                         SEQUENCE LISTING

<110>  Arizona Board of Regents on Behalf of the University of 
       Arizona
 
<120>  INHIBITORS OF SARS-CoV-2 VIRAL REPLICATION AND USES THEREOF

<130>  UAZ-39507.601

<150>  US 63/194,473
<151>  2021-05-28

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  1

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Thr Val Tyr Cys Pro Arg His Val Ile Cys Thr Ala Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Ser Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Leu Leu Arg Leu Lys Val Asp Thr Ser Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn His Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr His His His Met Glu Leu Phe Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Glu Gly Lys Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Leu Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ala Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Thr Ile Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  2
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  2

Ser Gly Leu Val Lys Met Ser His Pro Ser Gly Asp Val Glu Ala Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Ser Met Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asn Thr Val Trp Cys Pro Arg His Val Met Cys Pro Ala Asp Gln 
        35                  40                  45              


Leu Ser Asp Pro Asn Tyr Asp Ala Leu Leu Ile Ser His Thr Asn His 
    50                  55                  60                  


Ser Pro Ser Val Gln Lys His Ile Gly Ala Pro Ala Asn Leu Arg Val 
65                  70                  75                  80  


Val Gly His Ala Met Gln Gly Thr Leu Leu Lys Leu Thr Val Asp Val 
                85                  90                  95      


Ala Asn Pro Ser Thr Pro Ala Tyr Thr Phe Thr Thr Val Lys Pro Gly 
            100                 105                 110         


Ala Ala Pro Ser Val Leu Ala Cys Tyr Asn Gly Arg Pro Thr Gly Thr 
        115                 120                 125             


Phe Thr Val Val His Arg Pro Asn Tyr Thr Ile Lys Gly Ser Phe Leu 
    130                 135                 140                 


Cys Gly Ser Cys Gly Ser Val Gly Tyr Thr Lys Glu Gly Ser Val Ile 
145                 150                 155                 160 


Asn Phe Cys Tyr His His Gln Met Glu Leu Ala Asn Gly Thr His Thr 
                165                 170                 175     


Gly Ser Ala Phe Asp Gly Thr Met Tyr Gly Ala Phe His Asp Lys Gln 
            180                 185                 190         


Val His Gln Val Gln Leu Thr Asp Lys Tyr Cys Ser Val Asn Val Val 
        195                 200                 205             


Ala Trp Leu Tyr Ala Ala Ile Leu Asn Gly Cys Ala Trp Phe Val Lys 
    210                 215                 220                 


Pro Asn Arg Thr Ser Val Val Ser Phe Asn Glu Trp Ala Leu Ala Asn 
225                 230                 235                 240 


Gln Pro Thr Glu Phe Val Gly Thr Gln Ser Val Asp His Leu Ala Val 
                245                 250                 255     


Lys Thr Gly Val Ala Ile Glu Gln Leu Leu Tyr Ala Ile Gln Gln Leu 
            260                 265                 270         


Tyr Thr Gly Phe Gln Gly Lys Gln Ile Leu Gly Ser Thr Met Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Glu Asp Val Asn His Gln Ile Met Gly Val Val 
    290                 295                 300                 


His Gln 
305     


<210>  3
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  3

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  4
<211>  302
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  4

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Asp Thr Ala Asn Pro Lys Thr Pro Lys 
                85                  90                  95      


Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro Ser Val Leu Ala 
            100                 105                 110         


Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala Met Arg Pro 
        115                 120                 125             


Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys Gly Ser Val 
    130                 135                 140                 


Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys Tyr Met His His 
145                 150                 155                 160 


Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp Leu Asx Gly Asn 
                165                 170                 175     


Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln Ala Ala Gly Thr 
            180                 185                 190         


Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu Tyr Ala Ala Val 
        195                 200                 205             


Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr Thr Thr Leu Asn 
    210                 215                 220                 


Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr Gln 
225                 230                 235                 240 


Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala 
                245                 250                 255     


Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly His 
            260                 265                 270         


Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr 
        275                 280                 285             


Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln 
    290                 295                 300         


