

Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys Ile Arg Lys Glu 
1               5                   10                  15      


Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His Ser Asp Glu Leu 
            20                  25                  30          


Asn Cys 
        


<210>  364
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  364

Cys Asp Ala Gly His Gln Phe Thr Cys Lys Asn Lys Phe Cys Lys Pro 
1               5                   10                  15      


Leu Phe Trp Val Cys Asp Ser Val Asn Asp Cys Gly Asp Asn Ser Asp 
            20                  25                  30          


Glu Gln Gly Cys 
        35      


<210>  365
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  365

Cys Pro Ala Gln Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys 
1               5                   10                  15      


Ser Gln Gln Cys Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Ala Ser Cys Pro Lys 
        35          


<210>  366
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  366

Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn Gly Leu 
1               5                   10                  15      


Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp Cys Ser 
            20                  25                  30          


Asp Gly Ser Asp Glu Lys Asp Cys 
        35                  40  


<210>  367
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  367

Cys Gly Leu Arg Ser Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr 
1               5                   10                  15      


Asp Ala Asp Glu Gly Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu 
            20                  25                  30          


Gly Gln Gly His Ile Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu 
        35                  40                  45              


Val Ser Ala Ala His Cys Tyr Ile Asp Asp Arg Gly Phe 
    50                  55                  60      


<210>  368
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  368

Tyr Ser Asp Pro Thr Gln Trp Thr Ala Phe Leu Gly Leu His Asp Gln 
1               5                   10                  15      


Ser Gln Arg Ser Ala Pro Gly Val Gln Glu Arg Arg Leu Lys Arg Ile 
            20                  25                  30          


Ile Ser His Pro Phe Phe Asn Asp Phe Thr Phe Asp Tyr Asp Ile Ala 
        35                  40                  45              


Leu Leu Glu Leu Glu Lys Pro Ala Glu Tyr Ser Ser Met Val Arg Pro 
    50                  55                  60                  


Ile Cys Leu Pro Asp Ala Ser His Val Phe Pro Ala Gly Lys Ala Ile 
65                  70                  75                  80  


Trp Val Thr Gly Trp Gly His Thr Gln Tyr Gly 
                85                  90      


<210>  369
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  369

Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile Arg Val Ile Asn Gln 
1               5                   10                  15      


Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile Thr Pro Arg Met Met 
            20                  25                  30          


Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser Cys Gln 
        35                  40                  45  


<210>  370
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  370

Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly Arg Ile 
1               5                   10                  15      


Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln Arg Asn 
            20                  25                  30          


Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp Ile Lys 
        35                  40                  45              


Glu Asn Thr Gly Val 
    50              


<210>  371
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys 
    450                 455                 460                 


Ile Arg Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His 
465                 470                 475                 480 


Ser Asp Glu Leu Asn Cys Ser Cys Asp Ala Gly His Gln Phe Thr Cys 
                485                 490                 495     


Lys Asn Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn 
            500                 505                 510         


Asp Cys Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln 
        515                 520                 525             


Thr Phe Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys 
    530                 535                 540                 


Asn Gly Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro 
545                 550                 555                 560 


Lys Val Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn 
                565                 570                 575     


Gly Leu Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp 
            580                 585                 590         


Cys Ser Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser 
        595                 600                 605             


Phe Thr Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly 
    610                 615                 620                 


Glu Trp Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile 
625                 630                 635                 640 


Cys Gly Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His 
                645                 650                 655     


Cys Tyr Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp 
            660                 665                 670         


Thr Ala Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly 
        675                 680                 685             


Val Gln Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn 
    690                 695                 700                 


Asp Phe Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro 
705                 710                 715                 720 


Ala Glu Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser 
                725                 730                 735     


His Val Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His 
            740                 745                 750         


Thr Gln Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile 
        755                 760                 765             


Arg Val Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile 
    770                 775                 780                 


Thr Pro Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser 
785                 790                 795                 800 


Cys Gln Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly 
                805                 810                 815     


Arg Ile Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln 
            820                 825                 830         


Arg Asn Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp 
        835                 840                 845             


Ile Lys Glu Asn Thr Gly Val 
    850                 855 


<210>  372
<211>  1552
<212>  DNA
<213>  Homo sapiens

<400>  372
gtgagagcgg agctgcagcc ggagaaagag gaagagggag agagagcgcg ccagggcgag       60

ggcaccgccg ccggtcgggc gcgctgggcc tgcccggaat cccgccgcct gcgccccgcg      120

ccccgcgccc tgcgggccat gggagccggc cgccggcagg gacgacgcct gtgagacccg      180

cgagcggcct cggggaccat ggggagcgat cgggcccgca agggcggagg gggcccgaag      240

gacttcggcg cgggactcaa gtacaactcc cggcacgaga aagtgaatgg cttggaggaa      300

ggcgtggagt tcctgccagt caacaacgtc aagaaggtgg aaaagcatgg cccggggcgc      360

tgggtggtgc tggcagccgt gctgatcggc ctcctcttgg tcttgctggg gatcggcttc      420

ctggtgtggc atttgcagta ccgggacgtg cgtgtccaga aggtcttcaa tggctacatg      480

aggatcacaa atgagaattt tgtggatgcc tacgagaact ccaactccac tgagtttgta      540

agcctggcca gcaaggtgaa ggacgcgctg aagctgctgt acagcggagt cccattcctg      600

ggcccctacc acaaggagtc ggctgtgacg gccttcagcg agggcagcgt catcgcctac      660

tactggtctg agttcagcat cccgcagcac ctggtggagg aggccgagcg cgtcatggcc      720

gaggagcgcg tagtcatgct gcccccgcgg gcgcgctccc tgaagtcctt tgtggtcacc      780

tcagtggtgg ctttccccac ggactccaaa acagtacaga ggacccagga caacagctgc      840

agctttggcc tgcacgcccg cggtgtggag ctgatgcgct tcaccacgcc cggcttccct      900

gacagcccct accccgctca tgcccgctgc cagtgggccc tgcgggggga cgccgactca      960

gtgctgagcc tcaccttccg cagctttgac cttgcgtcct gcgacgagcg cggcagcgac     1020

ctggtgacgg tgtacaacac cctgagcccc atggagcccc acgccctggt gcagttgtgt     1080

ggcacctacc ctccctccta caacctgacc ttccactcct cccagaacgt cctgctcatc     1140

acactgataa ccaacactga gcggcggcat cccggctttg aggccacctt cttccagctg     1200

cctaggatga gcagctgtgg aggccgctta cgtaaagccc aggggacatt caacagcccc     1260

tactacccag gccactaccc acccaacatt gactgcacat ggaacattga ggtgcccaac     1320

aaccagcatg tgaaggtgcg cttcaaattc ttctacctgc tggagcccgg cgtgcctgcg     1380

ggcacctgcc ccaaggacta cgtggagatc aacggggaga aatactgcgg agagaggtcc     1440

cagttcgtcg tcaccagcaa cagcaacaag atcacagttc gcttccactc agatcagtcc     1500

tacaccgaca ccggcttctt agctgaatac ctctcctacg actccagtga cc             1552


<210>  373
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu His Ala Arg Gly Val Glu 
    210                 215                 220                 


Leu Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala 
225                 230                 235                 240 


His Ala Arg Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu 
                245                 250                 255     


Ser Leu Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly 
            260                 265                 270         


Ser Asp Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His 
        275                 280                 285             


Ala Leu Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr 
    290                 295                 300                 


Phe His Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr 
305                 310                 315                 320 


Glu Arg Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg 
                325                 330                 335     


Met Ser Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn 
            340                 345                 350         


Ser Pro Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp 
        355                 360                 365             


Asn Ile Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe 
    370                 375                 380                 


Phe Tyr Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp 
385                 390                 395                 400 


Tyr Val Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe 
                405                 410                 415     


Val Val Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp 
            420                 425                 430         


Gln Ser Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp 
        435                 440                 445             


Ser Ser Asp 
    450     


<210>  374
<211>  56
<212>  DNA
<213>  Homo sapiens

<400>  374
accctgtgaa ggcgaagcgc gggagaccaa agcctgcaag aaagacgcct gcccca           56


<210>  375
<211>  89
<212>  DNA
<213>  Homo sapiens

<400>  375
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgcttc                                         89


<210>  376
<211>  145
<212>  DNA
<213>  Homo sapiens

<400>  376
accctgtgaa ggcgaagcgc gggagaccaa agcctgcaag aaagacgcct gccccactac       60

atctacatcc accactggga caagccatct tgtaaaatgt gcggagaagg agaaaacttt      120

ctgtgtgaat ggaggggagt gcttc                                            145


<210>  377
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  377

Pro Cys Glu Gly Glu Ala Arg Glu Thr Lys Ala Cys Lys Lys Asp Ala 
1               5                   10                  15      


Cys Pro Thr Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys 
            20                  25                  30          


Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe 
        35                  40                  45              


<210>  378
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  378
agccgctgcg cccgagctgg cctgcgagtt cagggctcct gtcgctctcc aggagcaacc       60

tctactccgg acgcacaggc attccccgcg cccctccagc cctcgccgcc ctcgccaccg      120

ctcccggccg ccgcgctccg gtacacacag                                       150


<210>  379
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  379
gatccctgct gggcaccaac agctccacca tggggctggc ctggggacta ggcgtcctgt       60

tcctgatgca tgtgtgtggc accaaccgca ttccag                                 96


<210>  380
<211>  560
<212>  DNA
<213>  Homo sapiens

<400>  380
agtctggcgg agacaacagc gtgtttgaca tctttgaact caccggggcc gcccgcaagg       60

ggtctgggcg ccgactggtg aagggccccg acccttccag cccagctttc cgcatcgagg      120

atgccaacct gatcccccct gtgcctgatg acaagttcca agacctggtg gatgctgtgc      180

gggcagaaaa gggtttcctc cttctggcat ccctgaggca gatgaagaag acccggggca      240

cgctgctggc cctggagcgg aaagaccact ctggccaggt cttcagcgtg gtgtccaatg      300

gcaaggcggg caccctggac ctcagcctga ccgtccaagg aaagcagcac gtggtgtctg      360

tggaagaagc tctcctggca accggccagt ggaagagcat caccctgttt gtgcaggaag      420

acagggccca gctgtacatc gactgtgaaa agatggagaa tgctgagttg gacgtcccca      480

tccaaagcgt cttcaccaga gacctggcca gcatcgccag actccgcatc gcaaaggggg      540

gcgtcaatga caatttccag                                                  560


<210>  381
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  381
ggggtgctgc agaatgtgag gtttgtcttt ggaaccacac cagaagacat cctcaggaac       60

aaaggctgct ccagct                                                       76


<210>  382
<211>  200
<212>  DNA
<213>  Homo sapiens

<400>  382
ctaccagtgt cctcctcacc cttgacaaca acgtggtgaa tggttccagc cctgccatcc       60

gcactaacta cattggccac aagacaaagg acttgcaagc catctgcggc atctcctgtg      120

atgagctgtc cagcatggtc ctggaactca ggggcctgcg caccattgtg accacgctgc      180

aggacagcat ccgcaaagtg                                                  200


<210>  383
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  383
actgaagaga acaaagagtt ggccaatgag ctgaggcggc ctcccctatg ctatcacaac       60

ggagttcagt acagaaataa cgaggaatgg actgttgata gctgcactga gtgtcactgt      120

cag                                                                    123


<210>  384
<211>  94
<212>  DNA
<213>  Homo sapiens

<400>  384
aactcagtta ccatctgcaa aaaggtgtcc tgccccatca tgccctgctc caatgccaca       60

gttcctgatg gagaatgctg tcctcgctgt tggc                                   94


<210>  385
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  385
ccagcgactc tgcggacgat ggctggtctc catggtccga gtggacctcc tgttctacga       60

gctgtggcaa tggaattcag cagcgcggcc gctcctgcga tagcctcaac aaccgatgtg      120

agggctcctc ggtccagaca cggacctgcc acattcagga gtgtgacaag agat            174


<210>  386
<211>  177
<212>  DNA
<213>  Homo sapiens

<400>  386
ttaaacagga tggtggctgg agccactggt ccccgtggtc atcttgttct gtgacatgtg       60

gtgatggtgt gatcacaagg atccggctct gcaactctcc cagcccccag atgaacggga      120

aaccctgtga aggcgaagcg cgggagacca aagcctgcaa gaaagacgcc tgcccca         177


<210>  387
<211>  4547
<212>  DNA
<213>  Homo sapiens

<400>  387
ttaaacagga tggtggctgg agccactggt ccccgtggtc atcttgttct gtgacatgtg       60

gtgatggtgt gatcacaagg atccggctct gcaactctcc cagcccccag atgaacggga      120

aaccctgtga aggcgaagcg cgggagacca aagcctgcaa gaaagacgcc tgccccatca      180

atggaggctg gggtccttgg tcaccatggg acatctgttc tgtcacctgt ggaggagggg      240

tacagaaacg tagtcgtctc tgcaacaacc ccacacccca gtttggaggc aaggactgcg      300

ttggtgatgt aacagaaaac cagatctgca acaagcagga ctgtccaatt gatggatgcc      360

tgtccaatcc ctgctttgcc ggcgtgaagt gtactagcta ccctgatggc agctggaaat      420

gtggtgcttg tccccctggt tacagtggaa atggcatcca gtgcacagat gttgatgagt      480

gcaaagaagt gcctgatgcc tgcttcaacc acaatggaga gcaccggtgt gagaacacgg      540

accccggcta caactgcctg ccctgccccc cacgcttcac cggctcacag cccttcggcc      600

agggtgtcga acatgccacg gccaacaaac aggtgtgcaa gccccgtaac ccctgcacgg      660

atgggaccca cgactgcaac aagaacgcca agtgcaacta cctgggccac tatagcgacc      720

ccatgtaccg ctgcgagtgc aagcctggct acgctggcaa tggcatcatc tgcggggagg      780

acacagacct ggatggctgg cccaatgaga acctggtgtg cgtggccaat gcgacttacc      840

actgcaaaaa ggataattgc cccaaccttc ccaactcagg gcaggaagac tatgacaagg      900

atggaattgg tgatgcctgt gatgatgacg atgacaatga taaaattcca gatgacaggg      960

acaactgtcc attccattac aacccagctc agtatgacta tgacagagat gatgtgggag     1020

accgctgtga caactgtccc tacaaccaca acccagatca ggcagacaca gacaacaatg     1080

gggaaggaga cgcctgtgct gcagacattg atggagacgg tatcctcaat gaacgggaca     1140

actgccagta cgtctacaat gtggaccaga gagacactga tatggatggg gttggagatc     1200

agtgtgacaa ttgccccttg gaacacaatc cggatcagct ggactctgac tcagaccgca     1260

ttggagatac ctgtgacaac aatcaggata ttgatgaaga tggccaccag aacaatctgg     1320

acaactgtcc ctatgtgccc aatgccaacc aggctgacca tgacaaagat ggcaagggag     1380

atgcctgtga ccacgatgat gacaacgatg gcattcctga tgacaaggac aactgcagac     1440

tcgtgcccaa tcccgaccag aaggactctg acggcgatgg tcgaggtgat gcctgcaaag     1500

atgattttga ccatgacagt gtgccagaca tcgatgacat ctgtcctgag aatgttgaca     1560

tcagtgagac cgatttccgc cgattccaga tgattcctct ggaccccaaa gggacatccc     1620

aaaatgaccc taactgggtt gtacgccatc agggtaaaga actcgtccag actgtcaact     1680

gtgatcctgg actcgctgta ggttatgatg agtttaatgc tgtggacttc agtggcacct     1740

tcttcatcaa caccgaaagg gacgatgact atgctggatt tgtctttggc taccagtcca     1800

gcagccgctt ttatgttgtg atgtggaagc aagtcaccca gtcctactgg gacaccaacc     1860

ccacgagggc tcagggatac tcgggccttt ctgtgaaagt tgtaaactcc accacagggc     1920

ctggcgagca cctgcggaac gccctgtggc acacaggaaa cacccctggc caggtgcgca     1980

ccctgtggca tgaccctcgt cacataggct ggaaagattt caccgcctac agatggcgtc     2040

tcagccacag gccaaagacg ggtttcatta gagtggtgat gtatgaaggg aagaaaatca     2100

tggctgactc aggacccatc tatgataaaa cctatgctgg tggtagacta gggttgtttg     2160

tcttctctca agaaatggtg ttcttctctg acctgaaata cgaatgtaga gatccctaat     2220

catcaaattg ttgattgaaa gactgatcat aaaccaatgc tggtattgca ccttctggaa     2280

ctatgggctt gagaaaaccc ccaggatcac ttctccttgg cttccttctt ttctgtgctt     2340

gcatcagtgt ggactcctag aacgtgcgac ctgcctcaag aaaatgcagt tttcaaaaac     2400

agactcagca ttcagcctcc aatgaataag acatcttcca agcatataaa caattgcttt     2460

ggtttccttt tgaaaaagca tctacttgct tcagttggga aggtgcccat tccactctgc     2520

ctttgtcaca gagcagggtg ctattgtgag gccatctctg agcagtggac tcaaaagcat     2580

tttcaggcat gtcagagaag ggaggactca ctagaattag caaacaaaac caccctgaca     2640

tcctccttca ggaacacggg gagcagaggc caaagcacta aggggagggc gcatacccga     2700

gacgattgta tgaagaaaat atggaggaac tgttacatgt tcggtactaa gtcattttca     2760

ggggattgaa agactattgc tggatttcat gatgctgact ggcgttagct gattaaccca     2820

tgtaaatagg cacttaaata gaagcaggaa agggagacaa agactggctt ctggacttcc     2880

tccctgatcc ccacccttac tcatcacctg cagtggccag aattagggaa tcagaatcaa     2940

accagtgtaa ggcagtgctg gctgccattg cctggtcaca ttgaaattgg tggcttcatt     3000

ctagatgtag cttgtgcaga tgtagcagga aaataggaaa acctaccatc tcagtgagca     3060

ccagctgcct cccaaaggag gggcagccgt gcttatattt ttatggttac aatggcacaa     3120

aattattatc aacctaacta aaacattcct tttctctttt ttcctgaatt atcatggagt     3180

tttctaattc tctcttttgg aatgtagatt ttttttaaat gctttacgat gtaaaatatt     3240

tattttttac ttattctgga agatctggct gaaggattat tcatggaaca ggaagaagcg     3300

taaagactat ccatgtcatc tttgttgaga gtcttcgtga ctgtaagatt gtaaatacag     3360

attatttatt aactctgttc tgcctggaaa tttaggcttc atacggaaag tgtttgagag     3420

caagtagttg acatttatca gcaaatctct tgcaagaaca gcacaaggaa aatcagtcta     3480

ataagctgct ctgccccttg tgctcagagt ggatgttatg ggattctttt tttctctgtt     3540

ttatcttttc aagtggaatt agttggttat ccatttgcaa atgttttaaa ttgcaaagaa     3600

agccatgagg tcttcaatac tgttttaccc catcccttgt gcatatttcc agggagaagg     3660

aaagcatata cacttttttc tttcattttt ccaaaagaga aaaaaatgac aaaaggtgaa     3720

acttacatac aaatattacc tcatttgttg tgtgactgag taaagaattt ttggatcaag     3780

cggaaagagt ttaagtgtct aacaaactta aagctactgt agtacctaaa aagtcagtgt     3840

tgtacatagc ataaaaactc tgcagagaag tattcccaat aaggaaatag cattgaaatg     3900

ttaaatacaa tttctgaaag ttatgttttt tttctatcat ctggtatacc attgctttat     3960

ttttataaat tattttctca ttgccattgg aatagatatc tcagattgtg tagatatgct     4020

atttaaataa tttatcagga aatactgcct gtagagttag tatttctatt tttatataat     4080

gtttgcacac tgaattgaag aattgttggt tttttctttt ttttgttttg tttttttttt     4140

tttttttttt tgcttttgac ctcccatttt tactatttgc caataccttt ttctaggaat     4200

gtgctttttt ttgtacacat ttttatccat tttacattct aaagcagtgt aagttgtata     4260

ttactgtttc ttatgtacaa ggaacaacaa taaatcatat ggaaatttat atttatactt     4320

actgtatcca tgcttatttg ttctctactg gctttatgtc atgaagtata tgcgtaaata     4380

ccattcataa atcaatatag catatacaaa aataaattac agtaagtcat agcaacattc     4440

acagtttgta tgtgattgag aaagactgag ttgctcaggc ctaggcttag aatttgctgc     4500

gtttgtggaa taaaagaaca aaatgataca ttagcctgcc atatcaa                   4547


<210>  388
<211>  6197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of THBS1

<400>  388
agccgctgcg cccgagctgg cctgcgagtt cagggctcct gtcgctctcc aggagcaacc       60

tctactccgg acgcacaggc attccccgcg cccctccagc cctcgccgcc ctcgccaccg      120

ctcccggccg ccgcgctccg gtacacacag gatccctgct gggcaccaac agctccacca      180

tggggctggc ctggggacta ggcgtcctgt tcctgatgca tgtgtgtggc accaaccgca      240

ttccagagtc tggcggagac aacagcgtgt ttgacatctt tgaactcacc ggggccgccc      300

gcaaggggtc tgggcgccga ctggtgaagg gccccgaccc ttccagccca gctttccgca      360

tcgaggatgc caacctgatc ccccctgtgc ctgatgacaa gttccaagac ctggtggatg      420

ctgtgcgggc agaaaagggt ttcctccttc tggcatccct gaggcagatg aagaagaccc      480

ggggcacgct gctggccctg gagcggaaag accactctgg ccaggtcttc agcgtggtgt      540

ccaatggcaa ggcgggcacc ctggacctca gcctgaccgt ccaaggaaag cagcacgtgg      600

tgtctgtgga agaagctctc ctggcaaccg gccagtggaa gagcatcacc ctgtttgtgc      660

aggaagacag ggcccagctg tacatcgact gtgaaaagat ggagaatgct gagttggacg      720

tccccatcca aagcgtcttc accagagacc tggccagcat cgccagactc cgcatcgcaa      780

aggggggcgt caatgacaat ttccaggggg tgctgcagaa tgtgaggttt gtctttggaa      840

ccacaccaga agacatcctc aggaacaaag gctgctccag ctctaccagt gtcctcctca      900

cccttgacaa caacgtggtg aatggttcca gccctgccat ccgcactaac tacattggcc      960

acaagacaaa ggacttgcaa gccatctgcg gcatctcctg tgatgagctg tccagcatgg     1020

tcctggaact caggggcctg cgcaccattg tgaccacgct gcaggacagc atccgcaaag     1080

tgactgaaga gaacaaagag ttggccaatg agctgaggcg gcctccccta tgctatcaca     1140

acggagttca gtacagaaat aacgaggaat ggactgttga tagctgcact gagtgtcact     1200

gtcagaactc agttaccatc tgcaaaaagg tgtcctgccc catcatgccc tgctccaatg     1260

ccacagttcc tgatggagaa tgctgtcctc gctgttggcc cagcgactct gcggacgatg     1320

gctggtctcc atggtccgag tggacctcct gttctacgag ctgtggcaat ggaattcagc     1380

agcgcggccg ctcctgcgat agcctcaaca accgatgtga gggctcctcg gtccagacac     1440

ggacctgcca cattcaggag tgtgacaaga gatttaaaca ggatggtggc tggagccact     1500

ggtccccgtg gtcatcttgt tctgtgacat gtggtgatgg tgtgatcaca aggatccggc     1560

tctgcaactc tcccagcccc cagatgaacg ggaaaccctg tgaaggcgaa gcgcgggaga     1620

ccaaagcctg caagaaagac gcctgcccca ttaaacagga tggtggctgg agccactggt     1680

ccccgtggtc atcttgttct gtgacatgtg gtgatggtgt gatcacaagg atccggctct     1740

gcaactctcc cagcccccag atgaacggga aaccctgtga aggcgaagcg cgggagacca     1800

aagcctgcaa gaaagacgcc tgccccatca atggaggctg gggtccttgg tcaccatggg     1860

acatctgttc tgtcacctgt ggaggagggg tacagaaacg tagtcgtctc tgcaacaacc     1920

ccacacccca gtttggaggc aaggactgcg ttggtgatgt aacagaaaac cagatctgca     1980

acaagcagga ctgtccaatt gatggatgcc tgtccaatcc ctgctttgcc ggcgtgaagt     2040

gtactagcta ccctgatggc agctggaaat gtggtgcttg tccccctggt tacagtggaa     2100

atggcatcca gtgcacagat gttgatgagt gcaaagaagt gcctgatgcc tgcttcaacc     2160

acaatggaga gcaccggtgt gagaacacgg accccggcta caactgcctg ccctgccccc     2220

cacgcttcac cggctcacag cccttcggcc agggtgtcga acatgccacg gccaacaaac     2280

aggtgtgcaa gccccgtaac ccctgcacgg atgggaccca cgactgcaac aagaacgcca     2340

agtgcaacta cctgggccac tatagcgacc ccatgtaccg ctgcgagtgc aagcctggct     2400

acgctggcaa tggcatcatc tgcggggagg acacagacct ggatggctgg cccaatgaga     2460

acctggtgtg cgtggccaat gcgacttacc actgcaaaaa ggataattgc cccaaccttc     2520

ccaactcagg gcaggaagac tatgacaagg atggaattgg tgatgcctgt gatgatgacg     2580

atgacaatga taaaattcca gatgacaggg acaactgtcc attccattac aacccagctc     2640

agtatgacta tgacagagat gatgtgggag accgctgtga caactgtccc tacaaccaca     2700

acccagatca ggcagacaca gacaacaatg gggaaggaga cgcctgtgct gcagacattg     2760

atggagacgg tatcctcaat gaacgggaca actgccagta cgtctacaat gtggaccaga     2820

gagacactga tatggatggg gttggagatc agtgtgacaa ttgccccttg gaacacaatc     2880

cggatcagct ggactctgac tcagaccgca ttggagatac ctgtgacaac aatcaggata     2940

ttgatgaaga tggccaccag aacaatctgg acaactgtcc ctatgtgccc aatgccaacc     3000

aggctgacca tgacaaagat ggcaagggag atgcctgtga ccacgatgat gacaacgatg     3060

gcattcctga tgacaaggac aactgcagac tcgtgcccaa tcccgaccag aaggactctg     3120

acggcgatgg tcgaggtgat gcctgcaaag atgattttga ccatgacagt gtgccagaca     3180

tcgatgacat ctgtcctgag aatgttgaca tcagtgagac cgatttccgc cgattccaga     3240

tgattcctct ggaccccaaa gggacatccc aaaatgaccc taactgggtt gtacgccatc     3300

agggtaaaga actcgtccag actgtcaact gtgatcctgg actcgctgta ggttatgatg     3360

agtttaatgc tgtggacttc agtggcacct tcttcatcaa caccgaaagg gacgatgact     3420

atgctggatt tgtctttggc taccagtcca gcagccgctt ttatgttgtg atgtggaagc     3480

aagtcaccca gtcctactgg gacaccaacc ccacgagggc tcagggatac tcgggccttt     3540

ctgtgaaagt tgtaaactcc accacagggc ctggcgagca cctgcggaac gccctgtggc     3600

acacaggaaa cacccctggc caggtgcgca ccctgtggca tgaccctcgt cacataggct     3660

ggaaagattt caccgcctac agatggcgtc tcagccacag gccaaagacg ggtttcatta     3720

gagtggtgat gtatgaaggg aagaaaatca tggctgactc aggacccatc tatgataaaa     3780

cctatgctgg tggtagacta gggttgtttg tcttctctca agaaatggtg ttcttctctg     3840

acctgaaata cgaatgtaga gatccctaat catcaaattg ttgattgaaa gactgatcat     3900

aaaccaatgc tggtattgca ccttctggaa ctatgggctt gagaaaaccc ccaggatcac     3960

ttctccttgg cttccttctt ttctgtgctt gcatcagtgt ggactcctag aacgtgcgac     4020

ctgcctcaag aaaatgcagt tttcaaaaac agactcagca ttcagcctcc aatgaataag     4080

acatcttcca agcatataaa caattgcttt ggtttccttt tgaaaaagca tctacttgct     4140

tcagttggga aggtgcccat tccactctgc ctttgtcaca gagcagggtg ctattgtgag     4200

gccatctctg agcagtggac tcaaaagcat tttcaggcat gtcagagaag ggaggactca     4260

ctagaattag caaacaaaac caccctgaca tcctccttca ggaacacggg gagcagaggc     4320

caaagcacta aggggagggc gcatacccga gacgattgta tgaagaaaat atggaggaac     4380

tgttacatgt tcggtactaa gtcattttca ggggattgaa agactattgc tggatttcat     4440

gatgctgact ggcgttagct gattaaccca tgtaaatagg cacttaaata gaagcaggaa     4500

agggagacaa agactggctt ctggacttcc tccctgatcc ccacccttac tcatcacctg     4560

cagtggccag aattagggaa tcagaatcaa accagtgtaa ggcagtgctg gctgccattg     4620

cctggtcaca ttgaaattgg tggcttcatt ctagatgtag cttgtgcaga tgtagcagga     4680

aaataggaaa acctaccatc tcagtgagca ccagctgcct cccaaaggag gggcagccgt     4740

gcttatattt ttatggttac aatggcacaa aattattatc aacctaacta aaacattcct     4800

tttctctttt ttcctgaatt atcatggagt tttctaattc tctcttttgg aatgtagatt     4860

ttttttaaat gctttacgat gtaaaatatt tattttttac ttattctgga agatctggct     4920

gaaggattat tcatggaaca ggaagaagcg taaagactat ccatgtcatc tttgttgaga     4980

gtcttcgtga ctgtaagatt gtaaatacag attatttatt aactctgttc tgcctggaaa     5040

tttaggcttc atacggaaag tgtttgagag caagtagttg acatttatca gcaaatctct     5100

tgcaagaaca gcacaaggaa aatcagtcta ataagctgct ctgccccttg tgctcagagt     5160

ggatgttatg ggattctttt tttctctgtt ttatcttttc aagtggaatt agttggttat     5220

ccatttgcaa atgttttaaa ttgcaaagaa agccatgagg tcttcaatac tgttttaccc     5280

catcccttgt gcatatttcc agggagaagg aaagcatata cacttttttc tttcattttt     5340

ccaaaagaga aaaaaatgac aaaaggtgaa acttacatac aaatattacc tcatttgttg     5400

tgtgactgag taaagaattt ttggatcaag cggaaagagt ttaagtgtct aacaaactta     5460

aagctactgt agtacctaaa aagtcagtgt tgtacatagc ataaaaactc tgcagagaag     5520

tattcccaat aaggaaatag cattgaaatg ttaaatacaa tttctgaaag ttatgttttt     5580

tttctatcat ctggtatacc attgctttat ttttataaat tattttctca ttgccattgg     5640

aatagatatc tcagattgtg tagatatgct atttaaataa tttatcagga aatactgcct     5700

gtagagttag tatttctatt tttatataat gtttgcacac tgaattgaag aattgttggt     5760

tttttctttt ttttgttttg tttttttttt tttttttttt tgcttttgac ctcccatttt     5820

tactatttgc caataccttt ttctaggaat gtgctttttt ttgtacacat ttttatccat     5880

tttacattct aaagcagtgt aagttgtata ttactgtttc ttatgtacaa ggaacaacaa     5940

taaatcatat ggaaatttat atttatactt actgtatcca tgcttatttg ttctctactg     6000

gctttatgtc atgaagtata tgcgtaaata ccattcataa atcaatatag catatacaaa     6060

aataaattac agtaagtcat agcaacattc acagtttgta tgtgattgag aaagactgag     6120

ttgctcaggc ctaggcttag aatttgctgc gtttgtggaa taaaagaaca aaatgataca     6180

ttagcctgcc atatcaa                                                    6197


<210>  389
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro 
            20          


<210>  390
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  390

Ser Gly Gly Asp Asn Ser Val Phe Asp Ile Phe Glu Leu Thr Gly Ala 
1               5                   10                  15      


Ala Arg Lys Gly Ser Gly Arg Arg Leu Val Lys Gly Pro Asp Pro Ser 
            20                  25                  30          


Ser Pro Ala Phe Arg Ile Glu Asp Ala Asn Leu Ile Pro Pro Val Pro 
        35                  40                  45              


Asp Asp Lys Phe Gln Asp Leu Val Asp Ala Val Arg Ala Glu Lys Gly 
    50                  55                  60                  


Phe Leu Leu Leu Ala Ser Leu Arg Gln Met Lys Lys Thr Arg Gly Thr 
65                  70                  75                  80  


Leu Leu Ala Leu Glu Arg Lys Asp His Ser Gly Gln Val Phe Ser Val 
                85                  90                  95      


Val Ser Asn Gly Lys Ala Gly Thr Leu Asp Leu Ser Leu Thr Val Gln 
            100                 105                 110         


Gly Lys Gln His Val Val Ser Val Glu Glu Ala Leu Leu Ala Thr Gly 
        115                 120                 125             


Gln Trp Lys Ser Ile Thr Leu Phe Val Gln Glu Asp Arg Ala Gln Leu 
    130                 135                 140                 


Tyr Ile Asp Cys Glu Lys Met Glu Asn Ala Glu Leu Asp Val Pro Ile 
145                 150                 155                 160 


Gln Ser Val Phe Thr Arg Asp Leu Ala Ser Ile Ala Arg Leu Arg Ile 
                165                 170                 175     


Ala Lys Gly Gly Val Asn Asp Asn Phe Gln 
            180                 185     


<210>  391
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  391

Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu Asp 
1               5                   10                  15      


Ile Leu Arg Asn Lys Gly Cys Ser Ser 
            20                  25  


<210>  392
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  392

Thr Ser Val Leu Leu Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser 
1               5                   10                  15      


Pro Ala Ile Arg Thr Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln 
            20                  25                  30          


Ala Ile Cys Gly Ile Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu 
        35                  40                  45              


Leu Arg Gly Leu Arg Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg 
    50                  55                  60                  


Lys Val 
65      


<210>  393
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  393

Thr Glu Glu Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu 
1               5                   10                  15      


Cys Tyr His Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val 
            20                  25                  30          


Asp Ser Cys Thr Glu Cys His Cys Gln 
        35                  40      


<210>  394
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  394

Asn Ser Val Thr Ile Cys Lys Lys Val Ser Cys Pro Ile Met Pro Cys 
1               5                   10                  15      


Ser Asn Ala Thr Val Pro Asp Gly Glu Cys Cys Pro Arg Cys Trp 
            20                  25                  30      


<210>  395
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  395

Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro Trp Ser Glu Trp Thr Ser 
1               5                   10                  15      


Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln Gln Arg Gly Arg Ser Cys 
            20                  25                  30          


Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser Ser Val Gln Thr Arg Thr 
        35                  40                  45              


Cys His Ile Gln Glu Cys Asp Lys Arg 
    50                  55          


<210>  396
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  396

Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
1               5                   10                  15      


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
            20                  25                  30          


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
        35                  40                  45              


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro 
    50                  55              


<210>  397
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  397

Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
1               5                   10                  15      


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
            20                  25                  30          


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
        35                  40                  45              


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
    50                  55                  60                  


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
65                  70                  75                  80  


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
                85                  90                  95      


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
            100                 105                 110         


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
        115                 120                 125             


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
    130                 135                 140                 


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
145                 150                 155                 160 


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
                165                 170                 175     


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
            180                 185                 190         


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
        195                 200                 205             


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
    210                 215                 220                 


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
225                 230                 235                 240 


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
                245                 250                 255     


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
            260                 265                 270         


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
        275                 280                 285             


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
    290                 295                 300                 


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
305                 310                 315                 320 


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
                325                 330                 335     


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
            340                 345                 350         


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
        355                 360                 365             


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
    370                 375                 380                 


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
385                 390                 395                 400 


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
                405                 410                 415     


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
            420                 425                 430         


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
        435                 440                 445             


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
    450                 455                 460                 


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
465                 470                 475                 480 


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
                485                 490                 495     


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
            500                 505                 510         


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
        515                 520                 525             


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
    530                 535                 540                 


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
545                 550                 555                 560 


Asp Pro Gly Leu Ala Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe 
                565                 570                 575     


Ser Gly Thr Phe Phe Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly 
            580                 585                 590         


Phe Val Phe Gly Tyr Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp 
        595                 600                 605             


Lys Gln Val Thr Gln Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln 
    610                 615                 620                 


Gly Tyr Ser Gly Leu Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro 
625                 630                 635                 640 


Gly Glu His Leu Arg Asn Ala Leu Trp His Thr Gly Asn Thr Pro Gly 
                645                 650                 655     


Gln Val Arg Thr Leu Trp His Asp Pro Arg His Ile Gly Trp Lys Asp 
            660                 665                 670         


Phe Thr Ala Tyr Arg Trp Arg Leu Ser His Arg Pro Lys Thr Gly Phe 
        675                 680                 685             


Ile Arg Val Val Met Tyr Glu Gly Lys Lys Ile Met Ala Asp Ser Gly 
    690                 695                 700                 


Pro Ile Tyr Asp Lys Thr Tyr Ala Gly Gly Arg Leu Gly Leu Phe Val 
705                 710                 715                 720 


Phe Ser Gln Glu Met Val Phe Phe Ser Asp Leu Lys Tyr Glu Cys Arg 
                725                 730                 735     


Asp Pro 
        


<210>  398
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  399
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400>  399
agccgctgcg cccgagctgg cctgcgagtt cagggctcct gtcgctctcc aggagcaacc       60

tctactccgg acgcacaggc attccccgcg cccctccagc cctcgccgcc ctcgccaccg      120

ctcccggccg ccgcgctccg gtacacacag gatccctgct gggcaccaac agctccacca      180

tggggctggc ctggggacta ggcgtcctgt tcctgatgca tgtgtgtggc accaaccgca      240

ttccagagtc tggcggagac aacagcgtgt ttgacatctt tgaactcacc ggggccgccc      300

gcaaggggtc tgggcgccga ctggtgaagg gccccgaccc ttccagccca gctttccgca      360

tcgaggatgc caacctgatc ccccctgtgc ctgatgacaa gttccaagac ctggtggatg      420

ctgtgcgggc agaaaagggt ttcctccttc tggcatccct gaggcagatg aagaagaccc      480

ggggcacgct gctggccctg gagcggaaag accactctgg ccaggtcttc agcgtggtgt      540

ccaatggcaa ggcgggcacc ctggacctca gcctgaccgt ccaaggaaag cagcacgtgg      600

tgtctgtgga agaagctctc ctggcaaccg gccagtggaa gagcatcacc ctgtttgtgc      660

aggaagacag ggcccagctg tacatcgact gtgaaaagat ggagaatgct gagttggacg      720

tccccatcca aagcgtcttc accagagacc tggccagcat cgccagactc cgcatcgcaa      780

aggggggcgt caatgacaat ttccaggggg tgctgcagaa tgtgaggttt gtctttggaa      840

ccacaccaga agacatcctc aggaacaaag gctgctccag ctctaccagt gtcctcctca      900

cccttgacaa caacgtggtg aatggttcca gccctgccat ccgcactaac tacattggcc      960

acaagacaaa ggacttgcaa gccatctgcg gcatctcctg tgatgagctg tccagcatgg     1020

tcctggaact caggggcctg cgcaccattg tgaccacgct gcaggacagc atccgcaaag     1080

tgactgaaga gaacaaagag ttggccaatg agctgaggcg gcctccccta tgctatcaca     1140

acggagttca gtacagaaat aacgaggaat ggactgttga tagctgcact gagtgtcact     1200

gtcagaactc agttaccatc tgcaaaaagg tgtcctgccc catcatgccc tgctccaatg     1260

ccacagttcc tgatggagaa tgctgtcctc gctgttggcc cagcgactct gcggacgatg     1320

gctggtctcc atggtccgag tggacctcct gttctacgag ctgtggcaat ggaattcagc     1380

agcgcggccg ctcctgcgat agcctcaaca accgatgtga gggctcctcg gtccagacac     1440

ggacctgcca cattcaggag tgtgacaaga gatttaaaca ggatggtggc tggagccact     1500

ggtccccgtg gtcatcttgt tctgtgacat gtggtgatgg tgtgatcaca aggatccggc     1560

tctgcaactc tcccagcccc cagatgaacg ggaaaccctg tgaaggcgaa gcgcgggaga     1620

ccaaagcctg caagaaagac gcctgcccca                                      1650


<210>  400
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro 
                485                 490 


<210>  401
<211>  106
<212>  DNA
<213>  Homo sapiens

<400>  401
gtgtgcggct cagatggggt cacctacagc accgagtgtg agctgaagaa ggccaggtgt       60

gagtcacagc gagggctcta cgtagcggcc cagggagcct gccgag                     106


<210>  402
<211>  101
<212>  DNA
<213>  Homo sapiens

<400>  402
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgcttca tggtgaaaga c                          101


<210>  403
<211>  207
<212>  DNA
<213>  Homo sapiens

<400>  403
gtgtgcggct cagatggggt cacctacagc accgagtgtg agctgaagaa ggccaggtgt       60

gagtcacagc gagggctcta cgtagcggcc cagggagcct gccgagctac atctacatcc      120

accactggga caagccatct tgtaaaatgt gcggagaagg agaaaacttt ctgtgtgaat      180

ggaggggagt gcttcatggt gaaagac                                          207


<210>  404
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  404

Val Cys Gly Ser Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys 
1               5                   10                  15      


Lys Ala Arg Cys Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly 
            20                  25                  30          


Ala Cys Arg Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val 
        35                  40                  45              


Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys 
    50                  55                  60                  


Phe Met Val Lys Asp 
65                  


<210>  405
<211>  254
<212>  DNA
<213>  Homo sapiens

<400>  405
agtcccgtcc ccggcgcggc ccgcgcgctc ctccgccgcc tctcgcctgc gccatggccg       60

gccggtccca cccgggcccg ctgcggccgc tgctgccgct ccttgtggtg gccgcgtgcg      120

tcctgcccgg agccggcggg acatgcccgg agcgcgcgct ggagcggcgc gaggaggagg      180

cgaacgtggt gctcaccggg acggtggagg agatcctcaa cgtggacccg gtgcagcaca      240

cgtactcctg caag                                                        254


<210>  406
<211>  262
<212>  DNA
<213>  Homo sapiens

<400>  406
gttcgggtct ggcggtactt gaagggcaaa gacctggtgg cccgggagag cctgctggac       60

ggcggcaaca aggtggtgat cagcggcttt ggagaccccc tcatctgtga caaccaggtg      120

tccactgggg acaccaggat cttctttgtg aaccctgcac ccccatacct gtggccagcc      180

cacaagaacg agctgatgct caactccagc ctcatgcgga tcaccctgcg gaacctggag      240

gaggtggagt tctgtgtgga ag                                               262


<210>  407
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  407
ataaacccgg gacccacttc actccagtgc ctccgacgcc tcctgatg                    48


<210>  408
<211>  216
<212>  DNA
<213>  Homo sapiens

<400>  408
cgtgccgggg aatgctgtgc ggcttcggcg ccgtgtgcga gcccaacgcg gaggggccgg       60

gccgggcgtc ctgcgtctgc aagaagagcc cgtgccccag cgtggtggcg cctgtgtgtg      120

ggtcggacgc ctccacctac agcaacgaat gcgagctgca gcgggcgcag tgcagccagc      180

agcgccgcat ccgcctgctc agccgcgggc cgtgcg                                216


<210>  409
<211>  225
<212>  DNA
<213>  Homo sapiens

<400>  409
gctcgcggga cccctgctcc aacgtgacct gcagcttcgg cagcacctgt gcgcgctcgg       60

ccgacgggct gacggcctcg tgcctgtgcc ccgcgacctg ccgtggcgcc cccgagggga      120

ccgtctgcgg cagcgacggc gccgactacc ccggcgagtg ccagctcctg cgccgcgcct      180

gcgcccgcca ggagaatgtc ttcaagaagt tcgacggccc ttgtg                      225


<210>  410
<211>  225
<212>  DNA
<213>  Homo sapiens

<400>  410
acccctgtca gggcgccctc cctgacccga gccgcagctg ccgtgtgaac ccgcgcacgc       60

ggcgccctga gatgctccta cggcccgaga gctgccctgc ccggcaggcg ccagtgtgtg      120

gggacgacgg agtcacctac gaaaacgact gtgtcatggg ccgatcgggg gccgcccggg      180

gtctcctcct gcagaaagtg cgctccggcc agtgccaggg tcgag                      225


<210>  411
<211>  207
<212>  DNA
<213>  Homo sapiens

<400>  411
accagtgccc ggagccctgc cggttcaatg ccgtgtgcct gtcccgccgt ggccgtcccc       60

gctgctcctg cgaccgcgtc acctgtgacg gggcctacag gcccgtgtgt gcccaggacg      120

ggcgcacgta tgacagtgat tgctggcggc agcaggctga gtgccggcag cagcgtgcca      180

tccccagcaa gcaccagggc ccgtgtg                                          207


<210>  412
<211>  219
<212>  DNA
<213>  Homo sapiens

<400>  412
accaggcccc gtccccatgc ctcggggtgc agtgtgcatt tggggcgacg tgtgctgtga       60

agaacgggca ggcagcgtgt gaatgcctgc aggcgtgctc gagcctctac gatcctgtgt      120

gcggcagcga cggcgtcaca tacggcagcg cgtgcgagct ggaggccacg gcctgtaccc      180

tcgggcggga gatccaggtg gcgcgcaaag gaccctgtg                             219


<210>  413
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  413
accgctgcgg gcagtgccgc tttggagccc tgtgcgaggc cgagaccggg cgctgcgtgt       60

gcccctctga atgcgtggct ttggcccagc ccgtgtgtgg ctccgacggg cacacgtacc      120

ccagcgagtg catgctgcac gtgcacgcct gcacacacca gatcagcctg cacgtggcct      180

cagctggacc ctgtg                                                       195


<210>  414
<211>  201
<212>  DNA
<213>  Homo sapiens

<400>  414
agacctgtgg agatgccgtg tgtgcttttg gggctgtgtg ctccgcaggg cagtgtgtgt       60

gtccccggtg tgagcacccc ccgcccggcc ccgtgtgtgg cagcgacggt gtcacctacg      120

gcagtgcctg cgagctacgg gaagccgcct gcctccagca gacacagatc gaggaggccc      180

gggcagggcc gtgcgagcag g                                                201


<210>  415
<211>  149
<212>  DNA
<213>  Homo sapiens

<400>  415
ccgagtgcgg ttccggaggc tctggctctg gggaggacgg tgactgtgag caggagctgt       60

gccggcagcg cggtggcatc tgggacgagg actcggagga cgggccgtgt gtctgtgact      120

tcagctgcca gagtgtccca ggcagcccg                                        149


<210>  416
<211>  106
<212>  DNA
<213>  Homo sapiens

<400>  416
gtgtgcggct cagatggggt cacctacagc accgagtgtg agctgaagaa ggccaggtgt       60

gagtcacagc gagggctcta cgtagcggcc cagggagcct gccgag                     106


<210>  417
<211>  5088
<212>  DNA
<213>  Homo sapiens

<400>  417
gccccacctt cgccccgctg ccgcctgtgg cccccttaca ctgtgcccag acgccctacg       60

gctgctgcca ggacaatatc accgcagccc ggggcgtggg cctggctggc tgccccagtg      120

cctgccagtg caacccccat ggctcttacg gcggcacctg tgacccagcc acaggccagt      180

gctcctgccg cccaggtgtg gggggcctca ggtgtgaccg ctgtgagcct ggcttctgga      240

actttcgagg catcgtcacc gatggccgga gtggctgtac accctgcagc tgtgatcccc      300

aaggcgccgt gcgggatgac tgtgagcaga tgacggggct gtgctcgtgt aagcccgggg      360

tggctggacc caagtgtggg cagtgtccag acggccgtgc cctgggcccc gcgggctgtg      420

aagctgacgc ttctgcgcct gcgacctgtg cggagatgcg ctgtgagttc ggtgcgcggt      480

gcgtggagga gtctggctca gcccactgtg tctgcccgat gctcacctgt ccagaggcca      540

acgctaccaa ggtctgtggg tcagatggag tcacatacgg caacgagtgt cagctgaaga      600

ccatcgcctg ccgccagggc ctgcaaatct ctatccagag cctgggcccg tgccaggagg      660

ctgttgctcc cagcactcac ccgacatctg cctccgtgac tgtgaccacc ccagggctcc      720

tcctgagcca ggcactgccg gccccccccg gcgccctccc cctggctccc agcagtaccg      780

cacacagcca gaccacccct ccgccctcat cacgacctcg gaccactgcc agcgtcccca      840

ggaccaccgt gtggcccgtg ctgacggtgc cccccacggc accctcccct gcacccagcc      900

tggtggcgtc cgcctttggt gaatctggca gcactgatgg aagcagcgat gaggaactga      960

gcggggacca ggaggccagt gggggtggct ctggggggct cgagcccttg gagggcagca     1020

gcgtggccac ccctgggcca cctgtcgaga gggcttcctg ctacaactcc gcgttgggct     1080

gctgctctga tgggaagacg ccctcgctgg acgcagaggg ctccaactgc cccgccacca     1140

aggtgttcca gggcgtcctg gagctggagg gcgtcgaggg ccaggagctg ttctacacgc     1200

ccgagatggc tgaccccaag tcagaactgt tcggggagac agccaggagc attgagagca     1260

ccctggacga cctcttccgg aattcagacg tcaagaagga ttttcggagt gtccgcttgc     1320

gggacctggg gcccggcaaa tccgtccgcg ccattgtgga tgtgcacttt gaccccacca     1380

cagccttcag ggcacccgac gtggcccggg ccctgctccg gcagatccag gtgtccaggc     1440

gccggtcctt gggggtgagg cggccgctgc aggagcacgt gcgatttatg gactttgact     1500

ggtttcctgc gtttatcacg ggggccacgt caggagccat tgctgcggga gccacggcca     1560

gagccaccac tgcatcgcgc ctgccgtcct ctgctgtgac ccctcgggcc ccgcacccca     1620

gtcacacaag ccagcccgtt gccaagacca cggcagcccc caccacacgt cggcccccca     1680

ccactgcccc cagccgtgtg cccggacgtc ggcccccggc cccccagcag cctccaaagc     1740

cctgtgactc acagccctgc ttccacgggg ggacctgcca ggactgggca ttgggcgggg     1800

gcttcacctg cagctgcccg gcaggcaggg gaggcgccgt ctgtgagaag gtgcttggcg     1860

cccctgtgcc ggccttcgag ggccgctcct tcctggcctt ccccactctc cgcgcctacc     1920

acacgctgcg cctggcactg gaattccggg cgctggagcc tcaggggctg ctgctgtaca     1980

atggcaacgc ccggggcaag gacttcctgg cattggcgct gctagatggc cgcgtgcagc     2040

tcaggtttga cacaggttcg gggccggcgg tgctgaccag tgccgtgccg gtagagccgg     2100

gccagtggca ccgcctggag ctgtcccggc actggcgccg gggcaccctc tcggtggatg     2160

gtgagacccc tgttctgggc gagagtccca gtggcaccga cggcctcaac ctggacacag     2220

acctctttgt gggcggcgta cccgaggacc aggctgccgt ggcgctggag cggaccttcg     2280

tgggcgccgg cctgaggggg tgcatccgtt tgctggacgt caacaaccag cgcctggagc     2340

ttggcattgg gccgggggct gccacccgag gctctggcgt gggcgagtgc ggggaccacc     2400

cctgcctgcc caacccctgc catggcgggg ccccatgcca gaacctggag gctggaaggt     2460

tccattgcca gtgcccgccc ggccgcgtcg gaccaacctg tgccgatgag aagagcccct     2520

gccagcccaa cccctgccat ggggcggcgc cctgccgtgt gctgcccgag ggtggtgctc     2580

agtgcgagtg ccccctgggg cgtgagggca ccttctgcca gacagcctcg gggcaggacg     2640

gctctgggcc cttcctggct gacttcaacg gcttctccca cctggagctg agaggcctgc     2700

acacctttgc acgggacctg ggggagaaga tggcgctgga ggtcgtgttc ctggcacgag     2760

gccccagcgg cctcctgctc tacaacgggc agaagacgga cggcaagggg gacttcgtgt     2820

cgctggcact gcgggaccgc cgcctggagt tccgctacga cctgggcaag ggggcagcgg     2880

tcatcaggag cagggagcca gtcaccctgg gagcctggac cagggtctca ctggagcgaa     2940

acggccgcaa gggtgccctg cgtgtgggcg acggcccccg tgtgttgggg gagtccccga     3000

aatcccgcaa ggttccgcac accgtcctca acctgaagga gccgctctac gtagggggcg     3060

ctcccgactt cagcaagctg gcccgtgctg ctgccgtgtc ctctggcttc gacggtgcca     3120

tccagctggt ctccctcgga ggccgccagc tgctgacccc ggagcacgtg ctgcggcagg     3180

tggacgtcac gtcctttgca ggtcacccct gcacccgggc ctcaggccac ccctgcctca     3240

atggggcctc ctgcgtcccg agggaggctg cctatgtgtg cctgtgtccc gggggattct     3300

caggaccgca ctgcgagaag gggctggtgg agaagtcagc gggggacgtg gataccttgg     3360

cctttgacgg gcggaccttt gtcgagtacc tcaacgctgt gaccgagagc gaactggcca     3420

atgagatccc cgtccccgaa actctggatt ccggggccct tcacagcgag aaggcactgc     3480

agagcaacca ctttgaactg agcctgcgca ctgaggccac gcaggggctg gtgctctgga     3540

gtggcaaggc cacggagcgg gcagactatg tggcactggc cattgtggac gggcacctgc     3600

aactgagcta caacctgggc tcccagcccg tggtgctgcg ttccaccgtg cccgtcaaca     3660

ccaaccgctg gttgcgggtc gtggcacata gggagcagag ggaaggttcc ctgcaggtgg     3720

gcaatgaggc ccctgtgacc ggctcctccc cgctgggcgc cacgcagctg gacactgatg     3780

gagccctgtg gcttgggggc ctgccggagc tgcccgtggg cccagcactg cccaaggcct     3840

acggcacagg ctttgtgggc tgcttgcggg acgtggtggt gggccggcac ccgctgcacc     3900

tgctggagga cgccgtcacc aagccagagc tgcggccctg ccccacccca tgagctggca     3960

ccagagcccc gcgcccgctg taattatttt ctatttttgt aaacttgttg ctttttgata     4020

tgattttctt gcctgagtgt tggccggagg gactgctggc ccggcctccc ttccgtccag     4080

gcagccgtgc tgcagacaga cctagtgccg agggatggac aggcgaggtg gcagcgtgga     4140

gggctcggcg tggatggcag cctcaggaca cacacccctg cctcaaggtg ctgagccccc     4200

gccttgcact gcgcctgccc cacggtgtcc ccgccgggaa gcagccccgg ctcctgaatc     4260

accctcgctc cgtcaggcgg gactcgtgtc ccagagagga aggggctgct gaggtctgat     4320

ggggcccttc ctccgggtga ccccacaggg cctttccaag cccccatttg agctgctcct     4380

tcctgtgtgt gctctgggcc ctgcctcggc ctcctgcgcc aatactgtga cttccaaaca     4440

atgttactgc tgggcacagc tctgcgttgc tcccgtgctg cctgcgccag ccccaggctg     4500

ctgaggagca gaggccagac cagggccgat ctgggtgtcc tgaccctcag ctggccctgc     4560

ccagccaccc tggacgtgac cgtatccctc tgccacaccc caggccctgc gaggggctat     4620

cgagaggagc tcactgtggg atggggttga cctctgccgc ctgcctgggt atctgggcct     4680

ggccatggct gtgttcttca tgtgttgatt ttatttgacc cctggagtgg tgggtctcat     4740

ctttcccatc tcgcctgaga gcggctgagg gctgcctcac tgcaaatcct ccccacagcg     4800

tcagtgaaag tcgtccttgt ctcagaatga ccaggggcca gccagtgtct gaccaaggtc     4860

aaggggcagg tgcagaggtg gcagggatgg ctccgaagcc agaaatgcct taaactgcaa     4920

cgtcccgtcc cttccccacc cccatcccat ccccaccccc agccccagcc cagtcctcct     4980

aggagcagga cccgatgaag cgggcggcgg tggggctggg tgccgtgtta ctaactctag     5040

tatgtttctg tgtcaatcgc tgtgaaataa agtctgaaaa ctttaaaa                  5088


<210>  418
<211>  7395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of AGRN

<400>  418
agtcccgtcc ccggcgcggc ccgcgcgctc ctccgccgcc tctcgcctgc gccatggccg       60

gccggtccca cccgggcccg ctgcggccgc tgctgccgct ccttgtggtg gccgcgtgcg      120

tcctgcccgg agccggcggg acatgcccgg agcgcgcgct ggagcggcgc gaggaggagg      180

cgaacgtggt gctcaccggg acggtggagg agatcctcaa cgtggacccg gtgcagcaca      240

cgtactcctg caaggttcgg gtctggcggt acttgaaggg caaagacctg gtggcccggg      300

agagcctgct ggacggcggc aacaaggtgg tgatcagcgg ctttggagac cccctcatct      360

gtgacaacca ggtgtccact ggggacacca ggatcttctt tgtgaaccct gcacccccat      420

acctgtggcc agcccacaag aacgagctga tgctcaactc cagcctcatg cggatcaccc      480

tgcggaacct ggaggaggtg gagttctgtg tggaagataa acccgggacc cacttcactc      540

cagtgcctcc gacgcctcct gatgcgtgcc ggggaatgct gtgcggcttc ggcgccgtgt      600

gcgagcccaa cgcggagggg ccgggccggg cgtcctgcgt ctgcaagaag agcccgtgcc      660

ccagcgtggt ggcgcctgtg tgtgggtcgg acgcctccac ctacagcaac gaatgcgagc      720

tgcagcgggc gcagtgcagc cagcagcgcc gcatccgcct gctcagccgc gggccgtgcg      780

gctcgcggga cccctgctcc aacgtgacct gcagcttcgg cagcacctgt gcgcgctcgg      840

ccgacgggct gacggcctcg tgcctgtgcc ccgcgacctg ccgtggcgcc cccgagggga      900

ccgtctgcgg cagcgacggc gccgactacc ccggcgagtg ccagctcctg cgccgcgcct      960

gcgcccgcca ggagaatgtc ttcaagaagt tcgacggccc ttgtgacccc tgtcagggcg     1020

ccctccctga cccgagccgc agctgccgtg tgaacccgcg cacgcggcgc cctgagatgc     1080

tcctacggcc cgagagctgc cctgcccggc aggcgccagt gtgtggggac gacggagtca     1140

cctacgaaaa cgactgtgtc atgggccgat cgggggccgc ccggggtctc ctcctgcaga     1200

aagtgcgctc cggccagtgc cagggtcgag accagtgccc ggagccctgc cggttcaatg     1260

ccgtgtgcct gtcccgccgt ggccgtcccc gctgctcctg cgaccgcgtc acctgtgacg     1320

gggcctacag gcccgtgtgt gcccaggacg ggcgcacgta tgacagtgat tgctggcggc     1380

agcaggctga gtgccggcag cagcgtgcca tccccagcaa gcaccagggc ccgtgtgacc     1440

aggccccgtc cccatgcctc ggggtgcagt gtgcatttgg ggcgacgtgt gctgtgaaga     1500

acgggcaggc agcgtgtgaa tgcctgcagg cgtgctcgag cctctacgat cctgtgtgcg     1560

gcagcgacgg cgtcacatac ggcagcgcgt gcgagctgga ggccacggcc tgtaccctcg     1620

ggcgggagat ccaggtggcg cgcaaaggac cctgtgaccg ctgcgggcag tgccgctttg     1680

gagccctgtg cgaggccgag accgggcgct gcgtgtgccc ctctgaatgc gtggctttgg     1740

cccagcccgt gtgtggctcc gacgggcaca cgtaccccag cgagtgcatg ctgcacgtgc     1800

acgcctgcac acaccagatc agcctgcacg tggcctcagc tggaccctgt gagacctgtg     1860

gagatgccgt gtgtgctttt ggggctgtgt gctccgcagg gcagtgtgtg tgtccccggt     1920

gtgagcaccc cccgcccggc cccgtgtgtg gcagcgacgg tgtcacctac ggcagtgcct     1980

gcgagctacg ggaagccgcc tgcctccagc agacacagat cgaggaggcc cgggcagggc     2040

cgtgcgagca ggccgagtgc ggttccggag gctctggctc tggggaggac ggtgactgtg     2100

agcaggagct gtgccggcag cgcggtggca tctgggacga ggactcggag gacgggccgt     2160

gtgtctgtga cttcagctgc cagagtgtcc caggcagccc ggtgtgcggc tcagatgggg     2220

tcacctacag caccgagtgt gagctgaaga aggccaggtg tgagtcacag cgagggctct     2280

acgtagcggc ccagggagcc tgccgaggcc ccaccttcgc cccgctgccg cctgtggccc     2340

ccttacactg tgcccagacg ccctacggct gctgccagga caatatcacc gcagcccggg     2400

gcgtgggcct ggctggctgc cccagtgcct gccagtgcaa cccccatggc tcttacggcg     2460

gcacctgtga cccagccaca ggccagtgct cctgccgccc aggtgtgggg ggcctcaggt     2520

gtgaccgctg tgagcctggc ttctggaact ttcgaggcat cgtcaccgat ggccggagtg     2580

gctgtacacc ctgcagctgt gatccccaag gcgccgtgcg ggatgactgt gagcagatga     2640

cggggctgtg ctcgtgtaag cccggggtgg ctggacccaa gtgtgggcag tgtccagacg     2700

gccgtgccct gggccccgcg ggctgtgaag ctgacgcttc tgcgcctgcg acctgtgcgg     2760

agatgcgctg tgagttcggt gcgcggtgcg tggaggagtc tggctcagcc cactgtgtct     2820

gcccgatgct cacctgtcca gaggccaacg ctaccaaggt ctgtgggtca gatggagtca     2880

catacggcaa cgagtgtcag ctgaagacca tcgcctgccg ccagggcctg caaatctcta     2940

tccagagcct gggcccgtgc caggaggctg ttgctcccag cactcacccg acatctgcct     3000

ccgtgactgt gaccacccca gggctcctcc tgagccaggc actgccggcc ccccccggcg     3060

ccctccccct ggctcccagc agtaccgcac acagccagac cacccctccg ccctcatcac     3120

gacctcggac cactgccagc gtccccagga ccaccgtgtg gcccgtgctg acggtgcccc     3180

ccacggcacc ctcccctgca cccagcctgg tggcgtccgc ctttggtgaa tctggcagca     3240

ctgatggaag cagcgatgag gaactgagcg gggaccagga ggccagtggg ggtggctctg     3300

gggggctcga gcccttggag ggcagcagcg tggccacccc tgggccacct gtcgagaggg     3360

cttcctgcta caactccgcg ttgggctgct gctctgatgg gaagacgccc tcgctggacg     3420

cagagggctc caactgcccc gccaccaagg tgttccaggg cgtcctggag ctggagggcg     3480

tcgagggcca ggagctgttc tacacgcccg agatggctga ccccaagtca gaactgttcg     3540

gggagacagc caggagcatt gagagcaccc tggacgacct cttccggaat tcagacgtca     3600

agaaggattt tcggagtgtc cgcttgcggg acctggggcc cggcaaatcc gtccgcgcca     3660

ttgtggatgt gcactttgac cccaccacag ccttcagggc acccgacgtg gcccgggccc     3720

tgctccggca gatccaggtg tccaggcgcc ggtccttggg ggtgaggcgg ccgctgcagg     3780

agcacgtgcg atttatggac tttgactggt ttcctgcgtt tatcacgggg gccacgtcag     3840

gagccattgc tgcgggagcc acggccagag ccaccactgc atcgcgcctg ccgtcctctg     3900

ctgtgacccc tcgggccccg caccccagtc acacaagcca gcccgttgcc aagaccacgg     3960

cagcccccac cacacgtcgg ccccccacca ctgcccccag ccgtgtgccc ggacgtcggc     4020

ccccggcccc ccagcagcct ccaaagccct gtgactcaca gccctgcttc cacgggggga     4080

cctgccagga ctgggcattg ggcgggggct tcacctgcag ctgcccggca ggcaggggag     4140

gcgccgtctg tgagaaggtg cttggcgccc ctgtgccggc cttcgagggc cgctccttcc     4200

tggccttccc cactctccgc gcctaccaca cgctgcgcct ggcactggaa ttccgggcgc     4260

tggagcctca ggggctgctg ctgtacaatg gcaacgcccg gggcaaggac ttcctggcat     4320

tggcgctgct agatggccgc gtgcagctca ggtttgacac aggttcgggg ccggcggtgc     4380

tgaccagtgc cgtgccggta gagccgggcc agtggcaccg cctggagctg tcccggcact     4440

ggcgccgggg caccctctcg gtggatggtg agacccctgt tctgggcgag agtcccagtg     4500

gcaccgacgg cctcaacctg gacacagacc tctttgtggg cggcgtaccc gaggaccagg     4560

ctgccgtggc gctggagcgg accttcgtgg gcgccggcct gagggggtgc atccgtttgc     4620

tggacgtcaa caaccagcgc ctggagcttg gcattgggcc gggggctgcc acccgaggct     4680

ctggcgtggg cgagtgcggg gaccacccct gcctgcccaa cccctgccat ggcggggccc     4740

catgccagaa cctggaggct ggaaggttcc attgccagtg cccgcccggc cgcgtcggac     4800

caacctgtgc cgatgagaag agcccctgcc agcccaaccc ctgccatggg gcggcgccct     4860

gccgtgtgct gcccgagggt ggtgctcagt gcgagtgccc cctggggcgt gagggcacct     4920

tctgccagac agcctcgggg caggacggct ctgggccctt cctggctgac ttcaacggct     4980

tctcccacct ggagctgaga ggcctgcaca cctttgcacg ggacctgggg gagaagatgg     5040

cgctggaggt cgtgttcctg gcacgaggcc ccagcggcct cctgctctac aacgggcaga     5100

agacggacgg caagggggac ttcgtgtcgc tggcactgcg ggaccgccgc ctggagttcc     5160

gctacgacct gggcaagggg gcagcggtca tcaggagcag ggagccagtc accctgggag     5220

cctggaccag ggtctcactg gagcgaaacg gccgcaaggg tgccctgcgt gtgggcgacg     5280

gcccccgtgt gttgggggag tccccgaaat cccgcaaggt tccgcacacc gtcctcaacc     5340

tgaaggagcc gctctacgta gggggcgctc ccgacttcag caagctggcc cgtgctgctg     5400

ccgtgtcctc tggcttcgac ggtgccatcc agctggtctc cctcggaggc cgccagctgc     5460

tgaccccgga gcacgtgctg cggcaggtgg acgtcacgtc ctttgcaggt cacccctgca     5520

cccgggcctc aggccacccc tgcctcaatg gggcctcctg cgtcccgagg gaggctgcct     5580

atgtgtgcct gtgtcccggg ggattctcag gaccgcactg cgagaagggg ctggtggaga     5640

agtcagcggg ggacgtggat accttggcct ttgacgggcg gacctttgtc gagtacctca     5700

acgctgtgac cgagagcgaa ctggccaatg agatccccgt ccccgaaact ctggattccg     5760

gggcccttca cagcgagaag gcactgcaga gcaaccactt tgaactgagc ctgcgcactg     5820

aggccacgca ggggctggtg ctctggagtg gcaaggccac ggagcgggca gactatgtgg     5880

cactggccat tgtggacggg cacctgcaac tgagctacaa cctgggctcc cagcccgtgg     5940

tgctgcgttc caccgtgccc gtcaacacca accgctggtt gcgggtcgtg gcacataggg     6000

agcagaggga aggttccctg caggtgggca atgaggcccc tgtgaccggc tcctccccgc     6060

tgggcgccac gcagctggac actgatggag ccctgtggct tgggggcctg ccggagctgc     6120

ccgtgggccc agcactgccc aaggcctacg gcacaggctt tgtgggctgc ttgcgggacg     6180

tggtggtggg ccggcacccg ctgcacctgc tggaggacgc cgtcaccaag ccagagctgc     6240

ggccctgccc caccccatga gctggcacca gagccccgcg cccgctgtaa ttattttcta     6300

tttttgtaaa cttgttgctt tttgatatga ttttcttgcc tgagtgttgg ccggagggac     6360

tgctggcccg gcctcccttc cgtccaggca gccgtgctgc agacagacct agtgccgagg     6420

gatggacagg cgaggtggca gcgtggaggg ctcggcgtgg atggcagcct caggacacac     6480

acccctgcct caaggtgctg agcccccgcc ttgcactgcg cctgccccac ggtgtccccg     6540

ccgggaagca gccccggctc ctgaatcacc ctcgctccgt caggcgggac tcgtgtccca     6600

gagaggaagg ggctgctgag gtctgatggg gcccttcctc cgggtgaccc cacagggcct     6660

ttccaagccc ccatttgagc tgctccttcc tgtgtgtgct ctgggccctg cctcggcctc     6720

ctgcgccaat actgtgactt ccaaacaatg ttactgctgg gcacagctct gcgttgctcc     6780

cgtgctgcct gcgccagccc caggctgctg aggagcagag gccagaccag ggccgatctg     6840

ggtgtcctga ccctcagctg gccctgccca gccaccctgg acgtgaccgt atccctctgc     6900

cacaccccag gccctgcgag gggctatcga gaggagctca ctgtgggatg gggttgacct     6960

ctgccgcctg cctgggtatc tgggcctggc catggctgtg ttcttcatgt gttgatttta     7020

tttgacccct ggagtggtgg gtctcatctt tcccatctcg cctgagagcg gctgagggct     7080

gcctcactgc aaatcctccc cacagcgtca gtgaaagtcg tccttgtctc agaatgacca     7140

ggggccagcc agtgtctgac caaggtcaag gggcaggtgc agaggtggca gggatggctc     7200

cgaagccaga aatgccttaa actgcaacgt cccgtccctt ccccaccccc atcccatccc     7260

cacccccagc cccagcccag tcctcctagg agcaggaccc gatgaagcgg gcggcggtgg     7320

ggctgggtgc cgtgttacta actctagtat gtttctgtgt caatcgctgt gaaataaagt     7380

ctgaaaactt taaaa                                                      7395


<210>  419
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys 
65          


<210>  420
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  420

Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val Ala Arg Glu 
1               5                   10                  15      


Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly Phe Gly Asp 
            20                  25                  30          


Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr Arg Ile Phe 
        35                  40                  45              


Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His Lys Asn Glu 
    50                  55                  60                  


Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg Asn Leu Glu 
65                  70                  75                  80  


Glu Val Glu Phe Cys Val Glu 
                85          


<210>  421
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  421

Lys Pro Gly Thr His Phe Thr Pro Val Pro Pro Thr Pro Pro Asp 
1               5                   10                  15  


<210>  422
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  422

Cys Arg Gly Met Leu Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala 
1               5                   10                  15      


Glu Gly Pro Gly Arg Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro 
            20                  25                  30          


Ser Val Val Ala Pro Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn 
        35                  40                  45              


Glu Cys Glu Leu Gln Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg 
    50                  55                  60                  


Leu Leu Ser Arg Gly Pro Cys 
65                  70      


<210>  423
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  423

Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly Ser Thr Cys 
1               5                   10                  15      


Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys Pro Ala Thr 
            20                  25                  30          


Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp Gly Ala Asp 
        35                  40                  45              


Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala Arg Gln Glu 
    50                  55                  60                  


Asn Val Phe Lys Lys Phe Asp Gly Pro Cys 
65                  70                  


<210>  424
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  424

Pro Cys Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn 
1               5                   10                  15      


Pro Arg Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro 
            20                  25                  30          


Ala Arg Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn 
        35                  40                  45              


Asp Cys Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln 
    50                  55                  60                  


Lys Val Arg Ser Gly Gln Cys Gln Gly Arg 
65                  70                  


<210>  425
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  425

Gln Cys Pro Glu Pro Cys Arg Phe Asn Ala Val Cys Leu Ser Arg Arg 
1               5                   10                  15      


Gly Arg Pro Arg Cys Ser Cys Asp Arg Val Thr Cys Asp Gly Ala Tyr 
            20                  25                  30          


Arg Pro Val Cys Ala Gln Asp Gly Arg Thr Tyr Asp Ser Asp Cys Trp 
        35                  40                  45              


Arg Gln Gln Ala Glu Cys Arg Gln Gln Arg Ala Ile Pro Ser Lys His 
    50                  55                  60                  


Gln Gly Pro Cys 
65              


<210>  426
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  426

Gln Ala Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr 
1               5                   10                  15      


Cys Ala Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys 
            20                  25                  30          


Ser Ser Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
        35                  40                  45              


Ser Ala Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile 
    50                  55                  60                  


Gln Val Ala Arg Lys Gly Pro Cys 
65                  70          


<210>  427
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  427

Arg Cys Gly Gln Cys Arg Phe Gly Ala Leu Cys Glu Ala Glu Thr Gly 
1               5                   10                  15      


Arg Cys Val Cys Pro Ser Glu Cys Val Ala Leu Ala Gln Pro Val Cys 
            20                  25                  30          


Gly Ser Asp Gly His Thr Tyr Pro Ser Glu Cys Met Leu His Val His 
        35                  40                  45              


Ala Cys Thr His Gln Ile Ser Leu His Val Ala Ser Ala Gly Pro Cys 
    50                  55                  60                  


<210>  428
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  428

Thr Cys Gly Asp Ala Val Cys Ala Phe Gly Ala Val Cys Ser Ala Gly 
1               5                   10                  15      


Gln Cys Val Cys Pro Arg Cys Glu His Pro Pro Pro Gly Pro Val Cys 
            20                  25                  30          


Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala Cys Glu Leu Arg Glu Ala 
        35                  40                  45              


Ala Cys Leu Gln Gln Thr Gln Ile Glu Glu Ala Arg Ala Gly Pro Cys 
    50                  55                  60                  


Glu Gln 
65      


<210>  429
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  429

Glu Cys Gly Ser Gly Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu 
1               5                   10                  15      


Gln Glu Leu Cys Arg Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu 
            20                  25                  30          


Asp Gly Pro Cys Val Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser 
        35                  40                  45              


Pro 
    


<210>  430
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  430

Val Cys Gly Ser Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys 
1               5                   10                  15      


Lys Ala Arg Cys Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly 
            20                  25                  30          


Ala Cys Arg 
        35  


<210>  431
<211>  1352
<212>  PRT
<213>  Homo sapiens

<400>  431

Val Cys Gly Ser Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys 
1               5                   10                  15      


Lys Ala Arg Cys Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly 
            20                  25                  30          


Ala Cys Arg Gly Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu 
        35                  40                  45              


His Cys Ala Gln Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala 
    50                  55                  60                  


Ala Arg Gly Val Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn 
65                  70                  75                  80  


Pro His Gly Ser Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys 
                85                  90                  95      


Ser Cys Arg Pro Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro 
            100                 105                 110         


Gly Phe Trp Asn Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys 
        115                 120                 125             


Thr Pro Cys Ser Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu 
    130                 135                 140                 


Gln Met Thr Gly Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys 
145                 150                 155                 160 


Cys Gly Gln Cys Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu 
                165                 170                 175     


Ala Asp Ala Ser Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe 
            180                 185                 190         


Gly Ala Arg Cys Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro 
        195                 200                 205             


Met Leu Thr Cys Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp 
    210                 215                 220                 


Gly Val Thr Tyr Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg 
225                 230                 235                 240 


Gln Gly Leu Gln Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala 
                245                 250                 255     


Val Ala Pro Ser Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr 
            260                 265                 270         


Pro Gly Leu Leu Leu Ser Gln Ala Leu Pro Ala Pro Pro Gly Ala Leu 
        275                 280                 285             


Pro Leu Ala Pro Ser Ser Thr Ala His Ser Gln Thr Thr Pro Pro Pro 
    290                 295                 300                 


Ser Ser Arg Pro Arg Thr Thr Ala Ser Val Pro Arg Thr Thr Val Trp 
305                 310                 315                 320 


Pro Val Leu Thr Val Pro Pro Thr Ala Pro Ser Pro Ala Pro Ser Leu 
                325                 330                 335     


Val Ala Ser Ala Phe Gly Glu Ser Gly Ser Thr Asp Gly Ser Ser Asp 
            340                 345                 350         


Glu Glu Leu Ser Gly Asp Gln Glu Ala Ser Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Leu Glu Pro Leu Glu Gly Ser Ser Val Ala Thr Pro Gly Pro Pro Val 
    370                 375                 380                 


Glu Arg Ala Ser Cys Tyr Asn Ser Ala Leu Gly Cys Cys Ser Asp Gly 
385                 390                 395                 400 


Lys Thr Pro Ser Leu Asp Ala Glu Gly Ser Asn Cys Pro Ala Thr Lys 
                405                 410                 415     


Val Phe Gln Gly Val Leu Glu Leu Glu Gly Val Glu Gly Gln Glu Leu 
            420                 425                 430         


Phe Tyr Thr Pro Glu Met Ala Asp Pro Lys Ser Glu Leu Phe Gly Glu 
        435                 440                 445             


Thr Ala Arg Ser Ile Glu Ser Thr Leu Asp Asp Leu Phe Arg Asn Ser 
    450                 455                 460                 


Asp Val Lys Lys Asp Phe Arg Ser Val Arg Leu Arg Asp Leu Gly Pro 
465                 470                 475                 480 


Gly Lys Ser Val Arg Ala Ile Val Asp Val His Phe Asp Pro Thr Thr 
                485                 490                 495     


Ala Phe Arg Ala Pro Asp Val Ala Arg Ala Leu Leu Arg Gln Ile Gln 
            500                 505                 510         


Val Ser Arg Arg Arg Ser Leu Gly Val Arg Arg Pro Leu Gln Glu His 
        515                 520                 525             


Val Arg Phe Met Asp Phe Asp Trp Phe Pro Ala Phe Ile Thr Gly Ala 
    530                 535                 540                 


Thr Ser Gly Ala Ile Ala Ala Gly Ala Thr Ala Arg Ala Thr Thr Ala 
545                 550                 555                 560 


Ser Arg Leu Pro Ser Ser Ala Val Thr Pro Arg Ala Pro His Pro Ser 
                565                 570                 575     


His Thr Ser Gln Pro Val Ala Lys Thr Thr Ala Ala Pro Thr Thr Arg 
            580                 585                 590         


Arg Pro Pro Thr Thr Ala Pro Ser Arg Val Pro Gly Arg Arg Pro Pro 
        595                 600                 605             


Ala Pro Gln Gln Pro Pro Lys Pro Cys Asp Ser Gln Pro Cys Phe His 
    610                 615                 620                 


Gly Gly Thr Cys Gln Asp Trp Ala Leu Gly Gly Gly Phe Thr Cys Ser 
625                 630                 635                 640 


Cys Pro Ala Gly Arg Gly Gly Ala Val Cys Glu Lys Val Leu Gly Ala 
                645                 650                 655     


Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr Leu 
            660                 665                 670         


Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu Glu 
        675                 680                 685             


Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp Phe 
    690                 695                 700                 


Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp Thr 
705                 710                 715                 720 


Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro Gly 
                725                 730                 735     


Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr Leu 
            740                 745                 750         


Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly Thr 
        755                 760                 765             


Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro Glu 
    770                 775                 780                 


Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly Leu 
785                 790                 795                 800 


Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu Leu 
                805                 810                 815     


Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu Cys 
            820                 825                 830         


Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro Cys 
        835                 840                 845             


Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly Arg 
    850                 855                 860                 


Val Gly Pro Thr Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro Asn Pro 
865                 870                 875                 880 


Cys His Gly Ala Ala Pro Cys Arg Val Leu Pro Glu Gly Gly Ala Gln 
                885                 890                 895     


Cys Glu Cys Pro Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr Ala Ser 
            900                 905                 910         


Gly Gln Asp Gly Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly Phe Ser 
        915                 920                 925             


His Leu Glu Leu Arg Gly Leu His Thr Phe Ala Arg Asp Leu Gly Glu 
    930                 935                 940                 


Lys Met Ala Leu Glu Val Val Phe Leu Ala Arg Gly Pro Ser Gly Leu 
945                 950                 955                 960 


Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val Ser 
                965                 970                 975     


Leu Ala Leu Arg Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu Gly Lys 
            980                 985                 990         


Gly Ala Ala Val Ile Arg Ser Arg  Glu Pro Val Thr Leu  Gly Ala Trp 
        995                 1000                 1005             


Thr Arg  Val Ser Leu Glu Arg  Asn Gly Arg Lys Gly  Ala Leu Arg 
    1010                 1015                 1020             


Val Gly  Asp Gly Pro Arg Val  Leu Gly Glu Ser Pro  Lys Ser Arg 
    1025                 1030                 1035             


Lys Val  Pro His Thr Val Leu  Asn Leu Lys Glu Pro  Leu Tyr Val 
    1040                 1045                 1050             


Gly Gly  Ala Pro Asp Phe Ser  Lys Leu Ala Arg Ala  Ala Ala Val 
    1055                 1060                 1065             


Ser Ser  Gly Phe Asp Gly Ala  Ile Gln Leu Val Ser  Leu Gly Gly 
    1070                 1075                 1080             


Arg Gln  Leu Leu Thr Pro Glu  His Val Leu Arg Gln  Val Asp Val 
    1085                 1090                 1095             


Thr Ser  Phe Ala Gly His Pro  Cys Thr Arg Ala Ser  Gly His Pro 
    1100                 1105                 1110             


Cys Leu  Asn Gly Ala Ser Cys  Val Pro Arg Glu Ala  Ala Tyr Val 
    1115                 1120                 1125             


Cys Leu  Cys Pro Gly Gly Phe  Ser Gly Pro His Cys  Glu Lys Gly 
    1130                 1135                 1140             


Leu Val  Glu Lys Ser Ala Gly  Asp Val Asp Thr Leu  Ala Phe Asp 
    1145                 1150                 1155             


Gly Arg  Thr Phe Val Glu Tyr  Leu Asn Ala Val Thr  Glu Ser Glu 
    1160                 1165                 1170             


Leu Ala  Asn Glu Ile Pro Val  Pro Glu Thr Leu Asp  Ser Gly Ala 
    1175                 1180                 1185             


Leu His  Ser Glu Lys Ala Leu  Gln Ser Asn His Phe  Glu Leu Ser 
    1190                 1195                 1200             


Leu Arg  Thr Glu Ala Thr Gln  Gly Leu Val Leu Trp  Ser Gly Lys 
    1205                 1210                 1215             


Ala Thr  Glu Arg Ala Asp Tyr  Val Ala Leu Ala Ile  Val Asp Gly 
    1220                 1225                 1230             


His Leu  Gln Leu Ser Tyr Asn  Leu Gly Ser Gln Pro  Val Val Leu 
    1235                 1240                 1245             


Arg Ser  Thr Val Pro Val Asn  Thr Asn Arg Trp Leu  Arg Val Val 
    1250                 1255                 1260             


Ala His  Arg Glu Gln Arg Glu  Gly Ser Leu Gln Val  Gly Asn Glu 
    1265                 1270                 1275             


Ala Pro  Val Thr Gly Ser Ser  Pro Leu Gly Ala Thr  Gln Leu Asp 
    1280                 1285                 1290             


Thr Asp  Gly Ala Leu Trp Leu  Gly Gly Leu Pro Glu  Leu Pro Val 
    1295                 1300                 1305             


Gly Pro  Ala Leu Pro Lys Ala  Tyr Gly Thr Gly Phe  Val Gly Cys 
    1310                 1315                 1320             


Leu Arg  Asp Val Val Val Gly  Arg His Pro Leu His  Leu Leu Glu 
    1325                 1330                 1335             


Asp Ala  Val Thr Lys Pro Glu  Leu Arg Pro Cys Pro  Thr Pro 
    1340                 1345                 1350         


<210>  432
<211>  2068
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Leu  Ala Asn Glu 
    1880                 1885                 1890             


Ile Pro  Val Pro Glu Thr Leu  Asp Ser Gly Ala Leu  His Ser Glu 
    1895                 1900                 1905             


Lys Ala  Leu Gln Ser Asn His  Phe Glu Leu Ser Leu  Arg Thr Glu 
    1910                 1915                 1920             


Ala Thr  Gln Gly Leu Val Leu  Trp Ser Gly Lys Ala  Thr Glu Arg 
    1925                 1930                 1935             


Ala Asp  Tyr Val Ala Leu Ala  Ile Val Asp Gly His  Leu Gln Leu 
    1940                 1945                 1950             


Ser Tyr  Asn Leu Gly Ser Gln  Pro Val Val Leu Arg  Ser Thr Val 
    1955                 1960                 1965             


Pro Val  Asn Thr Asn Arg Trp  Leu Arg Val Val Ala  His Arg Glu 
    1970                 1975                 1980             


Gln Arg  Glu Gly Ser Leu Gln  Val Gly Asn Glu Ala  Pro Val Thr 
    1985                 1990                 1995             


Gly Ser  Ser Pro Leu Gly Ala  Thr Gln Leu Asp Thr  Asp Gly Ala 
    2000                 2005                 2010             


Leu Trp  Leu Gly Gly Leu Pro  Glu Leu Pro Val Gly  Pro Ala Leu 
    2015                 2020                 2025             


Pro Lys  Ala Tyr Gly Thr Gly  Phe Val Gly Cys Leu  Arg Asp Val 
    2030                 2035                 2040             


Val Val  Gly Arg His Pro Leu  His Leu Leu Glu Asp  Ala Val Thr 
    2045                 2050                 2055             


Lys Pro  Glu Leu Arg Pro Cys  Pro Thr Pro 
    2060                 2065             


<210>  433
<211>  2307
<212>  DNA
<213>  Homo sapiens

<400>  433
agtcccgtcc ccggcgcggc ccgcgcgctc ctccgccgcc tctcgcctgc gccatggccg       60

gccggtccca cccgggcccg ctgcggccgc tgctgccgct ccttgtggtg gccgcgtgcg      120

tcctgcccgg agccggcggg acatgcccgg agcgcgcgct ggagcggcgc gaggaggagg      180

cgaacgtggt gctcaccggg acggtggagg agatcctcaa cgtggacccg gtgcagcaca      240

cgtactcctg caaggttcgg gtctggcggt acttgaaggg caaagacctg gtggcccggg      300

agagcctgct ggacggcggc aacaaggtgg tgatcagcgg ctttggagac cccctcatct      360

gtgacaacca ggtgtccact ggggacacca ggatcttctt tgtgaaccct gcacccccat      420

acctgtggcc agcccacaag aacgagctga tgctcaactc cagcctcatg cggatcaccc      480

tgcggaacct ggaggaggtg gagttctgtg tggaagataa acccgggacc cacttcactc      540

cagtgcctcc gacgcctcct gatgcgtgcc ggggaatgct gtgcggcttc ggcgccgtgt      600

gcgagcccaa cgcggagggg ccgggccggg cgtcctgcgt ctgcaagaag agcccgtgcc      660

ccagcgtggt ggcgcctgtg tgtgggtcgg acgcctccac ctacagcaac gaatgcgagc      720

tgcagcgggc gcagtgcagc cagcagcgcc gcatccgcct gctcagccgc gggccgtgcg      780

gctcgcggga cccctgctcc aacgtgacct gcagcttcgg cagcacctgt gcgcgctcgg      840

ccgacgggct gacggcctcg tgcctgtgcc ccgcgacctg ccgtggcgcc cccgagggga      900

ccgtctgcgg cagcgacggc gccgactacc ccggcgagtg ccagctcctg cgccgcgcct      960

gcgcccgcca ggagaatgtc ttcaagaagt tcgacggccc ttgtgacccc tgtcagggcg     1020

ccctccctga cccgagccgc agctgccgtg tgaacccgcg cacgcggcgc cctgagatgc     1080

tcctacggcc cgagagctgc cctgcccggc aggcgccagt gtgtggggac gacggagtca     1140

cctacgaaaa cgactgtgtc atgggccgat cgggggccgc ccggggtctc ctcctgcaga     1200

aagtgcgctc cggccagtgc cagggtcgag accagtgccc ggagccctgc cggttcaatg     1260

ccgtgtgcct gtcccgccgt ggccgtcccc gctgctcctg cgaccgcgtc acctgtgacg     1320

gggcctacag gcccgtgtgt gcccaggacg ggcgcacgta tgacagtgat tgctggcggc     1380

agcaggctga gtgccggcag cagcgtgcca tccccagcaa gcaccagggc ccgtgtgacc     1440

aggccccgtc cccatgcctc ggggtgcagt gtgcatttgg ggcgacgtgt gctgtgaaga     1500

acgggcaggc agcgtgtgaa tgcctgcagg cgtgctcgag cctctacgat cctgtgtgcg     1560

gcagcgacgg cgtcacatac ggcagcgcgt gcgagctgga ggccacggcc tgtaccctcg     1620

ggcgggagat ccaggtggcg cgcaaaggac cctgtgaccg ctgcgggcag tgccgctttg     1680

gagccctgtg cgaggccgag accgggcgct gcgtgtgccc ctctgaatgc gtggctttgg     1740

cccagcccgt gtgtggctcc gacgggcaca cgtaccccag cgagtgcatg ctgcacgtgc     1800

acgcctgcac acaccagatc agcctgcacg tggcctcagc tggaccctgt gagacctgtg     1860

gagatgccgt gtgtgctttt ggggctgtgt gctccgcagg gcagtgtgtg tgtccccggt     1920

gtgagcaccc cccgcccggc cccgtgtgtg gcagcgacgg tgtcacctac ggcagtgcct     1980

gcgagctacg ggaagccgcc tgcctccagc agacacagat cgaggaggcc cgggcagggc     2040

cgtgcgagca ggccgagtgc ggttccggag gctctggctc tggggaggac ggtgactgtg     2100

agcaggagct gtgccggcag cgcggtggca tctgggacga ggactcggag gacgggccgt     2160

gtgtctgtga cttcagctgc cagagtgtcc caggcagccc ggtgtgcggc tcagatgggg     2220

tcacctacag caccgagtgt gagctgaaga aggccaggtg tgagtcacag cgagggctct     2280

acgtagcggc ccagggagcc tgccgag                                         2307


<210>  434
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg 
            740                 745                 750     


<210>  435
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  435
taaaaggctt ctccccagat gccagagacc tgtctgctaa agaaaccaag atgctgatgg       60

ctgctggaga caaagatggg gacggcaaaa ttggggttga cg                         102


<210>  436
<211>  125
<212>  DNA
<213>  Homo sapiens

<400>  436
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgcttca tggtgaaaga cctttcaaac ccctcgagat      120

acttg                                                                  125


<210>  437
<211>  227
<212>  DNA
<213>  Homo sapiens

<400>  437
taaaaggctt ctccccagat gccagagacc tgtctgctaa agaaaccaag atgctgatgg       60

ctgctggaga caaagatggg gacggcaaaa ttggggttga cgctacatct acatccacca      120

ctgggacaag ccatcttgta aaatgtgcgg agaaggagaa aactttctgt gtgaatggag      180

gggagtgctt catggtgaaa gacctttcaa acccctcgag atacttg                    227


<210>  438
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  438

Lys Gly Phe Ser Pro Asp Ala Arg Asp Leu Ser Ala Lys Glu Thr Lys 
1               5                   10                  15      


Met Leu Met Ala Ala Gly Asp Lys Asp Gly Asp Gly Lys Ile Gly Val 
            20                  25                  30          


Asp Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys 
        35                  40                  45              


Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys Phe Met 
    50                  55                  60                  


Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr Leu 
65                  70                  75  


<210>  439
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  439
acttcccgac aggacttccc accagcccag cctttcagtg caggctccag ccctccaccc       60

ccacccgag                                                               69


<210>  440
<211>  68
<212>  DNA
<213>  Homo sapiens

<400>  440
ttgcaggatg tcgatgacag acttgctgaa cgctgaggac atcaagaagg cggtgggagc       60

ctttagcg                                                                68


<210>  441
<211>  133
<212>  DNA
<213>  Homo sapiens

<400>  441
ctaccgactc cttcgaccac aaaaagttct tccaaatggt cggcctgaag aaaaagagtg       60

cggatgatgt gaagaaggtg tttcacatgc tggacaagga caaaagtggc ttcatcgagg      120

aggatgagct ggg                                                         133


<210>  442
<211>  110
<212>  DNA
<213>  Homo sapiens

<400>  442
attcatccta aaaggcttct ccccagatgc cagagacctg tctgctaaag aaaccaagat       60

gctgatggct gctggagaca aagatgggga cggcaaaatt ggggttgacg                 110


<210>  443
<211>  216
<212>  DNA
<213>  Homo sapiens

<400>  443
aattctccac tctggtggct gaaagctaag aagcactgac tgcccctggt cttccacctc       60

tctgccctga acacccaatc tcggcccctc tcgccaccct cctgcatttc tgttcagttc      120

gtttatgtta ttttttactc ccccatcccc tgtggccctc taatgacacc attcttctgg      180

aaaatgctgg agaagcaata aaggttgtac cagtca                                216


<210>  444
<211>  596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of PVALB

<400>  444
acttcccgac aggacttccc accagcccag cctttcagtg caggctccag ccctccaccc       60

ccacccgagt tgcaggatgt cgatgacaga cttgctgaac gctgaggaca tcaagaaggc      120

ggtgggagcc tttagcgcta ccgactcctt cgaccacaaa aagttcttcc aaatggtcgg      180

cctgaagaaa aagagtgcgg atgatgtgaa gaaggtgttt cacatgctgg acaaggacaa      240

aagtggcttc atcgaggagg atgagctggg attcatccta aaaggcttct ccccagatgc      300

cagagacctg tctgctaaag aaaccaagat gctgatggct gctggagaca aagatgggga      360

cggcaaaatt ggggttgacg aattctccac tctggtggct gaaagctaag aagcactgac      420

tgcccctggt cttccacctc tctgccctga acacccaatc tcggcccctc tcgccaccct      480

cctgcatttc tgttcagttc gtttatgtta ttttttactc ccccatcccc tgtggccctc      540

taatgacacc attcttctgg aaaatgctgg agaagcaata aaggttgtac cagtca          596


<210>  445
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Ser Met Thr Asp Leu Leu Asn Ala Glu Asp Ile Lys Lys Ala Val 
1               5                   10                  15      


Gly Ala Phe Ser 
            20  


<210>  446
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  446

Thr Asp Ser Phe Asp His Lys Lys Phe Phe Gln Met Val Gly Leu Lys 
1               5                   10                  15      


Lys Lys Ser Ala Asp Asp Val Lys Lys Val Phe His Met Leu Asp Lys 
            20                  25                  30          


Asp Lys Ser Gly Phe Ile Glu Glu Asp Glu Leu 
        35                  40              


<210>  447
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  447

Phe Ile Leu Lys Gly Phe Ser Pro Asp Ala Arg Asp Leu Ser Ala Lys 
1               5                   10                  15      


Glu Thr Lys Met Leu Met Ala Ala Gly Asp Lys Asp Gly Asp Gly Lys 
            20                  25                  30          


Ile Gly Val Asp 
        35      


<210>  448
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  448

Phe Ser Thr Leu Val Ala Glu Ser 
1               5               


<210>  449
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Ser Met Thr Asp Leu Leu Asn Ala Glu Asp Ile Lys Lys Ala Val 
1               5                   10                  15      


Gly Ala Phe Ser Ala Thr Asp Ser Phe Asp His Lys Lys Phe Phe Gln 
            20                  25                  30          


Met Val Gly Leu Lys Lys Lys Ser Ala Asp Asp Val Lys Lys Val Phe 
        35                  40                  45              


His Met Leu Asp Lys Asp Lys Ser Gly Phe Ile Glu Glu Asp Glu Leu 
    50                  55                  60                  


Gly Phe Ile Leu Lys Gly Phe Ser Pro Asp Ala Arg Asp Leu Ser Ala 
65                  70                  75                  80  


Lys Glu Thr Lys Met Leu Met Ala Ala Gly Asp Lys Asp Gly Asp Gly 
                85                  90                  95      


Lys Ile Gly Val Asp Glu Phe Ser Thr Leu Val Ala Glu Ser 
            100                 105                 110 


<210>  450
<211>  380
<212>  DNA
<213>  Homo sapiens

<400>  450
acttcccgac aggacttccc accagcccag cctttcagtg caggctccag ccctccaccc       60

ccacccgagt tgcaggatgt cgatgacaga cttgctgaac gctgaggaca tcaagaaggc      120

ggtgggagcc tttagcgcta ccgactcctt cgaccacaaa aagttcttcc aaatggtcgg      180

cctgaagaaa aagagtgcgg atgatgtgaa gaaggtgttt cacatgctgg acaaggacaa      240

aagtggcttc atcgaggagg atgagctggg attcatccta aaaggcttct ccccagatgc      300

cagagacctg tctgctaaag aaaccaagat gctgatggct gctggagaca aagatgggga      360

cggcaaaatt ggggttgacg                                                  380


<210>  451
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Ser Met Thr Asp Leu Leu Asn Ala Glu Asp Ile Lys Lys Ala Val 
1               5                   10                  15      


Gly Ala Phe Ser Ala Thr Asp Ser Phe Asp His Lys Lys Phe Phe Gln 
            20                  25                  30          


Met Val Gly Leu Lys Lys Lys Ser Ala Asp Asp Val Lys Lys Val Phe 
        35                  40                  45              


His Met Leu Asp Lys Asp Lys Ser Gly Phe Ile Glu Glu Asp Glu Leu 
    50                  55                  60                  


Gly Phe Ile Leu Lys Gly Phe Ser Pro Asp Ala Arg Asp Leu Ser Ala 
65                  70                  75                  80  


Lys Glu Thr Lys Met Leu Met Ala Ala Gly Asp Lys Asp Gly Asp Gly 
                85                  90                  95      


Lys Ile Gly Val Asp 
            100     


<210>  452
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  452
agttggggtc tcactgtgtt gcccagactg gtctcgaact cttggcctca ggtgatcctc       60

ttccctcagc ttcccagaat gccgagatga tag                                    93


<210>  453
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  453
ctacatctac atccaccact gggacaag                                          28


<210>  454
<211>  121
<212>  DNA
<213>  Homo sapiens

<400>  454
agttggggtc tcactgtgtt gcccagactg gtctcgaact cttggcctca ggtgatcctc       60

ttccctcagc ttcccagaat gccgagatga tagctacatc tacatccacc actgggacaa      120

g                                                                      121


<210>  455
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  455

Leu Gly Ser His Cys Val Ala Gln Thr Gly Leu Glu Leu Leu Ala Ser 
1               5                   10                  15      


Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn Ala Glu Met Ile Ala Thr 
            20                  25                  30          


Ser Thr Ser Thr Thr Gly Thr 
        35                  


<210>  456
<211>  273
<212>  DNA
<213>  Homo sapiens

<400>  456
gcattgcggc ttggttttct cacccagtgc atgtggcagg agcggtgaga tcactgcctc       60

acggcgatcc tggactgacg gtcacgactg cctaccctct aaccctgttc tgagctgccc      120

cttgcccaca caccccaaac ctgtgtgcag gatccgcctc catggagcta cagcctcctg      180

aagcctcgat cgccgtcgtg tcgattccgc gccagttgcc tggctcacat tcggaggctg      240

gtgtccaggg tctcagcgcg ggggacgact cag                                   273


<210>  457
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  457
agttggggtc tcactgtgtt gcccagactg gtctcgaact cttggcctca ggtgatcctc       60

ttccctcagc ttcccagaat gccgagatga tag                                    93


<210>  458
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  458
agacggggtc tgactgtgtt acccaggctg gtcttcaact cttggcctca agtgatcctc       60

ctgccttagc ttccaagaat gctgaggtta cag                                    93


<210>  459
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  459
gcaccatgag ccaggacacc gaggtggata tgaaggaggt ggagctgaat gagttagagc       60

ccgagaagca gccgatgaac gcggcgtctg gggcggccat gtccctggcg ggagccgaga      120

agaatggtct ggtgaagatc aaggtggcgg aagacgaggc ggaggcggca gccgcggcta      180

agttcacggg cctgtccaag gaggagctgc tgaaggtggc aggcagcccc ggctgggtac      240

gcacccgctg ggcactgctg ctgctcttct ggctcggctg gctcggcatg cttgctggtg      300

ccgtggtcat aatcgtgcga gcgccgcgtt gtcgcgagct accggcgcag aagtggtggc      360

acacgggcgc cctctaccgc atcggcgacc ttcaggcctt ccagggccac ggcgcgggca      420

acctggcgg                                                              429


<210>  460
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  460
gtctgaaggg gcgtctcgat tacctgagct ctctgaaggt gaagggcctt gtgctgggtc       60

caattcacaa gaaccagaag gatgatgtcg ctcagactga cttgctgcag atcgacccca      120

attttggctc caaggaagat tttgacagtc tcttgcaatc ggctaaaaaa aaga            174


<210>  461
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  461
gcatccgtgt cattctggac cttactccca actaccgggg tgagaactcg tggttctcca       60

ctcaggttga cactgtggcc accaaggtga ag                                     92


<210>  462
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  462
gatgctctgg agttttggct gcaagctggc gtggatgggt tccaggttcg ggacatagag       60

aatctgaag                                                               69


<210>  463
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  463
gatgcatcct cattcttggc tgagtggcaa aatatcacca agggcttcag tgaagacag        59


<210>  464
<211>  181
<212>  DNA
<213>  Homo sapiens

<400>  464
gctcttgatt gcggggacta actcctccga ccttcagcag atcctgagcc tactcgaatc       60

caacaaagac ttgctgttga ctagctcata cctgtctgat tctggttcta ctggggagca      120

tacaaaatcc ctagtcacac agtatttgaa tgccactggc aatcgctggt gcagctggag      180

t                                                                      181


<210>  465
<211>  144
<212>  DNA
<213>  Homo sapiens

<400>  465
ttgtctcagg caaggctcct gacttccttc ttgccggctc aacttctccg actctaccag       60

ctgatgctct tcaccctgcc agggacccct gttttcagct acggggatga gattggcctg      120

gatgcagctg cccttcctgg acag                                             144


<210>  466
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  466
cctatggagg ctccagtcat gctgtgggat gagtccagct tccctgacat cccaggggct       60

gtaagtgcca acatgactgt gaag                                              84


<210>  467
<211>  530
<212>  DNA
<213>  Homo sapiens

<400>  467
ggccagagtg aagaccctgg ctccctcctt tccttgttcc ggcggctgag tgaccagcgg       60

agtaaggagc gctccctact gcatggggac ttccacgcgt tctccgctgg gcctggactc      120

ttctcctata tccgccactg ggaccagaat gagcgttttc tggtagtgct taactttggg      180

gatgtgggcc tctcggctgg actgcaggcc tccgacctgc ctgccagcgc cagcctgcca      240

gccaaggctg acctcctgct cagcacccag ccaggccgtg aggagggctc ccctcttgag      300

ctggaacgcc tgaaactgga gcctcacgaa gggctgctgc tccgcttccc ctacgcggcc      360

tgacttcagc ctgacatgga cccactaccc ttctcctttc cttcccaggc cctttggctt      420

ctgatttttc tcttttttaa aaacaaacaa acaaactgtt gcagattatg agtgaacccc      480

caaatagggt gttttctgcc ttcaaataaa agtcacccct gcatggtgaa                 530


<210>  468
<211>  2221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of SLC3A2

<400>  468
gcattgcggc ttggttttct cacccagtgc atgtggcagg agcggtgaga tcactgcctc       60

acggcgatcc tggactgacg gtcacgactg cctaccctct aaccctgttc tgagctgccc      120

cttgcccaca caccccaaac ctgtgtgcag gatccgcctc catggagcta cagcctcctg      180

aagcctcgat cgccgtcgtg tcgattccgc gccagttgcc tggctcacat tcggaggctg      240

gtgtccaggg tctcagcgcg ggggacgact cagagttggg gtctcactgt gttgcccaga      300

ctggtctcga actcttggcc tcaggtgatc ctcttccctc agcttcccag aatgccgaga      360

tgatagagac ggggtctgac tgtgttaccc aggctggtct tcaactcttg gcctcaagtg      420

atcctcctgc cttagcttcc aagaatgctg aggttacagg caccatgagc caggacaccg      480

aggtggatat gaaggaggtg gagctgaatg agttagagcc cgagaagcag ccgatgaacg      540

cggcgtctgg ggcggccatg tccctggcgg gagccgagaa gaatggtctg gtgaagatca      600

aggtggcgga agacgaggcg gaggcggcag ccgcggctaa gttcacgggc ctgtccaagg      660

aggagctgct gaaggtggca ggcagccccg gctgggtacg cacccgctgg gcactgctgc      720

tgctcttctg gctcggctgg ctcggcatgc ttgctggtgc cgtggtcata atcgtgcgag      780

cgccgcgttg tcgcgagcta ccggcgcaga agtggtggca cacgggcgcc ctctaccgca      840

tcggcgacct tcaggccttc cagggccacg gcgcgggcaa cctggcgggt ctgaaggggc      900

gtctcgatta cctgagctct ctgaaggtga agggccttgt gctgggtcca attcacaaga      960

accagaagga tgatgtcgct cagactgact tgctgcagat cgaccccaat tttggctcca     1020

aggaagattt tgacagtctc ttgcaatcgg ctaaaaaaaa gagcatccgt gtcattctgg     1080

accttactcc caactaccgg ggtgagaact cgtggttctc cactcaggtt gacactgtgg     1140

ccaccaaggt gaaggatgct ctggagtttt ggctgcaagc tggcgtggat gggttccagg     1200

ttcgggacat agagaatctg aaggatgcat cctcattctt ggctgagtgg caaaatatca     1260

ccaagggctt cagtgaagac aggctcttga ttgcggggac taactcctcc gaccttcagc     1320

agatcctgag cctactcgaa tccaacaaag acttgctgtt gactagctca tacctgtctg     1380

attctggttc tactggggag catacaaaat ccctagtcac acagtatttg aatgccactg     1440

gcaatcgctg gtgcagctgg agtttgtctc aggcaaggct cctgacttcc ttcttgccgg     1500

ctcaacttct ccgactctac cagctgatgc tcttcaccct gccagggacc cctgttttca     1560

gctacgggga tgagattggc ctggatgcag ctgcccttcc tggacagcct atggaggctc     1620

cagtcatgct gtgggatgag tccagcttcc ctgacatccc aggggctgta agtgccaaca     1680

tgactgtgaa gggccagagt gaagaccctg gctccctcct ttccttgttc cggcggctga     1740

gtgaccagcg gagtaaggag cgctccctac tgcatgggga cttccacgcg ttctccgctg     1800

ggcctggact cttctcctat atccgccact gggaccagaa tgagcgtttt ctggtagtgc     1860

ttaactttgg ggatgtgggc ctctcggctg gactgcaggc ctccgacctg cctgccagcg     1920

ccagcctgcc agccaaggct gacctcctgc tcagcaccca gccaggccgt gaggagggct     1980

cccctcttga gctggaacgc ctgaaactgg agcctcacga agggctgctg ctccgcttcc     2040

cctacgcggc ctgacttcag cctgacatgg acccactacc cttctccttt ccttcccagg     2100

ccctttggct tctgattttt ctctttttta aaaacaaaca aacaaactgt tgcagattat     2160

gagtgaaccc ccaaataggg tgttttctgc cttcaaataa aagtcacccc tgcatggtga     2220

a                                                                     2221


<210>  469
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  469

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser 
        35          


<210>  470
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  470

Leu Gly Ser His Cys Val Ala Gln Thr Gly Leu Glu Leu Leu Ala Ser 
1               5                   10                  15      


Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn Ala Glu Met Ile 
            20                  25                  30  


<210>  471
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  471

Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu Gln Leu Leu Ala Ser 
1               5                   10                  15      


Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala Glu Val Thr 
            20                  25                  30  


<210>  472
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  472

Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn 
1               5                   10                  15      


Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala 
            20                  25                  30          


Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val 
        35                  40                  45              


Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu 
    50                  55                  60                  


Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg 
65                  70                  75                  80  


Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met 
                85                  90                  95      


Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu 
            100                 105                 110         


Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly 
        115                 120                 125             


Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala 
    130                 135                 140         


<210>  473
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  473

Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu 
1               5                   10                  15      


Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr 
            20                  25                  30          


Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp 
        35                  40                  45              


Ser Leu Leu Gln Ser Ala Lys Lys Lys 
    50                  55          


<210>  474
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  474

Ile Arg Val Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser 
1               5                   10                  15      


Trp Phe Ser Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys 
            20                  25                  30  


<210>  475
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  475

Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val 
1               5                   10                  15      


Arg Asp Ile Glu Asn Leu Lys 
            20              


<210>  476
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  476

Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe 
1               5                   10                  15      


Ser Glu Asp 
            


<210>  477
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  477

Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu Ser 
1               5                   10                  15      


Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu Ser 
            20                  25                  30          


Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln Tyr 
        35                  40                  45              


Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser 
    50                  55                  60  


<210>  478
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  478

Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu 
1               5                   10                  15      


Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe 
            20                  25                  30          


Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln 
        35                  40                  45              


<210>  479
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  479

Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp 
1               5                   10                  15      


Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys 
            20                  25              


<210>  480
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  480

Gly Gln Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu 
1               5                   10                  15      


Ser Asp Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His 
            20                  25                  30          


Ala Phe Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp 
        35                  40                  45              


Gln Asn Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu 
    50                  55                  60                  


Ser Ala Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro 
65                  70                  75                  80  


Ala Lys Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly 
                85                  90                  95      


Ser Pro Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu 
            100                 105                 110         


Leu Leu Arg Phe Pro Tyr Ala Ala 
        115                 120 


<210>  481
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  481

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile Glu Thr Gly Ser Asp Cys Val Thr Gln Ala Gly Leu 
65                  70                  75                  80  


Gln Leu Leu Ala Ser Ser Asp Pro Pro Ala Leu Ala Ser Lys Asn Ala 
                85                  90                  95      


Glu Val Thr Gly Thr Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu 
            100                 105                 110         


Val Glu Leu Asn Glu Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala 
        115                 120                 125             


Ser Gly Ala Ala Met Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val 
    130                 135                 140                 


Lys Ile Lys Val Ala Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Phe Thr Gly Leu Ser Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro 
                165                 170                 175     


Gly Trp Val Arg Thr Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly 
            180                 185                 190         


Trp Leu Gly Met Leu Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro 
        195                 200                 205             


Arg Cys Arg Glu Leu Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu 
    210                 215                 220                 


Tyr Arg Ile Gly Asp Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn 
225                 230                 235                 240 


Leu Ala Gly Leu Lys Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val 
                245                 250                 255     


Lys Gly Leu Val Leu Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val 
            260                 265                 270         


Ala Gln Thr Asp Leu Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu 
        275                 280                 285             


Asp Phe Asp Ser Leu Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val 
    290                 295                 300                 


Ile Leu Asp Leu Thr Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser 
305                 310                 315                 320 


Thr Gln Val Asp Thr Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe 
                325                 330                 335     


Trp Leu Gln Ala Gly Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn 
            340                 345                 350         


Leu Lys Asp Ala Ser Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys 
        355                 360                 365             


Gly Phe Ser Glu Asp Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp 
    370                 375                 380                 


Leu Gln Gln Ile Leu Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu 
385                 390                 395                 400 


Thr Ser Ser Tyr Leu Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys 
                405                 410                 415     


Ser Leu Val Thr Gln Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser 
            420                 425                 430         


Trp Ser Leu Ser Gln Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln 
        435                 440                 445             


Leu Leu Arg Leu Tyr Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro 
    450                 455                 460                 


Val Phe Ser Tyr Gly Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro 
465                 470                 475                 480 


Gly Gln Pro Met Glu Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe 
                485                 490                 495     


Pro Asp Ile Pro Gly Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln 
            500                 505                 510         


Ser Glu Asp Pro Gly Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp 
        515                 520                 525             


Gln Arg Ser Lys Glu Arg Ser Leu Leu His Gly Asp Phe His Ala Phe 
    530                 535                 540                 


Ser Ala Gly Pro Gly Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn 
545                 550                 555                 560 


Glu Arg Phe Leu Val Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala 
                565                 570                 575     


Gly Leu Gln Ala Ser Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys 
            580                 585                 590         


Ala Asp Leu Leu Leu Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro 
        595                 600                 605             


Leu Glu Leu Glu Arg Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu 
    610                 615                 620                 


Arg Phe Pro Tyr Ala Ala 
625                 630 


<210>  482
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  482
gcattgcggc ttggttttct cacccagtgc atgtggcagg agcggtgaga tcactgcctc       60

acggcgatcc tggactgacg gtcacgactg cctaccctct aaccctgttc tgagctgccc      120

cttgcccaca caccccaaac ctgtgtgcag gatccgcctc catggagcta cagcctcctg      180

aagcctcgat cgccgtcgtg tcgattccgc gccagttgcc tggctcacat tcggaggctg      240

gtgtccaggg tctcagcgcg ggggacgact cagagttggg gtctcactgt gttgcccaga      300

ctggtctcga actcttggcc tcaggtgatc ctcttccctc agcttcccag aatgccgaga      360

tgatag                                                                 366


<210>  483
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  483

Met Glu Leu Gln Pro Pro Glu Ala Ser Ile Ala Val Val Ser Ile Pro 
1               5                   10                  15      


Arg Gln Leu Pro Gly Ser His Ser Glu Ala Gly Val Gln Gly Leu Ser 
            20                  25                  30          


Ala Gly Asp Asp Ser Glu Leu Gly Ser His Cys Val Ala Gln Thr Gly 
        35                  40                  45              


Leu Glu Leu Leu Ala Ser Gly Asp Pro Leu Pro Ser Ala Ser Gln Asn 
    50                  55                  60                  


Ala Glu Met Ile 
65              


<210>  484
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  484
ttgagcctgt tgatgcccgc cctgctgccg accgaggact gaccactcga ccag             54


<210>  485
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  485
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgct                                           87


<210>  486
<211>  141
<212>  DNA
<213>  Homo sapiens

<400>  486
ttgagcctgt tgatgcccgc cctgctgccg accgaggact gaccactcga ccagctacat       60

ctacatccac cactgggaca agccatcttg taaaatgtgc ggagaaggag aaaactttct      120

gtgtgaatgg aggggagtgc t                                                141


<210>  487
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  487

Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg 
1               5                   10                  15      


Pro Ala Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys 
            20                  25                  30          


Ala Glu Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys 
        35                  40                  45      


<210>  488
<211>  207
<212>  DNA
<213>  Homo sapiens

<400>  488
gtcagtttcc tcggcagcgg taggcgagag cacgcggagg agcgtgcgcg ggggccccgg       60

gagacggcgg cggtggcggc gcgggcagag caaggacgcg gcggatccca ctcgcacagc      120

agcgcactcg gtgccccgcg cagggtcgcg atgctgcccg gtttggcact gctcctgctg      180

gccgcctgga cggctcgggc gctggag                                          207


<210>  489
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  489
gtctaccctg aactgcagat caccaatgtg gtagaagcca accaaccagt gaccatccag       60

aactggtgca agcggggccg caagcagtgc aagacccatc cccactttgt gattccctac      120

cgctgcttag                                                             130


<210>  490
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  490
ttggtgagtt tgtaagtgat gcccttctcg ttcctgacaa gtgcaaattc ttacaccagg       60

agaggatgga tgtttgcgaa actcatcttc actggcacac cgtcgccaaa gag             113


<210>  491
<211>  194
<212>  DNA
<213>  Homo sapiens

<400>  491
acatgcagtg agaagagtac caacttgcat gactacggca tgttgctgcc ctgcggaatt       60

gacaagttcc gaggggtaga gtttgtgtgt tgcccactgg ctgaagaaag tgacaatgtg      120

gattctgctg atgcggagga ggatgactcg gatgtctggt ggggcggagc agacacagac      180

tatgcagatg ggag                                                        194


<210>  492
<211>  203
<212>  DNA
<213>  Homo sapiens

<400>  492
tgaagacaaa gtagtagaag tagcagagga ggaagaagtg gctgaggtgg aagaagaaga       60

agccgatgat gacgaggacg atgaggatgg tgatgaggta gaggaagagg ctgaggaacc      120

ctacgaagaa gccacagaga gaaccaccag cattgccacc accaccacca ccaccacaga      180

gtctgtggaa gaggtggttc gag                                              203


<210>  493
<211>  168
<212>  DNA
<213>  Homo sapiens

<400>  493
aggtgtgctc tgaacaagcc gagacggggc cgtgccgagc aatgatctcc cgctggtact       60

ttgatgtgac tgaagggaag tgtgccccat tcttttacgg cggatgtggc ggcaaccgga      120

acaactttga cacagaagag tactgcatgg ccgtgtgtgg cagcgcca                   168


<210>  494
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  494
tgtcccaaag tttactcaag actacccagg aacctcttgc ccgagatcct gttaaac          57


<210>  495
<211>  134
<212>  DNA
<213>  Homo sapiens

<400>  495
ttcctacaac agcagccagt acccctgatg ccgttgacaa gtatctcgag acacctgggg       60

atgagaatga acatgcccat ttccagaaag ccaaagagag gcttgaggcc aagcaccgag      120

agagaatgtc ccag                                                        134


<210>  496
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  496
gtcatgagag aatgggaaga ggcagaacgt caagcaaaga acttgcctaa agctgataag       60

aaggcagtta tccag                                                        75


<210>  497
<211>  159
<212>  DNA
<213>  Homo sapiens

<400>  497
catttccagg agaaagtgga atctttggaa caggaagcag ccaacgagag acagcagctg       60

gtggagacac acatggccag agtggaagcc atgctcaatg accgccgccg cctggccctg      120

gagaactaca tcaccgctct gcaggctgtt cctcctcgg                             159


<210>  498
<211>  129
<212>  DNA
<213>  Homo sapiens

<400>  498
cctcgtcacg tgttcaatat gctaaagaag tatgtccgcg cagaacagaa ggacagacag       60

cacaccctaa agcatttcga gcatgtgcgc atggtggatc ccaagaaagc cgctcagatc      120

cggtcccag                                                              129


<210>  499
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  499
gttatgacac acctccgtgt gatttatgag cgcatgaatc agtctctctc cctgctctac       60

aacgtgcctg cagtggccga ggagattcag gatgaagttg                            100


<210>  500
<211>  222
<212>  DNA
<213>  Homo sapiens

<400>  500
atgagctgct tcagaaagag caaaactatt cagatgacgt cttggccaac atgattagtg       60

aaccaaggat cagttacgga aacgatgctc tcatgccatc tttgaccgaa acgaaaacca      120

ccgtggagct ccttcccgtg aatggagagt tcagcctgga cgatctccag ccgtggcatt      180

cttttggggc tgactctgtg ccagccaaca cagaaaacga ag                         222


<210>  501
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  501
ttgagcctgt tgatgcccgc cctgctgccg accgaggact gaccactcga ccag             54


<210>  502
<211>  101
<212>  DNA
<213>  Homo sapiens

<400>  502
gttctgggtt gacaaatatc aagacggagg agatctctga agtgaagatg gatgcagaat       60

tccgacatga ctcaggatat gaagttcatc atcaaaaatt g                          101


<210>  503
<211>  147
<212>  DNA
<213>  Homo sapiens

<400>  503
gtgttctttg cagaagatgt gggttcaaac aaaggtgcaa tcattggact catggtgggc       60

ggtgttgtca tagcgacagt gatcgtcatc accttggtga tgctgaagaa gaaacagtac      120

acatccattc atcatggtgt ggtggag                                          147


<210>  504
<211>  1222
<212>  DNA
<213>  Homo sapiens

<400>  504
gttgacgccg ctgtcacccc agaggagcgc cacctgtcca agatgcagca gaacggctac       60

gaaaatccaa cctacaagtt ctttgagcag atgcagaact agacccccgc cacagcagcc      120

tctgaagttg gacagcaaaa ccattgcttc actacccatc ggtgtccatt tatagaataa      180

tgtgggaaga aacaaacccg ttttatgatt tactcattat cgccttttga cagctgtgct      240

gtaacacaag tagatgcctg aacttgaatt aatccacaca tcagtaatgt attctatctc      300

tctttacatt ttggtctcta tactacatta ttaatgggtt ttgtgtactg taaagaattt      360

agctgtatca aactagtgca tgaatagatt ctctcctgat tatttatcac atagcccctt      420

agccagttgt atattattct tgtggtttgt gacccaatta agtcctactt tacatatgct      480

ttaagaatcg atgggggatg cttcatgtga acgtgggagt tcagctgctt ctcttgccta      540

agtattcctt tcctgatcac tatgcatttt aaagttaaac atttttaagt atttcagatg      600

ctttagagag attttttttc catgactgca ttttactgta cagattgctg cttctgctat      660

atttgtgata taggaattaa gaggatacac acgtttgttt cttcgtgcct gttttatgtg      720

cacacattag gcattgagac ttcaagcttt tctttttttg tccacgtatc tttgggtctt      780

tgataaagaa aagaatccct gttcattgta agcactttta cggggcgggt ggggaggggt      840

gctctgctgg tcttcaatta ccaagaattc tccaaaacaa ttttctgcag gatgattgta      900

cagaatcatt gcttatgaca tgatcgcttt ctacactgta ttacataaat aaattaaata      960

aaataacccc gggcaagact tttctttgaa ggatgactac agacattaaa taatcgaagt     1020

aattttgggt ggggagaaga ggcagattca attttcttta accagtctga agtttcattt     1080

atgatacaaa agaagatgaa aatggaagtg gcaatataag gggatgagga aggcatgcct     1140

ggacaaaccc ttcttttaag atgtgtcttc aatttgtata aaatggtgtt ttcatgtaaa     1200

taaatacatt cttggaggag ca                                              1222


<210>  505
<211>  3415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of APP

<400>  505
gtcagtttcc tcggcagcgg taggcgagag cacgcggagg agcgtgcgcg ggggccccgg       60

gagacggcgg cggtggcggc gcgggcagag caaggacgcg gcggatccca ctcgcacagc      120

agcgcactcg gtgccccgcg cagggtcgcg atgctgcccg gtttggcact gctcctgctg      180

gccgcctgga cggctcgggc gctggaggtc taccctgaac tgcagatcac caatgtggta      240

gaagccaacc aaccagtgac catccagaac tggtgcaagc ggggccgcaa gcagtgcaag      300

acccatcccc actttgtgat tccctaccgc tgcttagttg gtgagtttgt aagtgatgcc      360

cttctcgttc ctgacaagtg caaattctta caccaggaga ggatggatgt ttgcgaaact      420

catcttcact ggcacaccgt cgccaaagag acatgcagtg agaagagtac caacttgcat      480

gactacggca tgttgctgcc ctgcggaatt gacaagttcc gaggggtaga gtttgtgtgt      540

tgcccactgg ctgaagaaag tgacaatgtg gattctgctg atgcggagga ggatgactcg      600

gatgtctggt ggggcggagc agacacagac tatgcagatg ggagtgaaga caaagtagta      660

gaagtagcag aggaggaaga agtggctgag gtggaagaag aagaagccga tgatgacgag      720

gacgatgagg atggtgatga ggtagaggaa gaggctgagg aaccctacga agaagccaca      780

gagagaacca ccagcattgc caccaccacc accaccacca cagagtctgt ggaagaggtg      840

gttcgagagg tgtgctctga acaagccgag acggggccgt gccgagcaat gatctcccgc      900

tggtactttg atgtgactga agggaagtgt gccccattct tttacggcgg atgtggcggc      960

aaccggaaca actttgacac agaagagtac tgcatggccg tgtgtggcag cgccatgtcc     1020

caaagtttac tcaagactac ccaggaacct cttgcccgag atcctgttaa acttcctaca     1080

acagcagcca gtacccctga tgccgttgac aagtatctcg agacacctgg ggatgagaat     1140

gaacatgccc atttccagaa agccaaagag aggcttgagg ccaagcaccg agagagaatg     1200

tcccaggtca tgagagaatg ggaagaggca gaacgtcaag caaagaactt gcctaaagct     1260

gataagaagg cagttatcca gcatttccag gagaaagtgg aatctttgga acaggaagca     1320

gccaacgaga gacagcagct ggtggagaca cacatggcca gagtggaagc catgctcaat     1380

gaccgccgcc gcctggccct ggagaactac atcaccgctc tgcaggctgt tcctcctcgg     1440

cctcgtcacg tgttcaatat gctaaagaag tatgtccgcg cagaacagaa ggacagacag     1500

cacaccctaa agcatttcga gcatgtgcgc atggtggatc ccaagaaagc cgctcagatc     1560

cggtcccagg ttatgacaca cctccgtgtg atttatgagc gcatgaatca gtctctctcc     1620

ctgctctaca acgtgcctgc agtggccgag gagattcagg atgaagttga tgagctgctt     1680

cagaaagagc aaaactattc agatgacgtc ttggccaaca tgattagtga accaaggatc     1740

agttacggaa acgatgctct catgccatct ttgaccgaaa cgaaaaccac cgtggagctc     1800

cttcccgtga atggagagtt cagcctggac gatctccagc cgtggcattc ttttggggct     1860

gactctgtgc cagccaacac agaaaacgaa gttgagcctg ttgatgcccg ccctgctgcc     1920

gaccgaggac tgaccactcg accaggttct gggttgacaa atatcaagac ggaggagatc     1980

tctgaagtga agatggatgc agaattccga catgactcag gatatgaagt tcatcatcaa     2040

aaattggtgt tctttgcaga agatgtgggt tcaaacaaag gtgcaatcat tggactcatg     2100

gtgggcggtg ttgtcatagc gacagtgatc gtcatcacct tggtgatgct gaagaagaaa     2160

cagtacacat ccattcatca tggtgtggtg gaggttgacg ccgctgtcac cccagaggag     2220

cgccacctgt ccaagatgca gcagaacggc tacgaaaatc caacctacaa gttctttgag     2280

cagatgcaga actagacccc cgccacagca gcctctgaag ttggacagca aaaccattgc     2340

ttcactaccc atcggtgtcc atttatagaa taatgtggga agaaacaaac ccgttttatg     2400

atttactcat tatcgccttt tgacagctgt gctgtaacac aagtagatgc ctgaacttga     2460

attaatccac acatcagtaa tgtattctat ctctctttac attttggtct ctatactaca     2520

ttattaatgg gttttgtgta ctgtaaagaa tttagctgta tcaaactagt gcatgaatag     2580

attctctcct gattatttat cacatagccc cttagccagt tgtatattat tcttgtggtt     2640

tgtgacccaa ttaagtccta ctttacatat gctttaagaa tcgatggggg atgcttcatg     2700

tgaacgtggg agttcagctg cttctcttgc ctaagtattc ctttcctgat cactatgcat     2760

tttaaagtta aacattttta agtatttcag atgctttaga gagatttttt ttccatgact     2820

gcattttact gtacagattg ctgcttctgc tatatttgtg atataggaat taagaggata     2880

cacacgtttg tttcttcgtg cctgttttat gtgcacacat taggcattga gacttcaagc     2940

ttttcttttt ttgtccacgt atctttgggt ctttgataaa gaaaagaatc cctgttcatt     3000

gtaagcactt ttacggggcg ggtggggagg ggtgctctgc tggtcttcaa ttaccaagaa     3060

ttctccaaaa caattttctg caggatgatt gtacagaatc attgcttatg acatgatcgc     3120

tttctacact gtattacata aataaattaa ataaaataac cccgggcaag acttttcttt     3180

gaaggatgac tacagacatt aaataatcga agtaattttg ggtggggaga agaggcagat     3240

tcaattttct ttaaccagtc tgaagtttca tttatgatac aaaagaagat gaaaatggaa     3300

gtggcaatat aaggggatga ggaaggcatg cctggacaaa cccttctttt aagatgtgtc     3360

ttcaatttgt ataaaatggt gttttcatgt aaataaatac attcttggag gagca          3415


<210>  506
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  506

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu 
            


<210>  507
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  507

Val Tyr Pro Glu Leu Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro 
1               5                   10                  15      


Val Thr Ile Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr 
            20                  25                  30          


His Pro His Phe Val Ile Pro Tyr Arg Cys Leu 
        35                  40              


<210>  508
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  508

Gly Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys Lys Phe 
1               5                   10                  15      


Leu His Gln Glu Arg Met Asp Val Cys Glu Thr His Leu His Trp His 
            20                  25                  30          


Thr Val Ala Lys Glu 
        35          


<210>  509
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  509

Thr Cys Ser Glu Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu 
1               5                   10                  15      


Pro Cys Gly Ile Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro 
            20                  25                  30          


Leu Ala Glu Glu Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp 
        35                  40                  45              


Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly 
    50                  55                  60                  


<210>  510
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  510

Glu Asp Lys Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val 
1               5                   10                  15      


Glu Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu 
            20                  25                  30          


Val Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr 
        35                  40                  45              


Thr Ser Ile Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu 
    50                  55                  60                  


Val Val Arg 
65          


<210>  511
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  511

Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile Ser 
1               5                   10                  15      


Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe Tyr 
            20                  25                  30          


Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr Cys 
        35                  40                  45              


Met Ala Val Cys Gly Ser Ala 
    50                  55  


<210>  512
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  512

Ser Gln Ser Leu Leu Lys Thr Thr Gln Glu Pro Leu Ala Arg Asp Pro 
1               5                   10                  15      


Val Lys 
        


<210>  513
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  513

Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu 
1               5                   10                  15      


Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu 
            20                  25                  30          


Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln 
        35                  40                  


<210>  514
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  514

Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro 
1               5                   10                  15      


Lys Ala Asp Lys Lys Ala Val Ile Gln 
            20                  25  


<210>  515
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  515

His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu 
1               5                   10                  15      


Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu 
            20                  25                  30          


Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln 
        35                  40                  45              


Ala Val Pro Pro Arg 
    50              


<210>  516
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  516

Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln 
1               5                   10                  15      


Lys Asp Arg Gln His Thr Leu Lys His Phe Glu His Val Arg Met Val 
            20                  25                  30          


Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln 
        35                  40              


<210>  517
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  517

Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu 
1               5                   10                  15      


Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu 
            20                  25                  30          


Val 
    


<210>  518
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  518

Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn 
1               5                   10                  15      


Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro 
            20                  25                  30          


Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly 
        35                  40                  45              


Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp 
    50                  55                  60                  


Ser Val Pro Ala Asn Thr Glu Asn Glu 
65                  70              


<210>  519
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  519

Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg 
1               5                   10                  15      


Pro 
    


<210>  520
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  520

Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met 
1               5                   10                  15      


Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
            20                  25                  30          


Leu 
    


<210>  521
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  521

Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
1               5                   10                  15      


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
            20                  25                  30          


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
        35                  40                  45              


Glu 
    


<210>  522
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  522

Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln 
1               5                   10                  15      


Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln 
            20                  25                  30          


Asn 
    


<210>  523
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  523

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Tyr Pro Glu Leu Gln Ile Thr Asn Val Val Glu Ala 
            20                  25                  30          


Asn Gln Pro Val Thr Ile Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln 
        35                  40                  45              


Cys Lys Thr His Pro His Phe Val Ile Pro Tyr Arg Cys Leu Val Gly 
    50                  55                  60                  


Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys Lys Phe Leu 
65                  70                  75                  80  


His Gln Glu Arg Met Asp Val Cys Glu Thr His Leu His Trp His Thr 
                85                  90                  95      


Val Ala Lys Glu Thr Cys Ser Glu Lys Ser Thr Asn Leu His Asp Tyr 
            100                 105                 110         


Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe Arg Gly Val Glu Phe 
        115                 120                 125             


Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn Val Asp Ser Ala Asp 
    130                 135                 140                 


Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Thr Asp 
145                 150                 155                 160 


Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu Val Ala Glu Glu Glu 
                165                 170                 175     


Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu 
        195                 200                 205             


Ala Thr Glu Arg Thr Thr Ser Ile Ala Thr Thr Thr Thr Thr Thr Thr 
    210                 215                 220                 


Glu Ser Val Glu Glu Val Val Arg Glu Val Cys Ser Glu Gln Ala Glu 
225                 230                 235                 240 


Thr Gly Pro Cys Arg Ala Met Ile Ser Arg Trp Tyr Phe Asp Val Thr 
                245                 250                 255     


Glu Gly Lys Cys Ala Pro Phe Phe Tyr Gly Gly Cys Gly Gly Asn Arg 
            260                 265                 270         


Asn Asn Phe Asp Thr Glu Glu Tyr Cys Met Ala Val Cys Gly Ser Ala 
        275                 280                 285             


Met Ser Gln Ser Leu Leu Lys Thr Thr Gln Glu Pro Leu Ala Arg Asp 
    290                 295                 300                 


Pro Val Lys Leu Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp 
305                 310                 315                 320 


Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln 
                325                 330                 335     


Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln 
            340                 345                 350         


Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro 
        355                 360                 365             


Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu 
    370                 375                 380                 


Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr 
385                 390                 395                 400 


His Met Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala 
                405                 410                 415     


Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg 
            420                 425                 430         


His Val Phe Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp 
        435                 440                 445             


Arg Gln His Thr Leu Lys His Phe Glu His Val Arg Met Val Asp Pro 
    450                 455                 460                 


Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val 
465                 470                 475                 480 


Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro 
                485                 490                 495     


Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys 
            500                 505                 510         


Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro 
        515                 520                 525             


Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr 
    530                 535                 540                 


Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp 
545                 550                 555                 560 


Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn 
                565                 570                 575     


Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg 
            580                 585                 590         


Gly Leu Thr Thr Arg Pro Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu 
        595                 600                 605             


Glu Ile Ser Glu Val Lys Met Asp Ala Glu Phe Arg His Asp Ser Gly 
    610                 615                 620                 


Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly 
625                 630                 635                 640 


Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile 
                645                 650                 655     


Ala Thr Val Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln Tyr 
            660                 665                 670         


Thr Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr Pro 
        675                 680                 685             


Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn Pro 
    690                 695                 700                 


Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
705                 710                 


<210>  524
<211>  1945
<212>  DNA
<213>  Homo sapiens

<400>  524
gtcagtttcc tcggcagcgg taggcgagag cacgcggagg agcgtgcgcg ggggccccgg       60

gagacggcgg cggtggcggc gcgggcagag caaggacgcg gcggatccca ctcgcacagc      120

agcgcactcg gtgccccgcg cagggtcgcg atgctgcccg gtttggcact gctcctgctg      180

gccgcctgga cggctcgggc gctggaggtc taccctgaac tgcagatcac caatgtggta      240

gaagccaacc aaccagtgac catccagaac tggtgcaagc ggggccgcaa gcagtgcaag      300

acccatcccc actttgtgat tccctaccgc tgcttagttg gtgagtttgt aagtgatgcc      360

cttctcgttc ctgacaagtg caaattctta caccaggaga ggatggatgt ttgcgaaact      420

catcttcact ggcacaccgt cgccaaagag acatgcagtg agaagagtac caacttgcat      480

gactacggca tgttgctgcc ctgcggaatt gacaagttcc gaggggtaga gtttgtgtgt      540

tgcccactgg ctgaagaaag tgacaatgtg gattctgctg atgcggagga ggatgactcg      600

gatgtctggt ggggcggagc agacacagac tatgcagatg ggagtgaaga caaagtagta      660

gaagtagcag aggaggaaga agtggctgag gtggaagaag aagaagccga tgatgacgag      720

gacgatgagg atggtgatga ggtagaggaa gaggctgagg aaccctacga agaagccaca      780

gagagaacca ccagcattgc caccaccacc accaccacca cagagtctgt ggaagaggtg      840

gttcgagagg tgtgctctga acaagccgag acggggccgt gccgagcaat gatctcccgc      900

tggtactttg atgtgactga agggaagtgt gccccattct tttacggcgg atgtggcggc      960

aaccggaaca actttgacac agaagagtac tgcatggccg tgtgtggcag cgccatgtcc     1020

caaagtttac tcaagactac ccaggaacct cttgcccgag atcctgttaa acttcctaca     1080

acagcagcca gtacccctga tgccgttgac aagtatctcg agacacctgg ggatgagaat     1140

gaacatgccc atttccagaa agccaaagag aggcttgagg ccaagcaccg agagagaatg     1200

tcccaggtca tgagagaatg ggaagaggca gaacgtcaag caaagaactt gcctaaagct     1260

gataagaagg cagttatcca gcatttccag gagaaagtgg aatctttgga acaggaagca     1320

gccaacgaga gacagcagct ggtggagaca cacatggcca gagtggaagc catgctcaat     1380

gaccgccgcc gcctggccct ggagaactac atcaccgctc tgcaggctgt tcctcctcgg     1440

cctcgtcacg tgttcaatat gctaaagaag tatgtccgcg cagaacagaa ggacagacag     1500

cacaccctaa agcatttcga gcatgtgcgc atggtggatc ccaagaaagc cgctcagatc     1560

cggtcccagg ttatgacaca cctccgtgtg atttatgagc gcatgaatca gtctctctcc     1620

ctgctctaca acgtgcctgc agtggccgag gagattcagg atgaagttga tgagctgctt     1680

cagaaagagc aaaactattc agatgacgtc ttggccaaca tgattagtga accaaggatc     1740

agttacggaa acgatgctct catgccatct ttgaccgaaa cgaaaaccac cgtggagctc     1800

cttcccgtga atggagagtt cagcctggac gatctccagc cgtggcattc ttttggggct     1860

gactctgtgc cagccaacac agaaaacgaa gttgagcctg ttgatgcccg ccctgctgcc     1920

gaccgaggac tgaccactcg accag                                           1945


<210>  525
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  525

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Tyr Pro Glu Leu Gln Ile Thr Asn Val Val Glu Ala 
            20                  25                  30          


Asn Gln Pro Val Thr Ile Gln Asn Trp Cys Lys Arg Gly Arg Lys Gln 
        35                  40                  45              


Cys Lys Thr His Pro His Phe Val Ile Pro Tyr Arg Cys Leu Val Gly 
    50                  55                  60                  


Glu Phe Val Ser Asp Ala Leu Leu Val Pro Asp Lys Cys Lys Phe Leu 
65                  70                  75                  80  


His Gln Glu Arg Met Asp Val Cys Glu Thr His Leu His Trp His Thr 
                85                  90                  95      


Val Ala Lys Glu Thr Cys Ser Glu Lys Ser Thr Asn Leu His Asp Tyr 
            100                 105                 110         


Gly Met Leu Leu Pro Cys Gly Ile Asp Lys Phe Arg Gly Val Glu Phe 
        115                 120                 125             


Val Cys Cys Pro Leu Ala Glu Glu Ser Asp Asn Val Asp Ser Ala Asp 
    130                 135                 140                 


Ala Glu Glu Asp Asp Ser Asp Val Trp Trp Gly Gly Ala Asp Thr Asp 
145                 150                 155                 160 


Tyr Ala Asp Gly Ser Glu Asp Lys Val Val Glu Val Ala Glu Glu Glu 
                165                 170                 175     


Glu Val Ala Glu Val Glu Glu Glu Glu Ala Asp Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Gly Asp Glu Val Glu Glu Glu Ala Glu Glu Pro Tyr Glu Glu 
        195                 200                 205             


Ala Thr Glu Arg Thr Thr Ser Ile Ala Thr Thr Thr Thr Thr Thr Thr 
    210                 215                 220                 


Glu Ser Val Glu Glu Val Val Arg Glu Val Cys Ser Glu Gln Ala Glu 
225                 230                 235                 240 


