                         SEQUENCE LISTING

<110>  Eberhart Karls Universitt Tbingen
 
<120>  Antisense Oligonucleotides (ASO) for Efficient and Precise RNA 
       Editing with Endogenous Adenosine Deaminase Acting on RNA (ADAR)

<130>  PWO00361UNI

<150>  EP21177135.7
<151>  2021-06-01

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.1

<400>  1
mumumgucau ggaugaccuu ggccaggggu gccaagcagu ugguggugca ggaggcauum       60

gmcmu                                                                   65


<210>  2
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V116.16

<400>  2
mumumgucau ggaugaccuu ggccaggggu gccaagcagu ugguggugca ggaggcauum       60

gmcmu                                                                   65


<210>  3
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.17

<400>  3
mumumgucau ggaugaccuu ggccaggggu gccaagcagu ugguggugca ggaggcauum       60

gmcmu                                                                   65


<210>  4
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.18

<400>  4
mumumgucau ggaugaccuu ggccaggggu gccaagcagu ugguggugca ggaggcauum       60

gmcmu                                                                   65


<210>  5
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.19

<400>  5
mumumgucau ggaugaccuu ggccaggggu gccaagcagu ugguggugca ggaggcauum       60

gmcmu                                                                   65


<210>  6
<211>  53
<212>  DNA
<213>  artificial sequence

<220>
<223>  V118.3

<400>  6
mumgmgauga ccuuggccag gggugccaag caguuggugg ugcaggamgm gmc              53


<210>  7
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V119.1

<400>  7
mumcmcuucc acgauaccaa aguugucaug gaugaccuug gccaggggug ccaagcagum       60

umgmg                                                                   65


<210>  8
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V119.4

<400>  8
mumcmcuucc acgauaccaa aguugucaug gaugaccuug gccaggggug ccaagcagum       60

umgmg                                                                   65


<210>  9
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  9
mcmamaaguu gucauggaug accuuggcca ggggugccaa gcagumumgm g                51


<210>  10
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  V121.1

<400>  10
mumumgucau ggaugaccuu ggccaggggu gccaagcagu mumgmg                      46


<210>  11
<211>  41
<212>  DNA
<213>  artificial sequence

<220>
<223>  V122.1

<400>  11
mamumggaug accuuggcca ggggugccaa gcagumumgm g                           41


<210>  12
<211>  135
<212>  DNA
<213>  artificial sequence

<220>
<223>  V25.1, comparison

<400>  12
mgmgmugmum cgagaagagg agaamcaamu amugmcmuaa amugmumugm umumcmumcg       60

mumcmumcmc mumcgamcam cmcuugucau ggaugaccuu ggccamggmg mgmumgccam      120

amgmcmagmu mugmg                                                       135


<210>  13
<211>  87
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.7

<400>  13
mcmamamamg mumumgmumc mamumgmgma mumgmamcmc mumumgmgmc mcmamgmgmg       60

mgmumgccam amgmcmamgm umumgmg                                           87


<210>  14
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.13

<400>  14
mcmamaaguu gucauggaug accuuggcca ggggugccaa gcagumumgm g                51


<210>  15
<211>  62
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.15

<400>  15
mcamaamgum ugmucmaumg gmaumgamcc muumggmccm aggggugcca agcagumumg       60

mg                                                                      62


<210>  16
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.15

<400>  16
mcaamagumu gumcaumgga mugamccumu ggmccagggg ugccaagcag umumgmg          57


<210>  17
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.16

<400>  17
dcaadagudt gudcaudgga dtgadccudt ggdccagggg ugccaagcag umumgmg          57


<210>  18
<211>  53
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.17

<400>  18
mcmamaaguu gucauggaug accuuggcca ggggugdcdc aagcagumum gmg              53


<210>  19
<211>  68
<212>  DNA
<213>  artifi1ial0seq
enc0

(<220>
<223g  V120.18

<400>  19
mcmamaagmu mugmumcamu ggamugamcm cmumuggmcm caggggmugd cdcaagmcag       60

mumumgmg                                                                68


<210>  20
<211>  47
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.19

<400>  20
caaaguuguc auggaugacc uuggccaggg gugdcdcaag caguugg                     47


