               SEQUENCE LISTING

<110> INOTREM
      DERIVE Marc
      GARAUD Jean-Jacques
      BOUFENZER Amir
      MAILLEFER Marine
      VOISON-CHRISTOPHE Julie
      CARRASCO Kévin

<120> ANTI-TREM-1 ANTIBODIES

<130> IBIO-2027/PCT

<150> EP21305743.3
<151> 2021-06-02

<160> 61

<170> BiSSAP 1.3.6

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VH

<400> 1
Asn Thr Tyr Ile His 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<220> 
<221> SITE
<222> 6
<223> X is N or G

<220> 
<221> SITE
<222> 8
<223> X is N or R

<220> 
<221> SITE
<222> 12
<223> X is A, D, or S

<220> 
<221> SITE
<222> 16
<223> X is Q or K

<400> 2
Arg Ile Asp Pro Ala Xaa Gly Xaa Thr Lys Tyr Xaa Pro Lys Val Xaa 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VH

<220> 
<221> SITE
<222> 2
<223> X is Y or R

<220> 
<221> SITE
<222> 4
<223> X is S or G

<400> 3
His Xaa Gly Xaa Thr Met Asp Tyr 
1               5               

<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<220> 
<221> SITE
<222> 4
<223> X is E or Q

<220> 
<221> SITE
<222> 7
<223> X is D or S

<220> 
<221> SITE
<222> 14
<223> X is M or L

<400> 4
Arg Ala Ser Xaa Ser Val Xaa Asn Tyr Gly Ile Ser Phe Xaa Asn 
1               5                   10                  15  

<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<220> 
<221> SITE
<222> 3
<223> X is S or E

<220> 
<221> SITE
<222> 4
<223> X is N or Y

<220> 
<221> SITE
<222> 5
<223> X is Q or R

<220> 
<221> SITE
<222> 6
<223> X is G, A, or K

<220> 
<221> SITE
<222> 7
<223> X is S or R

<400> 5
Ala Ala Xaa Xaa Xaa Xaa Xaa 
1               5           

<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VL

<220> 
<221> SITE
<222> 4
<223> X is K, R, or S

<220> 
<221> SITE
<222> 5
<223> X is E, H, or N

<220> 
<221> SITE
<222> 6
<223> X is V or F

<220> 
<221> SITE
<222> 8
<223> X is W or Y

<400> 6
Gln Gln Ser Xaa Xaa Xaa Pro Xaa Thr 
1               5                   

<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 7
Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Asp Pro Lys Val Lys 
1               5                   10                  15      
Gly 
    

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VH

<400> 8
His Tyr Gly Gly Thr Met Asp Tyr 
1               5               

<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<400> 9
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Leu Asn 
1               5                   10                  15  

<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<400> 10
Ala Ala Glu Tyr Arg Gly Arg 
1               5           

<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VL

<400> 11
Gln Gln Ser Arg His Val Pro Tyr Thr 
1               5                   

<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 12
Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Ser Pro Lys Val Gln 
1               5                   10                  15      
Gly 
    

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VH

<400> 13
His Arg Gly Gly Thr Met Asp Tyr 
1               5               

<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<400> 14
Arg Ala Ser Gln Ser Val Ser Asn Tyr Gly Ile Ser Phe Leu Asn 
1               5                   10                  15  

<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<400> 15
Ala Ala Ser Tyr Gln Lys Arg 
1               5           

<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VL

<400> 16
Gln Gln Ser Ser Asn Phe Pro Trp Thr 
1               5                   

<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 17
Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Ala Pro Lys Val Lys 
1               5                   10                  15      
Gly 
    

<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VL

<400> 18
Gln Gln Ser Ser Asn Val Pro Tyr Thr 
1               5                   

<210> 19
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 19
Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Ala Pro Lys Val Gln 
1               5                   10                  15      
Gly 
    

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<400> 20
Ala Ala Glu Tyr Gln Gly Arg 
1               5           

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<400> 21
Ala Ala Glu Tyr Arg Ala Arg 
1               5           

<210> 22
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 22
Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Val Gln 
1               5                   10                  15      
Gly 
    

