                         SEQUENCE LISTING

<110>  McMaster University
       Ottawa Hospital Research Institute
 
<120>  EXPRESSION OF BACTERIAL DINUCLEOTIDE CYCLASES

<130>  H8313117PCT

<140>  PCT/CA2022/050878
<141>  2022-06-01

<150>  US63/195,419
<151>  2021-06-01

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  1005
<212>  DNA
<213>  Vibrio cholerae

<400>  1
atgaacgata aggtcctgga gagcgtgatt gagattaccg aacagaaaaa tagtctggca       60

ctgagctaca gcatcctggc aacactgtct gagctgctgc ctctgagcac agccacactg      120

ttccaccacc tgggcaggag caccctgatg gtggcaagac tgatcatcac aaagaatgca      180

gcaggcaaga aggagtatca gtggcagtat gatcaggtgt gcgcagataa tggataccag      240

cactcccagt ctgagatggc cttttcccag caggccaatg gccagtatca gtgcttctgt      300

cccatcccta tcgaggagca cttttctgcc gagctgtgcc tgatcctgaa caaggaccca      360

gagccctaca ggatgctgat caacggcttc gccaagatct accgcaatta taccgtgatc      420

ctgcacgagt ctgagagaga caagctgaca ggcctgctga atagaagaac actggaggat      480

cggctgagac acacctttgc catcaaccca tccacagagg agaatcacaa gctgtggatc      540

gccatgctgg acatcgatca cttcaaggcc atcaatgacc actttggcca catgatcggc      600

gatgagatcc tgctgatgtt cgcccagcag atgcagcact attttggacc tagctcccag      660

ctgttccggt ttggcggcga ggagttcgtg atcatctttt cttctggaaa tgagccacag      720

atcaagcagc agctggatgg cttccggcag cagatcaggc gccacaattt tcctaggatt      780

ggagagctga gcttctccgc cggattttgt tctctgcggc ccggcgatta cctgccaaca      840

atcctggacc acgccgataa ggccctgtac tatgcaaaag agcacggaag gaaccaggtg      900

cactgctatg agcagctgtg cgagaatggc aagatcgcct ccgcccagcg accattctcc      960

gatgatgtgg aactgtttga ctacaaggat gacgatgata aataa                     1005


<210>  2
<211>  334
<212>  PRT
<213>  Vibrio cholerae

<400>  2

Met Asn Asp Lys Val Leu Glu Ser Val Ile Glu Ile Thr Glu Gln Lys 
1               5                   10                  15      


Asn Ser Leu Ala Leu Ser Tyr Ser Ile Leu Ala Thr Leu Ser Glu Leu 
            20                  25                  30          


Leu Pro Leu Ser Thr Ala Thr Leu Phe His His Leu Gly Arg Ser Thr 
        35                  40                  45              


Leu Met Val Ala Arg Leu Ile Ile Thr Lys Asn Ala Ala Gly Lys Lys 
    50                  55                  60                  


Glu Tyr Gln Trp Gln Tyr Asp Gln Val Cys Ala Asp Asn Gly Tyr Gln 
65                  70                  75                  80  


His Ser Gln Ser Glu Met Ala Phe Ser Gln Gln Ala Asn Gly Gln Tyr 
                85                  90                  95      


Gln Cys Phe Cys Pro Ile Pro Ile Glu Glu His Phe Ser Ala Glu Leu 
            100                 105                 110         


Cys Leu Ile Leu Asn Lys Asp Pro Glu Pro Tyr Arg Met Leu Ile Asn 
        115                 120                 125             


Gly Phe Ala Lys Ile Tyr Arg Asn Tyr Thr Val Ile Leu His Glu Ser 
    130                 135                 140                 


Glu Arg Asp Lys Leu Thr Gly Leu Leu Asn Arg Arg Thr Leu Glu Asp 
145                 150                 155                 160 


Arg Leu Arg His Thr Phe Ala Ile Asn Pro Ser Thr Glu Glu Asn His 
                165                 170                 175     


Lys Leu Trp Ile Ala Met Leu Asp Ile Asp His Phe Lys Ala Ile Asn 
            180                 185                 190         


Asp His Phe Gly His Met Ile Gly Asp Glu Ile Leu Leu Met Phe Ala 
        195                 200                 205             


Gln Gln Met Gln His Tyr Phe Gly Pro Ser Ser Gln Leu Phe Arg Phe 
    210                 215                 220                 


Gly Gly Glu Glu Phe Val Ile Ile Phe Ser Ser Gly Asn Glu Pro Gln 
225                 230                 235                 240 


Ile Lys Gln Gln Leu Asp Gly Phe Arg Gln Gln Ile Arg Arg His Asn 
                245                 250                 255     


Phe Pro Arg Ile Gly Glu Leu Ser Phe Ser Ala Gly Phe Cys Ser Leu 
            260                 265                 270         


Arg Pro Gly Asp Tyr Leu Pro Thr Ile Leu Asp His Ala Asp Lys Ala 
        275                 280                 285             


Leu Tyr Tyr Ala Lys Glu His Gly Arg Asn Gln Val His Cys Tyr Glu 
    290                 295                 300                 


Gln Leu Cys Glu Asn Gly Lys Ile Ala Ser Ala Gln Arg Pro Phe Ser 
305                 310                 315                 320 


Asp Asp Val Glu Leu Phe Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 330                 


<210>  3
<211>  1101
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  3
atgcacgctg tgacaagacc taccctgcgg gaggctgtgg cacggctggc acctgggact       60

ggactgagag atggactgga gagaatcctg agaggaagaa caggcgccct gatcgtgctg      120

ggccacgacg agaacgtgga ggccatctgc gacggcggct tcagcctgga tgtgcggtac      180

gccgccacac ggctgagaga gctgtgcaag atggatggag cagtggtgct gtccacagat      240

ggcagccgga tcgtgagagc aaatgtgcag ctggtgccag acccctctat tccaacagat      300

gagtctggaa ccaggcaccg ctccgccgag agagccgcca tccagacagg ctaccctgtg      360

atcagcgtgt cccactctat gaacatcgtg accgtgtatg tgaggggcga gagacacgtg      420

ctgaccgaca gcgccaccat cctgtctagg gcaaaccagg caattgccac actggagagg      480

tataaaacaa gactggatga ggtgtccaga cagctgtcta gagcagagat cgaggacttt      540

gtgacactgc gggatgtgat gacagtggtg cagagactgg agctggtgcg gagaattggc      600

ctggtcatcg actacgatgt ggtggagctg ggaacagatg gccggcagct gagactgcag      660

ctggacgagc tgctgggcgg caacgataca gcaagggagc tgatcgtgcg cgattatcac      720

gcaaacccag aacccccttc taccgggcag atcaatgcca ccctggatga gctggatgca      780

ctgtctgatg gcgatctgct ggacttcaca gccctggcaa aggtgtttgg atacccaacc      840

acaaccgaag cacaggatag caccctgtcc cctaggggct atcgcgccat ggccggcatc      900

ccaaggctgc agttcgccca cgccgatctg ctggtgcgcg cctttggcac cctgcagggc      960

ctgctggccg cctctgccgg cgacctgcag agcgtggatg gcatcggcgc catgtgggcc     1020

cggcacgtga gagagggcct gtctcagctg gcagagtcca ccatttccga ccaggattac     1080

aaagatgatg atgataagta a                                               1101


<210>  4
<211>  366
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  4

Met His Ala Val Thr Arg Pro Thr Leu Arg Glu Ala Val Ala Arg Leu 
1               5                   10                  15      


Ala Pro Gly Thr Gly Leu Arg Asp Gly Leu Glu Arg Ile Leu Arg Gly 
            20                  25                  30          


Arg Thr Gly Ala Leu Ile Val Leu Gly His Asp Glu Asn Val Glu Ala 
        35                  40                  45              


Ile Cys Asp Gly Gly Phe Ser Leu Asp Val Arg Tyr Ala Ala Thr Arg 
    50                  55                  60                  


Leu Arg Glu Leu Cys Lys Met Asp Gly Ala Val Val Leu Ser Thr Asp 
65                  70                  75                  80  


Gly Ser Arg Ile Val Arg Ala Asn Val Gln Leu Val Pro Asp Pro Ser 
                85                  90                  95      


Ile Pro Thr Asp Glu Ser Gly Thr Arg His Arg Ser Ala Glu Arg Ala 
            100                 105                 110         


Ala Ile Gln Thr Gly Tyr Pro Val Ile Ser Val Ser His Ser Met Asn 
        115                 120                 125             


Ile Val Thr Val Tyr Val Arg Gly Glu Arg His Val Leu Thr Asp Ser 
    130                 135                 140                 


Ala Thr Ile Leu Ser Arg Ala Asn Gln Ala Ile Ala Thr Leu Glu Arg 
145                 150                 155                 160 


Tyr Lys Thr Arg Leu Asp Glu Val Ser Arg Gln Leu Ser Arg Ala Glu 
                165                 170                 175     


Ile Glu Asp Phe Val Thr Leu Arg Asp Val Met Thr Val Val Gln Arg 
            180                 185                 190         


Leu Glu Leu Val Arg Arg Ile Gly Leu Val Ile Asp Tyr Asp Val Val 
        195                 200                 205             


Glu Leu Gly Thr Asp Gly Arg Gln Leu Arg Leu Gln Leu Asp Glu Leu 
    210                 215                 220                 


Leu Gly Gly Asn Asp Thr Ala Arg Glu Leu Ile Val Arg Asp Tyr His 
225                 230                 235                 240 


Ala Asn Pro Glu Pro Pro Ser Thr Gly Gln Ile Asn Ala Thr Leu Asp 
                245                 250                 255     


Glu Leu Asp Ala Leu Ser Asp Gly Asp Leu Leu Asp Phe Thr Ala Leu 
            260                 265                 270         


Ala Lys Val Phe Gly Tyr Pro Thr Thr Thr Glu Ala Gln Asp Ser Thr 
        275                 280                 285             


Leu Ser Pro Arg Gly Tyr Arg Ala Met Ala Gly Ile Pro Arg Leu Gln 
    290                 295                 300                 


Phe Ala His Ala Asp Leu Leu Val Arg Ala Phe Gly Thr Leu Gln Gly 
305                 310                 315                 320 


Leu Leu Ala Ala Ser Ala Gly Asp Leu Gln Ser Val Asp Gly Ile Gly 
                325                 330                 335     