Thr Gly Pro Cys Arg Ala Met Ile Ser Arg Trp Tyr Phe Asp Val Thr 
                245                 250                 255     


Glu Gly Lys Cys Ala Pro Phe Phe Tyr Gly Gly Cys Gly Gly Asn Arg 
            260                 265                 270         


Asn Asn Phe Asp Thr Glu Glu Tyr Cys Met Ala Val Cys Gly Ser Ala 
        275                 280                 285             


Met Ser Gln Ser Leu Leu Lys Thr Thr Gln Glu Pro Leu Ala Arg Asp 
    290                 295                 300                 


Pro Val Lys Leu Pro Thr Thr Ala Ala Ser Thr Pro Asp Ala Val Asp 
305                 310                 315                 320 


Lys Tyr Leu Glu Thr Pro Gly Asp Glu Asn Glu His Ala His Phe Gln 
                325                 330                 335     


Lys Ala Lys Glu Arg Leu Glu Ala Lys His Arg Glu Arg Met Ser Gln 
            340                 345                 350         


Val Met Arg Glu Trp Glu Glu Ala Glu Arg Gln Ala Lys Asn Leu Pro 
        355                 360                 365             


Lys Ala Asp Lys Lys Ala Val Ile Gln His Phe Gln Glu Lys Val Glu 
    370                 375                 380                 


Ser Leu Glu Gln Glu Ala Ala Asn Glu Arg Gln Gln Leu Val Glu Thr 
385                 390                 395                 400 


His Met Ala Arg Val Glu Ala Met Leu Asn Asp Arg Arg Arg Leu Ala 
                405                 410                 415     


Leu Glu Asn Tyr Ile Thr Ala Leu Gln Ala Val Pro Pro Arg Pro Arg 
            420                 425                 430         


His Val Phe Asn Met Leu Lys Lys Tyr Val Arg Ala Glu Gln Lys Asp 
        435                 440                 445             


Arg Gln His Thr Leu Lys His Phe Glu His Val Arg Met Val Asp Pro 
    450                 455                 460                 


Lys Lys Ala Ala Gln Ile Arg Ser Gln Val Met Thr His Leu Arg Val 
465                 470                 475                 480 


Ile Tyr Glu Arg Met Asn Gln Ser Leu Ser Leu Leu Tyr Asn Val Pro 
                485                 490                 495     


Ala Val Ala Glu Glu Ile Gln Asp Glu Val Asp Glu Leu Leu Gln Lys 
            500                 505                 510         


Glu Gln Asn Tyr Ser Asp Asp Val Leu Ala Asn Met Ile Ser Glu Pro 
        515                 520                 525             


Arg Ile Ser Tyr Gly Asn Asp Ala Leu Met Pro Ser Leu Thr Glu Thr 
    530                 535                 540                 


Lys Thr Thr Val Glu Leu Leu Pro Val Asn Gly Glu Phe Ser Leu Asp 
545                 550                 555                 560 


Asp Leu Gln Pro Trp His Ser Phe Gly Ala Asp Ser Val Pro Ala Asn 
                565                 570                 575     


Thr Glu Asn Glu Val Glu Pro Val Asp Ala Arg Pro Ala Ala Asp Arg 
            580                 585                 590         


Gly Leu Thr Thr Arg Pro 
        595             


<210>  526
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  526
aagctggctg cccccttgat ttggagcgag caggcctgac tccagaggtt cagaagatta       60

ttgctgatgt tatccgaaac cctcccgtca actcag                                 96


<210>  527
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  527
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatggaggg gagtgct                                           87


<210>  528
<211>  182
<212>  DNA
<213>  Homo sapiens

<400>  528
aagctggctg cccccttgat ttggagcgag caggcctgac tccagaggtt cagaagatta       60

ttgctgatgt tatccgaaac cctcccgtca actcagctac atctacatcc accactggga      120

caagccatct tgtaaaatgt gcggagaagg agaaaacttt ctgtgtgaat ggaggggagt      180

gc                                                                     182


<210>  529
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  529

Ala Gly Cys Pro Leu Asp Leu Glu Arg Ala Gly Leu Thr Pro Glu Val 
1               5                   10                  15      


Gln Lys Ile Ile Ala Asp Val Ile Arg Asn Pro Pro Val Asn Ser Ala 
            20                  25                  30          


Thr Ser Thr Ser Thr Thr Gly Thr Ser His Leu Val Lys Cys Ala Glu 
        35                  40                  45              


Lys Glu Lys Thr Phe Cys Val Asn Gly Gly Glu Cys 
    50                  55                  60  


<210>  530
<211>  164
<212>  DNA
<213>  Homo sapiens

<400>  530
gtgtactgtg tgcgccgggg aggcgccggc ttgtactcgg cagcgcggga ataaagtttg       60

ctgatttggt gtctagcctg gatgcctggg ttgcaggccc tgcttgtggt ggcgctccac      120

agtcatccgg ctgaagaaga cctgttggac tggatcttct cggg                       164


<210>  531
<211>  172
<212>  DNA
<213>  Homo sapiens

<400>  531
ttttctttca gatattgttt tgtatttacc catgaagaca ttgttttttg gactctgcaa       60

ataggacatt tcaaagatga gtgaaaaaaa attggaaaca actgcacagc agcggaaatg      120

tcctgaatgg atgaatgtgc agaataaaag atgtgctgta gaagaaagaa ag              172


<210>  532
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  532
gcatgtgttc ggaagagtgt ttttgaagat gacctcccct tcttagaatt cactggatcc       60

attgtgtata gttacgatgc tagtgattgc tctttcctgt cagaagatat tag             113


<210>  533
<211>  146
<212>  DNA
<213>  Homo sapiens

<400>  533
catgagtcta tcagatgggg atgtggtggg atttgacatg gagtggccac cattatacaa       60

tagagggaaa cttggcaaag ttgcactaat tcagttgtgt gtttctgaga gcaaatgtta      120

cttgttccac gtttcttcca tgtcag                                           146


<210>  534
<211>  149
<212>  DNA
<213>  Homo sapiens

<400>  534
tttttcccca gggattaaaa atgttgcttg aaaataaagc agttaaaaag gcaggtgtag       60

gaattgaagg agatcagtgg aaacttctac gtgactttga tatcaaattg aagaattttg      120

tggagttgac agatgttgcc aataaaaag                                        149


<210>  535
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  535
ctgaaatgca cagagacctg gagccttaac agtctggtta aacacctctt aggtaaacag       60

ctcctgaaag acaagtctat ccgctgtagc aattggagta aatttcctct cactgaggac      120

cagaaactgt atgcagccac tgatgcttat                                       150


<210>  536
<211>  70
<212>  DNA
<213>  Homo sapiens

<400>  536
gctggtttta ttatttaccg aaatttagag attttggatg atactgtgca aaggtttgct       60

ataaataaag                                                              70


<210>  537
<211>  115
<212>  DNA
<213>  Homo sapiens

<400>  537
aggaagaaat cctacttagc gacatgaaca aacagttgac ttcaatctct gaggaagtga       60

tggatctggc taagcatctt cctcatgctt tcagtaaatt ggaaaaccca cggag           115


<210>  538
<211>  430
<212>  DNA
<213>  Homo sapiens

<400>  538
ggtttctatc ttactaaagg atatttcaga aaatctatat tcactgagga ggatgataat       60

tgggtctact aacattgaga ctgaactgag gcccagcaat aatttaaact tattatcctt      120

tgaagattca actactgggg gagtacaaca gaaacaaatt agagaacatg aagttttaat      180

tcacgttgaa gatgaaacat gggacccaac acttgatcat ttagctaaac atgatggaga      240

agatgtactt ggaaataaag tggaacgaaa agaagatgga tttgaagatg gagtagaaga      300

caacaaattg aaagagaata tggaaagagc ttgtttgatg tcgttagata ttacagaaca      360

tgaactccaa attttggaac agcagtctca ggaagaatat cttagtgata ttgcttataa      420

atctactgag                                                             430


<210>  539
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  539
catttatctc ccaatgataa tgaaaacgat acgtcctatg taattgagag tgatgaagat       60

ttagaaatgg agatgcttaa g                                                 81


<210>  540
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  540
catttatctc ccaatgataa tgaaaacgat acgtcctatg taattgagag tgatgaagat       60

ttagaaatgg agatgcttaa g                                                 81


<210>  541
<211>  145
<212>  DNA
<213>  Homo sapiens

<400>  541
tctttagaaa acctcaatag tggcacggta gaaccaactc attctaaatg cttaaaaatg       60

gaaagaaatc tgggtcttcc tactaaagaa gaagaagaag atgatgaaaa tgaagctaat      120

gaaggggaag aagatgatga taagg                                            145


<210>  542
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  542
actttttgtg gccagcaccc aatgaagagc aagttacttg cctcaagatg tactttggcc       60

attccagttt taaacc                                                       76


<210>  543
<211>  68
<212>  DNA
<213>  Homo sapiens

<400>  543
agttcagtgg aaagtgattc attcagtatt agaagaaaga agagataatg ttgctgtcat       60

ggcaactg                                                                68


<210>  544
<211>  109
<212>  DNA
<213>  Homo sapiens

<400>  544
gatatggaaa gagtttgtgc ttccagtatc cacctgttta tgtaggcaag attggccttg       60

ttatctctcc ccttatttct ctgatggaag accaagtgct acagcttaa                  109


<210>  545
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  545
aatgtccaac atcccagctt gcttccttgg atcagcacag tcagaaaatg ttctaacaga       60

tattaaatt                                                               69


<210>  546
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  546
aggtaaatac cggattgtat acgtaactcc agaatactgt tcaggtaaca tgggcctgct       60

ccagcaactt gaggctgata ttg                                               83


<210>  547
<211>  107
<212>  DNA
<213>  Homo sapiens

<400>  547
gtatcacgct cattgctgtg gatgaggctc actgtatttc tgagtggggg catgatttta       60

gggattcatt caggaagttg ggctccctaa agacagcact gccaatg                    107


<210>  548
<211>  185
<212>  DNA
<213>  Homo sapiens

<400>  548
gttccaatcg ttgcacttac tgctactgca agttcttcaa tccgggaaga cattgtacgt       60

tgcttaaatc tgagaaatcc tcagatcacc tgtactggtt ttgatcgacc aaacctgtat      120

ttagaagtta ggcgaaaaac agggaatatc cttcaggatc tgcagccatt tcttgtcaaa      180

acaag                                                                  185


<210>  549
<211>  175
<212>  DNA
<213>  Homo sapiens

<400>  549
ttcccactgg gaatttgaag gtccaacaat catctactgt ccttctagaa aaatgacaca       60

acaagttaca ggtgaactta ggaaactgaa tctatcctgt ggaacatacc atgcgggcat      120

gagttttagc acaaggaaag acattcatca taggtttgta agagatgaaa ttcag           175


<210>  550
<211>  182
<212>  DNA
<213>  Homo sapiens

<400>  550
tgtgtcatag ctaccatagc ttttggaatg ggcattaata aagctgacat tcgccaagtc       60

attcattacg gtgctcctaa ggacatggaa tcatattatc aggagattgg tagagctggt      120

cgtgatggac ttcaaagttc ttgtcacgtc ctctgggctc ctgcagacat taacttaaat      180

ag                                                                     182


<210>  551
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  551
gcaccttctt actgagatac gtaatgagaa gtttcgatta tacaaattaa agatgatggc       60

aaagatggaa aaatatcttc attctagcag atgtaggaga ca                         102


<210>  552
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  552
aatcatcttg tctcattttg aggacaaaca agtacaaaaa gcctccttgg gaattatggg       60

aactgaaaaa tgctgtgata attgcaggtc cag                                    93


<210>  553
<211>  142
<212>  DNA
<213>  Homo sapiens

<400>  553
attggatcat tgctattcca tggatgactc agaggataca tcctgggact ttggtccaca       60

agcatttaag cttttgtctg ctgtggacat cttaggcgaa aaatttggaa ttgggcttcc      120

aattttattt ctccgaggat ct                                               142


<210>  554
<211>  171
<212>  DNA
<213>  Homo sapiens

<400>  554
aattctcagc gtcttgccga tcaatatcgc aggcacagtt tatttggcac tggcaaggat       60

caaacagaga gttggtggaa ggctttttcc cgtcagctga tcactgaggg attcttggta      120

gaagtttctc ggtataacaa atttatgaag atttgcgccc ttacgaaaaa g               171


<210>  555
<211>  95
<212>  DNA
<213>  Homo sapiens

<400>  555
ggtagaaatt ggcttcataa agctaataca gaatctcaga gcctcatcct tcaagctaat       60

gaagaattgt gtccaaagaa gttgcttctg cctag                                  95


<210>  556
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  556
ttcgaaaact gtatcttcgg gcaccaaaga gcattgttat aatcaagtac cagttgaatt       60

aagtacagag aagaag                                                       76


<210>  557
<211>  74
<212>  DNA
<213>  Homo sapiens

<400>  557
tctaacttgg agaagttata ttcttataaa ccatgtgata agatttcttc tgggagtaac       60

atttctaaaa aaag                                                         74


<210>  558
<211>  76
<212>  DNA
<213>  Homo sapiens

<400>  558
tatcatggta cagtcaccag aaaaagctta cagttcctca cagcctgtta tttcggcaca       60

agagcaggag actcag                                                       76


<210>  559
<211>  113
<212>  DNA
<213>  Homo sapiens

<400>  559
attgtgttat atggcaaatt ggtagaagct aggcagaaac atgccaataa aatggatgtt       60

cccccagcta ttctggcaac aaacaagata ctggtggata tggccaaaat gag             113


<210>  560
<211>  115
<212>  DNA
<213>  Homo sapiens

<400>  560
accaactacg gttgaaaacg taaaaaggat tgatggtgtt tctgaaggca aagctgccat       60

gttggcccct ctgttggaag tcatcaaaca tttctgccaa acaaatagtg ttcag           115


<210>  561
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  561
acagacctct tttcaagtac aaaacctcaa gaagaacaga agacgagtct ggtagcaaaa       60

aataaaatat gcacactttc acagtctatg gccatcacat actctttatt ccaagaaaag      120

aagatgcctt tg                                                          132


<210>  562
<211>  163
<212>  DNA
<213>  Homo sapiens

<400>  562
aagagcatag ctgagagcag gattctgcct ctcatgacaa ttggcatgca cttatcccaa       60

gcggtgaaag ctggctgccc ccttgatttg gagcgagcag gcctgactcc agaggttcag      120

aagattattg ctgatgttat ccgaaaccct cccgtcaact cag                        163


<210>  563
<211>  209
<212>  DNA
<213>  Homo sapiens

<400>  563
atatgagtaa aattagccta atcagaatgt tagttcctga aaacattgac acgtacctta       60

tccacatggc aattgagatc cttaaacatg gtcctgacag cggacttcaa ccttcatgtg      120

atgtcaacaa aaggagatgt tttcccggtt ctgaagagat ctgttcaagt tctaagagaa      180

gcaaggaaga agtaggcatc aatactgag                                        209


<210>  564
<211>  3144
<212>  DNA
<213>  Homo sapiens

<400>  564
acttcatctg cagagagaaa gagacgatta cctgtgtggt ttgccaaagg aagtgatacc       60

agcaagaaat taatggacaa aacgaaaagg ggaggtcttt ttagttaagc tggcaattac      120

cagaacaatt atgtttcttg ctgtattata agaggatagc tatattttat ttctgaagag      180

taaggagtag tattttggct taaaaatcat tctaattaca aagttcactg tttattgaag      240

aactggcatc ttaaatcagc cttccgcaat tcatgtagtt tctgggtctt ctgggagcct      300

acgtgagtac atcacctaac agaatattaa attagacttc ctgtaagatt gctttaagaa      360

actgttactg tcctgttttc taatctcttt attaaaacag tgtatttgga aaatgttatg      420

tgctctgatt tgatatagat aacagattag tagttacatg gtaattatgt gatataaaat      480

attcatatat tatcaaaatt ctgttttgta aatgtaagaa agcatagtta ttttacaaat      540

tgtttttact gtcttttgaa gaagttctta aatacgttgt taaatggtat tagttgacca      600

gggcagtgaa aatgaaaccg cattttgggt gccattaaat agggaaaaaa catgtaaaaa      660

atgtaaaatg gagaccaatt gcactaggca agtgtatatt ttgtatttta tatacaattt      720

ctattatttt tcaagtaata aaacaatgtt tttcatactg aatattatat atatattttt      780

tagctttcat ttacttaatt attttaagta cctttatttt tccaggatgt cagaatttga      840

ttctaatctc tcttatgtag cacatgtgac ttaatttaaa acctatactg tgacacagag      900

ttgggtaaac gatgattatt taactttaag cagttcacca tccatttcaa agcctttgat      960

tggctttttt gtaaataaaa ataacttgtt aagaaacaaa tatatctgtc atagaagaac     1020

tagaaaatcc agggaagtga gaaaaatgaa aataaaaatc attcatagtt ttactagtag     1080

ctaatcacag tcaacctctt ttgtgtatcc caccagactt ttttatattc atttgttttt     1140

agttaaaata taaaagtctc gtatattccc atttttctgc attgcattac cagaaggtag     1200

tggcgcctat taaatatgtg atatgttgtt gtccagccat ggcttctgca tttgcatgct     1260

tttgtgtgtg catctgcaat accctgtgaa tatcctgtgt gatggagtgg caagtacgca     1320

cagacacgtc tgctgcatgc ctaggtacga ggctgtctcc aggagaagca cttgtttgat     1380

tatttgagtt gccaattgaa tttgctgctt tttttcatgg cttgccattt tcactgaaaa     1440

gaatgactaa tgaaaaacga tgattggtta ttagatttgg atgtttggca gacattttct     1500

caaaattgaa ctaagttggc ctcttcacgg aaaacaactg gtatttgttg tgccaatgat     1560

aaaattggag atttctagca aaatgtataa ttttggaaaa gttgtgttcc tccactggaa     1620

gcttgacagc tttccttaac ataaagactt ctctttctct tcgctttcac tactactact     1680

actaattctt cttctgattc ttcttcttct ccttcttcct tcttccttcc ttcctcctcc     1740

tcctccttct tcttcctctt cctcttcttc tttctctctt tccttccttc ccttcccttc     1800

cccttccttc cttccttcct tccttcctcc ctccctccct ccctccctcc ctccctcctt     1860

tctttttctt tctctttctt tctttctttc tctctctctc tctctttctt tctttttctt     1920

tctctttttc tttctttcaa gcagtcctcc cgcctcagtc ccccaaaata gtgggattac     1980

aggtgtgagc caccatgcac agccttacat aaagcctttt ctaatgagat ggatagtaat     2040

taacaaatgt gagtttttga tattatataa agattttttc tgtgtttcga agatccgtat     2100

aactcagtga atcagtatgt tctggatgac taatatgtga tgttaagaaa tcatgactga     2160

ggccgggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggccga ggcgggcgga     2220

tcacgagatc aggagatcga gaccaccctg gccaacatgg tgaaaccccg tctctactaa     2280

aaatacaaaa attagctggg tgtgttggtg cgtgcctata atcccagcta ctcgggaggc     2340

tgaggcagga gaatcgcttg aactcaggag gcggagattg cagtgagctg agactgcgcc     2400

actgcacccc agcctggcga cagagcaaga ctccgtctca aaaataaaaa aagaaatcat     2460

gactgggtaa aagatctgtt cagagtacaa gatggaccaa tggatttgat atatttgaat     2520

ataacagagt atgaaaaagt ttattgatat agtttcagat tacacactgc aactaatctt     2580

taagaaacta ttacttgtcc actttttggt aaaatttcag agaacaatgt ccaccattat     2640

ctgaacaggc tattaaaata ctcttctctt ttccaactac gtgcctgtgc aaagtcagat     2700

ttttttcata tacttcagcc aaaacagcat atcaaaatgg attgaatgca gaagtagatc     2760

tgagaataca gccacttttg ttaagccaga caatgagatt tgcaaaatgt aaacaatgct     2820

gctgttctca gtttttaaaa atatgttttt taaaagtatt tatgttaatg tgtacttggt     2880

ttactactgc tatttttaaa taaaacaaga aacattttta aatgtctgtt ttaatttcta     2940

aagtggtagt gatagatata acccatatta ataaaagctc tttggggtcc tcagtgattt     3000

ttttttaaga gtatggaagg gttctcagac ctaagagatt gagaaatgct gatgtaatgt     3060

tttattataa aggtgtacca tgaattatgt accttacttc atattgttgg acattaaagt     3120

tgctttcagt ttttttgttt taaa                                            3144


<210>  565
<211>  7575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of WRN

<400>  565
gtgtactgtg tgcgccgggg aggcgccggc ttgtactcgg cagcgcggga ataaagtttg       60

ctgatttggt gtctagcctg gatgcctggg ttgcaggccc tgcttgtggt ggcgctccac      120

agtcatccgg ctgaagaaga cctgttggac tggatcttct cgggttttct ttcagatatt      180

gttttgtatt tacccatgaa gacattgttt tttggactct gcaaatagga catttcaaag      240

atgagtgaaa aaaaattgga aacaactgca cagcagcgga aatgtcctga atggatgaat      300

gtgcagaata aaagatgtgc tgtagaagaa agaaaggcat gtgttcggaa gagtgttttt      360

gaagatgacc tccccttctt agaattcact ggatccattg tgtatagtta cgatgctagt      420

gattgctctt tcctgtcaga agatattagc atgagtctat cagatgggga tgtggtggga      480

tttgacatgg agtggccacc attatacaat agagggaaac ttggcaaagt tgcactaatt      540

cagttgtgtg tttctgagag caaatgttac ttgttccacg tttcttccat gtcagttttt      600

ccccagggat taaaaatgtt gcttgaaaat aaagcagtta aaaaggcagg tgtaggaatt      660

gaaggagatc agtggaaact tctacgtgac tttgatatca aattgaagaa ttttgtggag      720

ttgacagatg ttgccaataa aaagctgaaa tgcacagaga cctggagcct taacagtctg      780

gttaaacacc tcttaggtaa acagctcctg aaagacaagt ctatccgctg tagcaattgg      840

agtaaatttc ctctcactga ggaccagaaa ctgtatgcag ccactgatgc ttatgctggt      900

tttattattt accgaaattt agagattttg gatgatactg tgcaaaggtt tgctataaat      960

aaagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa     1020

gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg     1080

gtttctatct tactaaagga tatttcagaa aatctatatt cactgaggag gatgataatt     1140

gggtctacta acattgagac tgaactgagg cccagcaata atttaaactt attatccttt     1200

gaagattcaa ctactggggg agtacaacag aaacaaatta gagaacatga agttttaatt     1260

cacgttgaag atgaaacatg ggacccaaca cttgatcatt tagctaaaca tgatggagaa     1320

gatgtacttg gaaataaagt ggaacgaaaa gaagatggat ttgaagatgg agtagaagac     1380

aacaaattga aagagaatat ggaaagagct tgtttgatgt cgttagatat tacagaacat     1440

gaactccaaa ttttggaaca gcagtctcag gaagaatatc ttagtgatat tgcttataaa     1500

tctactgagc atttatctcc caatgataat gaaaacgata cgtcctatgt aattgagagt     1560

gatgaagatt tagaaatgga gatgcttaag catttatctc ccaatgataa tgaaaacgat     1620

acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa gtctttagaa     1680

aacctcaata gtggcacggt agaaccaact cattctaaat gcttaaaaat ggaaagaaat     1740

ctgggtcttc ctactaaaga agaagaagaa gatgatgaaa atgaagctaa tgaaggggaa     1800

gaagatgatg ataaggactt tttgtggcca gcacccaatg aagagcaagt tacttgcctc     1860

aagatgtact ttggccattc cagttttaaa ccagttcagt ggaaagtgat tcattcagta     1920

ttagaagaaa gaagagataa tgttgctgtc atggcaactg gatatggaaa gagtttgtgc     1980

ttccagtatc cacctgttta tgtaggcaag attggccttg ttatctctcc ccttatttct     2040

ctgatggaag accaagtgct acagcttaaa atgtccaaca tcccagcttg cttccttgga     2100

tcagcacagt cagaaaatgt tctaacagat attaaattag gtaaataccg gattgtatac     2160

gtaactccag aatactgttc aggtaacatg ggcctgctcc agcaacttga ggctgatatt     2220

ggtatcacgc tcattgctgt ggatgaggct cactgtattt ctgagtgggg gcatgatttt     2280

agggattcat tcaggaagtt gggctcccta aagacagcac tgccaatggt tccaatcgtt     2340

gcacttactg ctactgcaag ttcttcaatc cgggaagaca ttgtacgttg cttaaatctg     2400

agaaatcctc agatcacctg tactggtttt gatcgaccaa acctgtattt agaagttagg     2460

cgaaaaacag ggaatatcct tcaggatctg cagccatttc ttgtcaaaac aagttcccac     2520

tgggaatttg aaggtccaac aatcatctac tgtccttcta gaaaaatgac acaacaagtt     2580

acaggtgaac ttaggaaact gaatctatcc tgtggaacat accatgcggg catgagtttt     2640

agcacaagga aagacattca tcataggttt gtaagagatg aaattcagtg tgtcatagct     2700

accatagctt ttggaatggg cattaataaa gctgacattc gccaagtcat tcattacggt     2760

gctcctaagg acatggaatc atattatcag gagattggta gagctggtcg tgatggactt     2820

caaagttctt gtcacgtcct ctgggctcct gcagacatta acttaaatag gcaccttctt     2880

actgagatac gtaatgagaa gtttcgatta tacaaattaa agatgatggc aaagatggaa     2940

aaatatcttc attctagcag atgtaggaga caaatcatct tgtctcattt tgaggacaaa     3000

caagtacaaa aagcctcctt gggaattatg ggaactgaaa aatgctgtga taattgcagg     3060

tccagattgg atcattgcta ttccatggat gactcagagg atacatcctg ggactttggt     3120

ccacaagcat ttaagctttt gtctgctgtg gacatcttag gcgaaaaatt tggaattggg     3180

cttccaattt tatttctccg aggatctaat tctcagcgtc ttgccgatca atatcgcagg     3240

cacagtttat ttggcactgg caaggatcaa acagagagtt ggtggaaggc tttttcccgt     3300

cagctgatca ctgagggatt cttggtagaa gtttctcggt ataacaaatt tatgaagatt     3360

tgcgccctta cgaaaaaggg tagaaattgg cttcataaag ctaatacaga atctcagagc     3420

ctcatccttc aagctaatga agaattgtgt ccaaagaagt tgcttctgcc tagttcgaaa     3480

actgtatctt cgggcaccaa agagcattgt tataatcaag taccagttga attaagtaca     3540

gagaagaagt ctaacttgga gaagttatat tcttataaac catgtgataa gatttcttct     3600

gggagtaaca tttctaaaaa aagtatcatg gtacagtcac cagaaaaagc ttacagttcc     3660

tcacagcctg ttatttcggc acaagagcag gagactcaga ttgtgttata tggcaaattg     3720

gtagaagcta ggcagaaaca tgccaataaa atggatgttc ccccagctat tctggcaaca     3780

aacaagatac tggtggatat ggccaaaatg agaccaacta cggttgaaaa cgtaaaaagg     3840

attgatggtg tttctgaagg caaagctgcc atgttggccc ctctgttgga agtcatcaaa     3900

catttctgcc aaacaaatag tgttcagaca gacctctttt caagtacaaa acctcaagaa     3960

gaacagaaga cgagtctggt agcaaaaaat aaaatatgca cactttcaca gtctatggcc     4020

atcacatact ctttattcca agaaaagaag atgcctttga agagcatagc tgagagcagg     4080

attctgcctc tcatgacaat tggcatgcac ttatcccaag cggtgaaagc tggctgcccc     4140

cttgatttgg agcgagcagg cctgactcca gaggttcaga agattattgc tgatgttatc     4200

cgaaaccctc ccgtcaactc agatatgagt aaaattagcc taatcagaat gttagttcct     4260

gaaaacattg acacgtacct tatccacatg gcaattgaga tccttaaaca tggtcctgac     4320

agcggacttc aaccttcatg tgatgtcaac aaaaggagat gttttcccgg ttctgaagag     4380

atctgttcaa gttctaagag aagcaaggaa gaagtaggca tcaatactga gacttcatct     4440

gcagagagaa agagacgatt acctgtgtgg tttgccaaag gaagtgatac cagcaagaaa     4500

ttaatggaca aaacgaaaag gggaggtctt tttagttaag ctggcaatta ccagaacaat     4560

tatgtttctt gctgtattat aagaggatag ctatatttta tttctgaaga gtaaggagta     4620

gtattttggc ttaaaaatca ttctaattac aaagttcact gtttattgaa gaactggcat     4680

cttaaatcag ccttccgcaa ttcatgtagt ttctgggtct tctgggagcc tacgtgagta     4740

catcacctaa cagaatatta aattagactt cctgtaagat tgctttaaga aactgttact     4800

gtcctgtttt ctaatctctt tattaaaaca gtgtatttgg aaaatgttat gtgctctgat     4860

ttgatataga taacagatta gtagttacat ggtaattatg tgatataaaa tattcatata     4920

ttatcaaaat tctgttttgt aaatgtaaga aagcatagtt attttacaaa ttgtttttac     4980

tgtcttttga agaagttctt aaatacgttg ttaaatggta ttagttgacc agggcagtga     5040

aaatgaaacc gcattttggg tgccattaaa tagggaaaaa acatgtaaaa aatgtaaaat     5100

ggagaccaat tgcactaggc aagtgtatat tttgtatttt atatacaatt tctattattt     5160

ttcaagtaat aaaacaatgt ttttcatact gaatattata tatatatttt ttagctttca     5220

tttacttaat tattttaagt acctttattt ttccaggatg tcagaatttg attctaatct     5280

ctcttatgta gcacatgtga cttaatttaa aacctatact gtgacacaga gttgggtaaa     5340

cgatgattat ttaactttaa gcagttcacc atccatttca aagcctttga ttggcttttt     5400

tgtaaataaa aataacttgt taagaaacaa atatatctgt catagaagaa ctagaaaatc     5460

cagggaagtg agaaaaatga aaataaaaat cattcatagt tttactagta gctaatcaca     5520

gtcaacctct tttgtgtatc ccaccagact tttttatatt catttgtttt tagttaaaat     5580

ataaaagtct cgtatattcc catttttctg cattgcatta ccagaaggta gtggcgccta     5640

ttaaatatgt gatatgttgt tgtccagcca tggcttctgc atttgcatgc ttttgtgtgt     5700

gcatctgcaa taccctgtga atatcctgtg tgatggagtg gcaagtacgc acagacacgt     5760

ctgctgcatg cctaggtacg aggctgtctc caggagaagc acttgtttga ttatttgagt     5820

tgccaattga atttgctgct ttttttcatg gcttgccatt ttcactgaaa agaatgacta     5880

atgaaaaacg atgattggtt attagatttg gatgtttggc agacattttc tcaaaattga     5940

actaagttgg cctcttcacg gaaaacaact ggtatttgtt gtgccaatga taaaattgga     6000

gatttctagc aaaatgtata attttggaaa agttgtgttc ctccactgga agcttgacag     6060

ctttccttaa cataaagact tctctttctc ttcgctttca ctactactac tactaattct     6120

tcttctgatt cttcttcttc tccttcttcc ttcttccttc cttcctcctc ctcctccttc     6180

ttcttcctct tcctcttctt ctttctctct ttccttcctt cccttccctt ccccttcctt     6240

ccttccttcc ttccttcctc cctccctccc tccctccctc cctccctcct ttctttttct     6300

ttctctttct ttctttcttt ctctctctct ctctctttct ttctttttct ttctcttttt     6360

ctttctttca agcagtcctc ccgcctcagt cccccaaaat agtgggatta caggtgtgag     6420

ccaccatgca cagccttaca taaagccttt tctaatgaga tggatagtaa ttaacaaatg     6480

tgagtttttg atattatata aagatttttt ctgtgtttcg aagatccgta taactcagtg     6540

aatcagtatg ttctggatga ctaatatgtg atgttaagaa atcatgactg aggccgggcg     6600

cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggcgg atcacgagat     6660

caggagatcg agaccaccct ggccaacatg gtgaaacccc gtctctacta aaaatacaaa     6720

aattagctgg gtgtgttggt gcgtgcctat aatcccagct actcgggagg ctgaggcagg     6780

agaatcgctt gaactcagga ggcggagatt gcagtgagct gagactgcgc cactgcaccc     6840

cagcctggcg acagagcaag actccgtctc aaaaataaaa aaagaaatca tgactgggta     6900

aaagatctgt tcagagtaca agatggacca atggatttga tatatttgaa tataacagag     6960

tatgaaaaag tttattgata tagtttcaga ttacacactg caactaatct ttaagaaact     7020

attacttgtc cactttttgg taaaatttca gagaacaatg tccaccatta tctgaacagg     7080

ctattaaaat actcttctct tttccaacta cgtgcctgtg caaagtcaga tttttttcat     7140

atacttcagc caaaacagca tatcaaaatg gattgaatgc agaagtagat ctgagaatac     7200

agccactttt gttaagccag acaatgagat ttgcaaaatg taaacaatgc tgctgttctc     7260

agtttttaaa aatatgtttt ttaaaagtat ttatgttaat gtgtacttgg tttactactg     7320

ctatttttaa ataaaacaag aaacattttt aaatgtctgt tttaatttct aaagtggtag     7380

tgatagatat aacccatatt aataaaagct ctttggggtc ctcagtgatt tttttttaag     7440

agtatggaag ggttctcaga cctaagagat tgagaaatgc tgatgtaatg ttttattata     7500

aaggtgtacc atgaattatg taccttactt catattgttg gacattaaag ttgctttcag     7560

tttttttgtt ttaaa                                                      7575


<210>  566
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  566

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


<210>  567
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  567

Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
1               5                   10                  15      


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
            20                  25                  30          


Leu Ser Glu Asp Ile 
        35          


<210>  568
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  568

Met Ser Leu Ser Asp Gly Asp Val Val Gly Phe Asp Met Glu Trp Pro 
1               5                   10                  15      


Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys Val Ala Leu Ile Gln Leu 
            20                  25                  30          


Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe His Val Ser Ser Met Ser 
        35                  40                  45              


<210>  569
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  569

Phe Pro Gln Gly Leu Lys Met Leu Leu Glu Asn Lys Ala Val Lys Lys 
1               5                   10                  15      


Ala Gly Val Gly Ile Glu Gly Asp Gln Trp Lys Leu Leu Arg Asp Phe 
            20                  25                  30          


Asp Ile Lys Leu Lys Asn Phe Val Glu Leu Thr Asp Val Ala Asn Lys 
        35                  40                  45              


Lys 
    


<210>  570
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  570

Leu Lys Cys Thr Glu Thr Trp Ser Leu Asn Ser Leu Val Lys His Leu 
1               5                   10                  15      


Leu Gly Lys Gln Leu Leu Lys Asp Lys Ser Ile Arg Cys Ser Asn Trp 
            20                  25                  30          


Ser Lys Phe Pro Leu Thr Glu Asp Gln Lys Leu Tyr Ala Ala Thr Asp 
        35                  40                  45              


Ala Tyr 
    50  


<210>  571
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  571

Ala Gly Phe Ile Ile Tyr Arg Asn Leu Glu Ile Leu Asp Asp Thr Val 
1               5                   10                  15      


Gln Arg Phe Ala Ile Asn Lys 
            20              


<210>  572
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  572

Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser Ile Ser 
1               5                   10                  15      


Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe Ser Lys 
            20                  25                  30          


Leu Glu Asn Pro Arg 
        35          


<210>  573
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  573

Val Ser Ile Leu Leu Lys Asp Ile Ser Glu Asn Leu Tyr Ser Leu Arg 
1               5                   10                  15      


Arg Met Ile Ile Gly Ser Thr Asn Ile Glu Thr Glu Leu Arg Pro Ser 
            20                  25                  30          


Asn Asn Leu Asn Leu Leu Ser Phe Glu Asp Ser Thr Thr Gly Gly Val 
        35                  40                  45              


Gln Gln Lys Gln Ile Arg Glu His Glu Val Leu Ile His Val Glu Asp 
    50                  55                  60                  


Glu Thr Trp Asp Pro Thr Leu Asp His Leu Ala Lys His Asp Gly Glu 
65                  70                  75                  80  


Asp Val Leu Gly Asn Lys Val Glu Arg Lys Glu Asp Gly Phe Glu Asp 
                85                  90                  95      


Gly Val Glu Asp Asn Lys Leu Lys Glu Asn Met Glu Arg Ala Cys Leu 
            100                 105                 110         


Met Ser Leu Asp Ile Thr Glu His Glu Leu Gln Ile Leu Glu Gln Gln 
        115                 120                 125             


Ser Gln Glu Glu Tyr Leu Ser Asp Ile Ala Tyr Lys Ser Thr Glu 
    130                 135                 140             


<210>  574
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  574

His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val Ile Glu 
1               5                   10                  15      


Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys 
            20                  25          


<210>  575
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  575

His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val Ile Glu 
1               5                   10                  15      


Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys 
            20                  25          


<210>  576
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  576

Ser Leu Glu Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys 
1               5                   10                  15      


Cys Leu Lys Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu 
            20                  25                  30          


Glu Asp Asp Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys 
        35                  40                  45              


<210>  577
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  577

Phe Leu Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met 
1               5                   10                  15      


Tyr Phe Gly His Ser Ser Phe Lys 
            20                  


<210>  578
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  578

Val Gln Trp Lys Val Ile His Ser Val Leu Glu Glu Arg Arg Asp Asn 
1               5                   10                  15      


Val Ala Val Met Ala Thr 
            20          


<210>  579
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  579

Tyr Gly Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys 
1               5                   10                  15      


Ile Gly Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val 
            20                  25                  30          


Leu Gln Leu 
        35  


<210>  580
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  580

Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser Glu Asn 
1               5                   10                  15      


Val Leu Thr Asp Ile Lys 
            20          


<210>  581
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  581

Gly Lys Tyr Arg Ile Val Tyr Val Thr Pro Glu Tyr Cys Ser Gly Asn 
1               5                   10                  15      


Met Gly Leu Leu Gln Gln Leu Glu Ala Asp Ile 
            20                  25          


<210>  582
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  582

Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys Ile Ser Glu Trp Gly 
1               5                   10                  15      


His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly Ser Leu Lys Thr Ala 
            20                  25                  30          


Leu Pro Met 
        35  


<210>  583
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  583

Val Pro Ile Val Ala Leu Thr Ala Thr Ala Ser Ser Ser Ile Arg Glu 
1               5                   10                  15      


Asp Ile Val Arg Cys Leu Asn Leu Arg Asn Pro Gln Ile Thr Cys Thr 
            20                  25                  30          


Gly Phe Asp Arg Pro Asn Leu Tyr Leu Glu Val Arg Arg Lys Thr Gly 
        35                  40                  45              


Asn Ile Leu Gln Asp Leu Gln Pro Phe Leu Val Lys Thr 
    50                  55                  60      


<210>  584
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  584

Ser His Trp Glu Phe Glu Gly Pro Thr Ile Ile Tyr Cys Pro Ser Arg 
1               5                   10                  15      


Lys Met Thr Gln Gln Val Thr Gly Glu Leu Arg Lys Leu Asn Leu Ser 
            20                  25                  30          


Cys Gly Thr Tyr His Ala Gly Met Ser Phe Ser Thr Arg Lys Asp Ile 
        35                  40                  45              


His His Arg Phe Val Arg Asp Glu Ile Gln 
    50                  55              


<210>  585
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  585

Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
1               5                   10                  15      


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
            20                  25                  30          


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
        35                  40                  45              


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn 
    50                  55                  60  


<210>  586
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  586

His Leu Leu Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu 
1               5                   10                  15      


Lys Met Met Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg 
            20                  25                  30          


Arg 
    


<210>  587
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  587

Ile Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu 
1               5                   10                  15      


Gly Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser 
            20                  25                  30  


<210>  588
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  588

Leu Asp His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp 
1               5                   10                  15      


Phe Gly Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly 
            20                  25                  30          


Glu Lys Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser 
        35                  40                  45          


<210>  589
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  589

Asn Ser Gln Arg Leu Ala Asp Gln Tyr Arg Arg His Ser Leu Phe Gly 
1               5                   10                  15      


Thr Gly Lys Asp Gln Thr Glu Ser Trp Trp Lys Ala Phe Ser Arg Gln 
            20                  25                  30          


Leu Ile Thr Glu Gly Phe Leu Val Glu Val Ser Arg Tyr Asn Lys Phe 
        35                  40                  45              


Met Lys Ile Cys Ala Leu Thr Lys Lys 
    50                  55          


<210>  590
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  590

Gly Arg Asn Trp Leu His Lys Ala Asn Thr Glu Ser Gln Ser Leu Ile 
1               5                   10                  15      


Leu Gln Ala Asn Glu Glu Leu Cys Pro Lys Lys Leu Leu Leu Pro 
            20                  25                  30      


<210>  591
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  591

Ser Lys Thr Val Ser Ser Gly Thr Lys Glu His Cys Tyr Asn Gln Val 
1               5                   10                  15      


Pro Val Glu Leu Ser Thr Glu Lys Lys 
            20                  25  


<210>  592
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  592

Ser Asn Leu Glu Lys Leu Tyr Ser Tyr Lys Pro Cys Asp Lys Ile Ser 
1               5                   10                  15      


Ser Gly Ser Asn Ile Ser Lys Lys 
            20                  


<210>  593
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  593

Ile Met Val Gln Ser Pro Glu Lys Ala Tyr Ser Ser Ser Gln Pro Val 
1               5                   10                  15      


Ile Ser Ala Gln Glu Gln Glu Thr Gln 
            20                  25  


<210>  594
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  594

Ile Val Leu Tyr Gly Lys Leu Val Glu Ala Arg Gln Lys His Ala Asn 
1               5                   10                  15      


Lys Met Asp Val Pro Pro Ala Ile Leu Ala Thr Asn Lys Ile Leu Val 
            20                  25                  30          


Asp Met Ala Lys Met 
        35          


<210>  595
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  595

Pro Thr Thr Val Glu Asn Val Lys Arg Ile Asp Gly Val Ser Glu Gly 
1               5                   10                  15      


Lys Ala Ala Met Leu Ala Pro Leu Leu Glu Val Ile Lys His Phe Cys 
            20                  25                  30          


Gln Thr Asn Ser Val Gln 
        35              


<210>  596
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  596

Thr Asp Leu Phe Ser Ser Thr Lys Pro Gln Glu Glu Gln Lys Thr Ser 
1               5                   10                  15      


Leu Val Ala Lys Asn Lys Ile Cys Thr Leu Ser Gln Ser Met Ala Ile 
            20                  25                  30          


Thr Tyr Ser Leu Phe Gln Glu Lys Lys Met Pro Leu 
        35                  40                  


<210>  597
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  597

Lys Ser Ile Ala Glu Ser Arg Ile Leu Pro Leu Met Thr Ile Gly Met 
1               5                   10                  15      


His Leu Ser Gln Ala Val Lys Ala Gly Cys Pro Leu Asp Leu Glu Arg 
            20                  25                  30          


Ala Gly Leu Thr Pro Glu Val Gln Lys Ile Ile Ala Asp Val Ile Arg 
        35                  40                  45              


Asn Pro Pro Val Asn Ser 
    50                  


<210>  598
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  598

Met Ser Lys Ile Ser Leu Ile Arg Met Leu Val Pro Glu Asn Ile Asp 
1               5                   10                  15      


Thr Tyr Leu Ile His Met Ala Ile Glu Ile Leu Lys His Gly Pro Asp 
            20                  25                  30          


Ser Gly Leu Gln Pro Ser Cys Asp Val Asn Lys Arg Arg Cys Phe Pro 
        35                  40                  45              


Gly Ser Glu Glu Ile Cys Ser Ser Ser Lys Arg Ser Lys Glu Glu Val 
    50                  55                  60                  


Gly Ile Asn Thr Glu 
65                  


<210>  599
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  599

Thr Ser Ser Ala Glu Arg Lys Arg Arg Leu Pro Val Trp Phe Ala Lys 
1               5                   10                  15      


Gly Ser Asp Thr Ser Lys Lys Leu Met Asp Lys Thr Lys Arg Gly Gly 
            20                  25                  30          


Leu Phe Ser 
        35  


<210>  600
<211>  1432
<212>  PRT
<213>  Homo sapiens

<400>  600

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Ser Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser Asp Met Ser  Lys Ile Ser Leu Ile  Arg Met Leu 
    1325                 1330                 1335             


Val Pro  Glu Asn Ile Asp Thr  Tyr Leu Ile His Met  Ala Ile Glu 
    1340                 1345                 1350             


Ile Leu  Lys His Gly Pro Asp  Ser Gly Leu Gln Pro  Ser Cys Asp 
    1355                 1360                 1365             


Val Asn  Lys Arg Arg Cys Phe  Pro Gly Ser Glu Glu  Ile Cys Ser 
    1370                 1375                 1380             


Ser Ser  Lys Arg Ser Lys Glu  Glu Val Gly Ile Asn  Thr Glu Thr 
    1385                 1390                 1395             


Ser Ser  Ala Glu Arg Lys Arg  Arg Leu Pro Val Trp  Phe Ala Lys 
    1400                 1405                 1410             


Gly Ser  Asp Thr Ser Lys Lys  Leu Met Asp Lys Thr  Lys Arg Gly 
    1415                 1420                 1425             


Gly Leu  Phe Ser 
    1430         


<210>  601
<211>  4222
<212>  DNA
<213>  Homo sapiens

<400>  601
gtgtactgtg tgcgccgggg aggcgccggc ttgtactcgg cagcgcggga ataaagtttg       60

ctgatttggt gtctagcctg gatgcctggg ttgcaggccc tgcttgtggt ggcgctccac      120

agtcatccgg ctgaagaaga cctgttggac tggatcttct cgggttttct ttcagatatt      180

gttttgtatt tacccatgaa gacattgttt tttggactct gcaaatagga catttcaaag      240

atgagtgaaa aaaaattgga aacaactgca cagcagcgga aatgtcctga atggatgaat      300

gtgcagaata aaagatgtgc tgtagaagaa agaaaggcat gtgttcggaa gagtgttttt      360

gaagatgacc tccccttctt agaattcact ggatccattg tgtatagtta cgatgctagt      420

gattgctctt tcctgtcaga agatattagc atgagtctat cagatgggga tgtggtggga      480

tttgacatgg agtggccacc attatacaat agagggaaac ttggcaaagt tgcactaatt      540

cagttgtgtg tttctgagag caaatgttac ttgttccacg tttcttccat gtcagttttt      600

ccccagggat taaaaatgtt gcttgaaaat aaagcagtta aaaaggcagg tgtaggaatt      660

gaaggagatc agtggaaact tctacgtgac tttgatatca aattgaagaa ttttgtggag      720

ttgacagatg ttgccaataa aaagctgaaa tgcacagaga cctggagcct taacagtctg      780

gttaaacacc tcttaggtaa acagctcctg aaagacaagt ctatccgctg tagcaattgg      840

agtaaatttc ctctcactga ggaccagaaa ctgtatgcag ccactgatgc ttatgctggt      900

tttattattt accgaaattt agagattttg gatgatactg tgcaaaggtt tgctataaat      960

aaagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa     1020

gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg     1080

gtttctatct tactaaagga tatttcagaa aatctatatt cactgaggag gatgataatt     1140

gggtctacta acattgagac tgaactgagg cccagcaata atttaaactt attatccttt     1200

gaagattcaa ctactggggg agtacaacag aaacaaatta gagaacatga agttttaatt     1260

cacgttgaag atgaaacatg ggacccaaca cttgatcatt tagctaaaca tgatggagaa     1320

gatgtacttg gaaataaagt ggaacgaaaa gaagatggat ttgaagatgg agtagaagac     1380

aacaaattga aagagaatat ggaaagagct tgtttgatgt cgttagatat tacagaacat     1440

gaactccaaa ttttggaaca gcagtctcag gaagaatatc ttagtgatat tgcttataaa     1500

tctactgagc atttatctcc caatgataat gaaaacgata cgtcctatgt aattgagagt     1560

gatgaagatt tagaaatgga gatgcttaag catttatctc ccaatgataa tgaaaacgat     1620

acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa gtctttagaa     1680

aacctcaata gtggcacggt agaaccaact cattctaaat gcttaaaaat ggaaagaaat     1740

ctgggtcttc ctactaaaga agaagaagaa gatgatgaaa atgaagctaa tgaaggggaa     1800

gaagatgatg ataaggactt tttgtggcca gcacccaatg aagagcaagt tacttgcctc     1860

aagatgtact ttggccattc cagttttaaa ccagttcagt ggaaagtgat tcattcagta     1920

ttagaagaaa gaagagataa tgttgctgtc atggcaactg gatatggaaa gagtttgtgc     1980

ttccagtatc cacctgttta tgtaggcaag attggccttg ttatctctcc ccttatttct     2040

ctgatggaag accaagtgct acagcttaaa atgtccaaca tcccagcttg cttccttgga     2100

tcagcacagt cagaaaatgt tctaacagat attaaattag gtaaataccg gattgtatac     2160

gtaactccag aatactgttc aggtaacatg ggcctgctcc agcaacttga ggctgatatt     2220

ggtatcacgc tcattgctgt ggatgaggct cactgtattt ctgagtgggg gcatgatttt     2280

agggattcat tcaggaagtt gggctcccta aagacagcac tgccaatggt tccaatcgtt     2340

gcacttactg ctactgcaag ttcttcaatc cgggaagaca ttgtacgttg cttaaatctg     2400

agaaatcctc agatcacctg tactggtttt gatcgaccaa acctgtattt agaagttagg     2460

cgaaaaacag ggaatatcct tcaggatctg cagccatttc ttgtcaaaac aagttcccac     2520

tgggaatttg aaggtccaac aatcatctac tgtccttcta gaaaaatgac acaacaagtt     2580

acaggtgaac ttaggaaact gaatctatcc tgtggaacat accatgcggg catgagtttt     2640

agcacaagga aagacattca tcataggttt gtaagagatg aaattcagtg tgtcatagct     2700

accatagctt ttggaatggg cattaataaa gctgacattc gccaagtcat tcattacggt     2760

gctcctaagg acatggaatc atattatcag gagattggta gagctggtcg tgatggactt     2820

caaagttctt gtcacgtcct ctgggctcct gcagacatta acttaaatag gcaccttctt     2880

actgagatac gtaatgagaa gtttcgatta tacaaattaa agatgatggc aaagatggaa     2940

aaatatcttc attctagcag atgtaggaga caaatcatct tgtctcattt tgaggacaaa     3000

caagtacaaa aagcctcctt gggaattatg ggaactgaaa aatgctgtga taattgcagg     3060

tccagattgg atcattgcta ttccatggat gactcagagg atacatcctg ggactttggt     3120

ccacaagcat ttaagctttt gtctgctgtg gacatcttag gcgaaaaatt tggaattggg     3180

cttccaattt tatttctccg aggatctaat tctcagcgtc ttgccgatca atatcgcagg     3240

cacagtttat ttggcactgg caaggatcaa acagagagtt ggtggaaggc tttttcccgt     3300

cagctgatca ctgagggatt cttggtagaa gtttctcggt ataacaaatt tatgaagatt     3360

tgcgccctta cgaaaaaggg tagaaattgg cttcataaag ctaatacaga atctcagagc     3420

ctcatccttc aagctaatga agaattgtgt ccaaagaagt tgcttctgcc tagttcgaaa     3480

actgtatctt cgggcaccaa agagcattgt tataatcaag taccagttga attaagtaca     3540

gagaagaagt ctaacttgga gaagttatat tcttataaac catgtgataa gatttcttct     3600

gggagtaaca tttctaaaaa aagtatcatg gtacagtcac cagaaaaagc ttacagttcc     3660

tcacagcctg ttatttcggc acaagagcag gagactcaga ttgtgttata tggcaaattg     3720

gtagaagcta ggcagaaaca tgccaataaa atggatgttc ccccagctat tctggcaaca     3780

aacaagatac tggtggatat ggccaaaatg agaccaacta cggttgaaaa cgtaaaaagg     3840

attgatggtg tttctgaagg caaagctgcc atgttggccc ctctgttgga agtcatcaaa     3900

catttctgcc aaacaaatag tgttcagaca gacctctttt caagtacaaa acctcaagaa     3960

gaacagaaga cgagtctggt agcaaaaaat aaaatatgca cactttcaca gtctatggcc     4020

atcacatact ctttattcca agaaaagaag atgcctttga agagcatagc tgagagcagg     4080

attctgcctc tcatgacaat tggcatgcac ttatcccaag cggtgaaagc tggctgcccc     4140

cttgatttgg agcgagcagg cctgactcca gaggttcaga agattattgc tgatgttatc     4200

cgaaaccctc ccgtcaactc ag                                              4222


<210>  602
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Ser Glu Lys Lys Leu Glu Thr Thr Ala Gln Gln Arg Lys Cys Pro 
1               5                   10                  15      


Glu Trp Met Asn Val Gln Asn Lys Arg Cys Ala Val Glu Glu Arg Lys 
            20                  25                  30          


Ala Cys Val Arg Lys Ser Val Phe Glu Asp Asp Leu Pro Phe Leu Glu 
        35                  40                  45              


Phe Thr Gly Ser Ile Val Tyr Ser Tyr Asp Ala Ser Asp Cys Ser Phe 
    50                  55                  60                  


Leu Ser Glu Asp Ile Ser Met Ser Leu Ser Asp Gly Asp Val Val Gly 
65                  70                  75                  80  


Phe Asp Met Glu Trp Pro Pro Leu Tyr Asn Arg Gly Lys Leu Gly Lys 
                85                  90                  95      


Val Ala Leu Ile Gln Leu Cys Val Ser Glu Ser Lys Cys Tyr Leu Phe 
            100                 105                 110         


His Val Ser Ser Met Ser Val Phe Pro Gln Gly Leu Lys Met Leu Leu 
        115                 120                 125             


Glu Asn Lys Ala Val Lys Lys Ala Gly Val Gly Ile Glu Gly Asp Gln 
    130                 135                 140                 


Trp Lys Leu Leu Arg Asp Phe Asp Ile Lys Leu Lys Asn Phe Val Glu 
145                 150                 155                 160 


Leu Thr Asp Val Ala Asn Lys Lys Leu Lys Cys Thr Glu Thr Trp Ser 
                165                 170                 175     


Leu Asn Ser Leu Val Lys His Leu Leu Gly Lys Gln Leu Leu Lys Asp 
            180                 185                 190         


Lys Ser Ile Arg Cys Ser Asn Trp Ser Lys Phe Pro Leu Thr Glu Asp 
        195                 200                 205             


Gln Lys Leu Tyr Ala Ala Thr Asp Ala Tyr Ala Gly Phe Ile Ile Tyr 
    210                 215                 220                 


Arg Asn Leu Glu Ile Leu Asp Asp Thr Val Gln Arg Phe Ala Ile Asn 
225                 230                 235                 240 


Lys Glu Glu Glu Ile Leu Leu Ser Asp Met Asn Lys Gln Leu Thr Ser 
                245                 250                 255     


Ile Ser Glu Glu Val Met Asp Leu Ala Lys His Leu Pro His Ala Phe 
            260                 265                 270         


Ser Lys Leu Glu Asn Pro Arg Arg Val Ser Ile Leu Leu Lys Asp Ile 
        275                 280                 285             


Ser Glu Asn Leu Tyr Ser Leu Arg Arg Met Ile Ile Gly Ser Thr Asn 
    290                 295                 300                 


Ile Glu Thr Glu Leu Arg Pro Ser Asn Asn Leu Asn Leu Leu Ser Phe 
305                 310                 315                 320 


Glu Asp Ser Thr Thr Gly Gly Val Gln Gln Lys Gln Ile Arg Glu His 
                325                 330                 335     


Glu Val Leu Ile His Val Glu Asp Glu Thr Trp Asp Pro Thr Leu Asp 
            340                 345                 350         


His Leu Ala Lys His Asp Gly Glu Asp Val Leu Gly Asn Lys Val Glu 
        355                 360                 365             


Arg Lys Glu Asp Gly Phe Glu Asp Gly Val Glu Asp Asn Lys Leu Lys 
    370                 375                 380                 


Glu Asn Met Glu Arg Ala Cys Leu Met Ser Leu Asp Ile Thr Glu His 
385                 390                 395                 400 


Glu Leu Gln Ile Leu Glu Gln Gln Ser Gln Glu Glu Tyr Leu Ser Asp 
                405                 410                 415     


Ile Ala Tyr Lys Ser Thr Glu His Leu Ser Pro Asn Asp Asn Glu Asn 
            420                 425                 430         


Asp Thr Ser Tyr Val Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met 
        435                 440                 445             


Leu Lys His Leu Ser Pro Asn Asp Asn Glu Asn Asp Thr Ser Tyr Val 
    450                 455                 460                 


Ile Glu Ser Asp Glu Asp Leu Glu Met Glu Met Leu Lys Ser Leu Glu 
465                 470                 475                 480 


Asn Leu Asn Ser Gly Thr Val Glu Pro Thr His Ser Lys Cys Leu Lys 
                485                 490                 495     


Met Glu Arg Asn Leu Gly Leu Pro Thr Lys Glu Glu Glu Glu Asp Asp 
            500                 505                 510         


Glu Asn Glu Ala Asn Glu Gly Glu Glu Asp Asp Asp Lys Asp Phe Leu 
        515                 520                 525             


Trp Pro Ala Pro Asn Glu Glu Gln Val Thr Cys Leu Lys Met Tyr Phe 
    530                 535                 540                 


Gly His Ser Ser Phe Lys Pro Val Gln Trp Lys Val Ile His Ser Val 
545                 550                 555                 560 


Leu Glu Glu Arg Arg Asp Asn Val Ala Val Met Ala Thr Gly Tyr Gly 
                565                 570                 575     


Lys Ser Leu Cys Phe Gln Tyr Pro Pro Val Tyr Val Gly Lys Ile Gly 
            580                 585                 590         


Leu Val Ile Ser Pro Leu Ile Ser Leu Met Glu Asp Gln Val Leu Gln 
        595                 600                 605             


Leu Lys Met Ser Asn Ile Pro Ala Cys Phe Leu Gly Ser Ala Gln Ser 
    610                 615                 620                 


Glu Asn Val Leu Thr Asp Ile Lys Leu Gly Lys Tyr Arg Ile Val Tyr 
625                 630                 635                 640 


Val Thr Pro Glu Tyr Cys Ser Gly Asn Met Gly Leu Leu Gln Gln Leu 
                645                 650                 655     


Glu Ala Asp Ile Gly Ile Thr Leu Ile Ala Val Asp Glu Ala His Cys 
            660                 665                 670         


Ile Ser Glu Trp Gly His Asp Phe Arg Asp Ser Phe Arg Lys Leu Gly 
        675                 680                 685             


Ser Leu Lys Thr Ala Leu Pro Met Val Pro Ile Val Ala Leu Thr Ala 
    690                 695                 700                 


Thr Ala Ser Ser Ser Ile Arg Glu Asp Ile Val Arg Cys Leu Asn Leu 
705                 710                 715                 720 


Arg Asn Pro Gln Ile Thr Cys Thr Gly Phe Asp Arg Pro Asn Leu Tyr 
                725                 730                 735     


Leu Glu Val Arg Arg Lys Thr Gly Asn Ile Leu Gln Asp Leu Gln Pro 
            740                 745                 750         


Phe Leu Val Lys Thr Ser Ser His Trp Glu Phe Glu Gly Pro Thr Ile 
        755                 760                 765             


Ile Tyr Cys Pro Ser Arg Lys Met Thr Gln Gln Val Thr Gly Glu Leu 
    770                 775                 780                 


Arg Lys Leu Asn Leu Ser Cys Gly Thr Tyr His Ala Gly Met Ser Phe 
785                 790                 795                 800 


Ser Thr Arg Lys Asp Ile His His Arg Phe Val Arg Asp Glu Ile Gln 
                805                 810                 815     


Cys Val Ile Ala Thr Ile Ala Phe Gly Met Gly Ile Asn Lys Ala Asp 
            820                 825                 830         


Ile Arg Gln Val Ile His Tyr Gly Ala Pro Lys Asp Met Glu Ser Tyr 
        835                 840                 845             


Tyr Gln Glu Ile Gly Arg Ala Gly Arg Asp Gly Leu Gln Ser Ser Cys 
    850                 855                 860                 


His Val Leu Trp Ala Pro Ala Asp Ile Asn Leu Asn Arg His Leu Leu 
865                 870                 875                 880 


Thr Glu Ile Arg Asn Glu Lys Phe Arg Leu Tyr Lys Leu Lys Met Met 
                885                 890                 895     


Ala Lys Met Glu Lys Tyr Leu His Ser Ser Arg Cys Arg Arg Gln Ile 
            900                 905                 910         


Ile Leu Ser His Phe Glu Asp Lys Gln Val Gln Lys Ala Ser Leu Gly 
        915                 920                 925             


Ile Met Gly Thr Glu Lys Cys Cys Asp Asn Cys Arg Ser Arg Leu Asp 
    930                 935                 940                 


His Cys Tyr Ser Met Asp Asp Ser Glu Asp Thr Ser Trp Asp Phe Gly 
945                 950                 955                 960 


Pro Gln Ala Phe Lys Leu Leu Ser Ala Val Asp Ile Leu Gly Glu Lys 
                965                 970                 975     


Phe Gly Ile Gly Leu Pro Ile Leu Phe Leu Arg Gly Ser Asn Ser Gln 
            980                 985                 990         


Arg Leu Ala Asp Gln Tyr Arg Arg  His Ser Leu Phe Gly  Thr Gly Lys 
        995                 1000                 1005             


Asp Gln  Thr Glu Ser Trp Trp  Lys Ala Phe Ser Arg  Gln Leu Ile 
    1010                 1015                 1020             


Thr Glu  Gly Phe Leu Val Glu  Val Ser Arg Tyr Asn  Lys Phe Met 
    1025                 1030                 1035             


Lys Ile  Cys Ala Leu Thr Lys  Lys Gly Arg Asn Trp  Leu His Lys 
    1040                 1045                 1050             


Ala Asn  Thr Glu Ser Gln Ser  Leu Ile Leu Gln Ala  Asn Glu Glu 
    1055                 1060                 1065             


Leu Cys  Pro Lys Lys Leu Leu  Leu Pro Ser Ser Lys  Thr Val Ser 
    1070                 1075                 1080             


Ser Gly  Thr Lys Glu His Cys  Tyr Asn Gln Val Pro  Val Glu Leu 
    1085                 1090                 1095             


Ser Thr  Glu Lys Lys Ser Asn  Leu Glu Lys Leu Tyr  Ser Tyr Lys 
    1100                 1105                 1110             


Pro Cys  Asp Lys Ile Ser Ser  Gly Ser Asn Ile Ser  Lys Lys Ser 
    1115                 1120                 1125             


Ile Met  Val Gln Ser Pro Glu  Lys Ala Tyr Ser Ser  Ser Gln Pro 
    1130                 1135                 1140             


Val Ile  Ser Ala Gln Glu Gln  Glu Thr Gln Ile Val  Leu Tyr Gly 
    1145                 1150                 1155             


Lys Leu  Val Glu Ala Arg Gln  Lys His Ala Asn Lys  Met Asp Val 
    1160                 1165                 1170             


Pro Pro  Ala Ile Leu Ala Thr  Asn Lys Ile Leu Val  Asp Met Ala 
    1175                 1180                 1185             


Lys Met  Arg Pro Thr Thr Val  Glu Asn Val Lys Arg  Ile Asp Gly 
    1190                 1195                 1200             


Val Ser  Glu Gly Lys Ala Ala  Met Leu Ala Pro Leu  Leu Glu Val 
    1205                 1210                 1215             


Ile Lys  His Phe Cys Gln Thr  Asn Ser Val Gln Thr  Asp Leu Phe 
    1220                 1225                 1230             


Ser Ser  Thr Lys Pro Gln Glu  Glu Gln Lys Thr Ser  Leu Val Ala 
    1235                 1240                 1245             


Lys Asn  Lys Ile Cys Thr Leu  Ser Gln Ser Met Ala  Ile Thr Tyr 
    1250                 1255                 1260             


Ser Leu  Phe Gln Glu Lys Lys  Met Pro Leu Lys Ser  Ile Ala Glu 
    1265                 1270                 1275             


Ser Arg  Ile Leu Pro Leu Met  Thr Ile Gly Met His  Leu Ser Gln 
    1280                 1285                 1290             


Ala Val  Lys Ala Gly Cys Pro  Leu Asp Leu Glu Arg  Ala Gly Leu 
    1295                 1300                 1305             


Thr Pro  Glu Val Gln Lys Ile  Ile Ala Asp Val Ile  Arg Asn Pro 
    1310                 1315                 1320             


Pro Val  Asn Ser 
    1325         


<210>  603
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  603
gaaggaaact gtttaaccgg atcccattgt acccagagtg cagagccgcc tttccagcat       60

gcaggggctg ctcag                                                        75


<210>  604
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  604
gacagagagg gaggaggcgc gcggggacgg ggacgcccag gaggacccac tcgcgggtcc       60

cgctccgctc cggca                                                        75


<210>  605
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  605
gaaggaaact gtttaaccgg atcccattgt acccagagtg cagagccgcc tttccagcat       60

gcaggggctg ctcaggacag agagggagga ggcgcgcggg gacggggacg cccaggagga      120

cccactcgcg ggtcccgctc cgctccggca                                       150


<210>  606
<211>  102
<212>  DNA
<213>  Homo sapiens

<400>  606
gcgagttagt aacctacgag cggctgtgaa ggaaactgtt taaccggatc ccattgtacc       60

cagagtgcag agccgccttt ccagcatgca ggggctgctc ag                         102


<210>  607
<211>  220
<212>  DNA
<213>  Homo sapiens

<400>  607
cgtttagtca catcaagaaa tagaacagaa ttcagccatg gccccaagaa agagaggtgg       60

acgaggtatt tcattcatct tttgctgttt ccgaaataat gatcacccag aaatcacgta      120

tcggctgcga aatgatagca actttgcgct tcagaccatg gaaccagcat tgcccatgcc      180

ccctgtggag gagctggatg tcatgttcag tgaactggtg                            220


<210>  608
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  608
gatgaactgg acctcacaga caaacacaga gaagccatgt ttgcacttcc agctgagaaa       60

aaatggcaaa tatactgtag caagaaaaag                                        90


<210>  609
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  609
gaccaggaag aaaacaaggg agctacaagt tggcctgaat tctacattga tcagctcaat       60

tccatggctg ct                                                           72


<210>  610
<211>  95
<212>  DNA
<213>  Homo sapiens

<400>  610
agaaaatctc tgctggcttt agagaaggaa gaagaagaag aaagaagtaa aactatagag       60

agtttaaaga cagcactgag gacaaaacca atgag                                  95


<210>  611
<211>  334
<212>  DNA
<213>  Homo sapiens

<400>  611
gtttgtaacc agattcatcg acttggatgg cctatcatgt atcctcaact ttctaaagac       60

catggactac gagacctcag agtctcgaat acatacttct ctcattggct gtataaaggc      120

gttaatgaac aactctcaag gccgggctca cgtcctggct cattctgaga gtattaatgt      180

aattgctcag agtctgagca cagagaacat taaaacgaag gtggccgtgc tggaaatctt      240

gggcgccgtg tgcctggttc ccgggggcca caagaaggtt ctgcaggcca tgctgcacta      300

ccagaagtat gccagcgaaa ggacccgctt tcag                                  334


<210>  612
<211>  111
<212>  DNA
<213>  Homo sapiens

<400>  612
acattaatta acgacttgga taaaagcact gggcggtatc gagatgaagt gagtctcaag       60

actgccatca tgtccttcat taatgcagtg ctcagccaag gtgcaggagt g               111


<210>  613
<211>  104
<212>  DNA
<213>  Homo sapiens

<400>  613
gagagtttgg actttagact tcatcttcgc tatgaatttc tgatgttagg aattcaacct       60

gtaatagata aattaaggga acacgaaaat tcaacattag atag                       104


<210>  614
<211>  67
<212>  DNA
<213>  Homo sapiens

<400>  614
gcatttagac ttttttgaaa tgctccgaaa tgaagatgaa ctagaatttg ccaaaagatt       60

tgaactg                                                                 67


<210>  615
<211>  118
<212>  DNA
<213>  Homo sapiens

<400>  615
gttcacatag acacaaaaag tgcaactcag atgtttgagc tgaccaggaa gaggctgaca       60

catagtgaag cttacccgca tttcatgtcc atcctgcacc actgcctcca aatgcctt        118


<210>  616
<211>  139
<212>  DNA
<213>  Homo sapiens

<400>  616
acaagaggag tggcaacact gttcagtact ggctactact agatagaatt atacagcaga       60

tagttatcca gaatgacaaa ggacaggacc ctgactccac acctttggaa aactttaata      120

ttaagaatgt cgtacgaat                                                   139


<210>  617
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  617
gttggttaat gaaaatgaag ttaagcagtg gaaagaacaa gcggaaaaaa tgagaaaag        59