<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VH

<400> 23
His Tyr Gly Ser Thr Met Asp Tyr 
1               5               

<210> 24
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 VL

<400> 24
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  

<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VL

<400> 25
Ala Ala Ser Asn Gln Gly Ser 
1               5           

<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 VL

<400> 26
Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   

<210> 27
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Asp Asn Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Asp Pro Lys Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly His Tyr Gly Gly Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 28
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Gly Asn Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Ser Pro Lys Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Pro Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly His Arg Gly Gly Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 29
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Gly Asn Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Ala Pro Lys Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Asp Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly His Arg Gly Gly Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 30
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Gly Asn Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Ala Pro Lys Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly His Tyr Gly Gly Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 31
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Gly Asn Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Gly Gly Arg Thr Lys Tyr Ala Pro Lys Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly His Arg Gly Gly Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 32
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Val 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly His Tyr Gly Ser Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 33
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 33
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Glu Tyr Arg Gly Arg Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Arg 
                85                  90                  95      
His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210> 34
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 34
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Ser Tyr Gln Lys Arg Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      
Asn Phe Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210> 35
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 35
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Glu Tyr Arg Gly Arg Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      
Asn Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210> 36
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 36
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Glu Tyr Gln Gly Arg Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      
Asn Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 37
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 37
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Glu Tyr Arg Ala Arg Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      
Asn Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210> 38
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 38
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<220> 
<221> SITE
<222> 6
<223> X is N or G

<220> 
<221> SITE
<222> 8
<223> X is N or R

<220> 
<221> SITE
<222> 12
<223> X is A, D, or S

<220> 
<221> SITE
<222> 16
<223> X is Q or K

<400> 39
Arg Ile Asp Pro Ala Xaa Gly Xaa Thr Lys Tyr Xaa Pro Lys Phe Xaa 
1               5                   10                  15      
Gly 
    

<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 VH

<400> 40
Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 41
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> VH

<400> 41
Ala Val Gln Leu Gln Gln Ser Val Ala Ala Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asp Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Thr Gly His Tyr Gly Ser Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 42
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> VL

<400> 42
Glu Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Thr Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  
Pro Met Glu Asp Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 43
<211> 234
<212> PRT
<213> Homo sapiens


<220> 
<223> TREM-1

<400> 43
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         
Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             
Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 
Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 

<210> 44
<211> 150
<212> PRT
<213> Homo sapiens


<220> 
<223> TREM-1

<400> 44
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Arg Cys Ser Thr Leu Ser Phe 
    130                 135                 140                 
Ser Trp Leu Val Asp Ser 
145                 150 

<210> 45
<211> 225
<212> PRT
<213> Homo sapiens


<220> 
<223> TREM-1

<400> 45
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         
Thr Asn Val Thr Asp Ile Ile Arg Tyr Ser Phe Gln Val Pro Gly Pro 
        195                 200                 205             
Leu Val Trp Thr Leu Ser Pro Leu Phe Pro Ser Leu Cys Ala Glu Arg 
    210                 215                 220                 
Met 
225 

<210> 46
<211> 250
<212> PRT
<213> Homo sapiens


<220> 
<223> TREM-1

<400> 46
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         
Thr Asn Val Thr Asp Ile Ile Arg Glu Lys Ser Met Thr Phe Gly Ile 
        195                 200                 205             
Arg Arg Leu Asp Val Glu Ser His Pro Leu Pro Pro Leu His Thr Gly 
    210                 215                 220                 
His Phe Arg Ile Ser Gln Phe Phe Ser Gln Ala Gly Thr Gln Ser Leu 
225                 230                 235                 240 
His Ser Cys Tyr Lys Gly Lys Pro Thr Pro 
                245                 250 

