                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD70

<130>  1

<150>  CN202110604475.1
<151>  2021-05-31

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  1

Met Pro Glu Glu Gly Arg Pro Cys Pro Trp Val Arg Trp Ser Gly Thr 
1               5                   10                  15      


Ala Phe Gln Arg Gln Trp Pro Trp Leu Leu Leu Val Val Phe Ile Thr 
            20                  25                  30          


Val Phe Cys Cys Trp Phe His Cys Ser Gly Leu Leu Ser Lys Gln Gln 
        35                  40                  45              


Gln Arg Leu Leu Glu His Pro Glu Pro His Thr Ala Glu Leu Gln Leu 
    50                  55                  60                  


Asn Leu Thr Val Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly 
                85                  90                  95      


His Leu Arg Ile His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val 
            100                 105                 110         


Thr Leu Ala Asn Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala 
        115                 120                 125             


Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu 
    130                 135                 140                 


Leu Arg Gly Arg Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu 
145                 150                 155                 160 


Thr Tyr Leu Val His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro 
                165                 170                 175     


Leu Leu Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp 
            180                 185                 190         


Ile Cys Pro 
        195 


<210>  2
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  3
<211>  4385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homology arm

<400>  3
agactgctgg gctagagagg aaagcccagc gtattgtagt aggagtgtta ggttaggact       60