<210>  21
<211>  53
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.20

<400>  21
mcmamaaguu gucauggaug accuuggcca ggggugdcdc aagcagumum gmg              53


<210>  22
<211>  87
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.27

<400>  22
mumumgmumc amuggamuga mcmcmumugg mcmcaggggm ugdcdcaagm cagmumuggm       60

uggmugmcag gaggmcamum umgmcmu                                           87


<210>  23
<211>  67
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.28

<400>  23
mumumgucau ggaugaccuu ggccaggggu gdcdcaagca guugguggug caggaggcau       60

umgmcmu                                                                 67


<210>  24
<211>  67
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.29

<400>  24
mumumgucau ggaugaccuu ggccaggggu gdcdcaagca guugguggug caggaggcau       60

umgmcmu                                                                 67


<210>  25
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  25
mamamcuuca gacacagaaa ucaacucagu cuugauacau ccagumumcm c                51


<210>  26
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.19

<400>  26
mcmamgacac agaaaucaac ucagucuuga uacauccagu uccuuuaggg ccaucaagum       60

umcmc                                                                   65


<210>  27
<211>  68
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.28

<400>  27
mcmamgacac agaaaucaac ucagucuuga udadcdaucc aguuccuuua gggccaucaa       60

gumumcmc                                                                68


<210>  28
<211>  132
<212>  DNA
<213>  artificial sequence

<220>
<223>  V25.1, comparison

<400>  28
mgmgmugmum cgagaagagg agaamcaamu amugmcmuaa amugmumugm umumcmumcg       60

mumcmumcmc mumcgacacc cagacacaga aaucaacuca gumctmumgm amuacamumc      120

mcmagmumuc mc                                                          132


<210>  29
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  29
mumcmggcca gacuuccuuu guuuaagcuu ucguguccaa ccuucmamgm g                51


<210>  30
<211>  53
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.21

<400>  30
mumcmggcca gacuuccuuu guuuaagcuu ucgugudcdc aaccuucmam gmg              53


<210>  31
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.22

<400>  31
mcmumuucgu guccaaccuu caggcaaggu ggggucauca uacaumamgm g                51


<210>  32
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.1 9 exon

<400>  32
mgmgmacggu cccggccugc gacacuucgg cccagagcug cuccucaucc agcagcgccm       60

amgmc                                                                   65


<210>  33
<211>  68
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.20 exon

<400>  33
mgmgmacggu cccggccugc gacacuucgg cdcdcdagag cugcuccuca uccagcagcg       60

ccmamgmc                                                                68


<210>  34
<211>  83
<212>  DNA
<213>  artificial sequence

<220>
<223>  V 117.21 exon

<400>  34
mgmgmacggm ucmccggmcc mugcgamcac muumcggcdc dcdagagmcu gmcumccmuc       60

amucmcagca gmcgcmcmam gmc                                               83


<210>  35
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.19 intron

<400>  35
mgmgmacggu cccggccugc gacacuucgg cccagagcug cuccucaucu gcggggcggm       60

gmgmg                                                                   65


<210>  36
<211>  66
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.28 intron

<400>  36
mgmgmacggu cccggccgcg acacuucggc dcdcagagcu gcuccucauc ugcggggcgg       60

mgmgmg                                                                  66


<210>  37
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  37
mgmumccagg acggucccgg ccugcgacac uucggcccag agcugmcmum c                51


<210>  38
<211>  53
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.1 7

<400>  38
mgmumccagg acggucccgg ccugcgacac uucggcdcdc agagcugmcm umc              53


<210>  39
<211>  100
<212>  DNA
<213>  artificial sequence

<220>
<223>  ADAR 6 5- 30 comparison

<400>  39
mcmumgmumc mcmamamcma mcmamgmcmc mcmcmamgmc mcmumumumg mamgmamcmc       60

mumcmumgmu dcdcdamgma mgmumumgmu mumcmumcmc                            100


<210>  40
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  40
mgmumccaac acagccccag ccuuugagac cucugcccag aguugmumum c                51


<210>  41
<211>  53
<212>  DNA
<213>  artificial sequence

<220>
<223>  V121.21

<400>  41
mgmumccaac acagccccag ccuuugagac cucugcdcdc agaguugmum umc              53