<210>  618
<211>  188
<212>  DNA
<213>  Homo sapiens

<400>  618
agcacaatga gctacaacag aaactggaaa agaaagaacg agaatgtgat gctaagactc       60

aagagaagga agagatgatg cagaccttaa ataaaatgaa agagaaactt gaaaaggaga      120

ctactgagca taagcaagtc aagcagcagg tggcggacct cacagcacag ctccatgagc      180

tcagcagg                                                               188


<210>  619
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  619
agggccgtct gtgcttcaat cccaggtgga ccctcgcctg gagcaccagg agggcccttt       60

ccttcctctg tgcctggatc tctccttcct cccccaccac ccccacctct accaggtggg      120

atgcttcccc ctccaccgcc tcccctccct ccaggtggcc ctcctcctcc cccagggcct      180

cctcccttag gggcaatcat gccacctcct ggtgctccaa tgggcctagc actgaagaag      240

aaaagcattc ctcagcccac aaatgccctg aaatccttca actggtctaa actgcccgag      300


<210>  620
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  620
aacaaactgg aaggaacagt atggaccgaa attgatgata caaaagtctt caaaattcta       60

gatcttgaag acctggaaag aaccttctct gcctatcaaa gacagcag                   108


<210>  621
<211>  107
<212>  DNA
<213>  Homo sapiens

<400>  621
aaagaagcag atgccattga tgacactctg agttccaaac ttaaagttaa agagctttcg       60

gtgattgatg gtcggagagc tcagaattgc aacatccttc tatcgag                    107


<210>  622
<211>  85
<212>  DNA
<213>  Homo sapiens

<400>  622
gttgaaatta tccaatgacg aaatcaaacg ggcaattcta acaatggacg aacaggaaga       60

tctgcccaag gacatgttgg aacag                                             85


<210>  623
<211>  107
<212>  DNA
<213>  Homo sapiens

<400>  623
ctcttgaaat ttgttcctga aaaaagtgac attgacctat tggaggaaca taaacacgaa       60

ctggatcgga tggccaaggc tgataggttc ctttttgaga tgagccg                    107


<210>  624
<211>  89
<212>  DNA
<213>  Homo sapiens

<400>  624
aattaatcac tatcagcaaa ggttgcaatc gctgtacttc aaaaagaagt ttgcagagcg       60

tgtggcagaa gtgaaaccta aagtggaag                                         89


<210>  625
<211>  169
<212>  DNA
<213>  Homo sapiens

<400>  625
caattcgttc tggctcagaa gaggtgttta ggagtggtgc cctcaagcag ttgctggagg       60

tggttttggc atttggaaat tatatgaata aaggtcaaag agggaatgca tatggattca      120

agatatctag cctaaacaaa attgctgaca caaaatccag catcgacaa                  169


<210>  626
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  626
aaacattacc cttttgcact atctcatcac tattgtggaa aataagtacc ccagtgttct       60

caatctaaat gaagaattgc gagatattcc tcaagctgcg aaagtaaa                   108


<210>  627
<211>  61
<212>  DNA
<213>  Homo sapiens

<400>  627
catgactgag ctggacaaag aaataagtac cttgagaagt ggcttgaaag cagtagagac       60

a                                                                       61


<210>  628
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  628
gagctggaat atcagaagtc tcagccccca cagcccggag ataagtttgt gtctgttgtc       60

agccagttca tcacagtagc cagcttcagc ttctctgatg ttgaagacct tctagcagaa      120

gctaaagacc tg                                                          132


<210>  629
<211>  171
<212>  DNA
<213>  Homo sapiens

<400>  629
tttactaaag cagtgaagca ctttggggaa gaggctggca aaatacaacc agatgagttc       60

tttggcattt ttgatcaatt tcttcaagct gtgtcagaag ccaaacaaga aaacgaaaat      120

atgagaaaga aaaaggagga agaagaacgt cgagctcgca tggaagctca g               171


<210>  630
<211>  2754
<212>  DNA
<213>  Homo sapiens

<400>  630
ctcaaagaac aacgtgaaag ggaacgtaaa atgagaaaag ctaaagagaa tagtgaagaa       60

agcggagagt ttgatgacct tgtttcagct ttacgctcag gagaagtgtt tgacaaagac      120

ctttctaaat tgaaacggaa tcgcaaacgt attaccaacc agatgactga cagcagcaga      180

gagagaccaa tcacaaaact taatttctaa ttttccatga atactttttt ttagaaagct      240

cattagcagc cctctaaagt gactagaacg tttcattaca ctgccttgca atccaaacag      300

tggcaatttt ttccttcatc tgtgagtgaa tgtgtgaacg tgtgtatgta aatgtatgtg      360

tgtatatatt aaaaaatgta tatagatgtc tgagtgttgt ctggagacct atacgtatgg      420

ttaaaaagat ttatgttaat gtatgtgctc caaaaccttt cgtgtatgca ttcacattga      480

gtgtggctca ttttctttcc ccgaacgcca tgactgttca gaagcacaat actatctcct      540

gaaagagata agagacattc cctagattca aaggcaaaac agaagaaaca aacaaacaaa      600

caaaaaaagc ttgcaaaata ttttatggtt tccaagcttg atatccttta aaattatttt      660

cattgatgga actggagttg ttggaaaaac atagatttaa aatgattttt gatagctgac      720

attgtgatgt tgatgtatca catcagtaat aggaccagct ttgaatttct gacattggtg      780

tggggataca gtctgtaaat gtttattgag aacatcttgc acacaatttg aattatgtag      840

aatgtcaatc aagtttttgt atatttaaaa gttggacatc aattttttcc cctgatttca      900

tcaagttatc tctgccaagt gctcttgata atttcttcag atttttggaa aaaaacacta      960

tataaatgca atccatgctt tttttaaaga acaacattgc cagagtatgc ttgttctaac     1020

aatatagata tataaacctt aaaaataata aaatatctca cccaagactt aaaggaagaa     1080

ttctctgaag ggataaagat tactaaaaaa aaaaaaaaaa aaaaaaaatt aatggggtgc     1140

ctttttgtta tagtttctat tttctgtttt gtaggacaag ctgcattttc tgtaaatata     1200

ggtctggact aaaggataca taaagaatgc acaaaatgtc aacatcagca gagatgccca     1260

gatctattta tctctaagta tatttgaagt gattgctgtt tatatgttgt cattttaaaa     1320

ttgtgtgtca gtaaagctac ctgtaaaatt tcagtccaaa aaaataaagc tctcagggag     1380

acatgaataa aatcaatgaa cattagaaaa taaaatatag atgcttacca ttaacctacc     1440

aactcttaat atccttaaat tatgtgatat ataaagagga ctgttacttt tttacttttt     1500

tttttttttt tttttttttt tggctttgct ttatttattt gtagttgggg gctaacgttt     1560

tctcttttct ttctattgat cctgttgtgg ttgggtttcc tgtggagaga gtagtttgtc     1620

ctgttgcact agaacattat ttactcacta aattgagttt ttcagtcaat taacaaatat     1680

ttattaagtt cctactatgt accaggcata gtagggctac aatggtaagc aagacagagt     1740

ccctgccccc aaagagctta tattctaatg gggatattaa gggatgaata gaataccaat     1800

gtgtgcactg tacaggaatc atactattta aaaataattt gtataaacta taatgcttag     1860

cacagatggc gagttatctg tgctatgtga aagctgtgaa atagtgctct aagagttgtc     1920

aagagctgtg gttttacatc ttttcctcat tgcaaattta gtgactttct acacactata     1980

tggaaataaa tgactagcaa ataaaacagt cataaataca aagcagaggt tgcactcccc     2040

caatcccgag ttaacccagg tctgcaataa caccatgtta aaggtgcaga tagagacttg     2100

gctcaaaaag gcttggagat gaggaagatt ggaatataat gatggttttg tctgttcctt     2160

aactaaagtg cctctatgta tattcttttc tatttgtagc aggataaatt tggtctggct     2220

cagttttgga actgtatttt gaaaatggct ttgtcttaca gtttaaggaa tagacaggtg     2280

gagggaaagt cacataaagg agcaagtttg tgtagctgtc cctcttgccc cttttaatca     2340

tcctcctttg atatggccat cctggtgggc ctcctttgcc atttccattt ttggtttctt     2400

tccctgaaaa ctgtgtgcag gtaattccat gtgccattgt tgaaaagaaa aaaaaaaaac     2460

aaaaaaaaaa cctacttttt agattggtgc tggtgtaagt agccactttt ctctcttggg     2520

tgtgtatttt aaactttttt tgttttttta aattaatgcc aaaaagaaaa tgcataattt     2580

gtaaacttaa ttatatgtct tatatcttat tagcttagta gttggaacca cttagtcttt     2640

aggtgcaaga ctgttgttag atagtactga gaaaaaaaaa gtatgtgtta tgagactgta     2700

catgtttttt taaaaatagc aatatgcaat aaagagatga attcattggg tgta           2754


<210>  631
<211>  5890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of DAAM1

<400>  631
gcgagttagt aacctacgag cggctgtgaa ggaaactgtt taaccggatc ccattgtacc       60

cagagtgcag agccgccttt ccagcatgca ggggctgctc agcgtttagt cacatcaaga      120

aatagaacag aattcagcca tggccccaag aaagagaggt ggacgaggta tttcattcat      180

cttttgctgt ttccgaaata atgatcaccc agaaatcacg tatcggctgc gaaatgatag      240

caactttgcg cttcagacca tggaaccagc attgcccatg ccccctgtgg aggagctgga      300

tgtcatgttc agtgaactgg tggatgaact ggacctcaca gacaaacaca gagaagccat      360

gtttgcactt ccagctgaga aaaaatggca aatatactgt agcaagaaaa aggaccagga      420

agaaaacaag ggagctacaa gttggcctga attctacatt gatcagctca attccatggc      480

tgctagaaaa tctctgctgg ctttagagaa ggaagaagaa gaagaaagaa gtaaaactat      540

agagagttta aagacagcac tgaggacaaa accaatgagg tttgtaacca gattcatcga      600

cttggatggc ctatcatgta tcctcaactt tctaaagacc atggactacg agacctcaga      660

gtctcgaata catacttctc tcattggctg tataaaggcg ttaatgaaca actctcaagg      720

ccgggctcac gtcctggctc attctgagag tattaatgta attgctcaga gtctgagcac      780

agagaacatt aaaacgaagg tggccgtgct ggaaatcttg ggcgccgtgt gcctggttcc      840

cgggggccac aagaaggttc tgcaggccat gctgcactac cagaagtatg ccagcgaaag      900

gacccgcttt cagacattaa ttaacgactt ggataaaagc actgggcggt atcgagatga      960

agtgagtctc aagactgcca tcatgtcctt cattaatgca gtgctcagcc aaggtgcagg     1020

agtggagagt ttggacttta gacttcatct tcgctatgaa tttctgatgt taggaattca     1080

acctgtaata gataaattaa gggaacacga aaattcaaca ttagataggc atttagactt     1140

ttttgaaatg ctccgaaatg aagatgaact agaatttgcc aaaagatttg aactggttca     1200

catagacaca aaaagtgcaa ctcagatgtt tgagctgacc aggaagaggc tgacacatag     1260

tgaagcttac ccgcatttca tgtccatcct gcaccactgc ctccaaatgc cttacaagag     1320

gagtggcaac actgttcagt actggctact actagataga attatacagc agatagttat     1380

ccagaatgac aaaggacagg accctgactc cacacctttg gaaaacttta atattaagaa     1440

tgtcgtacga atgttggtta atgaaaatga agttaagcag tggaaagaac aagcggaaaa     1500

aatgagaaaa gagcacaatg agctacaaca gaaactggaa aagaaagaac gagaatgtga     1560

tgctaagact caagagaagg aagagatgat gcagacctta aataaaatga aagagaaact     1620

tgaaaaggag actactgagc ataagcaagt caagcagcag gtggcggacc tcacagcaca     1680

gctccatgag ctcagcagga gggccgtctg tgcttcaatc ccaggtggac cctcgcctgg     1740

agcaccagga gggccctttc cttcctctgt gcctggatct ctccttcctc ccccaccacc     1800

cccacctcta ccaggtggga tgcttccccc tccaccgcct cccctccctc caggtggccc     1860

tcctcctccc ccagggcctc ctcccttagg ggcaatcatg ccacctcctg gtgctccaat     1920

gggcctagca ctgaagaaga aaagcattcc tcagcccaca aatgccctga aatccttcaa     1980

ctggtctaaa ctgcccgaga acaaactgga aggaacagta tggaccgaaa ttgatgatac     2040

aaaagtcttc aaaattctag atcttgaaga cctggaaaga accttctctg cctatcaaag     2100

acagcagaaa gaagcagatg ccattgatga cactctgagt tccaaactta aagttaaaga     2160

gctttcggtg attgatggtc ggagagctca gaattgcaac atccttctat cgaggttgaa     2220

attatccaat gacgaaatca aacgggcaat tctaacaatg gacgaacagg aagatctgcc     2280

caaggacatg ttggaacagc tcttgaaatt tgttcctgaa aaaagtgaca ttgacctatt     2340

ggaggaacat aaacacgaac tggatcggat ggccaaggct gataggttcc tttttgagat     2400

gagccgaatt aatcactatc agcaaaggtt gcaatcgctg tacttcaaaa agaagtttgc     2460

agagcgtgtg gcagaagtga aacctaaagt ggaagcaatt cgttctggct cagaagaggt     2520

gtttaggagt ggtgccctca agcagttgct ggaggtggtt ttggcatttg gaaattatat     2580

gaataaaggt caaagaggga atgcatatgg attcaagata tctagcctaa acaaaattgc     2640

tgacacaaaa tccagcatcg acaaaaacat tacccttttg cactatctca tcactattgt     2700

ggaaaataag taccccagtg ttctcaatct aaatgaagaa ttgcgagata ttcctcaagc     2760

tgcgaaagta aacatgactg agctggacaa agaaataagt accttgagaa gtggcttgaa     2820

agcagtagag acagagctgg aatatcagaa gtctcagccc ccacagcccg gagataagtt     2880

tgtgtctgtt gtcagccagt tcatcacagt agccagcttc agcttctctg atgttgaaga     2940

ccttctagca gaagctaaag acctgtttac taaagcagtg aagcactttg gggaagaggc     3000

tggcaaaata caaccagatg agttctttgg catttttgat caatttcttc aagctgtgtc     3060

agaagccaaa caagaaaacg aaaatatgag aaagaaaaag gaggaagaag aacgtcgagc     3120

tcgcatggaa gctcagctca aagaacaacg tgaaagggaa cgtaaaatga gaaaagctaa     3180

agagaatagt gaagaaagcg gagagtttga tgaccttgtt tcagctttac gctcaggaga     3240

agtgtttgac aaagaccttt ctaaattgaa acggaatcgc aaacgtatta ccaaccagat     3300

gactgacagc agcagagaga gaccaatcac aaaacttaat ttctaatttt ccatgaatac     3360

ttttttttag aaagctcatt agcagccctc taaagtgact agaacgtttc attacactgc     3420

cttgcaatcc aaacagtggc aattttttcc ttcatctgtg agtgaatgtg tgaacgtgtg     3480

tatgtaaatg tatgtgtgta tatattaaaa aatgtatata gatgtctgag tgttgtctgg     3540

agacctatac gtatggttaa aaagatttat gttaatgtat gtgctccaaa acctttcgtg     3600

tatgcattca cattgagtgt ggctcatttt ctttccccga acgccatgac tgttcagaag     3660

cacaatacta tctcctgaaa gagataagag acattcccta gattcaaagg caaaacagaa     3720

gaaacaaaca aacaaacaaa aaaagcttgc aaaatatttt atggtttcca agcttgatat     3780

cctttaaaat tattttcatt gatggaactg gagttgttgg aaaaacatag atttaaaatg     3840

atttttgata gctgacattg tgatgttgat gtatcacatc agtaatagga ccagctttga     3900

atttctgaca ttggtgtggg gatacagtct gtaaatgttt attgagaaca tcttgcacac     3960

aatttgaatt atgtagaatg tcaatcaagt ttttgtatat ttaaaagttg gacatcaatt     4020

ttttcccctg atttcatcaa gttatctctg ccaagtgctc ttgataattt cttcagattt     4080

ttggaaaaaa acactatata aatgcaatcc atgctttttt taaagaacaa cattgccaga     4140

gtatgcttgt tctaacaata tagatatata aaccttaaaa ataataaaat atctcaccca     4200

agacttaaag gaagaattct ctgaagggat aaagattact aaaaaaaaaa aaaaaaaaaa     4260

aaaattaatg gggtgccttt ttgttatagt ttctattttc tgttttgtag gacaagctgc     4320

attttctgta aatataggtc tggactaaag gatacataaa gaatgcacaa aatgtcaaca     4380

tcagcagaga tgcccagatc tatttatctc taagtatatt tgaagtgatt gctgtttata     4440

tgttgtcatt ttaaaattgt gtgtcagtaa agctacctgt aaaatttcag tccaaaaaaa     4500

taaagctctc agggagacat gaataaaatc aatgaacatt agaaaataaa atatagatgc     4560

ttaccattaa cctaccaact cttaatatcc ttaaattatg tgatatataa agaggactgt     4620

tactttttta cttttttttt tttttttttt tttttttggc tttgctttat ttatttgtag     4680

ttgggggcta acgttttctc ttttctttct attgatcctg ttgtggttgg gtttcctgtg     4740

gagagagtag tttgtcctgt tgcactagaa cattatttac tcactaaatt gagtttttca     4800

gtcaattaac aaatatttat taagttccta ctatgtacca ggcatagtag ggctacaatg     4860

gtaagcaaga cagagtccct gcccccaaag agcttatatt ctaatgggga tattaaggga     4920

tgaatagaat accaatgtgt gcactgtaca ggaatcatac tatttaaaaa taatttgtat     4980

aaactataat gcttagcaca gatggcgagt tatctgtgct atgtgaaagc tgtgaaatag     5040

tgctctaaga gttgtcaaga gctgtggttt tacatctttt cctcattgca aatttagtga     5100

ctttctacac actatatgga aataaatgac tagcaaataa aacagtcata aatacaaagc     5160

agaggttgca ctcccccaat cccgagttaa cccaggtctg caataacacc atgttaaagg     5220

tgcagataga gacttggctc aaaaaggctt ggagatgagg aagattggaa tataatgatg     5280

gttttgtctg ttccttaact aaagtgcctc tatgtatatt cttttctatt tgtagcagga     5340

taaatttggt ctggctcagt tttggaactg tattttgaaa atggctttgt cttacagttt     5400

aaggaataga caggtggagg gaaagtcaca taaaggagca agtttgtgta gctgtccctc     5460

ttgccccttt taatcatcct cctttgatat ggccatcctg gtgggcctcc tttgccattt     5520

ccatttttgg tttctttccc tgaaaactgt gtgcaggtaa ttccatgtgc cattgttgaa     5580

aagaaaaaaa aaaaacaaaa aaaaaaccta ctttttagat tggtgctggt gtaagtagcc     5640

acttttctct cttgggtgtg tattttaaac tttttttgtt tttttaaatt aatgccaaaa     5700

agaaaatgca taatttgtaa acttaattat atgtcttata tcttattagc ttagtagttg     5760

gaaccactta gtctttaggt gcaagactgt tgttagatag tactgagaaa aaaaaagtat     5820

gtgttatgag actgtacatg tttttttaaa aatagcaata tgcaataaag agatgaattc     5880

attgggtgta                                                            5890


<210>  632
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  632

Met Ala Pro Arg Lys Arg Gly Gly Arg Gly Ile Ser Phe Ile Phe Cys 
1               5                   10                  15      


Cys Phe Arg Asn Asn Asp His Pro Glu Ile Thr Tyr Arg Leu Arg Asn 
            20                  25                  30          


Asp Ser Asn Phe Ala Leu Gln Thr Met Glu Pro Ala Leu Pro Met Pro 
        35                  40                  45              


Pro Val Glu Glu Leu Asp Val Met Phe Ser Glu Leu Val Asp Glu Leu 
    50                  55                  60                  


Asp Leu Thr Asp Lys His Arg Glu Ala Met Phe Ala Leu Pro Ala Glu 
65                  70                  75                  80  


Lys Lys Trp Gln Ile Tyr Cys Ser Lys Lys Lys Asp Gln Glu Glu Asn 
                85                  90                  95      


Lys Gly Ala Thr Ser Trp Pro Glu Phe Tyr Ile Asp Gln Leu Asn Ser 
            100                 105                 110         


Met Ala Ala Arg Lys Ser Leu Leu Ala Leu Glu Lys Glu Glu Glu Glu 
        115                 120                 125             


Glu Arg Ser Lys Thr Ile Glu Ser Leu Lys Thr Ala Leu Arg Thr Lys 
    130                 135                 140                 


Pro Met Arg Phe Val Thr Arg Phe Ile Asp Leu Asp Gly Leu Ser Cys 
145                 150                 155                 160 


Ile Leu Asn Phe Leu Lys Thr Met Asp Tyr Glu Thr Ser Glu Ser Arg 
                165                 170                 175     


Ile His Thr Ser Leu Ile Gly Cys Ile Lys Ala Leu Met Asn Asn Ser 
            180                 185                 190         


Gln Gly Arg Ala His Val Leu Ala His Ser Glu Ser Ile Asn Val Ile 
        195                 200                 205             


Ala Gln Ser Leu Ser Thr Glu Asn Ile Lys Thr Lys Val Ala Val Leu 
    210                 215                 220                 


Glu Ile Leu Gly Ala Val Cys Leu Val Pro Gly Gly His Lys Lys Val 
225                 230                 235                 240 


Leu Gln Ala Met Leu His Tyr Gln Lys Tyr Ala Ser Glu Arg Thr Arg 
                245                 250                 255     


Phe Gln Thr Leu Ile Asn Asp Leu Asp Lys Ser Thr Gly Arg Tyr Arg 
            260                 265                 270         


Asp Glu Val Ser Leu Lys Thr Ala Ile Met Ser Phe Ile Asn Ala Val 
        275                 280                 285             


Leu Ser Gln Gly Ala Gly Val Glu Ser Leu Asp Phe Arg Leu His Leu 
    290                 295                 300                 


Arg Tyr Glu Phe Leu Met Leu Gly Ile Gln Pro Val Ile Asp Lys Leu 
305                 310                 315                 320 


Arg Glu His Glu Asn Ser Thr Leu Asp Arg His Leu Asp Phe Phe Glu 
                325                 330                 335     


Met Leu Arg Asn Glu Asp Glu Leu Glu Phe Ala Lys Arg Phe Glu Leu 
            340                 345                 350         


Val His Ile Asp Thr Lys Ser Ala Thr Gln Met Phe Glu Leu Thr Arg 
        355                 360                 365             


Lys Arg Leu Thr His Ser Glu Ala Tyr Pro His Phe Met Ser Ile Leu 
    370                 375                 380                 


His His Cys Leu Gln Met Pro Tyr Lys Arg Ser Gly Asn Thr Val Gln 
385                 390                 395                 400 


Tyr Trp Leu Leu Leu Asp Arg Ile Ile Gln Gln Ile Val Ile Gln Asn 
                405                 410                 415     


Asp Lys Gly Gln Asp Pro Asp Ser Thr Pro Leu Glu Asn Phe Asn Ile 
            420                 425                 430         


Lys Asn Val Val Arg Met Leu Val Asn Glu Asn Glu Val Lys Gln Trp 
        435                 440                 445             


Lys Glu Gln Ala Glu Lys Met Arg Lys Glu His Asn Glu Leu Gln Gln 
    450                 455                 460                 


Lys Leu Glu Lys Lys Glu Arg Glu Cys Asp Ala Lys Thr Gln Glu Lys 
465                 470                 475                 480 


Glu Glu Met Met Gln Thr Leu Asn Lys Met Lys Glu Lys Leu Glu Lys 
                485                 490                 495     


Glu Thr Thr Glu His Lys Gln Val Lys Gln Gln Val Ala Asp Leu Thr 
            500                 505                 510         


Ala Gln Leu His Glu Leu Ser Arg Arg Ala Val Cys Ala Ser Ile Pro 
        515                 520                 525             


Gly Gly Pro Ser Pro Gly Ala Pro Gly Gly Pro Phe Pro Ser Ser Val 
    530                 535                 540                 


Pro Gly Ser Leu Leu Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly 
545                 550                 555                 560 


Met Leu Pro Pro Pro Pro Pro Pro Leu Pro Pro Gly Gly Pro Pro Pro 
                565                 570                 575     


Pro Pro Gly Pro Pro Pro Leu Gly Ala Ile Met Pro Pro Pro Gly Ala 
            580                 585                 590         


Pro Met Gly Leu Ala Leu Lys Lys Lys Ser Ile Pro Gln Pro Thr Asn 
        595                 600                 605             


Ala Leu Lys Ser Phe Asn Trp Ser Lys Leu Pro Glu Asn Lys Leu Glu 
    610                 615                 620                 


Gly Thr Val Trp Thr Glu Ile Asp Asp Thr Lys Val Phe Lys Ile Leu 
625                 630                 635                 640 


Asp Leu Glu Asp Leu Glu Arg Thr Phe Ser Ala Tyr Gln Arg Gln Gln 
                645                 650                 655     


Lys Glu Ala Asp Ala Ile Asp Asp Thr Leu Ser Ser Lys Leu Lys Val 
            660                 665                 670         


Lys Glu Leu Ser Val Ile Asp Gly Arg Arg Ala Gln Asn Cys Asn Ile 
        675                 680                 685             


Leu Leu Ser Arg Leu Lys Leu Ser Asn Asp Glu Ile Lys Arg Ala Ile 
    690                 695                 700                 


Leu Thr Met Asp Glu Gln Glu Asp Leu Pro Lys Asp Met Leu Glu Gln 
705                 710                 715                 720 


Leu Leu Lys Phe Val Pro Glu Lys Ser Asp Ile Asp Leu Leu Glu Glu 
                725                 730                 735     


His Lys His Glu Leu Asp Arg Met Ala Lys Ala Asp Arg Phe Leu Phe 
            740                 745                 750         


Glu Met Ser Arg Ile Asn His Tyr Gln Gln Arg Leu Gln Ser Leu Tyr 
        755                 760                 765             


Phe Lys Lys Lys Phe Ala Glu Arg Val Ala Glu Val Lys Pro Lys Val 
    770                 775                 780                 


Glu Ala Ile Arg Ser Gly Ser Glu Glu Val Phe Arg Ser Gly Ala Leu 
785                 790                 795                 800 


Lys Gln Leu Leu Glu Val Val Leu Ala Phe Gly Asn Tyr Met Asn Lys 
                805                 810                 815     


Gly Gln Arg Gly Asn Ala Tyr Gly Phe Lys Ile Ser Ser Leu Asn Lys 
            820                 825                 830         


Ile Ala Asp Thr Lys Ser Ser Ile Asp Lys Asn Ile Thr Leu Leu His 
        835                 840                 845             


Tyr Leu Ile Thr Ile Val Glu Asn Lys Tyr Pro Ser Val Leu Asn Leu 
    850                 855                 860                 


Asn Glu Glu Leu Arg Asp Ile Pro Gln Ala Ala Lys Val Asn Met Thr 
865                 870                 875                 880 


Glu Leu Asp Lys Glu Ile Ser Thr Leu Arg Ser Gly Leu Lys Ala Val 
                885                 890                 895     


Glu Thr Glu Leu Glu Tyr Gln Lys Ser Gln Pro Pro Gln Pro Gly Asp 
            900                 905                 910         


Lys Phe Val Ser Val Val Ser Gln Phe Ile Thr Val Ala Ser Phe Ser 
        915                 920                 925             


Phe Ser Asp Val Glu Asp Leu Leu Ala Glu Ala Lys Asp Leu Phe Thr 
    930                 935                 940                 


Lys Ala Val Lys His Phe Gly Glu Glu Ala Gly Lys Ile Gln Pro Asp 
945                 950                 955                 960 


Glu Phe Phe Gly Ile Phe Asp Gln Phe Leu Gln Ala Val Ser Glu Ala 
                965                 970                 975     


Lys Gln Glu Asn Glu Asn Met Arg Lys Lys Lys Glu Glu Glu Glu Arg 
            980                 985                 990         


Arg Ala Arg Met Glu Ala Gln Leu  Lys Glu Gln Arg Glu  Arg Glu Arg 
        995                 1000                 1005             


Lys Met  Arg Lys Ala Lys Glu  Asn Ser Glu Glu Ser  Gly Glu Phe 
    1010                 1015                 1020             


Asp Asp  Leu Val Ser Ala Leu  Arg Ser Gly Glu Val  Phe Asp Lys 
    1025                 1030                 1035             


Asp Leu  Ser Lys Leu Lys Arg  Asn Arg Lys Arg Ile  Thr Asn Gln 
    1040                 1045                 1050             


Met Thr  Asp Ser Ser Arg Glu  Arg Pro Ile Thr Lys  Leu Asn Phe 
    1055                 1060                 1065             


<210>  633
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  633
aaggtctctt cctgcctgag gatgaaaacc tgagggaaaa aggggactgg agccagttca       60

cgctgtggca gcaag                                                        75


<210>  634
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  634
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaa                                                        75


<210>  635
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  635
aaggtctctt cctgcctgag gatgaaaacc tgagggaaaa aggggactgg agccagttca       60

cgctgtggca gcaagccttg cctccccgat tgaaagagat gaaaagccag gaatcggctg      120

caggttccaa actagtcctt cggtgtgaaa                                       150


<210>  636
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  636

Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu Lys Gly Asp Trp 
1               5                   10                  15      


Ser Gln Phe Thr Leu Trp Gln Gln Ala Leu Pro Pro Arg Leu Lys Glu 
            20                  25                  30          


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
        35                  40                  45              


Glu 
    


<210>  637
<211>  139
<212>  DNA
<213>  Homo sapiens

<400>  637
agtctcaagc tctggtaggc aagtgcatgc agtgtgccta aaacctgcca gcagtacttt       60

tgagtttttt tttttgtttt gttttacttt agcatttatt attcatggat tgaagaaatc      120

aaaatggctg aagataaag                                                   139


<210>  638
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  638
agacaaagca tggaggacac aagaatggga ggaaaggcgg actctcagga acttcattct       60

tcacgtggtt tatggtgatt gcattgctgg gcgtctggac atctgtagct gtcgtttggt      120

ttgatcttgt tgactatgag gaagttctag                                       150


<210>  639
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  639
gaaaactagg aatctatgat gctgatggtg atggagattt tgatgtggat gatgccaaag       60

ttttattag                                                               69


<210>  640
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  640
gacttaaaga gagatctact tcagagccag cagtcccgcc agaagaggct gagccacaca       60

ctgagcccga ggagcaggtt cctgtggagg cag                                    93


<210>  641
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  641
aaccccagaa tatcgaagat gaagcaaaag aacaaattca gtcccttctc catgaaatgg       60

tacacgcaga acatg                                                        75


<210>  642
<211>  129
<212>  DNA
<213>  Homo sapiens

<400>  642
ttgagggaga agacttgcaa caagaagatg gacccacagg agaaccacaa caagaggatg       60

atgagtttct tatggcgact gatgtagatg atagatttga gaccctggaa cctgaagtat      120

ctcatgaag                                                              129


<210>  643
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  643
aaaccgagca tagttaccac gtggaagaga cag                                    33


<210>  644
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  644
tttcacaaga ctgtaatcag gatatggaag agatgatgtc tgagcaggaa aatccag          57


<210>  645
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  645
attccagtga accagtagta gaagatgaaa gattgcacca tgatacag                    48


<210>  646
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  646
atgatgtaac ataccaagtc tatgaggaac aag                                    33


<210>  647
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  647
cagtatatga acctctagaa aatgaaggga tagaaatcac ag                          42


<210>  648
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  648
aagtaactgc tccccctgag gataatcctg tagaagattc acaggtaatt gtagaag          57


<210>  649
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  649
aagtaagcat ttttcctgtg gaagaacagc aggaagtacc accag                       45


<210>  650
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  650
aaacaaatag aaaaacagat gatccagaac aaaaagcaaa ag                          42


<210>  651
<211>  86
<212>  DNA
<213>  Homo sapiens

<400>  651
ttaagaaaaa gaagcctaaa cttttaaata aatttgataa gactattaaa gctgaacttg       60

atgctgcaga aaaactccgt aaaagg                                            86


<210>  652
<211>  87
<212>  DNA
<213>  Homo sapiens

<400>  652
ggaaaaattg aggaagcagt gaatgcattt aaagaactag tacgcaaata ccctcagagt       60

ccacgagcaa gatatgggaa ggcgcag                                           87


<210>  653
<211>  151
<212>  DNA
<213>  Homo sapiens

<400>  653
tgtgaggatg atttggctga gaagaggaga agtaatgagg tgctacgtgg agccatcgag       60

acctaccaag aggtggccag cctacctgat gtccctgcag acctgctgaa gctgagtttg      120

aagcgtcgct cagacaggca acaatttcta g                                     151


<210>  654
<211>  137
<212>  DNA
<213>  Homo sapiens

<400>  654
gtcatatgag aggttccctg cttaccctgc agagattagt tcaactattt cccaatgata       60

cttccttaaa aaatgacctt ggcgtgggat acctcttgat aggagataat gacaatgcaa      120

agaaagttta tgaagag                                                     137


<210>  655
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  655
gtgctgagtg tgacacctaa tgatggcttt gctaaagtcc attatggctt catcctgaag       60

gcacagaaca aaattgctga gagcatccca tatttaaag                              99


<210>  656
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  656
gaaggaatag aatccggaga tcctggcact gatgatggga gattttattt ccacctgggg       60

gatgccatgc agagggttgg gaacaaagag                                        90


<210>  657
<211>  138
<212>  DNA
<213>  Homo sapiens

<400>  657
gcatataagt ggtatgagct tgggcacaag agaggacact ttgcatctgt ctggcaacgc       60

tcactctaca atgtgaatgg actgaaagca cagccttggt ggaccccaaa agaaacgggc      120

tacacagagt tagtaaag                                                    138


<210>  658
<211>  136
<212>  DNA
<213>  Homo sapiens

<400>  658
tctttagaaa gaaactggaa gttaatccga gatgaaggcc ttgcagtgat ggataaagcc       60

aaaggtctct tcctgcctga ggatgaaaac ctgagggaaa aaggggactg gagccagttc      120

acgctgtggc agcaag                                                      136


<210>  659
<211>  92
<212>  DNA
<213>  Homo sapiens

<400>  659
gaagaagaaa tgaaaatgcc tgcaaaggag ctcctaaaac ctgtacctta ctagaaaagt       60

tccccgagac aacaggatgc agaagaggac ag                                     92


<210>  660
<211>  134
<212>  DNA
<213>  Homo sapiens

<400>  660
atcaaatatt ccatcatgca ccccgggact cacgtgtggc cgcacacagg gcccacaaac       60

tgcaggctcc gaatgcacct gggcttggtg attcccaagg aaggctgcaa gattcgatgt      120

gccaacgaga ccaa                                                        134


<210>  661
<211>  2954
<212>  DNA
<213>  Homo sapiens

<400>  661
gacctgggag gaaggcaagg tgctcatctt tgatgactcc tttgagcacg aggtatggca       60

ggatgcctca tctttccggc tgatattcat cgtggatgtg tggcatccgg aactgacacc      120

acagcagaga cgcagccttc cagcaattta gcatgaattc atgcaagctt gggaaactct      180

ggagagaggc tgcctttctg gttccatctc cttgggtgtg aggatagaat ttcgaacacc      240

aagagtcaat tcccttgact tgcagcccga gtaattcaaa gcctcctcct agggtcagaa      300

gacactaaag ggaatatttg cctcgctgca attcatttag gaaacaccct gctgtgtgtc      360

atctcatgac agcactggtc ttctgccagt atttaaggtg aacatttgat agcttctacc      420

ttaccagcca aagatatttt ttccacatag aataggtcta attcaatgta taatgagaac      480

atatgtagaa actgtgaatg gattgcttta gtttgtaatt tttctatgca gttatatttt      540

tctagtgtag ctagactatt ttgtcatcat gtaccactac atttttgttt attttaatga      600

caagctgtat aaatgcttta cttctagcta tttaatggta gcattactgg ggaactcaga      660

cttccctctt ttaattcttc ttagtaaaag atactcatga aaaaagcagt tttattttcc      720

taacaaaaaa gaaagagctc attatgtcag tgtctatgaa ctgtacccat cccaactctc      780

aaatcgtttg gtttttttta tcttgattga gatcctcttc tcactatgct agtggtggag      840

atattgacaa aatcctattt ctttcaaaga ggaacttttc acaccgaaaa aagagcatgg      900

aattatttta tattgttata aaaatcccag atgcaaattt ttttaatgcc aattattaga      960

gcttctgggg aaaaagtata gttcacggaa ataaaactat gttctttcag ggttgggtgg     1020

ataggtggct gctagggtgt ctggctcctg gcggctttgc catccatgag gcaagggctg     1080

ggaacacagt gtctttgcct atggtagatc catgtgaatg tcaggaagcc agctcttcag     1140

tcttggagat gatttctgct acaattctgt agaaagatta aggatggcag agtaaaaggt     1200

taccaagaat gccaggatgt ttttcttggg cgtaggaggt ccagattact ttcctttttg     1260

atgaaagagt ttggaagact gtcccatctc tctggcttga gaaatctctg ccattttaaa     1320

catcactgtg aaatagcaat tattatcatc tgtatttagt tttaacatta cccacaacat     1380

agaaataata ggtaaaaatc gtcttgccta ctcattccaa agatgatcaa gtcattaatc     1440

tagcaaagta ttcatgtatc agattttgta tattttgaat caaagctaac taggaatgtt     1500

agatataaga atgtaatgat attcatgcac tgaattctaa gccaatatga acaaaaatgc     1560

tgcatgaatg gcacatatag gtcaccaaag ttcattcaca ggtagaaaaa acttgtgctt     1620

tcttttccat ctaaaaacaa aaggagactt tctttatctc atttaaagaa cagctctttg     1680

aaattgaaat tgaccctttt tgcttgacct taaggagatt agcttccagt agatgagttt     1740

gcaaaatact tttcctgttc ttttgttttg ctggtattga aaacatccca ctaaatcaga     1800

tgaagaggca tgggaggaaa aatatccaaa ttaattacta aaatcgagaa gagaaggcaa     1860

actcttgaaa agtaaaaagg tgtttgtgac cttcagtatt tattgaacag aggaaataac     1920

tgacaagggc aatacaattc aatgttcatg tagtaacatt catgtcactt gttgaatttg     1980

gttctcatat gtatattgca tacacataaa ttcaaactat aagtcgtcat ttttgagcca     2040

tcatcttaca ttcatgtaat gaaattatgg aagagagtaa aaactagctc ttaacttagt     2100

aaatataata tggtatttaa aatcaggtca ctacagtaag gttctaagta ttgccaattg     2160

aaaagctaga aatggtatta ctgttgcaaa gtgttgtcaa taattgactc caatagcatt     2220

gtaaatactt gtatcccaca actattttaa acccaagcaa taaaatggat tttctaattc     2280

acttcaattc tttatttctc ttacctatct atgtcttggt acataagaaa agtgtttcca     2340

tcactgcatt ggtagaatta tttcagtgtt attatttttg tgatttcgta tgtctacaca     2400

aaaatgaatt agtttaattt atattgtgat acagttgttt gagaaatatt tttaattctg     2460

tttcaacttt atttctccaa gtgtataata taaaaattac ttctgttatt gttctctacc     2520

aataggggaa aaaattaaaa cattagatcc attgagaaag agatgatgta ataaataatt     2580

aagattagta ataatattat caggggtgat tatgaccagt tgaataatct ctttcccttg     2640

aattatttag ctaacaaatt aactctccca aatatttaaa ataatgtaaa atcatatttt     2700

actgcccatt attaactaaa atatttttgt ttgactttga gcaccaactg gtaatactaa     2760

taaataccca tgtcatgcag atggctgggc gaataagaga tgtctaaaaa tatgcactgg     2820

tcttggaaaa catggcacaa gtaaggatat catatatgat gtctgtttat tttatgtctg     2880

atttcttttg aatgagtagt tggggactcc atttctaagg agactaggta aataaaatga     2940

cctttgacat ttca                                                       2954


<210>  662
<211>  5116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of ASPH

<400>  662
agtctcaagc tctggtaggc aagtgcatgc agtgtgccta aaacctgcca gcagtacttt       60

tgagtttttt tttttgtttt gttttacttt agcatttatt attcatggat tgaagaaatc      120

aaaatggctg aagataaaga gacaaagcat ggaggacaca agaatgggag gaaaggcgga      180

ctctcaggaa cttcattctt cacgtggttt atggtgattg cattgctggg cgtctggaca      240

tctgtagctg tcgtttggtt tgatcttgtt gactatgagg aagttctagg aaaactagga      300

atctatgatg ctgatggtga tggagatttt gatgtggatg atgccaaagt tttattagga      360

cttaaagaga gatctacttc agagccagca gtcccgccag aagaggctga gccacacact      420

gagcccgagg agcaggttcc tgtggaggca gaaccccaga atatcgaaga tgaagcaaaa      480

gaacaaattc agtcccttct ccatgaaatg gtacacgcag aacatgttga gggagaagac      540

ttgcaacaag aagatggacc cacaggagaa ccacaacaag aggatgatga gtttcttatg      600

gcgactgatg tagatgatag atttgagacc ctggaacctg aagtatctca tgaagaaacc      660

gagcatagtt accacgtgga agagacagtt tcacaagact gtaatcagga tatggaagag      720

atgatgtctg agcaggaaaa tccagattcc agtgaaccag tagtagaaga tgaaagattg      780

caccatgata cagatgatgt aacataccaa gtctatgagg aacaagcagt atatgaacct      840

ctagaaaatg aagggataga aatcacagaa gtaactgctc cccctgagga taatcctgta      900

gaagattcac aggtaattgt agaagaagta agcatttttc ctgtggaaga acagcaggaa      960

gtaccaccag aaacaaatag aaaaacagat gatccagaac aaaaagcaaa agttaagaaa     1020

aagaagccta aacttttaaa taaatttgat aagactatta aagctgaact tgatgctgca     1080

gaaaaactcc gtaaaagggg aaaaattgag gaagcagtga atgcatttaa agaactagta     1140

cgcaaatacc ctcagagtcc acgagcaaga tatgggaagg cgcagtgtga ggatgatttg     1200

gctgagaaga ggagaagtaa tgaggtgcta cgtggagcca tcgagaccta ccaagaggtg     1260

gccagcctac ctgatgtccc tgcagacctg ctgaagctga gtttgaagcg tcgctcagac     1320

aggcaacaat ttctaggtca tatgagaggt tccctgctta ccctgcagag attagttcaa     1380

ctatttccca atgatacttc cttaaaaaat gaccttggcg tgggatacct cttgatagga     1440

gataatgaca atgcaaagaa agtttatgaa gaggtgctga gtgtgacacc taatgatggc     1500

tttgctaaag tccattatgg cttcatcctg aaggcacaga acaaaattgc tgagagcatc     1560

ccatatttaa aggaaggaat agaatccgga gatcctggca ctgatgatgg gagattttat     1620

ttccacctgg gggatgccat gcagagggtt gggaacaaag aggcatataa gtggtatgag     1680

cttgggcaca agagaggaca ctttgcatct gtctggcaac gctcactcta caatgtgaat     1740

ggactgaaag cacagccttg gtggacccca aaagaaacgg gctacacaga gttagtaaag     1800

tctttagaaa gaaactggaa gttaatccga gatgaaggcc ttgcagtgat ggataaagcc     1860

aaaggtctct tcctgcctga ggatgaaaac ctgagggaaa aaggggactg gagccagttc     1920

acgctgtggc agcaaggaag aagaaatgaa aatgcctgca aaggagctcc taaaacctgt     1980

accttactag aaaagttccc cgagacaaca ggatgcagaa gaggacagat caaatattcc     2040

atcatgcacc ccgggactca cgtgtggccg cacacagggc ccacaaactg caggctccga     2100

atgcacctgg gcttggtgat tcccaaggaa ggctgcaaga ttcgatgtgc caacgagacc     2160

aagacctggg aggaaggcaa ggtgctcatc tttgatgact cctttgagca cgaggtatgg     2220

caggatgcct catctttccg gctgatattc atcgtggatg tgtggcatcc ggaactgaca     2280

ccacagcaga gacgcagcct tccagcaatt tagcatgaat tcatgcaagc ttgggaaact     2340

ctggagagag gctgcctttc tggttccatc tccttgggtg tgaggataga atttcgaaca     2400

ccaagagtca attcccttga cttgcagccc gagtaattca aagcctcctc ctagggtcag     2460

aagacactaa agggaatatt tgcctcgctg caattcattt aggaaacacc ctgctgtgtg     2520

tcatctcatg acagcactgg tcttctgcca gtatttaagg tgaacatttg atagcttcta     2580

ccttaccagc caaagatatt ttttccacat agaataggtc taattcaatg tataatgaga     2640

acatatgtag aaactgtgaa tggattgctt tagtttgtaa tttttctatg cagttatatt     2700

tttctagtgt agctagacta ttttgtcatc atgtaccact acatttttgt ttattttaat     2760

gacaagctgt ataaatgctt tacttctagc tatttaatgg tagcattact ggggaactca     2820

gacttccctc ttttaattct tcttagtaaa agatactcat gaaaaaagca gttttatttt     2880

cctaacaaaa aagaaagagc tcattatgtc agtgtctatg aactgtaccc atcccaactc     2940

tcaaatcgtt tggttttttt tatcttgatt gagatcctct tctcactatg ctagtggtgg     3000

agatattgac aaaatcctat ttctttcaaa gaggaacttt tcacaccgaa aaaagagcat     3060

ggaattattt tatattgtta taaaaatccc agatgcaaat ttttttaatg ccaattatta     3120

gagcttctgg ggaaaaagta tagttcacgg aaataaaact atgttctttc agggttgggt     3180

ggataggtgg ctgctagggt gtctggctcc tggcggcttt gccatccatg aggcaagggc     3240

tgggaacaca gtgtctttgc ctatggtaga tccatgtgaa tgtcaggaag ccagctcttc     3300

agtcttggag atgatttctg ctacaattct gtagaaagat taaggatggc agagtaaaag     3360

gttaccaaga atgccaggat gtttttcttg ggcgtaggag gtccagatta ctttcctttt     3420

tgatgaaaga gtttggaaga ctgtcccatc tctctggctt gagaaatctc tgccatttta     3480

aacatcactg tgaaatagca attattatca tctgtattta gttttaacat tacccacaac     3540

atagaaataa taggtaaaaa tcgtcttgcc tactcattcc aaagatgatc aagtcattaa     3600

tctagcaaag tattcatgta tcagattttg tatattttga atcaaagcta actaggaatg     3660

ttagatataa gaatgtaatg atattcatgc actgaattct aagccaatat gaacaaaaat     3720

gctgcatgaa tggcacatat aggtcaccaa agttcattca caggtagaaa aaacttgtgc     3780

tttcttttcc atctaaaaac aaaaggagac tttctttatc tcatttaaag aacagctctt     3840

tgaaattgaa attgaccctt tttgcttgac cttaaggaga ttagcttcca gtagatgagt     3900

ttgcaaaata cttttcctgt tcttttgttt tgctggtatt gaaaacatcc cactaaatca     3960

gatgaagagg catgggagga aaaatatcca aattaattac taaaatcgag aagagaaggc     4020

aaactcttga aaagtaaaaa ggtgtttgtg accttcagta tttattgaac agaggaaata     4080

actgacaagg gcaatacaat tcaatgttca tgtagtaaca ttcatgtcac ttgttgaatt     4140

tggttctcat atgtatattg catacacata aattcaaact ataagtcgtc atttttgagc     4200

catcatctta cattcatgta atgaaattat ggaagagagt aaaaactagc tcttaactta     4260

gtaaatataa tatggtattt aaaatcaggt cactacagta aggttctaag tattgccaat     4320

tgaaaagcta gaaatggtat tactgttgca aagtgttgtc aataattgac tccaatagca     4380

ttgtaaatac ttgtatccca caactatttt aaacccaagc aataaaatgg attttctaat     4440

tcacttcaat tctttatttc tcttacctat ctatgtcttg gtacataaga aaagtgtttc     4500

catcactgca ttggtagaat tatttcagtg ttattatttt tgtgatttcg tatgtctaca     4560

caaaaatgaa ttagtttaat ttatattgtg atacagttgt ttgagaaata tttttaattc     4620

tgtttcaact ttatttctcc aagtgtataa tataaaaatt acttctgtta ttgttctcta     4680

ccaatagggg aaaaaattaa aacattagat ccattgagaa agagatgatg taataaataa     4740

ttaagattag taataatatt atcaggggtg attatgacca gttgaataat ctctttccct     4800

tgaattattt agctaacaaa ttaactctcc caaatattta aaataatgta aaatcatatt     4860

ttactgccca ttattaacta aaatattttt gtttgacttt gagcaccaac tggtaatact     4920

aataaatacc catgtcatgc agatggctgg gcgaataaga gatgtctaaa aatatgcact     4980

ggtcttggaa aacatggcac aagtaaggat atcatatatg atgtctgttt attttatgtc     5040

tgatttcttt tgaatgagta gttggggact ccatttctaa ggagactagg taaataaaat     5100

gacctttgac atttca                                                     5116


<210>  663
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  663

Met Ala Glu Asp Lys 
1               5   


<210>  664
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  664

Thr Lys His Gly Gly His Lys Asn Gly Arg Lys Gly Gly Leu Ser Gly 
1               5                   10                  15      


Thr Ser Phe Phe Thr Trp Phe Met Val Ile Ala Leu Leu Gly Val Trp 
            20                  25                  30          


Thr Ser Val Ala Val Val Trp Phe Asp Leu Val Asp Tyr Glu Glu Val 
        35                  40                  45              


Leu 
    


<210>  665
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  665

Lys Leu Gly Ile Tyr Asp Ala Asp Gly Asp Gly Asp Phe Asp Val Asp 
1               5                   10                  15      


Asp Ala Lys Val Leu Leu 
            20          


<210>  666
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  666

Leu Lys Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala 
1               5                   10                  15      


Glu Pro His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala 
            20                  25                  30  


<210>  667
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  667

Pro Gln Asn Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu 
1               5                   10                  15      


His Glu Met Val His Ala Glu His 
            20                  


<210>  668
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  668

Glu Gly Glu Asp Leu Gln Gln Glu Asp Gly Pro Thr Gly Glu Pro Gln 
1               5                   10                  15      


Gln Glu Asp Asp Glu Phe Leu Met Ala Thr Asp Val Asp Asp Arg Phe 
            20                  25                  30          


Glu Thr Leu Glu Pro Glu Val Ser His Glu 
        35                  40          


<210>  669
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  669

Thr Glu His Ser Tyr His Val Glu Glu Thr 
1               5                   10  


<210>  670
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  670

Ser Gln Asp Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu 
1               5                   10                  15      


Asn Pro 
        


<210>  671
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  671

Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr 
1               5                   10                  15  


<210>  672
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  672

Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln 
1               5                   10  


<210>  673
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  673

Val Tyr Glu Pro Leu Glu Asn Glu Gly Ile Glu Ile Thr 
1               5                   10              


<210>  674
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  674

Val Thr Ala Pro Pro Glu Asp Asn Pro Val Glu Asp Ser Gln Val Ile 
1               5                   10                  15      


Val Glu 
        


<210>  675
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  675

Val Ser Ile Phe Pro Val Glu Glu Gln Gln Glu Val Pro Pro 
1               5                   10                  


<210>  676
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  676

Thr Asn Arg Lys Thr Asp Asp Pro Glu Gln Lys Ala Lys 
1               5                   10              


<210>  677
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  677

Lys Lys Lys Lys Pro Lys Leu Leu Asn Lys Phe Asp Lys Thr Ile Lys 
1               5                   10                  15      


Ala Glu Leu Asp Ala Ala Glu Lys Leu Arg Lys Arg 
            20                  25              


<210>  678
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  678

Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys Glu Leu Val Arg Lys 
1               5                   10                  15      


Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys Ala Gln 
            20                  25                  


<210>  679
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  679

Cys Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val Leu Arg 
1               5                   10                  15      


Gly Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp Val Pro 
            20                  25                  30          


Ala Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg Gln Gln 
        35                  40                  45              


Phe Leu 
    50  


<210>  680
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  680

His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg Leu Val Gln Leu Phe 
1               5                   10                  15      


Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly Val Gly Tyr Leu Leu 
            20                  25                  30          


Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr Glu Glu 
        35                  40                  45  


<210>  681
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  681

Val Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His Tyr Gly 
1               5                   10                  15      


Phe Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro Tyr Leu 
            20                  25                  30          


Lys 
    


<210>  682
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  682

Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly Arg Phe Tyr 
1               5                   10                  15      


Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys Glu 
            20                  25                  30  


<210>  683
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  683

Ala Tyr Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala Ser 
1               5                   10                  15      


Val Trp Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln Pro 
            20                  25                  30          


Trp Trp Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys 
        35                  40                  45      


<210>  684
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  684

Ser Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val 
1               5                   10                  15      


Met Asp Lys Ala Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg 
            20                  25                  30          


Glu Lys Gly Asp Trp Ser Gln Phe Thr Leu Trp Gln Gln 
        35                  40                  45  


<210>  685
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  685

Arg Arg Asn Glu Asn Ala Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu 
1               5                   10                  15      


Leu Glu Lys Phe Pro Glu Thr Thr Gly Cys Arg Arg Gly Gln 
            20                  25                  30  


<210>  686
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  686

Ile Lys Tyr Ser Ile Met His Pro Gly Thr His Val Trp Pro His Thr 
1               5                   10                  15      


Gly Pro Thr Asn Cys Arg Leu Arg Met His Leu Gly Leu Val Ile Pro 
            20                  25                  30          


Lys Glu Gly Cys Lys Ile Arg Cys Ala Asn Glu Thr 
        35                  40                  


<210>  687
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  687

Thr Trp Glu Glu Gly Lys Val Leu Ile Phe Asp Asp Ser Phe Glu His 
1               5                   10                  15      


Glu Val Trp Gln Asp Ala Ser Ser Phe Arg Leu Ile Phe Ile Val Asp 
            20                  25                  30          


Val Trp His Pro Glu Leu Thr Pro Gln Gln Arg Arg Ser Leu Pro Ala 
        35                  40                  45              


Ile 
    


<210>  688
<211>  729
<212>  PRT
<213>  Homo sapiens

<400>  688

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp 
    50                  55                  60                  


Gly Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu 
65                  70                  75                  80  


Lys Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu 
                85                  90                  95      


Pro His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln 
            100                 105                 110         


Asn Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu 
        115                 120                 125             


Met Val His Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp 
    130                 135                 140                 


Gly Pro Thr Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala 
145                 150                 155                 160 


Thr Asp Val Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His 
                165                 170                 175     


Glu Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp 
            180                 185                 190         


Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp 
        195                 200                 205             


Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp 
    210                 215                 220                 


Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu 
225                 230                 235                 240 


Glu Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp 
                245                 250                 255     


Asn Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe 
            260                 265                 270         


Pro Val Glu Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr 
        275                 280                 285             


Asp Asp Pro Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu 
    290                 295                 300                 


Leu Asn Lys Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys 
                325                 330                 335     


Glu Leu Val Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys 
            340                 345                 350         


Ala Gln Cys Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val 
        355                 360                 365             


Leu Arg Gly Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp 
    370                 375                 380                 


Val Pro Ala Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg 
385                 390                 395                 400 


Gln Gln Phe Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg 
                405                 410                 415     


Leu Val Gln Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly 
            420                 425                 430         


Val Gly Tyr Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr 
        435                 440                 445             


Glu Glu Val Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His 
    450                 455                 460                 


Tyr Gly Phe Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro 
465                 470                 475                 480 


Tyr Leu Lys Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly 
                485                 490                 495     


Arg Phe Tyr Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys 
            500                 505                 510         


Glu Ala Tyr Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala 
        515                 520                 525             


Ser Val Trp Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln 
    530                 535                 540                 


Pro Trp Trp Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser 
545                 550                 555                 560 


Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met 
                565                 570                 575     


Asp Lys Ala Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu 
            580                 585                 590         


Lys Gly Asp Trp Ser Gln Phe Thr Leu Trp Gln Gln Gly Arg Arg Asn 
        595                 600                 605             


Glu Asn Ala Cys Lys Gly Ala Pro Lys Thr Cys Thr Leu Leu Glu Lys 
    610                 615                 620                 


Phe Pro Glu Thr Thr Gly Cys Arg Arg Gly Gln Ile Lys Tyr Ser Ile 
625                 630                 635                 640 


Met His Pro Gly Thr His Val Trp Pro His Thr Gly Pro Thr Asn Cys 
                645                 650                 655     


Arg Leu Arg Met His Leu Gly Leu Val Ile Pro Lys Glu Gly Cys Lys 
            660                 665                 670         


Ile Arg Cys Ala Asn Glu Thr Lys Thr Trp Glu Glu Gly Lys Val Leu 
        675                 680                 685             


Ile Phe Asp Asp Ser Phe Glu His Glu Val Trp Gln Asp Ala Ser Ser 
    690                 695                 700                 


Phe Arg Leu Ile Phe Ile Val Asp Val Trp His Pro Glu Leu Thr Pro 
705                 710                 715                 720 


Gln Gln Arg Arg Ser Leu Pro Ala Ile 
                725                 


<210>  689
<211>  1936
<212>  DNA
<213>  Homo sapiens

<400>  689
agtctcaagc tctggtaggc aagtgcatgc agtgtgccta aaacctgcca gcagtacttt       60

tgagtttttt tttttgtttt gttttacttt agcatttatt attcatggat tgaagaaatc      120

aaaatggctg aagataaaga gacaaagcat ggaggacaca agaatgggag gaaaggcgga      180

ctctcaggaa cttcattctt cacgtggttt atggtgattg cattgctggg cgtctggaca      240

tctgtagctg tcgtttggtt tgatcttgtt gactatgagg aagttctagg aaaactagga      300

atctatgatg ctgatggtga tggagatttt gatgtggatg atgccaaagt tttattagga      360

cttaaagaga gatctacttc agagccagca gtcccgccag aagaggctga gccacacact      420

gagcccgagg agcaggttcc tgtggaggca gaaccccaga atatcgaaga tgaagcaaaa      480

gaacaaattc agtcccttct ccatgaaatg gtacacgcag aacatgttga gggagaagac      540

ttgcaacaag aagatggacc cacaggagaa ccacaacaag aggatgatga gtttcttatg      600

gcgactgatg tagatgatag atttgagacc ctggaacctg aagtatctca tgaagaaacc      660

gagcatagtt accacgtgga agagacagtt tcacaagact gtaatcagga tatggaagag      720

atgatgtctg agcaggaaaa tccagattcc agtgaaccag tagtagaaga tgaaagattg      780

caccatgata cagatgatgt aacataccaa gtctatgagg aacaagcagt atatgaacct      840

ctagaaaatg aagggataga aatcacagaa gtaactgctc cccctgagga taatcctgta      900

gaagattcac aggtaattgt agaagaagta agcatttttc ctgtggaaga acagcaggaa      960

gtaccaccag aaacaaatag aaaaacagat gatccagaac aaaaagcaaa agttaagaaa     1020

aagaagccta aacttttaaa taaatttgat aagactatta aagctgaact tgatgctgca     1080

gaaaaactcc gtaaaagggg aaaaattgag gaagcagtga atgcatttaa agaactagta     1140

cgcaaatacc ctcagagtcc acgagcaaga tatgggaagg cgcagtgtga ggatgatttg     1200

gctgagaaga ggagaagtaa tgaggtgcta cgtggagcca tcgagaccta ccaagaggtg     1260

gccagcctac ctgatgtccc tgcagacctg ctgaagctga gtttgaagcg tcgctcagac     1320

aggcaacaat ttctaggtca tatgagaggt tccctgctta ccctgcagag attagttcaa     1380

ctatttccca atgatacttc cttaaaaaat gaccttggcg tgggatacct cttgatagga     1440

gataatgaca atgcaaagaa agtttatgaa gaggtgctga gtgtgacacc taatgatggc     1500

tttgctaaag tccattatgg cttcatcctg aaggcacaga acaaaattgc tgagagcatc     1560

ccatatttaa aggaaggaat agaatccgga gatcctggca ctgatgatgg gagattttat     1620

ttccacctgg gggatgccat gcagagggtt gggaacaaag aggcatataa gtggtatgag     1680

cttgggcaca agagaggaca ctttgcatct gtctggcaac gctcactcta caatgtgaat     1740

ggactgaaag cacagccttg gtggacccca aaagaaacgg gctacacaga gttagtaaag     1800

tctttagaaa gaaactggaa gttaatccga gatgaaggcc ttgcagtgat ggataaagcc     1860

aaaggtctct tcctgcctga ggatgaaaac ctgagggaaa aaggggactg gagccagttc     1920

acgctgtggc agcaag                                                     1936


<210>  690
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  690

Met Ala Glu Asp Lys Glu Thr Lys His Gly Gly His Lys Asn Gly Arg 
1               5                   10                  15      


Lys Gly Gly Leu Ser Gly Thr Ser Phe Phe Thr Trp Phe Met Val Ile 
            20                  25                  30          


Ala Leu Leu Gly Val Trp Thr Ser Val Ala Val Val Trp Phe Asp Leu 
        35                  40                  45              


Val Asp Tyr Glu Glu Val Leu Gly Lys Leu Gly Ile Tyr Asp Ala Asp 
    50                  55                  60                  


Gly Asp Gly Asp Phe Asp Val Asp Asp Ala Lys Val Leu Leu Gly Leu 
65                  70                  75                  80  


Lys Glu Arg Ser Thr Ser Glu Pro Ala Val Pro Pro Glu Glu Ala Glu 
                85                  90                  95      


Pro His Thr Glu Pro Glu Glu Gln Val Pro Val Glu Ala Glu Pro Gln 
            100                 105                 110         


Asn Ile Glu Asp Glu Ala Lys Glu Gln Ile Gln Ser Leu Leu His Glu 
        115                 120                 125             


Met Val His Ala Glu His Val Glu Gly Glu Asp Leu Gln Gln Glu Asp 
    130                 135                 140                 


Gly Pro Thr Gly Glu Pro Gln Gln Glu Asp Asp Glu Phe Leu Met Ala 
145                 150                 155                 160 


Thr Asp Val Asp Asp Arg Phe Glu Thr Leu Glu Pro Glu Val Ser His 
                165                 170                 175     


Glu Glu Thr Glu His Ser Tyr His Val Glu Glu Thr Val Ser Gln Asp 
            180                 185                 190         


Cys Asn Gln Asp Met Glu Glu Met Met Ser Glu Gln Glu Asn Pro Asp 
        195                 200                 205             


Ser Ser Glu Pro Val Val Glu Asp Glu Arg Leu His His Asp Thr Asp 
    210                 215                 220                 


Asp Val Thr Tyr Gln Val Tyr Glu Glu Gln Ala Val Tyr Glu Pro Leu 
225                 230                 235                 240 


Glu Asn Glu Gly Ile Glu Ile Thr Glu Val Thr Ala Pro Pro Glu Asp 
                245                 250                 255     


Asn Pro Val Glu Asp Ser Gln Val Ile Val Glu Glu Val Ser Ile Phe 
            260                 265                 270         


Pro Val Glu Glu Gln Gln Glu Val Pro Pro Glu Thr Asn Arg Lys Thr 
        275                 280                 285             


Asp Asp Pro Glu Gln Lys Ala Lys Val Lys Lys Lys Lys Pro Lys Leu 
    290                 295                 300                 


Leu Asn Lys Phe Asp Lys Thr Ile Lys Ala Glu Leu Asp Ala Ala Glu 
305                 310                 315                 320 


Lys Leu Arg Lys Arg Gly Lys Ile Glu Glu Ala Val Asn Ala Phe Lys 
                325                 330                 335     


Glu Leu Val Arg Lys Tyr Pro Gln Ser Pro Arg Ala Arg Tyr Gly Lys 
            340                 345                 350         


Ala Gln Cys Glu Asp Asp Leu Ala Glu Lys Arg Arg Ser Asn Glu Val 
        355                 360                 365             


Leu Arg Gly Ala Ile Glu Thr Tyr Gln Glu Val Ala Ser Leu Pro Asp 
    370                 375                 380                 


Val Pro Ala Asp Leu Leu Lys Leu Ser Leu Lys Arg Arg Ser Asp Arg 
385                 390                 395                 400 


Gln Gln Phe Leu Gly His Met Arg Gly Ser Leu Leu Thr Leu Gln Arg 
                405                 410                 415     


Leu Val Gln Leu Phe Pro Asn Asp Thr Ser Leu Lys Asn Asp Leu Gly 
            420                 425                 430         


Val Gly Tyr Leu Leu Ile Gly Asp Asn Asp Asn Ala Lys Lys Val Tyr 
        435                 440                 445             


Glu Glu Val Leu Ser Val Thr Pro Asn Asp Gly Phe Ala Lys Val His 
    450                 455                 460                 


Tyr Gly Phe Ile Leu Lys Ala Gln Asn Lys Ile Ala Glu Ser Ile Pro 
465                 470                 475                 480 


Tyr Leu Lys Glu Gly Ile Glu Ser Gly Asp Pro Gly Thr Asp Asp Gly 
                485                 490                 495     


Arg Phe Tyr Phe His Leu Gly Asp Ala Met Gln Arg Val Gly Asn Lys 
            500                 505                 510         


Glu Ala Tyr Lys Trp Tyr Glu Leu Gly His Lys Arg Gly His Phe Ala 
        515                 520                 525             


Ser Val Trp Gln Arg Ser Leu Tyr Asn Val Asn Gly Leu Lys Ala Gln 
    530                 535                 540                 


Pro Trp Trp Thr Pro Lys Glu Thr Gly Tyr Thr Glu Leu Val Lys Ser 
545                 550                 555                 560 


Leu Glu Arg Asn Trp Lys Leu Ile Arg Asp Glu Gly Leu Ala Val Met 
                565                 570                 575     


Asp Lys Ala Lys Gly Leu Phe Leu Pro Glu Asp Glu Asn Leu Arg Glu 
            580                 585                 590         


Lys Gly Asp Trp Ser Gln Phe Thr Leu Trp Gln Gln 
        595                 600                 


<210>  691
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  691
cctcctgtac tccaggctcc acctgcatcg accgtgtggc ctccttctct tgcatgtgcc       60

cagaggggaa ggcag                                                        75


<210>  692
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  692
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatg                                                        75


<210>  693
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  693
cctcctgtac tccaggctcc acctgcatcg accgtgtggc ctccttctct tgcatgtgcc       60

cagaggggaa ggcagctaca tctacatcca ccactgggac aagccatctt gtaaaatgtg      120

cggagaagga gaaaactttc tgtgtgaatg                                       150


<210>  694
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  694

Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg Val Ala Ser Phe Ser 
1               5                   10                  15      


Cys Met Cys Pro Glu Gly Lys Ala Ala Thr Ser Thr Ser Thr Thr Gly 
            20                  25                  30          


Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val 
        35                  40                  45              