tagcaccaac ctttatatcc aacatggccc cagcccctca ttgaggaatt ctagcaggca      120

ggaagacttg gggggatgag ggggacagga caggaccaat tcacccctga ccacaccagc      180

atccctcccc cagagaaatc taagcaggga ctccacccct gagccacgcc cccaaggcca      240

gtggatgagt gtggatgaat gggcaacact tgccaactct atactgctct agcttccatc      300

ctcaccactg caaataataa taataataat aataataata aacatgatgt aaatcattgg      360

tacatggatt ctttataaag ttcaaagtcc tccagcagtt aatttcctag tgtactgcat      420

agttttatgt caatacaaat agggttggac aaggcatgac tgcatttcct tgattaatgt      480

tcaatgtagg agggcccagc acacaacatt tccatggaga tggtcctaag ccctacaaga      540

atgtaggctg agcaagtcag taagccagag atccccctag gctcctgctt cagtcctgcc      600

ttctctcgat gatgaggaac tataaagagg aacaaatcct tccctctcca aggtcacggt      660

gttcatcaac aataaaacct ctagcatgaa ccacatacat tagatgcctc aaagccccca      720

aaatggagct gaagaaatga gttagttatg agcaccggct gggactctcg ctgactctgg      780

agggctccat ttcagctagg ctgatcgatg agctgcggca atcctcctgt ctctgcttct      840

cagcaggcta ccattacaga caggcactga tgaaccccac tttcaggtat caaactcaga      900

gttcccattc ttgcttgatg gggcctgtac cagtaacttt aatttttttt cagaccttat      960

tttcaatgat gattcttaaa cactttaacc ttccttatag cccaccaccc accagaggta     1020

gtgggaaaga aaggatacag gagaagtgga cctgtttaga aaggttcttt ggagcaactc     1080

ctgcctgtgt tgtcaggaaa gaagttcaca ggttagcagc cgcagcttga tccactcaca     1140

aacacttcac ggacacacca gcagtccagt ttggtagagt caagatagca aacaggaatg     1200

aatccgaagt agtggctcta cctagcacta ggagaagctc tctctcagct gtgcctcttt     1260

cagggaagtt aagaacaatt catcagaccc acaggcgttg tacagctagc tccttaagcc     1320

tagctccgcc tctgtcactg tccatcaagc actttttttt tttttcattt ttcgaaacag     1380

ggtttctctg tgtagccctg gctgtcctgg aactcatttt atagaccagg ctggcctcga     1440

actcagaaat ccgcctgcct ctgcctccca agtgctgggt gtaaaggcat gggccaccac     1500

gactggctca tcaagtcctt tttataccct ccaaacctca catgttctcc aagggtcttg     1560

cctcaacact ccgccaatca gcatgagtcc gaggaagctg caagaaactg cagcacacca     1620

ccagaagact tttggtgctc tttttctctc tatagagtcc ctgtgagacc ccgacttaga     1680

gcgtttctcc ctgggaggta aagcccctga atgttccccc aagcctgttt tccctgatct     1740

ctaaaaatac agccagaaag aagctctttg tcctctacag ccagcaaaaa gcctttttgt     1800

ttctatacct tataaccaga gatacgataa ttgtaatttt accaaggaca cctggcagag     1860

aagagctgta gccaactctc ctcccaactc ctcccaactc ctcccaattc ctcagctagc     1920

tgttaaaagc cccctacggt taccactcag ggtggaactc ccctgccctg cgcagcgaag     1980

aggagttcgt cctcagctag ctgataataa aacctcttgc agtttgcatc aggtgtggtt     2040

ttctcaagtc attggggtgc tggccagctc atcccgggac ttgagcggag gcccagcttc     2100

aggggtctta catcccgaca aaggcagcat gttgttagca aagatccttc atcacgtgtc     2160

ctttcacgtg cttgctttag tagaacatgc cctctgctgt gtctgcttca gctaaacgtt     2220

ccttcaggag tctgccttag tctatcacct gtgtccactt caagaaaaca ctccttcact     2280

tgtctgccct agcaaaacac caccaacaca actgactttc caaagaaccc ctaagtttcc     2340

acttcagggc ctgtatccac tgagccatat ccccagccta cttcatattt tttaaagggt     2400

ttgttttgtt ttaatgtatg tgtggggggg cgatatgtgc acaggtgccc atggaaacca     2460

gagttgccaa atactcctag aactggaatt tcagatcgtt ttaaaccatt tgacatgggt     2520

gctgggaagt gagccctctc tctgggatag acacactcaa cctctgagat gtctctccaa     2580

ccccatgtta atctcactat acctgaattg caggagatta gatccagggg ccactgacca     2640