Ala Met Trp Ala Arg His Val Arg Glu Gly Leu Ser Gln Leu Ala Glu 
            340                 345                 350         


Ser Thr Ile Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
        355                 360                 365     


<210>  5
<211>  699
<212>  DNA
<213>  Listeria Monocytogenes

<400>  5
atgaagggca tctttatcat catcgctgtg aagctgctgt ccggattctt tggcctgcag       60

accgtggagt ggatcacaga ccagatgctg acctggggct tcctggccat catcatcatc      120

tttcagccag agctgaggcg cgctctggag acactgggaa ggggcaacat cttcacccgc      180

tacggaagca ggatcgagag agagcagcac cacctgatcg agtctatcga gaagagcacc      240

cagtacatgg ccaagaggag aatcggcgcc ctgatctccg tggctcggga tacaggaatg      300

gacgattaca tcgagacagg catccccctg aacgctaaga tcagctccca gctgctgatc      360

aacatcttca tccccaacac acctctgcac gacggagccg tgatcatcaa gggcaacgag      420

atcgctagcg ccgcttccta cctgccactg agcgattccc cctttctgag caaggagctg      480

ggaaccaggc acagggccgc tctgggcatc tctgaggtga ccgacagcat cacaatcgtg      540

gtgtctgagg agacaggcgg aatcagcctg accaagggcg gagagctgtt ccgcgacgtg      600

agcgaggagg agctgcacaa gatcctgctg aaggagctgg tgaccgtgac agccaagaag      660

ccctctatct ttagcaagtg gaagggcgga aagtccgag                             699


<210>  6
<211>  233
<212>  PRT
<213>  Listeria Monocytogenes

<400>  6

Met Lys Gly Ile Phe Ile Ile Ile Ala Val Lys Leu Leu Ser Gly Phe 
1               5                   10                  15      


Phe Gly Leu Gln Thr Val Glu Trp Ile Thr Asp Gln Met Leu Thr Trp 
            20                  25                  30          


Gly Phe Leu Ala Ile Ile Ile Ile Phe Gln Pro Glu Leu Arg Arg Ala 
        35                  40                  45              


Leu Glu Thr Leu Gly Arg Gly Asn Ile Phe Thr Arg Tyr Gly Ser Arg 
    50                  55                  60                  


Ile Glu Arg Glu Gln His His Leu Ile Glu Ser Ile Glu Lys Ser Thr 
65                  70                  75                  80  


Gln Tyr Met Ala Lys Arg Arg Ile Gly Ala Leu Ile Ser Val Ala Arg 
                85                  90                  95      


Asp Thr Gly Met Asp Asp Tyr Ile Glu Thr Gly Ile Pro Leu Asn Ala 
            100                 105                 110         


Lys Ile Ser Ser Gln Leu Leu Ile Asn Ile Phe Ile Pro Asn Thr Pro 
        115                 120                 125             


Leu His Asp Gly Ala Val Ile Ile Lys Gly Asn Glu Ile Ala Ser Ala 
    130                 135                 140                 


Ala Ser Tyr Leu Pro Leu Ser Asp Ser Pro Phe Leu Ser Lys Glu Leu 
145                 150                 155                 160 


Gly Thr Arg His Arg Ala Ala Leu Gly Ile Ser Glu Val Thr Asp Ser 
                165                 170                 175     


Ile Thr Ile Val Val Ser Glu Glu Thr Gly Gly Ile Ser Leu Thr Lys 
            180                 185                 190         


Gly Gly Glu Leu Phe Arg Asp Val Ser Glu Glu Glu Leu His Lys Ile 
        195                 200                 205             


Leu Leu Lys Glu Leu Val Thr Val Thr Ala Lys Lys Pro Ser Ile Phe 
    210                 215                 220                 


Ser Lys Trp Lys Gly Gly Lys Ser Glu 
225                 230             


<210>  7
<211>  1539
<212>  DNA
<213>  Vibrio cholerae

<400>  7
atgaatctga ataacttctc cctgcggtgg ctgactactc tgaatgctct ggctgtggtc       60

ctgggctttc tgatgtttta cctgactttc aagtattttt ggtcccacga tagagaggtg      120

gcacaggtgc tgcagctgca gcaggccgag ctgcagcggg tggagacact gctgtccctg      180

gagagaaagg ccatgggagc ctctctggca gactatgcag catgggatga gatggcagat      240

ttcatcgcaa agcccaccct ggagtttaca cagtccaata ttggagaaca cgccttcagc      300

tcccagtttc tggacggcgt gttcatctac gatcctgagg gcaatctggt gtggggcaag      360

aagtatgatg cagcaacagg acagtctagc tcctatgagc acctgctgcc agactttagc      420

agaatcctgc agcaggcaac cagactgtct gtggatgaga tcagcacatc cgtgcggtac      480

atggtggtgg aggatgaacc atatctggca gcaacagcaa gagtgtgcga ctctgatggc      540

aagggatgta acaagggctt cctgatcttt atcaagaagg tgagggccca gtttgcaaat      600

gtggtggagc aggcaacagg agtggatatt gaggtgctga catgcaagaa tgatgcccca      660

ctgccacagg atgaggtgga cgtgagctac atcaagcagc tggactatag cggcaactct      720

agcgtgctgt tcaagatcaa tcaccacatc aagcaccctc ccttcatcag aacagaggag      780

atcctggccc tgctgttctt ttccctggtc atgtacctgg tgaatctgtg ggtggtcatc      840

gccctgatca agcctatcac cacagcctct caggtgctgc agcagttcaa gacctccggc      900

ggcaagatgc cagatgcatc tacattcatc tcctctgaga tgaaggagtt tgccaccaca      960

atcaacagaa ttgtgggaca gctggaggat tctcagcagg tgctgaggtg gcagtctgag     1020

cacgacccac tgacaagaat ctccaatcgg agacacctgg agaagcagct gaagtcttac     1080

ctgtctgaca gacctcaggc ctatctggtg ctgtttctgg tggacatcga tttctttaag     1140

cggttcaacg acagctttgg ccacctggca ggcgatgagg ccctgtgcag cgtggccgac     1200

gtgctgcagt ccgtggagtt ccacggagag aagattgtgg caagatttgg cggcgaggag     1260

ttttgcgtgg tgctggcatc tgactgtgcc tttgatgccg agcagtatgc ccagcagatg     1320

agaagcaaga ttgagcagct ggcaattgca aatcctgtgg atgcactgtg ccagtacctg     1380

accgtgtcta ttggcggcgt gtatgcaatc agccctaaga tggagtccta cctgtctctg     1440

ttccaccagg cagacatggc cctgtaccac gccaaggagc atgggagaga cagatacgtg     1500

gtgcggaact tcgtggatta caaagatgat gatgataaa                            1539


<210>  8
<211>  513
<212>  PRT
<213>  Vibrio cholerae

<400>  8

Met Asn Leu Asn Asn Phe Ser Leu Arg Trp Leu Thr Thr Leu Asn Ala 
1               5                   10                  15      


Leu Ala Val Val Leu Gly Phe Leu Met Phe Tyr Leu Thr Phe Lys Tyr 
            20                  25                  30          


Phe Trp Ser His Asp Arg Glu Val Ala Gln Val Leu Gln Leu Gln Gln 
        35                  40                  45              


Ala Glu Leu Gln Arg Val Glu Thr Leu Leu Ser Leu Glu Arg Lys Ala 
    50                  55                  60                  


Met Gly Ala Ser Leu Ala Asp Tyr Ala Ala Trp Asp Glu Met Ala Asp 
65                  70                  75                  80  


Phe Ile Ala Lys Pro Thr Leu Glu Phe Thr Gln Ser Asn Ile Gly Glu 
                85                  90                  95      


His Ala Phe Ser Ser Gln Phe Leu Asp Gly Val Phe Ile Tyr Asp Pro 
            100                 105                 110         


Glu Gly Asn Leu Val Trp Gly Lys Lys Tyr Asp Ala Ala Thr Gly Gln 
        115                 120                 125             


Ser Ser Ser Tyr Glu His Leu Leu Pro Asp Phe Ser Arg Ile Leu Gln 
    130                 135                 140                 


Gln Ala Thr Arg Leu Ser Val Asp Glu Ile Ser Thr Ser Val Arg Tyr 
145                 150                 155                 160 


Met Val Val Glu Asp Glu Pro Tyr Leu Ala Ala Thr Ala Arg Val Cys 
                165                 170                 175     


Asp Ser Asp Gly Lys Gly Cys Asn Lys Gly Phe Leu Ile Phe Ile Lys 
            180                 185                 190         


Lys Val Arg Ala Gln Phe Ala Asn Val Val Glu Gln Ala Thr Gly Val 
        195                 200                 205             


Asp Ile Glu Val Leu Thr Cys Lys Asn Asp Ala Pro Leu Pro Gln Asp 
    210                 215                 220                 


Glu Val Asp Val Ser Tyr Ile Lys Gln Leu Asp Tyr Ser Gly Asn Ser 
225                 230                 235                 240 


Ser Val Leu Phe Lys Ile Asn His His Ile Lys His Pro Pro Phe Ile 
                245                 250                 255     


Arg Thr Glu Glu Ile Leu Ala Leu Leu Phe Phe Ser Leu Val Met Tyr 
            260                 265                 270         


Leu Val Asn Leu Trp Val Val Ile Ala Leu Ile Lys Pro Ile Thr Thr 
        275                 280                 285             


Ala Ser Gln Val Leu Gln Gln Phe Lys Thr Ser Gly Gly Lys Met Pro 
    290                 295                 300                 


Asp Ala Ser Thr Phe Ile Ser Ser Glu Met Lys Glu Phe Ala Thr Thr 
305                 310                 315                 320 


Ile Asn Arg Ile Val Gly Gln Leu Glu Asp Ser Gln Gln Val Leu Arg 
                325                 330                 335     


Trp Gln Ser Glu His Asp Pro Leu Thr Arg Ile Ser Asn Arg Arg His 
            340                 345                 350         


Leu Glu Lys Gln Leu Lys Ser Tyr Leu Ser Asp Arg Pro Gln Ala Tyr 
        355                 360                 365             


Leu Val Leu Phe Leu Val Asp Ile Asp Phe Phe Lys Arg Phe Asn Asp 
    370                 375                 380                 