Asn 
    


<210>  695
<211>  329
<212>  DNA
<213>  Homo sapiens

<400>  695
aggctgcttc gttgcacacc cgagaaagtt tcagccaaac ttcgggcggc ggctgaggcg       60

gcggccgagg agcggcggac tcggggcgcg gggagtcgag gcatttgcgc ctgggcttcg      120

gagcgtagcg ccagggcctg agcctttgaa gcaggaggag gggaggagag agtggggctc      180

ctctatcggg accccctccc catgtggatc tgcccaggcg gcggcggcgg cggcggagga      240

ggaggcgacc gagaagatgc ccgccctgcg ccccgctctg ctgtgggcgc tgctggcgct      300

ctggctgtgc tgcgcggccc ccgcgcatg                                        329


<210>  696
<211>  82
<212>  DNA
<213>  Homo sapiens

<400>  696
cattgcagtg tcgagatggc tatgaaccct gtgtaaatga aggaatgtgt gttacctacc       60

acaatggcac aggatactgc aa                                                82


<210>  697
<211>  260
<212>  DNA
<213>  Homo sapiens

<400>  697
atgtccagaa ggcttcttgg gggaatattg tcaacatcga gacccctgtg agaagaaccg       60

ctgccagaat ggtgggactt gtgtggccca ggccatgctg gggaaagcca cgtgccgatg      120

tgcctcaggg tttacaggag aggactgcca gtactcaaca tctcatccat gctttgtgtc      180

tcgaccctgc ctgaatggcg gcacatgcca tatgctcagc cgggatacct atgagtgcac      240

ctgtcaagtc gggtttacag                                                  260


<210>  698
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  698
gtaaggagtg ccaatggacg gatgcctgcc tgtctcatcc ctgtgcaaat ggaagtacct       60

gtaccactgt ggccaaccag ttctcctgca aatgcctcac aggcttcaca gggcagaaat      120

gtgagactga tgtcaatgag tgtgacattc caggacactg ccagcatggt ggcacctgcc      180

tcaacctgcc tggttcctac cagtgccagt gccctcaggg cttcacaggc cagtactgtg      240

acagcctgta tgtgccctgt gcaccctcac cttgtgtcaa tggaggcacc tgtcggcaga      300

ctggtgactt cacttttgag tgcaactgcc ttccag                                336


<210>  699
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  699
gttttgaagg gagcacctgt gagaggaata ttgatgactg ccctaaccac aggtgtcaga       60

atggaggggt ttgtgtggat ggggtcaaca cttacaactg ccgctgtccc ccacaatgga      120

cag                                                                    123


<210>  700
<211>  234
<212>  DNA
<213>  Homo sapiens

<400>  700
gacagttctg cacagaggat gtggatgaat gcctgctgca gcccaatgcc tgtcaaaatg       60

ggggcacctg tgccaaccgc aatggaggct atggctgtgt atgtgtcaac ggctggagtg      120

gagatgactg cagtgagaac attgatgatt gtgccttcgc ctcctgtact ccaggctcca      180

cctgcatcga ccgtgtggcc tccttctctt gcatgtgccc agaggggaag gcag            234


<210>  701
<211>  156
<212>  DNA
<213>  Homo sapiens

<400>  701
gtctcctgtg tcatctggat gatgcatgca tcagcaatcc ttgccacaag ggggcactgt       60

gtgacaccaa ccccctaaat gggcaatata tttgcacctg cccacaaggc tacaaagggg      120

ctgactgcac agaagatgtg gatgaatgtg ccatgg                                156


<210>  702
<211>  9905
<212>  DNA
<213>  Homo sapiens

<400>  702
ccaatagcaa tccttgtgag catgcaggaa aatgtgtgaa cacggatggc gccttccact       60

gtgagtgtct gaagggttat gcaggacctc gttgtgagat ggacatcaat gagtgccatt      120

cagacccctg ccagaatgat gctacctgtc tggataagat tggaggcttc acatgtctgt      180

gcatgccagg tttcaaaggt gtgcattgtg aattagaaat aaatgaatgt cagagcaacc      240

cttgtgtgaa caatgggcag tgtgtggata aagtcaatcg tttccagtgc ctgtgtcctc      300

ctggtttcac tgggccagtt tgccagattg atattgatga ctgttccagt actccgtgtc      360

tgaatggggc aaagtgtatc gatcacccga atggctatga atgccagtgt gccacaggtt      420

tcactggtgt gttgtgtgag gagaacattg acaactgtga ccccgatcct tgccaccatg      480

gtcagtgtca ggatggtatt gattcctaca cctgcatctg caatcccggg tacatgggcg      540

ccatctgcag tgaccagatt gatgaatgtt acagcagccc ttgcctgaac gatggtcgct      600

gcattgacct ggtcaatggc taccagtgca actgccagcc aggcacgtca ggggttaatt      660

gtgaaattaa ttttgatgac tgtgcaagta acccttgtat ccatggaatc tgtatggatg      720

gcattaatcg ctacagttgt gtctgctcac caggattcac agggcagaga tgtaacattg      780

acattgatga gtgtgcctcc aatccctgtc gcaagggtgc aacatgtatc aacggtgtga      840

atggtttccg ctgtatatgc cccgagggac cccatcaccc cagctgctac tcacaggtga      900

acgaatgcct gagcaatccc tgcatccatg gaaactgtac tggaggtctc agtggatata      960

agtgtctctg tgatgcaggc tgggttggca tcaactgtga agtggacaaa aatgaatgcc     1020

tttcgaatcc atgccagaat ggaggaactt gtgacaatct ggtgaatgga tacaggtgta     1080

cttgcaagaa gggctttaaa ggctataact gccaggtgaa tattgatgaa tgtgcctcaa     1140

atccatgcct gaaccaagga acctgctttg atgacataag tggctacact tgccactgtg     1200

tgctgccata cacaggcaag aattgtcaga cagtattggc tccctgttcc ccaaaccctt     1260

gtgagaatgc tgctgtttgc aaagagtcac caaattttga gagttatact tgcttgtgtg     1320

ctcctggctg gcaaggtcag cggtgtacca ttgacattga cgagtgtatc tccaagccct     1380

gcatgaacca tggtctctgc cataacaccc agggcagcta catgtgtgaa tgtccaccag     1440

gcttcagtgg tatggactgt gaggaggaca ttgatgactg ccttgccaat ccttgccaga     1500

atggaggttc ctgtatggat ggagtgaata ctttctcctg cctctgcctt ccgggtttca     1560

ctggggataa gtgccagaca gacatgaatg agtgtctgag tgaaccctgt aagaatggag     1620

ggacctgctc tgactacgtc aacagttaca cttgcaagtg ccaggcagga tttgatggag     1680

tccattgtga gaacaacatc aatgagtgca ctgagagctc ctgtttcaat ggtggcacat     1740

gtgttgatgg gattaactcc ttctcttgct tgtgccctgt gggtttcact ggatccttct     1800

gcctccatga gatcaatgaa tgcagctctc atccatgcct gaatgaggga acgtgtgttg     1860

atggcctggg tacctaccgc tgcagctgcc ccctgggcta cactgggaaa aactgtcaga     1920

ccctggtgaa tctctgcagt cggtctccat gtaaaaacaa aggtacttgc gttcagaaaa     1980

aagcagagtc ccagtgccta tgtccatctg gatgggctgg tgcctattgt gacgtgccca     2040

atgtctcttg tgacatagca gcctccagga gaggtgtgct tgttgaacac ttgtgccagc     2100

actcaggtgt ctgcatcaat gctggcaaca cgcattactg tcagtgcccc ctgggctata     2160

ctgggagcta ctgtgaggag caactcgatg agtgtgcgtc caacccctgc cagcacgggg     2220

caacatgcag tgacttcatt ggtggataca gatgcgagtg tgtcccaggc tatcagggtg     2280

tcaactgtga gtatgaagtg gatgagtgcc agaatcagcc ctgccagaat ggaggcacct     2340

gtattgacct tgtgaaccat ttcaagtgct cttgcccacc aggcactcgg ggcctactct     2400

gtgaagagaa cattgatgac tgtgcccggg gtccccattg ccttaatggt ggtcagtgca     2460

tggataggat tggaggctac agttgtcgct gcttgcctgg ctttgctggg gagcgttgtg     2520

agggagacat caacgagtgc ctctccaacc cctgcagctc tgagggcagc ctggactgta     2580

tacagctcac caatgactac ctgtgtgttt gccgtagtgc ctttactggc cggcactgtg     2640

aaaccttcgt cgatgtgtgt ccccagatgc cctgcctgaa tggagggact tgtgctgtgg     2700

ccagtaacat gcctgatggt ttcatttgcc gttgtccccc gggattttcc ggggcaaggt     2760

gccagagcag ctgtggacaa gtgaaatgta ggaaggggga gcagtgtgtg cacaccgcct     2820

ctggaccccg ctgcttctgc cccagtcccc gggactgcga gtcaggctgt gccagtagcc     2880

cctgccagca cgggggcagc tgccaccctc agcgccagcc tccttattac tcctgccagt     2940

gtgccccacc attctcgggt agccgctgtg aactctacac ggcacccccc agcacccctc     3000

ctgccacctg tctgagccag tattgtgccg acaaagctcg ggatggcgtc tgtgatgagg     3060

cctgcaacag ccatgcctgc cagtgggatg ggggtgactg ttctctcacc atggagaacc     3120

cctgggccaa ctgctcctcc ccacttccct gctgggatta tatcaacaac cagtgtgatg     3180

agctgtgcaa cacggtcgag tgcctgtttg acaactttga atgccagggg aacagcaaga     3240

catgcaagta tgacaaatac tgtgcagacc acttcaaaga caaccactgt gaccaggggt     3300

gcaacagtga ggagtgtggt tgggatgggc tggactgtgc tgctgaccaa cctgagaacc     3360

tggcagaagg taccctggtt attgtggtat tgatgccacc tgaacaactg ctccaggatg     3420

ctcgcagctt cttgcgggca ctgggtaccc tgctccacac caacctgcgc attaagcggg     3480

actcccaggg ggaactcatg gtgtacccct attatggtga gaagtcagct gctatgaaga     3540

aacagaggat gacacgcaga tcccttcctg gtgaacaaga acaggaggtg gctggctcta     3600

aagtctttct ggaaattgac aaccgccagt gtgttcaaga ctcagaccac tgcttcaaga     3660

acacggatgc agcagcagct ctcctggcct ctcacgccat acaggggacc ctgtcatacc     3720

ctcttgtgtc tgtcgtcagt gaatccctga ctccagaacg cactcagctc ctctatctcc     3780

ttgctgttgc tgttgtcatc attctgttta ttattctgct gggggtaatc atggcaaaac     3840

gaaagcgtaa gcatggctct ctctggctgc ctgaaggttt cactcttcgc cgagatgcaa     3900

gcaatcacaa gcgtcgtgag ccagtgggac aggatgctgt ggggctgaaa aatctctcag     3960

tgcaagtctc agaagctaac ctaattggta ctggaacaag tgaacactgg gtcgatgatg     4020

aagggcccca gccaaagaaa gtaaaggctg aagatgaggc cttactctca gaagaagatg     4080

accccattga tcgacggcca tggacacagc agcaccttga agctgcagac atccgtagga     4140

caccatcgct ggctctcacc cctcctcagg cagagcagga ggtggatgtg ttagatgtga     4200

atgtccgtgg cccagatggc tgcaccccat tgatgttggc ttctctccga ggaggcagct     4260

cagatttgag tgatgaagat gaagatgcag aggactcttc tgctaacatc atcacagact     4320

tggtctacca gggtgccagc ctccaggccc agacagaccg gactggtgag atggccctgc     4380

accttgcagc ccgctactca cgggctgatg ctgccaagcg tctcctggat gcaggtgcag     4440

atgccaatgc ccaggacaac atgggccgct gtccactcca tgctgcagtg gcagctgatg     4500

cccaaggtgt cttccagatt ctgattcgca accgagtaac tgatctagat gccaggatga     4560

atgatggtac tacacccctg atcctggctg cccgcctggc tgtggaggga atggtggcag     4620

aactgatcaa ctgccaagcg gatgtgaatg cagtggatga ccatggaaaa tctgctcttc     4680

actgggcagc tgctgtcaat aatgtggagg caactctttt gttgttgaaa aatggggcca     4740

accgagacat gcaggacaac aaggaagaga cacctctgtt tcttgctgcc cgggagggga     4800

gctatgaagc agccaagatc ctgttagacc attttgccaa tcgagacatc acagaccata     4860

tggatcgtct tccccgggat gtggctcggg atcgcatgca ccatgacatt gtgcgccttc     4920

tggatgaata caatgtgacc ccaagccctc caggcaccgt gttgacttct gctctctcac     4980

ctgtcatctg tgggcccaac agatctttcc tcagcctgaa gcacacccca atgggcaaga     5040

agtctagacg gcccagtgcc aagagtacca tgcctactag cctccctaac cttgccaagg     5100

aggcaaagga tgccaagggt agtaggagga agaagtctct gagtgagaag gtccaactgt     5160

ctgagagttc agtaacttta tcccctgttg attccctaga atctcctcac acgtatgttt     5220

ccgacaccac atcctctcca atgattacat cccctgggat cttacaggcc tcacccaacc     5280

ctatgttggc cactgccgcc cctcctgccc cagtccatgc ccagcatgca ctatcttttt     5340

ctaaccttca tgaaatgcag cctttggcac atggggccag cactgtgctt ccctcagtga     5400

gccagttgct atcccaccac cacattgtgt ctccaggcag tggcagtgct ggaagcttga     5460

gtaggctcca tccagtccca gtcccagcag attggatgaa ccgcatggag gtgaatgaga     5520

cccagtacaa tgagatgttt ggtatggtcc tggctccagc tgagggcacc catcctggca     5580

tagctcccca gagcaggcca cctgaaggga agcacataac cacccctcgg gagcccttgc     5640

cccccattgt gactttccag ctcatcccta aaggcagtat tgcccaacca gcgggggctc     5700

cccagcctca gtccacctgc cctccagctg ttgcgggccc cctgcccacc atgtaccaga     5760

ttccagaaat ggcccgtttg cccagtgtgg ctttccccac tgccatgatg ccccagcagg     5820

acgggcaggt agctcagacc attctcccag cctatcatcc tttcccagcc tctgtgggca     5880

agtaccccac acccccttca cagcacagtt atgcttcctc aaatgctgct gagcgaacac     5940

ccagtcacag tggtcacctc cagggtgagc atccctacct gacaccatcc ccagagtctc     6000

ctgaccagtg gtcaagttca tcaccccact ctgcttctga ctggtcagat gtgaccacca     6060

gccctacccc tgggggtgct ggaggaggtc agcggggacc tgggacacac atgtctgagc     6120

caccacacaa caacatgcag gtttatgcgt gagagagtcc acctccagtg tagagacata     6180

actgactttt gtaaatgctg ctgaggaaca aatgaaggtc atccgggaga gaaatgaaga     6240

aatctctgga gccagcttct agaggtagga aagagaagat gttcttattc agataatgca     6300

agagaagcaa ttcgtcagtt tcactgggta tctgcaaggc ttattgatta ttctaatcta     6360

ataagacaag tttgtggaaa tgcaagatga atacaagcct tgggtccatg tttactctct     6420

tctatttgga gaataagatg gatgcttatt gaagcccaga cattcttgca gcttggactg     6480

cattttaagc cctgcaggct tctgccatat ccatgagaag attctacact agcgtcctgt     6540

tgggaattat gccctggaat tctgcctgaa ttgacctacg catctcctcc tccttggaca     6600

ttcttttgtc ttcatttggt gcttttggtt ttgcacctct ccgtgattgt agccctacca     6660

gcatgttata gggcaagacc tttgtgcttt tgatcattct ggcccatgaa agcaactttg     6720

gtctcctttc ccctcctgtc ttcccggtat cccttggagt ctcacaaggt ttactttggt     6780

atggttctca gcacaaacct ttcaagtatg ttgtttcttt ggaaaatgga catactgtat     6840

tgtgttctcc tgcatatatc attcctggag agagaagggg agaagaatac ttttcttcaa     6900

caaattttgg gggcaggaga tcccttcaag aggctgcacc ttaatttttc ttgtctgtgt     6960

gcaggtcttc atataaactt taccaggaag aagggtgtga gtttgttgtt tttctgtgta     7020

tgggcctggt cagtgtaaag ttttatcctt gatagtctag ttactatgac cctccccact     7080

tttttaaaac cagaaaaagg tttggaatgt tggaatgacc aagagacaag ttaactcgtg     7140

caagagccag ttacccaccc acaggtcccc ctacttcctg ccaagcattc cattgactgc     7200

ctgtatggaa cacatttgtc ccagatctga gcattctagg cctgtttcac tcactcaccc     7260

agcatatgaa actagtctta actgttgagc ctttcctttc atatccacag aagacactgt     7320

ctcaaatgtt gtacccttgc catttaggac tgaactttcc ttagcccaag ggacccagtg     7380

acagttgtct tccgtttgtc agatgatcag tctctactga ttatcttgct gcttaaaggc     7440

ctgctcacca atctttcttt cacaccgtgt ggtccgtgtt actggtatac ccagtatgtt     7500

ctcactgaag acatggactt tatatgttca agtgcaggaa ttggaaagtt ggacttgttt     7560

tctatgatcc aaaacagccc tataagaagg ttggaaaagg aggaactata tagcagcctt     7620

tgctattttc tgctaccatt tcttttcctc tgaagcggcc atgacattcc ctttggcaac     7680

taacgtagaa actcaacaga acattttcct ttcctagagt caccttttag atgataatgg     7740

acaactatag acttgctcat tgttcagact gattgcccct cacctgaatc cactctctgt     7800

attcatgctc ttggcaattt ctttgacttt cttttaaggg cagaagcatt ttagttaatt     7860

gtagataaag aatagttttc ttcctcttct ccttgggcca gttaataatt ggtccatggc     7920

tacactgcaa cttccgtcca gtgctgtgat gcccatgaca cctgcaaaat aagttctgcc     7980

tgggcatttt gtagatatta acaggtgaat tcccgactct tttggtttga atgacagttc     8040

tcattccttc tatggctgca agtatgcatc agtgcttccc acttacctga tttgtctgtc     8100

ggtggcccca tatggaaacc ctgcgtgtct gttggcataa tagtttacaa atggtttttt     8160

cagtcctatc caaatttatt gaaccaacaa aaataattac ttctgccctg agataagcag     8220

attaagtttg ttcattctct gctttattct ctccatgtgg caacattctg tcagcctctt     8280

tcatagtgtg caaacatttt atcattctaa atggtgactc tctgcccttg gacccattta     8340

ttattcacag atggggagaa cctatctgca tggacctctg tggaccacag cgtacctgcc     8400

cctttctgcc ctcctgctcc agccccactt ctgaaagtat cagctactga tccagccact     8460

ggatatttta tatcctccct tttccttaag cacaatgtca gaccaaattg cttgtttctt     8520

tttcttggac tactttaatt tggatccttt gggtttggag aaagggaatg tgaaagctgt     8580

cattacagac aacaggtttc agtgatgagg aggacaacac tgcctttcaa actttttact     8640

gatctcttag attttaagaa ctcttgaatt gtgtggtatc taataaaagg gaaggtaaga     8700

tggataatca ctttctcatt tgggttctga attggagact cagtttttat gagacacatc     8760

ttttatgcca tgtatagatc ctcccctgct atttttggtt tatttttatt gttataaatg     8820

ctttctttct ttgactcctc ttctgcctgc ctttggggat aggttttttt gtttgtttat     8880

ttgcttcctc tgttttgttt taagcatcat tttcttatgt gaggtgggga agggaaaggt     8940

atgagggaaa gagagtctga gaattaaaat attttagtat aagcaattgg ctgtgatgct     9000

caaatccatt gcatcctctt attgaatttg ccaatttgta atttttgcat aataaagaac     9060

caaaggtgta atgttttgtt gagaggtggt ttagggattt tggccctaac caatacattg     9120

aatgtatgat gactatttgg gaggacacat ttatgtaccc agaggccccc actaataagt     9180

ggtactatgg ttacttcctt gtgtacattt ctcttaaaag tgatattata tctgtttgta     9240

tgagaaaccc agtaaccaat aaaatgaccg catattcctg actaaacgta gtaaggaaaa     9300

tgcacacttt gtttttactt ttccgtttca ttctaaaggt agttaagatg aaatttatat     9360

gaaagcattt ttatcacaaa ataaaaaagg tttgccaagc tcagtggtgt tgtatttttt     9420

attttccaat actgcatcca tggcctggca gtgttacctc atgatgtcat aatttgctga     9480

gagagcaaat tttcttttct ttctgaatcc cacaaagcct agcaccaaac ttcttttttt     9540

cttcctttaa ttagatcata aataaatgat cctggggaaa aagcatctgt caaataggaa     9600

acatcacaaa actgagcact cttctgtgca ctagccatag ctggtgacaa acagatggtt     9660

gctcagggac aaggtgcctt ccaatggaaa tgcgaagtag ttgctatagc aagaattggg     9720

aactgggata taagtcataa tattaattat gctgttatgt aaatgattgg tttgtaacat     9780

tccttaagtg aaatttgtgt agaacttaat atacaggatt ataaaataat attttgtgta     9840

taaatttgtt ataagttcac attcatacat ttatttataa agtcagtgag atatttgaac     9900

atgaa                                                                 9905


<210>  703
<211>  11425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of NOTCH2

<400>  703
aggctgcttc gttgcacacc cgagaaagtt tcagccaaac ttcgggcggc ggctgaggcg       60

gcggccgagg agcggcggac tcggggcgcg gggagtcgag gcatttgcgc ctgggcttcg      120

gagcgtagcg ccagggcctg agcctttgaa gcaggaggag gggaggagag agtggggctc      180

ctctatcggg accccctccc catgtggatc tgcccaggcg gcggcggcgg cggcggagga      240

ggaggcgacc gagaagatgc ccgccctgcg ccccgctctg ctgtgggcgc tgctggcgct      300

ctggctgtgc tgcgcggccc ccgcgcatgc attgcagtgt cgagatggct atgaaccctg      360

tgtaaatgaa ggaatgtgtg ttacctacca caatggcaca ggatactgca aatgtccaga      420

aggcttcttg ggggaatatt gtcaacatcg agacccctgt gagaagaacc gctgccagaa      480

tggtgggact tgtgtggccc aggccatgct ggggaaagcc acgtgccgat gtgcctcagg      540

gtttacagga gaggactgcc agtactcaac atctcatcca tgctttgtgt ctcgaccctg      600

cctgaatggc ggcacatgcc atatgctcag ccgggatacc tatgagtgca cctgtcaagt      660

cgggtttaca ggtaaggagt gccaatggac ggatgcctgc ctgtctcatc cctgtgcaaa      720

tggaagtacc tgtaccactg tggccaacca gttctcctgc aaatgcctca caggcttcac      780

agggcagaaa tgtgagactg atgtcaatga gtgtgacatt ccaggacact gccagcatgg      840

tggcacctgc ctcaacctgc ctggttccta ccagtgccag tgccctcagg gcttcacagg      900

ccagtactgt gacagcctgt atgtgccctg tgcaccctca ccttgtgtca atggaggcac      960

ctgtcggcag actggtgact tcacttttga gtgcaactgc cttccaggtt ttgaagggag     1020

cacctgtgag aggaatattg atgactgccc taaccacagg tgtcagaatg gaggggtttg     1080

tgtggatggg gtcaacactt acaactgccg ctgtccccca caatggacag gacagttctg     1140

cacagaggat gtggatgaat gcctgctgca gcccaatgcc tgtcaaaatg ggggcacctg     1200

tgccaaccgc aatggaggct atggctgtgt atgtgtcaac ggctggagtg gagatgactg     1260

cagtgagaac attgatgatt gtgccttcgc ctcctgtact ccaggctcca cctgcatcga     1320

ccgtgtggcc tccttctctt gcatgtgccc agaggggaag gcaggtctcc tgtgtcatct     1380

ggatgatgca tgcatcagca atccttgcca caagggggca ctgtgtgaca ccaaccccct     1440

aaatgggcaa tatatttgca cctgcccaca aggctacaaa ggggctgact gcacagaaga     1500

tgtggatgaa tgtgccatgg ccaatagcaa tccttgtgag catgcaggaa aatgtgtgaa     1560

cacggatggc gccttccact gtgagtgtct gaagggttat gcaggacctc gttgtgagat     1620

ggacatcaat gagtgccatt cagacccctg ccagaatgat gctacctgtc tggataagat     1680

tggaggcttc acatgtctgt gcatgccagg tttcaaaggt gtgcattgtg aattagaaat     1740

aaatgaatgt cagagcaacc cttgtgtgaa caatgggcag tgtgtggata aagtcaatcg     1800

tttccagtgc ctgtgtcctc ctggtttcac tgggccagtt tgccagattg atattgatga     1860

ctgttccagt actccgtgtc tgaatggggc aaagtgtatc gatcacccga atggctatga     1920

atgccagtgt gccacaggtt tcactggtgt gttgtgtgag gagaacattg acaactgtga     1980

ccccgatcct tgccaccatg gtcagtgtca ggatggtatt gattcctaca cctgcatctg     2040

caatcccggg tacatgggcg ccatctgcag tgaccagatt gatgaatgtt acagcagccc     2100

ttgcctgaac gatggtcgct gcattgacct ggtcaatggc taccagtgca actgccagcc     2160

aggcacgtca ggggttaatt gtgaaattaa ttttgatgac tgtgcaagta acccttgtat     2220

ccatggaatc tgtatggatg gcattaatcg ctacagttgt gtctgctcac caggattcac     2280

agggcagaga tgtaacattg acattgatga gtgtgcctcc aatccctgtc gcaagggtgc     2340

aacatgtatc aacggtgtga atggtttccg ctgtatatgc cccgagggac cccatcaccc     2400

cagctgctac tcacaggtga acgaatgcct gagcaatccc tgcatccatg gaaactgtac     2460

tggaggtctc agtggatata agtgtctctg tgatgcaggc tgggttggca tcaactgtga     2520

agtggacaaa aatgaatgcc tttcgaatcc atgccagaat ggaggaactt gtgacaatct     2580

ggtgaatgga tacaggtgta cttgcaagaa gggctttaaa ggctataact gccaggtgaa     2640

tattgatgaa tgtgcctcaa atccatgcct gaaccaagga acctgctttg atgacataag     2700

tggctacact tgccactgtg tgctgccata cacaggcaag aattgtcaga cagtattggc     2760

tccctgttcc ccaaaccctt gtgagaatgc tgctgtttgc aaagagtcac caaattttga     2820

gagttatact tgcttgtgtg ctcctggctg gcaaggtcag cggtgtacca ttgacattga     2880

cgagtgtatc tccaagccct gcatgaacca tggtctctgc cataacaccc agggcagcta     2940

catgtgtgaa tgtccaccag gcttcagtgg tatggactgt gaggaggaca ttgatgactg     3000

ccttgccaat ccttgccaga atggaggttc ctgtatggat ggagtgaata ctttctcctg     3060

cctctgcctt ccgggtttca ctggggataa gtgccagaca gacatgaatg agtgtctgag     3120

tgaaccctgt aagaatggag ggacctgctc tgactacgtc aacagttaca cttgcaagtg     3180

ccaggcagga tttgatggag tccattgtga gaacaacatc aatgagtgca ctgagagctc     3240

ctgtttcaat ggtggcacat gtgttgatgg gattaactcc ttctcttgct tgtgccctgt     3300

gggtttcact ggatccttct gcctccatga gatcaatgaa tgcagctctc atccatgcct     3360

gaatgaggga acgtgtgttg atggcctggg tacctaccgc tgcagctgcc ccctgggcta     3420

cactgggaaa aactgtcaga ccctggtgaa tctctgcagt cggtctccat gtaaaaacaa     3480

aggtacttgc gttcagaaaa aagcagagtc ccagtgccta tgtccatctg gatgggctgg     3540

tgcctattgt gacgtgccca atgtctcttg tgacatagca gcctccagga gaggtgtgct     3600

tgttgaacac ttgtgccagc actcaggtgt ctgcatcaat gctggcaaca cgcattactg     3660

tcagtgcccc ctgggctata ctgggagcta ctgtgaggag caactcgatg agtgtgcgtc     3720

caacccctgc cagcacgggg caacatgcag tgacttcatt ggtggataca gatgcgagtg     3780

tgtcccaggc tatcagggtg tcaactgtga gtatgaagtg gatgagtgcc agaatcagcc     3840

ctgccagaat ggaggcacct gtattgacct tgtgaaccat ttcaagtgct cttgcccacc     3900

aggcactcgg ggcctactct gtgaagagaa cattgatgac tgtgcccggg gtccccattg     3960

ccttaatggt ggtcagtgca tggataggat tggaggctac agttgtcgct gcttgcctgg     4020

ctttgctggg gagcgttgtg agggagacat caacgagtgc ctctccaacc cctgcagctc     4080

tgagggcagc ctggactgta tacagctcac caatgactac ctgtgtgttt gccgtagtgc     4140

ctttactggc cggcactgtg aaaccttcgt cgatgtgtgt ccccagatgc cctgcctgaa     4200

tggagggact tgtgctgtgg ccagtaacat gcctgatggt ttcatttgcc gttgtccccc     4260

gggattttcc ggggcaaggt gccagagcag ctgtggacaa gtgaaatgta ggaaggggga     4320

gcagtgtgtg cacaccgcct ctggaccccg ctgcttctgc cccagtcccc gggactgcga     4380

gtcaggctgt gccagtagcc cctgccagca cgggggcagc tgccaccctc agcgccagcc     4440

tccttattac tcctgccagt gtgccccacc attctcgggt agccgctgtg aactctacac     4500

ggcacccccc agcacccctc ctgccacctg tctgagccag tattgtgccg acaaagctcg     4560

ggatggcgtc tgtgatgagg cctgcaacag ccatgcctgc cagtgggatg ggggtgactg     4620

ttctctcacc atggagaacc cctgggccaa ctgctcctcc ccacttccct gctgggatta     4680

tatcaacaac cagtgtgatg agctgtgcaa cacggtcgag tgcctgtttg acaactttga     4740

atgccagggg aacagcaaga catgcaagta tgacaaatac tgtgcagacc acttcaaaga     4800

caaccactgt gaccaggggt gcaacagtga ggagtgtggt tgggatgggc tggactgtgc     4860

tgctgaccaa cctgagaacc tggcagaagg taccctggtt attgtggtat tgatgccacc     4920

tgaacaactg ctccaggatg ctcgcagctt cttgcgggca ctgggtaccc tgctccacac     4980

caacctgcgc attaagcggg actcccaggg ggaactcatg gtgtacccct attatggtga     5040

gaagtcagct gctatgaaga aacagaggat gacacgcaga tcccttcctg gtgaacaaga     5100

acaggaggtg gctggctcta aagtctttct ggaaattgac aaccgccagt gtgttcaaga     5160

ctcagaccac tgcttcaaga acacggatgc agcagcagct ctcctggcct ctcacgccat     5220

acaggggacc ctgtcatacc ctcttgtgtc tgtcgtcagt gaatccctga ctccagaacg     5280

cactcagctc ctctatctcc ttgctgttgc tgttgtcatc attctgttta ttattctgct     5340

gggggtaatc atggcaaaac gaaagcgtaa gcatggctct ctctggctgc ctgaaggttt     5400

cactcttcgc cgagatgcaa gcaatcacaa gcgtcgtgag ccagtgggac aggatgctgt     5460

ggggctgaaa aatctctcag tgcaagtctc agaagctaac ctaattggta ctggaacaag     5520

tgaacactgg gtcgatgatg aagggcccca gccaaagaaa gtaaaggctg aagatgaggc     5580

cttactctca gaagaagatg accccattga tcgacggcca tggacacagc agcaccttga     5640

agctgcagac atccgtagga caccatcgct ggctctcacc cctcctcagg cagagcagga     5700

ggtggatgtg ttagatgtga atgtccgtgg cccagatggc tgcaccccat tgatgttggc     5760

ttctctccga ggaggcagct cagatttgag tgatgaagat gaagatgcag aggactcttc     5820

tgctaacatc atcacagact tggtctacca gggtgccagc ctccaggccc agacagaccg     5880

gactggtgag atggccctgc accttgcagc ccgctactca cgggctgatg ctgccaagcg     5940

tctcctggat gcaggtgcag atgccaatgc ccaggacaac atgggccgct gtccactcca     6000

tgctgcagtg gcagctgatg cccaaggtgt cttccagatt ctgattcgca accgagtaac     6060

tgatctagat gccaggatga atgatggtac tacacccctg atcctggctg cccgcctggc     6120

tgtggaggga atggtggcag aactgatcaa ctgccaagcg gatgtgaatg cagtggatga     6180

ccatggaaaa tctgctcttc actgggcagc tgctgtcaat aatgtggagg caactctttt     6240

gttgttgaaa aatggggcca accgagacat gcaggacaac aaggaagaga cacctctgtt     6300

tcttgctgcc cgggagggga gctatgaagc agccaagatc ctgttagacc attttgccaa     6360

tcgagacatc acagaccata tggatcgtct tccccgggat gtggctcggg atcgcatgca     6420

ccatgacatt gtgcgccttc tggatgaata caatgtgacc ccaagccctc caggcaccgt     6480

gttgacttct gctctctcac ctgtcatctg tgggcccaac agatctttcc tcagcctgaa     6540

gcacacccca atgggcaaga agtctagacg gcccagtgcc aagagtacca tgcctactag     6600

cctccctaac cttgccaagg aggcaaagga tgccaagggt agtaggagga agaagtctct     6660

gagtgagaag gtccaactgt ctgagagttc agtaacttta tcccctgttg attccctaga     6720

atctcctcac acgtatgttt ccgacaccac atcctctcca atgattacat cccctgggat     6780

cttacaggcc tcacccaacc ctatgttggc cactgccgcc cctcctgccc cagtccatgc     6840

ccagcatgca ctatcttttt ctaaccttca tgaaatgcag cctttggcac atggggccag     6900

cactgtgctt ccctcagtga gccagttgct atcccaccac cacattgtgt ctccaggcag     6960

tggcagtgct ggaagcttga gtaggctcca tccagtccca gtcccagcag attggatgaa     7020

ccgcatggag gtgaatgaga cccagtacaa tgagatgttt ggtatggtcc tggctccagc     7080

tgagggcacc catcctggca tagctcccca gagcaggcca cctgaaggga agcacataac     7140

cacccctcgg gagcccttgc cccccattgt gactttccag ctcatcccta aaggcagtat     7200

tgcccaacca gcgggggctc cccagcctca gtccacctgc cctccagctg ttgcgggccc     7260

cctgcccacc atgtaccaga ttccagaaat ggcccgtttg cccagtgtgg ctttccccac     7320

tgccatgatg ccccagcagg acgggcaggt agctcagacc attctcccag cctatcatcc     7380

tttcccagcc tctgtgggca agtaccccac acccccttca cagcacagtt atgcttcctc     7440

aaatgctgct gagcgaacac ccagtcacag tggtcacctc cagggtgagc atccctacct     7500

gacaccatcc ccagagtctc ctgaccagtg gtcaagttca tcaccccact ctgcttctga     7560

ctggtcagat gtgaccacca gccctacccc tgggggtgct ggaggaggtc agcggggacc     7620

tgggacacac atgtctgagc caccacacaa caacatgcag gtttatgcgt gagagagtcc     7680

acctccagtg tagagacata actgactttt gtaaatgctg ctgaggaaca aatgaaggtc     7740

atccgggaga gaaatgaaga aatctctgga gccagcttct agaggtagga aagagaagat     7800

gttcttattc agataatgca agagaagcaa ttcgtcagtt tcactgggta tctgcaaggc     7860

ttattgatta ttctaatcta ataagacaag tttgtggaaa tgcaagatga atacaagcct     7920

tgggtccatg tttactctct tctatttgga gaataagatg gatgcttatt gaagcccaga     7980

cattcttgca gcttggactg cattttaagc cctgcaggct tctgccatat ccatgagaag     8040

attctacact agcgtcctgt tgggaattat gccctggaat tctgcctgaa ttgacctacg     8100

catctcctcc tccttggaca ttcttttgtc ttcatttggt gcttttggtt ttgcacctct     8160

ccgtgattgt agccctacca gcatgttata gggcaagacc tttgtgcttt tgatcattct     8220

ggcccatgaa agcaactttg gtctcctttc ccctcctgtc ttcccggtat cccttggagt     8280

ctcacaaggt ttactttggt atggttctca gcacaaacct ttcaagtatg ttgtttcttt     8340

ggaaaatgga catactgtat tgtgttctcc tgcatatatc attcctggag agagaagggg     8400

agaagaatac ttttcttcaa caaattttgg gggcaggaga tcccttcaag aggctgcacc     8460

ttaatttttc ttgtctgtgt gcaggtcttc atataaactt taccaggaag aagggtgtga     8520

gtttgttgtt tttctgtgta tgggcctggt cagtgtaaag ttttatcctt gatagtctag     8580

ttactatgac cctccccact tttttaaaac cagaaaaagg tttggaatgt tggaatgacc     8640

aagagacaag ttaactcgtg caagagccag ttacccaccc acaggtcccc ctacttcctg     8700

ccaagcattc cattgactgc ctgtatggaa cacatttgtc ccagatctga gcattctagg     8760

cctgtttcac tcactcaccc agcatatgaa actagtctta actgttgagc ctttcctttc     8820

atatccacag aagacactgt ctcaaatgtt gtacccttgc catttaggac tgaactttcc     8880

ttagcccaag ggacccagtg acagttgtct tccgtttgtc agatgatcag tctctactga     8940

ttatcttgct gcttaaaggc ctgctcacca atctttcttt cacaccgtgt ggtccgtgtt     9000

actggtatac ccagtatgtt ctcactgaag acatggactt tatatgttca agtgcaggaa     9060

ttggaaagtt ggacttgttt tctatgatcc aaaacagccc tataagaagg ttggaaaagg     9120

aggaactata tagcagcctt tgctattttc tgctaccatt tcttttcctc tgaagcggcc     9180

atgacattcc ctttggcaac taacgtagaa actcaacaga acattttcct ttcctagagt     9240

caccttttag atgataatgg acaactatag acttgctcat tgttcagact gattgcccct     9300

cacctgaatc cactctctgt attcatgctc ttggcaattt ctttgacttt cttttaaggg     9360

cagaagcatt ttagttaatt gtagataaag aatagttttc ttcctcttct ccttgggcca     9420

gttaataatt ggtccatggc tacactgcaa cttccgtcca gtgctgtgat gcccatgaca     9480

cctgcaaaat aagttctgcc tgggcatttt gtagatatta acaggtgaat tcccgactct     9540

tttggtttga atgacagttc tcattccttc tatggctgca agtatgcatc agtgcttccc     9600

acttacctga tttgtctgtc ggtggcccca tatggaaacc ctgcgtgtct gttggcataa     9660

tagtttacaa atggtttttt cagtcctatc caaatttatt gaaccaacaa aaataattac     9720

ttctgccctg agataagcag attaagtttg ttcattctct gctttattct ctccatgtgg     9780

caacattctg tcagcctctt tcatagtgtg caaacatttt atcattctaa atggtgactc     9840

tctgcccttg gacccattta ttattcacag atggggagaa cctatctgca tggacctctg     9900

tggaccacag cgtacctgcc cctttctgcc ctcctgctcc agccccactt ctgaaagtat     9960

cagctactga tccagccact ggatatttta tatcctccct tttccttaag cacaatgtca    10020

gaccaaattg cttgtttctt tttcttggac tactttaatt tggatccttt gggtttggag    10080

aaagggaatg tgaaagctgt cattacagac aacaggtttc agtgatgagg aggacaacac    10140

tgcctttcaa actttttact gatctcttag attttaagaa ctcttgaatt gtgtggtatc    10200

taataaaagg gaaggtaaga tggataatca ctttctcatt tgggttctga attggagact    10260

cagtttttat gagacacatc ttttatgcca tgtatagatc ctcccctgct atttttggtt    10320

tatttttatt gttataaatg ctttctttct ttgactcctc ttctgcctgc ctttggggat    10380

aggttttttt gtttgtttat ttgcttcctc tgttttgttt taagcatcat tttcttatgt    10440

gaggtgggga agggaaaggt atgagggaaa gagagtctga gaattaaaat attttagtat    10500

aagcaattgg ctgtgatgct caaatccatt gcatcctctt attgaatttg ccaatttgta    10560

atttttgcat aataaagaac caaaggtgta atgttttgtt gagaggtggt ttagggattt    10620

tggccctaac caatacattg aatgtatgat gactatttgg gaggacacat ttatgtaccc    10680

agaggccccc actaataagt ggtactatgg ttacttcctt gtgtacattt ctcttaaaag    10740

tgatattata tctgtttgta tgagaaaccc agtaaccaat aaaatgaccg catattcctg    10800

actaaacgta gtaaggaaaa tgcacacttt gtttttactt ttccgtttca ttctaaaggt    10860

agttaagatg aaatttatat gaaagcattt ttatcacaaa ataaaaaagg tttgccaagc    10920

tcagtggtgt tgtatttttt attttccaat actgcatcca tggcctggca gtgttacctc    10980

atgatgtcat aatttgctga gagagcaaat tttcttttct ttctgaatcc cacaaagcct    11040

agcaccaaac ttcttttttt cttcctttaa ttagatcata aataaatgat cctggggaaa    11100

aagcatctgt caaataggaa acatcacaaa actgagcact cttctgtgca ctagccatag    11160

ctggtgacaa acagatggtt gctcagggac aaggtgcctt ccaatggaaa tgcgaagtag    11220

ttgctatagc aagaattggg aactgggata taagtcataa tattaattat gctgttatgt    11280

aaatgattgg tttgtaacat tccttaagtg aaatttgtgt agaacttaat atacaggatt    11340

ataaaataat attttgtgta taaatttgtt ataagttcac attcatacat ttatttataa    11400

agtcagtgag atatttgaac atgaa                                          11425


<210>  704
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  704

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His 
            20                  


<210>  705
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  705

Leu Gln Cys Arg Asp Gly Tyr Glu Pro Cys Val Asn Glu Gly Met Cys 
1               5                   10                  15      


Val Thr Tyr His Asn Gly Thr Gly Tyr Cys 
            20                  25      


<210>  706
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  706

Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His Arg Asp Pro Cys 
1               5                   10                  15      


Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val Ala Gln Ala Met 
            20                  25                  30          


Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe Thr Gly Glu Asp 
        35                  40                  45              


Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser Arg Pro Cys Leu 
    50                  55                  60                  


Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr Tyr Glu Cys Thr 
65                  70                  75                  80  


Cys Gln Val Gly Phe Thr 
                85      


<210>  707
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  707

Lys Glu Cys Gln Trp Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn 
1               5                   10                  15      


Gly Ser Thr Cys Thr Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu 
            20                  25                  30          


Thr Gly Phe Thr Gly Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp 
        35                  40                  45              


Ile Pro Gly His Cys Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly 
    50                  55                  60                  


Ser Tyr Gln Cys Gln Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp 
65                  70                  75                  80  


Ser Leu Tyr Val Pro Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr 
                85                  90                  95      


Cys Arg Gln Thr Gly Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro 
            100                 105                 110     


<210>  708
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  708

Phe Glu Gly Ser Thr Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His 
1               5                   10                  15      


Arg Cys Gln Asn Gly Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn 
            20                  25                  30          


Cys Arg Cys Pro Pro Gln Trp Thr 
        35                  40  


<210>  709
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  709

Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu Gln Pro Asn Ala 
1               5                   10                  15      


Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly Gly Tyr Gly Cys 
            20                  25                  30          


Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser Glu Asn Ile Asp 
        35                  40                  45              


Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr Cys Ile Asp Arg 
    50                  55                  60                  


Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys Ala 
65                  70                  75          


<210>  710
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  710

Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys His Lys 
1               5                   10                  15      


Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile Cys Thr 
            20                  25                  30          


Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val Asp Glu 
        35                  40                  45              


Cys Ala Met 
    50      


<210>  711
<211>  2049
<212>  PRT
<213>  Homo sapiens

<400>  711

Asn Ser Asn Pro Cys Glu His Ala Gly Lys Cys Val Asn Thr Asp Gly 
1               5                   10                  15      


Ala Phe His Cys Glu Cys Leu Lys Gly Tyr Ala Gly Pro Arg Cys Glu 
            20                  25                  30          


Met Asp Ile Asn Glu Cys His Ser Asp Pro Cys Gln Asn Asp Ala Thr 
        35                  40                  45              


Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys Leu Cys Met Pro Gly Phe 
    50                  55                  60                  


Lys Gly Val His Cys Glu Leu Glu Ile Asn Glu Cys Gln Ser Asn Pro 
65                  70                  75                  80  


Cys Val Asn Asn Gly Gln Cys Val Asp Lys Val Asn Arg Phe Gln Cys 
                85                  90                  95      


Leu Cys Pro Pro Gly Phe Thr Gly Pro Val Cys Gln Ile Asp Ile Asp 
            100                 105                 110         


Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly Ala Lys Cys Ile Asp His 
        115                 120                 125             


Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr Gly Phe Thr Gly Val Leu 
    130                 135                 140                 


Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro Asp Pro Cys His His Gly 
145                 150                 155                 160 


Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr Cys Ile Cys Asn Pro Gly 
                165                 170                 175     


Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile Asp Glu Cys Tyr Ser Ser 
            180                 185                 190         


Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp Leu Val Asn Gly Tyr Gln 
        195                 200                 205             


Cys Asn Cys Gln Pro Gly Thr Ser Gly Val Asn Cys Glu Ile Asn Phe 
    210                 215                 220                 


Asp Asp Cys Ala Ser Asn Pro Cys Ile His Gly Ile Cys Met Asp Gly 
225                 230                 235                 240 


Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro Gly Phe Thr Gly Gln Arg 
                245                 250                 255     


Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys Arg Lys Gly 
            260                 265                 270         


Ala Thr Cys Ile Asn Gly Val Asn Gly Phe Arg Cys Ile Cys Pro Glu 
        275                 280                 285             


Gly Pro His His Pro Ser Cys Tyr Ser Gln Val Asn Glu Cys Leu Ser 
    290                 295                 300                 


Asn Pro Cys Ile His Gly Asn Cys Thr Gly Gly Leu Ser Gly Tyr Lys 
305                 310                 315                 320 


Cys Leu Cys Asp Ala Gly Trp Val Gly Ile Asn Cys Glu Val Asp Lys 
                325                 330                 335     


Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Asp Asn 
            340                 345                 350         


Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys Lys Gly Phe Lys Gly Tyr 
        355                 360                 365             


Asn Cys Gln Val Asn Ile Asp Glu Cys Ala Ser Asn Pro Cys Leu Asn 
    370                 375                 380                 


Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly Tyr Thr Cys His Cys Val 
385                 390                 395                 400 


Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr Val Leu Ala Pro Cys Ser 
                405                 410                 415     


Pro Asn Pro Cys Glu Asn Ala Ala Val Cys Lys Glu Ser Pro Asn Phe 
            420                 425                 430         


Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly Trp Gln Gly Gln Arg Cys 
        435                 440                 445             


Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys Pro Cys Met Asn His Gly 
    450                 455                 460                 


Leu Cys His Asn Thr Gln Gly Ser Tyr Met Cys Glu Cys Pro Pro Gly 
465                 470                 475                 480 


Phe Ser Gly Met Asp Cys Glu Glu Asp Ile Asp Asp Cys Leu Ala Asn 
                485                 490                 495     


Pro Cys Gln Asn Gly Gly Ser Cys Met Asp Gly Val Asn Thr Phe Ser 
            500                 505                 510         


Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp Lys Cys Gln Thr Asp Met 
        515                 520                 525             


Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn Gly Gly Thr Cys Ser Asp 
    530                 535                 540                 


Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln Ala Gly Phe Asp Gly Val 
545                 550                 555                 560 


His Cys Glu Asn Asn Ile Asn Glu Cys Thr Glu Ser Ser Cys Phe Asn 
                565                 570                 575     


Gly Gly Thr Cys Val Asp Gly Ile Asn Ser Phe Ser Cys Leu Cys Pro 
            580                 585                 590         


Val Gly Phe Thr Gly Ser Phe Cys Leu His Glu Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser His Pro Cys Leu Asn Glu Gly Thr Cys Val Asp Gly Leu Gly Thr 
    610                 615                 620                 


Tyr Arg Cys Ser Cys Pro Leu Gly Tyr Thr Gly Lys Asn Cys Gln Thr 
625                 630                 635                 640 


Leu Val Asn Leu Cys Ser Arg Ser Pro Cys Lys Asn Lys Gly Thr Cys 
                645                 650                 655     


Val Gln Lys Lys Ala Glu Ser Gln Cys Leu Cys Pro Ser Gly Trp Ala 
            660                 665                 670         


Gly Ala Tyr Cys Asp Val Pro Asn Val Ser Cys Asp Ile Ala Ala Ser 
        675                 680                 685             


Arg Arg Gly Val Leu Val Glu His Leu Cys Gln His Ser Gly Val Cys 
    690                 695                 700                 


Ile Asn Ala Gly Asn Thr His Tyr Cys Gln Cys Pro Leu Gly Tyr Thr 
705                 710                 715                 720 


Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu Cys Ala Ser Asn Pro Cys 
                725                 730                 735     


Gln His Gly Ala Thr Cys Ser Asp Phe Ile Gly Gly Tyr Arg Cys Glu 
            740                 745                 750         


Cys Val Pro Gly Tyr Gln Gly Val Asn Cys Glu Tyr Glu Val Asp Glu 
        755                 760                 765             


Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly Thr Cys Ile Asp Leu Val 
    770                 775                 780                 


Asn His Phe Lys Cys Ser Cys Pro Pro Gly Thr Arg Gly Leu Leu Cys 
785                 790                 795                 800 


Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly Pro His Cys Leu Asn Gly 
                805                 810                 815     


Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr Ser Cys Arg Cys Leu Pro 
            820                 825                 830         


Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp Ile Asn Glu Cys Leu Ser 
        835                 840                 845             


Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp Cys Ile Gln Leu Thr Asn 
    850                 855                 860                 


Asp Tyr Leu Cys Val Cys Arg Ser Ala Phe Thr Gly Arg His Cys Glu 
865                 870                 875                 880 


Thr Phe Val Asp Val Cys Pro Gln Met Pro Cys Leu Asn Gly Gly Thr 
                885                 890                 895     


Cys Ala Val Ala Ser Asn Met Pro Asp Gly Phe Ile Cys Arg Cys Pro 
            900                 905                 910         


Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser Ser Cys Gly Gln Val Lys 
        915                 920                 925             


Cys Arg Lys Gly Glu Gln Cys Val His Thr Ala Ser Gly Pro Arg Cys 
    930                 935                 940                 


Phe Cys Pro Ser Pro Arg Asp Cys Glu Ser Gly Cys Ala Ser Ser Pro 
945                 950                 955                 960 


Cys Gln His Gly Gly Ser Cys His Pro Gln Arg Gln Pro Pro Tyr Tyr 
                965                 970                 975     


Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly Ser Arg Cys Glu Leu Tyr 
            980                 985                 990         


Thr Ala Pro Pro Ser Thr Pro Pro  Ala Thr Cys Leu Ser  Gln Tyr Cys 
        995                 1000                 1005             


Ala Asp  Lys Ala Arg Asp Gly  Val Cys Asp Glu Ala  Cys Asn Ser 
    1010                 1015                 1020             


His Ala  Cys Gln Trp Asp Gly  Gly Asp Cys Ser Leu  Thr Met Glu 
    1025                 1030                 1035             


Asn Pro  Trp Ala Asn Cys Ser  Ser Pro Leu Pro Cys  Trp Asp Tyr 
    1040                 1045                 1050             


Ile Asn  Asn Gln Cys Asp Glu  Leu Cys Asn Thr Val  Glu Cys Leu 
    1055                 1060                 1065             


Phe Asp  Asn Phe Glu Cys Gln  Gly Asn Ser Lys Thr  Cys Lys Tyr 
    1070                 1075                 1080             


Asp Lys  Tyr Cys Ala Asp His  Phe Lys Asp Asn His  Cys Asp Gln 
    1085                 1090                 1095             


Gly Cys  Asn Ser Glu Glu Cys  Gly Trp Asp Gly Leu  Asp Cys Ala 
    1100                 1105                 1110             


Ala Asp  Gln Pro Glu Asn Leu  Ala Glu Gly Thr Leu  Val Ile Val 
    1115                 1120                 1125             


Val Leu  Met Pro Pro Glu Gln  Leu Leu Gln Asp Ala  Arg Ser Phe 
    1130                 1135                 1140             


Leu Arg  Ala Leu Gly Thr Leu  Leu His Thr Asn Leu  Arg Ile Lys 
    1145                 1150                 1155             


Arg Asp  Ser Gln Gly Glu Leu  Met Val Tyr Pro Tyr  Tyr Gly Glu 
    1160                 1165                 1170             


Lys Ser  Ala Ala Met Lys Lys  Gln Arg Met Thr Arg  Arg Ser Leu 
    1175                 1180                 1185             


Pro Gly  Glu Gln Glu Gln Glu  Val Ala Gly Ser Lys  Val Phe Leu 
    1190                 1195                 1200             


Glu Ile  Asp Asn Arg Gln Cys  Val Gln Asp Ser Asp  His Cys Phe 
    1205                 1210                 1215             


Lys Asn  Thr Asp Ala Ala Ala  Ala Leu Leu Ala Ser  His Ala Ile 
    1220                 1225                 1230             


Gln Gly  Thr Leu Ser Tyr Pro  Leu Val Ser Val Val  Ser Glu Ser 
    1235                 1240                 1245             


Leu Thr  Pro Glu Arg Thr Gln  Leu Leu Tyr Leu Leu  Ala Val Ala 
    1250                 1255                 1260             


Val Val  Ile Ile Leu Phe Ile  Ile Leu Leu Gly Val  Ile Met Ala 
    1265                 1270                 1275             


Lys Arg  Lys Arg Lys His Gly  Ser Leu Trp Leu Pro  Glu Gly Phe 
    1280                 1285                 1290             


Thr Leu  Arg Arg Asp Ala Ser  Asn His Lys Arg Arg  Glu Pro Val 
    1295                 1300                 1305             


Gly Gln  Asp Ala Val Gly Leu  Lys Asn Leu Ser Val  Gln Val Ser 
    1310                 1315                 1320             


Glu Ala  Asn Leu Ile Gly Thr  Gly Thr Ser Glu His  Trp Val Asp 
    1325                 1330                 1335             


Asp Glu  Gly Pro Gln Pro Lys  Lys Val Lys Ala Glu  Asp Glu Ala 
    1340                 1345                 1350             


Leu Leu  Ser Glu Glu Asp Asp  Pro Ile Asp Arg Arg  Pro Trp Thr 
    1355                 1360                 1365             


Gln Gln  His Leu Glu Ala Ala  Asp Ile Arg Arg Thr  Pro Ser Leu 
    1370                 1375                 1380             


Ala Leu  Thr Pro Pro Gln Ala  Glu Gln Glu Val Asp  Val Leu Asp 
    1385                 1390                 1395             


Val Asn  Val Arg Gly Pro Asp  Gly Cys Thr Pro Leu  Met Leu Ala 
    1400                 1405                 1410             


Ser Leu  Arg Gly Gly Ser Ser  Asp Leu Ser Asp Glu  Asp Glu Asp 
    1415                 1420                 1425             


Ala Glu  Asp Ser Ser Ala Asn  Ile Ile Thr Asp Leu  Val Tyr Gln 
    1430                 1435                 1440             


Gly Ala  Ser Leu Gln Ala Gln  Thr Asp Arg Thr Gly  Glu Met Ala 
    1445                 1450                 1455             


Leu His  Leu Ala Ala Arg Tyr  Ser Arg Ala Asp Ala  Ala Lys Arg 
    1460                 1465                 1470             


Leu Leu  Asp Ala Gly Ala Asp  Ala Asn Ala Gln Asp  Asn Met Gly 
    1475                 1480                 1485             


Arg Cys  Pro Leu His Ala Ala  Val Ala Ala Asp Ala  Gln Gly Val 
    1490                 1495                 1500             


Phe Gln  Ile Leu Ile Arg Asn  Arg Val Thr Asp Leu  Asp Ala Arg 
    1505                 1510                 1515             


Met Asn  Asp Gly Thr Thr Pro  Leu Ile Leu Ala Ala  Arg Leu Ala 
    1520                 1525                 1530             


Val Glu  Gly Met Val Ala Glu  Leu Ile Asn Cys Gln  Ala Asp Val 
    1535                 1540                 1545             


Asn Ala  Val Asp Asp His Gly  Lys Ser Ala Leu His  Trp Ala Ala 
    1550                 1555                 1560             


Ala Val  Asn Asn Val Glu Ala  Thr Leu Leu Leu Leu  Lys Asn Gly 
    1565                 1570                 1575             


Ala Asn  Arg Asp Met Gln Asp  Asn Lys Glu Glu Thr  Pro Leu Phe 
    1580                 1585                 1590             


Leu Ala  Ala Arg Glu Gly Ser  Tyr Glu Ala Ala Lys  Ile Leu Leu 
    1595                 1600                 1605             


Asp His  Phe Ala Asn Arg Asp  Ile Thr Asp His Met  Asp Arg Leu 
    1610                 1615                 1620             


Pro Arg  Asp Val Ala Arg Asp  Arg Met His His Asp  Ile Val Arg 
    1625                 1630                 1635             


Leu Leu  Asp Glu Tyr Asn Val  Thr Pro Ser Pro Pro  Gly Thr Val 
    1640                 1645                 1650             


Leu Thr  Ser Ala Leu Ser Pro  Val Ile Cys Gly Pro  Asn Arg Ser 
    1655                 1660                 1665             


Phe Leu  Ser Leu Lys His Thr  Pro Met Gly Lys Lys  Ser Arg Arg 
    1670                 1675                 1680             


Pro Ser  Ala Lys Ser Thr Met  Pro Thr Ser Leu Pro  Asn Leu Ala 
    1685                 1690                 1695             


Lys Glu  Ala Lys Asp Ala Lys  Gly Ser Arg Arg Lys  Lys Ser Leu 
    1700                 1705                 1710             


Ser Glu  Lys Val Gln Leu Ser  Glu Ser Ser Val Thr  Leu Ser Pro 
    1715                 1720                 1725             


Val Asp  Ser Leu Glu Ser Pro  His Thr Tyr Val Ser  Asp Thr Thr 
    1730                 1735                 1740             


Ser Ser  Pro Met Ile Thr Ser  Pro Gly Ile Leu Gln  Ala Ser Pro 
    1745                 1750                 1755             


Asn Pro  Met Leu Ala Thr Ala  Ala Pro Pro Ala Pro  Val His Ala 
    1760                 1765                 1770             


Gln His  Ala Leu Ser Phe Ser  Asn Leu His Glu Met  Gln Pro Leu 
    1775                 1780                 1785             


Ala His  Gly Ala Ser Thr Val  Leu Pro Ser Val Ser  Gln Leu Leu 
    1790                 1795                 1800             


Ser His  His His Ile Val Ser  Pro Gly Ser Gly Ser  Ala Gly Ser 
    1805                 1810                 1815             


Leu Ser  Arg Leu His Pro Val  Pro Val Pro Ala Asp  Trp Met Asn 
    1820                 1825                 1830             


Arg Met  Glu Val Asn Glu Thr  Gln Tyr Asn Glu Met  Phe Gly Met 
    1835                 1840                 1845             


Val Leu  Ala Pro Ala Glu Gly  Thr His Pro Gly Ile  Ala Pro Gln 
    1850                 1855                 1860             


Ser Arg  Pro Pro Glu Gly Lys  His Ile Thr Thr Pro  Arg Glu Pro 
    1865                 1870                 1875             


Leu Pro  Pro Ile Val Thr Phe  Gln Leu Ile Pro Lys  Gly Ser Ile 
    1880                 1885                 1890             


Ala Gln  Pro Ala Gly Ala Pro  Gln Pro Gln Ser Thr  Cys Pro Pro 
    1895                 1900                 1905             


Ala Val  Ala Gly Pro Leu Pro  Thr Met Tyr Gln Ile  Pro Glu Met 
    1910                 1915                 1920             


Ala Arg  Leu Pro Ser Val Ala  Phe Pro Thr Ala Met  Met Pro Gln 
    1925                 1930                 1935             


Gln Asp  Gly Gln Val Ala Gln  Thr Ile Leu Pro Ala  Tyr His Pro 
    1940                 1945                 1950             


Phe Pro  Ala Ser Val Gly Lys  Tyr Pro Thr Pro Pro  Ser Gln His 
    1955                 1960                 1965             


Ser Tyr  Ala Ser Ser Asn Ala  Ala Glu Arg Thr Pro  Ser His Ser 
    1970                 1975                 1980             


Gly His  Leu Gln Gly Glu His  Pro Tyr Leu Thr Pro  Ser Pro Glu 
    1985                 1990                 1995             


Ser Pro  Asp Gln Trp Ser Ser  Ser Ser Pro His Ser  Ala Ser Asp 
    2000                 2005                 2010             


Trp Ser  Asp Val Thr Thr Ser  Pro Thr Pro Gly Gly  Ala Gly Gly 
    2015                 2020                 2025             


Gly Gln  Arg Gly Pro Gly Thr  His Met Ser Glu Pro  Pro His Asn 
    2030                 2035                 2040             


Asn Met  Gln Val Tyr Ala 
    2045                 


<210>  712
<211>  2471
<212>  PRT
<213>  Homo sapiens

<400>  712

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 


His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 


Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     


Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         


Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             


Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 


Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 


Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     


Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         


Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             


Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 


Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 


Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     


Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         


Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             


Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 


Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 


Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     


Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         


Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             


Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 


Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 


Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     


Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         


Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             


Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 


Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 


Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     


Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         


Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             


Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 


Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 


Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     


Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         


Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             


Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 


Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 


Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     


Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         


Glu Ser Ser Cys Phe Asn Gly Gly  Thr Cys Val Asp Gly  Ile Asn Ser 
        995                 1000                 1005             


Phe Ser  Cys Leu Cys Pro Val  Gly Phe Thr Gly Ser  Phe Cys Leu 
    1010                 1015                 1020             


His Glu  Ile Asn Glu Cys Ser  Ser His Pro Cys Leu  Asn Glu Gly 
    1025                 1030                 1035             


Thr Cys  Val Asp Gly Leu Gly  Thr Tyr Arg Cys Ser  Cys Pro Leu 
    1040                 1045                 1050             


Gly Tyr  Thr Gly Lys Asn Cys  Gln Thr Leu Val Asn  Leu Cys Ser 
    1055                 1060                 1065             


Arg Ser  Pro Cys Lys Asn Lys  Gly Thr Cys Val Gln  Lys Lys Ala 
    1070                 1075                 1080             


Glu Ser  Gln Cys Leu Cys Pro  Ser Gly Trp Ala Gly  Ala Tyr Cys 
    1085                 1090                 1095             


Asp Val  Pro Asn Val Ser Cys  Asp Ile Ala Ala Ser  Arg Arg Gly 
    1100                 1105                 1110             


Val Leu  Val Glu His Leu Cys  Gln His Ser Gly Val  Cys Ile Asn 
    1115                 1120                 1125             


Ala Gly  Asn Thr His Tyr Cys  Gln Cys Pro Leu Gly  Tyr Thr Gly 
    1130                 1135                 1140             


Ser Tyr  Cys Glu Glu Gln Leu  Asp Glu Cys Ala Ser  Asn Pro Cys 
    1145                 1150                 1155             


Gln His  Gly Ala Thr Cys Ser  Asp Phe Ile Gly Gly  Tyr Arg Cys 
    1160                 1165                 1170             


Glu Cys  Val Pro Gly Tyr Gln  Gly Val Asn Cys Glu  Tyr Glu Val 
    1175                 1180                 1185             


Asp Glu  Cys Gln Asn Gln Pro  Cys Gln Asn Gly Gly  Thr Cys Ile 
    1190                 1195                 1200             


Asp Leu  Val Asn His Phe Lys  Cys Ser Cys Pro Pro  Gly Thr Arg 
    1205                 1210                 1215             


Gly Leu  Leu Cys Glu Glu Asn  Ile Asp Asp Cys Ala  Arg Gly Pro 
    1220                 1225                 1230             


His Cys  Leu Asn Gly Gly Gln  Cys Met Asp Arg Ile  Gly Gly Tyr 
    1235                 1240                 1245             


Ser Cys  Arg Cys Leu Pro Gly  Phe Ala Gly Glu Arg  Cys Glu Gly 
    1250                 1255                 1260             


Asp Ile  Asn Glu Cys Leu Ser  Asn Pro Cys Ser Ser  Glu Gly Ser 
    1265                 1270                 1275             


Leu Asp  Cys Ile Gln Leu Thr  Asn Asp Tyr Leu Cys  Val Cys Arg 
    1280                 1285                 1290             


Ser Ala  Phe Thr Gly Arg His  Cys Glu Thr Phe Val  Asp Val Cys 
    1295                 1300                 1305             


Pro Gln  Met Pro Cys Leu Asn  Gly Gly Thr Cys Ala  Val Ala Ser 
    1310                 1315                 1320             


Asn Met  Pro Asp Gly Phe Ile  Cys Arg Cys Pro Pro  Gly Phe Ser 
    1325                 1330                 1335             


Gly Ala  Arg Cys Gln Ser Ser  Cys Gly Gln Val Lys  Cys Arg Lys 
    1340                 1345                 1350             


Gly Glu  Gln Cys Val His Thr  Ala Ser Gly Pro Arg  Cys Phe Cys 
    1355                 1360                 1365             


Pro Ser  Pro Arg Asp Cys Glu  Ser Gly Cys Ala Ser  Ser Pro Cys 
    1370                 1375                 1380             


Gln His  Gly Gly Ser Cys His  Pro Gln Arg Gln Pro  Pro Tyr Tyr 
    1385                 1390                 1395             


Ser Cys  Gln Cys Ala Pro Pro  Phe Ser Gly Ser Arg  Cys Glu Leu 
    1400                 1405                 1410             


Tyr Thr  Ala Pro Pro Ser Thr  Pro Pro Ala Thr Cys  Leu Ser Gln 
    1415                 1420                 1425             


Tyr Cys  Ala Asp Lys Ala Arg  Asp Gly Val Cys Asp  Glu Ala Cys 
    1430                 1435                 1440             


Asn Ser  His Ala Cys Gln Trp  Asp Gly Gly Asp Cys  Ser Leu Thr 
    1445                 1450                 1455             


Met Glu  Asn Pro Trp Ala Asn  Cys Ser Ser Pro Leu  Pro Cys Trp 
    1460                 1465                 1470             


Asp Tyr  Ile Asn Asn Gln Cys  Asp Glu Leu Cys Asn  Thr Val Glu 
    1475                 1480                 1485             


Cys Leu  Phe Asp Asn Phe Glu  Cys Gln Gly Asn Ser  Lys Thr Cys 
    1490                 1495                 1500             


Lys Tyr  Asp Lys Tyr Cys Ala  Asp His Phe Lys Asp  Asn His Cys 
    1505                 1510                 1515             


Asp Gln  Gly Cys Asn Ser Glu  Glu Cys Gly Trp Asp  Gly Leu Asp 
    1520                 1525                 1530             


Cys Ala  Ala Asp Gln Pro Glu  Asn Leu Ala Glu Gly  Thr Leu Val 
    1535                 1540                 1545             


Ile Val  Val Leu Met Pro Pro  Glu Gln Leu Leu Gln  Asp Ala Arg 
    1550                 1555                 1560             


Ser Phe  Leu Arg Ala Leu Gly  Thr Leu Leu His Thr  Asn Leu Arg 
    1565                 1570                 1575             


Ile Lys  Arg Asp Ser Gln Gly  Glu Leu Met Val Tyr  Pro Tyr Tyr 
    1580                 1585                 1590             


Gly Glu  Lys Ser Ala Ala Met  Lys Lys Gln Arg Met  Thr Arg Arg 
    1595                 1600                 1605             


Ser Leu  Pro Gly Glu Gln Glu  Gln Glu Val Ala Gly  Ser Lys Val 
    1610                 1615                 1620             


Phe Leu  Glu Ile Asp Asn Arg  Gln Cys Val Gln Asp  Ser Asp His 
    1625                 1630                 1635             


Cys Phe  Lys Asn Thr Asp Ala  Ala Ala Ala Leu Leu  Ala Ser His 
    1640                 1645                 1650             


Ala Ile  Gln Gly Thr Leu Ser  Tyr Pro Leu Val Ser  Val Val Ser 
    1655                 1660                 1665             


Glu Ser  Leu Thr Pro Glu Arg  Thr Gln Leu Leu Tyr  Leu Leu Ala 
    1670                 1675                 1680             


Val Ala  Val Val Ile Ile Leu  Phe Ile Ile Leu Leu  Gly Val Ile 
    1685                 1690                 1695             


Met Ala  Lys Arg Lys Arg Lys  His Gly Ser Leu Trp  Leu Pro Glu 
    1700                 1705                 1710             


Gly Phe  Thr Leu Arg Arg Asp  Ala Ser Asn His Lys  Arg Arg Glu 
    1715                 1720                 1725             


Pro Val  Gly Gln Asp Ala Val  Gly Leu Lys Asn Leu  Ser Val Gln 
    1730                 1735                 1740             


Val Ser  Glu Ala Asn Leu Ile  Gly Thr Gly Thr Ser  Glu His Trp 
    1745                 1750                 1755             


Val Asp  Asp Glu Gly Pro Gln  Pro Lys Lys Val Lys  Ala Glu Asp 
    1760                 1765                 1770             


Glu Ala  Leu Leu Ser Glu Glu  Asp Asp Pro Ile Asp  Arg Arg Pro 
    1775                 1780                 1785             


Trp Thr  Gln Gln His Leu Glu  Ala Ala Asp Ile Arg  Arg Thr Pro 
    1790                 1795                 1800             


Ser Leu  Ala Leu Thr Pro Pro  Gln Ala Glu Gln Glu  Val Asp Val 
    1805                 1810                 1815             


Leu Asp  Val Asn Val Arg Gly  Pro Asp Gly Cys Thr  Pro Leu Met 
    1820                 1825                 1830             


Leu Ala  Ser Leu Arg Gly Gly  Ser Ser Asp Leu Ser  Asp Glu Asp 
    1835                 1840                 1845             


Glu Asp  Ala Glu Asp Ser Ser  Ala Asn Ile Ile Thr  Asp Leu Val 
    1850                 1855                 1860             


Tyr Gln  Gly Ala Ser Leu Gln  Ala Gln Thr Asp Arg  Thr Gly Glu 
    1865                 1870                 1875             


Met Ala  Leu His Leu Ala Ala  Arg Tyr Ser Arg Ala  Asp Ala Ala 
    1880                 1885                 1890             


Lys Arg  Leu Leu Asp Ala Gly  Ala Asp Ala Asn Ala  Gln Asp Asn 
    1895                 1900                 1905             


Met Gly  Arg Cys Pro Leu His  Ala Ala Val Ala Ala  Asp Ala Gln 
    1910                 1915                 1920             


Gly Val  Phe Gln Ile Leu Ile  Arg Asn Arg Val Thr  Asp Leu Asp 
    1925                 1930                 1935             


Ala Arg  Met Asn Asp Gly Thr  Thr Pro Leu Ile Leu  Ala Ala Arg 
    1940                 1945                 1950             


Leu Ala  Val Glu Gly Met Val  Ala Glu Leu Ile Asn  Cys Gln Ala 
    1955                 1960                 1965             


Asp Val  Asn Ala Val Asp Asp  His Gly Lys Ser Ala  Leu His Trp 
    1970                 1975                 1980             


Ala Ala  Ala Val Asn Asn Val  Glu Ala Thr Leu Leu  Leu Leu Lys 
    1985                 1990                 1995             


Asn Gly  Ala Asn Arg Asp Met  Gln Asp Asn Lys Glu  Glu Thr Pro 
    2000                 2005                 2010             


Leu Phe  Leu Ala Ala Arg Glu  Gly Ser Tyr Glu Ala  Ala Lys Ile 
    2015                 2020                 2025             


Leu Leu  Asp His Phe Ala Asn  Arg Asp Ile Thr Asp  His Met Asp 
    2030                 2035                 2040             


Arg Leu  Pro Arg Asp Val Ala  Arg Asp Arg Met His  His Asp Ile 
    2045                 2050                 2055             