<210>  5
<211>  302
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  5

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Asp Thr Ala Asn Pro Lys Thr Pro Lys 
                85                  90                  95      


Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro Ser Val Leu Ala 
            100                 105                 110         


Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala Met Arg Pro 
        115                 120                 125             


Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys Gly Ser Val 
    130                 135                 140                 


Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys Tyr Met His His 
145                 150                 155                 160 


Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp Leu Asx Gly Asn 
                165                 170                 175     


Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln Ala Ala Gly Thr 
            180                 185                 190         


Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu Tyr Ala Ala Val 
        195                 200                 205             


Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr Thr Thr Leu Asn 
    210                 215                 220                 


Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr Gln 
225                 230                 235                 240 


Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala 
                245                 250                 255     


Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly His 
            260                 265                 270         


Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr 
        275                 280                 285             


Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln 
    290                 295                 300         


<210>  6
<211>  304
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  6

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Asp Thr Ala Asn Pro Lys Thr 
                85                  90                  95      


Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro Ser Val 
            100                 105                 110         


Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala Met 
        115                 120                 125             


Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys Gly 
    130                 135                 140                 


Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys Tyr His 
145                 150                 155                 160 


His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp Leu Glu 
                165                 170                 175     


Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln Ala Ala 
            180                 185                 190         


Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu Tyr Ala 
        195                 200                 205             


Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr Thr Thr 
    210                 215                 220                 


Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu 
225                 230                 235                 240 


Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly 
                245                 250                 255     


Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln Asn 
            260                 265                 270         


Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu 
        275                 280                 285             


Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln 
    290                 295                 300                 


<210>  7
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  7

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Asx Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Phe Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Asx Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  8
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  8

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Asx Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  9
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  9

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Asx Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  10
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  10

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Asx Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  11
<211>  305
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  11

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu Asp 
            20                  25                  30          


Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp Met 
        35                  40                  45              


Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His Asn 
    50                  55                  60                  


Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His Ser 
65                  70                  75                  80  


Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro Lys 
                85                  90                  95      


Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro Ser 
            100                 105                 110         


Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys Ala 
        115                 120                 125             


Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser Cys 
    130                 135                 140                 


Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys Tyr 
145                 150                 155                 160 


His His His Met Glu Leu Phe Thr Gly Val His Ala Gly Thr Asp Leu 
                165                 170                 175     


Asx Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln Ala 
            180                 185                 190         


Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu Tyr 
        195                 200                 205             


Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr Thr 
    210                 215                 220                 


Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro 
225                 230                 235                 240 


Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr 
                245                 250                 255     


Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln 
            260                 265                 270         


Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp 
        275                 280                 285             


Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe 
    290                 295                 300                 


Gln 
305 


<210>  12
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  12

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Phe Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Asx Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  13
<211>  304
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  13

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Phe Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Asx Gly Asn Phe Tyr Gly Pro Pro Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Trp Val Leu Tyr Ala 
        195                 200                 205             


Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr Thr Thr 
    210                 215                 220                 


Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu 
225                 230                 235                 240 


Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly 
                245                 250                 255     


Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln Asn 
            260                 265                 270         


Gly His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu 
        275                 280                 285             


Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln 
    290                 295                 300                 


<210>  14
<211>  303
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  14

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Pro Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr His His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Asx Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Trp Leu Tyr Ala Ala 
        195                 200                 205             


Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr Thr Thr Leu 
    210                 215                 220                 


Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr 
225                 230                 235                 240 


Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly Ile 
                245                 250                 255     


Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly 
            260                 265                 270         


His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe 
        275                 280                 285             


Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln 
    290                 295                 300             


<210>  15
<211>  303
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic

<400>  15

Ser Gly Pro Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Pro Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Pro 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg His Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Trp Leu Tyr Ala Ala 
        195                 200                 205             


Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Pro Thr Thr Thr Leu 
    210                 215                 220                 


Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr 
225                 230                 235                 240 


Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln Thr Gly Ile 
                245                 250                 255     


Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly 
            260                 265                 270         


His Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe 
        275                 280                 285             


Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr Phe Gln 
    290                 295                 300             


