                         SEQUENCE LISTING

<110>  Nanjing Legend Biotech Co., Ltd.
 
<120>  ANTIBODIES TARGETING AFP PEPTIDE/MHC COMPLEXES AND USES THEREOF

<130>  P11161-PCT

<150>  PCT/CN2021/097081
<151>  2021-05-31

<160>  435   

<170>  PatentIn version 3.5

<210>  1
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala 
1               5                   10                  15      


Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His 
            20                  25                  30          


Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu 
        35                  40                  45              


Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr 
    50                  55                  60                  


Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala 
65                  70                  75                  80  


Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp 
                85                  90                  95      


Asp Arg Asp Met 
            100 


<210>  2
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02:01 ECD-BSP

<400>  2

Met Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro 
1               5                   10                  15      


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
            20                  25                  30          


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
        35                  40                  45              


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu 
    50                  55                  60                  


Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly 
65                  70                  75                  80  


Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val 
                85                  90                  95      


Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg 
            100                 105                 110         


Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
        115                 120                 125             


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr 
    130                 135                 140                 


Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr 
145                 150                 155                 160 


Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly 
                165                 170                 175     


Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His 
            180                 185                 190         


His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser 
        195                 200                 205             


Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp 
    210                 215                 220                 


Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
225                 230                 235                 240 


Thr Phe Gln Lys Trp Val Ala Val Val Val Pro Ser Gly Gln Glu Gln 
                245                 250                 255     


Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr 
            260                 265                 270         


Leu Arg Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Leu His His 
        275                 280                 285             


Ile Leu Asp Ala Gln Lys Met Val Trp Asn His Arg 
    290                 295                 300 


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AFP158

<400>  3

Phe Met Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARNTL

<400>  4

Lys Met Asn Ser Phe Ile Asp Glu Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ATG9A

<400>  5

Arg Leu Ile Lys Phe Ile Tyr Asn Ile 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BRCA2

<400>  6

Lys Thr Asn Lys Phe Ile Tyr Ala Ile 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC14A

<400>  7

Arg Leu Asn Lys Lys Ile Tyr Glu Ala 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NR2E1

<400>  8

Lys Leu Asn Lys Ile Ile Ser Glu Ile 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OR1I1

<400>  9

Met Leu Asn Pro Phe Ile Tyr Ser Ile 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OR51B6

<400>  10

Phe Met Asn Pro Phe Ile Tyr Ser Ile 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OR6C1

<400>  11

Met Met Asn Pro Phe Ile Tyr Ser Leu 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTP4A1

<400>  12

Thr Leu Asn Lys Phe Ile Glu Glu Leu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RCL1

<400>  13

Ile Leu Asn Lys Phe Ile Pro Asp Ile 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RP1

<400>  14

Arg Met Asn Gly Ile Ile Tyr Glu Ile 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZNF566

<400>  15

Phe Leu Lys Lys Glu Ile Tyr Glu Ile 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA01

<400>  16

Phe Leu Asp Glu Phe Met Glu Ala Val 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA02

<400>  17

Met Leu Gly Glu Arg Leu Phe Pro Leu 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA03

<400>  18

Leu Leu Ala Ile Leu Pro Tyr Tyr Val 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA04

<400>  19

Tyr Leu Leu Pro Ala Ile Val His Ile 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA05

<400>  20

Gly Leu Met Ala Ile Ala Trp Phe Ile 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA06

<400>  21

Ile Met Leu Glu Ala Leu Glu Arg Val 
1               5                   


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA07

<400>  22

Phe Leu Gly Ile Tyr Thr Val Thr Val Val 
1               5                   10  


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA08

<400>  23

Tyr Met Val Leu Ala Ser Pro Ser Val 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA09

<400>  24

Ile Leu Ala Lys Phe Leu His Trp Leu 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA10

<400>  25

Lys Leu Ser Arg Glu Ile Met Pro Val 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA11

<400>  26

Ser Ile Ile Gly Arg Leu Leu Glu Val 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA12

<400>  27

Ala Leu Val Gly Ala Ile Pro Ser Ile 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA13

<400>  28

Phe Leu Thr Val Phe Ser Pro Phe Met 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA14

<400>  29

Leu Leu Leu Val Ser Leu Trp Gly Leu 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA15

<400>  30

Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA16

<400>  31

Ala Leu Ser Pro Val Ile Pro Leu Ile 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA17

<400>  32

Ile Leu Ile Val Met Val Pro Phe Leu 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA18

<400>  33

Arg Leu Leu Pro Leu Leu Ala Leu Leu 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA19

<400>  34

Arg Leu His Asp Leu Val Leu Pro Leu 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA20

<400>  35

Val Leu Phe Gly Leu Gly Phe Ala Ile 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA21

<400>  36

Leu Leu Phe Gly Met Thr Pro Cys Leu 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA22

<400>  37

Ile Leu Asn Val Asp Val Phe Thr Leu 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA23

<400>  38

Leu Leu Gly Ala Thr Cys Met Phe Val 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA24

<400>  39

Gly Met Gly Pro Leu Leu Ala Thr Val 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA25

<400>  40

Phe Val Gly Glu Phe Phe Thr Asp Val 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA26

<400>  41

Lys Leu Pro Leu Asp Ile Asn Pro Val 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA27

<400>  42

Phe Leu Met Ala Ser Ile Ser Ser Ser 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA28

<400>  43

Ser Leu Asp Pro Thr Thr Ser Pro Val 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA29

<400>  44

Leu Leu Phe Ala Leu Tyr Phe Ser Ala 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA30

<400>  45

Arg Leu Trp Glu Pro Leu Arg Val Val 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA31

<400>  46

Phe Ile Thr Gly Ile Ser Ile Leu Leu 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA32

<400>  47

Val Gln Tyr Leu Gly Met Leu Pro Val 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA33

<400>  48

Tyr Val Thr Ala Met Asp Leu Phe Val 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA34

<400>  49

Ala Leu Thr Pro Val Val Val Thr Leu 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA35

<400>  50

Phe Met Leu Leu Thr Gln Ala Arg Leu 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA36

<400>  51

Phe Met Ser Ala Tyr Ser Gly Val Leu 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA37

<400>  52

Ala Val Gly Ser His Val Tyr Ser Val 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA38

<400>  53

Met Ile Ile Ser His Leu Ser Leu Ile 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA39

<400>  54

Ser Ile Leu Asp Ala Val Gln Arg Val 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA40

<400>  55

Tyr Val Val Thr Trp Ile Val Gly Ala 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA41

<400>  56

Asn Leu Phe Asn Arg Tyr Pro Ala Leu 
1               5                   


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA42

<400>  57

Phe Ile Asp Gln Tyr Tyr Ser Ser Ile 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA43

<400>  58

Val Leu Ala Ser Pro Ser Val Pro Leu 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA44

<400>  59

Ile Leu Thr Gly Leu Asn Tyr Glu Ala 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA45

<400>  60

Ala Leu Ile His His Asn Thr His Leu 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA46

<400>  61

Lys Leu Gly Ala Ser Pro Leu His Val 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA47

<400>  62

Leu Leu Ser Leu Phe Ser Leu Trp Leu 
1               5                   


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA48

<400>  63

Ala Leu Trp Gly Pro Asp Pro Ala Ala Ala 
1               5                   10  


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA49

<400>  64

His Ile Ala Lys Ser Pro Phe Glu Val 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA50

<400>  65

Tyr Leu Asp Glu Leu Ile Lys Asn Thr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A1

<400>  66

Ala Met Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A2

<400>  67

Phe Ala Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A3

<400>  68

Phe Met Ala Lys Phe Ile Tyr Glu Ile 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A4

<400>  69

Phe Met Asn Ala Phe Ile Tyr Glu Ile 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A5

<400>  70

Phe Met Asn Lys Ala Ile Tyr Glu Ile 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A6

<400>  71

Phe Met Asn Lys Phe Ala Tyr Glu Ile 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A7

<400>  72

Phe Met Asn Lys Phe Ile Ala Glu Ile 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A8

<400>  73

Phe Met Asn Lys Phe Ile Tyr Ala Ile 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hAFP158 A9

<400>  74

Phe Met Asn Lys Phe Ile Tyr Glu Ala 
1               5                   


<210>  75
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036

<400>  75

Gln Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Lys Gly Thr Leu Val Thr Ile Ser Ser 
                245                 250     


<210>  76
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VH

<400>  76

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120                 125 


<210>  77
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 VH nucleotide sequence

<400>  77
gcggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgcacag cctctggatt caccttcagt agctatgcca tgagttgggt ccgccaggct      120

ccagggaagg gactcgagtg ggtctcaact attaatagtg gtactggtag cccatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctctat      240

ctgcaattga acagcctgaa aactgaggac acggccatgt attactgtgc aaaaaatttc      300

ttcgacggta gttggtttct tggccctccc gccatggact actggggcaa aggaaccctg      360

gtcaccatct cctca                                                       375


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 HCDR1

<400>  78

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 HCDR1 nucleotide sequence

<400>  79
ggattcacct tcagtagcta tgccatgagt                                        30


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 HCDR2

<400>  80

Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 HCDR2 nucleotide sequence

<400>  81
actattaata gtggtactgg tagcccatac tatgcagact ccgtgaaggg c                51


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 HCDR3

<400>  82

Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  83
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 HCDR3 nucleotide sequence

<400>  83
aatttcttcg acggtagttg gtttcttggc cctcccgcca tggactac                    48


<210>  84
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL

<400>  84

Gln Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110     


<210>  85
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 VL nucleotide sequence

<400>  85
cagcttgtgc tgactcagcc ttcctcggtg tccgggactc caggacagac ggtcaccatc       60

tcctgtgctg gaaccagcag tgatgttggg tctgaaaact atgtctcctg gtaccgacag      120

ctcccaggaa cggcccccaa actcctgatt tatcaggtca ataaacgagc ctcggggatt      180

gctgatcgct tctctggctc caagtcaggt aacacggcct ccatgaccat ctctgggctc      240

caatctgcgg acgaggctga ctattactgt gcctcatata gaagtagcga ccataatatt      300

gtgttcggcg gagggaccca tctgaccgtc ctg                                   333


<210>  86
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 LCDR1

<400>  86

Ala Gly Thr Ser Ser Asp Val Gly Ser Glu Asn Tyr Val Ser 
1               5                   10                  