Ser Phe Gly His Leu Ala Gly Asp Glu Ala Leu Cys Ser Val Ala Asp 
385                 390                 395                 400 


Val Leu Gln Ser Val Glu Phe His Gly Glu Lys Ile Val Ala Arg Phe 
                405                 410                 415     


Gly Gly Glu Glu Phe Cys Val Val Leu Ala Ser Asp Cys Ala Phe Asp 
            420                 425                 430         


Ala Glu Gln Tyr Ala Gln Gln Met Arg Ser Lys Ile Glu Gln Leu Ala 
        435                 440                 445             


Ile Ala Asn Pro Val Asp Ala Leu Cys Gln Tyr Leu Thr Val Ser Ile 
    450                 455                 460                 


Gly Gly Val Tyr Ala Ile Ser Pro Lys Met Glu Ser Tyr Leu Ser Leu 
465                 470                 475                 480 


Phe His Gln Ala Asp Met Ala Leu Tyr His Ala Lys Glu His Gly Arg 
                485                 490                 495     


Asp Arg Tyr Val Val Arg Asn Phe Val Asp Tyr Lys Asp Asp Asp Asp 
            500                 505                 510         


Lys 
    


<210>  9
<211>  1539
<212>  DNA
<213>  Vibrio cholerae

<400>  9
atgaatctga ataacttctc tctgcggtgg ctgacaactc tgaatgctct ggctgtggtc       60

ctgggctttc tgatgttcta cctgacattc aagtattttt ggtcccacga tagagaggtg      120

gcacaggtgc tgcagctgca gcaggccgag ctgcagcggg tggagacact gctgtccctg      180

gagagaaagg ccatgggagc ctctctggca gactatgcag catgggatga gatggcagat      240

ttcatcgcaa agcccaccct ggagtttaca cagtccaata ttggagaaca cgccttcagc      300

tcccagtttc tggacggcgt gttcatctac gatcctgagg gcaatctggt gtggggcaag      360

aagtatgatg cagcaacagg acagtctagc tcctatgagc acctgctgcc agactttagc      420

agaatcctgc agcaggcaac cagactgtct gtggatgaga tcagcacatc cgtgcggtac      480

atggtggtgg aggatgagcc ttatctggca gcaacagcag ccgtgtgcgc atctgatggc      540

aagggatgta acaagggctt cctgatcttt atcaagaagg tgagagccca gtttgcaaat      600

gtggtggagc aggcaacagg agtggatatt gaggtgctga catgcaagaa tgatgcccca      660

ctgccacagg atgaggtgga cgtgagctac atcaagcagc tggactatag cggcaactct      720

agcgtgctgt tcaagatcaa tcaccacatc aagcaccctc ccttcatcag gacagaggag      780

atcctggccc tgctgttctt ttccctggtc atgtacctgg tgaatctgtg ggtggtcatc      840

gccctgatca agcctatcac cacagcctct caggtgctgc agcagttcaa gacctccggc      900

ggcaagatgc cagatgcatc tacattcatc tcctctgaga tgaaggagtt tgcaacaaca      960

atcaacagaa ttgtgggaca gctggaggat tctcagcagg tgctgaggtg gcagtctgag     1020

cacgacccac tgacaagaat ctccaatcgg agacacctgg agaagcagct gaagtcttac     1080

ctgtctgaca gaccacaggc ctatctggtg ctgtttctgg tggacatcga tttctttaag     1140

agattcaacg acagctttgg ccacctggca ggcgatgccg ccctgtgcag cgtggccgac     1200

gtgctgcagt ctgtggagtt ccacggagag aagattgtgg caaggtttgg cggcgaggag     1260

ttttgcgtgg tgctggcatc tgactgtgcc tttgatgcag agcagtatgc acagcagatg     1320

cgcagcaaga ttgagcagct ggcaattgca aatcctgtgg atgcactgtg ccagtacctg     1380

accgtgtcta ttggcggcgt gtatgcaatc agccctaaga tggagtccta cctgtctctg     1440

ttccaccagg cagacatggc cctgtaccac gccaaggagc atgggcggga cagatacgtg     1500

gtgcggaact tcgtggatta caaagatgat gatgataaa                            1539


<210>  10
<211>  513
<212>  PRT
<213>  Vibrio cholerae

<400>  10

Met Asn Leu Asn Asn Phe Ser Leu Arg Trp Leu Thr Thr Leu Asn Ala 
1               5                   10                  15      


Leu Ala Val Val Leu Gly Phe Leu Met Phe Tyr Leu Thr Phe Lys Tyr 
            20                  25                  30          


Phe Trp Ser His Asp Arg Glu Val Ala Gln Val Leu Gln Leu Gln Gln 
        35                  40                  45              


Ala Glu Leu Gln Arg Val Glu Thr Leu Leu Ser Leu Glu Arg Lys Ala 
    50                  55                  60                  


Met Gly Ala Ser Leu Ala Asp Tyr Ala Ala Trp Asp Glu Met Ala Asp 
65                  70                  75                  80  


Phe Ile Ala Lys Pro Thr Leu Glu Phe Thr Gln Ser Asn Ile Gly Glu 
                85                  90                  95      


His Ala Phe Ser Ser Gln Phe Leu Asp Gly Val Phe Ile Tyr Asp Pro 
            100                 105                 110         


Glu Gly Asn Leu Val Trp Gly Lys Lys Tyr Asp Ala Ala Thr Gly Gln 
        115                 120                 125             


Ser Ser Ser Tyr Glu His Leu Leu Pro Asp Phe Ser Arg Ile Leu Gln 
    130                 135                 140                 


Gln Ala Thr Arg Leu Ser Val Asp Glu Ile Ser Thr Ser Val Arg Tyr 
145                 150                 155                 160 


Met Val Val Glu Asp Glu Pro Tyr Leu Ala Ala Thr Ala Ala Val Cys 
                165                 170                 175     


Ala Ser Asp Gly Lys Gly Cys Asn Lys Gly Phe Leu Ile Phe Ile Lys 
            180                 185                 190         


Lys Val Arg Ala Gln Phe Ala Asn Val Val Glu Gln Ala Thr Gly Val 
        195                 200                 205             


Asp Ile Glu Val Leu Thr Cys Lys Asn Asp Ala Pro Leu Pro Gln Asp 
    210                 215                 220                 


Glu Val Asp Val Ser Tyr Ile Lys Gln Leu Asp Tyr Ser Gly Asn Ser 
225                 230                 235                 240 


Ser Val Leu Phe Lys Ile Asn His His Ile Lys His Pro Pro Phe Ile 
                245                 250                 255     


Arg Thr Glu Glu Ile Leu Ala Leu Leu Phe Phe Ser Leu Val Met Tyr 
            260                 265                 270         


Leu Val Asn Leu Trp Val Val Ile Ala Leu Ile Lys Pro Ile Thr Thr 
        275                 280                 285             


Ala Ser Gln Val Leu Gln Gln Phe Lys Thr Ser Gly Gly Lys Met Pro 
    290                 295                 300                 


Asp Ala Ser Thr Phe Ile Ser Ser Glu Met Lys Glu Phe Ala Thr Thr 
305                 310                 315                 320 


Ile Asn Arg Ile Val Gly Gln Leu Glu Asp Ser Gln Gln Val Leu Arg 
                325                 330                 335     


Trp Gln Ser Glu His Asp Pro Leu Thr Arg Ile Ser Asn Arg Arg His 
            340                 345                 350         


Leu Glu Lys Gln Leu Lys Ser Tyr Leu Ser Asp Arg Pro Gln Ala Tyr 
        355                 360                 365             


Leu Val Leu Phe Leu Val Asp Ile Asp Phe Phe Lys Arg Phe Asn Asp 
    370                 375                 380                 


Ser Phe Gly His Leu Ala Gly Asp Ala Ala Leu Cys Ser Val Ala Asp 
385                 390                 395                 400 


Val Leu Gln Ser Val Glu Phe His Gly Glu Lys Ile Val Ala Arg Phe 
                405                 410                 415     


Gly Gly Glu Glu Phe Cys Val Val Leu Ala Ser Asp Cys Ala Phe Asp 
            420                 425                 430         


Ala Glu Gln Tyr Ala Gln Gln Met Arg Ser Lys Ile Glu Gln Leu Ala 
        435                 440                 445             


Ile Ala Asn Pro Val Asp Ala Leu Cys Gln Tyr Leu Thr Val Ser Ile 
    450                 455                 460                 


Gly Gly Val Tyr Ala Ile Ser Pro Lys Met Glu Ser Tyr Leu Ser Leu 
465                 470                 475                 480 


Phe His Gln Ala Asp Met Ala Leu Tyr His Ala Lys Glu His Gly Arg 
                485                 490                 495     


Asp Arg Tyr Val Val Arg Asn Phe Val Asp Tyr Lys Asp Asp Asp Asp 
            500                 505                 510         


Lys 
    


<210>  11
<211>  1002
<212>  DNA
<213>  Vibrio cholerae

<400>  11
atgaacgata aggtcctgga gagcgtgatt gagattaccg aacagaaaaa tagtctggca       60

ctgagctaca gcatcctggc aacactgtct gagctgctgc ctctgagcac agccacactg      120

ttccaccacc tgggcaggag caccctgatg gtggcaagac tgatcatcac aaagaatgca      180

gcaggcaaga aggagtatca gtggcagtat gatcaggtgt gcgcagataa tggataccag      240

cactcccagt ctgagatggc cttttcccag caggccaatg gccagtatca gtgcttctgt      300

cccatcccta tcgaggagca cttttctgcc gagctgtgcc tgatcctgaa caaggaccca      360

gagccctaca ggatgctgat caacggcttc gccaagatct accgcaatta taccgtgatc      420

ctgcacgagt ctgagagaga caagctgaca ggcctgctga atagaagaac actggaggat      480

cggctgagac acacctttgc catcaaccca tccacagagg agaatcacaa gctgtggatc      540

gccatgctgg acatcgatca cttcaaggcc atcaatgacc actttggcca catgatcggc      600

gatgagatcc tgctgatgtt cgcccagcag atgcagcact attttggacc tagctcccag      660

ctgttccggt ttggcggcga ggagttcgtg atcatctttt cttctggaaa tgagccacag      720

atcaagcagc agctggatgg cttccggcag cagatcaggc gccacaattt tcctaggatt      780

ggagagctga gcttctccgc cggattttgt tctctgcggc ccggcgatta cctgccaaca      840

atcctggacc acgccgataa ggccctgtac tatgcaaaag agcacggaag gaaccaggtg      900

cactgctatg agcagctgtg cgagaatggc aagatcgcct ccgcccagcg accattctcc      960

gatgatgtgg aactgtttga ctacaaggat gacgatgata aa                        1002


<210>  12
<211>  334
<212>  PRT
<213>  Vibrio cholerae

<400>  12

Met Asn Asp Lys Val Leu Glu Ser Val Ile Glu Ile Thr Glu Gln Lys 
1               5                   10                  15      