acatgttctc cccaaaacag aatctgaagg tggtggtggc ctctagctgg gccagctcaa     2700

acccatttca gaggcaacct ctccctggta ccctctcctg tagtaggcat ctcaacttcg     2760

gaaaaacttg agcttgtaga tgtgttccaa catttcatca aacagtctgg atcctgggta     2820

aaatagactt ccgtgaagaa cacacagcac tcttggggtg cccagagaag atccagaaga     2880

gaggacagca gagacaggag agatacaagc cccaggcctg ccaggctggg gcagctgctg     2940

cccagctcgg cacctcctgc ctcaagtgtt ttctcgcctc tgccagttct aagtaaactc     3000

tcagctgctc actctgctac cgtatctcat gtggcaaaga ggctagaaca aagtggaggc     3060

cacctgaaag caccaagcct ggttgtctgc ctgttcattc tttattgtct gacagcttcg     3120

tatatttgca aaaatgaatt gtagtcatga ccaccccctt tcccctctcc agtccactcc     3180

cctccttgtc ctgctgaaca ttttcttcca agcaagttct gctccccacc cctgtaatcg     3240

ccactgcctt acaggctttc gagtctcttt ctgtgtgggc tgcactgaat catgggcagg     3300

aggctggttt tctggggcaa tggcaactta ctggtggcca caacactgaa gaaagtgacc     3360

ttcctttccc agtggccaga actgcccaga aagcctcagg gaggggcaga atctcatggc     3420

ccagccccta tcaaggccaa accattcggg gacatcttgt gccaattttc acagctgagt     3480

taagtgtagg agtgcaatgg ctgtgtccac tttcaggtag gatcattgtc tcagtctccg     3540

ggtgacatgg atggggatgg gggtggggat cagcagtagc taatcaatat gctagctatc     3600

atattgagac caagccaagt gtggtggctc acaccagcaa tctagtagtc ctgcagtcag     3660

aaggatgtga gaggccagcc tgggctacat gacaagtttg acacctgcct gagctacttg     3720

aggagctgaa ggtcaccatg gacaccgtgg caaatactaa gccagcctgg gctctacggt     3780

gagttccaat gtgagctgtt tataatggcc ccccatggaa gagcctacaa tcgtgtccaa     3840

atattttggg aagcacaagg gattcctgga tgcggatgct tcctgatttc ctagcattca     3900

gcccaatact gaacctctaa tagatgctca gtgaatggtt tgtcgaatga atgaatgaat     3960

gaatgggcac cgagcagcag gagcaggggc tgaatgccca atcggaagct taaatattct     4020

gaagcaggga caggcctgct tcagtttgtc tgtgggatgg cagaaggtgc caaaagctcc     4080

aggggatttc cctgccctcc gagaagaggc ccagttcttc ccctgcatcg gacatccccg     4140

aggttctaag ggcaggtcaa ggcaggcaga agcttcaaaa gctcggctga ggaggctaca     4200

gcttcccgct gccttcaggc cgctgcttcc gtgcagggat gccggaggaa ggtcgccctt     4260

gcccctgggt tcgctggagc gggaccgcgt tccagcgcca atggccatgg ctgctgctgg     4320

tggtgtttat tactgtgttt tgctgttggt ttcattgtag cggactactc agtaagcagc     4380

aacag                                                                 4385


<210>  4
<211>  4068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homology arm

<400>  4
tactatggag gaggcctgtg cagaagctat aggcctctag gtgggaagtg agcactctaa       60

gcttgacctt caaagctccc tgtgataggt cacagctagg ccccacctcc aaagggtcca      120

catggaccct agattcaaac ctgaacattc caatcctggt cccaataggc ccatgggcat      180

ctcacagtac aaatgtattt aattcaaatt caacaccctc caccccttaa caccttcaat      240

gtctttcaaa agactgagtt cagaggcagc agaaacagct cagcagttag agcaccagct      300

gctcttgcag aggacctggg tttggttcca gcacctatag ggcagctcac agccagctct      360

aactccagct ccagggatcc cacactccgt tctggcctct gtgggcacag tgcacacatg      420

ttgcacagac agacatgaag gcaaaacacc catgcacaga aaaaatttta aaaacagaga      480

ggcctgtcta acagtctaaa ccaactaatc cttaactcgg gggggggggg ggagggcact      540

atgaaactag aatccatcaa ggttttcccg tggtagaaaa taaatcatcc aactgtcaag      600

tggggaggat ggaataggga ggcagatgag gccgaggcaa ggtgaaaccc cagcattgca      660

agttttgctc cctctactcc aaacctggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg      720