<210>  42
<211>  63
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.23

<400>  42
mgmumcmcaa camcagcmcc mcagcmcumu ugagamccmu cmugcdcdca gagmuugmum       60

umc                                                                     63


<210>  43
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117-19

<400>  43
mgmgmuacuc ucauaugucu uugacugauc cacaaucuuc uggaacaugg uccuuuucum       60

umgma                                                                   65


<210>  44
<211>  68
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.20

<400>  44
mgmgmuacuc ucauaugucu uugacugauc cdadcdaauc uucuggaaca ugguccuuuu       60

cumumgma                                                                68


<210>  45
<211>  85
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.21

<400>  45
mgmgmuacmu cmucamuaug mucmuumuga cmugaumccd adcdaamucm uumcuggaam       60

cauggmucmc umuumucmum umgma                                             85


<210>  46
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  46
mumcmcuggg uacucucaua ugucuuugac ugauccacaa ucuucmumgm g                51


<210>  47
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.3

<400>  47
mumcmcuggg uacucucaua ugucuuugac ugauccdadc daaucuucmu mgmg             54


<210>  48
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.19

<400>  48
mumumcacuc ucauaugucu uagacugauc cacgaucuuu uggaacaucg uccucuucum       60

umgma                                                                   65


<210>  49
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  49
mumcmcuguu cacucucaua ugucuuagac ugauccacga ucuuumumgm g                51


<210>  50
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.17

<400>  50
mumcmcuguu cacucucaua ugucuuagac ugauccdadc dgaucuuumu mgmg             54


<210>  51
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.19

<400>  51
mcmamuggcc ccagcagcuu cagucccuuu cucgucgaug gucagcacag ccuuaugcam       60

cmgmg                                                                   65


<210>  52
<211>  67
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.24

<400>  52
mgmamugguc agcacagccu uaugcacggc mcmucggaga gcuucagggg ugccuccucu       60

gmumgma                                                                 67


<210>  53
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  V117.25

<400>  53
mcmamuggcc ccagcagcuu cagucccuuc dtdcducgau ggucagcaca gccuuaugca       60

mcmgmg                                                                  66


<210>  54
<211>  81
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.26

<400>  54
mcmamuggcm ccmcagcagm cumucagmuc mccmuumucd tdcdmucgam uggumcagca       60

mcagcmcumu augcamcmgm g                                                 81


<210>  55
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  55
mamamaaaca uggccccagc agcuucaguc ccuuucucgu cgaugmgmum c                51


<210>  56
<211>  52
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.10

<400>  56
mamamaaaca uggccccagc agcuucaguc ccugucmucg ucgaugmgmu mc               52


<210>  57
<211>  62
<212>  DNA
<213>  artificial sequence

<220>
<223>  ADAR60-6 comparison

<400>  57
mumcmamgmu mcmcmcmumu mumcdtdcdg mumcmgmamu mgmgmumcma mgmcmamcma       60

mg                                                                 (    62


<210>  58
<211>  58
<212>  DNA
<213>  artificial sequence

<220>
<223>  ADAR60-10 comparison

<400>  58
mumcmamgmu mcmcmcmumu mumcucmumc mgmamumgmg mumcmamgmc mamcmamg         58


<210>  59
<211>  65
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.19

<400>  59
mcmcmccauu cuacagcagu acugagcaau gccduaguca gcaaucuuug caaugauggm       60

cmamg                                                                   65


<210>  60
<211>  79
<212>  DNA
<213>  artificial sequence

<220>
<223>  V117.20

<400>  60
mcmcmccamu umcuamcagc agmuacmuga gcaamugdcd cduagmucag mcaaumcumu       60

ugmcaaugam uggmcmamg                                                    79


<210>  61
<211>  51
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.2

<400>  61
mumumuaucc ccauucuaca gcaguacuga gcaaugccdu agucamgmcm a                51


<210>  62
<211>  62
<212>  DNA
<213>  artificial sequence

<220>
<223>  V120.3

<400>  62
mumumuaumc cmccamuumc uamcagcagm uacmugagca amugdcdcdu agmucamgmc       60

ma                                                                      62