Val Arg  Leu Leu Asp Glu Tyr  Asn Val Thr Pro Ser  Pro Pro Gly 
    2060                 2065                 2070             


Thr Val  Leu Thr Ser Ala Leu  Ser Pro Val Ile Cys  Gly Pro Asn 
    2075                 2080                 2085             


Arg Ser  Phe Leu Ser Leu Lys  His Thr Pro Met Gly  Lys Lys Ser 
    2090                 2095                 2100             


Arg Arg  Pro Ser Ala Lys Ser  Thr Met Pro Thr Ser  Leu Pro Asn 
    2105                 2110                 2115             


Leu Ala  Lys Glu Ala Lys Asp  Ala Lys Gly Ser Arg  Arg Lys Lys 
    2120                 2125                 2130             


Ser Leu  Ser Glu Lys Val Gln  Leu Ser Glu Ser Ser  Val Thr Leu 
    2135                 2140                 2145             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Thr Tyr  Val Ser Asp 
    2150                 2155                 2160             


Thr Thr  Ser Ser Pro Met Ile  Thr Ser Pro Gly Ile  Leu Gln Ala 
    2165                 2170                 2175             


Ser Pro  Asn Pro Met Leu Ala  Thr Ala Ala Pro Pro  Ala Pro Val 
    2180                 2185                 2190             


His Ala  Gln His Ala Leu Ser  Phe Ser Asn Leu His  Glu Met Gln 
    2195                 2200                 2205             


Pro Leu  Ala His Gly Ala Ser  Thr Val Leu Pro Ser  Val Ser Gln 
    2210                 2215                 2220             


Leu Leu  Ser His His His Ile  Val Ser Pro Gly Ser  Gly Ser Ala 
    2225                 2230                 2235             


Gly Ser  Leu Ser Arg Leu His  Pro Val Pro Val Pro  Ala Asp Trp 
    2240                 2245                 2250             


Met Asn  Arg Met Glu Val Asn  Glu Thr Gln Tyr Asn  Glu Met Phe 
    2255                 2260                 2265             


Gly Met  Val Leu Ala Pro Ala  Glu Gly Thr His Pro  Gly Ile Ala 
    2270                 2275                 2280             


Pro Gln  Ser Arg Pro Pro Glu  Gly Lys His Ile Thr  Thr Pro Arg 
    2285                 2290                 2295             


Glu Pro  Leu Pro Pro Ile Val  Thr Phe Gln Leu Ile  Pro Lys Gly 
    2300                 2305                 2310             


Ser Ile  Ala Gln Pro Ala Gly  Ala Pro Gln Pro Gln  Ser Thr Cys 
    2315                 2320                 2325             


Pro Pro  Ala Val Ala Gly Pro  Leu Pro Thr Met Tyr  Gln Ile Pro 
    2330                 2335                 2340             


Glu Met  Ala Arg Leu Pro Ser  Val Ala Phe Pro Thr  Ala Met Met 
    2345                 2350                 2355             


Pro Gln  Gln Asp Gly Gln Val  Ala Gln Thr Ile Leu  Pro Ala Tyr 
    2360                 2365                 2370             


His Pro  Phe Pro Ala Ser Val  Gly Lys Tyr Pro Thr  Pro Pro Ser 
    2375                 2380                 2385             


Gln His  Ser Tyr Ala Ser Ser  Asn Ala Ala Glu Arg  Thr Pro Ser 
    2390                 2395                 2400             


His Ser  Gly His Leu Gln Gly  Glu His Pro Tyr Leu  Thr Pro Ser 
    2405                 2410                 2415             


Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser Ser Pro  His Ser Ala 
    2420                 2425                 2430             


Ser Asp  Trp Ser Asp Val Thr  Thr Ser Pro Thr Pro  Gly Gly Ala 
    2435                 2440                 2445             


Gly Gly  Gly Gln Arg Gly Pro  Gly Thr His Met Ser  Glu Pro Pro 
    2450                 2455                 2460             


His Asn  Asn Met Gln Val Tyr  Ala 
    2465                 2470     


<210>  713
<211>  1364
<212>  DNA
<213>  Homo sapiens

<400>  713
aggctgcttc gttgcacacc cgagaaagtt tcagccaaac ttcgggcggc ggctgaggcg       60

gcggccgagg agcggcggac tcggggcgcg gggagtcgag gcatttgcgc ctgggcttcg      120

gagcgtagcg ccagggcctg agcctttgaa gcaggaggag gggaggagag agtggggctc      180

ctctatcggg accccctccc catgtggatc tgcccaggcg gcggcggcgg cggcggagga      240

ggaggcgacc gagaagatgc ccgccctgcg ccccgctctg ctgtgggcgc tgctggcgct      300

ctggctgtgc tgcgcggccc ccgcgcatgc attgcagtgt cgagatggct atgaaccctg      360

tgtaaatgaa ggaatgtgtg ttacctacca caatggcaca ggatactgca aatgtccaga      420

aggcttcttg ggggaatatt gtcaacatcg agacccctgt gagaagaacc gctgccagaa      480

tggtgggact tgtgtggccc aggccatgct ggggaaagcc acgtgccgat gtgcctcagg      540

gtttacagga gaggactgcc agtactcaac atctcatcca tgctttgtgt ctcgaccctg      600

cctgaatggc ggcacatgcc atatgctcag ccgggatacc tatgagtgca cctgtcaagt      660

cgggtttaca ggtaaggagt gccaatggac ggatgcctgc ctgtctcatc cctgtgcaaa      720

tggaagtacc tgtaccactg tggccaacca gttctcctgc aaatgcctca caggcttcac      780

agggcagaaa tgtgagactg atgtcaatga gtgtgacatt ccaggacact gccagcatgg      840

tggcacctgc ctcaacctgc ctggttccta ccagtgccag tgccctcagg gcttcacagg      900

ccagtactgt gacagcctgt atgtgccctg tgcaccctca ccttgtgtca atggaggcac      960

ctgtcggcag actggtgact tcacttttga gtgcaactgc cttccaggtt ttgaagggag     1020

cacctgtgag aggaatattg atgactgccc taaccacagg tgtcagaatg gaggggtttg     1080

tgtggatggg gtcaacactt acaactgccg ctgtccccca caatggacag gacagttctg     1140

cacagaggat gtggatgaat gcctgctgca gcccaatgcc tgtcaaaatg ggggcacctg     1200

tgccaaccgc aatggaggct atggctgtgt atgtgtcaac ggctggagtg gagatgactg     1260

cagtgagaac attgatgatt gtgccttcgc ctcctgtact ccaggctcca cctgcatcga     1320

ccgtgtggcc tccttctctt gcatgtgccc agaggggaag gcag                      1364


<210>  714
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  714

Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      


Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          


Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              


Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  


Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  


Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      


Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         


Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             


Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 


Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 


Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     


Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         


Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             


Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 


Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 


Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     


Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         


Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             


Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 


Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 


Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     


Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         


Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             


Ala 
    


<210>  715
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  715
agggccggct ggacaaactg acagtcacct cccagaacct gcagctggag aacctgcgca       60

tgaagcttcc caagc                                                        75


<210>  716
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  716
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaa                                                        75


<210>  717
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  717
agggccggct ggacaaactg acagtcacct cccagaacct gcagctggag aacctgcgca       60

tgaagcttcc caagcccttg cctccccgat tgaaagagat gaaaagccag gaatcggctg      120

caggttccaa actagtcctt cggtgtgaaa                                       150


<210>  718
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  718

Gly Arg Leu Asp Lys Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu 
1               5                   10                  15      


Asn Leu Arg Met Lys Leu Pro Lys Pro Leu Pro Pro Arg Leu Lys Glu 
            20                  25                  30          


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
        35                  40                  45              


Glu 
    


<210>  719
<211>  286
<212>  DNA
<213>  Homo sapiens

<400>  719
atcctgcccc gcaaaaggca gcttcaccaa agtggggtat ttccagcctt tgtagctttc       60

acttccacat ctaccaagtg ggcggagtgg ccttctgtgg acgaatcaga ttcctctcca      120

gcaccgactt taagaggcga gccggggggt cagggtccca gatgcacagg aggagaagca      180

ggagctgtcg ggaagatcag aagccagtca tggatgacca gcgcgacctt atctccaaca      240

atgagcaact gcccatgctg ggccggcgcc ctggggcccc ggagag                     286


<210>  720
<211>  173
<212>  DNA
<213>  Homo sapiens

<400>  720
caagtgcagc cgcggagccc tgtacacagg cttttccatc ctggtgactc tgctcctcgc       60

tggccaggcc accaccgcct acttcctgta ccagcagcag ggccggctgg acaaactgac      120

agtcacctcc cagaacctgc agctggagaa cctgcgcatg aagcttccca agc             173


<210>  721
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  721
ctcccaagcc tgtgagcaag atgcgcatgg ccaccccgct gctgatgcag gcgctgccca       60

tgggagccct gccccagggg                                                   80


<210>  722
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  722
cccatgcaga atgccaccaa gtatggcaac atgacagagg accatgtgat gcacctgctc       60

cag                                                                     63


<210>  723
<211>  96
<212>  DNA
<213>  Homo sapiens

<400>  723
aatgctgacc ccctgaaggt gtacccgcca ctgaagggga gcttcccgga gaacctgaga       60

caccttaaga acaccatgga gaccatagac tggaag                                 96


<210>  724
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  724
gtctttgaga gctggatgca ccattggctc ctgtttgaaa tgagcaggca ctccttggag       60

caaaagccca ctgacgctcc accgaaag                                          88


<210>  725
<211>  192
<212>  DNA
<213>  Homo sapiens

<400>  725
tactgaccaa gtgccaggaa gaggtcagcc acatccctgc tgtccacccg ggttcattca       60

ggcccaagtg cgacgagaac ggcaactatc tgccactcca gtgctatggg agcatcggct      120

actgctggtg tgtcttcccc aacggcacgg aggtccccaa caccagaagc cgcgggcacc      180

ataactgcag tg                                                          192


<210>  726
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  726
agtcactgga actggaggac ccgtcttctg ggctgggtgt gaccaagcag gatctgggcc       60

cag                                                                     63


<210>  727
<211>  612
<212>  DNA
<213>  Homo sapiens

<400>  727
tccccatgtg agagcagcag aggcggtctt caacatcctg ccagccccac acagctacag       60

ctttcttgct cccttcagcc cccagcccct cccccatctc ccaccctgta cctcatccca      120

tgagaccctg gtgcctggct ctttcgtcac ccttggacaa gacaaaccaa gtcggaacag      180

cagataacaa tgcagcaagg ccctgctgcc caatctccat ctgtcaacag gggcgtgagg      240

tcccaggaag tggccaaaag ctagacagat ccccgttcct gacatcacag cagcctccaa      300

cacaaggctc caagacctag gctcatggac gagatgggaa ggcacaggga gaagggataa      360

ccctacaccc agaccccagg ctggacatgc tgactgtcct ctcccctcca gcctttggcc      420

ttggcttttc tagcctattt acctgcaggc tgagccactc tcttcccttt ccccagcatc      480

actccccaag gaagagccaa tgttttccac ccataatcct ttctgccgac ccctagttcc      540

ctctgctcag ccaagcttgt tatcagcttt cagggccatg gttcacatta gaataaaagg      600

tagtaattag aa                                                          612


<210>  728
<211>  1653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of CD74

<400>  728
atcctgcccc gcaaaaggca gcttcaccaa agtggggtat ttccagcctt tgtagctttc       60

acttccacat ctaccaagtg ggcggagtgg ccttctgtgg acgaatcaga ttcctctcca      120

gcaccgactt taagaggcga gccggggggt cagggtccca gatgcacagg aggagaagca      180

ggagctgtcg ggaagatcag aagccagtca tggatgacca gcgcgacctt atctccaaca      240

atgagcaact gcccatgctg ggccggcgcc ctggggcccc ggagagcaag tgcagccgcg      300

gagccctgta cacaggcttt tccatcctgg tgactctgct cctcgctggc caggccacca      360

ccgcctactt cctgtaccag cagcagggcc ggctggacaa actgacagtc acctcccaga      420

acctgcagct ggagaacctg cgcatgaagc ttcccaagcc tcccaagcct gtgagcaaga      480

tgcgcatggc caccccgctg ctgatgcagg cgctgcccat gggagccctg ccccaggggc      540

ccatgcagaa tgccaccaag tatggcaaca tgacagagga ccatgtgatg cacctgctcc      600

agaatgctga ccccctgaag gtgtacccgc cactgaaggg gagcttcccg gagaacctga      660

gacaccttaa gaacaccatg gagaccatag actggaaggt ctttgagagc tggatgcacc      720

attggctcct gtttgaaatg agcaggcact ccttggagca aaagcccact gacgctccac      780

cgaaagtact gaccaagtgc caggaagagg tcagccacat ccctgctgtc cacccgggtt      840

cattcaggcc caagtgcgac gagaacggca actatctgcc actccagtgc tatgggagca      900

tcggctactg ctggtgtgtc ttccccaacg gcacggaggt ccccaacacc agaagccgcg      960

ggcaccataa ctgcagtgag tcactggaac tggaggaccc gtcttctggg ctgggtgtga     1020

ccaagcagga tctgggccca gtccccatgt gagagcagca gaggcggtct tcaacatcct     1080

gccagcccca cacagctaca gctttcttgc tcccttcagc ccccagcccc tcccccatct     1140

cccaccctgt acctcatccc atgagaccct ggtgcctggc tctttcgtca cccttggaca     1200

agacaaacca agtcggaaca gcagataaca atgcagcaag gccctgctgc ccaatctcca     1260

tctgtcaaca ggggcgtgag gtcccaggaa gtggccaaaa gctagacaga tccccgttcc     1320

tgacatcaca gcagcctcca acacaaggct ccaagaccta ggctcatgga cgagatggga     1380

aggcacaggg agaagggata accctacacc cagaccccag gctggacatg ctgactgtcc     1440

tctcccctcc agcctttggc cttggctttt ctagcctatt tacctgcagg ctgagccact     1500

ctcttccctt tccccagcat cactccccaa ggaagagcca atgttttcca cccataatcc     1560

tttctgccga cccctagttc cctctgctca gccaagcttg ttatcagctt tcagggccat     1620

ggttcacatt agaataaaag gtagtaatta gaa                                  1653


<210>  729
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  729

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu 
        35                  40      


<210>  730
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  730

Lys Cys Ser Arg Gly Ala Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr 
1               5                   10                  15      


Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln 
            20                  25                  30          


Gln Gly Arg Leu Asp Lys Leu Thr Val Thr Ser Gln Asn Leu Gln Leu 
        35                  40                  45              


Glu Asn Leu Arg Met Lys Leu Pro Lys 
    50                  55          


<210>  731
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  731

Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu Met Gln 
1               5                   10                  15      


Ala Leu Pro Met Gly Ala Leu Pro Gln Gly 
            20                  25      


<210>  732
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  732

Pro Met Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val 
1               5                   10                  15      


Met His Leu Leu Gln 
            20      


<210>  733
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  733

Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly Ser Phe Pro 
1               5                   10                  15      


Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile Asp Trp Lys 
            20                  25                  30          


<210>  734
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  734

Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu Met Ser Arg 
1               5                   10                  15      


His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
            20                  25                  


<210>  735
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  735

Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His Pro 
1               5                   10                  15      


Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro Leu 
            20                  25                  30          


Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn Gly 
        35                  40                  45              


Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
    50                  55                  60              


<210>  736
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  736

Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys Gln 
1               5                   10                  15      


Asp Leu Gly Pro 
            20  


<210>  737
<211>  2
<212>  PRT
<213>  Homo sapiens

<400>  737

Pro Met 
1       


<210>  738
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  738

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys Pro Pro Lys Pro Val Ser Lys Met Arg Met Ala Thr Pro 
            100                 105                 110         


Leu Leu Met Gln Ala Leu Pro Met Gly Ala Leu Pro Gln Gly Pro Met 
        115                 120                 125             


Gln Asn Ala Thr Lys Tyr Gly Asn Met Thr Glu Asp His Val Met His 
    130                 135                 140                 


Leu Leu Gln Asn Ala Asp Pro Leu Lys Val Tyr Pro Pro Leu Lys Gly 
145                 150                 155                 160 


Ser Phe Pro Glu Asn Leu Arg His Leu Lys Asn Thr Met Glu Thr Ile 
                165                 170                 175     


Asp Trp Lys Val Phe Glu Ser Trp Met His His Trp Leu Leu Phe Glu 
            180                 185                 190         


Met Ser Arg His Ser Leu Glu Gln Lys Pro Thr Asp Ala Pro Pro Lys 
        195                 200                 205             


Val Leu Thr Lys Cys Gln Glu Glu Val Ser His Ile Pro Ala Val His 
    210                 215                 220                 


Pro Gly Ser Phe Arg Pro Lys Cys Asp Glu Asn Gly Asn Tyr Leu Pro 
225                 230                 235                 240 


Leu Gln Cys Tyr Gly Ser Ile Gly Tyr Cys Trp Cys Val Phe Pro Asn 
                245                 250                 255     


Gly Thr Glu Val Pro Asn Thr Arg Ser Arg Gly His His Asn Cys Ser 
            260                 265                 270         


Glu Ser Leu Glu Leu Glu Asp Pro Ser Ser Gly Leu Gly Val Thr Lys 
        275                 280                 285             


Gln Asp Leu Gly Pro Val Pro Met 
    290                 295     


<210>  739
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  739
atcctgcccc gcaaaaggca gcttcaccaa agtggggtat ttccagcctt tgtagctttc       60

acttccacat ctaccaagtg ggcggagtgg ccttctgtgg acgaatcaga ttcctctcca      120

gcaccgactt taagaggcga gccggggggt cagggtccca gatgcacagg aggagaagca      180

ggagctgtcg ggaagatcag aagccagtca tggatgacca gcgcgacctt atctccaaca      240

atgagcaact gcccatgctg ggccggcgcc ctggggcccc ggagagcaag tgcagccgcg      300

gagccctgta cacaggcttt tccatcctgg tgactctgct cctcgctggc caggccacca      360

ccgcctactt cctgtaccag cagcagggcc ggctggacaa actgacagtc acctcccaga      420

acctgcagct ggagaacctg cgcatgaagc ttcccaagc                             459


<210>  740
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  740

Met His Arg Arg Arg Ser Arg Ser Cys Arg Glu Asp Gln Lys Pro Val 
1               5                   10                  15      


Met Asp Asp Gln Arg Asp Leu Ile Ser Asn Asn Glu Gln Leu Pro Met 
            20                  25                  30          


Leu Gly Arg Arg Pro Gly Ala Pro Glu Ser Lys Cys Ser Arg Gly Ala 
        35                  40                  45              


Leu Tyr Thr Gly Phe Ser Ile Leu Val Thr Leu Leu Leu Ala Gly Gln 
    50                  55                  60                  


Ala Thr Thr Ala Tyr Phe Leu Tyr Gln Gln Gln Gly Arg Leu Asp Lys 
65                  70                  75                  80  


Leu Thr Val Thr Ser Gln Asn Leu Gln Leu Glu Asn Leu Arg Met Lys 
                85                  90                  95      


Leu Pro Lys 
            


<210>  741
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  741
taccagacga tgaggatgta gtggggcccg ggcaggaatc tgatgacttt gagctgtctg       60

gctctggaga tctgg                                                        75


<210>  742
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  742
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaa                                                        75


<210>  743
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  743
taccagacga tgaggatgta gtggggcccg ggcaggaatc tgatgacttt gagctgtctg       60

gctctggaga tctggccttg cctccccgat tgaaagagat gaaaagccag gaatcggctg      120

caggttccaa actagtcctt cggtgtgaaa                                       150


<210>  744
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  744

Pro Asp Asp Glu Asp Val Val Gly Pro Gly Gln Glu Ser Asp Asp Phe 
1               5                   10                  15      


Glu Leu Ser Gly Ser Gly Asp Leu Ala Leu Pro Pro Arg Leu Lys Glu 
            20                  25                  30          


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
        35                  40                  45              


Glu 
    


<210>  745
<211>  100
<212>  DNA
<213>  Homo sapiens

<400>  745
actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt       60

cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg                            100


<210>  746
<211>  139
<212>  DNA
<213>  Homo sapiens

<400>  746
atccgagaga ctgaggtcat cgacccccag gacctcctag aaggccgata cttctccgga       60

gccctaccag acgatgagga tgtagtgggg cccgggcagg aatctgatga ctttgagctg      120

tctggctctg gagatctgg                                                   139


<210>  747
<211>  47
<212>  DNA
<213>  Homo sapiens

<400>  747
atgacttgga agactccatg atcggccctg aagttgtcca tcccttg                     47


<210>  748
<211>  199
<212>  DNA
<213>  Homo sapiens

<400>  748
gtgcctctag ataaccatat ccctgagagg gcagggtctg ggagccaagt ccccaccgaa       60

cccaagaaac tagaggagaa tgaggttatc cccaagagaa tctcacccgt tgaagagagt      120

gaggatgtgt ccaacaaggt gtcaatgtcc agcactgtgc agggcagcaa catctttgag      180

agaacggagg tcctggcag                                                   199


<210>  749
<211>  2128
<212>  DNA
<213>  Homo sapiens

<400>  749
ctctgattgt gggtggcatc gtgggcatcc tctttgccgt cttcctgatc ctactgctca       60

tgtaccgtat gaagaagaag gatgaaggca gctatgacct gggcaagaaa cccatctaca      120

agaaagcccc caccaatgag ttctacgcgt gaagcttgct tgtgggcact ggcttggact      180

ttagcgggga gggaagccag gggattttga agggtggaca ttagggtagg gtgaggtcaa      240

cctaatactg acttgtcagt atctccagct ctgattacct ttgaagtgtt cagaagagac      300

attgtcttct actgttctgc caggttcttc ttgagctttg ggcctcagtt gccctggcag      360

aaaaatggat tcaacttggc ctttctgaag gcaagactgg gattggatca cttcttaaac      420

ttccagttaa gaatctaggt ccgccctcaa gcccatactg accatgcctc atccagagct      480

cctctgaagc cagggggcta acggatgttg tgtggagtcc tggctggagg tcctccccca      540

gtggccttcc tcccttcctt tcacagccgg tctctctgcc aggaaatggg ggaaggaact      600

agaaccacct gcaccttgag atgtttctgt aaatgggtac ttgtgatcac actacgggaa      660

tctctgtggt atatacctgg ggccattcta ggctctttca agtgactttt ggaaatcaac      720

cttttttatt tgggggggag gatggggaaa agagctgaga gtttatgctg aaatggattt      780

atagaatatt tgtaaatcta tttttagtgt ttgttcgttt ttttaactgt tcattccttt      840

gtgcagagtg tatatctctg cctgggcaag agtgtggagg tgccgaggtg tcttcattct      900

ctcgcacatt tccacagcac ctgctaagtt tgtatttaat ggtttttgtt tttgtttttg      960

tttgtttctt gaaaatgaga gaagagccgg agagatgatt tttattaatt tttttttttt     1020

tttttttttt ttactattta tagctttaga tagggcctcc cttcccctct tctttctttg     1080

ttctctttca ttaaacccct tccccagttt tttttttata ctttaaaccc cgctcctcat     1140

ggccttggcc ctttctgaag ctgcttcctc ttataaaata gcttttgccg aaacatagtt     1200

tttttttagc agatcccaaa atataatgaa ggggatggtg ggatatttgt gtctgtgttc     1260

ttataatata ttattattct tccttggttc tagaaaaata gataaatata tttttttcag     1320

gaaatagtgt ggtgtttcca gtttgatgtt gctgggtggt tgagtgagtg aattttcatg     1380

tggctgggtg ggtttttgcc tttttctctt gccctgttcc tggtgccttc tgatggggct     1440

ggaatagttg aggtggatgg ttctaccctt tctgccttct gtttgggacc cagctggtgt     1500

tctttggttt gctttcttca ggctctaggg ctgtgctatc caatacagta accacatgcg     1560

gctgtttaaa gttaagccaa ttaaaatcac ataagattaa aaattccttc ctcagttgca     1620

ctaaccacgt ttctagaggc gtcactgtat gtagttcatg gctactgtac tgacagcgag     1680

agcatgtcca tctgttggac agcactattc tagagaacta aactggctta acgagtcaca     1740

gcctcagctg tgctgggacg acccttgtct ccctgggtag ggggggggga atgggggagg     1800

gctgatgagg ccccagctgg ggcctgttgt ctgggaccct ccctctcctg agaggggagg     1860

cctggtggct tagcctgggc aggtcgtgtc tcctcctgac cccagtggct gcggtgaggg     1920

gaaccaccct cccttgctgc accagtggcc attagctccc gtcaccactg caacccaggg     1980

tcccagctgg ctgggtcctc ttctgccccc agtgcccttc cccttgggct gtgttggagt     2040

gagcacctcc tctgtaggca cctctcacac tgttgtctgt tactgatttt ttttgataaa     2100

aagataataa aacctggtac tttctaaa                                        2128


<210>  750
<211>  2613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of SDC4

<400>  750
actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt       60

cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg atccgagaga ctgaggtcat      120

cgacccccag gacctcctag aaggccgata cttctccgga gccctaccag acgatgagga      180

tgtagtgggg cccgggcagg aatctgatga ctttgagctg tctggctctg gagatctgga      240

tgacttggaa gactccatga tcggccctga agttgtccat cccttggtgc ctctagataa      300

ccatatccct gagagggcag ggtctgggag ccaagtcccc accgaaccca agaaactaga      360

ggagaatgag gttatcccca agagaatctc acccgttgaa gagagtgagg atgtgtccaa      420

caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa cggaggtcct      480

ggcagctctg attgtgggtg gcatcgtggg catcctcttt gccgtcttcc tgatcctact      540

gctcatgtac cgtatgaaga agaaggatga aggcagctat gacctgggca agaaacccat      600

ctacaagaaa gcccccacca atgagttcta cgcgtgaagc ttgcttgtgg gcactggctt      660

ggactttagc ggggagggaa gccaggggat tttgaagggt ggacattagg gtagggtgag      720

gtcaacctaa tactgacttg tcagtatctc cagctctgat tacctttgaa gtgttcagaa      780

gagacattgt cttctactgt tctgccaggt tcttcttgag ctttgggcct cagttgccct      840

ggcagaaaaa tggattcaac ttggcctttc tgaaggcaag actgggattg gatcacttct      900

taaacttcca gttaagaatc taggtccgcc ctcaagccca tactgaccat gcctcatcca      960

gagctcctct gaagccaggg ggctaacgga tgttgtgtgg agtcctggct ggaggtcctc     1020

ccccagtggc cttcctccct tcctttcaca gccggtctct ctgccaggaa atgggggaag     1080

gaactagaac cacctgcacc ttgagatgtt tctgtaaatg ggtacttgtg atcacactac     1140

gggaatctct gtggtatata cctggggcca ttctaggctc tttcaagtga cttttggaaa     1200

tcaacctttt ttatttgggg gggaggatgg ggaaaagagc tgagagttta tgctgaaatg     1260

gatttataga atatttgtaa atctattttt agtgtttgtt cgttttttta actgttcatt     1320

cctttgtgca gagtgtatat ctctgcctgg gcaagagtgt ggaggtgccg aggtgtcttc     1380

attctctcgc acatttccac agcacctgct aagtttgtat ttaatggttt ttgtttttgt     1440

ttttgtttgt ttcttgaaaa tgagagaaga gccggagaga tgatttttat taattttttt     1500

tttttttttt tttttttact atttatagct ttagataggg cctcccttcc cctcttcttt     1560

ctttgttctc tttcattaaa ccccttcccc agtttttttt ttatacttta aaccccgctc     1620

ctcatggcct tggccctttc tgaagctgct tcctcttata aaatagcttt tgccgaaaca     1680

tagttttttt ttagcagatc ccaaaatata atgaagggga tggtgggata tttgtgtctg     1740

tgttcttata atatattatt attcttcctt ggttctagaa aaatagataa atatattttt     1800

ttcaggaaat agtgtggtgt ttccagtttg atgttgctgg gtggttgagt gagtgaattt     1860

tcatgtggct gggtgggttt ttgccttttt ctcttgccct gttcctggtg ccttctgatg     1920

gggctggaat agttgaggtg gatggttcta ccctttctgc cttctgtttg ggacccagct     1980

ggtgttcttt ggtttgcttt cttcaggctc tagggctgtg ctatccaata cagtaaccac     2040

atgcggctgt ttaaagttaa gccaattaaa atcacataag attaaaaatt ccttcctcag     2100

ttgcactaac cacgtttcta gaggcgtcac tgtatgtagt tcatggctac tgtactgaca     2160

gcgagagcat gtccatctgt tggacagcac tattctagag aactaaactg gcttaacgag     2220

tcacagcctc agctgtgctg ggacgaccct tgtctccctg ggtagggggg ggggaatggg     2280

ggagggctga tgaggcccca gctggggcct gttgtctggg accctccctc tcctgagagg     2340

ggaggcctgg tggcttagcc tgggcaggtc gtgtctcctc ctgaccccag tggctgcggt     2400

gaggggaacc accctccctt gctgcaccag tggccattag ctcccgtcac cactgcaacc     2460

cagggtccca gctggctggg tcctcttctg cccccagtgc ccttcccctt gggctgtgtt     2520

ggagtgagca cctcctctgt aggcacctct cacactgttg tctgttactg attttttttg     2580

ataaaaagat aataaaacct ggtactttct aaa                                  2613


<210>  751
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  751

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser 
            20  


<210>  752
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  752

Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu Leu Glu Gly Arg 
1               5                   10                  15      


Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val Val Gly Pro Gly 
            20                  25                  30          


Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly Asp Leu 
        35                  40                  45      


<210>  753
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  753

Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His Pro Leu 
1               5                   10                  15  


<210>  754
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  754

Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly Ser Gln 
1               5                   10                  15      


Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile Pro Lys 
            20                  25                  30          


Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys Val Ser 
        35                  40                  45              


Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr Glu Val 
    50                  55                  60                  


Leu Ala 
65      


<210>  755
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  755

Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe Ala Val Phe Leu Ile 
1               5                   10                  15      


Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Asp 
            20                  25                  30          


Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro Thr Asn Glu Phe Tyr 
        35                  40                  45              


Ala 
    


<210>  756
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  756

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe 
145                 150                 155                 160 


Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp 
                165                 170                 175     


Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro 
            180                 185                 190         


Thr Asn Glu Phe Tyr Ala 
        195             


<210>  757
<211>  239
<212>  DNA
<213>  Homo sapiens

<400>  757
actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt       60

cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg atccgagaga ctgaggtcat      120

cgacccccag gacctcctag aaggccgata cttctccgga gccctaccag acgatgagga      180

tgtagtgggg cccgggcagg aatctgatga ctttgagctg tctggctctg gagatctgg       239


<210>  758
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  758

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu 
65      


<210>  759
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  759
tttctactgt acaccccatc ccagacgaag acagtccctg gatcaccgac agcacagaca       60

gaatccctgc tacca                                                        75


<210>  760
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  760
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatg                                                        75


<210>  761
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  761
tttctactgt acaccccatc ccagacgaag acagtccctg gatcaccgac agcacagaca       60

gaatccctgc taccactaca tctacatcca ccactgggac aagccatctt gtaaaatgtg      120

cggagaagga gaaaactttc tgtgtgaatg                                       150


<210>  762
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  762

Ser Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr Asp 
1               5                   10                  15      


Ser Thr Asp Arg Ile Pro Ala Thr Thr Thr Ser Thr Ser Thr Thr Gly 
            20                  25                  30          


Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val 
        35                  40                  45              


Asn 
    


<210>  763
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  763
actaccccat caactccaac ttcaaagtgg gctacaacac tctcttttcc tgtacctgtg       60

tgccacctga cccag                                                        75


<210>  764
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  764
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatg                                                        75


<210>  765
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  765
actaccccat caactccaac ttcaaagtgg gctacaacac tctcttttcc tgtacctgtg       60

tgccacctga cccagctaca tctacatcca ccactgggac aagccatctt gtaaaatgtg      120

cggagaagga gaaaactttc tgtgtgaatg                                       150


<210>  766
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  766

Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu Phe Ser 
1               5                   10                  15      


Cys Thr Cys Val Pro Pro Asp Pro Ala Thr Ser Thr Ser Thr Thr Gly 
            20                  25                  30          


Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val 
        35                  40                  45              


Asn 
    


<210>  767
<211>  143
<212>  DNA
<213>  Homo sapiens

<400>  767
ggcggcgcgc cgggcagcgc ttcggtggcg gcggcggccg cggtggcagc gaaggcggcg       60

gcggcggcgg cagtggcagt ggccgctgca gccccacact ccgccgccaa actggaggag      120

cgacggaagc cagaccccag gag                                              143


<210>  768
<211>  74
<212>  DNA
<213>  Homo sapiens

<400>  768
gatggaggat gaagctgtcc tggacagagg ggcttccttc ctcaagcatg tgtgtgatga       60

agaagaagta gaag                                                         74


<210>  769
<211>  180
<212>  DNA
<213>  Homo sapiens

<400>  769
gccaccatac catttacatc ggagtccatg tgccgaagag ttacaggaga aggagacgtc       60

acaagagaaa gacagggcac aaagaaaaga aggaaaagga gagaatctct gagaactact      120

ctgacaaatc agatattgaa aatgctgatg aatccagcag cagcatccta aaacctctca      180


<210>  770
<211>  136
<212>  DNA
<213>  Homo sapiens

<400>  770
tctctcctgc tgcagaacgc atccgattca tcttgggaga ggaggatgac agcccagctc       60

cccctcagct cttcacggaa ctggatgagc tgctggccgt ggatgggcag gagatggagt      120

ggaaggaaac agccag                                                      136


<210>  771
<211>  161
<212>  DNA
<213>  Homo sapiens

<400>  771
gtggatcaag tttgaagaaa aagtggaaca gggtggggaa agatggagca agccccatgt       60

ggccacattg tcccttcata gtttatttga gctgaggaca tgtatggaga aaggatccat      120

catgcttgat cgggaggctt cttctctccc acagttggtg g                          161


<210>  772
<211>  180
<212>  DNA
<213>  Homo sapiens

<400>  772
agatgattgt tgaccatcag attgagacag gcctattgaa acctgaactt aaggataagg       60

tgacctatac tttgctccgg aagcaccggc atcaaaccaa gaaatccaac cttcggtccc      120

tggctgacat tgggaagaca gtctccagtg caagtaggat gtttaccaac cctgataatg      180


<210>  773
<211>  77
<212>  DNA
<213>  Homo sapiens

<400>  773
gtagcccagc catgacccat aggaatctga cttcctccag tctgaatgac atttctgata       60

aaccggagaa ggaccag                                                      77


<210>  774
<211>  158
<212>  DNA
<213>  Homo sapiens

<400>  774
ctgaagaata agttcatgaa aaaattgcca cgtgatgcag aagcttccaa cgtgcttgtt       60

ggggaggttg actttttgga tactcctttc attgcctttg ttaggctaca gcaggctgtc      120

atgctgggtg ccctgactga agttcctgtg cccacaag                              158


<210>  775
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  775
gttcttgttc attctcttag gtcctaaggg gaaagccaag tcctaccacg agattggcag       60

agccattgcc accctgatgt ctgatgag                                          88


<210>  776
<211>  155
<212>  DNA
<213>  Homo sapiens

<400>  776
gtgttccatg acattgctta taaagcaaaa gacaggcacg acctgattgc tggtattgat       60

gagttcctag atgaagtcat cgtccttcca cctggggaat gggatccagc aattaggata      120

gagcctccta agagtcttcc atcctctgac aaaag                                 155


<210>  777
<211>  114
<212>  DNA
<213>  Homo sapiens

<400>  777
aaagaatatg tactcaggtg gagagaatgt tcagatgaat ggggatacgc cccatgatgg       60

aggtcacgga ggaggaggac atggggattg tgaagaattg cagcgaactg gacg            114


<210>  778
<211>  175
<212>  DNA
<213>  Homo sapiens

<400>  778
gttctgtggt ggactaatta aagacataaa gaggaaagcg ccattttttg ccagtgattt       60

ttatgatgct ttaaatattc aagctctttc ggcaattctc ttcatttatc tggcaactgt      120

aactaatgct atcacttttg gaggactgct tggggatgcc actgacaaca tgcag           175


<210>  779
<211>  134
<212>  DNA
<213>  Homo sapiens

<400>  779
ggcgtgttgg agagtttcct gggcactgct gtctctggag ccatcttttg cctttttgct       60

ggtcaaccac tcactattct gagcagcacc ggacctgtcc tagtttttga gaggcttcta      120

tttaatttca gcaa                                                        134


<210>  780
<211>  272
<212>  DNA
<213>  Homo sapiens

<400>  780
ggacaataat tttgactatt tggagtttcg cctttggatt ggcctgtggt ccgccttcct       60

atgtctcatt ttggtagcca ctgatgccag cttcttggtt caatacttca cacgtttcac      120

ggaggagggc ttttcctctc tgattagctt catctttatc tatgatgctt tcaagaagat      180

gatcaagctt gcagattact accccatcaa ctccaacttc aaagtgggct acaacactct      240

cttttcctgt acctgtgtgc cacctgaccc ag                                    272


<210>  781
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  781
ctaatatctc aatatctaat gacaccacac tggccccaga gtatttgcca actatgtctt       60

ctactgacat g                                                            71


<210>  782
<211>  192
<212>  DNA
<213>  Homo sapiens

<400>  782
taccataata ctacctttga ctgggcattt ttgtcgaaga aggagtgttc aaaatacgga       60

ggaaacctcg tcgggaacaa ctgtaatttt gttcctgata tcacactcat gtcttttatc      120

ctcttcttgg gaacctacac ctcttccatg gctctgaaaa aattcaaaac tagtccttat      180

tttccaacca ca                                                          192


<210>  783
<211>  114
<212>  DNA
<213>  Homo sapiens

<400>  783
gcaagaaaac tgatcagtga ttttgccatt atcttgtcca ttctcatctt ttgtgtaata       60

gatgccctag taggcgtgga caccccaaaa ctaattgtgc caagtgagtt caag            114


<210>  784
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  784
ccaacaagtc caaaccgagg ttggttcgtt ccaccgtttg gagaaaaccc ctggtgggtg       60

tgccttgctg ctgctatccc ggctttgttg gtcactatac tgattttcat ggaccaacaa      120

attacagctg tgattgtaaa caggaaagaa cataaactca ag                         162


<210>  785
<211>  179
<212>  DNA
<213>  Homo sapiens

<400>  785
aaaggagcag ggtatcactt ggatctcttt tgggtggcca tcctcatggt tatatgctcc       60

ctcatggctc ttccgtggta tgtagctgct acggtcatct ccattgctca catcgacagt      120

ttgaagatgg agacagagac ttctgcacct ggagaacaac caaagtttct aggagtgag       179


<210>  786
<211>  73
<212>  DNA
<213>  Homo sapiens

<400>  786
ggaacaaaga gtcactggaa cccttgtgtt tattctgact ggtctgtcag tctttatggc       60

tcccatcttg aag                                                          73


<210>  787
<211>  70
<212>  DNA
<213>  Homo sapiens

<400>  787
gtttataccc atgcctgtac tctatggtgt gttcctgtat atgggagtag catcccttaa       60

tggtgtgcag                                                              70


<210>  788
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  788
ttcatggatc gtctgaagct gcttctgatg cctctgaagc atcagcctga cttcatctac       60

ctgcgtcatg ttcctctgcg cagagtccac ctgttcactt tcctgcaggt gttgtgtctg      120

gccctgcttt ggatcctcaa gtcaacggtg gctgctatca tttttccagt aatg            174


<210>  789
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  789
atcttggcac ttgtagctgt cagaaaaggc atggactacc tcttctccca gcacgacctc       60

agcttcctgg atgatgtcat tccagaaaag gacaagaaaa agaaggagga tgagaagaaa      120

aagaaaaaga agaagggaag tctggacagt gacaatgatg at                         162


<210>  790
<211>  97
<212>  DNA
<213>  Homo sapiens

<400>  790
tctgactgcc catactcaga aaaagttcca agtattaaaa ttccaatgga catcatggaa       60

cagcaacctt tcctaagcga tagcaaacct tctgaca                                97


<210>  791
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  791
gagaaagatc accaacattc cttgaacgcc acacatcatg ctgataaaat tcctttcctt       60

cagtcactcg gtatgccaag                                                   80


<210>  792
<211>  4296
<212>  DNA
<213>  Homo sapiens

<400>  792
tcctcctaga actccagtaa aagttgtgcc tcaaattaga atagaacttg aacctgaaga       60

caatgattat ttctggagga gcaagggaac agaaactaca ttgtaacctg tttgtctttc      120

ttaaaactga catttgttgt taatgtcatt tgtttttgtt tggctgtttg tttatttttt      180

aacttttatt tcgtctcagt ttttggtcac aggccaaata atacagcgct ctctctgctt      240

ctctcttgca tagacacaat caagacaata gtgcaccgtt ccttaaaaac agcatctgag      300

gaatccccct tttgttctta aactttcaga tgtgtccttt gataaccaaa ttctgtcact      360

caagacacag acacgcacag accctgtcct ttgcctctat taagcagagg atggaagtat      420

taaggatttt gtaacacctt ttatgaaaat gttgaaggaa cttaaaactt tagctttgga      480

gctgtgctta ctggcttgtc tttgtctggt agaacaaacc ttgacctcca gacagagtcc      540

cttctcactt atagagctct ccaggactgg aaaaagtgct gctattttaa cttgctcttg      600

cttgtaaatc ctaatcttag agttatcaaa agaagaaaaa actgaaggta ctttactccc      660

tatagagaaa ccattgccat cattgtagca agtgctggaa tgtccctttt ttcctatgca      720

acttttttta accctttaat gaacttatct gttgagtaca ttgaagaata tttttcttcc      780

tagattttgt tgtttaaatt atggggccta acctgccact tattttttgt caatttttaa      840

aacttttttt taattactgt aaagaaaatg aattttttcc tgcagcagga aacatagttt      900

tgagtagttc tacctcttat ttgtagctgc caggctttct gtaaaaattg tattgtatat      960

aatgtgattt ttacacatac atacacacac aaatacacaa tctctagggt aagccagaag     1020

gcaagatcag attaaaaaca ccatgtttct aagcatccat ttttcccttt ctttaaaaga     1080

aacttaactg ttctatgaag gagattgagg gagaagagac aaactcctat gtcatgagaa     1140

taaccgatgt tctgataata gtagcatcta ggtacagatg ctggttgtat taccacgtca     1200

atgtcctatg cagtattgtt agacattttc tcattttgaa atatttgtgt gtttgtgtat     1260

gtgctctgtg ccatggctgg tgtatatatg tgcaatgtta gaaggcaaaa gagtgatggt     1320

aggcagaggg caaagtcatt gaatctctta tgccagtttt cataaaaccc aaaccacata     1380

tgaaaaaatc cattaagggt ccaagaagtc tgtccatatg aaaatgaggg taaatatagt     1440

ttatttccca ggtatcagtc attataattg atataatagc tctaacatgc aatataaaat     1500

tcataggagt attaatagcc catttacaca tctataaaat gtaatgggat tgcagagctg     1560

cagagtacag tgtaacagta ctctcatgca atttttttca ggatgcaaag gcaattattc     1620

tttgtaagcg ggacatttag aatatatttg tgtacatatt atatgtatgt atatttcaaa     1680

gtaccacact gaaaattaga catttattaa ccaaatttaa cgtggtattt aaaggtaata     1740

tttttaatat gatacattac atattgtgaa tgtatactaa aaaaacattt taaatgttaa     1800

aattataatt tcagattcat ataaccacaa ctgtgatata tcctaactat aaccagttgt     1860

tgaggggtat actagaagca gaatgaaacc acattttttg gtttgataat atgcacttat     1920

tgactcccac tcattgttat gttaattaag ttattattct gtctccttgt aattttgatt     1980

acaaaaattt tattatcctg agttagctgt tacttttaca gtacctgata ctcctaaaac     2040

ttttaactta tacaaattag tcaataatga ccccaatttt ttcattaaaa taatagtggt     2100

gaattatatg ttattgtgtt aaaacctcac ttgccaaatt ctggcttcac atttgtattt     2160

agggctatcc ttaaaatgat gagtctatat tatctagctt tctattaccc taatataaac     2220

tggtataaga agactttcct tttttcttta tgcatggaag catcaataaa ttgtttaaaa     2280

accatgtata gtaaattcag cttaacccgt gatcttctta agttaaaggt acttttgttt     2340

tataaaagct ctagataaaa ctttcttttc tgatcatgaa tcaagtatct gtggtttcat     2400

gcccctctct atacctttca aagaactcct gaagcaactt aactcatcat ttcagcctct     2460

gagtagaggt aaaacctatg tgtacttctg tttatgatcc atattgatat ttatgacatg     2520

aacacagaat agtaccttac atttgctaaa cagacagtta atatcaaatc ctttcaatat     2580

tctgggaacc cagggaagtt tttaaaaatg tcattacttt caaaggaaca gaagtagtta     2640

accaaactaa caagcaaaac ctgaggttta cctagtgaca ccaaattatc ggtattttaa     2700

ctgaatttac ccattgacta agaatgaacc agatttggtg gtggttttgt ttctatgcaa     2760

actggacaca aattacaaca gtaaattttt ttataagtgc ttctcccttc tccatgatgt     2820

gacttccgga gataaaggat tcaaaagata aagacaaagt acgctcagag ttgttaacca     2880

gaaagtcctg gctgtggttg cagaaacact gttggaagaa aagagatgac taagtcaagt     2940

gtctgcctta tcaaaagagc aaaaatgcct ctggttttgt gtttgggaga aaagtatctt     3000

ggacgcactg ttttccttga taaaagtcat cttctctact gtgtgaaatg aatacttgga     3060

attctaattg ttttgtgtgc caggggcagt aatgtccctg cctcttctcc caatcaaggt     3120

tgaggagtgg ggctggggag aggacttaac tgacttaaga agtaggaaaa caaaaacctc     3180

tctcctcagc cttccacctc caagagagga ggaaaaacag ttgtctgctg tctgtaattc     3240

agtttgcgtg tattttatgc tcatgcacca acccatacag agtaaatctt ttatcaactg     3300

tatactggtg tttaatagag aatgattgtc ttccgagttt tttggttcct tttttaactg     3360

tgttaaagta cttgaaatgt attgactgct gactatattt taaaaacaaa atgaaataat     3420

ttgagttgta ttacagaggt tgacattgtt cagggatggg acaaagcctt cttcaatcct     3480

tttcatacta cttaatgatt ttggtgcagg aacctgagat tttctgattt atatttcatg     3540

atatttcaca tttgctcttc acagcatgag catgaagccc agtggcacca aatggctggg     3600

tacaatcaag tgatattttg tagcacctca ctatctgaaa ggccatgagt tttcagatga     3660

tttcattgag cttcattgca gcctgaaatt ttaaaaaagt tgtgtaatac gccaaccagt     3720

caagttgtgt tttggccaga gatttagata tgtccaattt cctggctcat ttcattgtgc     3780

tctatgggta cgtataaaaa gcaagaattc tgtttcctag gcaaacattg caactcaggg     3840

ctaaagtcat ccagtgaaac ttttagagcc agaagtaact ttgtcccagt cctacaatgt     3900

gaaaagagtg aatagttgcc tctttttagc cattttcatg gctggtacat attcgtacgc     3960

attacttttc agaatcaata cgcactttca gatattctta tttttattct cttaagtctt     4020

tattaacttt ggagagagaa atgatgcatc tttttatttt aaatgaagta gatcaacatg     4080

gtggaacaaa atgataaaga acagaaaaca tttcaatata ttactaataa ctttttccaa     4140

tataaatcct aaaattccta taacatagta ttttacagtt ttatgaagct ttctattgtg     4200

acttttatgg aattaagaga tgaagaagat gagatatttt agcatttata tttttcaaaa     4260

ttatatgtat acttaaaaat aaagtaactt tatgca                               4296


<210>  793
<211>  7716
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of SLC4A4

<400>  793
ggcggcgcgc cgggcagcgc ttcggtggcg gcggcggccg cggtggcagc gaaggcggcg       60

gcggcggcgg cagtggcagt ggccgctgca gccccacact ccgccgccaa actggaggag      120

cgacggaagc cagaccccag gaggatggag gatgaagctg tcctggacag aggggcttcc      180

ttcctcaagc atgtgtgtga tgaagaagaa gtagaaggcc accataccat ttacatcgga      240

gtccatgtgc cgaagagtta caggagaagg agacgtcaca agagaaagac agggcacaaa      300

gaaaagaagg aaaaggagag aatctctgag aactactctg acaaatcaga tattgaaaat      360

gctgatgaat ccagcagcag catcctaaaa cctctcatct ctcctgctgc agaacgcatc      420

cgattcatct tgggagagga ggatgacagc ccagctcccc ctcagctctt cacggaactg      480

gatgagctgc tggccgtgga tgggcaggag atggagtgga aggaaacagc caggtggatc      540

aagtttgaag aaaaagtgga acagggtggg gaaagatgga gcaagcccca tgtggccaca      600

ttgtcccttc atagtttatt tgagctgagg acatgtatgg agaaaggatc catcatgctt      660

gatcgggagg cttcttctct cccacagttg gtggagatga ttgttgacca tcagattgag      720

acaggcctat tgaaacctga acttaaggat aaggtgacct atactttgct ccggaagcac      780

cggcatcaaa ccaagaaatc caaccttcgg tccctggctg acattgggaa gacagtctcc      840

agtgcaagta ggatgtttac caaccctgat aatggtagcc cagccatgac ccataggaat      900

ctgacttcct ccagtctgaa tgacatttct gataaaccgg agaaggacca gctgaagaat      960

aagttcatga aaaaattgcc acgtgatgca gaagcttcca acgtgcttgt tggggaggtt     1020

gactttttgg atactccttt cattgccttt gttaggctac agcaggctgt catgctgggt     1080

gccctgactg aagttcctgt gcccacaagg ttcttgttca ttctcttagg tcctaagggg     1140

aaagccaagt cctaccacga gattggcaga gccattgcca ccctgatgtc tgatgaggtg     1200

ttccatgaca ttgcttataa agcaaaagac aggcacgacc tgattgctgg tattgatgag     1260

ttcctagatg aagtcatcgt ccttccacct ggggaatggg atccagcaat taggatagag     1320

cctcctaaga gtcttccatc ctctgacaaa agaaagaata tgtactcagg tggagagaat     1380

gttcagatga atggggatac gccccatgat ggaggtcacg gaggaggagg acatggggat     1440

tgtgaagaat tgcagcgaac tggacggttc tgtggtggac taattaaaga cataaagagg     1500

aaagcgccat tttttgccag tgatttttat gatgctttaa atattcaagc tctttcggca     1560

attctcttca tttatctggc aactgtaact aatgctatca cttttggagg actgcttggg     1620

gatgccactg acaacatgca gggcgtgttg gagagtttcc tgggcactgc tgtctctgga     1680

gccatctttt gcctttttgc tggtcaacca ctcactattc tgagcagcac cggacctgtc     1740

ctagtttttg agaggcttct atttaatttc agcaaggaca ataattttga ctatttggag     1800

tttcgccttt ggattggcct gtggtccgcc ttcctatgtc tcattttggt agccactgat     1860

gccagcttct tggttcaata cttcacacgt ttcacggagg agggcttttc ctctctgatt     1920

agcttcatct ttatctatga tgctttcaag aagatgatca agcttgcaga ttactacccc     1980

atcaactcca acttcaaagt gggctacaac actctctttt cctgtacctg tgtgccacct     2040

gacccagcta atatctcaat atctaatgac accacactgg ccccagagta tttgccaact     2100

atgtcttcta ctgacatgta ccataatact acctttgact gggcattttt gtcgaagaag     2160

gagtgttcaa aatacggagg aaacctcgtc gggaacaact gtaattttgt tcctgatatc     2220

acactcatgt cttttatcct cttcttggga acctacacct cttccatggc tctgaaaaaa     2280

ttcaaaacta gtccttattt tccaaccaca gcaagaaaac tgatcagtga ttttgccatt     2340

atcttgtcca ttctcatctt ttgtgtaata gatgccctag taggcgtgga caccccaaaa     2400

ctaattgtgc caagtgagtt caagccaaca agtccaaacc gaggttggtt cgttccaccg     2460

tttggagaaa acccctggtg ggtgtgcctt gctgctgcta tcccggcttt gttggtcact     2520

atactgattt tcatggacca acaaattaca gctgtgattg taaacaggaa agaacataaa     2580

ctcaagaaag gagcagggta tcacttggat ctcttttggg tggccatcct catggttata     2640

tgctccctca tggctcttcc gtggtatgta gctgctacgg tcatctccat tgctcacatc     2700

gacagtttga agatggagac agagacttct gcacctggag aacaaccaaa gtttctagga     2760

gtgagggaac aaagagtcac tggaaccctt gtgtttattc tgactggtct gtcagtcttt     2820

atggctccca tcttgaagtt tatacccatg cctgtactct atggtgtgtt cctgtatatg     2880

ggagtagcat cccttaatgg tgtgcagttc atggatcgtc tgaagctgct tctgatgcct     2940

ctgaagcatc agcctgactt catctacctg cgtcatgttc ctctgcgcag agtccacctg     3000

ttcactttcc tgcaggtgtt gtgtctggcc ctgctttgga tcctcaagtc aacggtggct     3060

gctatcattt ttccagtaat gatcttggca cttgtagctg tcagaaaagg catggactac     3120

ctcttctccc agcacgacct cagcttcctg gatgatgtca ttccagaaaa ggacaagaaa     3180

aagaaggagg atgagaagaa aaagaaaaag aagaagggaa gtctggacag tgacaatgat     3240

gattctgact gcccatactc agaaaaagtt ccaagtatta aaattccaat ggacatcatg     3300

gaacagcaac ctttcctaag cgatagcaaa ccttctgaca gagaaagatc accaacattc     3360

cttgaacgcc acacatcatg ctgataaaat tcctttcctt cagtcactcg gtatgccaag     3420

tcctcctaga actccagtaa aagttgtgcc tcaaattaga atagaacttg aacctgaaga     3480

caatgattat ttctggagga gcaagggaac agaaactaca ttgtaacctg tttgtctttc     3540

ttaaaactga catttgttgt taatgtcatt tgtttttgtt tggctgtttg tttatttttt     3600

aacttttatt tcgtctcagt ttttggtcac aggccaaata atacagcgct ctctctgctt     3660

ctctcttgca tagacacaat caagacaata gtgcaccgtt ccttaaaaac agcatctgag     3720

gaatccccct tttgttctta aactttcaga tgtgtccttt gataaccaaa ttctgtcact     3780

caagacacag acacgcacag accctgtcct ttgcctctat taagcagagg atggaagtat     3840

taaggatttt gtaacacctt ttatgaaaat gttgaaggaa cttaaaactt tagctttgga     3900

gctgtgctta ctggcttgtc tttgtctggt agaacaaacc ttgacctcca gacagagtcc     3960

cttctcactt atagagctct ccaggactgg aaaaagtgct gctattttaa cttgctcttg     4020

cttgtaaatc ctaatcttag agttatcaaa agaagaaaaa actgaaggta ctttactccc     4080

tatagagaaa ccattgccat cattgtagca agtgctggaa tgtccctttt ttcctatgca     4140

acttttttta accctttaat gaacttatct gttgagtaca ttgaagaata tttttcttcc     4200

tagattttgt tgtttaaatt atggggccta acctgccact tattttttgt caatttttaa     4260

aacttttttt taattactgt aaagaaaatg aattttttcc tgcagcagga aacatagttt     4320

tgagtagttc tacctcttat ttgtagctgc caggctttct gtaaaaattg tattgtatat     4380

aatgtgattt ttacacatac atacacacac aaatacacaa tctctagggt aagccagaag     4440

gcaagatcag attaaaaaca ccatgtttct aagcatccat ttttcccttt ctttaaaaga     4500

aacttaactg ttctatgaag gagattgagg gagaagagac aaactcctat gtcatgagaa     4560

taaccgatgt tctgataata gtagcatcta ggtacagatg ctggttgtat taccacgtca     4620

atgtcctatg cagtattgtt agacattttc tcattttgaa atatttgtgt gtttgtgtat     4680

gtgctctgtg ccatggctgg tgtatatatg tgcaatgtta gaaggcaaaa gagtgatggt     4740

aggcagaggg caaagtcatt gaatctctta tgccagtttt cataaaaccc aaaccacata     4800

tgaaaaaatc cattaagggt ccaagaagtc tgtccatatg aaaatgaggg taaatatagt     4860

ttatttccca ggtatcagtc attataattg atataatagc tctaacatgc aatataaaat     4920

tcataggagt attaatagcc catttacaca tctataaaat gtaatgggat tgcagagctg     4980

cagagtacag tgtaacagta ctctcatgca atttttttca ggatgcaaag gcaattattc     5040

tttgtaagcg ggacatttag aatatatttg tgtacatatt atatgtatgt atatttcaaa     5100

gtaccacact gaaaattaga catttattaa ccaaatttaa cgtggtattt aaaggtaata     5160

tttttaatat gatacattac atattgtgaa tgtatactaa aaaaacattt taaatgttaa     5220

aattataatt tcagattcat ataaccacaa ctgtgatata tcctaactat aaccagttgt     5280

tgaggggtat actagaagca gaatgaaacc acattttttg gtttgataat atgcacttat     5340

tgactcccac tcattgttat gttaattaag ttattattct gtctccttgt aattttgatt     5400

acaaaaattt tattatcctg agttagctgt tacttttaca gtacctgata ctcctaaaac     5460

ttttaactta tacaaattag tcaataatga ccccaatttt ttcattaaaa taatagtggt     5520

gaattatatg ttattgtgtt aaaacctcac ttgccaaatt ctggcttcac atttgtattt     5580

agggctatcc ttaaaatgat gagtctatat tatctagctt tctattaccc taatataaac     5640

tggtataaga agactttcct tttttcttta tgcatggaag catcaataaa ttgtttaaaa     5700

accatgtata gtaaattcag cttaacccgt gatcttctta agttaaaggt acttttgttt     5760

tataaaagct ctagataaaa ctttcttttc tgatcatgaa tcaagtatct gtggtttcat     5820

gcccctctct atacctttca aagaactcct gaagcaactt aactcatcat ttcagcctct     5880

gagtagaggt aaaacctatg tgtacttctg tttatgatcc atattgatat ttatgacatg     5940

aacacagaat agtaccttac atttgctaaa cagacagtta atatcaaatc ctttcaatat     6000

tctgggaacc cagggaagtt tttaaaaatg tcattacttt caaaggaaca gaagtagtta     6060

accaaactaa caagcaaaac ctgaggttta cctagtgaca ccaaattatc ggtattttaa     6120

ctgaatttac ccattgacta agaatgaacc agatttggtg gtggttttgt ttctatgcaa     6180

actggacaca aattacaaca gtaaattttt ttataagtgc ttctcccttc tccatgatgt     6240

gacttccgga gataaaggat tcaaaagata aagacaaagt acgctcagag ttgttaacca     6300

gaaagtcctg gctgtggttg cagaaacact gttggaagaa aagagatgac taagtcaagt     6360

gtctgcctta tcaaaagagc aaaaatgcct ctggttttgt gtttgggaga aaagtatctt     6420

ggacgcactg ttttccttga taaaagtcat cttctctact gtgtgaaatg aatacttgga     6480

attctaattg ttttgtgtgc caggggcagt aatgtccctg cctcttctcc caatcaaggt     6540

tgaggagtgg ggctggggag aggacttaac tgacttaaga agtaggaaaa caaaaacctc     6600

tctcctcagc cttccacctc caagagagga ggaaaaacag ttgtctgctg tctgtaattc     6660

agtttgcgtg tattttatgc tcatgcacca acccatacag agtaaatctt ttatcaactg     6720

tatactggtg tttaatagag aatgattgtc ttccgagttt tttggttcct tttttaactg     6780

tgttaaagta cttgaaatgt attgactgct gactatattt taaaaacaaa atgaaataat     6840

ttgagttgta ttacagaggt tgacattgtt cagggatggg acaaagcctt cttcaatcct     6900

tttcatacta cttaatgatt ttggtgcagg aacctgagat tttctgattt atatttcatg     6960

atatttcaca tttgctcttc acagcatgag catgaagccc agtggcacca aatggctggg     7020

tacaatcaag tgatattttg tagcacctca ctatctgaaa ggccatgagt tttcagatga     7080

tttcattgag cttcattgca gcctgaaatt ttaaaaaagt tgtgtaatac gccaaccagt     7140

caagttgtgt tttggccaga gatttagata tgtccaattt cctggctcat ttcattgtgc     7200

tctatgggta cgtataaaaa gcaagaattc tgtttcctag gcaaacattg caactcaggg     7260

ctaaagtcat ccagtgaaac ttttagagcc agaagtaact ttgtcccagt cctacaatgt     7320

gaaaagagtg aatagttgcc tctttttagc cattttcatg gctggtacat attcgtacgc     7380

attacttttc agaatcaata cgcactttca gatattctta tttttattct cttaagtctt     7440

tattaacttt ggagagagaa atgatgcatc tttttatttt aaatgaagta gatcaacatg     7500

gtggaacaaa atgataaaga acagaaaaca tttcaatata ttactaataa ctttttccaa     7560

tataaatcct aaaattccta taacatagta ttttacagtt ttatgaagct ttctattgtg     7620

acttttatgg aattaagaga tgaagaagat gagatatttt agcatttata tttttcaaaa     7680

ttatatgtat acttaaaaat aaagtaactt tatgca                               7716


<210>  794
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  794

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu 
            20                  


<210>  795
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  795

His His Thr Ile Tyr Ile Gly Val His Val Pro Lys Ser Tyr Arg Arg 
1               5                   10                  15      


Arg Arg Arg His Lys Arg Lys Thr Gly His Lys Glu Lys Lys Glu Lys 
            20                  25                  30          


Glu Arg Ile Ser Glu Asn Tyr Ser Asp Lys Ser Asp Ile Glu Asn Ala 
        35                  40                  45              


Asp Glu Ser Ser Ser Ser Ile Leu Lys Pro Leu 
    50                  55                  


<210>  796
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  796

Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu Gly Glu Glu Asp Asp 
1               5                   10                  15      


Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu Asp Glu Leu Leu Ala 
            20                  25                  30          


Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr Ala 
        35                  40                  


<210>  797
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  797

Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg Trp Ser 
1               5                   10                  15      


Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu Leu Arg 
            20                  25                  30          


Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala Ser Ser 
        35                  40                  45              


Leu Pro Gln Leu Val 
    50              


<210>  798
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  798

Met Ile Val Asp His Gln Ile Glu Thr Gly Leu Leu Lys Pro Glu Leu 
1               5                   10                  15      


Lys Asp Lys Val Thr Tyr Thr Leu Leu Arg Lys His Arg His Gln Thr 
            20                  25                  30          


Lys Lys Ser Asn Leu Arg Ser Leu Ala Asp Ile Gly Lys Thr Val Ser 
        35                  40                  45              


Ser Ala Ser Arg Met Phe Thr Asn Pro Asp Asn 
    50                  55                  


<210>  799
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  799

Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser Ser Leu Asn Asp 
1               5                   10                  15      


Ile Ser Asp Lys Pro Glu Lys Asp Gln 
            20                  25  


<210>  800
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  800

Leu Lys Asn Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser 
1               5                   10                  15      


Asn Val Leu Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala 
            20                  25                  30          


Phe Val Arg Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val 
        35                  40                  45              


Pro Val Pro Thr 
    50          


<210>  801
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  801

Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser Tyr His 
1               5                   10                  15      


Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu 
            20                  25                  


<210>  802
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  802

Val Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile 
1               5                   10                  15      


Ala Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly 
            20                  25                  30          


Glu Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser 
        35                  40                  45              


Ser Asp Lys 
    50      


<210>  803
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  803

Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn Gly Asp Thr 
1               5                   10                  15      


Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp Cys Glu Glu 
            20                  25                  30          


Leu Gln Arg Thr Gly 
        35          


<210>  804
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  804

Phe Cys Gly Gly Leu Ile Lys Asp Ile Lys Arg Lys Ala Pro Phe Phe 
1               5                   10                  15      


Ala Ser Asp Phe Tyr Asp Ala Leu Asn Ile Gln Ala Leu Ser Ala Ile 
            20                  25                  30          


Leu Phe Ile Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly 
        35                  40                  45              


Leu Leu Gly Asp Ala Thr Asp Asn Met Gln 
    50                  55              


<210>  805
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  805

Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly Ala Ile Phe 
1               5                   10                  15      


Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser Thr Gly Pro 
            20                  25                  30          


Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser 
        35                  40                  


<210>  806
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  806

Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
1               5                   10                  15      


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
            20                  25                  30          


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
        35                  40                  45              


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
    50                  55                  60                  


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
65                  70                  75                  80  


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro 
                85                  90  


<210>  807
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  807

Asn Ile Ser Ile Ser Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro 
1               5                   10                  15      


Thr Met Ser Ser Thr Asp Met 
            20              


<210>  808
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  808

Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys Glu Cys 
1               5                   10                  15      


Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe Val Pro 
            20                  25                  30          


Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr Thr Ser 
        35                  40                  45              


Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro Thr Thr 
    50                  55                  60                  


<210>  809
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  809

Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile Leu Ile 
1               5                   10                  15      


Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys Leu Ile 
            20                  25                  30          


Val Pro Ser Glu Phe Lys 
        35              


<210>  810
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  810

Pro Thr Ser Pro Asn Arg Gly Trp Phe Val Pro Pro Phe Gly Glu Asn 
1               5                   10                  15      


Pro Trp Trp Val Cys Leu Ala Ala Ala Ile Pro Ala Leu Leu Val Thr 
            20                  25                  30          


Ile Leu Ile Phe Met Asp Gln Gln Ile Thr Ala Val Ile Val Asn Arg 
        35                  40                  45              


Lys Glu His Lys Leu Lys 
    50                  


<210>  811
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  811

Lys Gly Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met 
1               5                   10                  15      


Val Ile Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val 
            20                  25                  30          


Ile Ser Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser 
        35                  40                  45              


Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Val 
    50                  55                  


<210>  812
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  812

Glu Gln Arg Val Thr Gly Thr Leu Val Phe Ile Leu Thr Gly Leu Ser 
1               5                   10                  15      


Val Phe Met Ala Pro Ile Leu Lys 
            20                  


<210>  813
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  813

Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met Gly Val 
1               5                   10                  15      


Ala Ser Leu Asn Gly Val Gln 
            20              


<210>  814
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  814

Phe Met Asp Arg Leu Lys Leu Leu Leu Met Pro Leu Lys His Gln Pro 
1               5                   10                  15      


Asp Phe Ile Tyr Leu Arg His Val Pro Leu Arg Arg Val His Leu Phe 
            20                  25                  30          


Thr Phe Leu Gln Val Leu Cys Leu Ala Leu Leu Trp Ile Leu Lys Ser 
        35                  40                  45              


Thr Val Ala Ala Ile Ile Phe Pro Val Met 
    50                  55              


<210>  815
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  815

Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr Leu Phe Ser 
1               5                   10                  15      


Gln His Asp Leu Ser Phe Leu Asp Asp Val Ile Pro Glu Lys Asp Lys 
            20                  25                  30          


Lys Lys Lys Glu Asp Glu Lys Lys Lys Lys Lys Lys Lys Gly Ser Leu 
        35                  40                  45              


Asp Ser Asp Asn Asp Asp 
    50                  


<210>  816
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  816

Ser Asp Cys Pro Tyr Ser Glu Lys Val Pro Ser Ile Lys Ile Pro Met 
1               5                   10                  15      


Asp Ile Met Glu Gln Gln Pro Phe Leu Ser Asp Ser Lys Pro Ser Asp 
            20                  25                  30          


<210>  817
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  817

Glu Arg Ser Pro Thr Phe Leu Glu Arg His Thr Ser Cys 
1               5                   10              


<210>  818
<211>  0
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intentionally skipped sequence

<400>  818
000

<210>  819
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  819

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
            20                  25                  30          


Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
        35                  40                  45              


Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                85                  90                  95      


Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
            100                 105                 110         


Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
        115                 120                 125             


Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
    130                 135                 140                 


Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
145                 150                 155                 160 


Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                165                 170                 175     


Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
            180                 185                 190         


Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
        195                 200                 205             


Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
225                 230                 235                 240 


Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                245                 250                 255     


Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
            260                 265                 270         


Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
        275                 280                 285             


Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
    290                 295                 300                 


Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
305                 310                 315                 320 


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                325                 330                 335     


Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
            340                 345                 350         


Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
        355                 360                 365             


Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
    370                 375                 380                 


Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
385                 390                 395                 400 


Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                405                 410                 415     


Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
            420                 425                 430         


Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
        435                 440                 445             


Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
    450                 455                 460                 


Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                485                 490                 495     


Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
            500                 505                 510         


Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
        515                 520                 525             


Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
    530                 535                 540                 


Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
545                 550                 555                 560 


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                565                 570                 575     


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
            580                 585                 590         


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
        595                 600                 605             


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
    610                 615                 620                 


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro Ala Asn Ile Ser Ile Ser 
625                 630                 635                 640 


Asn Asp Thr Thr Leu Ala Pro Glu Tyr Leu Pro Thr Met Ser Ser Thr 
                645                 650                 655     


Asp Met Tyr His Asn Thr Thr Phe Asp Trp Ala Phe Leu Ser Lys Lys 
            660                 665                 670         


Glu Cys Ser Lys Tyr Gly Gly Asn Leu Val Gly Asn Asn Cys Asn Phe 
        675                 680                 685             


Val Pro Asp Ile Thr Leu Met Ser Phe Ile Leu Phe Leu Gly Thr Tyr 
    690                 695                 700                 