tgtgtgtgtg tgtttaaatg tcaaagggtt aaattgacag acaaaagttc attaaacaga      780

cagctaacct agcagacatc ctacctccct gacagcttct ttttgtgctc cagagaacag      840

aacacagcac ttacagtttg cacgagggat gaagctgggt gttgttcaga gccaggatct      900

gtccaggagc cagaggctta ctcttcagtc tagactggct ggctagtgag ctgccagggt      960

ccctcctgtg tccacctccc cagcatggga cacagacagg catgccatca gacacaaagt     1020

ttacatggct gccggagctc tgaacgcagg tttcccctga ctgtcttgtt cctatccaac     1080

ggtctgtcca attccaatgt gtgaactctg ggaacacgtt catttaggct gtagcaaata     1140

ttcacaggca gaaacggtga gtggactata aggaaactct gttctctgct atgcaaacca     1200

taaaaggatg tgttcttaag taaaataaaa atgacctcag tggaaatata ttgtgacggg     1260

aaaggactga ttttcaaggt ttgagcacgg ggggtattat aaagctgcta gggggaatct     1320

ccaccatcca cataggatga tgtcaacagg tgcagccttg aaacttcccc ttcaatgaca     1380

ctcaactgtg tagtaacttg atttatggta ctaagtgaca actgagagga gacctttaat     1440

cccagcactt gggaggcaga ggcaggcaga tctgaattca aagccagcct gatctacaga     1500

gtgattttca gggctataca gtgaaacctt gtgagagctg gggaagcgat ggctactctt     1560

ccagaggacc tgggtttgag tccccgtgct ttatggactg aaccatgcct ggacctttaa     1620

ggttcatttc ccctcaggat gtaggctcca gctctattct gtttctgaag gtctgtgcgt     1680

ataaagttgg gcatcatggc acacacctgt catcccaaca ttcccaggaa gctgaggcag     1740

gaggtttgca agtttgaggc caatcttagc tacatagtgt gctcttatct ggaaaaacaa     1800

aacaaacagt gggaatggga gggagaggaa gaaagggggt gtaaggggag agagagatag     1860

ggaagatggg ggcgggcatg gcagggaaga gagagagaag gaagaatggc gaaggaaatg     1920

caccacctct ctgttcgact ctattgtttg ttccgggtct catttacaaa acagaatagt     1980

tacacatatg tgcttttgaa actcgggatc tggacacaca cactgcacaa tggtcacttc     2040

tattcaacaa gttgaggtct cccgtctcct cagttgaccg tttctcctgc ctgcatgttt     2100

ctctttctgt ggaaatgcta tcaacagtcg atattattac cattgttact gctgaaagtt     2160

cctacagtct cggtcagggc ctccaactga ctcagataca caaccacaac ttctgagtaa     2220

ggtctcacac atttcacagg ggtctaggga gttcagcctt cttatttccc acgtctaagt     2280

aacaatatgc agtagcatcg ttcagggctg aataacactt cattgggtct ggatacccca     2340

ttagttgatt tggctagagc tgaaaataga ggatttcatt atgacatgtt cctacatggg     2400

gctcacattc acccccacaa tattctcttg tccccccttc ctcctacccc cttccccttt     2460

cctctaggcc tcatcaaatt gccccttctt gtatatttct ctctccaaat gcctaatatt     2520

agagaaaagg atggctttgt ctgagtctgt ctatgtctgt cttgttttaa taaaatggcc     2580

tctgtttcta tccataatag aaacatgatt taattccttt ttaaaaggtt ttaaagaatg     2640

tgatttattt attattgatg tgtatgtgat tctcacagtg catgtgcagg tccagggata     2700

gaacctagag tctgccttta cccactggat cagctcaatg cccccccccc accttttctt     2760

taacaggttt tgcacagtcc agtctggcct cacttcactc ttttttacag ttcaataaga     2820

cagcttcatt ttgtgcaatg tgtatctaga ccaaattttc tttttttgaa gacttattta     2880

tgtgtgaaag cccatagaag ccagaaatgg atatagtaac ctctggggag ggagttacag     2940

atggttgtga gtgccagtga gtgcagaatc gaattcagtc ctctgcaaga gctgcccagt     3000

gcgctaacca ctgggccact gctccagcct ctcagccttt tttaagagtc atcctcacag     3060

atatgaggtt tgttgggact ctggttagca ctttctgcca ttgctgcagt tggactcctt     3120

ttgcatactc tctgcccatt tctagtgctt acgaaacaga ttgaacttca ccaagaaagg     3180

aattttgctt ctactgaaaa gacaagccag ggcagcctct ctggggggtc ccattcttca     3240

gagcccaaaa ttaggacggt ggtgtgacct cagcatggac ccaaagaatg ttcaactgac     3300

tcaggacaga cacctgctca tggtactcac tgctgctccc ttcgcagtag ccaagaagtg     3360

tgccagcctg tgtgcctaac agcagattcg tgatgaggaa aacgtgacag cctggtggga     3420

atttctctat ttttgcaggc aatggagaca ggtaatgatg taagctgttg ctaggtccat     3480

gagaagagac tagtcacaat tctattccat tgatatatgt gtctatgcat atatccacgc     3540

ctcagtgttt attttgtctt tgagatagat gagagacaca cagagaatga agtatctatg     3600

gatggataaa tgaatgatag acagacagac aaacagatag atacctagat acatacatag     3660

acacagatat atagatatat agatagatct tagatagata catagatcaa aagacaggtg     3720

atagatgatg atagatatat agacagataa taatacatat agatgcatac atacacatat     3780

atagagagat acatacatac atacatacat atacatacat atgtgcatag ttacatacat     3840

ggaaacatag ataataattg tcctataaga cagcctgggc tcacctccac catcctgttt     3900

tcataagtga acttccagct ttcaactgtt ttctgatgga tttatcttga ttttgtttgt     3960

ttatttgacc aattggttgg ttgagcaact tttgagacaa ggtctcatgt agtctaagcc     4020

tcaaactatc tgtaaagctg aatacatcct tcaactcctg cttcttcc                  4068


<210>  5
<211>  4842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence from 6586020 to 6590861 of the NCBI accession
       number NC_000019.10

<400>  5
ctgccgctcg agtcacttgg ggtgagttga gatggaaaag ttgggaagaa aacatagaga       60

