                         SEQUENCE LISTING

<110>  Huahui Health Ltd.
 
<120>  ANTI-CD98 ANTIBODIES AND USES THEREOF

<130>  CR12877HHH33WO

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Small guided RNA targeting CD98

<400>  1
ccgcgctgcc gtgagctgcc tgt                                               23


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y1-F primer

<400>  2
gggtcaagtt caccggctta                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Y1-R primer

<400>  3
ctcaggtaat cgagacgccc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT1-F primer

<400>  4
gtgaagatca aggtggcgga                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT1-R primer

<400>  5
aaaaagcagc agaatgcccg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS2-F primer

<400>  6
gggtcaagtt caccggctta                                                   20


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MS2-R primer

<400>  7
ctgggccaga atgccaaac                                                    19


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-1 primer

<400>  8
gtgtaagccc cgaggagaat                                                   20


<210>  9
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 
1               5                   10                  15      


Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 
            20                  25                  30          


Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 
        35                  40                  45              


Glu Asp Glu Ala Glu Ala Ala Ala Ala Ala Lys Phe Thr Gly Leu Ser 
    50                  55                  60                  


Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 
65                  70                  75                  80  


Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 
                85                  90                  95      


Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu 
            100                 105                 110         


Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp 
        115                 120                 125             


Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys 
    130                 135                 140                 


Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu 
145                 150                 155                 160 


Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu 
                165                 170                 175     


Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu 
            180                 185                 190         


Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr 
        195                 200                 205             


Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr 
    210                 215                 220                 


Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly 
225                 230                 235                 240 


Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser 
                245                 250                 255     


Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp 
            260                 265                 270         


Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu 
        275                 280                 285             


Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln 
305                 310                 315                 320 


Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln 
                325                 330                 335     


Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr 
            340                 345                 350         


Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly 
        355                 360                 365             


Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu 
    370                 375                 380                 


Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly 
385                 390                 395                 400 


Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly 
                405                 410                 415     


Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu 
            420                 425                 430         


Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly 
        435                 440                 445             


Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val 
    450                 455                 460                 


Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser 
465                 470                 475                 480 


Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu 
                485                 490                 495     


Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg 
            500                 505                 510         


Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala 
        515                 520                 525             


Ala 
    


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 HCDR1

<400>  10

Ser Tyr Tyr Met His 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 HCDR2

<400>  11

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 HCDR3

<400>  12

Gly Tyr Tyr Asp Ile Leu Thr Gly Ser Arg Pro Ile Phe Phe Asp Ile 
1               5                   10                  15      


<210>  13
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 VH amino acid seq

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Tyr Asp Ile Leu Thr Gly Ser Arg Pro Ile Phe Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S1-F4 VH DNA seq

<400>  14
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagggggtat      300

tacgatattt tgactggttc ccgacctatt ttttttgata tctggggcca agggacaatg      360

gtcaccgtct cttca                                                       375


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 LCDR1

<400>  15

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 LCDR2

<400>  16

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 LCDR3

<400>  17

Gln Gln Tyr Tyr Asn Thr Pro Ile Thr 
1               5                   


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S1-F4 VL amino acid seq

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  19
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S1-F4 VL DNA seq

<400>  19
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagttgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg gaacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact      300

ccgatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 HCDR1

<400>  20

Ser Tyr Gln Met His 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 HCDR2

<400>  21

Ile Ile Asn Asp Lys His Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 HCDR3

<400>  22

Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe Asp Ile 
1               5                   10                  15      


<210>  23
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 VH amino acid seq

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Asp Lys His Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  24
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H15L54 VH DNA seq

<400>  24
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctaccaga tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacgaca agcacggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagggggtat      300

gaggatagca acactcacca gcacccgatt ttttttgata tctggggcca agggacaatg      360

gtcaccgtct cttca                                                       375


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 LCDR1

<400>  25

Lys Ser Ser Gln Ser Val Leu Tyr Arg His Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 LCDR2

<400>  26

Trp Ala Ser Thr Ser Glu Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 LCDR3

<400>  27

Gln Gln Tyr Tyr Asn Thr Pro Ile Thr 
1               5                   


<210>  28
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L54 VL amino acid seq

<400>  28

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg 
            20                  25                  30          


His Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Ser Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  29
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H15L54 VL DNA seq

<400>  29
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtgctg tacaggcaca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagttgctca tttactgggc atctaccagc      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg gaacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact      300

ccgatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 HCDR1

<400>  30

Ser Tyr Gln Met His 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 HCDR2

<400>  31

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 HCDR3

<400>  32

Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe Asp Ile 
1               5                   10                  15      


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 VH amino acid seq

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8332 VH DNA seq

<400>  34
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctaccaga tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagggggtat      300

gaggatagca acactcacca gcacccgatt ttttttgata tctggggcca agggacaatg      360

gtcaccgtct cttca                                                       375


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 LCDR1

<400>  35

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 LCDR2

<400>  36

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 LCDR3

<400>  37

Gln Gln Tyr Tyr Asn Thr Pro Ile Thr 
1               5                   


<210>  38
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8332 VL amino acid seq

