                         SEQUENCE LISTING

<110>  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
 
<120>  INHIBITORY CHIMERIC ANTIGEN RECEPTOR PREVENTS ON-TARGET OFF-TUMOR
        EFFECTS OF ADOPTIVE CELL THERAPY

<130>  MDAC.P1275WO/1001208176

<140>  Filed Concurrently Herewith
<141>  2022-05-25

<150>  US 63/193,363
<151>  2021-05-26

<150>  US 63/296,785
<151>  2022-01-05

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  1
attctgattg ggacctcagt ggtcatcatc ctcttcatcc tcctcttctt tctccttcat       60

cgctggtgct ccaacaaaaa aaatgctgcg gtaatggacc aagagtctgc aggaaacaga      120

acagcgaata gcgaggactc tgatgaacaa gaccctcagg aggtgacata cacacagttg      180

aatcactgcg ttttcacaca gagaaaaatc actcgccctt ctcagaggcc caagacaccc      240

ccaacagata tcatcgtgta cacggaactt ccaaatgctg agtccagatc caaagttgtc      300

tcctgccca                                                              309


<210>  2
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptides

<400>  2

Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Phe 
1               5                   10                  15      


Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met 
            20                  25                  30          


Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp 
        35                  40                  45              


Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln Leu Asn His Cys Val 
    50                  55                  60                  


Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro 
65                  70                  75                  80  


Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro Asn Ala Glu Ser Arg 
                85                  90                  95      


Ser Lys Val Val Ser Cys Pro 
            100             


<210>  3
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  3
gttgtgatcg gcatcttggt ggccgtcatc ctactgctcc tcctcctcct cctcctcttc       60

ctcatcctcc gacatcgacg tcagggcaaa cactggacat cgacccagag aaaggctgat      120

ttccaacatc ctgcaggggc tgtggggcca gagcccacag acagaggcct gcagtggagg      180

tccagcccag ctgccgatgc ccaggaagaa aacctctatg ctgccgtgaa gcacacacag      240

cctgaggatg gggtggagat ggacactcgg cagagcccac acgatgaaga cccccaggca      300

gtgacgtatg ccgaggtgaa acactccaga cctaggagag aaatggcctc tcctccttcc      360

ccactgtctg gggaattcct ggacacaaag gacagacagg cggaagagga caggcagatg      420

gacactgagg ctgctgcatc tgaagccccc caggatgtga cctacgccca gctgcacagc      480

ttgaccctca gacgggaggc aactgagcct cctccatccc aggaagggcc ctctccagct      540

gtgcccagca tctacgccac tctggccatc cac                                   573


<210>  4
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptides

<400>  4

Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr 
            20                  25                  30          


Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly 
        35                  40                  45              


Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala 
    50                  55                  60                  


Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro 
65                  70                  75                  80  


Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro 
                85                  90                  95      


Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu 
            100                 105                 110         


Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys 
        115                 120                 125             


Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala 
    130                 135                 140                 


Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr 
145                 150                 155                 160 


Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser 
                165                 170                 175     


Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
            180                 185                 


<210>  5
<211>  612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  5
attctgattg ggacctcagt ggtcatcatc ctcttcatcc tcctcttctt tctccttcat       60

cgctggtgct ccaacaaaaa aaatgctgcg gtaatggacc aagagtctgc aggaaacaga      120

acagcgaata gcgaggactc tgatgaacaa gaccctcagg aggtgacata cacacagttg      180

aatcactgcg ttttcacaca gagaaaaatc actcgccctt ctcagaggcc caagacaccc      240

ccaacagata tcatcgtgta cacggaactt ccaaatgctg agtccagatc caaagttgtc      300

tcctgcccac atcgccagaa tcagataaag caggggcccc ccagaagcaa ggacgaggag      360

cagaagccac agcagaggcc tgacctggct gttgatgttc tagagaggac agcagacaag      420

gccacagtca atggacttcc tgagaaggac agagagacgg acacctcggc cctggctgca      480

gggagttccc aggaggtgac gtatgctcag ctggaccact gggccctcac acagaggaca      540

gcccgggctg tgtccccaca gtccacaaag cccatggccg agtccatcac gtatgcagcc      600

gttgccagac ac                                                          612


<210>  6
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptides

<400>  6

Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Phe 
1               5                   10                  15      


Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met 
            20                  25                  30          


Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp 
        35                  40                  45              


Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln Leu Asn His Cys Val 
    50                  55                  60                  


Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro 
65                  70                  75                  80  


Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro Asn Ala Glu Ser Arg 
                85                  90                  95      


Ser Lys Val Val Ser Cys Pro His Arg Gln Asn Gln Ile Lys Gln Gly 
            100                 105                 110         


Pro Pro Arg Ser Lys Asp Glu Glu Gln Lys Pro Gln Gln Arg Pro Asp 
        115                 120                 125             


Leu Ala Val Asp Val Leu Glu Arg Thr Ala Asp Lys Ala Thr Val Asn 
    130                 135                 140                 


Gly Leu Pro Glu Lys Asp Arg Glu Thr Asp Thr Ser Ala Leu Ala Ala 
145                 150                 155                 160 


Gly Ser Ser Gln Glu Val Thr Tyr Ala Gln Leu Asp His Trp Ala Leu 
                165                 170                 175     