<210>  87
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 LCDR1 nucleotide sequence

<400>  87
gctggaacca gcagtgatgt tgggtctgaa aactatgtct cc                          42


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 LCDR2

<400>  88

Gln Val Asn Lys Arg Ala Ser 
1               5           


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 LCDR2 nucleotide sequence

<400>  89
caggtcaata aacgagcctc g                                                 21


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 LCDR3

<400>  90

Ala Ser Tyr Arg Ser Ser Asp His Asn Ile Val 
1               5                   10      


<210>  91
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 LCDR3 nucleotide sequence

<400>  91
gcctcatata gaagtagcga ccataatatt gtg                                    33


<210>  92
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723

<400>  92

Gln Ala Gly Leu Thr Gln Pro Pro Ser Met Ser Gly Ser Pro Arg Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Asn Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Lys Asn Arg Pro Ser Gly Val Pro Glu Gln Ile Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ala Lys Asn Val Val Tyr Leu Gln Leu Asn 
        195                 200                 205             


Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Gln 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  93
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 VH

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Asn Val Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  94
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 VH nucleotide sequence

<400>  94
gaggtacagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcctt aattatgcca tgagctgggt ccgccaggct      120

ccaggaaagg gactcgagtg ggtctcatct aatagtggtg ctggtagcac atactattca      180

gactccgtga agggccgatt caccatctcc agagactacg ccaagaacgt tgtgtatctg      240

caattgaaca gcctgaaaac tgaggacacg ggcatgtatt actgtgcaaa agggacgaac      300

gttggtagct ggtcttcctt acattactgg ggccagggga cccaggtcac cgtctcctca      360


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 HCDR1

<400>  95

Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
1               5                   10  


<210>  96
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 HCDR1 nucleotide sequence

<400>  96
ggattcacct tccttaatta tgccatgagc                                        30


<210>  97
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 HCDR2

<400>  97

Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  98
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 HCDR2 nucleotide sequence

<400>  98
tctaatagtg gtgctggtag cacatactat tcagactccg tgaagggc                    48


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 HCDR3

<400>  99

Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr 
1               5                   10          


<210>  100
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 HCDR3 nucleotide sequence

<400>  100
gggacgaacg ttggtagctg gtcttcctta cattac                                 36


<210>  101
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 VL

<400>  101

Gln Ala Gly Leu Thr Gln Pro Pro Ser Met Ser Gly Ser Pro Arg Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Asn Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Lys Asn Arg Pro Ser Gly Val Pro Glu Gln Ile Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110 


<210>  102
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 VL nucleotide sequence

<400>  102
caggcagggc tgactcagcc gccctccatg tctggatccc cgaggcagag tgtcaccatc       60

tcctgcactg gaagcagcaa caacatcggg ggtaattatg taaactggta ccaacatctc      120

ccaggaacgg cccccaaact tctgatctat gataacaaga acaggccctc gggggtcccc      180

gagcagatct ctggctccaa gtctggcagc tctgcctccc tgaccatcac tgggctccag      240

gctgaggacg agggtgacta ttactgcgca tcctgggatg acagcctcag tgctgttgtg      300

ttcggcggag ggacccatct gaccgtcctg                                       330


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 LCDR1

<400>  103

Thr Gly Ser Ser Asn Asn Ile Gly Gly Asn Tyr Val Asn 
1               5                   10              


<210>  104
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 LCDR1 nucleotide sequence

<400>  104
actggaagca gcaacaacat cgggggtaat tatgtaaac                              39


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 LCDR2

<400>  105

Asp Asn Lys Asn Arg Pro Ser 
1               5           


<210>  106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 LCDR2 nucleotide sequence

<400>  106
gataacaaga acaggccctc g                                                 21


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 LCDR3

<400>  107

Ala Ser Trp Asp Asp Ser Leu Ser Ala Val Val 
1               5                   10      


<210>  108
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 LCDR3 nucleotide sequence

<400>  108
gcatcctggg atgacagcct cagtgctgtt gtg                                    33


<210>  109
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732

<400>  109

Asn Phe Met Leu Thr Gln Pro Pro Ser Met Ser Gly Ser Pro Arg Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Asn Arg Ala Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ala Lys Asn Val Val Tyr Leu Gln Leu Asn 
        195                 200                 205             


Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Gln 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  110
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 VL

<400>  110

Asn Phe Met Leu Thr Gln Pro Pro Ser Met Ser Gly Ser Pro Arg Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Asn Arg Ala Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110 


<210>  111
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179732 VL nucleotide sequence

<400>  111
aattttatgc tgactcagcc gccctccatg tctggatccc cgaggcagag tgtcaccatc       60

tcctgcactg gaagcagcag caacatcggg ggtaattatg taaactggta ccaacatctc      120

ccaggaacgg cccccaaact cctgatctat gataacagca acagggcctc gggggtcccc      180

gagcgcttct ctggctccaa gtctggcagc tctgcctccc tgaccatcac tgggctccag      240

gctgaggacg agggtgacta ttactgcgca tcctgggatg acagcctcag tggtgctgtg      300

ttcggcggag ggacccatct gaccgtcctg                                       330


<210>  112
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 LCDR1

<400>  112

Thr Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val Asn 
1               5                   10              


<210>  113
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179732 LCDR1 nucleotide sequence

<400>  113
actggaagca gcagcaacat cgggggtaat tatgtaaac                              39


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 LCDR2

<400>  114

Asp Asn Ser Asn Arg Ala Ser 
1               5           


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179732 LCDR2 nucleotide sequence

<400>  115
gataacagca acagggcctc g                                                 21


<210>  116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 LCDR3

<400>  116

Ala Ser Trp Asp Asp Ser Leu Ser Gly Ala Val 
1               5                   10      


<210>  117
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179732 LCDR3 nucleotide sequence

<400>  117
gcatcctggg atgacagcct cagtggtgct gtg                                    33


<210>  118
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259

<400>  118

Gln Ser Val Val Thr Gln Pro Ser Ala Val Ser Val Ser Leu Glu Glu 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gln Gly Gly Gly Tyr Tyr Val Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Leu Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Ser Lys Ser Gly 
    50                  55                  60                  


Gly Thr Ala Thr Leu Thr Ile Asn Gly Ala Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Ala Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Asn Ser Ala Val Phe 
                85                  90                  95      


Gly Gly Gly Thr His Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Asn Ser Gly Gly Gly 
                165                 170                 175     


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Lys Thr 
        195                 200                 205             


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Lys Ala Ala Ser Gly Tyr Gly 
    210                 215                 220                 


Gly Ser Trp Trp Gly Asp Ala Thr Leu Asp Ala Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  119
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VH

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ala Ser Gly Tyr Gly Gly Ser Trp Trp Gly Asp Ala Thr 
            100                 105                 110         


Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  120
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 VH nucleotide sequence

<400>  120
caggtgcagc tggtgcagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg gactcgagtg ggtctcagct attaatagtg gtggtggtag cacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaattga acagcctgaa aactgaggac acggccatgt attactgtgc aaaagcggcg      300

agcgggtacg gtggtagctg gtggggggac gcgactttgg acgcatgggg ccaggggaca      360

ctggtcactg tctcctca                                                    378


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 HCDR1

<400>  121

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  122
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 HCDR1 nucleotide sequence

<400>  122
ggattcacct tcagtagcta tgccatgagc                                        30


<210>  123
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 HCDR2

<400>  123

Ala Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  124
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 HCDR2 nucleotide sequence

<400>  124
gctattaata gtggtggtgg tagcacatac tatgcagact ccgtgaaggg c                51


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 HCDR3

<400>  125

Ala Ala Ser Gly Tyr Gly Gly Ser Trp Trp Gly Asp Ala Thr Leu Asp 
1               5                   10                  15      


Ala 
    


<210>  126
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 HCDR3 nucleotide sequence

<400>  126
gcggcgagcg ggtacggtgg tagctggtgg ggggacgcga ctttggacgc a                51


<210>  127
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VL

<400>  127

Gln Ser Val Val Thr Gln Pro Ser Ala Val Ser Val Ser Leu Glu Glu 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Gln Gly Gly Gly Tyr Tyr Val Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Leu Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Ala Ser Lys Ser Gly 
    50                  55                  60                  


Gly Thr Ala Thr Leu Thr Ile Asn Gly Ala Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Ala Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Asn Ser Ala Val Phe 
                85                  90                  95      


Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105 


<210>  128
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 VL nucleotide sequence

<400>  128
cagtctgtcg tgacgcagcc ctccgcagtg tccgtgtcct tggaagagac ggccacgatc       60

acctgccaag gaggcggtta ttatgttaat tggtaccagc agaagccagg gcaggcccct      120

gtgttggtca tttatctaaa tactaatagg ccctcgggga tccctgagcg attctctgct      180

tccaagtcgg ggggcacagc caccctgacc atcaacgggg cccaggccga ggatgaggcc      240

gcctattact gtcagtcagc agacagcagt ggtaacagtg ctgtgtttgg cggagggacc      300

catctgaccg tcctg                                                       315


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 LCDR1

<400>  129

Gln Gly Gly Gly Tyr Tyr Val Asn 
1               5               


<210>  130
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 LCDR1 nucleotide sequence

<400>  130
caaggaggcg gttattatgt taat                                              24


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 LCDR2

<400>  131

Leu Asn Thr Asn Arg Pro Ser 
1               5           


<210>  132
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 LCDR2 nucleotide sequence

<400>  132
ctaaatacta ataggccctc g                                                 21


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 LCDR3

<400>  133

Gln Ser Ala Asp Ser Ser Gly Asn Ser Ala Val 
1               5                   10      


<210>  134
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 LCDR3 nucleotide sequence