<400>  38

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  39
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8332 VL DNA seq

<400>  39
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagttgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg gaacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact      300

ccgatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 HCDR1

<400>  40

Ser Tyr Gln Met His 
1               5   


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 HCDR2

<400>  41

Ile Ile Asn Asp Lys His Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 HCDR3

<400>  42

Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe Asp Ile 
1               5                   10                  15      


<210>  43
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 VH amino acid seq

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Asp Lys His Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H15L1 VH DNA seq

<400>  44
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctaccaga tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacgaca agcacggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagggggtat      300

gaggatagca acactcacca gcacccgatt ttttttgata tctggggcca agggacaatg      360

gtcaccgtct cttca                                                       375


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 LCDR1

<400>  45

Lys Ser Ser Gln Ser Val Leu Tyr Arg His Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 LCDR2

<400>  46

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 LCDR3

<400>  47

Gln Gln Tyr Tyr Asn Thr Pro Ile Thr 
1               5                   


<210>  48
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L1 VL amino acid seq

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg 
            20                  25                  30          


His Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  49
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H15L1 VL DNA seq

<400>  49
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtgctg tacaggcaca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagttgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg gaacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact      300

ccgatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 HCDR1

<400>  50

Ser Tyr Gln Met His 
1               5   


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 HCDR2

<400>  51

Ile Ile Asn Asp Lys His Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 HCDR3

<400>  52

Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe Asp Ile 
1               5                   10                  15      


<210>  53
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 VH amino acid seq

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Asp Lys His Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Glu Asp Ser Asn Thr His Gln His Pro Ile Phe Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  54
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H15L35 VH DNA seq

<400>  54
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctaccaga tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacgaca agcacggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagggggtat      300

gaggatagca acactcacca gcacccgatt ttttttgata tctggggcca agggacaatg      360

gtcaccgtct cttca                                                       375


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 LCDR1

<400>  55

Lys Ser Ser Gln Ser Val Leu Tyr Arg His Asn Asn Asn Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 LCDR2

<400>  56

Trp Ala Ser Thr Ser Glu Ser 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 LCDR3

<400>  57

Gln Gln Tyr Tyr Asn Thr Pro Ile Thr 
1               5                   


<210>  58
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H15L35 VL amino acid seq

<400>  58

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Arg 
            20                  25                  30          


His Asn Asn Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Ser Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  59
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H15L35 VL DNA seq

<400>  59
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtgctg tacaggcaca acaataacaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagttgctca tttactgggc atctaccagc      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg gaacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact      300

ccgatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 HCDR1

<400>  60

Ser Tyr Tyr Met His 
1               5   


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 HCDR2

<400>  61

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 HCDR3

<400>  62

Gly Tyr Cys Ser Gly Gly Arg Cys Tyr Ser Asp Phe Gln His 
1               5                   10                  


<210>  63
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 VH amino acid seq

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Tyr Cys Ser Gly Gly Arg Cys Tyr Ser Asp Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  64
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HN2-G9 VH DNA seq

<400>  64
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt atttctgtgc gagaggatat      300

tgtagtggcg gtaggtgcta ctctgacttc cagcactggg gccagggcac cctggtcacc      360

gtctcctca                                                              369


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 LCDR1

<400>  65

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 LCDR2

<400>  66

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 LCDR3

<400>  67

Gln Gln Tyr Tyr Asn Thr Pro Ile Thr 
1               5                   


<210>  68
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HN2-G9 VL amino acid seq

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  69
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HN2-G9 VL DNA seq

<400>  69
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct      120

tggtaccagc agaaaccagg acagcctcct aagttgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg gaacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttataatact      300

ccgatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 HCDR1

<400>  70

Asn Asn Tyr Met Ser 
1               5   


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 HCDR2

<400>  71

Val Ile Tyr Ser Gly Gly Lys Thr Tyr Tyr Ala Asp Ser Ala Lys Gly 
1               5                   10                  15      


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 HCDR3

<400>  72

Val Ser Gly Leu Gly Trp Phe Asp Pro 
1               5                   


<210>  73
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 VH amino acid seq

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Lys Thr Tyr Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Ser Gly Leu Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  74
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BC8 VH DNA seq

<400>  74
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccgtcagt aataattaca tgagctgggt ccgccaggct      120

ccagggaagg gactggagtg ggtctcagtt atttatagtg gtgggaaaac atactacgcg      180

gactccgcga agggcagatt caccatctcc agagacaatt ccaagaacac ggtgtttctt      240

caaatgaaca gcctgagagt cgaggacacg gctgtgtatt actgtgcgag agtttcaggc      300

cttggctggt tcgacccctg gggccaggga accctggtca ccgtctcctc a               351


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 LCDR

<400>  75

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 LCDR2

<400>  76

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 LCDR3

<400>  77

Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val 
1               5                   10      


<210>  78
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC8 VL amino acid seq

<400>  78

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  79
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BC8 VL DNA seq

<400>  79
cagtctgtgt tgacgcagcc gccctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggttgggtg      300

ttcggcggag ggaccaagct gaccgtccta                                       330