Asn Ser Leu Ala Leu Ser Tyr Ser Ile Leu Ala Thr Leu Ser Glu Leu 
            20                  25                  30          


Leu Pro Leu Ser Thr Ala Thr Leu Phe His His Leu Gly Arg Ser Thr 
        35                  40                  45              


Leu Met Val Ala Arg Leu Ile Ile Thr Lys Asn Ala Ala Gly Lys Lys 
    50                  55                  60                  


Glu Tyr Gln Trp Gln Tyr Asp Gln Val Cys Ala Asp Asn Gly Tyr Gln 
65                  70                  75                  80  


His Ser Gln Ser Glu Met Ala Phe Ser Gln Gln Ala Asn Gly Gln Tyr 
                85                  90                  95      


Gln Cys Phe Cys Pro Ile Pro Ile Glu Glu His Phe Ser Ala Glu Leu 
            100                 105                 110         


Cys Leu Ile Leu Asn Lys Asp Pro Glu Pro Tyr Arg Met Leu Ile Asn 
        115                 120                 125             


Gly Phe Ala Lys Ile Tyr Arg Asn Tyr Thr Val Ile Leu His Glu Ser 
    130                 135                 140                 


Glu Arg Asp Lys Leu Thr Gly Leu Leu Asn Arg Arg Thr Leu Glu Asp 
145                 150                 155                 160 


Arg Leu Arg His Thr Phe Ala Ile Asn Pro Ser Thr Glu Glu Asn His 
                165                 170                 175     


Lys Leu Trp Ile Ala Met Leu Asp Ile Asp His Phe Lys Ala Ile Asn 
            180                 185                 190         


Asp His Phe Gly His Met Ile Gly Asp Glu Ile Leu Leu Met Phe Ala 
        195                 200                 205             


Gln Gln Met Gln His Tyr Phe Gly Pro Ser Ser Gln Leu Phe Arg Phe 
    210                 215                 220                 


Gly Gly Glu Glu Phe Val Ile Ile Phe Ser Ser Gly Asn Glu Pro Gln 
225                 230                 235                 240 


Ile Lys Gln Gln Leu Asp Gly Phe Arg Gln Gln Ile Arg Arg His Asn 
                245                 250                 255     


Phe Pro Arg Ile Gly Glu Leu Ser Phe Ser Ala Gly Phe Cys Ser Leu 
            260                 265                 270         


Arg Pro Gly Asp Tyr Leu Pro Thr Ile Leu Asp His Ala Asp Lys Ala 
        275                 280                 285             


Leu Tyr Tyr Ala Lys Glu His Gly Arg Asn Gln Val His Cys Tyr Glu 
    290                 295                 300                 


Gln Leu Cys Glu Asn Gly Lys Ile Ala Ser Ala Gln Arg Pro Phe Ser 
305                 310                 315                 320 


Asp Asp Val Glu Leu Phe Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 330                 


<210>  13
<211>  1002
<212>  DNA
<213>  Vibrio cholerae

<400>  13
atgaacgaca aggtcctgga gagcgtgatt gagattaccg agcagaaaaa cagcctggcc       60

ctgagctaca gcatcctggc aaccctgtct gagctgctgc ctctgagcac agccacactg      120

ttccaccacc tgggcaggag caccctgatg gtggcaagac tgatcatcac aaagaatgca      180

gcaggcaaga aggagtatca gtggcagtat gatcaggtgt gcgcagataa tggataccag      240

cactcccagt ctgagatggc cttttcccag caggccaatg gccagtatca gtgcttctgt      300

cccatcccta tcgaggagca cttttctgcc gagctgtgcc tgatcctgaa caaggaccca      360

gagccctaca ggatgctgat caacggcttc gccaagatct accgcaatta taccgtgatc      420

ctgcacgagt ctgagagaga caagctgaca ggcctgctga atagaagaac actggaggat      480

cggctgagac acacctttgc catcaaccca tccacagagg agaatcacaa gctgtggatc      540

gccatgctgg acatcgatca cttcaaggcc atcaatgacc actttggcca catgatcggc      600

gatgagatcc tgctgatgtt cgcccagcag atgcagcact attttggacc ttctagccag      660

ctgttcagat ttggcggcga ggagttcgtg atcatctttt cttctggaaa tgagccacag      720

atcaagcagc agctggatgg cttccggcag cagatcaggc gccacaattt tcctaggatt      780

ggagagctga gcttctccgc cggattttgc tctctggcac ctggggcata cctgccaaca      840

atcctggacc acgccgataa ggccctgtac tatgcaaaag agcacggaag aaaccaggtg      900

cactgctatg agcagctgtg cgagaatggc aagatcgcct ccgcccagag accattttca      960

gatgatgtgg aactgtttga ttacaaggac gacgacgata aa                        1002


<210>  14
<211>  334
<212>  PRT
<213>  Vibrio cholerae

<400>  14

Met Asn Asp Lys Val Leu Glu Ser Val Ile Glu Ile Thr Glu Gln Lys 
1               5                   10                  15      


Asn Ser Leu Ala Leu Ser Tyr Ser Ile Leu Ala Thr Leu Ser Glu Leu 
            20                  25                  30          


Leu Pro Leu Ser Thr Ala Thr Leu Phe His His Leu Gly Arg Ser Thr 
        35                  40                  45              


Leu Met Val Ala Arg Leu Ile Ile Thr Lys Asn Ala Ala Gly Lys Lys 
    50                  55                  60                  


Glu Tyr Gln Trp Gln Tyr Asp Gln Val Cys Ala Asp Asn Gly Tyr Gln 
65                  70                  75                  80  


His Ser Gln Ser Glu Met Ala Phe Ser Gln Gln Ala Asn Gly Gln Tyr 
                85                  90                  95      


Gln Cys Phe Cys Pro Ile Pro Ile Glu Glu His Phe Ser Ala Glu Leu 
            100                 105                 110         


Cys Leu Ile Leu Asn Lys Asp Pro Glu Pro Tyr Arg Met Leu Ile Asn 
        115                 120                 125             


Gly Phe Ala Lys Ile Tyr Arg Asn Tyr Thr Val Ile Leu His Glu Ser 
    130                 135                 140                 


Glu Arg Asp Lys Leu Thr Gly Leu Leu Asn Arg Arg Thr Leu Glu Asp 
145                 150                 155                 160 


Arg Leu Arg His Thr Phe Ala Ile Asn Pro Ser Thr Glu Glu Asn His 
                165                 170                 175     


Lys Leu Trp Ile Ala Met Leu Asp Ile Asp His Phe Lys Ala Ile Asn 
            180                 185                 190         


Asp His Phe Gly His Met Ile Gly Asp Glu Ile Leu Leu Met Phe Ala 
        195                 200                 205             


Gln Gln Met Gln His Tyr Phe Gly Pro Ser Ser Gln Leu Phe Arg Phe 
    210                 215                 220                 


Gly Gly Glu Glu Phe Val Ile Ile Phe Ser Ser Gly Asn Glu Pro Gln 
225                 230                 235                 240 


Ile Lys Gln Gln Leu Asp Gly Phe Arg Gln Gln Ile Arg Arg His Asn 
                245                 250                 255     


Phe Pro Arg Ile Gly Glu Leu Ser Phe Ser Ala Gly Phe Cys Ser Leu 
            260                 265                 270         


Ala Pro Gly Ala Tyr Leu Pro Thr Ile Leu Asp His Ala Asp Lys Ala 
        275                 280                 285             


Leu Tyr Tyr Ala Lys Glu His Gly Arg Asn Gln Val His Cys Tyr Glu 
    290                 295                 300                 


Gln Leu Cys Glu Asn Gly Lys Ile Ala Ser Ala Gln Arg Pro Phe Ser 
305                 310                 315                 320 


Asp Asp Val Glu Leu Phe Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 330                 


<210>  15
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VCA0848 (human albumin preproprotein signal peptide added at 
       N-terminus) DNA sequence

<400>  15
atgaagtggg tgacctttat ctctctgctg tttctgtttt cctctgccta ttctatgaac       60

gacaaagtgc tggagtccgt gattgagatt acagagcaga agaacagcct ggccctgtcc      120

tactctatcc tggccacact gtctgagctg ctgcctctgt ctacagccac actgtttcac      180

cacctgggca ggtctaccct gatggtggca cgcctgatca tcacaaagaa tgcagcaggc      240

aagaaggagt atcagtggca gtatgatcag gtgtgcgcag ataatggata ccagcactct      300

cagtctgaga tggcctttag ccagcaggcc aatggccagt atcagtgctt ctgtcccatc      360

cctattgagg agcacttttc cgccgagctg tgcctgatcc tgaacaagga cccagagccc      420

tacaggatgc tgatcaacgg cttcgccaag atctaccgca attataccgt gatcctgcac      480

gagtctgaga gagacaagct gacaggcctg ctgaatagaa gaacactgga ggatcggctg      540

agacacacct ttgccatcaa cccaagcaca gaggagaatc acaagctgtg gatcgccatg      600

ctggacatcg atcacttcaa ggccatcaac gaccactttg gccacatgat cggcgatgag      660

atcctgctga tgttcgccca gcagatgcag cactattttg gacctagctc ccagctgttc      720

cggtttggcg gcgaggagtt cgtgatcatc ttttcttctg gaaatgagcc acagatcaag      780

cagcagctgg atggcttccg gcagcagatc aggcgccaca attttcctag gattggagag      840

ctgtctttca gcgccggatt ttgcagcctg cggcccggcg attacctgcc aacaatcctg      900

gaccacgccg ataaggccct gtactatgca aaagagcacg gaaggaacca ggtgcactgc      960

tatgagcagc tgtgcgagaa tggcaagatc gcctccgccc agagaccatt ttcagatgat     1020

gtggaactgt ttgactacaa ggatgatgat gataag                               1056


<210>  16
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VCA0848 (human albumin preproprotein signal peptide added at 
       N-terminus)