<400>  134
cagtcagcag acagcagtgg taacagtgct gtg                                    33


<210>  135
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691

<400>  135

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Gly Ala Tyr Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Ser Ser Ile His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser 
                165                 170                 175     


Ser Tyr Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Gly Pro 
    210                 215                 220                 


Gly Tyr Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  136
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 VH

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Ser 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Pro Gly Tyr Tyr Gly Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  137
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 VH nucleotide sequence

<400>  137
gaggttcaac tggtggagag cggtggtggt ctggttcagc cgggtggtag cctgcgtctg       60

agctgcgcag cttctggctt caacctctat tattcttcta tccactgggt gcgtcaggcg      120

ccgggtaaag gcctggaatg ggttgcatct atttattctt cttatggctc tacttcttat      180

gccgatagcg tcaagggccg tttcaccatc agcgcggata ccagcaaaaa caccgcatac      240

ctgcaaatga acagcctgcg tgcggaagat accgccgtct attattgtgc tcgcgttggt      300

ccgggttact acggtattga ctactggggt caaggcaccc tggttaccgt gagcagc         357


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 HCDR1

<400>  138

Gly Phe Asn Leu Tyr Tyr Ser Ser Ile His 
1               5                   10  


<210>  139
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 HCDR1 nucleotide sequence

<400>  139
ggcttcaacc tctattattc ttctatccac                                        30


<210>  140
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 HCDR2

<400>  140

Ile Tyr Ser Ser Tyr Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  141
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 HCDR2 nucleotide sequence

<400>  141
atttattctt cttatggctc tacttcttat gccgatagcg tcaagggc                    48


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 HCDR3

<400>  142

Val Gly Pro Gly Tyr Tyr Gly Ile Asp Tyr 
1               5                   10  


<210>  143
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 HCDR3 nucleotide sequence

<400>  143
gttggtccgg gttactacgg tattgactac                                        30


<210>  144
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 VL

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Gly Ala Tyr Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  145
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 VL nucleotide sequence

<400>  145
gacatccaga tgacccagag cccgagcagc ctgagcgcga gcgttggtga ccgtgttacc       60

attacctgcc gtgcgagcca gagcgttagc agcgcggtgg cgtggtacca gcaaaagccg      120

ggtaaagcgc cgaagctgct gatctatagc gcgagcagcc tgtatagcgg cgttccgagc      180

cgtttcagcg gtagccgtag cggcaccgac tttaccctga ccattagcag cctgcagccg      240

gaagatttcg caacttatta ctgtcagcaa tactacggtg cttacctgat cacgttcgga      300

cagggcacca aagttgagat taaa                                             324


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 LCDR1

<400>  146

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  147
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 LCDR1 nucleotide sequence

<400>  147
cgtgcgagcc agagcgttag cagcgcggtg gcg                                    33


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 LCDR2

<400>  148

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  149
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 LCDR2 nucleotide sequence

<400>  149
agcgcgagca gcctgtatag c                                                 21


<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691 LCDR3

<400>  150

Gln Gln Tyr Tyr Gly Ala Tyr Leu Ile Thr 
1               5                   10  


<210>  151
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS148691 LCDR3 nucleotide sequence

<400>  151
cagcaatact acggtgctta cctgatcacg                                        30


<210>  152
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167821

<400>  152

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Ser Thr Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Ile Tyr Ile Gly Ser Gly Arg Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Asp Val Asp Pro Tyr Glu Ser Ser Trp Ser Arg Gly Leu Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  153
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167821 nucleotide sequence

<400>  153
caggtgaggt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggacg cacctacagt acttactgca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgccact atttatattg gtagtggtag gacatattat      180

gtcgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacgctgtat      240

ctgcaaatga acaatctgaa acctgaggac actgccatgt actactgtac ggcagatgta      300

gacccgtacg aaagtagctg gtcaaggggc cttggttact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167821 HCDR1

<400>  154

Thr Tyr Cys Met Gly 
1               5   


<210>  155
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167821 HCDR1 nucleotide sequence

<400>  155
acttactgca tgggc                                                        15


<210>  156
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167821 HCDR2

<400>  156

Ile Gly Ser Gly Arg Thr Tyr Tyr Val Asp Ser Val Lys Gly 
1               5                   10                  


<210>  157
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167821 HCDR2 nucleotide sequence

<400>  157
attggtagtg gtaggacata ttatgtcgac tccgtgaagg gc                          42


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167821 HCDR3

<400>  158

Asp Val Asp Pro Tyr Glu Ser Ser Trp Ser Arg Gly Leu Gly Tyr 
1               5                   10                  15  


<210>  159
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167821 HCDR3 nucleotide sequence

<400>  159
gatgtagacc cgtacgaaag tagctggtca aggggccttg gttac                       45


<210>  160
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167830

<400>  160

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Glu Tyr Met Asn 
            20                  25                  30          


Arg Arg Phe Cys Met Gly Trp Phe Arg Gln Ala Ser Gly Lys Glu Arg 
        35                  40                  45              


Glu Gly Val Ala Val Val Tyr Ile Gly Gly Gly Arg Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Thr Ala Asp Val Asp Pro Tyr Glu Ser Ser Trp Ser Arg 
            100                 105                 110         


Asp Leu Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  161
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167830 nucleotide sequence

<400>  161
caggtgaagt tggtggagtc tgggggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctcgcag ctctgaatac atgaatagac gattctgcat gggctggttc      120

cgccaggctt cagggaagga gcgcgagggg gtcgcagtgg tttatattgg tggtggtagg      180

acatattatg ccgactccgt gaagggccga ttcaccatct cccaagacaa cgccaagaac      240

acgctgtatc tgcaaatgaa caatctgaaa cctgaggaca ctgccatgta ctactgtacg      300

gcagatgtag acccgtacga aagtagctgg tcaagggacc ttggttactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167830 HCDR1

<400>  162

Met Asn Arg Arg Phe Cys Met Gly 
1               5               


<210>  163
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167830 HCDR1 nucleotide sequence

<400>  163
atgaatagac gattctgcat gggc                                              24


<210>  164
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167830 HCDR2

<400>  164

Ile Gly Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  


<210>  165
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167830 HCDR2 nucleotide sequence

<400>  165
attggtggtg gtaggacata ttatgccgac tccgtgaagg gc                          42


<210>  166
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167830 HCDR3

<400>  166

Asp Val Asp Pro Tyr Glu Ser Ser Trp Ser Arg Asp Leu Gly Tyr 
1               5                   10                  15  


<210>  167
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS167830 HCDR3 nucleotide sequence

<400>  167
gatgtagacc cgtacgaaag tagctggtca agggaccttg gttac                       45


<210>  168
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VH1

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  169
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VH2

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  170
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1

<400>  170

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  171
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL2

<400>  171

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  172
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723/AS179732 VH1

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  173
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723/AS179732 VH1g1

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  174
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723/AS179732 VH1g1-N73Y

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  175
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 VL1

<400>  175

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Asn Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Lys Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  176
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 VL1g1

<400>  176

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Asn Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Lys Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  177
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 VL1

<400>  177

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  178
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 VL1g1

<400>  178

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  179
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VH1

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ala Ser Gly Tyr Gly Gly Ser Trp Trp Gly Asp Ala Thr 
            100                 105                 110         


Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  180
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VH1g1

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ala Ser Gly Tyr Gly Gly Ser Trp Trp Gly Asp Ala Thr 
            100                 105                 110         


Leu Asp Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  181
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VL1

<400>  181

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Gly Gly Tyr Tyr Val Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Leu Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Asn Ser Ala Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  182
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VL2

<400>  182

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Gln Gly Gly Gly Tyr Tyr Val Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Leu Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Ala Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Asn Ser Ala Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  183
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1

<400>  183

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  184
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1 nucleotide sequence

<400>  184
cagagcgccc tgacccagcc taggtctgtg agcggctccc caggccagtc tgtgaccatc       60

agctgcgcag gaacaagctc cgacgtggga tctgagaact acgtgagctg gtatcagcag      120

cacccaggca aggcccccaa gctgatgatc taccaggtga acaagagggc cagcggcgtg      180

ccagatcgct tctctggcag caagtccggc aataccgcct ccctgacaat ctctggactg      240

caggcagagg acgaggcaga ttactattgc gcctcctatc gctctagcga ccacaatatc      300

gtgtttggcg gcggcaccaa gctgacagtg ctgggaggag gaggatccgg aggaggaggc      360

tctggcggcg gcggcagcga ggtgcagctg gtggagagcg gcggcggcct ggtgcagccc      420

ggcggcagcc tgcggctgtc ctgtgccgcc tctggcttca ccttttcctc ttacgcaatg      480

tcctgggtga gacaggcacc aggcaaggga ctggagtggg tgagcaccat caactccggc      540

acaggctctc cttactatgc cgactctgtg aagggccggt tcaccatcag cagagataac      600

tccaagaata cactgtacct gcagatgaac tccctgcggg ccgaggatac agccgtgtac      660

tattgtgcca agaatttctt tgacggctct tggtttctgg gcccccctgc catggattat      720

tggggccagg gcaccctggt gacagtgagc tcc                                   753


<210>  185
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 VL1g1VH1g1-N73Y

<400>  185

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Asn Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Lys Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  186
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179723 VL1g1VH1g1-N73Y nucleotide sequence

