                               SEQUENCE LISTING

<110> MERCK SHARP & DOHME LLC
 
<120> TRANSAMINASE ENZYMES FOR THE TRANSAMINATION OF (1 
      S,5R)-6,8-DIOXABICYCLO[3.2.1]OCTAN-4-ONE

<130> 25246-WO-PCT

<140>
<141>

<150> 63/194,298
<151> 2021-05-28

<150> 63/339,210
<151> 2022-05-06

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Ala Phe Ser Ala Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 2
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Ile Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Ile Val Trp Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp Phe Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 3
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Val Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Trp Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Arg 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 4
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Val Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Val Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Trp Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ser 
            180                 185                 190         


Ile Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Met Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 5
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Val Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Ala Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Trp Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ser 
            180                 185                 190         


Ile Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Glu 
                245                 250                 255     


Ser Leu Gly His Glu Ala Met Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 6
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Val 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Val Phe Asp Gln Gly Phe Tyr Ala Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Ala Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Gly Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ser 
            180                 185                 190         


Ile Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Arg 
                245                 250                 255     


Ser Leu Gly His Glu Ala Met Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 7
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Val 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Val Phe Asp Gln Gly Phe Tyr Ala Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Ala Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Trp Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Gly Val Val Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Ile Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ser 
            180                 185                 190         


Ile Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Arg 
                245                 250                 255     


Ser Leu Gly His Glu Ala Met Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 8
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Ala Phe Ser Leu Asp Thr Pro Glu Ile Val Tyr Thr His Asp Thr 
1               5                   10                  15      


Gly Leu Asp Tyr Ile Thr Tyr Ser Asp Tyr Glu Leu Asp Pro Ala Asn 
            20                  25                  30          


Pro Leu Ala Gly Gly Ala Ala Trp Ile Glu Gly Ala Phe Val Pro Pro 
        35                  40                  45              


Ser Glu Ala Arg Ile Ser Val Phe Asp Gln Gly Phe Tyr Thr Ser Asp 
    50                  55                  60                  


Ala Thr Tyr Thr Ala Phe His Val Trp Asn Gly Asn Ala Phe Arg Leu 
65                  70                  75                  80  


Gly Asp His Ile Glu Arg Leu Phe Ser Asn Ala Glu Ser Ile Arg Leu 
                85                  90                  95      


Ile Pro Pro Leu Thr Gln Asp Glu Val Lys Glu Ile Ala Leu Glu Leu 
            100                 105                 110         


Val Ala Lys Thr Glu Leu Arg Glu Ala Met Val Trp Val Ala Ile Thr 
        115                 120                 125             


Arg Gly Tyr Ser Ser Thr Pro Leu Glu Arg Asp Val Thr Lys His Arg 
    130                 135                 140                 


Pro Gln Val Tyr Met Tyr Ala Val Pro Tyr Gln Trp Ile Val Pro Phe 
145                 150                 155                 160 


Asp Arg Ile Arg Asp Gly Val His Leu Met Val Ala Gln Ser Val Arg 
                165                 170                 175     


Arg Thr Pro Arg Ser Ser Ile Asp Pro Gln Val Lys Asn Phe Ala Ala 
            180                 185                 190         


Gly Asp Leu Ile Arg Ala Ile Gln Glu Thr His Asp Arg Gly Phe Glu 
        195                 200                 205             


Leu Pro Leu Leu Leu Asp His Asp Asn Leu Leu Ala Glu Gly Pro Gly 
    210                 215                 220                 


Phe Asn Val Val Val Ile Lys Asp Gly Val Val Arg Ser Pro Gly Arg 
225                 230                 235                 240 


Ala Ala Leu Pro Gly Ile Thr Arg Lys Thr Val Leu Glu Ile Ala Arg 
                245                 250                 255     


Ser Leu Gly His Glu Ala Ile Leu Ala Asp Ile Thr Pro Ala Glu Leu 
            260                 265                 270         


Arg Asp Ala Asp Glu Val Leu Gly Cys Ser Thr Ala Gly Gly Val Trp 
        275                 280                 285             


Pro Phe Val Ser Val Asp Gly Asn Ser Ile Ser Asp Gly Val Pro Gly 
    290                 295                 300                 