<400>  16

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Met Asn Asp Lys Val Leu Glu Ser Val Ile Glu Ile Thr Glu 
            20                  25                  30          


Gln Lys Asn Ser Leu Ala Leu Ser Tyr Ser Ile Leu Ala Thr Leu Ser 
        35                  40                  45              


Glu Leu Leu Pro Leu Ser Thr Ala Thr Leu Phe His His Leu Gly Arg 
    50                  55                  60                  


Ser Thr Leu Met Val Ala Arg Leu Ile Ile Thr Lys Asn Ala Ala Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Gln Trp Gln Tyr Asp Gln Val Cys Ala Asp Asn Gly 
                85                  90                  95      


Tyr Gln His Ser Gln Ser Glu Met Ala Phe Ser Gln Gln Ala Asn Gly 
            100                 105                 110         


Gln Tyr Gln Cys Phe Cys Pro Ile Pro Ile Glu Glu His Phe Ser Ala 
        115                 120                 125             


Glu Leu Cys Leu Ile Leu Asn Lys Asp Pro Glu Pro Tyr Arg Met Leu 
    130                 135                 140                 


Ile Asn Gly Phe Ala Lys Ile Tyr Arg Asn Tyr Thr Val Ile Leu His 
145                 150                 155                 160 


Glu Ser Glu Arg Asp Lys Leu Thr Gly Leu Leu Asn Arg Arg Thr Leu 
                165                 170                 175     


Glu Asp Arg Leu Arg His Thr Phe Ala Ile Asn Pro Ser Thr Glu Glu 
            180                 185                 190         


Asn His Lys Leu Trp Ile Ala Met Leu Asp Ile Asp His Phe Lys Ala 
        195                 200                 205             


Ile Asn Asp His Phe Gly His Met Ile Gly Asp Glu Ile Leu Leu Met 
    210                 215                 220                 


Phe Ala Gln Gln Met Gln His Tyr Phe Gly Pro Ser Ser Gln Leu Phe 
225                 230                 235                 240 


Arg Phe Gly Gly Glu Glu Phe Val Ile Ile Phe Ser Ser Gly Asn Glu 
                245                 250                 255     


Pro Gln Ile Lys Gln Gln Leu Asp Gly Phe Arg Gln Gln Ile Arg Arg 
            260                 265                 270         


His Asn Phe Pro Arg Ile Gly Glu Leu Ser Phe Ser Ala Gly Phe Cys 
        275                 280                 285             


Ser Leu Arg Pro Gly Asp Tyr Leu Pro Thr Ile Leu Asp His Ala Asp 
    290                 295                 300                 


Lys Ala Leu Tyr Tyr Ala Lys Glu His Gly Arg Asn Gln Val His Cys 
305                 310                 315                 320 


Tyr Glu Gln Leu Cys Glu Asn Gly Lys Ile Ala Ser Ala Gln Arg Pro 
                325                 330                 335     


Phe Ser Asp Asp Val Glu Leu Phe Asp Tyr Lys Asp Asp Asp Asp Lys 
            340                 345                 350         


<210>  17
<211>  1047
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  17
atgctggctt gtcctctgcc ccctgacgaa gctctgagac agcaggctct ggatgatatg       60

gctctggtgg atacccccgc cgaacactac ctggatgcac tggtggagct ggcaagagag      120

acattcggcg tgaagacagt gctgatctcc ctgatcgacc acgataggca gtggtttaaa      180

gcaagaattg gcctggatgc agagcagacc ccacgggatc tgtccttctg cggccacgcc      240

atcctggcct ctgagcccct gatggtgacc gacgccagcc gggacccccg ctttcacgat      300

aatcctctgg tgacaggccc tcccttcatc cggttctacg caggagagcc actgcacgcc      360

tctaatggcc aggccatcgg caccctgtgc ctgatcgacc caagcccccg gctgctggat      420

ctgagagagg gcagacagct gaacaggctg agcatcctgg cagagggata tctgcagctg      480

aggtccctga cagagcacac aaggtttctg agacaggaga ttgatagaga gcagaggaag      540

tctctgctgg accccctgac ccagctgtgg aacagagccg gcttccacgc cctgcaccag      600

cacgagctgg agctggcaag agcctccgac cagagaatcg gcatcatcta ctctgacatc      660

gatcacttca agaggatcaa tgacacactg ggccaccggg ccggcgattc tgtgctgagg      720

gaggcagcaa gcagactgag agccgccctg aggcctgagg acctgctggc ccgcttcggc      780

ggcgaggaat tcgtggcaat ggtgagggtg cgcgagacaa cagagctgac catgatcgcc      840

aatcggatca gagagctgat ggaggcaaca ccaatcgatt gcgccggcac cagcgtgcct      900

gtgacaatct ccgccggctg taccctggcc ggctccggcg aggagccaga gagggccctg      960

gcccgcgccg acgccgccct gtatgatgcc aagcgagcag gacggaaccg agtggtctct     1020

gtggactaca aggacgatga cgacaag                                         1047


<210>  18
<211>  349
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  18

Met Leu Ala Cys Pro Leu Pro Pro Asp Glu Ala Leu Arg Gln Gln Ala 
1               5                   10                  15      


Leu Asp Asp Met Ala Leu Val Asp Thr Pro Ala Glu His Tyr Leu Asp 
            20                  25                  30          


Ala Leu Val Glu Leu Ala Arg Glu Thr Phe Gly Val Lys Thr Val Leu 
        35                  40                  45              


Ile Ser Leu Ile Asp His Asp Arg Gln Trp Phe Lys Ala Arg Ile Gly 
    50                  55                  60                  


Leu Asp Ala Glu Gln Thr Pro Arg Asp Leu Ser Phe Cys Gly His Ala 
65                  70                  75                  80  


Ile Leu Ala Ser Glu Pro Leu Met Val Thr Asp Ala Ser Arg Asp Pro 
                85                  90                  95      


Arg Phe His Asp Asn Pro Leu Val Thr Gly Pro Pro Phe Ile Arg Phe 
            100                 105                 110         


Tyr Ala Gly Glu Pro Leu His Ala Ser Asn Gly Gln Ala Ile Gly Thr 
        115                 120                 125             


Leu Cys Leu Ile Asp Pro Ser Pro Arg Leu Leu Asp Leu Arg Glu Gly 
    130                 135                 140                 


Arg Gln Leu Asn Arg Leu Ser Ile Leu Ala Glu Gly Tyr Leu Gln Leu 
145                 150                 155                 160 


Arg Ser Leu Thr Glu His Thr Arg Phe Leu Arg Gln Glu Ile Asp Arg 
                165                 170                 175     


Glu Gln Arg Lys Ser Leu Leu Asp Pro Leu Thr Gln Leu Trp Asn Arg 
            180                 185                 190         


Ala Gly Phe His Ala Leu His Gln His Glu Leu Glu Leu Ala Arg Ala 
        195                 200                 205             


Ser Asp Gln Arg Ile Gly Ile Ile Tyr Ser Asp Ile Asp His Phe Lys 
    210                 215                 220                 


Arg Ile Asn Asp Thr Leu Gly His Arg Ala Gly Asp Ser Val Leu Arg 
225                 230                 235                 240 


Glu Ala Ala Ser Arg Leu Arg Ala Ala Leu Arg Pro Glu Asp Leu Leu 
                245                 250                 255     


Ala Arg Phe Gly Gly Glu Glu Phe Val Ala Met Val Arg Val Arg Glu 
            260                 265                 270         


Thr Thr Glu Leu Thr Met Ile Ala Asn Arg Ile Arg Glu Leu Met Glu 
        275                 280                 285             


Ala Thr Pro Ile Asp Cys Ala Gly Thr Ser Val Pro Val Thr Ile Ser 
    290                 295                 300                 


Ala Gly Cys Thr Leu Ala Gly Ser Gly Glu Glu Pro Glu Arg Ala Leu 
305                 310                 315                 320 


Ala Arg Ala Asp Ala Ala Leu Tyr Asp Ala Lys Arg Ala Gly Arg Asn 
                325                 330                 335     


Arg Val Val Ser Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            340                 345                 


<210>  19
<211>  1047
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  19
atgctggctt gccctctgcc ccctgacgcc gcactgagac agcaggctct ggatgatatg       60

gctctggtgg atacccccgc cgaacactac ctggatgcac tggtggagct ggcaagagag      120

acattcggcg tgaagacagt gctgatctcc ctgatcgacc acgataggca gtggtttaaa      180

gcaagaattg gcctggatgc agagcagacc ccaagagatc tgtccttctg tggacacgca      240

atcctggcat ctgagccact gatggtgacc gacgccagcc gggaccccgc ctttcacgca      300

aatcctctgg tgacaggccc tcccttcatc cgcttttacg caggagagcc actgcacgcc      360

tctaatggcc aggccatcgg caccctgtgc ctgatcgatc catctcccgc cctgctggcc      420

ctgagggagg gccgccagct gaaccggctg agcatcctgg cagagggata tctgcagctg      480

agatccctga cagagcacac acggtttctg aggcaggaga ttgacaggga gcagagaaag      540

tctctgctgg accccctgac ccagctgtgg aacagggccg gcttccacgc cctgcaccag      600

cacgaactgg agctggcagc agcatccgcc cagagaattg gaatcatcta ctctgacatc      660

gatcacttca aggccatcaa tgccacactg ggacacgcag caggagcatc tgtgctgcgg      720

gaggccgcca gccggctgag agccgccctg gcccctgagg ccctgctggc caggtttggc      780

ggcgaggaat tcgtggcaat ggtgagggtg cgcgagacaa cagagctgac catgatcgcc      840

aatcggatca gagagctgat ggaggcaaca ccaatcgact gcgccggcac cagcgtgcct      900

gtgacaatct ccgccggctg taccctggcc ggctccggcg aggagccaga gcgggccctg      960

gccagagccg acgccgccct gtatgatgca aaacgagcag gacggaatag agtggtctca     1020

gtggactaca aagatgatga cgacaag                                         1047


<210>  20
<211>  349
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  20

Met Leu Ala Cys Pro Leu Pro Pro Asp Ala Ala Leu Arg Gln Gln Ala 
1               5                   10                  15      