<400>  186
caatccgtgc tgacacagcc ccccagcgcc tctggcaccc caggccagag agtgaccatc       60

agctgtagcg gaagcagcaa caacatcggc ggcaactacg tgaactggta ccagcagctg      120

cctggaaccg ctcctaagct gctgatctac gacaacaaga acagacctag cggcgtgcct      180

gatcggttca gcggctccaa gtccggcaca tccgcttctc tggccatctc tggcctgcaa      240

tccgaggacg aggccgacta ctattgcgcc tcttgggacg acagcctgtc tgctgtggtg      300

ttcggcggcg gcaccaagct gaccgtgctg ggcggtggag gctctggcgg cggcggctct      360

ggcggcggag gcagcgaggt gcagctggtg gaaagcggcg gcggactggt gcagcctggc      420

ggatctctga gactgagctg cgccgcttct ggatttacct tcctgaacta cgccatgagc      480

tgggtgcggc aggcccctgg caaaggcctg gaatgggtca gctccaacag cggcgctggc      540

tccacctact acgccgattc tgtgaagggc agattcacaa tctcccggga ctacagcaaa      600

aatacactgt acctgcagat gaactccctc agagccgagg ataccgccgt gtactactgc      660

gccaagggca ccaacgtggg ctcttggtcc agcctgcact actggggtca gggcaccctg      720

gtcaccgtgt ccagt                                                       735


<210>  187
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 VL1g1VH1g1-N73Y

<400>  187

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  188
<211>  736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS179732 VL1g1VH1g1-N73Y nucleotide sequence

<400>  188
caatccgtgc tgacacagcc tccatctgcc tctggcaccc ccggacagag agtgaccatc       60

tcctgcagcg gcagctcctc taacatcggc ggcaactacg tgaactggta ccagcagctg      120

cctggaacag ctcccaagct gctgatctac gacaacagca accgggctag tggcgtgcct      180

gatagatttt ctggctccaa gtccggcacc tccgcttctc tggccatctc cggcctgcag      240

agcgaggacg aggccgacta ctactgtgcc agctgggacg actctctgtc tggcgccgtg      300

ttcggcggag gcaccaagct gaccgtgctg ggcggcggag gatctggagg cggcggttct      360

ggcggaggcg gctccgaggt gcagctggtg gaaagcggcg gcggcctcgt ccaacctggc      420

ggctctctgc ggctgtcctg cgccgcttct ggcttcacct tcctcaacta cgccatgagc      480

tgggtgcggc aggcccctgg caaaggcctg gaatgggtca gcagcaatag cggcgctggc      540

agcacctact atgccgatag cgtgaagggt agattcacca tctctagaga ttatagcaag      600

aacaccctgt acctgcagat gaacagcctg agagccgagg acaccgccgt gtactactgc      660

gccaagggca ccaacgtggg ctcctggtcc agcctgcact actggggcca gggcacactg      720

gtgacagtgt cctccg                                                      736


<210>  189
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VL1VH1

<400>  189

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Gly Gly Tyr Tyr Val Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Leu Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Asn Ser Ala Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Asn Ser Gly Gly Gly 
                165                 170                 175     


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ala Ala Ser Gly Tyr Gly 
    210                 215                 220                 


Gly Ser Trp Trp Gly Asp Ala Thr Leu Asp Ala Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  190
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AS190259 VL1VH1 nucleotide sequence

<400>  190
agctccgaac tgacccagga ccccgccgtg tccgtggccc tgggacagac cgtgcggatc       60

acctgtcagg gcggcggcta ctacgtgaac tggtaccagc agaagcctgg ccaggctcct      120

gtgctggtga tctacctgaa caccaacaga cctagcggca tccccgacag attctctggc      180

tcttctagcg gcaataccgc cagcctcacc attaccggcg cccaggccga agatgaggcc      240

gactactact gccagagcgc cgacagcagc ggaaattctg ctgtgttcgg cggcggcacc      300

aagctgacag ttctgggcgg aggtggcagc ggcggcggcg gcagcggcgg cggcggcagc      360

gaggtgcagc tggtcgagag cggcggcgga ctggtgcaac ctggcggcag cctgagactg      420

agctgcgctg cctccggctt tacattcagc agctacgcca tgagctgggt ccggcaggct      480

ccaggaaaag gcctggaatg ggtgtctgcc atcaacagcg gcggaggctc tacatactac      540

gccgacagcg tgaagggcag attcaccatc agcagagata actctaagaa cacactgtac      600

ctgcaaatga acagcctgcg ggccgaggac accgccgtgt actattgcgc caaggccgcc      660

tccggatatg gcggaagctg gtggggagat gcaacactgg acgcctgggg ccagggcaca      720

ctggtgaccg tgtccagc                                                    738


<210>  191
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98V

<400>  191

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Val Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  192
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98T

<400>  192

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Thr Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  193
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98Q

<400>  193

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  194
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98P

<400>  194

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Pro Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  195
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98I

<400>  195

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  196
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98F

<400>  196

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  197
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98A

<400>  197

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ala Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  198
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLE32W

<400>  198

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Trp 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  199
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG56Y

<400>  199

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  200
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG56N

<400>  200

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  201
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG56F

<400>  201

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Phe Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  202
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57R

<400>  202

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Arg Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  203
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57Q

<400>  203

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Gln Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  204
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57M

<400>  204

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  205
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57K

<400>  205

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  206
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57H

<400>  206

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  207
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108S

<400>  207

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  208
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108N

<400>  208

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asn Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  209
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108M

<400>  209

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Met Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  210
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108E

<400>  210

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Glu Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  211
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108D

<400>  211

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  212
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108A

<400>  212

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  213
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  01-AS170036 VL1VH1-56Y98F

<400>  213

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  214
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  02-AS170036 VL1VH1-56Y98I

<400>  214

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  215
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  03-AS170036 VL1VH1-56Y98Q

<400>  215

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  216
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  04-AS170036 VL1VH1-56N98F

<400>  216

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  217
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  05-AS170036 VL1VH1-56N98I

<400>  217

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  218
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  06-AS170036 VL1VH1-56N98Q

<400>  218

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  219
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  07-AS170036 VL1VH1-57H98F

<400>  219

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  220
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  08-AS170036 VL1VH1-57H98I

<400>  220

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  221
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  09-AS170036 VL1VH1-57H98Q

<400>  221

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  222
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-AS170036 VL1VH1-57K98F

<400>  222

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  223
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11-AS170036 VL1VH1-57K98I

<400>  223

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  224
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-AS170036 VL1VH1-57K98Q

<400>  224

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  225
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13-AS170036 VL1VH1-57M98F

<400>  225

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  226
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14-AS170036 VL1VH1-57M98I

<400>  226

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  227
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15-AS170036 VL1VH1-57M98Q

<400>  227

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  228
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16-AS170036 VL1VH1-56Y108A

<400>  228

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  229
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  17-AS170036 VL1VH1-56Y108D

<400>  229

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  230
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18-AS170036 VL1VH1-56Y108S

<400>  230

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  231
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  19-AS170036 VL1VH1-56N108A

<400>  231

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  232
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20-AS170036 VL1VH1-56N108D

<400>  232

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  233
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21-AS170036 VL1VH1-56N108S

<400>  233

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  234
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  22-AS170036 VL1VH1-57H108A

<400>  234

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  235
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23-AS170036 VL1VH1-57H108D

<400>  235

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  236
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  24-AS170036 VL1VH1-57H108S

<400>  236

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  237
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  25-AS170036 VL1VH1-57K108A

<400>  237

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  238
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26-AS170036 VL1VH1-57K108D

<400>  238

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  239
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  27-AS170036 VL1VH1-57K108S

<400>  239

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  240
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  28-AS170036 VL1VH1-57M108A

<400>  240

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  241
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29-AS170036 VL1VH1-57M108D

<400>  241

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  242
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30-AS170036 VL1VH1-57M108S

<400>  242

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  243
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31-AS170036 VL1VH1-98F108A

<400>  243

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  244
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  32-AS170036 VL1VH1-98F108D

<400>  244

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  245
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  33-AS170036 VL1VH1-98F108S

<400>  245

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  246
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34-AS170036 VL1VH1-98I108A

<400>  246

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  247
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  35-AS170036 VL1VH1-98I108D

<400>  247

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  248
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-AS170036 VL1VH1-98I108S

<400>  248

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  249
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37-AS170036 VL1VH1-98Q108A

<400>  249

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  250
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  38-AS170036 VL1VH1-98Q108D

<400>  250

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  251
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  39-AS170036 VL1VH1-98Q108S

<400>  251

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  252
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  40-AS170036 VL1VH1-56Y98F108A

<400>  252

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  253
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41-AS170036 VL1VH1-56Y98F108D

<400>  253

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  254
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42-AS170036 VL1VH1-56Y98F108S

<400>  254

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  255
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43-AS170036 VL1VH1-56Y98I108A

<400>  255

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  256
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  44-AS170036 VL1VH1-56Y98I108D

<400>  256

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  257
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45-AS170036 VL1VH1-56Y98I108S

<400>  257

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  258
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46-AS170036 VL1VH1-56Y98Q108A

<400>  258

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  259
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47-AS170036 VL1VH1-56Y98Q108D

<400>  259

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  260
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  48-AS170036 VL1VH1-56Y98Q108S

<400>  260

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  261
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49-AS170036 VL1VH1-56N98F108A

<400>  261

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  262
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50-AS170036 VL1VH1-56N98F108D

<400>  262

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  263
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51-AS170036 VL1VH1-56N98F108S

<400>  263

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  264
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52-AS170036 VL1VH1-56N98I108A

<400>  264

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  265
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53-AS170036 VL1VH1-56N98I108D

<400>  265

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  266
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54-AS170036 VL1VH1-56N98I108S

<400>  266

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  267
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  55-AS170036 VL1VH1-56N98Q108A

<400>  267

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  268
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  56-AS170036 VL1VH1-56N98Q108D

<400>  268

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  269
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  57-AS170036 VL1VH1-56N98Q108S

<400>  269

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  270
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  58-AS170036 VL1VH1-57H98F108A

<400>  270

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  271
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  59-AS170036 VL1VH1-57H98F108D

<400>  271

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  272
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60-AS170036 VL1VH1-57H98F108S

<400>  272

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  273
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  61-AS170036 VL1VH1-57H98I108A

<400>  273

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  274
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-AS170036 VL1VH1-57H98I108D

<400>  274

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  275
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  63-AS170036 VL1VH1-57H98I108S

<400>  275

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  276
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  64-AS170036 VL1VH1-57H98Q108A

<400>  276

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  277
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  65-AS170036 VL1VH1-57H98Q108D