Thr Ser Ser Met Ala Leu Lys Lys Phe Lys Thr Ser Pro Tyr Phe Pro 
705                 710                 715                 720 


Thr Thr Ala Arg Lys Leu Ile Ser Asp Phe Ala Ile Ile Leu Ser Ile 
                725                 730                 735     


Leu Ile Phe Cys Val Ile Asp Ala Leu Val Gly Val Asp Thr Pro Lys 
            740                 745                 750         


Leu Ile Val Pro Ser Glu Phe Lys Pro Thr Ser Pro Asn Arg Gly Trp 
        755                 760                 765             


Phe Val Pro Pro Phe Gly Glu Asn Pro Trp Trp Val Cys Leu Ala Ala 
    770                 775                 780                 


Ala Ile Pro Ala Leu Leu Val Thr Ile Leu Ile Phe Met Asp Gln Gln 
785                 790                 795                 800 


Ile Thr Ala Val Ile Val Asn Arg Lys Glu His Lys Leu Lys Lys Gly 
                805                 810                 815     


Ala Gly Tyr His Leu Asp Leu Phe Trp Val Ala Ile Leu Met Val Ile 
            820                 825                 830         


Cys Ser Leu Met Ala Leu Pro Trp Tyr Val Ala Ala Thr Val Ile Ser 
        835                 840                 845             


Ile Ala His Ile Asp Ser Leu Lys Met Glu Thr Glu Thr Ser Ala Pro 
    850                 855                 860                 


Gly Glu Gln Pro Lys Phe Leu Gly Val Arg Glu Gln Arg Val Thr Gly 
865                 870                 875                 880 


Thr Leu Val Phe Ile Leu Thr Gly Leu Ser Val Phe Met Ala Pro Ile 
                885                 890                 895     


Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe Leu Tyr Met 
            900                 905                 910         


Gly Val Ala Ser Leu Asn Gly Val Gln Phe Met Asp Arg Leu Lys Leu 
        915                 920                 925             


Leu Leu Met Pro Leu Lys His Gln Pro Asp Phe Ile Tyr Leu Arg His 
    930                 935                 940                 


Val Pro Leu Arg Arg Val His Leu Phe Thr Phe Leu Gln Val Leu Cys 
945                 950                 955                 960 


Leu Ala Leu Leu Trp Ile Leu Lys Ser Thr Val Ala Ala Ile Ile Phe 
                965                 970                 975     


Pro Val Met Ile Leu Ala Leu Val Ala Val Arg Lys Gly Met Asp Tyr 
            980                 985                 990         


Leu Phe Ser Gln His Asp Leu Ser  Phe Leu Asp Asp Val  Ile Pro Glu 
        995                 1000                 1005             


Lys Asp  Lys Lys Lys Lys Glu  Asp Glu Lys Lys Lys  Lys Lys Lys 
    1010                 1015                 1020             


Lys Gly  Ser Leu Asp Ser Asp  Asn Asp Asp Ser Asp  Cys Pro Tyr 
    1025                 1030                 1035             


Ser Glu  Lys Val Pro Ser Ile  Lys Ile Pro Met Asp  Ile Met Glu 
    1040                 1045                 1050             


Gln Gln  Pro Phe Leu Ser Asp  Ser Lys Pro Ser Asp  Arg Glu Arg 
    1055                 1060                 1065             


Ser Pro  Thr Phe Leu Glu Arg  His Thr Ser Cys 
    1070                 1075                 


<210>  820
<211>  2047
<212>  DNA
<213>  Homo sapiens

<400>  820
ggcggcgcgc cgggcagcgc ttcggtggcg gcggcggccg cggtggcagc gaaggcggcg       60

gcggcggcgg cagtggcagt ggccgctgca gccccacact ccgccgccaa actggaggag      120

cgacggaagc cagaccccag gaggatggag gatgaagctg tcctggacag aggggcttcc      180

ttcctcaagc atgtgtgtga tgaagaagaa gtagaaggcc accataccat ttacatcgga      240

gtccatgtgc cgaagagtta caggagaagg agacgtcaca agagaaagac agggcacaaa      300

gaaaagaagg aaaaggagag aatctctgag aactactctg acaaatcaga tattgaaaat      360

gctgatgaat ccagcagcag catcctaaaa cctctcatct ctcctgctgc agaacgcatc      420

cgattcatct tgggagagga ggatgacagc ccagctcccc ctcagctctt cacggaactg      480

gatgagctgc tggccgtgga tgggcaggag atggagtgga aggaaacagc caggtggatc      540

aagtttgaag aaaaagtgga acagggtggg gaaagatgga gcaagcccca tgtggccaca      600

ttgtcccttc atagtttatt tgagctgagg acatgtatgg agaaaggatc catcatgctt      660

gatcgggagg cttcttctct cccacagttg gtggagatga ttgttgacca tcagattgag      720

acaggcctat tgaaacctga acttaaggat aaggtgacct atactttgct ccggaagcac      780

cggcatcaaa ccaagaaatc caaccttcgg tccctggctg acattgggaa gacagtctcc      840

agtgcaagta ggatgtttac caaccctgat aatggtagcc cagccatgac ccataggaat      900

ctgacttcct ccagtctgaa tgacatttct gataaaccgg agaaggacca gctgaagaat      960

aagttcatga aaaaattgcc acgtgatgca gaagcttcca acgtgcttgt tggggaggtt     1020

gactttttgg atactccttt cattgccttt gttaggctac agcaggctgt catgctgggt     1080

gccctgactg aagttcctgt gcccacaagg ttcttgttca ttctcttagg tcctaagggg     1140

aaagccaagt cctaccacga gattggcaga gccattgcca ccctgatgtc tgatgaggtg     1200

ttccatgaca ttgcttataa agcaaaagac aggcacgacc tgattgctgg tattgatgag     1260

ttcctagatg aagtcatcgt ccttccacct ggggaatggg atccagcaat taggatagag     1320

cctcctaaga gtcttccatc ctctgacaaa agaaagaata tgtactcagg tggagagaat     1380

gttcagatga atggggatac gccccatgat ggaggtcacg gaggaggagg acatggggat     1440

tgtgaagaat tgcagcgaac tggacggttc tgtggtggac taattaaaga cataaagagg     1500

aaagcgccat tttttgccag tgatttttat gatgctttaa atattcaagc tctttcggca     1560

attctcttca tttatctggc aactgtaact aatgctatca cttttggagg actgcttggg     1620

gatgccactg acaacatgca gggcgtgttg gagagtttcc tgggcactgc tgtctctgga     1680

gccatctttt gcctttttgc tggtcaacca ctcactattc tgagcagcac cggacctgtc     1740

ctagtttttg agaggcttct atttaatttc agcaaggaca ataattttga ctatttggag     1800

tttcgccttt ggattggcct gtggtccgcc ttcctatgtc tcattttggt agccactgat     1860

gccagcttct tggttcaata cttcacacgt ttcacggagg agggcttttc ctctctgatt     1920

agcttcatct ttatctatga tgctttcaag aagatgatca agcttgcaga ttactacccc     1980

atcaactcca acttcaaagt gggctacaac actctctttt cctgtacctg tgtgccacct     2040

gacccag                                                               2047


<210>  821
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  821

Met Glu Asp Glu Ala Val Leu Asp Arg Gly Ala Ser Phe Leu Lys His 
1               5                   10                  15      


Val Cys Asp Glu Glu Glu Val Glu Gly His His Thr Ile Tyr Ile Gly 
            20                  25                  30          


Val His Val Pro Lys Ser Tyr Arg Arg Arg Arg Arg His Lys Arg Lys 
        35                  40                  45              


Thr Gly His Lys Glu Lys Lys Glu Lys Glu Arg Ile Ser Glu Asn Tyr 
    50                  55                  60                  


Ser Asp Lys Ser Asp Ile Glu Asn Ala Asp Glu Ser Ser Ser Ser Ile 
65                  70                  75                  80  


Leu Lys Pro Leu Ile Ser Pro Ala Ala Glu Arg Ile Arg Phe Ile Leu 
                85                  90                  95      


Gly Glu Glu Asp Asp Ser Pro Ala Pro Pro Gln Leu Phe Thr Glu Leu 
            100                 105                 110         


Asp Glu Leu Leu Ala Val Asp Gly Gln Glu Met Glu Trp Lys Glu Thr 
        115                 120                 125             


Ala Arg Trp Ile Lys Phe Glu Glu Lys Val Glu Gln Gly Gly Glu Arg 
    130                 135                 140                 


Trp Ser Lys Pro His Val Ala Thr Leu Ser Leu His Ser Leu Phe Glu 
145                 150                 155                 160 


Leu Arg Thr Cys Met Glu Lys Gly Ser Ile Met Leu Asp Arg Glu Ala 
                165                 170                 175     


Ser Ser Leu Pro Gln Leu Val Glu Met Ile Val Asp His Gln Ile Glu 
            180                 185                 190         


Thr Gly Leu Leu Lys Pro Glu Leu Lys Asp Lys Val Thr Tyr Thr Leu 
        195                 200                 205             


Leu Arg Lys His Arg His Gln Thr Lys Lys Ser Asn Leu Arg Ser Leu 
    210                 215                 220                 


Ala Asp Ile Gly Lys Thr Val Ser Ser Ala Ser Arg Met Phe Thr Asn 
225                 230                 235                 240 


Pro Asp Asn Gly Ser Pro Ala Met Thr His Arg Asn Leu Thr Ser Ser 
                245                 250                 255     


Ser Leu Asn Asp Ile Ser Asp Lys Pro Glu Lys Asp Gln Leu Lys Asn 
            260                 265                 270         


Lys Phe Met Lys Lys Leu Pro Arg Asp Ala Glu Ala Ser Asn Val Leu 
        275                 280                 285             


Val Gly Glu Val Asp Phe Leu Asp Thr Pro Phe Ile Ala Phe Val Arg 
    290                 295                 300                 


Leu Gln Gln Ala Val Met Leu Gly Ala Leu Thr Glu Val Pro Val Pro 
305                 310                 315                 320 


Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Lys Gly Lys Ala Lys Ser 
                325                 330                 335     


Tyr His Glu Ile Gly Arg Ala Ile Ala Thr Leu Met Ser Asp Glu Val 
            340                 345                 350         


Phe His Asp Ile Ala Tyr Lys Ala Lys Asp Arg His Asp Leu Ile Ala 
        355                 360                 365             


Gly Ile Asp Glu Phe Leu Asp Glu Val Ile Val Leu Pro Pro Gly Glu 
    370                 375                 380                 


Trp Asp Pro Ala Ile Arg Ile Glu Pro Pro Lys Ser Leu Pro Ser Ser 
385                 390                 395                 400 


Asp Lys Arg Lys Asn Met Tyr Ser Gly Gly Glu Asn Val Gln Met Asn 
                405                 410                 415     


Gly Asp Thr Pro His Asp Gly Gly His Gly Gly Gly Gly His Gly Asp 
            420                 425                 430         


Cys Glu Glu Leu Gln Arg Thr Gly Arg Phe Cys Gly Gly Leu Ile Lys 
        435                 440                 445             


Asp Ile Lys Arg Lys Ala Pro Phe Phe Ala Ser Asp Phe Tyr Asp Ala 
    450                 455                 460                 


Leu Asn Ile Gln Ala Leu Ser Ala Ile Leu Phe Ile Tyr Leu Ala Thr 
465                 470                 475                 480 


Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp 
                485                 490                 495     


Asn Met Gln Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ser Gly 
            500                 505                 510         


Ala Ile Phe Cys Leu Phe Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser 
        515                 520                 525             


Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe Asn Phe Ser Lys 
    530                 535                 540                 


Asp Asn Asn Phe Asp Tyr Leu Glu Phe Arg Leu Trp Ile Gly Leu Trp 
545                 550                 555                 560 


Ser Ala Phe Leu Cys Leu Ile Leu Val Ala Thr Asp Ala Ser Phe Leu 
                565                 570                 575     


Val Gln Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe Ser Ser Leu Ile 
            580                 585                 590         


Ser Phe Ile Phe Ile Tyr Asp Ala Phe Lys Lys Met Ile Lys Leu Ala 
        595                 600                 605             


Asp Tyr Tyr Pro Ile Asn Ser Asn Phe Lys Val Gly Tyr Asn Thr Leu 
    610                 615                 620                 


Phe Ser Cys Thr Cys Val Pro Pro Asp Pro 
625                 630                 


<210>  822
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  822
atgtgtccaa caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa       60

cggaggtcct ggcag                                                        75


<210>  823
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  823
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaa                                                        75


<210>  824
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  824
atgtgtccaa caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa       60

cggaggtcct ggcagccttg cctccccgat tgaaagagat gaaaagccag gaatcggctg      120

caggttccaa actagtcctt cggtgtgaaa                                       150


<210>  825
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  825

Val Ser Asn Lys Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile 
1               5                   10                  15      


Phe Glu Arg Thr Glu Val Leu Ala Ala Leu Pro Pro Arg Leu Lys Glu 
            20                  25                  30          


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
        35                  40                  45              


Glu 
    


<210>  826
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  826
acaggaagca ccctaatgag gagtatgcca acgtgggcac cggggagctg gcagcggagg       60

tgctcatcca gcaag                                                        75


<210>  827
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  827
ctacatctac atccaccact gggacaagcc atcttgtaaa atgtgcggag aaggagaaaa       60

ctttctgtgt gaatg                                                        75


<210>  828
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  828
acaggaagca ccctaatgag gagtatgcca acgtgggcac cggggagctg gcagcggagg       60

tgctcatcca gcaagctaca tctacatcca ccactgggac aagccatctt gtaaaatgtg      120

cggagaagga gaaaactttc tgtgtgaatg                                       150


<210>  829
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  829

Arg Lys His Pro Asn Glu Glu Tyr Ala Asn Val Gly Thr Gly Glu Leu 
1               5                   10                  15      


Ala Ala Glu Val Leu Ile Gln Gln Ala Thr Ser Thr Ser Thr Thr Gly 
            20                  25                  30          


Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val 
        35                  40                  45              


Asn 
    


<210>  830
<211>  187
<212>  DNA
<213>  Homo sapiens

<400>  830
atccgccatg ttggatgccg cagattcgcc ataacctcgc cggctctttt cttaaaaaaa       60

taaaaataaa aagcgaagcg tcagcagggc gccccgcccc ctcggtcggc acgggagggg      120

gcccggaaga gcccgaggct tttttttcct ccgcggtggg gcgttgccat ggagacgcgg      180

gcggcag                                                                187


<210>  831
<211>  177
<212>  DNA
<213>  Homo sapiens

<400>  831
aaaacacggc catctttatg tgtaaatgtt gtaacctctt ctcaccaaat cagtcggaac       60

tcctctccca cgtttcagag aagcacatgg aagaaggggt taatgttgat gagattatta      120

ttccccttag gcctctgagt acacctgaac cccccaactc aagcaaaacc ggagatg         177


<210>  832
<211>  252
<212>  DNA
<213>  Homo sapiens

<400>  832
agtttttggt catgaagagg aagagaggca ggcctaaggg gtccacgaag aagtccagca       60

cagaagagga gctggcagaa aacatcgtga gtccgactga ggacagcccg ctggctccgg      120

aggaagggaa cagcctgcct ccaagcagct tggagtgtag caagtgctgt cggaagttct      180

ccaacacgcg ccagctgcgg aagcacatct gcattatcgt gctgaatttg ggtgaggagg      240

aaggagaagc ag                                                          252


<210>  833
<211>  186
<212>  DNA
<213>  Homo sapiens

<400>  833
gtaacgagtc tgaccttgaa ctagaaaaga agtgtaagga agatgatcgg gaaaaagcct       60

cgaaaagacc acggtcacag aaaacagaga aagtccagaa gatctcagga aaggaggcca      120

gacagctttc tggggcgaag aaacccatca taagtgtggt tttaactgca cacgaagcaa      180

ttccag                                                                 186


<210>  834
<211>  151
<212>  DNA
<213>  Homo sapiens

<400>  834
gtgctaccaa gattgtgcca gtggaggctg ggccccctga aacaggagct acaaattctg       60

agaccacttc agcagacctg gtgcctcgga gaggctacca ggaatacgcc attcagcaga      120

caccttatga gcaaccaatg aagtcaagca g                                     151


<210>  835
<211>  1457
<212>  DNA
<213>  Homo sapiens

<400>  835
gctaggtccc actcagctca aaatcttcac ttgtgaatac tgcaacaagg tcttcaagtt       60

caagcactcg ctgcaggccc acctgaggat ccacaccaat gaaaagccat acaagtgccc      120

ccagtgcagc tatgccagtg ccatcaaggc caacctcaat gtgcacctgc gcaagcacac      180

tggagagaag ttcgcctgcg actattgctc gttcacctgc ctgagcaagg gccacctcaa      240

ggtgcacatc gagcgagtgc acaagaagat caagcagcac tgccgcttct gcaagaagaa      300

gtactctgac gtcaagaacc tcatcaagca catccgagac gcgcatgacc cacaggacaa      360

gaaggtcaaa gaggccttgg acgagctctg cctgatgacg agggagggca agcggcagct      420

gctctatgac tgccacatct gtgagcgcaa gttcaagaac gagctggacc gtgaccgcca      480

tatgctggtc cacggagaca agtggccttt tgcctgtgag ctctgtggcc atggggccac      540

caagtaccag gcgctggaac tgcatgtcag gaagcacccc ttcgtgtacg tctgtgccgt      600

ctgccgcaag aagttcgtca gctccatcag gctgcgcacc cacatcaaag aggtgcacgg      660

ggctgcccag gaggccttgg tcttcaccag ttccatcaac cagagcttct gcctcctgga      720

acctggtggg gacatccagc aagaagctct gggggaccag ctacagctgg tggaagagga      780

gtttgccctc cagggcgtga atgcactcaa ggaagaggcc tgtcctgggg acactcagct      840

ggaggagggc cggaaggagc cggaggcccc tggggaaatg cctgccccag ctgtgcacct      900

ggcctccccg caggccgaaa gcacagccct gccaccctgt gagctggaaa ccaccgtggt      960

ctcctcctca gacctgcatt ctcaagaggt ggtttcagat gattttttgt tgaaaaatga     1020

tacctcctcc gcagaggctc atgctgctcc tgagaagccc ccagacatgc agcacagaag     1080

ctcagtccag acgcaaggtg aagtgatcac actactgctg tccaaggccc agagtgctgg     1140

gtcagatcag gaaagccatg gcgcccagag ccccctaggg gaagggcaga acatggctgt     1200

gctttcagct ggtgacccag atcccagcag gtgtctcagg tcaaacccag ctgaggcctc     1260

agacctcctc cctccagtag ctggtggtgg ggacaccatc acacatcagc ctgactcttg     1320

caaagctgcc cctgagcacc ggtcaggcat caccgctttc atgaaggtcc tgaacagttt     1380

acagaagaag caaatgaaca ccagcttgtg tgagcggatc cggaaggttt atggagacct     1440

ggagtgtgaa tactgtg                                                    1457


<210>  836
<211>  233
<212>  DNA
<213>  Homo sapiens

<400>  836
gcaaactttt ttggtaccaa gtgcattttg atatgcatgt ccgcacccac acccgggaac       60

atctgtatta ttgctctcag tgtcattatt cttccatcac caaaaactgc cttaaacgcc      120

acgtaattca gaaacacagt aacatcttgc tgaagtgtcc caccgatggc tgtgactact      180

caactccaga taaatataag ctacaggcac atcttaaagt tcacacagca ctg             233


<210>  837
<211>  88
<212>  DNA
<213>  Homo sapiens

<400>  837
gacaaaagga gttattcttg tcctgtttgt gaaaagtctt tttcagagga tcgattgata       60

aagtcacata tcaagaccaa ccatcctg                                          88


<210>  838
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  838
aggtctccat gagcaccatt tctgaggttc tcgggaggag ggttcagctg aaagggctaa       60

ttggaaagag agccatgaaa tgcccatatt gtgactttta tttcatgaag aatggctcag      120

accttcagcg tcatatttgg gctcatgaag                                       150


<210>  839
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  839
gtgtgaagcc cttcaagtgt tctttgtgtg agtatgcaac tcgtagcaag agtaacctca       60

aggctcatat gaatcgtcac agcactgaga aaacccacct atgtgacatg tgtggcaaga      120

aattcaaatc aaaagggaca ctgaaaagtc acaaactcct tcacactgca gatg            174


<210>  840
<211>  89
<212>  DNA
<213>  Homo sapiens

<400>  840
ggaagcagtt taagtgcacg gtgtgtgact acacagcggc ccagaagcca cagctgctgc       60

ggcacatgga acagcatgtc tccttcaag                                         89


<210>  841
<211>  139
<212>  DNA
<213>  Homo sapiens

<400>  841
cctttccgct gtgcccattg ccattactcc tgcaacatat ctggctctct gaagcggcac       60

tacaacagga agcaccctaa tgaggagtat gccaacgtgg gcaccgggga gctggcagcg      120

gaggtgctca tccagcaag                                                   139


<210>  842
<211>  119
<212>  DNA
<213>  Homo sapiens

<400>  842
gtggtttgaa gtgtcctgtt tgcagctttg tatatggcac caaatgggag ttcaataggc       60

acttgaagaa caaacatggc ttgaaggtgg tggaaattga tggagacccc aagtgggag       119


<210>  843
<211>  127
<212>  DNA
<213>  Homo sapiens

<400>  843
acagcaacag aagctcctga ggagccctcc acccagtatc tccacatcac agaggccgaa       60

gaagacgttc aagggacaca ggcagcggtg gccgcgctcc aggacctgag atacacctct      120

gagagtg                                                                127


<210>  844
<211>  131
<212>  DNA
<213>  Homo sapiens

<400>  844
gcgaccgact ggaccccacg gccgtgaaca tcctgcagca gatcattgag ctgggcgccg       60

agacccatga cgccactgcc cttgcctcgg tggttgccat ggcaccaggg acggtgactg      120

tggttaagca g                                                           131


<210>  845
<211>  934
<212>  DNA
<213>  Homo sapiens

<400>  845
gtcaccgagg aggagcccag ctccaaccac acggtcatga tccaggagac ggtccagcaa       60

gcgtccgtgg agcttgccga gcagcaccac ctggtggtgt cctccgacga cgtggagggc      120

attgagacgg tgactgtcta cacgcagggc ggggaggcct cggagttcat cgtctacgtg      180

caggaggcca tgcagcctgt ggaggagcag gctgtggagc agccggccca ggaactctag      240

aggacatgtg gcatcggatg gccacagggc ggggctgcca ggctctgcag gcacccaggg      300

tggggaggcc acccttcctg ccctacccgc agaatggtgc tctcctttgc cctccctgcc      360

cagcagcctg ataggactct cctagtccaa cttggggtgg gcaaggcagt cagcatcacc      420

agcaatacca caggaccctc accccagcat agacacacac cccctgaccc ttaccatctg      480

cttcctgaaa gacttcagtg tcagctcccc tacacacacc ccacaccttc accccttgct      540

tcaagattca aacagagact cccagtcccc ctcagcatct tccctgaatc acagccccag      600

ctccttgacc cccatctagg tgccaaatgt tcatctgcaa ccgctatgca gtctggtgag      660

agggagacag ccatcacata gaaagtgacc gtacgggttt ttaatcactg ctgggtgggg      720

tgggggtagg gggattgtcc tggctttgtc gacaaagtcc cacttccccg agtattaagg      780

gcccttggta tcaagtgagg taaattcacc catcacaggg tctcgcccta ccatcctgga      840

attatttcac ttttaagata aatgcactat ttcactgttc gcctcccatt ctaaggaggt      900

gaggtggttg gaataaaaac agttcctgtc tgaa                                  934


<210>  846
<211>  4594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of ZFAT

<400>  846
atccgccatg ttggatgccg cagattcgcc ataacctcgc cggctctttt cttaaaaaaa       60

taaaaataaa aagcgaagcg tcagcagggc gccccgcccc ctcggtcggc acgggagggg      120

gcccggaaga gcccgaggct tttttttcct ccgcggtggg gcgttgccat ggagacgcgg      180

gcggcagaaa acacggccat ctttatgtgt aaatgttgta acctcttctc accaaatcag      240

tcggaactcc tctcccacgt ttcagagaag cacatggaag aaggggttaa tgttgatgag      300

attattattc cccttaggcc tctgagtaca cctgaacccc ccaactcaag caaaaccgga      360

gatgagtttt tggtcatgaa gaggaagaga ggcaggccta aggggtccac gaagaagtcc      420

agcacagaag aggagctggc agaaaacatc gtgagtccga ctgaggacag cccgctggct      480

ccggaggaag ggaacagcct gcctccaagc agcttggagt gtagcaagtg ctgtcggaag      540

ttctccaaca cgcgccagct gcggaagcac atctgcatta tcgtgctgaa tttgggtgag      600

gaggaaggag aagcaggtaa cgagtctgac cttgaactag aaaagaagtg taaggaagat      660

gatcgggaaa aagcctcgaa aagaccacgg tcacagaaaa cagagaaagt ccagaagatc      720

tcaggaaagg aggccagaca gctttctggg gcgaagaaac ccatcataag tgtggtttta      780

actgcacacg aagcaattcc aggtgctacc aagattgtgc cagtggaggc tgggccccct      840

gaaacaggag ctacaaattc tgagaccact tcagcagacc tggtgcctcg gagaggctac      900

caggaatacg ccattcagca gacaccttat gagcaaccaa tgaagtcaag caggctaggt      960

cccactcagc tcaaaatctt cacttgtgaa tactgcaaca aggtcttcaa gttcaagcac     1020

tcgctgcagg cccacctgag gatccacacc aatgaaaagc catacaagtg cccccagtgc     1080

agctatgcca gtgccatcaa ggccaacctc aatgtgcacc tgcgcaagca cactggagag     1140

aagttcgcct gcgactattg ctcgttcacc tgcctgagca agggccacct caaggtgcac     1200

atcgagcgag tgcacaagaa gatcaagcag cactgccgct tctgcaagaa gaagtactct     1260

gacgtcaaga acctcatcaa gcacatccga gacgcgcatg acccacagga caagaaggtc     1320

aaagaggcct tggacgagct ctgcctgatg acgagggagg gcaagcggca gctgctctat     1380

gactgccaca tctgtgagcg caagttcaag aacgagctgg accgtgaccg ccatatgctg     1440

gtccacggag acaagtggcc ttttgcctgt gagctctgtg gccatggggc caccaagtac     1500

caggcgctgg aactgcatgt caggaagcac cccttcgtgt acgtctgtgc cgtctgccgc     1560

aagaagttcg tcagctccat caggctgcgc acccacatca aagaggtgca cggggctgcc     1620

caggaggcct tggtcttcac cagttccatc aaccagagct tctgcctcct ggaacctggt     1680

ggggacatcc agcaagaagc tctgggggac cagctacagc tggtggaaga ggagtttgcc     1740

ctccagggcg tgaatgcact caaggaagag gcctgtcctg gggacactca gctggaggag     1800

ggccggaagg agccggaggc ccctggggaa atgcctgccc cagctgtgca cctggcctcc     1860

ccgcaggccg aaagcacagc cctgccaccc tgtgagctgg aaaccaccgt ggtctcctcc     1920

tcagacctgc attctcaaga ggtggtttca gatgattttt tgttgaaaaa tgatacctcc     1980

tccgcagagg ctcatgctgc tcctgagaag cccccagaca tgcagcacag aagctcagtc     2040

cagacgcaag gtgaagtgat cacactactg ctgtccaagg cccagagtgc tgggtcagat     2100

caggaaagcc atggcgccca gagcccccta ggggaagggc agaacatggc tgtgctttca     2160

gctggtgacc cagatcccag caggtgtctc aggtcaaacc cagctgaggc ctcagacctc     2220

ctccctccag tagctggtgg tggggacacc atcacacatc agcctgactc ttgcaaagct     2280

gcccctgagc accggtcagg catcaccgct ttcatgaagg tcctgaacag tttacagaag     2340

aagcaaatga acaccagctt gtgtgagcgg atccggaagg tttatggaga cctggagtgt     2400

gaatactgtg gcaaactttt ttggtaccaa gtgcattttg atatgcatgt ccgcacccac     2460

acccgggaac atctgtatta ttgctctcag tgtcattatt cttccatcac caaaaactgc     2520

cttaaacgcc acgtaattca gaaacacagt aacatcttgc tgaagtgtcc caccgatggc     2580

tgtgactact caactccaga taaatataag ctacaggcac atcttaaagt tcacacagca     2640

ctggacaaaa ggagttattc ttgtcctgtt tgtgaaaagt ctttttcaga ggatcgattg     2700

ataaagtcac atatcaagac caaccatcct gaggtctcca tgagcaccat ttctgaggtt     2760

ctcgggagga gggttcagct gaaagggcta attggaaaga gagccatgaa atgcccatat     2820

tgtgactttt atttcatgaa gaatggctca gaccttcagc gtcatatttg ggctcatgaa     2880

ggtgtgaagc ccttcaagtg ttctttgtgt gagtatgcaa ctcgtagcaa gagtaacctc     2940

aaggctcata tgaatcgtca cagcactgag aaaacccacc tatgtgacat gtgtggcaag     3000

aaattcaaat caaaagggac actgaaaagt cacaaactcc ttcacactgc agatgggaag     3060

cagtttaagt gcacggtgtg tgactacaca gcggcccaga agccacagct gctgcggcac     3120

atggaacagc atgtctcctt caagcctttc cgctgtgccc attgccatta ctcctgcaac     3180

atatctggct ctctgaagcg gcactacaac aggaagcacc ctaatgagga gtatgccaac     3240

gtgggcaccg gggagctggc agcggaggtg ctcatccagc aaggtggttt gaagtgtcct     3300

gtttgcagct ttgtatatgg caccaaatgg gagttcaata ggcacttgaa gaacaaacat     3360

ggcttgaagg tggtggaaat tgatggagac cccaagtggg agacagcaac agaagctcct     3420

gaggagccct ccacccagta tctccacatc acagaggccg aagaagacgt tcaagggaca     3480

caggcagcgg tggccgcgct ccaggacctg agatacacct ctgagagtgg cgaccgactg     3540

gaccccacgg ccgtgaacat cctgcagcag atcattgagc tgggcgccga gacccatgac     3600

gccactgccc ttgcctcggt ggttgccatg gcaccaggga cggtgactgt ggttaagcag     3660

gtcaccgagg aggagcccag ctccaaccac acggtcatga tccaggagac ggtccagcaa     3720

gcgtccgtgg agcttgccga gcagcaccac ctggtggtgt cctccgacga cgtggagggc     3780

attgagacgg tgactgtcta cacgcagggc ggggaggcct cggagttcat cgtctacgtg     3840

caggaggcca tgcagcctgt ggaggagcag gctgtggagc agccggccca ggaactctag     3900

aggacatgtg gcatcggatg gccacagggc ggggctgcca ggctctgcag gcacccaggg     3960

tggggaggcc acccttcctg ccctacccgc agaatggtgc tctcctttgc cctccctgcc     4020

cagcagcctg ataggactct cctagtccaa cttggggtgg gcaaggcagt cagcatcacc     4080

agcaatacca caggaccctc accccagcat agacacacac cccctgaccc ttaccatctg     4140

cttcctgaaa gacttcagtg tcagctcccc tacacacacc ccacaccttc accccttgct     4200

tcaagattca aacagagact cccagtcccc ctcagcatct tccctgaatc acagccccag     4260

ctccttgacc cccatctagg tgccaaatgt tcatctgcaa ccgctatgca gtctggtgag     4320

agggagacag ccatcacata gaaagtgacc gtacgggttt ttaatcactg ctgggtgggg     4380

tgggggtagg gggattgtcc tggctttgtc gacaaagtcc cacttccccg agtattaagg     4440

gcccttggta tcaagtgagg taaattcacc catcacaggg tctcgcccta ccatcctgga     4500

attatttcac ttttaagata aatgcactat ttcactgttc gcctcccatt ctaaggaggt     4560

gaggtggttg gaataaaaac agttcctgtc tgaa                                 4594


<210>  847
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  847

Met Glu Thr Arg Ala 
1               5   


<210>  848
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  848

Asn Thr Ala Ile Phe Met Cys Lys Cys Cys Asn Leu Phe Ser Pro Asn 
1               5                   10                  15      


Gln Ser Glu Leu Leu Ser His Val Ser Glu Lys His Met Glu Glu Gly 
            20                  25                  30          


Val Asn Val Asp Glu Ile Ile Ile Pro Leu Arg Pro Leu Ser Thr Pro 
        35                  40                  45              


Glu Pro Pro Asn Ser Ser Lys Thr Gly Asp 
    50                  55              


<210>  849
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  849

Phe Leu Val Met Lys Arg Lys Arg Gly Arg Pro Lys Gly Ser Thr Lys 
1               5                   10                  15      


Lys Ser Ser Thr Glu Glu Glu Leu Ala Glu Asn Ile Val Ser Pro Thr 
            20                  25                  30          


Glu Asp Ser Pro Leu Ala Pro Glu Glu Gly Asn Ser Leu Pro Pro Ser 
        35                  40                  45              


Ser Leu Glu Cys Ser Lys Cys Cys Arg Lys Phe Ser Asn Thr Arg Gln 
    50                  55                  60                  


Leu Arg Lys His Ile Cys Ile Ile Val Leu Asn Leu Gly Glu Glu Glu 
65                  70                  75                  80  


Gly Glu Ala 
            


<210>  850
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  850

Asn Glu Ser Asp Leu Glu Leu Glu Lys Lys Cys Lys Glu Asp Asp Arg 
1               5                   10                  15      


Glu Lys Ala Ser Lys Arg Pro Arg Ser Gln Lys Thr Glu Lys Val Gln 
            20                  25                  30          


Lys Ile Ser Gly Lys Glu Ala Arg Gln Leu Ser Gly Ala Lys Lys Pro 
        35                  40                  45              


Ile Ile Ser Val Val Leu Thr Ala His Glu Ala Ile Pro 
    50                  55                  60      


<210>  851
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  851

Ala Thr Lys Ile Val Pro Val Glu Ala Gly Pro Pro Glu Thr Gly Ala 
1               5                   10                  15      


Thr Asn Ser Glu Thr Thr Ser Ala Asp Leu Val Pro Arg Arg Gly Tyr 
            20                  25                  30          


Gln Glu Tyr Ala Ile Gln Gln Thr Pro Tyr Glu Gln Pro Met Lys Ser 
        35                  40                  45              


Ser 
    


<210>  852
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  852

Leu Gly Pro Thr Gln Leu Lys Ile Phe Thr Cys Glu Tyr Cys Asn Lys 
1               5                   10                  15      


Val Phe Lys Phe Lys His Ser Leu Gln Ala His Leu Arg Ile His Thr 
            20                  25                  30          


Asn Glu Lys Pro Tyr Lys Cys Pro Gln Cys Ser Tyr Ala Ser Ala Ile 
        35                  40                  45              


Lys Ala Asn Leu Asn Val His Leu Arg Lys His Thr Gly Glu Lys Phe 
    50                  55                  60                  


Ala Cys Asp Tyr Cys Ser Phe Thr Cys Leu Ser Lys Gly His Leu Lys 
65                  70                  75                  80  


Val His Ile Glu Arg Val His Lys Lys Ile Lys Gln His Cys Arg Phe 
                85                  90                  95      


Cys Lys Lys Lys Tyr Ser Asp Val Lys Asn Leu Ile Lys His Ile Arg 
            100                 105                 110         


Asp Ala His Asp Pro Gln Asp Lys Lys Val Lys Glu Ala Leu Asp Glu 
        115                 120                 125             


Leu Cys Leu Met Thr Arg Glu Gly Lys Arg Gln Leu Leu Tyr Asp Cys 
    130                 135                 140                 


His Ile Cys Glu Arg Lys Phe Lys Asn Glu Leu Asp Arg Asp Arg His 
145                 150                 155                 160 


Met Leu Val His Gly Asp Lys Trp Pro Phe Ala Cys Glu Leu Cys Gly 
                165                 170                 175     


His Gly Ala Thr Lys Tyr Gln Ala Leu Glu Leu His Val Arg Lys His 
            180                 185                 190         


Pro Phe Val Tyr Val Cys Ala Val Cys Arg Lys Lys Phe Val Ser Ser 
        195                 200                 205             


Ile Arg Leu Arg Thr His Ile Lys Glu Val His Gly Ala Ala Gln Glu 
    210                 215                 220                 


Ala Leu Val Phe Thr Ser Ser Ile Asn Gln Ser Phe Cys Leu Leu Glu 
225                 230                 235                 240 


Pro Gly Gly Asp Ile Gln Gln Glu Ala Leu Gly Asp Gln Leu Gln Leu 
                245                 250                 255     


Val Glu Glu Glu Phe Ala Leu Gln Gly Val Asn Ala Leu Lys Glu Glu 
            260                 265                 270         


Ala Cys Pro Gly Asp Thr Gln Leu Glu Glu Gly Arg Lys Glu Pro Glu 
        275                 280                 285             


Ala Pro Gly Glu Met Pro Ala Pro Ala Val His Leu Ala Ser Pro Gln 
    290                 295                 300                 


Ala Glu Ser Thr Ala Leu Pro Pro Cys Glu Leu Glu Thr Thr Val Val 
305                 310                 315                 320 


Ser Ser Ser Asp Leu His Ser Gln Glu Val Val Ser Asp Asp Phe Leu 
                325                 330                 335     


Leu Lys Asn Asp Thr Ser Ser Ala Glu Ala His Ala Ala Pro Glu Lys 
            340                 345                 350         


Pro Pro Asp Met Gln His Arg Ser Ser Val Gln Thr Gln Gly Glu Val 
        355                 360                 365             


Ile Thr Leu Leu Leu Ser Lys Ala Gln Ser Ala Gly Ser Asp Gln Glu 
    370                 375                 380                 


Ser His Gly Ala Gln Ser Pro Leu Gly Glu Gly Gln Asn Met Ala Val 
385                 390                 395                 400 


Leu Ser Ala Gly Asp Pro Asp Pro Ser Arg Cys Leu Arg Ser Asn Pro 
                405                 410                 415     


Ala Glu Ala Ser Asp Leu Leu Pro Pro Val Ala Gly Gly Gly Asp Thr 
            420                 425                 430         


Ile Thr His Gln Pro Asp Ser Cys Lys Ala Ala Pro Glu His Arg Ser 
        435                 440                 445             


Gly Ile Thr Ala Phe Met Lys Val Leu Asn Ser Leu Gln Lys Lys Gln 
    450                 455                 460                 


Met Asn Thr Ser Leu Cys Glu Arg Ile Arg Lys Val Tyr Gly Asp Leu 
465                 470                 475                 480 


Glu Cys Glu Tyr Cys 
                485 


<210>  853
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  853

Lys Leu Phe Trp Tyr Gln Val His Phe Asp Met His Val Arg Thr His 
1               5                   10                  15      


Thr Arg Glu His Leu Tyr Tyr Cys Ser Gln Cys His Tyr Ser Ser Ile 
            20                  25                  30          


Thr Lys Asn Cys Leu Lys Arg His Val Ile Gln Lys His Ser Asn Ile 
        35                  40                  45              


Leu Leu Lys Cys Pro Thr Asp Gly Cys Asp Tyr Ser Thr Pro Asp Lys 
    50                  55                  60                  


Tyr Lys Leu Gln Ala His Leu Lys Val His Thr Ala Leu 
65                  70                  75          


<210>  854
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  854

Asp Lys Arg Ser Tyr Ser Cys Pro Val Cys Glu Lys Ser Phe Ser Glu 
1               5                   10                  15      


Asp Arg Leu Ile Lys Ser His Ile Lys Thr Asn His Pro 
            20                  25                  


<210>  855
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  855

Val Ser Met Ser Thr Ile Ser Glu Val Leu Gly Arg Arg Val Gln Leu 
1               5                   10                  15      


Lys Gly Leu Ile Gly Lys Arg Ala Met Lys Cys Pro Tyr Cys Asp Phe 
            20                  25                  30          


Tyr Phe Met Lys Asn Gly Ser Asp Leu Gln Arg His Ile Trp Ala His 
        35                  40                  45              


Glu 
    


<210>  856
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  856

Val Lys Pro Phe Lys Cys Ser Leu Cys Glu Tyr Ala Thr Arg Ser Lys 
1               5                   10                  15      


Ser Asn Leu Lys Ala His Met Asn Arg His Ser Thr Glu Lys Thr His 
            20                  25                  30          


Leu Cys Asp Met Cys Gly Lys Lys Phe Lys Ser Lys Gly Thr Leu Lys 
        35                  40                  45              


Ser His Lys Leu Leu His Thr Ala Asp 
    50                  55          


<210>  857
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  857

Lys Gln Phe Lys Cys Thr Val Cys Asp Tyr Thr Ala Ala Gln Lys Pro 
1               5                   10                  15      


Gln Leu Leu Arg His Met Glu Gln His Val Ser Phe Lys 
            20                  25                  


<210>  858
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  858

Pro Phe Arg Cys Ala His Cys His Tyr Ser Cys Asn Ile Ser Gly Ser 
1               5                   10                  15      


Leu Lys Arg His Tyr Asn Arg Lys His Pro Asn Glu Glu Tyr Ala Asn 
            20                  25                  30          


Val Gly Thr Gly Glu Leu Ala Ala Glu Val Leu Ile Gln Gln 
        35                  40                  45      


<210>  859
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  859

Gly Leu Lys Cys Pro Val Cys Ser Phe Val Tyr Gly Thr Lys Trp Glu 
1               5                   10                  15      


Phe Asn Arg His Leu Lys Asn Lys His Gly Leu Lys Val Val Glu Ile 
            20                  25                  30          


Asp Gly Asp Pro Lys Trp Glu 
        35                  


<210>  860
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  860

Thr Ala Thr Glu Ala Pro Glu Glu Pro Ser Thr Gln Tyr Leu His Ile 
1               5                   10                  15      


Thr Glu Ala Glu Glu Asp Val Gln Gly Thr Gln Ala Ala Val Ala Ala 
            20                  25                  30          


Leu Gln Asp Leu Arg Tyr Thr Ser Glu Ser 
        35                  40          


<210>  861
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  861

Asp Arg Leu Asp Pro Thr Ala Val Asn Ile Leu Gln Gln Ile Ile Glu 
1               5                   10                  15      


Leu Gly Ala Glu Thr His Asp Ala Thr Ala Leu Ala Ser Val Val Ala 
            20                  25                  30          


Met Ala Pro Gly Thr Val Thr Val Val Lys Gln 
        35                  40              


<210>  862
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  862

Val Thr Glu Glu Glu Pro Ser Ser Asn His Thr Val Met Ile Gln Glu 
1               5                   10                  15      


Thr Val Gln Gln Ala Ser Val Glu Leu Ala Glu Gln His His Leu Val 
            20                  25                  30          


Val Ser Ser Asp Asp Val Glu Gly Ile Glu Thr Val Thr Val Tyr Thr 
        35                  40                  45              


Gln Gly Gly Glu Ala Ser Glu Phe Ile Val Tyr Val Gln Glu Ala Met 
    50                  55                  60                  


Gln Pro Val Glu Glu Gln Ala Val Glu Gln Pro Ala Gln Glu Leu 
65                  70                  75                  


<210>  863
<211>  1243
<212>  PRT
<213>  Homo sapiens

<400>  863

Met Glu Thr Arg Ala Ala Glu Asn Thr Ala Ile Phe Met Cys Lys Cys 
1               5                   10                  15      


Cys Asn Leu Phe Ser Pro Asn Gln Ser Glu Leu Leu Ser His Val Ser 
            20                  25                  30          


Glu Lys His Met Glu Glu Gly Val Asn Val Asp Glu Ile Ile Ile Pro 
        35                  40                  45              


Leu Arg Pro Leu Ser Thr Pro Glu Pro Pro Asn Ser Ser Lys Thr Gly 
    50                  55                  60                  


Asp Glu Phe Leu Val Met Lys Arg Lys Arg Gly Arg Pro Lys Gly Ser 
65                  70                  75                  80  


Thr Lys Lys Ser Ser Thr Glu Glu Glu Leu Ala Glu Asn Ile Val Ser 
                85                  90                  95      


Pro Thr Glu Asp Ser Pro Leu Ala Pro Glu Glu Gly Asn Ser Leu Pro 
            100                 105                 110         


Pro Ser Ser Leu Glu Cys Ser Lys Cys Cys Arg Lys Phe Ser Asn Thr 
        115                 120                 125             


Arg Gln Leu Arg Lys His Ile Cys Ile Ile Val Leu Asn Leu Gly Glu 
    130                 135                 140                 


Glu Glu Gly Glu Ala Gly Asn Glu Ser Asp Leu Glu Leu Glu Lys Lys 
145                 150                 155                 160 


Cys Lys Glu Asp Asp Arg Glu Lys Ala Ser Lys Arg Pro Arg Ser Gln 
                165                 170                 175     


Lys Thr Glu Lys Val Gln Lys Ile Ser Gly Lys Glu Ala Arg Gln Leu 
            180                 185                 190         


Ser Gly Ala Lys Lys Pro Ile Ile Ser Val Val Leu Thr Ala His Glu 
        195                 200                 205             


Ala Ile Pro Gly Ala Thr Lys Ile Val Pro Val Glu Ala Gly Pro Pro 
    210                 215                 220                 


Glu Thr Gly Ala Thr Asn Ser Glu Thr Thr Ser Ala Asp Leu Val Pro 
225                 230                 235                 240 


Arg Arg Gly Tyr Gln Glu Tyr Ala Ile Gln Gln Thr Pro Tyr Glu Gln 
                245                 250                 255     


Pro Met Lys Ser Ser Arg Leu Gly Pro Thr Gln Leu Lys Ile Phe Thr 
            260                 265                 270         


Cys Glu Tyr Cys Asn Lys Val Phe Lys Phe Lys His Ser Leu Gln Ala 
        275                 280                 285             


His Leu Arg Ile His Thr Asn Glu Lys Pro Tyr Lys Cys Pro Gln Cys 
    290                 295                 300                 


Ser Tyr Ala Ser Ala Ile Lys Ala Asn Leu Asn Val His Leu Arg Lys 
305                 310                 315                 320 


His Thr Gly Glu Lys Phe Ala Cys Asp Tyr Cys Ser Phe Thr Cys Leu 
                325                 330                 335     


Ser Lys Gly His Leu Lys Val His Ile Glu Arg Val His Lys Lys Ile 
            340                 345                 350         


Lys Gln His Cys Arg Phe Cys Lys Lys Lys Tyr Ser Asp Val Lys Asn 
        355                 360                 365             


Leu Ile Lys His Ile Arg Asp Ala His Asp Pro Gln Asp Lys Lys Val 
    370                 375                 380                 


Lys Glu Ala Leu Asp Glu Leu Cys Leu Met Thr Arg Glu Gly Lys Arg 
385                 390                 395                 400 


Gln Leu Leu Tyr Asp Cys His Ile Cys Glu Arg Lys Phe Lys Asn Glu 
                405                 410                 415     


Leu Asp Arg Asp Arg His Met Leu Val His Gly Asp Lys Trp Pro Phe 
            420                 425                 430         


Ala Cys Glu Leu Cys Gly His Gly Ala Thr Lys Tyr Gln Ala Leu Glu 
        435                 440                 445             


Leu His Val Arg Lys His Pro Phe Val Tyr Val Cys Ala Val Cys Arg 
    450                 455                 460                 


Lys Lys Phe Val Ser Ser Ile Arg Leu Arg Thr His Ile Lys Glu Val 
465                 470                 475                 480 


His Gly Ala Ala Gln Glu Ala Leu Val Phe Thr Ser Ser Ile Asn Gln 
                485                 490                 495     


Ser Phe Cys Leu Leu Glu Pro Gly Gly Asp Ile Gln Gln Glu Ala Leu 
            500                 505                 510         


Gly Asp Gln Leu Gln Leu Val Glu Glu Glu Phe Ala Leu Gln Gly Val 
        515                 520                 525             


Asn Ala Leu Lys Glu Glu Ala Cys Pro Gly Asp Thr Gln Leu Glu Glu 
    530                 535                 540                 


Gly Arg Lys Glu Pro Glu Ala Pro Gly Glu Met Pro Ala Pro Ala Val 
545                 550                 555                 560 


His Leu Ala Ser Pro Gln Ala Glu Ser Thr Ala Leu Pro Pro Cys Glu 
                565                 570                 575     


Leu Glu Thr Thr Val Val Ser Ser Ser Asp Leu His Ser Gln Glu Val 
            580                 585                 590         


Val Ser Asp Asp Phe Leu Leu Lys Asn Asp Thr Ser Ser Ala Glu Ala 
        595                 600                 605             


His Ala Ala Pro Glu Lys Pro Pro Asp Met Gln His Arg Ser Ser Val 
    610                 615                 620                 


Gln Thr Gln Gly Glu Val Ile Thr Leu Leu Leu Ser Lys Ala Gln Ser 
625                 630                 635                 640 


Ala Gly Ser Asp Gln Glu Ser His Gly Ala Gln Ser Pro Leu Gly Glu 
                645                 650                 655     


Gly Gln Asn Met Ala Val Leu Ser Ala Gly Asp Pro Asp Pro Ser Arg 
            660                 665                 670         


Cys Leu Arg Ser Asn Pro Ala Glu Ala Ser Asp Leu Leu Pro Pro Val 
        675                 680                 685             


Ala Gly Gly Gly Asp Thr Ile Thr His Gln Pro Asp Ser Cys Lys Ala 
    690                 695                 700                 


Ala Pro Glu His Arg Ser Gly Ile Thr Ala Phe Met Lys Val Leu Asn 
705                 710                 715                 720 


Ser Leu Gln Lys Lys Gln Met Asn Thr Ser Leu Cys Glu Arg Ile Arg 
                725                 730                 735     


Lys Val Tyr Gly Asp Leu Glu Cys Glu Tyr Cys Gly Lys Leu Phe Trp 
            740                 745                 750         


Tyr Gln Val His Phe Asp Met His Val Arg Thr His Thr Arg Glu His 
        755                 760                 765             


Leu Tyr Tyr Cys Ser Gln Cys His Tyr Ser Ser Ile Thr Lys Asn Cys 
    770                 775                 780                 


Leu Lys Arg His Val Ile Gln Lys His Ser Asn Ile Leu Leu Lys Cys 
785                 790                 795                 800 


Pro Thr Asp Gly Cys Asp Tyr Ser Thr Pro Asp Lys Tyr Lys Leu Gln 
                805                 810                 815     


Ala His Leu Lys Val His Thr Ala Leu Asp Lys Arg Ser Tyr Ser Cys 
            820                 825                 830         


Pro Val Cys Glu Lys Ser Phe Ser Glu Asp Arg Leu Ile Lys Ser His 
        835                 840                 845             


Ile Lys Thr Asn His Pro Glu Val Ser Met Ser Thr Ile Ser Glu Val 
    850                 855                 860                 


Leu Gly Arg Arg Val Gln Leu Lys Gly Leu Ile Gly Lys Arg Ala Met 
865                 870                 875                 880 


Lys Cys Pro Tyr Cys Asp Phe Tyr Phe Met Lys Asn Gly Ser Asp Leu 
                885                 890                 895     


Gln Arg His Ile Trp Ala His Glu Gly Val Lys Pro Phe Lys Cys Ser 
            900                 905                 910         


Leu Cys Glu Tyr Ala Thr Arg Ser Lys Ser Asn Leu Lys Ala His Met 
        915                 920                 925             


Asn Arg His Ser Thr Glu Lys Thr His Leu Cys Asp Met Cys Gly Lys 
    930                 935                 940                 


Lys Phe Lys Ser Lys Gly Thr Leu Lys Ser His Lys Leu Leu His Thr 
945                 950                 955                 960 


Ala Asp Gly Lys Gln Phe Lys Cys Thr Val Cys Asp Tyr Thr Ala Ala 
                965                 970                 975     


Gln Lys Pro Gln Leu Leu Arg His Met Glu Gln His Val Ser Phe Lys 
            980                 985                 990         


Pro Phe Arg Cys Ala His Cys His  Tyr Ser Cys Asn Ile  Ser Gly Ser 
        995                 1000                 1005             


Leu Lys  Arg His Tyr Asn Arg  Lys His Pro Asn Glu  Glu Tyr Ala 
    1010                 1015                 1020             


Asn Val  Gly Thr Gly Glu Leu  Ala Ala Glu Val Leu  Ile Gln Gln 
    1025                 1030                 1035             


Gly Gly  Leu Lys Cys Pro Val  Cys Ser Phe Val Tyr  Gly Thr Lys 
    1040                 1045                 1050             


Trp Glu  Phe Asn Arg His Leu  Lys Asn Lys His Gly  Leu Lys Val 
    1055                 1060                 1065             


Val Glu  Ile Asp Gly Asp Pro  Lys Trp Glu Thr Ala  Thr Glu Ala 
    1070                 1075                 1080             


Pro Glu  Glu Pro Ser Thr Gln  Tyr Leu His Ile Thr  Glu Ala Glu 
    1085                 1090                 1095             


Glu Asp  Val Gln Gly Thr Gln  Ala Ala Val Ala Ala  Leu Gln Asp 
    1100                 1105                 1110             


Leu Arg  Tyr Thr Ser Glu Ser  Gly Asp Arg Leu Asp  Pro Thr Ala 
    1115                 1120                 1125             


Val Asn  Ile Leu Gln Gln Ile  Ile Glu Leu Gly Ala  Glu Thr His 
    1130                 1135                 1140             


Asp Ala  Thr Ala Leu Ala Ser  Val Val Ala Met Ala  Pro Gly Thr 
    1145                 1150                 1155             


Val Thr  Val Val Lys Gln Val  Thr Glu Glu Glu Pro  Ser Ser Asn 
    1160                 1165                 1170             


His Thr  Val Met Ile Gln Glu  Thr Val Gln Gln Ala  Ser Val Glu 
    1175                 1180                 1185             


Leu Ala  Glu Gln His His Leu  Val Val Ser Ser Asp  Asp Val Glu 
    1190                 1195                 1200             


Gly Ile  Glu Thr Val Thr Val  Tyr Thr Gln Gly Gly  Glu Ala Ser 
    1205                 1210                 1215             


Glu Phe  Ile Val Tyr Val Gln  Glu Ala Met Gln Pro  Val Glu Glu 
    1220                 1225                 1230             


Gln Ala  Val Glu Gln Pro Ala  Gln Glu Leu 
    1235                 1240             


<210>  864
<211>  3283
<212>  DNA
<213>  Homo sapiens

<400>  864
atccgccatg ttggatgccg cagattcgcc ataacctcgc cggctctttt cttaaaaaaa       60

taaaaataaa aagcgaagcg tcagcagggc gccccgcccc ctcggtcggc acgggagggg      120

gcccggaaga gcccgaggct tttttttcct ccgcggtggg gcgttgccat ggagacgcgg      180

gcggcagaaa acacggccat ctttatgtgt aaatgttgta acctcttctc accaaatcag      240

tcggaactcc tctcccacgt ttcagagaag cacatggaag aaggggttaa tgttgatgag      300

attattattc cccttaggcc tctgagtaca cctgaacccc ccaactcaag caaaaccgga      360

gatgagtttt tggtcatgaa gaggaagaga ggcaggccta aggggtccac gaagaagtcc      420

agcacagaag aggagctggc agaaaacatc gtgagtccga ctgaggacag cccgctggct      480

ccggaggaag ggaacagcct gcctccaagc agcttggagt gtagcaagtg ctgtcggaag      540

ttctccaaca cgcgccagct gcggaagcac atctgcatta tcgtgctgaa tttgggtgag      600

gaggaaggag aagcaggtaa cgagtctgac cttgaactag aaaagaagtg taaggaagat      660

gatcgggaaa aagcctcgaa aagaccacgg tcacagaaaa cagagaaagt ccagaagatc      720

tcaggaaagg aggccagaca gctttctggg gcgaagaaac ccatcataag tgtggtttta      780

actgcacacg aagcaattcc aggtgctacc aagattgtgc cagtggaggc tgggccccct      840

gaaacaggag ctacaaattc tgagaccact tcagcagacc tggtgcctcg gagaggctac      900

caggaatacg ccattcagca gacaccttat gagcaaccaa tgaagtcaag caggctaggt      960

cccactcagc tcaaaatctt cacttgtgaa tactgcaaca aggtcttcaa gttcaagcac     1020

tcgctgcagg cccacctgag gatccacacc aatgaaaagc catacaagtg cccccagtgc     1080

agctatgcca gtgccatcaa ggccaacctc aatgtgcacc tgcgcaagca cactggagag     1140

aagttcgcct gcgactattg ctcgttcacc tgcctgagca agggccacct caaggtgcac     1200

atcgagcgag tgcacaagaa gatcaagcag cactgccgct tctgcaagaa gaagtactct     1260

gacgtcaaga acctcatcaa gcacatccga gacgcgcatg acccacagga caagaaggtc     1320

aaagaggcct tggacgagct ctgcctgatg acgagggagg gcaagcggca gctgctctat     1380

gactgccaca tctgtgagcg caagttcaag aacgagctgg accgtgaccg ccatatgctg     1440

gtccacggag acaagtggcc ttttgcctgt gagctctgtg gccatggggc caccaagtac     1500

caggcgctgg aactgcatgt caggaagcac cccttcgtgt acgtctgtgc cgtctgccgc     1560

aagaagttcg tcagctccat caggctgcgc acccacatca aagaggtgca cggggctgcc     1620

caggaggcct tggtcttcac cagttccatc aaccagagct tctgcctcct ggaacctggt     1680

ggggacatcc agcaagaagc tctgggggac cagctacagc tggtggaaga ggagtttgcc     1740

ctccagggcg tgaatgcact caaggaagag gcctgtcctg gggacactca gctggaggag     1800

ggccggaagg agccggaggc ccctggggaa atgcctgccc cagctgtgca cctggcctcc     1860

ccgcaggccg aaagcacagc cctgccaccc tgtgagctgg aaaccaccgt ggtctcctcc     1920

tcagacctgc attctcaaga ggtggtttca gatgattttt tgttgaaaaa tgatacctcc     1980

tccgcagagg ctcatgctgc tcctgagaag cccccagaca tgcagcacag aagctcagtc     2040

cagacgcaag gtgaagtgat cacactactg ctgtccaagg cccagagtgc tgggtcagat     2100

caggaaagcc atggcgccca gagcccccta ggggaagggc agaacatggc tgtgctttca     2160

gctggtgacc cagatcccag caggtgtctc aggtcaaacc cagctgaggc ctcagacctc     2220

ctccctccag tagctggtgg tggggacacc atcacacatc agcctgactc ttgcaaagct     2280

gcccctgagc accggtcagg catcaccgct ttcatgaagg tcctgaacag tttacagaag     2340

aagcaaatga acaccagctt gtgtgagcgg atccggaagg tttatggaga cctggagtgt     2400

gaatactgtg gcaaactttt ttggtaccaa gtgcattttg atatgcatgt ccgcacccac     2460

acccgggaac atctgtatta ttgctctcag tgtcattatt cttccatcac caaaaactgc     2520

cttaaacgcc acgtaattca gaaacacagt aacatcttgc tgaagtgtcc caccgatggc     2580

tgtgactact caactccaga taaatataag ctacaggcac atcttaaagt tcacacagca     2640

ctggacaaaa ggagttattc ttgtcctgtt tgtgaaaagt ctttttcaga ggatcgattg     2700

ataaagtcac atatcaagac caaccatcct gaggtctcca tgagcaccat ttctgaggtt     2760

ctcgggagga gggttcagct gaaagggcta attggaaaga gagccatgaa atgcccatat     2820

tgtgactttt atttcatgaa gaatggctca gaccttcagc gtcatatttg ggctcatgaa     2880

ggtgtgaagc ccttcaagtg ttctttgtgt gagtatgcaa ctcgtagcaa gagtaacctc     2940

aaggctcata tgaatcgtca cagcactgag aaaacccacc tatgtgacat gtgtggcaag     3000

aaattcaaat caaaagggac actgaaaagt cacaaactcc ttcacactgc agatgggaag     3060

cagtttaagt gcacggtgtg tgactacaca gcggcccaga agccacagct gctgcggcac     3120

atggaacagc atgtctcctt caagcctttc cgctgtgccc attgccatta ctcctgcaac     3180

atatctggct ctctgaagcg gcactacaac aggaagcacc ctaatgagga gtatgccaac     3240

gtgggcaccg gggagctggc agcggaggtg ctcatccagc aag                       3283


<210>  865
<211>  1038
<212>  PRT
<213>  Homo sapiens

<400>  865

Met Glu Thr Arg Ala Ala Glu Asn Thr Ala Ile Phe Met Cys Lys Cys 
1               5                   10                  15      


Cys Asn Leu Phe Ser Pro Asn Gln Ser Glu Leu Leu Ser His Val Ser 
            20                  25                  30          


Glu Lys His Met Glu Glu Gly Val Asn Val Asp Glu Ile Ile Ile Pro 
        35                  40                  45              


Leu Arg Pro Leu Ser Thr Pro Glu Pro Pro Asn Ser Ser Lys Thr Gly 
    50                  55                  60                  


Asp Glu Phe Leu Val Met Lys Arg Lys Arg Gly Arg Pro Lys Gly Ser 
65                  70                  75                  80  


Thr Lys Lys Ser Ser Thr Glu Glu Glu Leu Ala Glu Asn Ile Val Ser 
                85                  90                  95      


Pro Thr Glu Asp Ser Pro Leu Ala Pro Glu Glu Gly Asn Ser Leu Pro 
            100                 105                 110         


Pro Ser Ser Leu Glu Cys Ser Lys Cys Cys Arg Lys Phe Ser Asn Thr 
        115                 120                 125             


Arg Gln Leu Arg Lys His Ile Cys Ile Ile Val Leu Asn Leu Gly Glu 
    130                 135                 140                 


Glu Glu Gly Glu Ala Gly Asn Glu Ser Asp Leu Glu Leu Glu Lys Lys 
145                 150                 155                 160 


Cys Lys Glu Asp Asp Arg Glu Lys Ala Ser Lys Arg Pro Arg Ser Gln 
                165                 170                 175     


Lys Thr Glu Lys Val Gln Lys Ile Ser Gly Lys Glu Ala Arg Gln Leu 
            180                 185                 190         


Ser Gly Ala Lys Lys Pro Ile Ile Ser Val Val Leu Thr Ala His Glu 
        195                 200                 205             


Ala Ile Pro Gly Ala Thr Lys Ile Val Pro Val Glu Ala Gly Pro Pro 
    210                 215                 220                 


Glu Thr Gly Ala Thr Asn Ser Glu Thr Thr Ser Ala Asp Leu Val Pro 
225                 230                 235                 240 


Arg Arg Gly Tyr Gln Glu Tyr Ala Ile Gln Gln Thr Pro Tyr Glu Gln 
                245                 250                 255     


Pro Met Lys Ser Ser Arg Leu Gly Pro Thr Gln Leu Lys Ile Phe Thr 
            260                 265                 270         


Cys Glu Tyr Cys Asn Lys Val Phe Lys Phe Lys His Ser Leu Gln Ala 
        275                 280                 285             


His Leu Arg Ile His Thr Asn Glu Lys Pro Tyr Lys Cys Pro Gln Cys 
    290                 295                 300                 


Ser Tyr Ala Ser Ala Ile Lys Ala Asn Leu Asn Val His Leu Arg Lys 
305                 310                 315                 320 


His Thr Gly Glu Lys Phe Ala Cys Asp Tyr Cys Ser Phe Thr Cys Leu 
                325                 330                 335     


Ser Lys Gly His Leu Lys Val His Ile Glu Arg Val His Lys Lys Ile 
            340                 345                 350         


Lys Gln His Cys Arg Phe Cys Lys Lys Lys Tyr Ser Asp Val Lys Asn 
        355                 360                 365             


Leu Ile Lys His Ile Arg Asp Ala His Asp Pro Gln Asp Lys Lys Val 
    370                 375                 380                 


Lys Glu Ala Leu Asp Glu Leu Cys Leu Met Thr Arg Glu Gly Lys Arg 
385                 390                 395                 400 


Gln Leu Leu Tyr Asp Cys His Ile Cys Glu Arg Lys Phe Lys Asn Glu 
                405                 410                 415     


Leu Asp Arg Asp Arg His Met Leu Val His Gly Asp Lys Trp Pro Phe 
            420                 425                 430         


Ala Cys Glu Leu Cys Gly His Gly Ala Thr Lys Tyr Gln Ala Leu Glu 
        435                 440                 445             


Leu His Val Arg Lys His Pro Phe Val Tyr Val Cys Ala Val Cys Arg 
    450                 455                 460                 


Lys Lys Phe Val Ser Ser Ile Arg Leu Arg Thr His Ile Lys Glu Val 
465                 470                 475                 480 


His Gly Ala Ala Gln Glu Ala Leu Val Phe Thr Ser Ser Ile Asn Gln 
                485                 490                 495     


Ser Phe Cys Leu Leu Glu Pro Gly Gly Asp Ile Gln Gln Glu Ala Leu 
            500                 505                 510         


Gly Asp Gln Leu Gln Leu Val Glu Glu Glu Phe Ala Leu Gln Gly Val 
        515                 520                 525             


Asn Ala Leu Lys Glu Glu Ala Cys Pro Gly Asp Thr Gln Leu Glu Glu 
    530                 535                 540                 


Gly Arg Lys Glu Pro Glu Ala Pro Gly Glu Met Pro Ala Pro Ala Val 
545                 550                 555                 560 


His Leu Ala Ser Pro Gln Ala Glu Ser Thr Ala Leu Pro Pro Cys Glu 
                565                 570                 575     


Leu Glu Thr Thr Val Val Ser Ser Ser Asp Leu His Ser Gln Glu Val 
            580                 585                 590         


Val Ser Asp Asp Phe Leu Leu Lys Asn Asp Thr Ser Ser Ala Glu Ala 
        595                 600                 605             


His Ala Ala Pro Glu Lys Pro Pro Asp Met Gln His Arg Ser Ser Val 
    610                 615                 620                 


Gln Thr Gln Gly Glu Val Ile Thr Leu Leu Leu Ser Lys Ala Gln Ser 
625                 630                 635                 640 


Ala Gly Ser Asp Gln Glu Ser His Gly Ala Gln Ser Pro Leu Gly Glu 
                645                 650                 655     


Gly Gln Asn Met Ala Val Leu Ser Ala Gly Asp Pro Asp Pro Ser Arg 
            660                 665                 670         


Cys Leu Arg Ser Asn Pro Ala Glu Ala Ser Asp Leu Leu Pro Pro Val 
        675                 680                 685             


Ala Gly Gly Gly Asp Thr Ile Thr His Gln Pro Asp Ser Cys Lys Ala 
    690                 695                 700                 


Ala Pro Glu His Arg Ser Gly Ile Thr Ala Phe Met Lys Val Leu Asn 
705                 710                 715                 720 


Ser Leu Gln Lys Lys Gln Met Asn Thr Ser Leu Cys Glu Arg Ile Arg 
                725                 730                 735     


Lys Val Tyr Gly Asp Leu Glu Cys Glu Tyr Cys Gly Lys Leu Phe Trp 
            740                 745                 750         


Tyr Gln Val His Phe Asp Met His Val Arg Thr His Thr Arg Glu His 
        755                 760                 765             


Leu Tyr Tyr Cys Ser Gln Cys His Tyr Ser Ser Ile Thr Lys Asn Cys 
    770                 775                 780                 


Leu Lys Arg His Val Ile Gln Lys His Ser Asn Ile Leu Leu Lys Cys 
785                 790                 795                 800 


Pro Thr Asp Gly Cys Asp Tyr Ser Thr Pro Asp Lys Tyr Lys Leu Gln 
                805                 810                 815     


Ala His Leu Lys Val His Thr Ala Leu Asp Lys Arg Ser Tyr Ser Cys 
            820                 825                 830         


Pro Val Cys Glu Lys Ser Phe Ser Glu Asp Arg Leu Ile Lys Ser His 
        835                 840                 845             


Ile Lys Thr Asn His Pro Glu Val Ser Met Ser Thr Ile Ser Glu Val 
    850                 855                 860                 


Leu Gly Arg Arg Val Gln Leu Lys Gly Leu Ile Gly Lys Arg Ala Met 
865                 870                 875                 880 


Lys Cys Pro Tyr Cys Asp Phe Tyr Phe Met Lys Asn Gly Ser Asp Leu 
                885                 890                 895     


Gln Arg His Ile Trp Ala His Glu Gly Val Lys Pro Phe Lys Cys Ser 
            900                 905                 910         


Leu Cys Glu Tyr Ala Thr Arg Ser Lys Ser Asn Leu Lys Ala His Met 
        915                 920                 925             


Asn Arg His Ser Thr Glu Lys Thr His Leu Cys Asp Met Cys Gly Lys 
    930                 935                 940                 


Lys Phe Lys Ser Lys Gly Thr Leu Lys Ser His Lys Leu Leu His Thr 
945                 950                 955                 960 


Ala Asp Gly Lys Gln Phe Lys Cys Thr Val Cys Asp Tyr Thr Ala Ala 
                965                 970                 975     


Gln Lys Pro Gln Leu Leu Arg His Met Glu Gln His Val Ser Phe Lys 
            980                 985                 990         


Pro Phe Arg Cys Ala His Cys His  Tyr Ser Cys Asn Ile  Ser Gly Ser 
        995                 1000                 1005             


Leu Lys  Arg His Tyr Asn Arg  Lys His Pro Asn Glu  Glu Tyr Ala 
    1010                 1015                 1020             