ggcgcgtgac cgaaaagaca gaatgagatg ggtacaaaga ggccagagag gaagatctgg      120

tagggcagag acagagacca gaacagggag gcgaggcggg gaccaggctg cccggtgtag      180

gggctacgag acaggcagcc ctgccaggag gtacagggag atcccgggat gggaaaggta      240

ggcacacatg gaaatggaag atgactcggc tctggtgttc ccccggcagg ctgactcaga      300

ggctgctggg ggcttcacaa ggctgggcgt gggggcttcc tggggcctcc taggacggga      360

tggccccagc cactcgctcc gggtggggga ggggtccctt tggggaccgc gccgggcgcc      420

tttgcagcgt agagagtccg ctgcgcgcgg tgctctcgcg cccagtgaca tccaggaaaa      480

cgattcggga aacgaagaag ttcttttgaa ggtctcgact tcacgttccc cgctggttca      540

gacctgcttc ctctttaaga agtcttaaga gtaaaaaaaa ataaaatgaa ataaaatcac      600

cagtgcgcgc cgtgggatga gaggtggaaa ggaggatgga cagagaaaag agagctcctg      660

gcacagggga cacatagaac ctctctgctt acgtccgtgc cctgttttct ggtcttttct      720

tccagtggga cgtagctgag ctgcagctga atcacacagg taacacgggg gacgtggagg      780

gacggggaga agaagaggca cagagagaga aggaaggaga ggtagaaaga caagtgggga      840

gagacagaga gaaagagaca cagacagaga cggagggaga gagggaggga gagataggga      900

gggaaacgga gagggggaga cagagagaag acagagaggg agggagaggc ccagagaaag      960

ggagggagag acagaaaaaa gaacagagag agggacagag gggacagacg ggacaggaga     1020

agaaggggaa agaaagaaac agggagagac gcagggagag tggaagaggg agggagggag     1080

acaggcgggg gagacagaac gagagagagg gagagagacg gagaaagaga aaaaagacag     1140

atagaggaag agagaataaa aacgagagag gcgacctggc gtggttgctg gagcctgtaa     1200

tcccagcgct ttcggagggc gcggcgggtg gatcacttga gcccaggagt ttgagaccag     1260

cctggccaac atggtgaaac cccgtctcta ctaaaattac aaaaattagc cgggtgtggt     1320

ggcaggcacc tgtaatccca gctactcagg aggccgaggc aggagaatcg cctgaacctg     1380

ggaggcagaa gttgcagtga gccaagataa tggcactgct ctccagcctg ggtgacagag     1440

ggagattctg tcaaataaat aaataaaaag aagaaaggaa aagaaaaaga aagaaaggaa     1500

ggaaggaaaa gaaagagaag aaggaaggaa ggagagaggg agggaggtga gagagagaga     1560

aaggaaaaag aaagaagaaa gagaaaaaaa gaaataagag aaagaaaaga aagaaagcca     1620

gagagaggaa aagagaagga gaataacaga gaggaagaga cagagacaga gagggggaag     1680

aagaaaaaca gggcggggga gaaagagatc attcccaaga gaaaaaggaa aagggagaga     1740

acgagagaga gagagaggag agagagagcg agcaggtttg tgtttctggg catccactac     1800

ctttctctcc ctttccctct cagtccttca cattcgatct cctcccttgg aagaatcaaa     1860

ggggttttgt tagtaaacga aaacgctcac aggaaaggct acccttcctc cattcatgct     1920

acaagcacta attatacatc tgcagtgggc aggcactgtt ccggtactgc agtcgcgcac     1980

aaaacagaca gaaatccctg cctggtgagc ttcccttcta ctatcactcc taccgaggag     2040

gagatgacca aaaaaataaa aacgaacatg tgaaaaacag agcaatgcca cgtagagtaa     2100

aacaggccaa gagcaggttt tagagaaaaa atcaggcaag gaggtgggtg gggaatccgg     2160

gcatgccagg gttggggatt ttcatttaaa gtggagtcgc ggcggtcggg tgggggggtg     2220

gtatctgagt gggtggcatt ggcaagaagc cttgagggag aagaaatgaa cagttctgct     2280

ctaggtggaa gtctctacct cctcccagcc tctctcgaac gcttcttcct cttctgtttt     2340