Leu Asp Asp Met Ala Leu Val Asp Thr Pro Ala Glu His Tyr Leu Asp 
            20                  25                  30          


Ala Leu Val Glu Leu Ala Arg Glu Thr Phe Gly Val Lys Thr Val Leu 
        35                  40                  45              


Ile Ser Leu Ile Asp His Asp Arg Gln Trp Phe Lys Ala Arg Ile Gly 
    50                  55                  60                  


Leu Asp Ala Glu Gln Thr Pro Arg Asp Leu Ser Phe Cys Gly His Ala 
65                  70                  75                  80  


Ile Leu Ala Ser Glu Pro Leu Met Val Thr Asp Ala Ser Arg Asp Pro 
                85                  90                  95      


Ala Phe His Ala Asn Pro Leu Val Thr Gly Pro Pro Phe Ile Arg Phe 
            100                 105                 110         


Tyr Ala Gly Glu Pro Leu His Ala Ser Asn Gly Gln Ala Ile Gly Thr 
        115                 120                 125             


Leu Cys Leu Ile Asp Pro Ser Pro Ala Leu Leu Ala Leu Arg Glu Gly 
    130                 135                 140                 


Arg Gln Leu Asn Arg Leu Ser Ile Leu Ala Glu Gly Tyr Leu Gln Leu 
145                 150                 155                 160 


Arg Ser Leu Thr Glu His Thr Arg Phe Leu Arg Gln Glu Ile Asp Arg 
                165                 170                 175     


Glu Gln Arg Lys Ser Leu Leu Asp Pro Leu Thr Gln Leu Trp Asn Arg 
            180                 185                 190         


Ala Gly Phe His Ala Leu His Gln His Glu Leu Glu Leu Ala Ala Ala 
        195                 200                 205             


Ser Ala Gln Arg Ile Gly Ile Ile Tyr Ser Asp Ile Asp His Phe Lys 
    210                 215                 220                 


Ala Ile Asn Ala Thr Leu Gly His Ala Ala Gly Ala Ser Val Leu Arg 
225                 230                 235                 240 


Glu Ala Ala Ser Arg Leu Arg Ala Ala Leu Ala Pro Glu Ala Leu Leu 
                245                 250                 255     


Ala Arg Phe Gly Gly Glu Glu Phe Val Ala Met Val Arg Val Arg Glu 
            260                 265                 270         


Thr Thr Glu Leu Thr Met Ile Ala Asn Arg Ile Arg Glu Leu Met Glu 
        275                 280                 285             


Ala Thr Pro Ile Asp Cys Ala Gly Thr Ser Val Pro Val Thr Ile Ser 
    290                 295                 300                 


Ala Gly Cys Thr Leu Ala Gly Ser Gly Glu Glu Pro Glu Arg Ala Leu 
305                 310                 315                 320 


Ala Arg Ala Asp Ala Ala Leu Tyr Asp Ala Lys Arg Ala Gly Arg Asn 
                325                 330                 335     


Arg Val Val Ser Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            340                 345                 


<210>  21
<211>  1065
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  21
atgcacaacc ctcacgaatc aaagaccgac ctgggggctc ctctggacgg ggctgtcatg       60

gtgctgctgg tggacgatca ggcaatgatt ggagaggccg tgcggagatc cctggcatct      120

gaggccggca tcgacttcca cttttgctct gatcctcagc aggcagtggc agtggcaaac      180

cagatcaagc caaccgtgat cctgcaggac ctggtcatgc ctggagtgga tggcctgacc      240

ctgctggcag catatagagg aaatcctgca acaagagaca tcccaatcat cgtgctgtct      300

accaaggagg agccaacagt gaaaagcgcc gccttcgccg caggagcaaa cgactacctg      360

gtgaagctgc ctgatgcaat tgaactggtg gcacggatca gataccactc tcggagctat      420

atcgccctgc agcagagaga tgaggcctat agggccctga gagagtctca gcagcagctg      480

ctggagacaa acctggtgct gcagcgcctg atgaattctg atggcctgac aggcctgtcc      540

aacaggcgcc actttgatga gtacctggag atggagtggc ggagatccct gagagagcag      600

tctcagctgt ccctgctgat gattgacgtg gattacttca agtcttataa tgacaccttt      660

ggccacgtgg ccggcgatga ggccctgaga caggtggcag gagcaatccg ggagggctgt      720

agcagaagct ctgacctggc agcaaggtac ggcggcgagg agtttgcaat ggtgctgcca      780

ggcacctccc ctggcggcgc caggctgctg gcagagaagg tgaggagaac agtggagtct      840

ctgcagatct ctcacgacca gcccagacct ggcagccacc tgaccgtgtc cattggcgtg      900

tctacactgg tgcctggcgg cggcggccag accttccggg tgctgattga gatggcagat      960

caggccctgt atcaggccaa gaacaatggc cgcaatcagg tgggcctgat ggagcagcca     1020

gtgccacccg ccccagcagg agactacaag gacgatgacg acaaa                     1065


<210>  22
<211>  355
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  22

Met His Asn Pro His Glu Ser Lys Thr Asp Leu Gly Ala Pro Leu Asp 
1               5                   10                  15      


Gly Ala Val Met Val Leu Leu Val Asp Asp Gln Ala Met Ile Gly Glu 
            20                  25                  30          


Ala Val Arg Arg Ser Leu Ala Ser Glu Ala Gly Ile Asp Phe His Phe 
        35                  40                  45              


Cys Ser Asp Pro Gln Gln Ala Val Ala Val Ala Asn Gln Ile Lys Pro 
    50                  55                  60                  


Thr Val Ile Leu Gln Asp Leu Val Met Pro Gly Val Asp Gly Leu Thr 
65                  70                  75                  80  


Leu Leu Ala Ala Tyr Arg Gly Asn Pro Ala Thr Arg Asp Ile Pro Ile 
                85                  90                  95      


Ile Val Leu Ser Thr Lys Glu Glu Pro Thr Val Lys Ser Ala Ala Phe 
            100                 105                 110         


Ala Ala Gly Ala Asn Asp Tyr Leu Val Lys Leu Pro Asp Ala Ile Glu 
        115                 120                 125             


Leu Val Ala Arg Ile Arg Tyr His Ser Arg Ser Tyr Ile Ala Leu Gln 
    130                 135                 140                 


Gln Arg Asp Glu Ala Tyr Arg Ala Leu Arg Glu Ser Gln Gln Gln Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Leu Val Leu Gln Arg Leu Met Asn Ser Asp Gly Leu 
                165                 170                 175     


Thr Gly Leu Ser Asn Arg Arg His Phe Asp Glu Tyr Leu Glu Met Glu 
            180                 185                 190         


Trp Arg Arg Ser Leu Arg Glu Gln Ser Gln Leu Ser Leu Leu Met Ile 
        195                 200                 205             


Asp Val Asp Tyr Phe Lys Ser Tyr Asn Asp Thr Phe Gly His Val Ala 
    210                 215                 220                 


Gly Asp Glu Ala Leu Arg Gln Val Ala Gly Ala Ile Arg Glu Gly Cys 
225                 230                 235                 240 


Ser Arg Ser Ser Asp Leu Ala Ala Arg Tyr Gly Gly Glu Glu Phe Ala 
                245                 250                 255     


Met Val Leu Pro Gly Thr Ser Pro Gly Gly Ala Arg Leu Leu Ala Glu 
            260                 265                 270         


Lys Val Arg Arg Thr Val Glu Ser Leu Gln Ile Ser His Asp Gln Pro 
        275                 280                 285             


Arg Pro Gly Ser His Leu Thr Val Ser Ile Gly Val Ser Thr Leu Val 
    290                 295                 300                 


Pro Gly Gly Gly Gly Gln Thr Phe Arg Val Leu Ile Glu Met Ala Asp 
305                 310                 315                 320 


Gln Ala Leu Tyr Gln Ala Lys Asn Asn Gly Arg Asn Gln Val Gly Leu 
                325                 330                 335     


Met Glu Gln Pro Val Pro Pro Ala Pro Ala Gly Asp Tyr Lys Asp Asp 
            340                 345                 350         


Asp Asp Lys 
        355 


<210>  23
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  viPA3702 (WspR, N-terminal 1-175 replaced with Saccharomyces 
       cerevisiae GCN4(249-278))

DNA sequence

<400>  23
agaatgaaac agctggagga caaggtggag gaactgctga gcaagaacta ccatctggag       60

aacgaagtgg caagactgaa aaaactggtg ctgacaggcc tgtctaaccg gagacacttt      120

gatgagtacc tggagatgga gtggaggcgc agcctgagag agcagtctca gctgagcctg      180

ctgatgatcg acgtggatta cttcaagagc tataatgaca catttggcca cgtggccggc      240

gatgaggccc tgaggcaggt ggccggcgcc atcagggagg gctgctcccg cagctccgat      300

ctggccgccc gctatggcgg cgaggagttc gccatggtgc tgccaggcac ctctcctggc      360

ggcgccagac tgctggcaga gaaggtgcgg agaacagtgg agtccctgca gatctctcac      420

gaccagcccc ggcctggctc ccacctgacc gtgagcatcg gcgtgtccac actggtgcct      480

ggcggcggcg gccagacctt tcgggtgctg attgagatgg cagatcaggc cctgtaccag      540

gccaagaaca atggcagaaa ccaggtgggc ctgatggaac agccagtgcc accagcccca      600

gcaggagact acaaggacga cgatgacaaa                                       630


<210>  24
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PA3702 (WspR, N-terminal 1-175 replaced with Saccharomyces 
       cerevisiae GCN4(249-278))

Protein

<400>  24

Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Leu Thr 
            20                  25                  30          


Gly Leu Ser Asn Arg Arg His Phe Asp Glu Tyr Leu Glu Met Glu Trp 
        35                  40                  45              


Arg Arg Ser Leu Arg Glu Gln Ser Gln Leu Ser Leu Leu Met Ile Asp 
    50                  55                  60                  


Val Asp Tyr Phe Lys Ser Tyr Asn Asp Thr Phe Gly His Val Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Leu Arg Gln Val Ala Gly Ala Ile Arg Glu Gly Cys Ser 
                85                  90                  95      


Arg Ser Ser Asp Leu Ala Ala Arg Tyr Gly Gly Glu Glu Phe Ala Met 
            100                 105                 110         