Asn Val  Gly Thr Gly Glu Leu  Ala Ala Glu Val Leu  Ile Gln Gln 
    1025                 1030                 1035             


<210>  866
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  866
gcctcatccc ctcttcagtg caggaatatg ttagcgttgt atcttgggag aaagacacag       60

tctccatcat cccag                                                        75


<210>  867
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  867
ccttgcctcc ccgattgaaa gagatgaaaa gccaggaatc ggctgcaggt tccaaactag       60

tccttcggtg tgaaa                                                        75


<210>  868
<211>  150
<212>  DNA
<213>  Homo sapiens

<400>  868
gcctcatccc ctcttcagtg caggaatatg ttagcgttgt atcttgggag aaagacacag       60

tctccatcat cccagccttg cctccccgat tgaaagagat gaaaagccag gaatcggctg      120

caggttccaa actagtcctt cggtgtgaaa                                       150


<210>  869
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  869

Leu Ile Pro Ser Ser Val Gln Glu Tyr Val Ser Val Val Ser Trp Glu 
1               5                   10                  15      


Lys Asp Thr Val Ser Ile Ile Pro Ala Leu Pro Pro Arg Leu Lys Glu 
            20                  25                  30          


Met Lys Ser Gln Glu Ser Ala Ala Gly Ser Lys Leu Val Leu Arg Cys 
        35                  40                  45              


Glu 
    


<210>  870
<211>  183
<212>  DNA
<213>  Homo sapiens

<400>  870
agccgagcgc tgggctgagg agcagagaga gcggggcgcc gagtgcgggc ggctgggagc       60

gcgctgagcg ggggagaggc gctgccgcac ggccggccac aggaccacct ccccggagaa      120

tagggcctct ttatggcatg tggctggtaa ctttcctcct gctcctggac tctttacaca      180

aag                                                                    183


<210>  871
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  871
cccgccctga agatgttggc accagcctct actttgtaaa tgactccttg cagcaggtga       60

ccttttccag ctccgtgggg gtggtggtgc cctgcccggc cgcgggctcc cccagcgcgg      120

cccttcgatg gtacctggcc acaggggacg acatctacga cgtgccgcac atccggcacg      180

tccacgccaa cgggacgctg cagctctacc ccttctcccc ctccgccttc aatagcttta      240

tccacgacaa tgactacttc tgcaccgcgg agaacgctgc cggcaagatc cggagcccca      300

acatccgcgt caaagcag                                                    318


<210>  872
<211>  147
<212>  DNA
<213>  Homo sapiens

<400>  872
ttttcaggga accctacacc gtccgggtgg aggatcaaag gtcaatgcgt ggcaacgtgg       60

ccgtcttcaa gtgcctcatc ccctcttcag tgcaggaata tgttagcgtt gtatcttggg      120

agaaagacac agtctccatc atcccag                                          147


<210>  873
<211>  147
<212>  DNA
<213>  Homo sapiens

<400>  873
aacacaggtt ttttattacc taccacggcg ggctgtacat ctctgacgta cagaaggagg       60

acgccctctc cacctatcgc tgcatcacca agcacaagta tagcggggag acccggcaga      120

gcaatggggc acgcctctct gtgacag                                          147


<210>  874
<211>  279
<212>  DNA
<213>  Homo sapiens

<400>  874
accctgctga gtcgatcccc accatcctgg atggcttcca ctcccaggaa gtgtgggccg       60

gccacaccgt ggagctgccc tgcaccgcct cgggctaccc tatccccgcc atccgctggc      120

tcaaggatgg ccggcccctc ccggctgaca gccgctggac caagcgcatc acagggctga      180

ccatcagcga cttgcggacc gaggacagcg gcacctacat ttgtgaggtc accaacacct      240

tcggttcggc agaggccaca ggcatcctca tggtcattg                             279


<210>  875
<211>  276
<212>  DNA
<213>  Homo sapiens

<400>  875
atccccttca tgtgaccctg acaccaaaga agctgaagac cggcattggc agcacggtca       60

tcctctcctg tgccctgacg ggctccccag agttcaccat ccgctggtat cgcaacacgg      120

agctggtgct gcctgacgag gccatctcca tccgcgggct cagcaacgag acgctgctca      180

tcacctcggc ccagaagagc cattccgggg cctaccagtg cttcgctacc cgcaaggccc      240

agaccgccca ggactttgcc atcattgcac ttgagg                                276


<210>  876
<211>  297
<212>  DNA
<213>  Homo sapiens

<400>  876
atggcacgcc ccgcatcgtc tcgtccttca gcgagaaggt ggtcaacccc ggggagcagt       60

tctcactgat gtgtgcggcc aagggcgccc cgccccccac ggtcacctgg gccctcgacg      120

atgagcccat cgtgcgggat ggcagccacc gcaccaacca gtacaccatg tcggacggca      180

ccaccatcag ccacatgaac gtcacaggcc cccagatccg cgacgggggc gtgtaccggt      240

gcacagcgcg gaacttggtg ggcagtgctg aatatcaggc gcgaataaac gtaagag         297


<210>  877
<211>  273
<212>  DNA
<213>  Homo sapiens

<400>  877
gcccacccag catccgggct atgcggaaca tcacagcagt cgccgggcgg gacaccctta       60

tcaactgcag ggtcatcggc tatccctact actccatcaa gtggtacaag gatgccctgc      120

tgctgccaga caaccaccgc caggtggtgt ttgagaatgg gaccctcaag ctgactgacg      180

tgcagaaggg catggatgag ggggagtacc tgtgcagtgt cctcatccag ccccagctct      240

ccatcagcca gagcgttcac gtagccgtca aag                                   273


<210>  878
<211>  279
<212>  DNA
<213>  Homo sapiens

<400>  878
tgccccctct gatccagccc ttcgaattcc cacccgcctc catcggccag ctgctctaca       60

ttccctgtgt ggtgtcctcg ggggacatgc ccatccgtat cacctggagg aaggacggac      120

aggtgatcat ctcaggctcg ggcgtgacca tcgagagcaa ggaattcatg agctccctgc      180

agatctctag cgtctccctc aagcacaacg gcaactatac atgcatcgcc agcaacgcag      240

ccgccaccgt gagccgggag cgccagctca tcgtgcgtg                             279


<210>  879
<211>  120
<212>  DNA
<213>  Homo sapiens

<400>  879
tgccccctcg atttgtggtg caacccaaca accaggatgg catctacggc aaagctggtg       60

tgctcaactg ctcggtggac ggctaccccc cacccaaggt catgtggaag catgccaagg      120


<210>  880
<211>  177
<212>  DNA
<213>  Homo sapiens

<400>  880
ggagcgggaa cccccagcag taccaccctg tgcccctcac tggccgcatc cagatcctgc       60

ccaacagctc gctgctgatc cgccacgtcc tagaagagga catcggctac tacctctgcc      120

aggccagcaa cggcgtaggc accgacatca gcaagtccat gttcctcaca gtcaaga         177


<210>  881
<211>  200
<212>  DNA
<213>  Homo sapiens

<400>  881
tcccggccat gatcacttcc caccccaaca ccaccatcgc catcaagggc catgcgaagg       60

agctaaactg cacggcacgg ggtgagcggc ccatcatcat ccgctgggag aagggggaca      120

cagtcatcga ccctgaccgc gtcatgcggt atgccatcgc caccaaggac aacggcgacg      180

aggtcgtctc cacactgaag                                                  200


<210>  882
<211>  97
<212>  DNA
<213>  Homo sapiens

<400>  882
ctcaagcccg ctgaccgtgg ggactctgtg ttcttcagct gccatgccat caactcgtat       60

ggggaggacc ggggcttgat ccaactcact gtgcaag                                97


<210>  883
<211>  129
<212>  DNA
<213>  Homo sapiens

<400>  883
agccccccga ccccccagag ctggagatcc gggaggtgaa ggcccggagc atgaacctgc       60

gctggaccca gcgattcgac gggaacagca tcatcacggg cttcgacatt gaatacaaga      120

acaaatcag                                                              129


<210>  884
<211>  168
<212>  DNA
<213>  Homo sapiens

<400>  884
attcctggga cttcaagcag tccacacgca acatctcccc caccatcaac caggccaaca       60

ttgtggactt gcacccggca tctgtgtaca gcatccgcat gtactctttc aacaagattg      120

gccgcagtga accaagcaag gagctcacca tcagcactga ggaggccg                   168


<210>  885
<211>  71
<212>  DNA
<213>  Homo sapiens

<400>  885
ctcccgatgg gccccccatg gatgttacct tgcagccagt gacctcacag agcatccagg       60

tgacctggaa g                                                            71


<210>  886
<211>  241
<212>  DNA
<213>  Homo sapiens

<400>  886
gcacccaaga aggagctgca gaacggtgtc atccggggct accagattgg ctacagagag       60

aacagccccg gcagcaacgg gcagtacagc atcgtggaga tgaaggccac gggggacagc      120

gaggtctaca ccctggacaa cctcaagaag ttcgcccagt atggggtggt ggtccaagcc      180

ttcaatcggg ctggcacggg gccctcttcc agcgagatca atgccaccac tctggaggat      240

g                                                                      241


<210>  887
<211>  147
<212>  DNA
<213>  Homo sapiens

<400>  887
tgcccagcca gccccctgag aacgtccggg ccctgtccat cacttctgac gtggccgtca       60

tctcctggtc agagcccccg cgcagcaccc tcaatggcgt cctcaaaggc tatcgggtca      120

tcttctggtc cctctatgtt gatgggg                                          147


<210>  888
<211>  156
<212>  DNA
<213>  Homo sapiens

<400>  888
agtggggcga gatgcagaac atcaccacca cgcgggagcg ggtggagctg cggggcatgg       60

agaagttcac caactacagc gtccaggtgc tggcctacac ccaggctggg gacggcgtac      120

gcagcagtgt gctctacatc cagaccaagg aggacg                                156


<210>  889
<211>  140
<212>  DNA
<213>  Homo sapiens

<400>  889
ttccaggtcc ccctgctggc atcaaagctg tcccttcatc agctagcagt gtggttgtgt       60

cttggctccc ccctaccaag cccaacgggg tgatccgcaa gtacaccatc ttctgttcca      120

gccccgggtc tggccagccg                                                  140


<210>  890
<211>  154
<212>  DNA
<213>  Homo sapiens

<400>  890
gctcccagcg agtacgagac gagtccagag cagctcttct accggatcgc ccacctaaac       60

cgcggtcagc agtatctgct gtgggtggcc gccgtcacct ctgccggccg gggcaacagc      120

agcgagaagg tgaccatcga gcctgctggc aagg                                  154


<210>  891
<211>  118
<212>  DNA
<213>  Homo sapiens

<400>  891
ccccagcaaa gatcatctcc tttgggggca ccgtgacaac accttggatg aaagatgttc       60

ggctgccttg caattcagtg ggagatccag cccctgctgt gaagtggacc aaggacag        118


<210>  892
<211>  164
<212>  DNA
<213>  Homo sapiens

<400>  892
tgaagactcg gccattccag tgtccatgga tgggcaccgg ctcatccaca ccaatggcac       60

actgctgctg cgtgcagtga aggctgagga ctctggctac tacacgtgca cggccaccaa      120

cactggtggc tttgacacca tcatcgtcaa ccttctggtg caag                       164


<210>  893
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  893
ttcccccgga ccagccccgc ctcactgtct ccaaaacctc agcttcgtcc atcaccctga       60

cctggattcc aggtgacaat gggggcagct ccatccgag                              99


<210>  894
<211>  189
<212>  DNA
<213>  Homo sapiens

<400>  894
gcttcgtgct acagtactcg gtggacaaca gcgaggagtg gaaggatgtg ttcatcagct       60

ccagcgagcg ctccttcaag ctggacagcc tcaagtgtgg cacgtggtac aaggtgaagc      120

tggcagccaa gaacagcgtg ggctctgggc gcatcagcga gatcatcgag gccaagaccc      180

acgggcggg                                                              189


<210>  895
<211>  288
<212>  DNA
<213>  Homo sapiens

<400>  895
agccctcctt cagcaaagac caacacctct tcacccacat caactccacg catgctcggc       60

ttaacctgca gggctggaac aatgggggct gccctatcac agccatcgtt ctggagtacc      120

ggcccaaggg gacctgggcc tggcagggcc tccgggccaa cagctccggg gaggtgtttc      180

tgacggaact gcgagaggcc acgtggtacg agctgcgcat gagggcttgc aacagtgcgg      240

gctgcggcaa tgaaacagcc cagttcgcca ccctggacta cgatggca                   288


<210>  896
<211>  156
<212>  DNA
<213>  Homo sapiens

<400>  896
gcaccattcc acccatcaag tctgctcaag gtgaagggga tgatgtgaag aagctgttca       60

ccatcggctg ccctgtcatc ctggccacac tgggggtggc actgctcttc atcgtacgca      120

agaagaggaa ggagaaacgg ctgaagcgac tccgag                                156


<210>  897
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  897
atgcaaagag tttggcagaa atgttgataa g                                      31


<210>  898
<211>  119
<212>  DNA
<213>  Homo sapiens

<400>  898
caagaacaat agaagctttg acacccctgt gaaagggcca ccccagggcc cacggctaca       60

cattgacatc cccagggtcc agctgctcat cgaggacaaa gaaggcatca agcaactgg       119


<210>  899
<211>  153
<212>  DNA
<213>  Homo sapiens

<400>  899
gagatgacaa ggccaccatc cctgtgacag atgctgagtt cagccaagct gtcaacccac       60

agagcttctg tactggcgtc tccttgcacc acccaaccct catccagagc acaggacccc      120

tcatcgacat gtctgacatc cggccaggaa cca                                   153


<210>  900
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  900
atccagtgtc caggaagaat gtgaagtcag cccacagcac ccggaaccgg tactcaagcc       60

agtggaccct gaccaagtgc caggcctcca cacctgcccg caccctcacc tccgactggc      120

gcaccgtggg ctcccagcat ggtgtcacgg tcactgagag tgacagctac agtgccagcc      180

tgtcccagga cacag                                                       195


<210>  901
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  901
acaaaggaag gaacagcatg gtgtccactg agagtgcctc ttccacctac gaggagctgg       60

cccgggccta tgagcatgcc aagctggagg agcagctgca gcacgccaag tttgagatca      120

ccgagtgctt catctctgac agttcctctg accagatgac cacaggcacc aacgagaacg      180

ccgacagcat gacatccatg agcacaccct cagagcctgg catctgccgc tttaccgcct      240

caccacccaa gccccaggat gcggaccggg gcaaaaacgt ggctgtgccc atccctcacc      300

gggccaacaa ga                                                          312


<210>  902
<211>  1032
<212>  DNA
<213>  Homo sapiens

<400>  902
gtgactactg caacctgccc ctgtatgcca agtcagaggc cttctttcga aaggcagatg       60

gacgtgagcc ctgccccgtg gtcccacccc gtgaggcctc catccggaac ctggctcgaa      120

cctaccacac ccaggctcgc cacctgaccc tggaccctgc cagcaagtcc ttgggccttc      180

cccacccagg ggcccccgct gccgcctcca cagccacctt acctcagagg actctggcca      240

tgccagcccc cccagccggc acagcccccc cagcccccgg ccccacccct gctgagccac      300

ccaccgcccc cagcgctgcc cctccggccc ccagcaccga gcctccacga gccgggggcc      360

cacacaccaa aatggggggc tccagggact cgcttctcga gatgagcaca tcgggggtag      420

ggaggtctca gaagcagggg gccggggcct actccaaatc ctacaccctg gtgtagggcc      480

cgcaggaaga gcagccacgc ctggaccgcg ccgcgccgca gccccacacg ccagctcggc      540

tgtttttctg cattatttat attcaactga cagacaaaaa ccaaccaacg acaaaacaaa      600

aacccccaat catgaacgcc tgtacataga actcttttgt acaaatgaaa ctattttctt      660

cttctccatg aagccagggc acaaagaatt tgacagtaca agtcaaatcc cccaccccac      720

aaaatatgtg tggagatata tatacatata tagacagaca ggaacgcgtc cacgagctat      780

atatctatat atttctctca ccctattttg agacagaggc acaaagactc agcaattttt      840

ttccctcctc ctcaccttcc ccccagtcta ggtggttttg acaaagacca aaatcccaac      900

tcagagacac tgcatgcgat tttactgttc caagaaaacc aggagttgct tcaatttgca      960

gatgcttatg tgttaatacc tttttctatg aaaaaagacc cagcgccgtg tgcaataaag     1020

gttatgtttc ta                                                         1032


<210>  903
<211>  6855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full mRNA polynucleotide sequence of DSCAML1

<400>  903
agccgagcgc tgggctgagg agcagagaga gcggggcgcc gagtgcgggc ggctgggagc       60

gcgctgagcg ggggagaggc gctgccgcac ggccggccac aggaccacct ccccggagaa      120

tagggcctct ttatggcatg tggctggtaa ctttcctcct gctcctggac tctttacaca      180

aagcccgccc tgaagatgtt ggcaccagcc tctactttgt aaatgactcc ttgcagcagg      240

tgaccttttc cagctccgtg ggggtggtgg tgccctgccc ggccgcgggc tcccccagcg      300

cggcccttcg atggtacctg gccacagggg acgacatcta cgacgtgccg cacatccggc      360

acgtccacgc caacgggacg ctgcagctct accccttctc cccctccgcc ttcaatagct      420

ttatccacga caatgactac ttctgcaccg cggagaacgc tgccggcaag atccggagcc      480

ccaacatccg cgtcaaagca gttttcaggg aaccctacac cgtccgggtg gaggatcaaa      540

ggtcaatgcg tggcaacgtg gccgtcttca agtgcctcat cccctcttca gtgcaggaat      600

atgttagcgt tgtatcttgg gagaaagaca cagtctccat catcccagaa cacaggtttt      660

ttattaccta ccacggcggg ctgtacatct ctgacgtaca gaaggaggac gccctctcca      720

cctatcgctg catcaccaag cacaagtata gcggggagac ccggcagagc aatggggcac      780

gcctctctgt gacagaccct gctgagtcga tccccaccat cctggatggc ttccactccc      840

aggaagtgtg ggccggccac accgtggagc tgccctgcac cgcctcgggc taccctatcc      900

ccgccatccg ctggctcaag gatggccggc ccctcccggc tgacagccgc tggaccaagc      960

gcatcacagg gctgaccatc agcgacttgc ggaccgagga cagcggcacc tacatttgtg     1020

aggtcaccaa caccttcggt tcggcagagg ccacaggcat cctcatggtc attgatcccc     1080

ttcatgtgac cctgacacca aagaagctga agaccggcat tggcagcacg gtcatcctct     1140

cctgtgccct gacgggctcc ccagagttca ccatccgctg gtatcgcaac acggagctgg     1200

tgctgcctga cgaggccatc tccatccgcg ggctcagcaa cgagacgctg ctcatcacct     1260

cggcccagaa gagccattcc ggggcctacc agtgcttcgc tacccgcaag gcccagaccg     1320

cccaggactt tgccatcatt gcacttgagg atggcacgcc ccgcatcgtc tcgtccttca     1380

gcgagaaggt ggtcaacccc ggggagcagt tctcactgat gtgtgcggcc aagggcgccc     1440

cgccccccac ggtcacctgg gccctcgacg atgagcccat cgtgcgggat ggcagccacc     1500

gcaccaacca gtacaccatg tcggacggca ccaccatcag ccacatgaac gtcacaggcc     1560

cccagatccg cgacgggggc gtgtaccggt gcacagcgcg gaacttggtg ggcagtgctg     1620

aatatcaggc gcgaataaac gtaagaggcc cacccagcat ccgggctatg cggaacatca     1680

cagcagtcgc cgggcgggac acccttatca actgcagggt catcggctat ccctactact     1740

ccatcaagtg gtacaaggat gccctgctgc tgccagacaa ccaccgccag gtggtgtttg     1800

agaatgggac cctcaagctg actgacgtgc agaagggcat ggatgagggg gagtacctgt     1860

gcagtgtcct catccagccc cagctctcca tcagccagag cgttcacgta gccgtcaaag     1920

tgccccctct gatccagccc ttcgaattcc cacccgcctc catcggccag ctgctctaca     1980

ttccctgtgt ggtgtcctcg ggggacatgc ccatccgtat cacctggagg aaggacggac     2040

aggtgatcat ctcaggctcg ggcgtgacca tcgagagcaa ggaattcatg agctccctgc     2100

agatctctag cgtctccctc aagcacaacg gcaactatac atgcatcgcc agcaacgcag     2160

ccgccaccgt gagccgggag cgccagctca tcgtgcgtgt gccccctcga tttgtggtgc     2220

aacccaacaa ccaggatggc atctacggca aagctggtgt gctcaactgc tcggtggacg     2280

gctacccccc acccaaggtc atgtggaagc atgccaaggg gagcgggaac ccccagcagt     2340

accaccctgt gcccctcact ggccgcatcc agatcctgcc caacagctcg ctgctgatcc     2400

gccacgtcct agaagaggac atcggctact acctctgcca ggccagcaac ggcgtaggca     2460

ccgacatcag caagtccatg ttcctcacag tcaagatccc ggccatgatc acttcccacc     2520

ccaacaccac catcgccatc aagggccatg cgaaggagct aaactgcacg gcacggggtg     2580

agcggcccat catcatccgc tgggagaagg gggacacagt catcgaccct gaccgcgtca     2640

tgcggtatgc catcgccacc aaggacaacg gcgacgaggt cgtctccaca ctgaagctca     2700

agcccgctga ccgtggggac tctgtgttct tcagctgcca tgccatcaac tcgtatgggg     2760

aggaccgggg cttgatccaa ctcactgtgc aagagccccc cgacccccca gagctggaga     2820

tccgggaggt gaaggcccgg agcatgaacc tgcgctggac ccagcgattc gacgggaaca     2880

gcatcatcac gggcttcgac attgaataca agaacaaatc agattcctgg gacttcaagc     2940

agtccacacg caacatctcc cccaccatca accaggccaa cattgtggac ttgcacccgg     3000

catctgtgta cagcatccgc atgtactctt tcaacaagat tggccgcagt gaaccaagca     3060

aggagctcac catcagcact gaggaggccg ctcccgatgg gccccccatg gatgttacct     3120

tgcagccagt gacctcacag agcatccagg tgacctggaa ggcacccaag aaggagctgc     3180

agaacggtgt catccggggc taccagattg gctacagaga gaacagcccc ggcagcaacg     3240

ggcagtacag catcgtggag atgaaggcca cgggggacag cgaggtctac accctggaca     3300

acctcaagaa gttcgcccag tatggggtgg tggtccaagc cttcaatcgg gctggcacgg     3360

ggccctcttc cagcgagatc aatgccacca ctctggagga tgtgcccagc cagccccctg     3420

agaacgtccg ggccctgtcc atcacttctg acgtggccgt catctcctgg tcagagcccc     3480

cgcgcagcac cctcaatggc gtcctcaaag gctatcgggt catcttctgg tccctctatg     3540

ttgatgggga gtggggcgag atgcagaaca tcaccaccac gcgggagcgg gtggagctgc     3600

ggggcatgga gaagttcacc aactacagcg tccaggtgct ggcctacacc caggctgggg     3660

acggcgtacg cagcagtgtg ctctacatcc agaccaagga ggacgttcca ggtccccctg     3720

ctggcatcaa agctgtccct tcatcagcta gcagtgtggt tgtgtcttgg ctccccccta     3780

ccaagcccaa cggggtgatc cgcaagtaca ccatcttctg ttccagcccc gggtctggcc     3840

agccggctcc cagcgagtac gagacgagtc cagagcagct cttctaccgg atcgcccacc     3900

taaaccgcgg tcagcagtat ctgctgtggg tggccgccgt cacctctgcc ggccggggca     3960

acagcagcga gaaggtgacc atcgagcctg ctggcaaggc cccagcaaag atcatctcct     4020

ttgggggcac cgtgacaaca ccttggatga aagatgttcg gctgccttgc aattcagtgg     4080

gagatccagc ccctgctgtg aagtggacca aggacagtga agactcggcc attccagtgt     4140

ccatggatgg gcaccggctc atccacacca atggcacact gctgctgcgt gcagtgaagg     4200

ctgaggactc tggctactac acgtgcacgg ccaccaacac tggtggcttt gacaccatca     4260

tcgtcaacct tctggtgcaa gttcccccgg accagccccg cctcactgtc tccaaaacct     4320

cagcttcgtc catcaccctg acctggattc caggtgacaa tgggggcagc tccatccgag     4380

gcttcgtgct acagtactcg gtggacaaca gcgaggagtg gaaggatgtg ttcatcagct     4440

ccagcgagcg ctccttcaag ctggacagcc tcaagtgtgg cacgtggtac aaggtgaagc     4500

tggcagccaa gaacagcgtg ggctctgggc gcatcagcga gatcatcgag gccaagaccc     4560

acgggcggga gccctccttc agcaaagacc aacacctctt cacccacatc aactccacgc     4620

atgctcggct taacctgcag ggctggaaca atgggggctg ccctatcaca gccatcgttc     4680

tggagtaccg gcccaagggg acctgggcct ggcagggcct ccgggccaac agctccgggg     4740

aggtgtttct gacggaactg cgagaggcca cgtggtacga gctgcgcatg agggcttgca     4800

acagtgcggg ctgcggcaat gaaacagccc agttcgccac cctggactac gatggcagca     4860

ccattccacc catcaagtct gctcaaggtg aaggggatga tgtgaagaag ctgttcacca     4920

tcggctgccc tgtcatcctg gccacactgg gggtggcact gctcttcatc gtacgcaaga     4980

agaggaagga gaaacggctg aagcgactcc gagatgcaaa gagtttggca gaaatgttga     5040

taagcaagaa caatagaagc tttgacaccc ctgtgaaagg gccaccccag ggcccacggc     5100

tacacattga catccccagg gtccagctgc tcatcgagga caaagaaggc atcaagcaac     5160

tgggagatga caaggccacc atccctgtga cagatgctga gttcagccaa gctgtcaacc     5220

cacagagctt ctgtactggc gtctccttgc accacccaac cctcatccag agcacaggac     5280

ccctcatcga catgtctgac atccggccag gaaccaatcc agtgtccagg aagaatgtga     5340

agtcagccca cagcacccgg aaccggtact caagccagtg gaccctgacc aagtgccagg     5400

cctccacacc tgcccgcacc ctcacctccg actggcgcac cgtgggctcc cagcatggtg     5460

tcacggtcac tgagagtgac agctacagtg ccagcctgtc ccaggacaca gacaaaggaa     5520

ggaacagcat ggtgtccact gagagtgcct cttccaccta cgaggagctg gcccgggcct     5580

atgagcatgc caagctggag gagcagctgc agcacgccaa gtttgagatc accgagtgct     5640

tcatctctga cagttcctct gaccagatga ccacaggcac caacgagaac gccgacagca     5700

tgacatccat gagcacaccc tcagagcctg gcatctgccg ctttaccgcc tcaccaccca     5760

agccccagga tgcggaccgg ggcaaaaacg tggctgtgcc catccctcac cgggccaaca     5820

agagtgacta ctgcaacctg cccctgtatg ccaagtcaga ggccttcttt cgaaaggcag     5880

atggacgtga gccctgcccc gtggtcccac cccgtgaggc ctccatccgg aacctggctc     5940

gaacctacca cacccaggct cgccacctga ccctggaccc tgccagcaag tccttgggcc     6000

ttccccaccc aggggccccc gctgccgcct ccacagccac cttacctcag aggactctgg     6060

ccatgccagc ccccccagcc ggcacagccc ccccagcccc cggccccacc cctgctgagc     6120

cacccaccgc ccccagcgct gcccctccgg cccccagcac cgagcctcca cgagccgggg     6180

gcccacacac caaaatgggg ggctccaggg actcgcttct cgagatgagc acatcggggg     6240

tagggaggtc tcagaagcag ggggccgggg cctactccaa atcctacacc ctggtgtagg     6300

gcccgcagga agagcagcca cgcctggacc gcgccgcgcc gcagccccac acgccagctc     6360

ggctgttttt ctgcattatt tatattcaac tgacagacaa aaaccaacca acgacaaaac     6420

aaaaaccccc aatcatgaac gcctgtacat agaactcttt tgtacaaatg aaactatttt     6480

cttcttctcc atgaagccag ggcacaaaga atttgacagt acaagtcaaa tcccccaccc     6540

cacaaaatat gtgtggagat atatatacat atatagacag acaggaacgc gtccacgagc     6600

tatatatcta tatatttctc tcaccctatt ttgagacaga ggcacaaaga ctcagcaatt     6660

tttttccctc ctcctcacct tccccccagt ctaggtggtt ttgacaaaga ccaaaatccc     6720

aactcagaga cactgcatgc gattttactg ttccaagaaa accaggagtt gcttcaattt     6780

gcagatgctt atgtgttaat acctttttct atgaaaaaag acccagcgcc gtgtgcaata     6840

aaggttatgt ttcta                                                      6855


<210>  904
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  904

Met Trp Leu Val Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys 
1               5                   10                  15  


<210>  905
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  905

Arg Pro Glu Asp Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser Leu 
1               5                   10                  15      


Gln Gln Val Thr Phe Ser Ser Ser Val Gly Val Val Val Pro Cys Pro 
            20                  25                  30          


Ala Ala Gly Ser Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr Gly 
        35                  40                  45              


Asp Asp Ile Tyr Asp Val Pro His Ile Arg His Val His Ala Asn Gly 
    50                  55                  60                  


Thr Leu Gln Leu Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe Ile 
65                  70                  75                  80  


His Asp Asn Asp Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys Ile 
                85                  90                  95      


Arg Ser Pro Asn Ile Arg Val Lys Ala 
            100                 105 


<210>  906
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  906

Phe Arg Glu Pro Tyr Thr Val Arg Val Glu Asp Gln Arg Ser Met Arg 
1               5                   10                  15      


Gly Asn Val Ala Val Phe Lys Cys Leu Ile Pro Ser Ser Val Gln Glu 
            20                  25                  30          


Tyr Val Ser Val Val Ser Trp Glu Lys Asp Thr Val Ser Ile Ile Pro 
        35                  40                  45              


<210>  907
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  907

His Arg Phe Phe Ile Thr Tyr His Gly Gly Leu Tyr Ile Ser Asp Val 
1               5                   10                  15      


Gln Lys Glu Asp Ala Leu Ser Thr Tyr Arg Cys Ile Thr Lys His Lys 
            20                  25                  30          


Tyr Ser Gly Glu Thr Arg Gln Ser Asn Gly Ala Arg Leu Ser Val Thr 
        35                  40                  45              


<210>  908
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  908

Pro Ala Glu Ser Ile Pro Thr Ile Leu Asp Gly Phe His Ser Gln Glu 
1               5                   10                  15      


Val Trp Ala Gly His Thr Val Glu Leu Pro Cys Thr Ala Ser Gly Tyr 
            20                  25                  30          


Pro Ile Pro Ala Ile Arg Trp Leu Lys Asp Gly Arg Pro Leu Pro Ala 
        35                  40                  45              


Asp Ser Arg Trp Thr Lys Arg Ile Thr Gly Leu Thr Ile Ser Asp Leu 
    50                  55                  60                  


Arg Thr Glu Asp Ser Gly Thr Tyr Ile Cys Glu Val Thr Asn Thr Phe 
65                  70                  75                  80  


Gly Ser Ala Glu Ala Thr Gly Ile Leu Met Val Ile 
                85                  90          


<210>  909
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  909

Pro Leu His Val Thr Leu Thr Pro Lys Lys Leu Lys Thr Gly Ile Gly 
1               5                   10                  15      


Ser Thr Val Ile Leu Ser Cys Ala Leu Thr Gly Ser Pro Glu Phe Thr 
            20                  25                  30          


Ile Arg Trp Tyr Arg Asn Thr Glu Leu Val Leu Pro Asp Glu Ala Ile 
        35                  40                  45              


Ser Ile Arg Gly Leu Ser Asn Glu Thr Leu Leu Ile Thr Ser Ala Gln 
    50                  55                  60                  


Lys Ser His Ser Gly Ala Tyr Gln Cys Phe Ala Thr Arg Lys Ala Gln 
65                  70                  75                  80  


Thr Ala Gln Asp Phe Ala Ile Ile Ala Leu Glu 
                85                  90      


<210>  910
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  910

Gly Thr Pro Arg Ile Val Ser Ser Phe Ser Glu Lys Val Val Asn Pro 
1               5                   10                  15      


Gly Glu Gln Phe Ser Leu Met Cys Ala Ala Lys Gly Ala Pro Pro Pro 
            20                  25                  30          


Thr Val Thr Trp Ala Leu Asp Asp Glu Pro Ile Val Arg Asp Gly Ser 
        35                  40                  45              


His Arg Thr Asn Gln Tyr Thr Met Ser Asp Gly Thr Thr Ile Ser His 
    50                  55                  60                  


Met Asn Val Thr Gly Pro Gln Ile Arg Asp Gly Gly Val Tyr Arg Cys 
65                  70                  75                  80  


Thr Ala Arg Asn Leu Val Gly Ser Ala Glu Tyr Gln Ala Arg Ile Asn 
                85                  90                  95      


Val Arg 
        


<210>  911
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  911

Pro Pro Ser Ile Arg Ala Met Arg Asn Ile Thr Ala Val Ala Gly Arg 
1               5                   10                  15      


Asp Thr Leu Ile Asn Cys Arg Val Ile Gly Tyr Pro Tyr Tyr Ser Ile 
            20                  25                  30          


Lys Trp Tyr Lys Asp Ala Leu Leu Leu Pro Asp Asn His Arg Gln Val 
        35                  40                  45              


Val Phe Glu Asn Gly Thr Leu Lys Leu Thr Asp Val Gln Lys Gly Met 
    50                  55                  60                  


Asp Glu Gly Glu Tyr Leu Cys Ser Val Leu Ile Gln Pro Gln Leu Ser 
65                  70                  75                  80  


Ile Ser Gln Ser Val His Val Ala Val Lys 
                85                  90  


<210>  912
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  912

Pro Pro Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala Ser Ile Gly Gln 
1               5                   10                  15      


Leu Leu Tyr Ile Pro Cys Val Val Ser Ser Gly Asp Met Pro Ile Arg 
            20                  25                  30          


Ile Thr Trp Arg Lys Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val 
        35                  40                  45              


Thr Ile Glu Ser Lys Glu Phe Met Ser Ser Leu Gln Ile Ser Ser Val 
    50                  55                  60                  


Ser Leu Lys His Asn Gly Asn Tyr Thr Cys Ile Ala Ser Asn Ala Ala 
65                  70                  75                  80  


Ala Thr Val Ser Arg Glu Arg Gln Leu Ile Val Arg 
                85                  90          


<210>  913
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  913

Pro Pro Arg Phe Val Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr Gly 
1               5                   10                  15      


Lys Ala Gly Val Leu Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro Lys 
            20                  25                  30          


Val Met Trp Lys His Ala Lys 
        35                  


<210>  914
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  914

Ser Gly Asn Pro Gln Gln Tyr His Pro Val Pro Leu Thr Gly Arg Ile 
1               5                   10                  15      


Gln Ile Leu Pro Asn Ser Ser Leu Leu Ile Arg His Val Leu Glu Glu 
            20                  25                  30          


Asp Ile Gly Tyr Tyr Leu Cys Gln Ala Ser Asn Gly Val Gly Thr Asp 
        35                  40                  45              


Ile Ser Lys Ser Met Phe Leu Thr Val Lys 
    50                  55              


<210>  915
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  915

Pro Ala Met Ile Thr Ser His Pro Asn Thr Thr Ile Ala Ile Lys Gly 
1               5                   10                  15      


His Ala Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu Arg Pro Ile Ile 
            20                  25                  30          


Ile Arg Trp Glu Lys Gly Asp Thr Val Ile Asp Pro Asp Arg Val Met 
        35                  40                  45              


Arg Tyr Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu Val Val Ser Thr 
    50                  55                  60                  


Leu Lys 
65      


<210>  916
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  916

Leu Lys Pro Ala Asp Arg Gly Asp Ser Val Phe Phe Ser Cys His Ala 
1               5                   10                  15      


Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu Ile Gln Leu Thr Val Gln 
            20                  25                  30          


<210>  917
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  917

Pro Pro Asp Pro Pro Glu Leu Glu Ile Arg Glu Val Lys Ala Arg Ser 
1               5                   10                  15      


Met Asn Leu Arg Trp Thr Gln Arg Phe Asp Gly Asn Ser Ile Ile Thr 
            20                  25                  30          


Gly Phe Asp Ile Glu Tyr Lys Asn Lys Ser 
        35                  40          


<210>  918
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  918

Ser Trp Asp Phe Lys Gln Ser Thr Arg Asn Ile Ser Pro Thr Ile Asn 
1               5                   10                  15      


Gln Ala Asn Ile Val Asp Leu His Pro Ala Ser Val Tyr Ser Ile Arg 
            20                  25                  30          


Met Tyr Ser Phe Asn Lys Ile Gly Arg Ser Glu Pro Ser Lys Glu Leu 
        35                  40                  45              


Thr Ile Ser Thr Glu Glu Ala 
    50                  55  


<210>  919
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  919

Pro Asp Gly Pro Pro Met Asp Val Thr Leu Gln Pro Val Thr Ser Gln 
1               5                   10                  15      


Ser Ile Gln Val Thr Trp Lys 
            20              


<210>  920
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  920

Ala Pro Lys Lys Glu Leu Gln Asn Gly Val Ile Arg Gly Tyr Gln Ile 
1               5                   10                  15      


Gly Tyr Arg Glu Asn Ser Pro Gly Ser Asn Gly Gln Tyr Ser Ile Val 
            20                  25                  30          


Glu Met Lys Ala Thr Gly Asp Ser Glu Val Tyr Thr Leu Asp Asn Leu 
        35                  40                  45              


Lys Lys Phe Ala Gln Tyr Gly Val Val Val Gln Ala Phe Asn Arg Ala 
    50                  55                  60                  


Gly Thr Gly Pro Ser Ser Ser Glu Ile Asn Ala Thr Thr Leu Glu Asp 
65                  70                  75                  80  


<210>  921
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  921

Pro Ser Gln Pro Pro Glu Asn Val Arg Ala Leu Ser Ile Thr Ser Asp 
1               5                   10                  15      


Val Ala Val Ile Ser Trp Ser Glu Pro Pro Arg Ser Thr Leu Asn Gly 
            20                  25                  30          


Val Leu Lys Gly Tyr Arg Val Ile Phe Trp Ser Leu Tyr Val Asp Gly 
        35                  40                  45              


<210>  922
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  922

Trp Gly Glu Met Gln Asn Ile Thr Thr Thr Arg Glu Arg Val Glu Leu 
1               5                   10                  15      


Arg Gly Met Glu Lys Phe Thr Asn Tyr Ser Val Gln Val Leu Ala Tyr 
            20                  25                  30          


Thr Gln Ala Gly Asp Gly Val Arg Ser Ser Val Leu Tyr Ile Gln Thr 
        35                  40                  45              


Lys Glu Asp 
    50      


<210>  923
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  923

Pro Gly Pro Pro Ala Gly Ile Lys Ala Val Pro Ser Ser Ala Ser Ser 
1               5                   10                  15      


Val Val Val Ser Trp Leu Pro Pro Thr Lys Pro Asn Gly Val Ile Arg 
            20                  25                  30          


Lys Tyr Thr Ile Phe Cys Ser Ser Pro Gly Ser Gly Gln Pro 
        35                  40                  45      


<210>  924
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  924

Ala Pro Ser Glu Tyr Glu Thr Ser Pro Glu Gln Leu Phe Tyr Arg Ile 
1               5                   10                  15      


Ala His Leu Asn Arg Gly Gln Gln Tyr Leu Leu Trp Val Ala Ala Val 
            20                  25                  30          


Thr Ser Ala Gly Arg Gly Asn Ser Ser Glu Lys Val Thr Ile Glu Pro 
        35                  40                  45              


Ala Gly Lys 
    50      


<210>  925
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  925

Pro Ala Lys Ile Ile Ser Phe Gly Gly Thr Val Thr Thr Pro Trp Met 
1               5                   10                  15      


Lys Asp Val Arg Leu Pro Cys Asn Ser Val Gly Asp Pro Ala Pro Ala 
            20                  25                  30          


Val Lys Trp Thr Lys Asp 
        35              


<210>  926
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  926

Glu Asp Ser Ala Ile Pro Val Ser Met Asp Gly His Arg Leu Ile His 
1               5                   10                  15      


Thr Asn Gly Thr Leu Leu Leu Arg Ala Val Lys Ala Glu Asp Ser Gly 
            20                  25                  30          


Tyr Tyr Thr Cys Thr Ala Thr Asn Thr Gly Gly Phe Asp Thr Ile Ile 
        35                  40                  45              


Val Asn Leu Leu Val Gln 
    50                  


<210>  927
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  927

Pro Pro Asp Gln Pro Arg Leu Thr Val Ser Lys Thr Ser Ala Ser Ser 
1               5                   10                  15      


Ile Thr Leu Thr Trp Ile Pro Gly Asp Asn Gly Gly Ser Ser Ile Arg 
            20                  25                  30          


<210>  928
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  928

Phe Val Leu Gln Tyr Ser Val Asp Asn Ser Glu Glu Trp Lys Asp Val 
1               5                   10                  15      


Phe Ile Ser Ser Ser Glu Arg Ser Phe Lys Leu Asp Ser Leu Lys Cys 
            20                  25                  30          


Gly Thr Trp Tyr Lys Val Lys Leu Ala Ala Lys Asn Ser Val Gly Ser 
        35                  40                  45              


Gly Arg Ile Ser Glu Ile Ile Glu Ala Lys Thr His Gly Arg 
    50                  55                  60          


<210>  929
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  929

Pro Ser Phe Ser Lys Asp Gln His Leu Phe Thr His Ile Asn Ser Thr 
1               5                   10                  15      


His Ala Arg Leu Asn Leu Gln Gly Trp Asn Asn Gly Gly Cys Pro Ile 
            20                  25                  30          


Thr Ala Ile Val Leu Glu Tyr Arg Pro Lys Gly Thr Trp Ala Trp Gln 
        35                  40                  45              


Gly Leu Arg Ala Asn Ser Ser Gly Glu Val Phe Leu Thr Glu Leu Arg 
    50                  55                  60                  


Glu Ala Thr Trp Tyr Glu Leu Arg Met Arg Ala Cys Asn Ser Ala Gly 
65                  70                  75                  80  


Cys Gly Asn Glu Thr Ala Gln Phe Ala Thr Leu Asp Tyr Asp Gly 
                85                  90                  95  


<210>  930
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  930

Thr Ile Pro Pro Ile Lys Ser Ala Gln Gly Glu Gly Asp Asp Val Lys 
1               5                   10                  15      


Lys Leu Phe Thr Ile Gly Cys Pro Val Ile Leu Ala Thr Leu Gly Val 
            20                  25                  30          


Ala Leu Leu Phe Ile Val Arg Lys Lys Arg Lys Glu Lys Arg Leu Lys 
        35                  40                  45              


Arg Leu Arg 
    50      


<210>  931
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  931

Ala Lys Ser Leu Ala Glu Met Leu Ile 
1               5                   


<210>  932
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  932

Lys Asn Asn Arg Ser Phe Asp Thr Pro Val Lys Gly Pro Pro Gln Gly 
1               5                   10                  15      


Pro Arg Leu His Ile Asp Ile Pro Arg Val Gln Leu Leu Ile Glu Asp 
            20                  25                  30          


Lys Glu Gly Ile Lys Gln Leu 
        35                  


<210>  933
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  933

Asp Asp Lys Ala Thr Ile Pro Val Thr Asp Ala Glu Phe Ser Gln Ala 
1               5                   10                  15      


Val Asn Pro Gln Ser Phe Cys Thr Gly Val Ser Leu His His Pro Thr 
            20                  25                  30          


Leu Ile Gln Ser Thr Gly Pro Leu Ile Asp Met Ser Asp Ile Arg Pro 
        35                  40                  45              


Gly Thr 
    50  


<210>  934
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  934

Pro Val Ser Arg Lys Asn Val Lys Ser Ala His Ser Thr Arg Asn Arg 
1               5                   10                  15      


Tyr Ser Ser Gln Trp Thr Leu Thr Lys Cys Gln Ala Ser Thr Pro Ala 
            20                  25                  30          


Arg Thr Leu Thr Ser Asp Trp Arg Thr Val Gly Ser Gln His Gly Val 
        35                  40                  45              


Thr Val Thr Glu Ser Asp Ser Tyr Ser Ala Ser Leu Ser Gln Asp Thr 
    50                  55                  60                  


<210>  935
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  935

Lys Gly Arg Asn Ser Met Val Ser Thr Glu Ser Ala Ser Ser Thr Tyr 
1               5                   10                  15      


Glu Glu Leu Ala Arg Ala Tyr Glu His Ala Lys Leu Glu Glu Gln Leu 
            20                  25                  30          


Gln His Ala Lys Phe Glu Ile Thr Glu Cys Phe Ile Ser Asp Ser Ser 
        35                  40                  45              


Ser Asp Gln Met Thr Thr Gly Thr Asn Glu Asn Ala Asp Ser Met Thr 
    50                  55                  60                  


Ser Met Ser Thr Pro Ser Glu Pro Gly Ile Cys Arg Phe Thr Ala Ser 
65                  70                  75                  80  


Pro Pro Lys Pro Gln Asp Ala Asp Arg Gly Lys Asn Val Ala Val Pro 
                85                  90                  95      


Ile Pro His Arg Ala Asn Lys 
            100             


<210>  936
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  936

Asp Tyr Cys Asn Leu Pro Leu Tyr Ala Lys Ser Glu Ala Phe Phe Arg 
1               5                   10                  15      


Lys Ala Asp Gly Arg Glu Pro Cys Pro Val Val Pro Pro Arg Glu Ala 
            20                  25                  30          


Ser Ile Arg Asn Leu Ala Arg Thr Tyr His Thr Gln Ala Arg His Leu 
        35                  40                  45              


Thr Leu Asp Pro Ala Ser Lys Ser Leu Gly Leu Pro His Pro Gly Ala 
    50                  55                  60                  


Pro Ala Ala Ala Ser Thr Ala Thr Leu Pro Gln Arg Thr Leu Ala Met 
65                  70                  75                  80  


Pro Ala Pro Pro Ala Gly Thr Ala Pro Pro Ala Pro Gly Pro Thr Pro 
                85                  90                  95      


Ala Glu Pro Pro Thr Ala Pro Ser Ala Ala Pro Pro Ala Pro Ser Thr 
            100                 105                 110         


Glu Pro Pro Arg Ala Gly Gly Pro His Thr Lys Met Gly Gly Ser Arg 
        115                 120                 125             


Asp Ser Leu Leu Glu Met Ser Thr Ser Gly Val Gly Arg Ser Gln Lys 
    130                 135                 140                 


Gln Gly Ala Gly Ala Tyr Ser Lys Ser Tyr Thr Leu Val 
145                 150                 155         


<210>  937
<211>  2053
<212>  PRT
<213>  Homo sapiens

<400>  937

Met Trp Leu Val Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys Ala 
1               5                   10                  15      


Arg Pro Glu Asp Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser Leu 
            20                  25                  30          


Gln Gln Val Thr Phe Ser Ser Ser Val Gly Val Val Val Pro Cys Pro 
        35                  40                  45              


Ala Ala Gly Ser Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr Gly 
    50                  55                  60                  


Asp Asp Ile Tyr Asp Val Pro His Ile Arg His Val His Ala Asn Gly 
65                  70                  75                  80  


Thr Leu Gln Leu Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe Ile 
                85                  90                  95      


His Asp Asn Asp Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys Ile 
            100                 105                 110         


Arg Ser Pro Asn Ile Arg Val Lys Ala Val Phe Arg Glu Pro Tyr Thr 
        115                 120                 125             


Val Arg Val Glu Asp Gln Arg Ser Met Arg Gly Asn Val Ala Val Phe 
    130                 135                 140                 


Lys Cys Leu Ile Pro Ser Ser Val Gln Glu Tyr Val Ser Val Val Ser 
145                 150                 155                 160 


Trp Glu Lys Asp Thr Val Ser Ile Ile Pro Glu His Arg Phe Phe Ile 
                165                 170                 175     


Thr Tyr His Gly Gly Leu Tyr Ile Ser Asp Val Gln Lys Glu Asp Ala 
            180                 185                 190         


Leu Ser Thr Tyr Arg Cys Ile Thr Lys His Lys Tyr Ser Gly Glu Thr 
        195                 200                 205             


Arg Gln Ser Asn Gly Ala Arg Leu Ser Val Thr Asp Pro Ala Glu Ser 
    210                 215                 220                 


Ile Pro Thr Ile Leu Asp Gly Phe His Ser Gln Glu Val Trp Ala Gly 
225                 230                 235                 240 


His Thr Val Glu Leu Pro Cys Thr Ala Ser Gly Tyr Pro Ile Pro Ala 
                245                 250                 255     


Ile Arg Trp Leu Lys Asp Gly Arg Pro Leu Pro Ala Asp Ser Arg Trp 
            260                 265                 270         


Thr Lys Arg Ile Thr Gly Leu Thr Ile Ser Asp Leu Arg Thr Glu Asp 
        275                 280                 285             


Ser Gly Thr Tyr Ile Cys Glu Val Thr Asn Thr Phe Gly Ser Ala Glu 
    290                 295                 300                 


Ala Thr Gly Ile Leu Met Val Ile Asp Pro Leu His Val Thr Leu Thr 
305                 310                 315                 320 


Pro Lys Lys Leu Lys Thr Gly Ile Gly Ser Thr Val Ile Leu Ser Cys 
                325                 330                 335     


Ala Leu Thr Gly Ser Pro Glu Phe Thr Ile Arg Trp Tyr Arg Asn Thr 
            340                 345                 350         


Glu Leu Val Leu Pro Asp Glu Ala Ile Ser Ile Arg Gly Leu Ser Asn 
        355                 360                 365             


Glu Thr Leu Leu Ile Thr Ser Ala Gln Lys Ser His Ser Gly Ala Tyr 
    370                 375                 380                 


Gln Cys Phe Ala Thr Arg Lys Ala Gln Thr Ala Gln Asp Phe Ala Ile 
385                 390                 395                 400 


Ile Ala Leu Glu Asp Gly Thr Pro Arg Ile Val Ser Ser Phe Ser Glu 
                405                 410                 415     


Lys Val Val Asn Pro Gly Glu Gln Phe Ser Leu Met Cys Ala Ala Lys 
            420                 425                 430         


Gly Ala Pro Pro Pro Thr Val Thr Trp Ala Leu Asp Asp Glu Pro Ile 
        435                 440                 445             


Val Arg Asp Gly Ser His Arg Thr Asn Gln Tyr Thr Met Ser Asp Gly 
    450                 455                 460                 


Thr Thr Ile Ser His Met Asn Val Thr Gly Pro Gln Ile Arg Asp Gly 
465                 470                 475                 480 


Gly Val Tyr Arg Cys Thr Ala Arg Asn Leu Val Gly Ser Ala Glu Tyr 
                485                 490                 495     


Gln Ala Arg Ile Asn Val Arg Gly Pro Pro Ser Ile Arg Ala Met Arg 
            500                 505                 510         


Asn Ile Thr Ala Val Ala Gly Arg Asp Thr Leu Ile Asn Cys Arg Val 
        515                 520                 525             


Ile Gly Tyr Pro Tyr Tyr Ser Ile Lys Trp Tyr Lys Asp Ala Leu Leu 
    530                 535                 540                 


Leu Pro Asp Asn His Arg Gln Val Val Phe Glu Asn Gly Thr Leu Lys 
545                 550                 555                 560 


Leu Thr Asp Val Gln Lys Gly Met Asp Glu Gly Glu Tyr Leu Cys Ser 
                565                 570                 575     


Val Leu Ile Gln Pro Gln Leu Ser Ile Ser Gln Ser Val His Val Ala 
            580                 585                 590         


Val Lys Val Pro Pro Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala Ser 
        595                 600                 605             


Ile Gly Gln Leu Leu Tyr Ile Pro Cys Val Val Ser Ser Gly Asp Met 
    610                 615                 620                 


Pro Ile Arg Ile Thr Trp Arg Lys Asp Gly Gln Val Ile Ile Ser Gly 
625                 630                 635                 640 


Ser Gly Val Thr Ile Glu Ser Lys Glu Phe Met Ser Ser Leu Gln Ile 
                645                 650                 655     


Ser Ser Val Ser Leu Lys His Asn Gly Asn Tyr Thr Cys Ile Ala Ser 
            660                 665                 670         


Asn Ala Ala Ala Thr Val Ser Arg Glu Arg Gln Leu Ile Val Arg Val 
        675                 680                 685             


Pro Pro Arg Phe Val Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr Gly 
    690                 695                 700                 


Lys Ala Gly Val Leu Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro Lys 
705                 710                 715                 720 


Val Met Trp Lys His Ala Lys Gly Ser Gly Asn Pro Gln Gln Tyr His 
                725                 730                 735     


Pro Val Pro Leu Thr Gly Arg Ile Gln Ile Leu Pro Asn Ser Ser Leu 
            740                 745                 750         


Leu Ile Arg His Val Leu Glu Glu Asp Ile Gly Tyr Tyr Leu Cys Gln 
        755                 760                 765             


Ala Ser Asn Gly Val Gly Thr Asp Ile Ser Lys Ser Met Phe Leu Thr 
    770                 775                 780                 


Val Lys Ile Pro Ala Met Ile Thr Ser His Pro Asn Thr Thr Ile Ala 
785                 790                 795                 800 


Ile Lys Gly His Ala Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu Arg 
                805                 810                 815     


Pro Ile Ile Ile Arg Trp Glu Lys Gly Asp Thr Val Ile Asp Pro Asp 
            820                 825                 830         


Arg Val Met Arg Tyr Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu Val 
        835                 840                 845             


Val Ser Thr Leu Lys Leu Lys Pro Ala Asp Arg Gly Asp Ser Val Phe 
    850                 855                 860                 


Phe Ser Cys His Ala Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu Ile 
865                 870                 875                 880 


Gln Leu Thr Val Gln Glu Pro Pro Asp Pro Pro Glu Leu Glu Ile Arg 
                885                 890                 895     


Glu Val Lys Ala Arg Ser Met Asn Leu Arg Trp Thr Gln Arg Phe Asp 
            900                 905                 910         


Gly Asn Ser Ile Ile Thr Gly Phe Asp Ile Glu Tyr Lys Asn Lys Ser 
        915                 920                 925             


Asp Ser Trp Asp Phe Lys Gln Ser Thr Arg Asn Ile Ser Pro Thr Ile 
    930                 935                 940                 


Asn Gln Ala Asn Ile Val Asp Leu His Pro Ala Ser Val Tyr Ser Ile 
945                 950                 955                 960 


Arg Met Tyr Ser Phe Asn Lys Ile Gly Arg Ser Glu Pro Ser Lys Glu 
                965                 970                 975     


Leu Thr Ile Ser Thr Glu Glu Ala Ala Pro Asp Gly Pro Pro Met Asp 
            980                 985                 990         


Val Thr Leu Gln Pro Val Thr Ser  Gln Ser Ile Gln Val  Thr Trp Lys 
        995                 1000                 1005             


Ala Pro  Lys Lys Glu Leu Gln  Asn Gly Val Ile Arg  Gly Tyr Gln 
    1010                 1015                 1020             


Ile Gly  Tyr Arg Glu Asn Ser  Pro Gly Ser Asn Gly  Gln Tyr Ser 
    1025                 1030                 1035             


Ile Val  Glu Met Lys Ala Thr  Gly Asp Ser Glu Val  Tyr Thr Leu 
    1040                 1045                 1050             


Asp Asn  Leu Lys Lys Phe Ala  Gln Tyr Gly Val Val  Val Gln Ala 
    1055                 1060                 1065             


Phe Asn  Arg Ala Gly Thr Gly  Pro Ser Ser Ser Glu  Ile Asn Ala 
    1070                 1075                 1080             


Thr Thr  Leu Glu Asp Val Pro  Ser Gln Pro Pro Glu  Asn Val Arg 
    1085                 1090                 1095             


Ala Leu  Ser Ile Thr Ser Asp  Val Ala Val Ile Ser  Trp Ser Glu 
    1100                 1105                 1110             


Pro Pro  Arg Ser Thr Leu Asn  Gly Val Leu Lys Gly  Tyr Arg Val 
    1115                 1120                 1125             


Ile Phe  Trp Ser Leu Tyr Val  Asp Gly Glu Trp Gly  Glu Met Gln 
    1130                 1135                 1140             


Asn Ile  Thr Thr Thr Arg Glu  Arg Val Glu Leu Arg  Gly Met Glu 
    1145                 1150                 1155             


Lys Phe  Thr Asn Tyr Ser Val  Gln Val Leu Ala Tyr  Thr Gln Ala 
    1160                 1165                 1170             


Gly Asp  Gly Val Arg Ser Ser  Val Leu Tyr Ile Gln  Thr Lys Glu 
    1175                 1180                 1185             


Asp Val  Pro Gly Pro Pro Ala  Gly Ile Lys Ala Val  Pro Ser Ser 
    1190                 1195                 1200             


Ala Ser  Ser Val Val Val Ser  Trp Leu Pro Pro Thr  Lys Pro Asn 
    1205                 1210                 1215             


Gly Val  Ile Arg Lys Tyr Thr  Ile Phe Cys Ser Ser  Pro Gly Ser 
    1220                 1225                 1230             


Gly Gln  Pro Ala Pro Ser Glu  Tyr Glu Thr Ser Pro  Glu Gln Leu 
    1235                 1240                 1245             


Phe Tyr  Arg Ile Ala His Leu  Asn Arg Gly Gln Gln  Tyr Leu Leu 
    1250                 1255                 1260             


Trp Val  Ala Ala Val Thr Ser  Ala Gly Arg Gly Asn  Ser Ser Glu 
    1265                 1270                 1275             


Lys Val  Thr Ile Glu Pro Ala  Gly Lys Ala Pro Ala  Lys Ile Ile 
    1280                 1285                 1290             


Ser Phe  Gly Gly Thr Val Thr  Thr Pro Trp Met Lys  Asp Val Arg 
    1295                 1300                 1305             


Leu Pro  Cys Asn Ser Val Gly  Asp Pro Ala Pro Ala  Val Lys Trp 
    1310                 1315                 1320             


Thr Lys  Asp Ser Glu Asp Ser  Ala Ile Pro Val Ser  Met Asp Gly 
    1325                 1330                 1335             


His Arg  Leu Ile His Thr Asn  Gly Thr Leu Leu Leu  Arg Ala Val 
    1340                 1345                 1350             


Lys Ala  Glu Asp Ser Gly Tyr  Tyr Thr Cys Thr Ala  Thr Asn Thr 
    1355                 1360                 1365             


Gly Gly  Phe Asp Thr Ile Ile  Val Asn Leu Leu Val  Gln Val Pro 
    1370                 1375                 1380             


Pro Asp  Gln Pro Arg Leu Thr  Val Ser Lys Thr Ser  Ala Ser Ser 
    1385                 1390                 1395             


Ile Thr  Leu Thr Trp Ile Pro  Gly Asp Asn Gly Gly  Ser Ser Ile 
    1400                 1405                 1410             


Arg Gly  Phe Val Leu Gln Tyr  Ser Val Asp Asn Ser  Glu Glu Trp 
    1415                 1420                 1425             


Lys Asp  Val Phe Ile Ser Ser  Ser Glu Arg Ser Phe  Lys Leu Asp 
    1430                 1435                 1440             


Ser Leu  Lys Cys Gly Thr Trp  Tyr Lys Val Lys Leu  Ala Ala Lys 
    1445                 1450                 1455             


Asn Ser  Val Gly Ser Gly Arg  Ile Ser Glu Ile Ile  Glu Ala Lys 
    1460                 1465                 1470             


Thr His  Gly Arg Glu Pro Ser  Phe Ser Lys Asp Gln  His Leu Phe 
    1475                 1480                 1485             


Thr His  Ile Asn Ser Thr His  Ala Arg Leu Asn Leu  Gln Gly Trp 
    1490                 1495                 1500             


Asn Asn  Gly Gly Cys Pro Ile  Thr Ala Ile Val Leu  Glu Tyr Arg 
    1505                 1510                 1515             


Pro Lys  Gly Thr Trp Ala Trp  Gln Gly Leu Arg Ala  Asn Ser Ser 
    1520                 1525                 1530             


Gly Glu  Val Phe Leu Thr Glu  Leu Arg Glu Ala Thr  Trp Tyr Glu 
    1535                 1540                 1545             


Leu Arg  Met Arg Ala Cys Asn  Ser Ala Gly Cys Gly  Asn Glu Thr 
    1550                 1555                 1560             


Ala Gln  Phe Ala Thr Leu Asp  Tyr Asp Gly Ser Thr  Ile Pro Pro 
    1565                 1570                 1575             


Ile Lys  Ser Ala Gln Gly Glu  Gly Asp Asp Val Lys  Lys Leu Phe 
    1580                 1585                 1590             


Thr Ile  Gly Cys Pro Val Ile  Leu Ala Thr Leu Gly  Val Ala Leu 
    1595                 1600                 1605             


Leu Phe  Ile Val Arg Lys Lys  Arg Lys Glu Lys Arg  Leu Lys Arg 
    1610                 1615                 1620             


Leu Arg  Asp Ala Lys Ser Leu  Ala Glu Met Leu Ile  Ser Lys Asn 
    1625                 1630                 1635             


Asn Arg  Ser Phe Asp Thr Pro  Val Lys Gly Pro Pro  Gln Gly Pro 
    1640                 1645                 1650             


Arg Leu  His Ile Asp Ile Pro  Arg Val Gln Leu Leu  Ile Glu Asp 
    1655                 1660                 1665             


Lys Glu  Gly Ile Lys Gln Leu  Gly Asp Asp Lys Ala  Thr Ile Pro 
    1670                 1675                 1680             


Val Thr  Asp Ala Glu Phe Ser  Gln Ala Val Asn Pro  Gln Ser Phe 
    1685                 1690                 1695             


Cys Thr  Gly Val Ser Leu His  His Pro Thr Leu Ile  Gln Ser Thr 
    1700                 1705                 1710             


Gly Pro  Leu Ile Asp Met Ser  Asp Ile Arg Pro Gly  Thr Asn Pro 
    1715                 1720                 1725             


Val Ser  Arg Lys Asn Val Lys  Ser Ala His Ser Thr  Arg Asn Arg 
    1730                 1735                 1740             


Tyr Ser  Ser Gln Trp Thr Leu  Thr Lys Cys Gln Ala  Ser Thr Pro 
    1745                 1750                 1755             


Ala Arg  Thr Leu Thr Ser Asp  Trp Arg Thr Val Gly  Ser Gln His 
    1760                 1765                 1770             


Gly Val  Thr Val Thr Glu Ser  Asp Ser Tyr Ser Ala  Ser Leu Ser 
    1775                 1780                 1785             


Gln Asp  Thr Asp Lys Gly Arg  Asn Ser Met Val Ser  Thr Glu Ser 
    1790                 1795                 1800             


Ala Ser  Ser Thr Tyr Glu Glu  Leu Ala Arg Ala Tyr  Glu His Ala 
    1805                 1810                 1815             


Lys Leu  Glu Glu Gln Leu Gln  His Ala Lys Phe Glu  Ile Thr Glu 
    1820                 1825                 1830             


Cys Phe  Ile Ser Asp Ser Ser  Ser Asp Gln Met Thr  Thr Gly Thr 
    1835                 1840                 1845             


Asn Glu  Asn Ala Asp Ser Met  Thr Ser Met Ser Thr  Pro Ser Glu 
    1850                 1855                 1860             


Pro Gly  Ile Cys Arg Phe Thr  Ala Ser Pro Pro Lys  Pro Gln Asp 
    1865                 1870                 1875             


Ala Asp  Arg Gly Lys Asn Val  Ala Val Pro Ile Pro  His Arg Ala 
    1880                 1885                 1890             


Asn Lys  Ser Asp Tyr Cys Asn  Leu Pro Leu Tyr Ala  Lys Ser Glu 
    1895                 1900                 1905             


Ala Phe  Phe Arg Lys Ala Asp  Gly Arg Glu Pro Cys  Pro Val Val 
    1910                 1915                 1920             


Pro Pro  Arg Glu Ala Ser Ile  Arg Asn Leu Ala Arg  Thr Tyr His 
    1925                 1930                 1935             


Thr Gln  Ala Arg His Leu Thr  Leu Asp Pro Ala Ser  Lys Ser Leu 
    1940                 1945                 1950             


Gly Leu  Pro His Pro Gly Ala  Pro Ala Ala Ala Ser  Thr Ala Thr 
    1955                 1960                 1965             


Leu Pro  Gln Arg Thr Leu Ala  Met Pro Ala Pro Pro  Ala Gly Thr 
    1970                 1975                 1980             


Ala Pro  Pro Ala Pro Gly Pro  Thr Pro Ala Glu Pro  Pro Thr Ala 
    1985                 1990                 1995             


Pro Ser  Ala Ala Pro Pro Ala  Pro Ser Thr Glu Pro  Pro Arg Ala 
    2000                 2005                 2010             


Gly Gly  Pro His Thr Lys Met  Gly Gly Ser Arg Asp  Ser Leu Leu 
    2015                 2020                 2025             


Glu Met  Ser Thr Ser Gly Val  Gly Arg Ser Gln Lys  Gln Gly Ala 
    2030                 2035                 2040             


Gly Ala  Tyr Ser Lys Ser Tyr  Thr Leu Val 
    2045                 2050             


<210>  938
<211>  648
<212>  DNA
<213>  Homo sapiens

<400>  938
agccgagcgc tgggctgagg agcagagaga gcggggcgcc gagtgcgggc ggctgggagc       60

gcgctgagcg ggggagaggc gctgccgcac ggccggccac aggaccacct ccccggagaa      120

tagggcctct ttatggcatg tggctggtaa ctttcctcct gctcctggac tctttacaca      180

aagcccgccc tgaagatgtt ggcaccagcc tctactttgt aaatgactcc ttgcagcagg      240

tgaccttttc cagctccgtg ggggtggtgg tgccctgccc ggccgcgggc tcccccagcg      300

cggcccttcg atggtacctg gccacagggg acgacatcta cgacgtgccg cacatccggc      360

acgtccacgc caacgggacg ctgcagctct accccttctc cccctccgcc ttcaatagct      420

ttatccacga caatgactac ttctgcaccg cggagaacgc tgccggcaag atccggagcc      480

ccaacatccg cgtcaaagca gttttcaggg aaccctacac cgtccgggtg gaggatcaaa      540

ggtcaatgcg tggcaacgtg gccgtcttca agtgcctcat cccctcttca gtgcaggaat      600

atgttagcgt tgtatcttgg gagaaagaca cagtctccat catcccag                   648


<210>  939
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  939

Met Trp Leu Val Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys Ala 
1               5                   10                  15      


Arg Pro Glu Asp Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser Leu 
            20                  25                  30          


Gln Gln Val Thr Phe Ser Ser Ser Val Gly Val Val Val Pro Cys Pro 
        35                  40                  45              


Ala Ala Gly Ser Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr Gly 
    50                  55                  60                  


Asp Asp Ile Tyr Asp Val Pro His Ile Arg His Val His Ala Asn Gly 
65                  70                  75                  80  


Thr Leu Gln Leu Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe Ile 
                85                  90                  95      


His Asp Asn Asp Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys Ile 
            100                 105                 110         


Arg Ser Pro Asn Ile Arg Val Lys Ala Val Phe Arg Glu Pro Tyr Thr 
        115                 120                 125             


Val Arg Val Glu Asp Gln Arg Ser Met Arg Gly Asn Val Ala Val Phe 
    130                 135                 140                 


Lys Cys Leu Ile Pro Ser Ser Val Gln Glu Tyr Val Ser Val Val Ser 
145                 150                 155                 160 


Trp Glu Lys Asp Thr Val Ser Ile Ile Pro 
                165                 170 


<210>  940
<211>  485
<212>  DNA
<213>  Homo sapiens

<400>  940
actcgccgca gcctgcgcgc cttctccagt ccgcggtgcc atggcccccg cccgtctgtt       60

cgcgctgctg ctgttcttcg taggcggagt cgccgagtcg atccgagaga ctgaggtcat      120

cgacccccag gacctcctag aaggccgata cttctccgga gccctaccag acgatgagga      180

tgtagtgggg cccgggcagg aatctgatga ctttgagctg tctggctctg gagatctgga      240

tgacttggaa gactccatga tcggccctga agttgtccat cccttggtgc ctctagataa      300

ccatatccct gagagggcag ggtctgggag ccaagtcccc accgaaccca agaaactaga      360

ggagaatgag gttatcccca agagaatctc acccgttgaa gagagtgagg atgtgtccaa      420

caaggtgtca atgtccagca ctgtgcaggg cagcaacatc tttgagagaa cggaggtcct      480

ggcag                                                                  485


<210>  941
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  941

Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly 
1               5                   10                  15      


Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu 
            20                  25                  30          


Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val 
        35                  40                  45              


Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly 
    50                  55                  60                  


Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His 
65                  70                  75                  80  


Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly 
                85                  90                  95      


Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile 
            100                 105                 110         


Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys 
        115                 120                 125             


Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr 
    130                 135                 140                 


Glu Val Leu Ala 
145             


<210>  942
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7 promoter

<400>  942
cagagatgca taatacgact cactataggg aga                                    33