tccacggttc atccccagag actaaaatta ctgcacgctt gcgtgttttg ttccttccat     2400

tttgtaatgg aagggacctt tgttgctctc tcttctcctt gggtctctga cccctgatat     2460

atcttccccc cctccccggc ctttgccata tttttcctgt aatttggtct tgaggcccct     2520

ttctggagag tggctgtcca gccccacatc gatggggcac caggggtggt ggccacaggt     2580

gttgacagtg tctttcacag gacagctctt tcttctggtg gatgatatca tgcctaagtg     2640

tgtgacaggg gaccaggtgt cactcttaca ggaaatttgc aaagcctggt aaacaccctt     2700

ggggctcctg tttgaccccg ttcagttcct tcctaacaag atagccagtc tccaggagag     2760

ccttgagtga ggaggagagt gaggctcagg tgtgtcagtc agataagttg cggagacagg     2820

agacgctgag atgaaacacg tgaaatatag ccgaggacct tggctcccgg ctgtgatccc     2880

agcgctttgg gaggctgagg tgggaggatc gcttgagccc aggagttcta gactatgttt     2940

cttgggaaac atagcaagac caccatctct agaacaaaat tttgaaaatt agctggtcat     3000

ggtggcgcat gccacctccc agtgactcgg gaggctgagg tgggagatag cttgagcccc     3060

agaggctgag gctgcagtga gctatgattg caccactgca ctccagcctg ggtgacagga     3120

ccagaccctg tctctaaaga aaataaagat cctagagaga agagggccaa cgggaaggta     3180

ggggagctct ctgagacaca cactcaacca gcgggtggaa agcaagaaaa aaaaagggtc     3240

ctgggagcca aagcttttat tggcgttcag ggtgtgaccc gagcaggcgt cccttgggga     3300

attctctcgt gcactctctt gcgcgctgtc tcgtgcgcac gctgtctctc tcgtgctgtc     3360

tgtctcactc tctcaggcac tctctcgctc actcccgtgc actctcgagc tctgtagctc     3420

tcatcctctc tcacacacac actctcccat gcactctctc gagctcactc tcacactctg     3480

tctcgtgcac tctctctcaa gctctctcgt cctctctcac acacacactc tctctcttgc     3540

tctctctctc atgctgtctc tcgtactctc tcctgctctc tcgtgctctc tctcactctc     3600

tcgtgcactc tccctcaagc tctctcgtcc tctctctcac actctctcgc tgtctcatgc     3660

tctctctccc tcatgatctc tctctctctc atgctgtctc ttgcactctc tcctgctctc     3720

tcgtgctctc tcgcactctc tcgtgcactc tccctcaagc tctctcgtcc tctcacacac     3780

tctctcgctc tctcatgctc tctctctcat gctctctgtc gcactctctc gtgcactctc     3840

gtcctctctc acacatacac tctctctctt gctctctctc tgcattctct ctctatatat     3900

ctctccctcc ccctctatct ttacccttgt ctgtttctgt tttttttttt tttttttttg     3960

tctctctctc tcctggtgtc tctctctccc tgtctctacc cctttcccct tacccctctc     4020

tccttccctt tagatctcta accttctatc cccctccctt ttttttgaga cagggtttct     4080

gtgaccaagg ctggagtgca gtggtgtgat catagctcac tgcagtctca gcctcccagg     4140

ctcaagcgat cctccagcct cagcctccca agagtagcca ggaccagagg cgtgcaccac     4200

cacacctggc tgacttttta ttttttgtag agatggggtc tcgccctgtt gtccaggctg     4260

gtcttgaact gctgacctca ggtgatccac ccgccttggc ctcctaaact gttaggattt     4320

caggcatgag ccaccacgtc caacctattc cttgatctct aactctcgat ctctatatct     4380

gactttctct atgaccccct gtgcctcagt ttccctaaac ctccatcctc tcatccctct     4440

aaccctgtgc ccccaggacc tcagcaggac cccaggctat actggcaggg gggcccagca     4500

ctgggccgct ccttcctgca tggaccagag ctggacaagg ggcagctacg tatccatcgt     4560

gatggcatct acatggtaca catccaggtg acgctggcca tctgctcctc cacgacggcc     4620