<400>  277

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  278
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  66-AS170036 VL1VH1-57H98Q108S

<400>  278

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  279
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  67-AS170036 VL1VH1-57K98F108A

<400>  279

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  280
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68-AS170036 VL1VH1-57K98F108D

<400>  280

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  281
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  69-AS170036 VL1VH1-57K98F108S

<400>  281

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  282
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  70-AS170036 VL1VH1-57K98I108A

<400>  282

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  283
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71-AS170036 VL1VH1-57K98I108D

<400>  283

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  284
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  72-AS170036 VL1VH1-57K98I108S

<400>  284

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  285
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  73-AS170036 VL1VH1-57K98Q108A

<400>  285

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  286
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  74-AS170036 VL1VH1-57K98Q108D

<400>  286

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  287
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  75-AS170036 VL1VH1-57K98Q108S

<400>  287

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  288
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  76-AS170036 VL1VH1-57M98F108A

<400>  288

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  289
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  77-AS170036 VL1VH1-57M98F108D

<400>  289

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  290
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  78-AS170036 VL1VH1-57M98F108S

<400>  290

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  291
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  79-AS170036 VL1VH1-57M98I108A

<400>  291

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  292
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  80-AS170036 VL1VH1-57M98I108D

<400>  292

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  293
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  81-AS170036 VL1VH1-57M98I108S

<400>  293

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  294
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  82-AS170036 VL1VH1-57M98Q108A

<400>  294

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  295
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  83-AS170036 VL1VH1-57M98Q108D

<400>  295

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  296
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  84-AS170036 VL1VH1-57M98Q108S

<400>  296

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  297
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036-TCE

<400>  297

Gln Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Lys Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
305                 310                 315                 320 


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
                325                 330                 335     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                405                 410                 415     


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            420                 425                 430         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
        435                 440                 445             


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
                485                 490                 495     


Glu Leu Lys His His His His His His 
            500                 505 


<210>  298
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-TCE

<400>  298

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
            260                 265                 270         


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
        275                 280                 285             


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
    290                 295                 300                 


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
305                 310                 315                 320 


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
                325                 330                 335     


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            340                 345                 350         


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                405                 410                 415     


Arg Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            420                 425                 430         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser 
        435                 440                 445             


Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    450                 455                 460                 


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
                485                 490                 495     


Glu Leu Lys His His His His His His 
            500                 505 


<210>  299
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723-TCE

<400>  299

Gln Ala Gly Leu Thr Gln Pro Pro Ser Met Ser Gly Ser Pro Arg Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Asn Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Lys Asn Arg Pro Ser Gly Val Pro Glu Gln Ile Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ala Lys Asn Val Val Tyr Leu Gln Leu Asn 
        195                 200                 205             


Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Gln 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln 
                245                 250                 255     


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
            260                 265                 270         


Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
        275                 280                 285             


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    290                 295                 300                 


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
305                 310                 315                 320 


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
                325                 330                 335     


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
            340                 345                 350         


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
        355                 360                 365             


Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
385                 390                 395                 400 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
                405                 410                 415     


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
            420                 425                 430         


Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe 
        435                 440                 445             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    450                 455                 460                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
465                 470                 475                 480 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys His His His 
                485                 490                 495     


His His His 
            


<210>  300
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732-TCE

<400>  300

Asn Phe Met Leu Thr Gln Pro Pro Ser Met Ser Gly Ser Pro Arg Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Asn Arg Ala Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Ser Ser Ala Ser Leu Thr Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ala Lys Asn Val Val Tyr Leu Gln Leu Asn 
        195                 200                 205             


Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Gln 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln 
                245                 250                 255     


Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys 
            260                 265                 270         


Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys 
        275                 280                 285             


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    290                 295                 300                 


Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu 
305                 310                 315                 320 


Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
                325                 330                 335     


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
            340                 345                 350         


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
        355                 360                 365             


Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
385                 390                 395                 400 


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val 
                405                 410                 415     


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
            420                 425                 430         


Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe 
        435                 440                 445             


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
    450                 455                 460                 


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
465                 470                 475                 480 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys His His His 
                485                 490                 495     


His His His 
            


<210>  301
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Blinatumomab-TCE

<400>  301

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 
145                 150                 155                 160 


Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 
                165                 170                 175     


Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
        275                 280                 285             


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
305                 310                 315                 320 


Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met 
                325                 330                 335     


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
                405                 410                 415     


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly 
            420                 425                 430         


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly 
        435                 440                 445             


Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
    450                 455                 460                 


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
                485                 490                 495     


Leu Lys His His His His His His 
            500                 


<210>  302
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-TCE-HLE

<400>  302

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  303
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 VL1g1VH1g1-N73Y-TCE-HLE

<400>  303

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Asn Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Lys Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
    290                 295                 300                 


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg 
305                 310                 315                 320 


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                325                 330                 335     


Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
            340                 345                 350         


Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
385                 390                 395                 400 


Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
                405                 410                 415     


Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
            420                 425                 430         


Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala 
        435                 440                 445             


Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
    450                 455                 460                 


Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
465                 470                 475                 480 


Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Thr Val Leu Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys 
                565                 570                 575     


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val 
            580                 585                 590         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
625                 630                 635                 640 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
                725                 730                 735     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
        755                 760                 765             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    770                 775                 780                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
785                 790                 795                 800 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                805                 810                 815     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            820                 825                 830         


Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr 
        835                 840                 845             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    850                 855                 860                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
865                 870                 875                 880 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                885                 890                 895     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            900                 905                 910         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        915                 920                 925             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    930                 935                 940                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
945                 950                 955                 960 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                965                 970                 975     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985             


<210>  304
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 VL1g1VH1g1-N73Y-TCE-HLE

<400>  304

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Asn 
                165                 170                 175     


Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Tyr Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Thr 
    210                 215                 220                 


Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser 
    290                 295                 300                 


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg 
305                 310                 315                 320 


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met 
                325                 330                 335     


Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
            340                 345                 350         


Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser 
385                 390                 395                 400 


Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser 
                405                 410                 415     


Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys 
            420                 425                 430         


Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala 
        435                 440                 445             


Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala 
    450                 455                 460                 


Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr 
465                 470                 475                 480 


Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Leu Thr Val Leu Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys 
                565                 570                 575     


Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val 
            580                 585                 590         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
625                 630                 635                 640 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
                725                 730                 735     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
        755                 760                 765             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    770                 775                 780                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
785                 790                 795                 800 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                805                 810                 815     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            820                 825                 830         


Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr 
        835                 840                 845             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    850                 855                 860                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
865                 870                 875                 880 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                885                 890                 895     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            900                 905                 910         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        915                 920                 925             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    930                 935                 940                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
945                 950                 955                 960 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                965                 970                 975     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985             


<210>  305
<211>  989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VL1VH1-TCE-HLE

<400>  305

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Gly Gly Tyr Tyr Val Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Leu Asn Thr 
        35                  40                  45              


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
    50                  55                  60                  


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Asn Ser Ala Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Asn Ser Gly Gly Gly 
                165                 170                 175     


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ala Ala Ser Gly Tyr Gly 
    210                 215                 220                 


Gly Ser Trp Trp Gly Asp Ala Thr Leu Asp Ala Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
                245                 250                 255     


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu 
            260                 265                 270         


Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp 
        275                 280                 285             


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg 
    290                 295                 300                 


Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln 
                325                 330                 335     


Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
            340                 345                 350         


His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro 
385                 390                 395                 400 


Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser 
                405                 410                 415     


Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln 
            420                 425                 430         


Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu 
        435                 440                 445             


Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys 
    450                 455                 460                 


Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr 
465                 470                 475                 480 


Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro 
            500                 505                 510         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        515                 520                 525             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    530                 535                 540                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
545                 550                 555                 560 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                565                 570                 575     


Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr 
            580                 585                 590         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        595                 600                 605             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    610                 615                 620                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
625                 630                 635                 640 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                645                 650                 655     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            660                 665                 670         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        675                 680                 685             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    690                 695                 700                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
705                 710                 715                 720 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                725                 730                 735     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys 
        755                 760                 765             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
    770                 775                 780                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
785                 790                 795                 800 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                805                 810                 815     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            820                 825                 830         


Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu 
        835                 840                 845             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    850                 855                 860                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
865                 870                 875                 880 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                885                 890                 895     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            900                 905                 910         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        915                 920                 925             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    930                 935                 940                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
945                 950                 955                 960 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                965                 970                 975     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985                 


<210>  306
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS148691-TCE-HLE

<400>  306

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Gly Ala Tyr Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Ser Ser Ile His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Ser Ile Tyr Ser 
                165                 170                 175     


Ser Tyr Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Gly Pro 
    210                 215                 220                 


Gly Tyr Tyr Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
    290                 295                 300                 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                325                 330                 335     


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
            340                 345                 350         


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
385                 390                 395                 400 


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
                405                 410                 415     


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
            420                 425                 430         


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
        435                 440                 445             


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
    450                 455                 460                 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
465                 470                 475                 480 


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                485                 490                 495     


Leu Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
                565                 570                 575     


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        755                 760                 765             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    770                 775                 780                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
785                 790                 795                 800 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                805                 810                 815     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
            820                 825                 830         


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
        835                 840                 845             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    850                 855                 860                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
865                 870                 875                 880 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                885                 890                 895     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            900                 905                 910         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        915                 920                 925             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    930                 935                 940                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
945                 950                 955                 960 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                965                 970                 975     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985 


<210>  307
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG56Y-TCE-HLE

<400>  307

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  308
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57K-TCE-HLE

<400>  308

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  309
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57H-TCE-HLE

<400>  309

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  310
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108D-TCE-HLE

<400>  310

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  311
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108A-TCE-HLE

<400>  311

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  312
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56Y98Q-TCE-HLE

<400>  312

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  313
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56N98I-TCE-HLE

<400>  313

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  314
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57K98F-TCE-HLE

<400>  314

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  315
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57M98Q-TCE-HLE

<400>  315

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  316
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56Y108A-TCE-HLE

<400>  316

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  317
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56N108A-TCE-HLE