<210> 47
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 47
gaggtgcagc tggtggagtc tggaggcgct ctcgtgaagc ctggcggctc tctcagactc      60

tcttgcgctg cctccggctt caacatcgac aacacctaca tccactgggt gcggcaggct     120

cctggaaagg gactcgagtg gatcggaaga atcgaccctg ctggagggag aaccaagtac     180

gaccccaagg tcaaggggcg gttcaccatc tctgccgaca cctccaagaa caccgcctac     240

ctgcagatga acagcctcaa gaccgaggac accgctgtct actactgcac cgggcactac     300

ggagggacaa tggattactg gggacagggg acactcgtca ccgtctctag c              351


<210> 48
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 48
gaggtgcagc tggtggagtc tggaggcgct ctcgtgaagc ctggcggctc tctcagactc      60

tcttgcgctg cctccggctt caacatcgga aacacctaca tccactgggt gcggcaggct     120

cctggaaagg gactcgagtg gatcggaaga atcgaccctg ctggagggag aaccaagtac     180

tccccaaagg tccaggggcg gttcaccatc tctgccccta cctccaagaa caccgcctac     240

ctgcagatga acagcctcaa gaccgaggac accgctgtct actactgtac cgggcacagg     300

ggagggacaa tggattactg gggacagggg acactcgtca ccgtctctag c              351


<210> 49
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 49
gaggtgcagc tggtggagtc tggaggcgct ctggtgaagc ctggcggctc tctgagactg      60

tcttgcgctg cctccggctt caacatcggc aacacctaca tccactgggt gcggcaggct     120

cctggaaagg gactggagtg ggtgggcaga atcgatcctg ctggcggaag aaccaagtac     180

gccccaaagg tgaagggacg gttcaccatc tctgccgacg actccaagaa caccgcctac     240

ctccagatga actccctcaa gaccgaggac accgctgtgt actactgtac cggacaccgg     300

ggagggacaa tggattactg gggacagggg acactcgtga ccgtgtcttc c              351


<210> 50
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 50
gaggtgcagc tggtggagtc tggaggcgct ctggtgaagc ctggcggctc tctgagactg      60

tcttgcgctg cctccggctt caacatcggc aacacctaca tccactgggt gcggcaggct     120

cctggaaagg gactggagtg gatcggcaga atcgaccctg ctggcggaag aaccaagtac     180

gccccaaagg tgcagggacg gttcaccatc tctgccgaca cctccaagaa caccgcctac     240

ctccagatga actccctcaa gaccgaggac accgccgtgt actactgcac cggacactac     300

ggagggacaa tggattactg gggacagggg acactcgtga ccgtgtcttc c              351


<210> 51
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 51
gaggtgcagc tggtggagtc tggaggcgct ctggtgaagc ctggcggctc tctcagactc      60

tcttgcgctg cctccggctt caacatcgga aacacctaca tccactgggt gcggcaggct     120

cctggaaagg gactcgagtg ggtcggaaga atcgatcctg ctggagggag aaccaagtac     180

gccccaaagg tcaaggggcg gttcaccatc tctgccgacg actccaagaa caccctgtac     240

ctccagatga acagcctcaa gaccgaggac accgctgtct actactgtac cgggcacagg     300

ggagggacaa tggattactg gggacagggg acactcgtca ccgtctctag c              351


<210> 52
<211> 351
<212> DNA
<213> Artificial Sequence


<220> 
<223> VH

<400> 52
gaggtgcagc tggtggagtc tggaggcgct ctggtgaagc ctggcggctc tctgagactg      60

tcttgcgctg cctccggctt caacatcaag aacacctaca tccactgggt gcggcaggct     120

cctggaaagg gactggagtg gatcggccgg atcgaccctg ctaacggcaa caccaagtac     180

gccccaaagg tgcagggacg gttcaccatc tctgccgaca cctccaagaa caccgcctac     240

ctccagatga actccctcaa gaccgaggac accgccgtgt actactgcac cggacactac     300

ggatccacca tggactactg gggacagggg acactcgtga ccgtgtcttc c              351


<210> 53
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 53
gagatcgtcc tgacccagtc tcctgccacc ctgtctctct ctcccggcga aagagccacc      60

ctctcttgca gagcctccga gtccgtggac aactacggca tctccttcct caactggtac     120

caacagaagc ctggacaggc ccctaggctc ctcatctacg ctgctgagta caggggaagg     180

ggaatccccg ctaggttctc tgggagtggg tctgggaccg acttcaccct caccatctcc     240

tccctcgagc ccgaggactt cgctgtgtac tactgccagc agtcccggca cgtgccttac     300

accttcgggc aggggaccaa ggtggagatc aag                                  333


<210> 54
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 54
gagatcgtcc tgacccagtc tcctgccacc ctgtctctgt ctcccggcga gagagccacc      60