tccaggcacc accccaccac cctggccgtg ggaatctgct ctcccgcctc ccgtagcatc     4680

agcctgctgc gtctcagctt ccaccaaggt tgtaccattg cctcccagcg cctgacgccc     4740

ctggcccgag gggacacact ctgcaccaac ctcactggga cacttttgcc ttcccgaaac     4800

actgatgaga ccttctttgg agtgcagtgg gtgcgcccct ga                        4842


<210>  6
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  junction sequence upstream of the human CD70 sequence in the A 
       fragment

<400>  6
ttggtttcat tgtagcggac tactcagtaa gcagcaacag ctgccgctcg agtcacttgg       60

ggtgagttga gatggaaaag                                                   80


<210>  7
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  junction sequence downstream of human CD70 sequence in the A 
       fragment

<400>  7
tgatgagacc ttctttggag tgcagtgggt gcgcccctga ccacaactcc aggatgactt       60

gtgaatattt tttttctttt                                                   80


<210>  8
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 5' end of the Neo cassette and the mouse 
       gene

<400>  8
taaaatttta attctgttct tagtaacact cctcacgcag cacccagtgg atatcgaatt       60

ccgaagttcc tattctctag                                                   80


<210>  9
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 3' end of the Neo cassette and the mouse 
       gene

<400>  9
gaagttccta ttctctagaa agtataggaa cttcatcagt caggtacata atggtggatc       60

cactagttct agagcggccg ctactatgga ggaggcctgt gcagaagcta taggcctcta      120

g                                                                      121


<210>  10
<211>  842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the modified humanized mouse CD70

<400>  10
gaaggtgcca aaagctccag gggatttccc tgccctccga gaagaggccc agttcttccc       60

ctgcatcgga catccccgag gttctaaggg caggtcaagg caggcagaag cttcaaaagc      120

tcggctgagg aggctacagc ttcccgctgc cttcaggccg ctgcttccgt gcagggatgc      180

cggaggaagg tcgcccttgc ccctgggttc gctggagcgg gaccgcgttc cagcgccaat      240

ggccatggct gctgctggtg gtgtttatta ctgtgttttg ctgttggttt cattgtagcg      300

gactactcag taagcagcaa cagctgccgc tcgagtcact tgggtgggac gtagctgagc      360

tgcagctgaa tcacacagga cctcagcagg accccaggct atactggcag gggggcccag      420

cactgggccg ctccttcctg catggaccag agctggacaa ggggcagcta cgtatccatc      480

gtgatggcat ctacatggta cacatccagg tgacgctggc catctgctcc tccacgacgg      540

cctccaggca ccaccccacc accctggccg tgggaatctg ctctcccgcc tcccgtagca      600

tcagcctgct gcgtctcagc ttccaccaag gttgtaccat tgcctcccag cgcctgacgc      660

ccctggcccg aggggacaca ctctgcacca acctcactgg gacacttttg ccttcccgaa      720

acactgatga gaccttcttt ggagtgcagt gggtgcgccc ctgaccacaa ctccaggatg      780

acttgtgaat attttttttc ttttcaagtt ctacgtattt ataaatgtat atagtacaca      840

ta                                                                     842


<210>  11
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  expressed protein sequence of the modified humanized mouse CD70