<400>  317

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  318
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57H108A-TCE-HLE

<400>  318

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  319
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57K108A-TCE-HLE

<400>  319

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  320
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57K108S-TCE-HLE

<400>  320

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp His Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  321
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-98I108A-TCE-HLE

<400>  321

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  322
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56Y98F108A-TCE-HLE

<400>  322

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  323
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56Y98F108S-TCE-HLE

<400>  323

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  324
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56Y98I108A-TCE-HLE

<400>  324

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  325
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56Y98I108S-TCE-HLE

<400>  325

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  326
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56Y98Q108S-TCE-HLE

<400>  326

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  327
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-56N98F108A-TCE-HLE

<400>  327

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  328
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57K98F108A-TCE-HLE

<400>  328

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Phe Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  329
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57K98I108A-TCE-HLE

<400>  329

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Ile Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  330
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57K98Q108S-TCE-HLE

<400>  330

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  331
<211>  994
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-57M98Q108A-TCE-HLE

<400>  331

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                85                  90                  95      


Asp Gln Asn Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
145                 150                 155                 160 


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
                165                 170                 175     


Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys 
        275                 280                 285             


Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Val Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn 
                325                 330                 335     


Thr Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Ile Ser Tyr 
        355                 360                 365             


Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val 
385                 390                 395                 400 


Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val Thr 
                405                 410                 415     


Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly Asn Tyr Pro 
            420                 425                 430         


Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Arg Gly Leu Ile Gly 
        435                 440                 445             


Gly Thr Lys Phe Leu Ala Pro Gly Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Glu Tyr Tyr Cys Val Leu Trp Tyr Ser Asn Arg Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg Cys 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            740                 745                 750         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
        755                 760                 765             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    770                 775                 780                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
785                 790                 795                 800 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                805                 810                 815     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            820                 825                 830         


Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
        835                 840                 845             


Cys Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    850                 855                 860                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
865                 870                 875                 880 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                885                 890                 895     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            900                 905                 910         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        915                 920                 925             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    930                 935                 940                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
945                 950                 955                 960 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                965                 970                 975     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            980                 985                 990         


Gly Lys 
        


<210>  332
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCE-KIH Chain1

<400>  332

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Arg Gly Tyr Gly Asp Tyr Arg Leu Gly Gly Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asp Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  333
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCE-KIH Chain3

<400>  333

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  334
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167821A-AS167821A -TCE-KIH Chain2

<400>  334

Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr Ser Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Thr Ile Tyr Ile Gly Ser Gly Arg Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Asp Val Asp Pro Tyr Glu Ser Ser Trp Ser Arg Gly Leu Gly 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Arg Leu Val Glu Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
                165                 170                 175     


Thr Tyr Ser Thr Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Glu Arg Glu Gly Val Ala Thr Ile Tyr Ile Gly Ser Gly Arg Thr Tyr 
        195                 200                 205             


Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr 
225                 230                 235                 240 


Ala Met Tyr Tyr Cys Thr Ala Asp Val Asp Pro Tyr Glu Ser Ser Trp 
                245                 250                 255     


Ser Arg Gly Leu Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            260                 265                 270         


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        275                 280                 285             


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    290                 295                 300                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
305                 310                 315                 320 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                325                 330                 335     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            340                 345                 350         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        355                 360                 365             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    370                 375                 380                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
385                 390                 395                 400 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                405                 410                 415     


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
            420                 425                 430         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        435                 440                 445             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    450                 455                 460                 


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
465                 470                 475                 480 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Tyr Thr Gln 
                485                 490                 495     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505 


<210>  335
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS167830A-AS167830A -TCE-KIH Chain2

<400>  335

Gln Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Glu Tyr Met Asn 
            20                  25                  30          


Arg Arg Phe Ala Met Gly Trp Phe Arg Gln Ala Ser Gly Lys Glu Arg 
        35                  40                  45              


Glu Gly Val Ala Val Val Tyr Ile Gly Gly Gly Arg Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Thr Ala Asp Val Asp Pro Tyr Glu Ser Ser Trp Ser Arg 
            100                 105                 110         


Asp Leu Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Arg Ser Ser Glu Tyr Met Asn Arg Arg Phe Ala Met Gly Trp Phe 
            180                 185                 190         


Arg Gln Ala Ser Gly Lys Glu Arg Glu Gly Val Ala Val Val Tyr Ile 
        195                 200                 205             


Gly Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    210                 215                 220                 


Ile Ser Gln Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Asn 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Thr Ala Asp Val Asp 
                245                 250                 255     


Pro Tyr Glu Ser Ser Trp Ser Arg Asp Leu Gly Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Gln Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn Arg Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 510     


<210>  336
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723/AS179732 VH1g1 HCDR2

<400>  336

Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  337
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723/AS179732 VH1g1-N73Y HCDR2

<400>  337

Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  338
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179723 VL1g1 LCDR1

<400>  338

Ser Gly Ser Ser Asn Asn Ile Gly Gly Asn Tyr Val Asn 
1               5                   10              


<210>  339
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS179732 VL1g1 LCDR1

<400>  339

Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val Asn 
1               5                   10              


<210>  340
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS190259 VH1g1 HCDR2

<400>  340

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  341
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VH1 HCDR2 Consensus


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X1 is S, A, or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X2 is G, A, D, E, F, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X3 is S, A, D, F, H, K, M, N, Q, R, T, W, or Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X4 is P, A, D, E, F, G, H, K, M, N, Q, R, S, T, V, W, or Y

<400>  341

Thr Ile Asn Xaa Gly Thr Xaa Xaa Xaa Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  342
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VH1 HCDR3 Consensus


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X5 is F, D, H, N, W, or Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X6 is D, A, E, G, I, L, M, N, P, Q, S, T, V, or W

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X7 is W, F, or M

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X8 is F, or W

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X9 is L, A, G, I, M, N, Q, S, T, or V

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X10 is G, A, D, E, F, H, I, L, M, N, Q, R, S, T, V, W, or Y

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  X11 is P, A, N, or T

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X12 is P, A, D, E, G, I, L, N, Q, S, T, or V

<400>  342

Asn Phe Xaa Xaa Gly Ser Xaa Xaa Xaa Xaa Xaa Xaa Ala Met Asp Tyr 
1               5                   10                  15      


<210>  343
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1 LCDR1 Consensus


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X13 is E, A, D, G, H, I, L, M, N, P, Q, S, T, V, W, or Y

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X14 is Y, A, D, E, F, G, H, I, L, M, P, S, T, V, or W

<400>  343

Ala Gly Thr Ser Ser Asp Val Gly Ser Xaa Asn Xaa Val Ser 
1               5                   10                  


<210>  344
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1 LCDR3 Consensus


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X15 is Y, D, F, H, I, L, M, N, Q, T, V, or W

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X16 is D, A, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, or Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X17 is H, A, D, F, G, I, K, L, M, N, P, Q, R, S, T, V, W, or Y

<400>  344

Ala Ser Xaa Arg Ser Ser Xaa Xaa Asn Ile Val 
1               5                   10      


<210>  345
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98V VL CDR3

<400>  345

Ala Ser Tyr Arg Ser Ser Asp Val Asn Ile Val 
1               5                   10      


<210>  346
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98T VL CDR3

<400>  346

Ala Ser Tyr Arg Ser Ser Asp Thr Asn Ile Val 
1               5                   10      


<210>  347
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98Q VL CDR3

<400>  347

Ala Ser Tyr Arg Ser Ser Asp Gln Asn Ile Val 
1               5                   10      


<210>  348
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98P VL CDR3

<400>  348

Ala Ser Tyr Arg Ser Ser Asp Pro Asn Ile Val 
1               5                   10      


<210>  349
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98I VL CDR3

<400>  349

Ala Ser Tyr Arg Ser Ser Asp Ile Asn Ile Val 
1               5                   10      


<210>  350
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98F VL CDR3

<400>  350

Ala Ser Tyr Arg Ser Ser Asp Phe Asn Ile Val 
1               5                   10      


<210>  351
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VLH98A VL CDR3

<400>  351

Ala Ser Tyr Arg Ser Ser Asp Ala Asn Ile Val 
1               5                   10      


<210>  352
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGTSSDVGSWNYVS

<400>  352

Ala Gly Thr Ser Ser Asp Val Gly Ser Trp Asn Tyr Val Ser 
1               5                   10                  


<210>  353
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG56Y VH CDR2

<400>  353

Thr Ile Asn Ser Gly Thr Tyr Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  354
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG56N VH CDR2

<400>  354

Thr Ile Asn Ser Gly Thr Asn Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  355
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG56F VH CDR2

<400>  355

Thr Ile Asn Ser Gly Thr Phe Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  356
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57R VH CDR2

<400>  356

Thr Ile Asn Ser Gly Thr Gly Arg Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  357
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57Q VH CDR2

<400>  357

Thr Ile Asn Ser Gly Thr Gly Gln Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  358
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57M VH CDR2

<400>  358

Thr Ile Asn Ser Gly Thr Gly Met Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  359
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57K VH CDR2

<400>  359

Thr Ile Asn Ser Gly Thr Gly Lys Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  360
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHS57H VH CDR2

<400>  360

Thr Ile Asn Ser Gly Thr Gly His Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  361
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108S VH CDR3

<400>  361

Asn Phe Phe Asp Gly Ser Trp Phe Leu Ser Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  362
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108N VH CDR3

<400>  362

Asn Phe Phe Asp Gly Ser Trp Phe Leu Asn Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  363
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108M VH CDR3

<400>  363

Asn Phe Phe Asp Gly Ser Trp Phe Leu Met Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  364
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108E VH CDR3

<400>  364

Asn Phe Phe Asp Gly Ser Trp Phe Leu Glu Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  365
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108D VH CDR3

<400>  365

Asn Phe Phe Asp Gly Ser Trp Phe Leu Asp Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  366
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 VL1VH1-VHG108A VH CDR3

<400>  366

Asn Phe Phe Asp Gly Ser Trp Phe Leu Ala Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  367
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934