Pro Val Thr Gln Ser Ile Ile Arg Arg Tyr Trp Glu Leu Asn Val Glu 
305                 310                 315                 320 


Pro Ser Cys Leu Leu Thr Pro Val Gln Tyr 
                325                 330 


<210> 9
<211> 993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atggcgttct cagcggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac taa                                   993


<210> 10
<211> 993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atggcgttct cactggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctatcttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgattgttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcggcaggtg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg actttgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgaatc tctgggtcac      780

gaagctatcc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac taa                                   993


<210> 11
<211> 990
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atggcgttct cactggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctgttttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgatggttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcggcgggcg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg accacgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctcgttc tctgggtcac      780

gaagctattc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac                                       990


<210> 12
<211> 990
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atggcgttct cactggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctgttttcga ccagggtttt      180

tatacttctg acgctaccta caccgtcttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgatggttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctgtgccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcgtcgattg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg accacgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgagtc tctgggtcac      780

gaagctatgc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac                                       990


<210> 13
<211> 993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atggcgttct cactggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctgttttcga ccagggtttt      180

tatacttctg acgctaccta caccgctttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgatggttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctgtgccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcgtcgattg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg accacgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctgagtc tctgggtcac      780

gaagctatgc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac taa                                   993


<210> 14
<211> 993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
atggcgttct cactggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc ggtctctgaa gctcgtatct ctgttttcga ccagggtttt      180

tatgcctctg acgctaccta caccgctttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgatggttg gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctgtcccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcgtcgattg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg accacgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctcgttc tctgggtcat      780

gaagctatgc tggctgacat caccccagct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac taa                                   993


<210> 15
<211> 993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atggcgttct cactggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc ggtctctgaa gctcgtatct ctgttttcga ccagggtttt      180

tatgcctctg acgctaccta caccgctttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gtggtctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgatggttg gggttgtaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctattccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcgtcgattg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg accacgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctcgttc tctgggtcat      780

gaagctatgc tggctgacat caccccagct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc gatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac taa                                   993


<210> 16
<211> 993
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
atggcgttct cactggacac ccctgaaatc gtttacaccc acgacaccgg tctggactat       60

atcacctact ctgactacga actggacccg gctaacccgc tggctggtgg tgccgcttgg      120

atcgaaggtg ctttcgttcc gccgtctgaa gctcgtatct ctgttttcga ccagggtttt      180

tatacttctg acgctaccta caccgctttc cacgtttgga acggtaacgc tttccgtctg      240

ggggaccaca tcgaacgtct gttctctaat gcggaatcta ttcgtttgat cccgccgctg      300

acccaggacg aagttaaaga gatcgctctg gaactggttg ctaaaaccga attgcgtgaa      360

gcgatggttt gggttgcaat cacccgtggt tactcttcta ccccattgga gcgtgacgtc      420

accaaacatc gtccgcaggt ttacatgtat gctgttccgt accagtggat cgtaccgttt      480

gaccgcatcc gtgacggtgt tcacctgatg gttgctcagt cagttcgtcg tacaccgcgt      540

agctctatcg acccgcaggt taaaaacttc gcggcgggcg acctgatccg tgcaattcag      600

gaaacccacg accgtggttt cgagttaccg ctgctgctgg accacgacaa cctgctggct      660

gaaggtccgg gtttcaacgt tgttgttatc aaagacggtg ttgttcgttc tccgggtcgt      720

gctgctctgc cgggtatcac ccgtaaaacc gttctggaaa tcgctcgttc tctgggtcac      780

gaagctattc tggctgacat caccccggct gaactgcgtg atgccgacga agttctgggt      840

tgctcaaccg cgggtggtgt ttggccgttc gtttctgttg acggtaactc tatctctgac      900

ggtgttccgg gtccggttac ccagtctatc atccgtcgtt actgggaact gaacgttgaa      960

ccttcttgcc tgctgacccc ggtacagtac taa                                   993