ctgtcttgca gagcctccca gtccgtgtcc aactacggca tctccttcct gaactggtac     120

caacagaagc ctggccaggc ccctagactc ctcatctacg ccgcctctta ccagaagcgg     180

ggcatccccg ccagattctc tggatctgga tctggaaccg acttcaccct caccatctcc     240

tccctcgagc ccgaggactt cgcagtgtac tactgccagc agtcctccaa cttcccctgg     300

accttcggac aggggaccaa ggtggagatc aag                                  333


<210> 55
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 55
gagatcgtcc tgacccagtc tcctgccacc ctgtctctgt ctcccggcga gagagccacc      60

ctgtcttgca gagcctccca gtccgtgtcc aactacggca tctccttcct gaactggtac     120

caacagaagc ctggccaggc ccctagactc ctcatctacg ccgccgagta cagaggcaga     180

ggcatccccg ccagattctc tggatctgga tctggaaccg acttcaccct caccatctcc     240

tccctcgagc ccgaggactt cgcagtgtac tactgccagc agtcctccaa cgtgccctac     300

accttcggcc aggggaccaa ggtggagatc aag                                  333


<210> 56
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 56
gagatcgtcc tgacccagtc tcctgccacc ctgtctctgt ctcccggcga gagagccacc      60

ctgtcttgca gagcctccca gtccgtgtcc aactacggca tctccttcct gaactggtac     120

caacagaagc ctggccaggc ccctagactg ctcatctacg ccgccgagta ccagggcaga     180

ggcatccctg ccagattctc tggatctgga tctggaaccg acttcaccct caccatctcc     240

tccctcgagc ccgaggactt cgcagtgtac tactgccagc agtcctccaa cgtgccctac     300

accttcggcc aggggaccaa gctcgagatc aag                                  333


<210> 57
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 57
gagatcgtcc tgacccagtc tcctgccacc ctgtctctct ctcccggcga aagagccacc      60

ctctcttgca gagcctccca gtccgtgtcc aactacggaa tctccttcct caactggtac     120

caacagaagc ctggacaggc ccctaggctc ctcatctacg cagctgagta cagggctagg     180

ggaatccccg ctaggttctc tggatctggg agtgggaccg acttcaccct caccatctcc     240

tccctggagc ccgaggactt cgctgtgtac tactgccagc agtcctccaa cgtgccttac     300

accttcgggc aggggaccaa ggtggagatc aag                                  333


<210> 58
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> VL

<400> 58
gagatcgtcc tgacccagtc tcctgccacc ctgtctctgt ctcccggcga gagagccacc      60

ctgtcttgca gagcctccga gtccgtggac aactacggca tctccttcat gaactggttc     120

caacagaagc ctggccaggc ccctagactg ctcatctacg ccgcctctaa ccagggctct     180

ggcatccccg ccagattctc tggatctgga tctggaaccg acttcaccct caccatctcc     240

tccctcgagc ccgaggactt cgcagtgtac ttctgccagc agtccaagga ggtcccttgg     300

acctttgggc aggggaccaa ggtggagatc aag                                  333


<210> 59
<211> 585
<212> PRT
<213> Homo sapiens


<220> 
<223> HSA

<400> 59
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      
Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          
Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              
Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  
Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  
Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      
Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         
Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             
Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 
Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 
Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     
Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         
Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             
Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 
Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 
Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     
Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         
Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             
Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 
Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 
Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     
Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         
Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             
Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 
Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 
Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     
Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         
Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             
Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 
Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 
Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     
Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         
Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             
Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 
Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 
Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     
Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 

<210> 60
<211> 585
<212> PRT
<213> Homo sapiens


<220> 
<223> HSA

<400> 60
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      
Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          
Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              
Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  
Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  
Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      
Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         
Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             
Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 
Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 
Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     
Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         
Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             
Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 
Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 
Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     
Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         
Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             
Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 
Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 
Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     
Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         
Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             
Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 
Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 
Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     
Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         
Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             
Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 
Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 
Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     
Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         
Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             
Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 
Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 
Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     
Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 

<210> 61
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> LR12

<400> 61
Leu Gln Glu Glu Asp Ala Gly Glu Tyr Gly Cys Met 
1               5                   10          