Val Leu Pro Gly Thr Ser Pro Gly Gly Ala Arg Leu Leu Ala Glu Lys 
        115                 120                 125             


Val Arg Arg Thr Val Glu Ser Leu Gln Ile Ser His Asp Gln Pro Arg 
    130                 135                 140                 


Pro Gly Ser His Leu Thr Val Ser Ile Gly Val Ser Thr Leu Val Pro 
145                 150                 155                 160 


Gly Gly Gly Gly Gln Thr Phe Arg Val Leu Ile Glu Met Ala Asp Gln 
                165                 170                 175     


Ala Leu Tyr Gln Ala Lys Asn Asn Gly Arg Asn Gln Val Gly Leu Met 
            180                 185                 190         


Glu Gln Pro Val Pro Pro Ala Pro Ala Gly Asp Tyr Lys Asp Asp Asp 
        195                 200                 205             


Asp Lys 
    210 


<210>  25
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PA3702 (WspR, N-terminal 1-175 replaced with human albumin 
       preproprotein signal peptide and Saccharomyces cerevisiae 
       GCN4(249-278)) DNA sequence

<400>  25
atgaagtggg tgacctttat cagtctgctg tttctgttct caagcgcata tagtaggatg       60

aagcagctgg aggacaaagt ggaggaactg ctgagcaaga actaccacct ggagaatgag      120

gtggcaagac tgaagaagct ggtgctgaca ggcctgtcta accggagaca ctttgacgag      180

tatctggaga tggagtggag gcgcagcctg agggagcagt ctcagctgag cctgctgatg      240

atcgacgtgg attacttcaa gtcctataat gacacatttg gccacgtggc cggcgatgag      300

gccctgaggc aggtggccgg cgccatcagg gagggctgct cccgcagctc cgatctggcc      360

gcccgctacg gcggcgagga gttcgccatg gtgctgccag gcacctctcc tggcggcgcc      420

agactgctgg cagagaaggt gcggagaaca gtggagtccc tgcagatctc tcacgaccag      480

ccccggcctg gctctcacct gaccgtgagc attggcgtgt ccacactggt gcctggcggc      540

ggcggccaga cctttcgggt gctgattgag atggcagatc aggccctgta tcaggccaag      600

aacaatggca gaaaccaggt gggcctgatg gaacagccag tgcccccagc cccagcagga      660

gattacaaag atgacgacga taaa                                             684


<210>  26
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PA3702 (WspR, N-terminal 1-175 replaced with human albumin 
       preproprotein signal peptide and Saccharomyces cerevisiae 
       GCN4(249-278)) protein

<400>  26

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser 
            20                  25                  30          


Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val 
        35                  40                  45              


Leu Thr Gly Leu Ser Asn Arg Arg His Phe Asp Glu Tyr Leu Glu Met 
    50                  55                  60                  


Glu Trp Arg Arg Ser Leu Arg Glu Gln Ser Gln Leu Ser Leu Leu Met 
65                  70                  75                  80  


Ile Asp Val Asp Tyr Phe Lys Ser Tyr Asn Asp Thr Phe Gly His Val 
                85                  90                  95      


Ala Gly Asp Glu Ala Leu Arg Gln Val Ala Gly Ala Ile Arg Glu Gly 
            100                 105                 110         


Cys Ser Arg Ser Ser Asp Leu Ala Ala Arg Tyr Gly Gly Glu Glu Phe 
        115                 120                 125             


Ala Met Val Leu Pro Gly Thr Ser Pro Gly Gly Ala Arg Leu Leu Ala 
    130                 135                 140                 


Glu Lys Val Arg Arg Thr Val Glu Ser Leu Gln Ile Ser His Asp Gln 
145                 150                 155                 160 


Pro Arg Pro Gly Ser His Leu Thr Val Ser Ile Gly Val Ser Thr Leu 
                165                 170                 175     


Val Pro Gly Gly Gly Gly Gln Thr Phe Arg Val Leu Ile Glu Met Ala 
            180                 185                 190         


Asp Gln Ala Leu Tyr Gln Ala Lys Asn Asn Gly Arg Asn Gln Val Gly 
        195                 200                 205             


Leu Met Glu Gln Pro Val Pro Pro Ala Pro Ala Gly Asp Tyr Lys Asp 
    210                 215                 220                 


Asp Asp Asp Lys 
225             


<210>  27
<211>  912
<212>  DNA
<213>  Escherichia coli

<400>  27
atgatcaaga agactaccga gattgacgct atcctgctga acctgaataa ggctatcgac       60

gcacattacc agtggctggt gtccatgttc cactctgtgg tggcaaggga tgcatccaag      120

cctgagatca ccgataacca ctcctacggc ctgtgccagt ttggccggtg gattgaccac      180

ctgcggcccc tggacaatga tgagctgcct tatgtgcggc tgatggattc tgcccaccag      240

cacatgcaca actgtgggag ggagctgatg ctggcaattg tggagaatca ctggcaggat      300

gcacactttg atgcatttca ggagggcgtg ctgtccttca ccgccgccct gacagactac      360

aagatctatc tgctgaccat ccggtctaac atggatgtgc tgacaggcct gccaggccgg      420

agagtgctgg acgagagctt cgatcaccag ctgaggaaca cagagcccct gaatctgtac      480

ctgatgctgc tggacatcga tcgctttaag ctggtgaatg acacatatgg acacctgatt      540

ggcgatgtgg tgctgagaac cctggcaaca tacctggcat cctggaccag ggactatgag      600

acagtgtaca gatatggcgg cgaggagttc atcatcatcg tgaaggccgc caatgatgag      660

gaggcctgca gggcaggcgt gcgcatctgt cagctggtgg ataatcacgc aatcacccac      720

tctgagggac acatcaatat caccgtgaca gcaggcgtga gcagggcatt ccctgaagag      780

acactggacg tggtcatcgg aagagccgat agagcaatgt atgagggcaa gcagacagga      840

aggaatcgct gcatgtttat tgacgagcag aatgtgatta accgggtgga ctacaaagac      900

gacgatgaca ag                                                          912


<210>  28
<211>  304
<212>  PRT
<213>  Escherichia coli

<400>  28

Met Ile Lys Lys Thr Thr Glu Ile Asp Ala Ile Leu Leu Asn Leu Asn 
1               5                   10                  15      


Lys Ala Ile Asp Ala His Tyr Gln Trp Leu Val Ser Met Phe His Ser 
            20                  25                  30          


Val Val Ala Arg Asp Ala Ser Lys Pro Glu Ile Thr Asp Asn His Ser 
        35                  40                  45              


Tyr Gly Leu Cys Gln Phe Gly Arg Trp Ile Asp His Leu Arg Pro Leu 
    50                  55                  60                  


Asp Asn Asp Glu Leu Pro Tyr Val Arg Leu Met Asp Ser Ala His Gln 
65                  70                  75                  80  


His Met His Asn Cys Gly Arg Glu Leu Met Leu Ala Ile Val Glu Asn 
                85                  90                  95      


His Trp Gln Asp Ala His Phe Asp Ala Phe Gln Glu Gly Val Leu Ser 
            100                 105                 110         


Phe Thr Ala Ala Leu Thr Asp Tyr Lys Ile Tyr Leu Leu Thr Ile Arg 
        115                 120                 125             


Ser Asn Met Asp Val Leu Thr Gly Leu Pro Gly Arg Arg Val Leu Asp 
    130                 135                 140                 


Glu Ser Phe Asp His Gln Leu Arg Asn Thr Glu Pro Leu Asn Leu Tyr 
145                 150                 155                 160 


Leu Met Leu Leu Asp Ile Asp Arg Phe Lys Leu Val Asn Asp Thr Tyr 
                165                 170                 175     


Gly His Leu Ile Gly Asp Val Val Leu Arg Thr Leu Ala Thr Tyr Leu 
            180                 185                 190         


Ala Ser Trp Thr Arg Asp Tyr Glu Thr Val Tyr Arg Tyr Gly Gly Glu 
        195                 200                 205             


Glu Phe Ile Ile Ile Val Lys Ala Ala Asn Asp Glu Glu Ala Cys Arg 
    210                 215                 220                 


Ala Gly Val Arg Ile Cys Gln Leu Val Asp Asn His Ala Ile Thr His 
225                 230                 235                 240 


Ser Glu Gly His Ile Asn Ile Thr Val Thr Ala Gly Val Ser Arg Ala 
                245                 250                 255     


Phe Pro Glu Glu Thr Leu Asp Val Val Ile Gly Arg Ala Asp Arg Ala 
            260                 265                 270         


Met Tyr Glu Gly Lys Gln Thr Gly Arg Asn Arg Cys Met Phe Ile Asp 
        275                 280                 285             


Glu Gln Asn Val Ile Asn Arg Val Asp Tyr Lys Asp Asp Asp Asp Lys 
    290                 295                 300                 


<210>  29
<211>  912
<212>  DNA
<213>  Escherichia coli

<400>  29
atgattaaga aaacaacaga gattgacgct atcctgctga acctgaacaa ggctatcgac       60

gcacattacc agtggctggt gtctatgttc cactctgtgg tggcaagaga tgcatccaag      120

cctgagatca ccgataacca ctcctacggc ctgtgccagt ttggagcatg gattgcacac      180

ctggcccctc tggccaatga tgaactgcct tatgtggccc tgatggcatc tgcccaccag      240

cacatgcaca actgtggaag ggagctgatg ctggcaattg tggagaatca ctggcaggat      300

gcacactttg atgcatttca ggagggcgtg ctgtccttca ccgccgccct gacagactac      360

aagatctatc tgctgaccat ccggtctaat atggatgtgc tgacaggcct gccaggaaga      420

gccgtgctgg cagagagctt cgaccaccag ctgaggaaca cagagcccct gaatctgtac      480

ctgatgctgc tggacatcga tcgctttaag ctggtgaatg acacatatgg ccacctgatt      540

ggcgatgtgg tgctgcggac cctggcaaca tacctggcct cctggaccag ggattatgag      600

acagtgtaca gatatggcgg cgaggagttc atcatcatcg tgaaagcagc aaatgatgag      660

gaggcctgca gagccggcgt gagaatctgt cagctggtgg ataatcacgc aatcacccac      720

tctgagggac acatcaatat caccgtgaca gcaggcgtga gcagagcatt tcctgaggag      780

acactggacg tggtcatcgg aagggcagat agagcaatgt atgagggcaa gcagacagga      840

cggaatagat gcatgtttat tgacgagcag aatgtgatta accgggtgga ttacaaagac      900

gacgacgaca aa                                                          912


<210>  30
<211>  304
<212>  PRT
<213>  Escherichia coli

<400>  30

Met Ile Lys Lys Thr Thr Glu Ile Asp Ala Ile Leu Leu Asn Leu Asn 
1               5                   10                  15      