<400>  367

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Pro Val Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Met Ser Gly Ser Pro Arg Gln Ser Val Thr Ile Ser Cys Thr Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Asn Asn Tyr Val Asn Trp Tyr Gln His Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn Ser Ala Arg Ala Ser 
            180                 185                 190         


Gly Val Pro Glu Arg Phe Ser Gly Ser Lys Ser Asp Asn Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys 
    210                 215                 220                 


Glu Ser Trp Asp Gly Ser Arg Arg Ala Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


His Leu Thr Val Leu 
                245 


<210>  368
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VH

<400>  368

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  369
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VL

<400>  369

Gln Pro Val Leu Thr Gln Pro Pro Ser Met Ser Gly Ser Pro Arg Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Ser Ala Arg Ala Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Asp Asn Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Glu Ser Trp Asp Gly Ser Arg 
                85                  90                  95      


Arg Ala Val Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110 


<210>  370
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VH CDR1

<400>  370

Gly Phe Thr Phe Ser Ile Tyr Ala Met Ser 
1               5                   10  


<210>  371
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VH CDR2

<400>  371

Ser Asn Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  372
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VH CDR3

<400>  372

Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr 
1               5                   10          


<210>  373
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VL CDR1

<400>  373

Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Asn 
1               5                   10              


<210>  374
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VL CDR2

<400>  374

Asp Asn Ser Ala Arg Ala Ser 
1               5           


<210>  375
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176934 VL CDR3

<400>  375

Glu Ser Trp Asp Gly Ser Arg Arg Ala Val Val 
1               5                   10      


<210>  376
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951

<400>  376

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Glu Ala Ser Gly Phe Thr Phe Leu Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser His Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu Leu Thr Gln Pro Ser Ala 
    130                 135                 140                 


Val Ser Val Ser Leu Gly Glu Thr Ala Arg Ile Thr Cys Gln Gly Gly 
145                 150                 155                 160 


Asn Phe Glu Ser Tyr Tyr Ser Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Val Leu Val Ile Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile 
            180                 185                 190         


Ala Glu Arg Phe Ser Gly Ser Ser Ser Gly Gly Thr Ala Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Ala Gln Ala Glu Asp Glu Ala Ser Tyr Tyr Cys Gln Ser 
    210                 215                 220                 


Ala Asp Ser Ser Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
225                 230                 235                 240 


<210>  377
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VH

<400>  377

Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Glu Ala Ser Gly Phe Thr Phe Leu Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser His Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Gly Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  378
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VL

<400>  378

Ser Ser Glu Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gln Gly Gly Asn Phe Glu Ser Tyr Tyr Ser 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Ala Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Gly Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Ser Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Ile Val Phe 
                85                  90                  95      


Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105 


<210>  379
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VH CDR1

<400>  379

Gly Phe Thr Phe Leu Asn Tyr Ala Met Ser 
1               5                   10  


<210>  380
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VH CDR2

<400>  380

Ser His Ser Gly Ala Gly Ser Thr Tyr Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  381
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VH CDR3

<400>  381

Gly Thr Asn Val Gly Ser Trp Ser Ser Leu His Tyr 
1               5                   10          


<210>  382
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VL CDR1

<400>  382

Gln Gly Gly Asn Phe Glu Ser Tyr Tyr Ser Ser 
1               5                   10      


<210>  383
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VL CDR2

<400>  383

Lys Asp Ser Glu Arg Pro Ser 
1               5           


<210>  384
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176951 VL CDR3

<400>  384

Gln Ser Ala Asp Ser Ser Ile Val 
1               5               


<210>  385
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992

<400>  385

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ser Asp Gly Ser Asn Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Leu Arg Ser Trp Phe Ser Thr Val Asn Ala Leu Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu Leu Thr Gln 
    130                 135                 140                 


Pro Ala Ala Val Ser Val Ser Leu Gly Glu Thr Ala Arg Ile Thr Cys 
145                 150                 155                 160 


Gln Gly Gly Asn Phe Gly Ser Tyr Tyr Ala Ser Trp His Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Val Leu Ile Ile Tyr Gly Asn Ser Asp Arg Pro 
            180                 185                 190         


Phe Gly Ile Pro Glu Arg Phe Ser Gly Ser Ala Ser Gly Gly Thr Ala 
        195                 200                 205             


Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp Asp Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gln Ser Tyr Asp Ser Ser Ala Asn Ala Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


His Leu Thr Val Leu 
                245 


<210>  386
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VH

<400>  386

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ser Asp Gly Ser Asn Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Leu Arg Ser Trp Phe Ser Thr Val Asn Ala Leu Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  387
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VL

<400>  387

Ser Ser Glu Leu Thr Gln Pro Ala Ala Val Ser Val Ser Leu Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gln Gly Gly Asn Phe Gly Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp His Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Tyr 
        35                  40                  45              


Gly Asn Ser Asp Arg Pro Phe Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Gly Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Ala Asn Ala 
                85                  90                  95      


Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105         


<210>  388
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VH CDR1

<400>  388

Gly Phe Thr Phe Ser Arg His Tyr Met Ser 
1               5                   10  


<210>  389
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VH CDR2

<400>  389

Ser Ile Tyr Ser Asp Gly Ser Asn Thr Tyr Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  390
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VH CDR3

<400>  390

Asp Leu Arg Ser Trp Phe Ser Thr Val Asn Ala Leu Asp Ala 
1               5                   10                  


<210>  391
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VL CDR1

<400>  391

Gln Gly Gly Asn Phe Gly Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  392
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VL CDR2

<400>  392

Gly Asn Ser Asp Arg Pro Phe 
1               5           


<210>  393
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS176992 VL CDR3

<400>  393

Gln Ser Tyr Asp Ser Ser Ala Asn Ala Val 
1               5                   10  


<210>  394
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005

<400>  394

Gln Val Gln Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
1               5                   10                  15      


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr Thr Gly Gly 
        35                  40                  45              


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
65                  70                  75                  80  


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Ile Val Val Ala 
                85                  90                  95      


Thr Gly Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
        115                 120                 125             


Ser Glu Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln Thr 
    130                 135                 140                 


Ala Arg Ile Thr Cys Gln Gly Gly Asn Leu Gly Ser Ser Tyr Val His 
145                 150                 155                 160 


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
                165                 170                 175     


Asp Asp Ser Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser 
            180                 185                 190         


Ser Gly Gly Ile Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp 
        195                 200                 205             


Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Tyr Ala Met 
    210                 215                 220                 


Phe Gly Gly Gly Thr His Leu Thr Val Leu 
225                 230                 


<210>  395
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VH

<400>  395

Gln Val Gln Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
1               5                   10                  15      


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser Trp Val Arg Gln 
            20                  25                  30          


Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Tyr Thr Gly Gly 
        35                  40                  45              


Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Lys Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys 
65                  70                  75                  80  


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Ile Val Val Ala 
                85                  90                  95      


Thr Gly Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


<210>  396
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VL

<400>  396

Ser Ser Glu Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gln Gly Gly Asn Leu Gly Ser Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Asp Ser Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Gly Ile Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Tyr Ala 
                85                  90                  95      


Met Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105         


<210>  397
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VH CDR1

<400>  397

Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser 
1               5                   10  


<210>  398
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VH CDR2

<400>  398

Ser Ile Tyr Thr Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  399
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VH CDR3

<400>  399

Ala Ile Val Val Ala Thr Gly Phe Gly Tyr 
1               5                   10  


<210>  400
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VL CDR1

<400>  400

Gln Gly Gly Asn Leu Gly Ser Ser Tyr Val His 
1               5                   10      


<210>  401
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VL CDR2

<400>  401

Gly Asp Asp Ser Arg Pro Ser 
1               5           


<210>  402
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS177005 VL CDR3

<400>  402

Gln Ser Tyr Asp Ser Ser Asn Tyr Ala Met 
1               5                   10  


<210>  403
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030

<400>  403

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
                85                  90                  95      


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Gly Leu Thr Gln 
    130                 135                 140                 


Pro Ser Ser Val Ser Gly Thr Pro Gly Gln Thr Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ala Gly Thr Ser Ser Asp Val Gly Ser Gly Asp Tyr Val Ser Trp Tyr 
                165                 170                 175     


Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gln Val Asn 
            180                 185                 190         


Lys Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ala Ser Gly 
        195                 200                 205             


Asn Met Ala Ser Met Thr Ile Ser Gly Leu Gln Ser Ala Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gly Ser Tyr Arg Ser Gly Asp Asn Ala Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr His Leu Thr Val Leu Glu Val 
                245                 250 


<210>  404
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VH

<400>  404

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
                85                  90                  95      


Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  405
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VL

<400>  405

Gln Ala Gly Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Gly 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ala Ser Gly Asn Met Ala Ser Met Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Arg Ser Gly 
                85                  90                  95      


Asp Asn Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Glu Val 
            100                 105                 110         


<210>  406
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VH CDR1

<400>  406

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  407
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VH CDR2

<400>  407

Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  408
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VH CDR3

<400>  408

Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro Pro Ala Met Asp Tyr 
1               5                   10                  15      


<210>  409
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VL CDR1

<400>  409

Ala Gly Thr Ser Ser Asp Val Gly Ser Gly Asp Tyr Val Ser 
1               5                   10                  


<210>  410
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VL CDR2

<400>  410

Gln Val Asn Lys Arg Ala Ser 
1               5           


<210>  411
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170030 VL CDR3

<400>  411

Gly Ser Tyr Arg Ser Gly Asp Asn Ala Val 
1               5                   10  


<210>  412
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBZ CAR signal peptide

<400>  412

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  413
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BBZ CAR

<400>  413

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
65                  70                  75                  80  


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                85                  90                  95      


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            100                 105                 110         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
        115                 120                 125             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    130                 135                 140                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
145                 150                 155                 160 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                165                 170                 175     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            180                 185                 190         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        195                 200                 205             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220             


<210>  414
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3e CAR signal peptide

<400>  414

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln 
            20          


<210>  415
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3e CAR

<400>  415

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
1               5                   10                  15      


Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val Ser 
            20                  25                  30          


Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly Ser 
        35                  40                  45              


Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu Asp 
    50                  55                  60                  


Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu Phe 
65                  70                  75                  80  


Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser 
                85                  90                  95      


Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val Cys 
            100                 105                 110         


Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val Ile 
        115                 120                 125             


Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr Trp 
    130                 135                 140                 


Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly 
145                 150                 155                 160 


Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val 
                165                 170                 175     


Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr 
            180                 185                 190         


Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200 


<210>  416
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036 CAR

<400>  416

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly Pro 
        115                 120                 125             


Pro Ala Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Ile Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln Thr 
                165                 170                 175     


Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu Asn 
            180                 185                 190         


Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly Leu Gln 
225                 230                 235                 240 


Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser Asp 
                245                 250                 255     


His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Ala Val 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  417
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036-CD3e

<400>  417

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala 
            100                 105                 110         


Met Tyr Tyr Cys Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu Gly 
        115                 120                 125             


Pro Pro Ala Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Ile Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gln Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly Gln 
                165                 170                 175     


Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser Glu 
            180                 185                 190         


Asn Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly Leu 
225                 230                 235                 240 


Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser Ser 
                245                 250                 255     


Asp His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu Ala 
            260                 265                 270         


Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
    290                 295                 300                 


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
305                 310                 315                 320 


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
                325                 330                 335     


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
            340                 345                 350         


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
        355                 360                 365             


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
    370                 375                 380                 


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val 
385                 390                 395                 400 


Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
                405                 410                 415     


Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala 
            420                 425                 430         


Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro 
        435                 440                 445             


Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu 
    450                 455                 460                 


Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
465                 470             


<210>  418
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036-28Z

<400>  418

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu 
        115                 120                 125             


Gly Pro Pro Ala Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Ile 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly 
                165                 170                 175     


Gln Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser 
            180                 185                 190         


Glu Asn Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly 
225                 230                 235                 240 


Leu Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser 
                245                 250                 255     


Ser Asp His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            260                 265                 270         


Ala Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  419
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036-28BBZ

<400>  419

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu 
        115                 120                 125             


Gly Pro Pro Ala Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Ile 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly 
                165                 170                 175     


Gln Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser 
            180                 185                 190         


Glu Asn Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly 
225                 230                 235                 240 


Leu Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser 
                245                 250                 255     


Ser Asp His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            260                 265                 270         


Ala Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
385                 390                 395                 400 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                405                 410                 415     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            420                 425                 430         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        435                 440                 445             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    450                 455                 460                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
465                 470                 475                 480 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                485                 490                 495     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            500                 505                 510         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        515                 520                 525             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540     


<210>  420
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS170036-28Z-T2

<400>  420

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Thr Ile Asn Ser Gly Thr Gly Ser Pro Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Lys Asn Phe Phe Asp Gly Ser Trp Phe Leu 
        115                 120                 125             


Gly Pro Pro Ala Met Asp Tyr Trp Gly Lys Gly Thr Leu Val Thr Ile 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gln Leu Val Leu Thr Gln Pro Ser Ser Val Ser Gly Thr Pro Gly 
                165                 170                 175     


Gln Thr Val Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Ser 
            180                 185                 190         


Glu Asn Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Gln Val Asn Lys Arg Ala Ser Gly Ile Ala Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Met Thr Ile Ser Gly 
225                 230                 235                 240 


Leu Gln Ser Ala Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Ser 
                245                 250                 255     


Ser Asp His Asn Ile Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            260                 265                 270         


Ala Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
        275                 280                 285             


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
    290                 295                 300                 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
            340                 345                 350         


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
        355                 360                 365             


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
    370                 375                 380                 


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp 
            500                 505                 510         


Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn 
        515                 520                 525             


Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys 
    530                 535                 540                 


Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr 
545                 550                 555                 560 


Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr 
                565                 570                 575     


Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala 
            580                 585                 590         


Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln 
        595                 600                 605             


Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu 
    610                 615                 620                 


Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg 
625                 630                 635                 640 


Ala Ala Ile Lys Ser 
                645 


<210>  421
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker1

<400>  421

Gly Gly Gly Gly Ser 
1               5   


<210>  422
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker2

<400>  422

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  423
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-Hinge-TM amino acid sequence

<400>  423

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  424
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 Hinge amino acid sequence

<400>  424

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  425
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 TM amino acid sequence

<400>  425

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  426
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge amino acid sequence

<400>  426

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  427
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 TM amino acid sequence

<400>  427

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  428
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain amino acid sequence

<400>  428

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  429
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-4-1BB co-stimulatory domain amino acid sequence

<400>  429

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        35                  40                  45              


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    50                  55                  60                  


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
65                  70                  75                  80  


Cys Glu Leu 
            


<210>  430
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular signaling domain amino acid sequence

<400>  430

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  431
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta amino acid sequence

<400>  431

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  432
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ET1402L1 CAR

<400>  432

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Thr Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ser Phe Pro Asn Tyr Trp Ile Thr Trp Val Arg Gln Met Ser Gly Gly 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Arg Ile Asp Pro Gly Asp Ser Tyr Thr Thr 
65                  70                  75                  80  


Tyr Asn Pro Ser Phe Gln Gly His Val Thr Ile Ser Ile Asp Lys Ser 
                85                  90                  95      


Thr Asn Thr Ala Tyr Leu His Trp Asn Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Tyr Tyr Val Ser Leu Val Asp Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Arg Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Met Ala Gln 
145                 150                 155                 160 


Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser 
                165                 170                 175     


Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn 
            180                 185                 190         


Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met 
        195                 200                 205             


Ile Tyr Asp Val Asn Asn Arg Pro Ser Glu Val Ser Asn Arg Phe Ser 
    210                 215                 220                 


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
225                 230                 235                 240 


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Gly Ser 
                245                 250                 255     


Arg Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  433
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ET1402L1 scFv

<400>  433

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Glu Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Gly 
                85                  90                  95      


Ser Arg Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Thr 
    130                 135                 140                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asn Tyr Trp Ile Thr 
145                 150                 155                 160 


Trp Val Arg Gln Met Ser Gly Gly Gly Leu Glu Trp Met Gly Arg Ile 
                165                 170                 175     


Asp Pro Gly Asp Ser Tyr Thr Thr Tyr Asn Pro Ser Phe Gln Gly His 
            180                 185                 190         


Val Thr Ile Ser Ile Asp Lys Ser Thr Asn Thr Ala Tyr Leu His Trp 
        195                 200                 205             


Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Tyr 
    210                 215                 220                 


Tyr Val Ser Leu Val Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  434
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ET1402L-TCE

<400>  434

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Glu Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Gly 
                85                  90                  95      


Ser Arg Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Thr 
    130                 135                 140                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asn Tyr Trp Ile Thr 
145                 150                 155                 160 


Trp Val Arg Gln Met Ser Gly Gly Gly Leu Glu Trp Met Gly Arg Ile 
                165                 170                 175     


Asp Pro Gly Asp Ser Tyr Thr Thr Tyr Asn Pro Ser Phe Gln Gly His 
            180                 185                 190         


Val Thr Ile Ser Ile Asp Lys Ser Thr Asn Thr Ala Tyr Leu His Trp 
        195                 200                 205             


Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Tyr 
    210                 215                 220                 


Tyr Val Ser Leu Val Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Asp Ile Lys Leu Gln Gln Ser Gly Ala 
                245                 250                 255     


Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser 
            260                 265                 270         


Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro 
        275                 280                 285             


Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr 
    290                 295                 300                 


Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp 
305                 310                 315                 320 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
                325                 330                 335     


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys 
            340                 345                 350         


Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val Glu 
        355                 360                 365             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val Asp 
    370                 375                 380                 


Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
385                 390                 395                 400 


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
                405                 410                 415     


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
            420                 425                 430         


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
        435                 440                 445             


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
    450                 455                 460                 


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
465                 470                 475                 480 


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys His His His His His His 
                485                 490                 495     


<210>  435
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ET1402L-TCE-HLE

<400>  435

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Glu Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Gly 
                85                  90                  95      


Ser Arg Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Thr 
    130                 135                 140                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asn Tyr Trp Ile Thr 
145                 150                 155                 160 


Trp Val Arg Gln Met Ser Gly Gly Gly Leu Glu Trp Met Gly Arg Ile 
                165                 170                 175     


Asp Pro Gly Asp Ser Tyr Thr Thr Tyr Asn Pro Ser Phe Gln Gly His 
            180                 185                 190         


Val Thr Ile Ser Ile Asp Lys Ser Thr Asn Thr Ala Tyr Leu His Trp 
        195                 200                 205             


Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Tyr 
    210                 215                 220                 


Tyr Val Ser Leu Val Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
            260                 265                 270         


Ser Gly Phe Thr Phe Asn Lys Tyr Ala Met Asn Trp Val Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Tyr Asn 
    290                 295                 300                 


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile 
305                 310                 315                 320 


Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Asn Leu 
                325                 330                 335     


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His Gly Asn Phe 
            340                 345                 350         


Gly Asn Ser Tyr Ile Ser Tyr Trp Ala Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val 
385                 390                 395                 400 


Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala 
                405                 410                 415     


Val Thr Ser Gly Asn Tyr Pro Asn Trp Val Gln Gln Lys Pro Gly Gln 
            420                 425                 430         


Ala Pro Arg Gly Leu Ile Gly Gly Thr Lys Phe Leu Ala Pro Gly Thr 
        435                 440                 445             


Pro Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr 
    450                 455                 460                 


Leu Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Val Leu 
465                 470                 475                 480 


Trp Tyr Ser Asn Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
                485                 490                 495     


Leu Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
                565                 570                 575     


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                725                 730                 735     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            740                 745                 750         


Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        755                 760                 765             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    770                 775                 780                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
785                 790                 795                 800 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                805                 810                 815     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu 
            820                 825                 830         


Gln Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His 
        835                 840                 845             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    850                 855                 860                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
865                 870                 875                 880 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                885                 890                 895     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            900                 905                 910         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        915                 920                 925             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    930                 935                 940                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
945                 950                 955                 960 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                965                 970                 975     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985 