Thr Gln Arg Thr Ala Arg Ala Val Ser Pro Gln Ser Thr Lys Pro Met 
            180                 185                 190         


Ala Glu Ser Ile Thr Tyr Ala Ala Val Ala Arg His 
        195                 200                 


<210>  7
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  7
attctgattg ggacctcagt ggtcatcatc ctcttcatcc tcctcttctt tctccttcat       60

cgctggtgct ccaacaaaaa aaatgctgcg gtaatggacc aagagtctgc aggaaacaga      120

acagcgaata gcgaggactc tgatgaacaa gaccctcagg aggtgacata cacacagttg      180

aatcactgcg ttttcacaca gagaaaaatc actcgccctt ctcagaggcc caagacaccc      240

ccaacagata tcatcgtgta cacggaactt ccaaatgctg agtccagatc caaagttgtc      300

tcctgcccaa aagaaccggc gagcccgctg gataaatgcc attataccaa agataacggc      360

cagtttgatc agagcgcgaa acagctgaac ctggaagcgt ataccattga acaggaaacc      420

gcgctgatta gcaacaaaaa cggcaaaccg aaacgccagc agcgcaaacc gaacccgccg      480

ctgaacctgg atagctatat tgtgggccag aacgatatg                             519


<210>  8
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptides

<400>  8

Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Phe 
1               5                   10                  15      


Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met 
            20                  25                  30          


Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp 
        35                  40                  45              


Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln Leu Asn His Cys Val 
    50                  55                  60                  


Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro 
65                  70                  75                  80  


Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro Asn Ala Glu Ser Arg 
                85                  90                  95      


Ser Lys Val Val Ser Cys Pro Lys Glu Pro Ala Ser Pro Leu Asp Lys 
            100                 105                 110         


Cys His Tyr Thr Lys Asp Asn Gly Gln Phe Asp Gln Ser Ala Lys Gln 
        115                 120                 125             


Leu Asn Leu Glu Ala Tyr Thr Ile Glu Gln Glu Thr Ala Leu Ile Ser 
    130                 135                 140                 


Asn Lys Asn Gly Lys Pro Lys Arg Gln Gln Arg Lys Pro Asn Pro Pro 
145                 150                 155                 160 


Leu Asn Leu Asp Ser Tyr Ile Val Gly Gln Asn Asp Met 
                165                 170             


<210>  9
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Nucleotide

<400>  9
attctgattg ggacctcagt ggtcatcatc ctcttcatcc tcctcttctt tctccttcat       60

cgctggtgct ccaacaaaaa aaatgctgcg gtaatggacc aagagtctgc aggaaacaga      120

acagcgaata gcgaggactc tgatgaacaa gaccctcagg aggtgacata cacacagttg      180

aatcactgcg ttttcacaca gagaaaaatc actcgccctt ctcagaggcc caagacaccc      240

ccaacagata tcatcgtgta cacggaactt ccaaatgctg agtccagatc caaagttgtc      300

tcctgcccaa ggatgtttca gaaatggatc aaagctggtg accattcaga gctgtcccag      360

aaccccaagc aggctgccac gcagagtgag ctgcactacg caaatctgga gctgctgatg      420

tggcctctgc aggaaaagcc agcaccacca agggaggtgg aggtggaata cagcactgtg      480

gcctccccca gggaagaact tcactatgcc tcggtggtgt ttgattctaa caccaacagg      540

atagctgctc agaggcctcg ggaggaggaa ccagattcag attacagtgt gataaggaag      600

aca                                                                    603


<210>  10
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptides

<400>  10

Ile Leu Ile Gly Thr Ser Val Val Ile Ile Leu Phe Ile Leu Leu Phe 
1               5                   10                  15      


Phe Leu Leu His Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met 
            20                  25                  30          


Asp Gln Glu Ser Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp 
        35                  40                  45              


Glu Gln Asp Pro Gln Glu Val Thr Tyr Thr Gln Leu Asn His Cys Val 
    50                  55                  60                  


Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro 
65                  70                  75                  80  


Pro Thr Asp Ile Ile Val Tyr Thr Glu Leu Pro Asn Ala Glu Ser Arg 
                85                  90                  95      


Ser Lys Val Val Ser Cys Pro Arg Met Phe Gln Lys Trp Ile Lys Ala 
            100                 105                 110         


Gly Asp His Ser Glu Leu Ser Gln Asn Pro Lys Gln Ala Ala Thr Gln 
        115                 120                 125             


Ser Glu Leu His Tyr Ala Asn Leu Glu Leu Leu Met Trp Pro Leu Gln 
    130                 135                 140                 


Glu Lys Pro Ala Pro Pro Arg Glu Val Glu Val Glu Tyr Ser Thr Val 
145                 150                 155                 160 


Ala Ser Pro Arg Glu Glu Leu His Tyr Ala Ser Val Val Phe Asp Ser 
                165                 170                 175     


Asn Thr Asn Arg Ile Ala Ala Gln Arg Pro Arg Glu Glu Glu Pro Asp 
            180                 185                 190         


Ser Asp Tyr Ser Val Ile Arg Lys Thr 
        195                 200     


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic crRNA

<400>  11
ctaggtccga aacattccac cgg                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic crRNA

<400>  12
cgaggaacct ctagtggtga agg                                               23