<400>  11

Met Pro Glu Glu Gly Arg Pro Cys Pro Trp Val Arg Trp Ser Gly Thr 
1               5                   10                  15      


Ala Phe Gln Arg Gln Trp Pro Trp Leu Leu Leu Val Val Phe Ile Thr 
            20                  25                  30          


Val Phe Cys Cys Trp Phe His Cys Ser Gly Leu Leu Ser Lys Gln Gln 
        35                  40                  45              


Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu 
    50                  55                  60                  


Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly 
                85                  90                  95      


Gln Leu Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val 
            100                 105                 110         


Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr 
        115                 120                 125             


Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu 
    130                 135                 140                 


Leu Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu 
145                 150                 155                 160 


Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr 
                165                 170                 175     


Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp 
            180                 185                 190         


Val Arg Pro 
        195 


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
cactgccacg gaattcttga ggtga                                             25


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
tcattctgtc ttttcggtca cgcg                                              24


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
gctcgactag agcttgcgga                                                   20


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
acagtctgga cctccgaggc a                                                 21


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  16
agaagcaact tgcagaaggg acagg                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  17
tttagaggcc ctcggagatt ggtct                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  18
tctcctctct ctttgttggc tctgg                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  19
aaggccttct agcacaggat ctcca                                             25


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  20
ggatcggcca ttgaacaaga t                                                 21


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  21
cagaagaact cgtcaagaag gc                                                22


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gtctgtggga tggcagaagg tgcca                                             25


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
ctcatgccac ccttcccact acttc                                             25


<210>  24
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
ccacaggtgt tgacagtgtc tttcac                                            26


<210>  25
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
tctagagatg gtggtcttgc tatgttt                                           27


<210>  26
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
tacaacccag ctccctctca gcac                                              24


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
gggaccagga ttggaatgtt caggt                                             25


<210>  28
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
gacaagcgtt agtaggcaca tatac                                             25


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
gctccaattt cccacaacat tagt                                              24


<210>  30
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
tgctggtggt gtttattact gtg                                               23


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
cagggtgagg ttggtacaga g                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
tagcggacta ctcagtaagc a                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
cagtgtttcg ggaaggcaaa                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
accacagtcc atgccatcac                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
tacagcaaca gggtggtgga                                                   20


<210>  36
<211>  195
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Met Pro Glu Glu Gly Arg Pro Tyr Pro Trp Val Arg Trp Ser Trp Ser 
1               5                   10                  15      


Ala Phe Gln Arg Leu Leu Pro Trp Leu Leu Met Val Ile Ile Ala Ile 
            20                  25                  30          


Cys Trp Trp Leu Leu Cys Gly Gly His Leu Ser Lys Pro Gln His Val 
        35                  40                  45              


Leu Leu Glu Pro Pro Glu Leu His Val Ala Glu Leu Gln Leu Asn Leu 
    50                  55                  60                  


Thr Asp Pro Gln Lys Asp Leu Thr Leu Arg Trp Gly Ala Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Thr His Gly Pro Gly Leu Glu Lys Gly Asn Leu 
                85                  90                  95      


Arg Ile His Gln Asp Gly Ile Tyr Arg Leu His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Asn Cys Ser Ser Ser Gly Ser Ala Leu Gln His Arg Ala Ser Leu 
        115                 120                 125             


Val Val Gly Ile Cys Ser Pro Ala Val His Ile Ile Ser Leu Leu Arg 
    130                 135                 140                 


Arg Arg Phe Gly Gln Asp Cys Thr Val Ser Leu Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Val Leu Cys Ser Asn Leu Thr Gln Pro Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Arg Val Tyr 
            180                 185                 190         


Pro Trp Pro 
        195 