Lys Ala Ile Asp Ala His Tyr Gln Trp Leu Val Ser Met Phe His Ser 
            20                  25                  30          


Val Val Ala Arg Asp Ala Ser Lys Pro Glu Ile Thr Asp Asn His Ser 
        35                  40                  45              


Tyr Gly Leu Cys Gln Phe Gly Ala Trp Ile Ala His Leu Ala Pro Leu 
    50                  55                  60                  


Ala Asn Asp Glu Leu Pro Tyr Val Ala Leu Met Ala Ser Ala His Gln 
65                  70                  75                  80  


His Met His Asn Cys Gly Arg Glu Leu Met Leu Ala Ile Val Glu Asn 
                85                  90                  95      


His Trp Gln Asp Ala His Phe Asp Ala Phe Gln Glu Gly Val Leu Ser 
            100                 105                 110         


Phe Thr Ala Ala Leu Thr Asp Tyr Lys Ile Tyr Leu Leu Thr Ile Arg 
        115                 120                 125             


Ser Asn Met Asp Val Leu Thr Gly Leu Pro Gly Arg Ala Val Leu Ala 
    130                 135                 140                 


Glu Ser Phe Asp His Gln Leu Arg Asn Thr Glu Pro Leu Asn Leu Tyr 
145                 150                 155                 160 


Leu Met Leu Leu Asp Ile Asp Arg Phe Lys Leu Val Asn Asp Thr Tyr 
                165                 170                 175     


Gly His Leu Ile Gly Asp Val Val Leu Arg Thr Leu Ala Thr Tyr Leu 
            180                 185                 190         


Ala Ser Trp Thr Arg Asp Tyr Glu Thr Val Tyr Arg Tyr Gly Gly Glu 
        195                 200                 205             


Glu Phe Ile Ile Ile Val Lys Ala Ala Asn Asp Glu Glu Ala Cys Arg 
    210                 215                 220                 


Ala Gly Val Arg Ile Cys Gln Leu Val Asp Asn His Ala Ile Thr His 
225                 230                 235                 240 


Ser Glu Gly His Ile Asn Ile Thr Val Thr Ala Gly Val Ser Arg Ala 
                245                 250                 255     


Phe Pro Glu Glu Thr Leu Asp Val Val Ile Gly Arg Ala Asp Arg Ala 
            260                 265                 270         


Met Tyr Glu Gly Lys Gln Thr Gly Arg Asn Arg Cys Met Phe Ile Asp 
        275                 280                 285             


Glu Gln Asn Val Ile Asn Arg Val Asp Tyr Lys Asp Asp Asp Asp Lys 
    290                 295                 300                 


<210>  31
<211>  843
<212>  DNA
<213>  Listeria monocytogenes

<400>  31
atggacttca gcaacatgag catcctgcac tatctggcta atatcgtgga cattctggtc       60

gtctggttcg tgatctacaa ggtcatcatg ctgatcagag gaacaaaggc agtgcagctg      120

ctgaagggca tcttcatcat cattgcagtg aagctgctgt ctggcttctt tggcctgcag      180

acagtggagt ggatcacaga tcagatgctg acctggggct tcctggcaat catcatcatc      240

tttcagcctg agctgagaag agccctggag acactgggaa gaggcaacat ctttaccaga      300

tatggcagca ggattgagag agagcagcac cacctgatcg agagcatcga gaagtccacc      360

cagtatatgg ccaaaagaag aattggcgcc ctgatttctg tggcaaggga tacaggaatg      420

gacgattaca tcgagacagg catcccactg aacgccaaga tcagctccca gctgctgatc      480

aacatcttca tccctaatac acctctgcac gatggagccg tgatcatcaa gggaaatgag      540

attgcatccg ccgcatctta tctgccactg tctgattctc cctttctgtc taaggaactg      600

ggaaccagac acagagccgc cctgggcatc tctgaggtga ccgacagcat taccattgtg      660

gtgtccgagg agacaggcgg catctctctg accaagggcg gcgagctgtt ccgcgacgtg      720

agcgaggagg agctgcacaa gatcctgctg aaggagctgg tgacagtgac agccaagaag      780

cccagcattt tctcaaagtg gaagggcggg aagagcgagg actacaaaga cgatgatgat      840

aag                                                                    843


<210>  32
<211>  281
<212>  PRT
<213>  Listeria monocytogenes

<400>  32

Met Asp Phe Ser Asn Met Ser Ile Leu His Tyr Leu Ala Asn Ile Val 
1               5                   10                  15      


Asp Ile Leu Val Val Trp Phe Val Ile Tyr Lys Val Ile Met Leu Ile 
            20                  25                  30          


Arg Gly Thr Lys Ala Val Gln Leu Leu Lys Gly Ile Phe Ile Ile Ile 
        35                  40                  45              


Ala Val Lys Leu Leu Ser Gly Phe Phe Gly Leu Gln Thr Val Glu Trp 
    50                  55                  60                  


Ile Thr Asp Gln Met Leu Thr Trp Gly Phe Leu Ala Ile Ile Ile Ile 
65                  70                  75                  80  


Phe Gln Pro Glu Leu Arg Arg Ala Leu Glu Thr Leu Gly Arg Gly Asn 
                85                  90                  95      


Ile Phe Thr Arg Tyr Gly Ser Arg Ile Glu Arg Glu Gln His His Leu 
            100                 105                 110         


Ile Glu Ser Ile Glu Lys Ser Thr Gln Tyr Met Ala Lys Arg Arg Ile 
        115                 120                 125             


Gly Ala Leu Ile Ser Val Ala Arg Asp Thr Gly Met Asp Asp Tyr Ile 
    130                 135                 140                 


Glu Thr Gly Ile Pro Leu Asn Ala Lys Ile Ser Ser Gln Leu Leu Ile 
145                 150                 155                 160 


Asn Ile Phe Ile Pro Asn Thr Pro Leu His Asp Gly Ala Val Ile Ile 
                165                 170                 175     


Lys Gly Asn Glu Ile Ala Ser Ala Ala Ser Tyr Leu Pro Leu Ser Asp 
            180                 185                 190         


Ser Pro Phe Leu Ser Lys Glu Leu Gly Thr Arg His Arg Ala Ala Leu 
        195                 200                 205             


Gly Ile Ser Glu Val Thr Asp Ser Ile Thr Ile Val Val Ser Glu Glu 
    210                 215                 220                 


Thr Gly Gly Ile Ser Leu Thr Lys Gly Gly Glu Leu Phe Arg Asp Val 
225                 230                 235                 240 


Ser Glu Glu Glu Leu His Lys Ile Leu Leu Lys Glu Leu Val Thr Val 
                245                 250                 255     


Thr Ala Lys Lys Pro Ser Ile Phe Ser Lys Trp Lys Gly Gly Lys Ser 
            260                 265                 270         


Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
        275                 280     


<210>  33
<211>  603
<212>  DNA
<213>  Listeria monocytogenes

<400>  33
tttcagcccg aactgcggag agcactggag accctgggga gaggaaatat cttcactcgc       60

tatgggagcc ggattgagag agaacagcac cacctgatcg agagcatcga gaagtccacc      120

cagtacatgg caaagagaag aattggcgcc ctgatctctg tggcaagaga caccggcatg      180

gacgattata tcgagacagg catccctctg aacgccaaga tcagctccca gctgctgatc      240

aacatcttca tccctaatac ccctctgcac gatggagccg tgatcatcaa gggaaatgag      300

attgcatccg ccgcatctta cctgccactg tctgatagcc cctttctgag caaggaactg      360

ggaacaaggc acagagccgc cctgggcatc tctgaggtga ccgacagcat taccattgtg      420

gtgtccgagg agacaggcgg catctctctg acaaagggcg gcgagctgtt cagggacgtg      480

agcgaggagg agctgcacaa gatcctgctg aaggagctgg tgacagtgac agccaagaag      540

ccctcaatct tcagcaagtg gaaaggaggg aaaagcgagg actacaagga cgacgacgat      600

aag                                                                    603


<210>  34
<211>  201
<212>  PRT
<213>  Listeria monocytogenes

<400>  34

Phe Gln Pro Glu Leu Arg Arg Ala Leu Glu Thr Leu Gly Arg Gly Asn 
1               5                   10                  15      


Ile Phe Thr Arg Tyr Gly Ser Arg Ile Glu Arg Glu Gln His His Leu 
            20                  25                  30          


Ile Glu Ser Ile Glu Lys Ser Thr Gln Tyr Met Ala Lys Arg Arg Ile 
        35                  40                  45              


Gly Ala Leu Ile Ser Val Ala Arg Asp Thr Gly Met Asp Asp Tyr Ile 
    50                  55                  60                  


Glu Thr Gly Ile Pro Leu Asn Ala Lys Ile Ser Ser Gln Leu Leu Ile 
65                  70                  75                  80  


Asn Ile Phe Ile Pro Asn Thr Pro Leu His Asp Gly Ala Val Ile Ile 
                85                  90                  95      


Lys Gly Asn Glu Ile Ala Ser Ala Ala Ser Tyr Leu Pro Leu Ser Asp 
            100                 105                 110         


Ser Pro Phe Leu Ser Lys Glu Leu Gly Thr Arg His Arg Ala Ala Leu 
        115                 120                 125             


Gly Ile Ser Glu Val Thr Asp Ser Ile Thr Ile Val Val Ser Glu Glu 
    130                 135                 140                 


Thr Gly Gly Ile Ser Leu Thr Lys Gly Gly Glu Leu Phe Arg Asp Val 
145                 150                 155                 160 


Ser Glu Glu Glu Leu His Lys Ile Leu Leu Lys Glu Leu Val Thr Val 
                165                 170                 175     


Thr Ala Lys Lys Pro Ser Ile Phe Ser Lys Trp Lys Gly Gly Lys Ser 
            180                 185                 190         


Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
        195                 200     


