                         SEQUENCE LISTING

<110>  MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120>  T CELL RECEPTORS TARGETING RAS MUTATIONS AND USES THEREOF

<130>  072734.1354

<150>  US 63/192,783
<151>  2021-05-25

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  RAS peptide

<400>  1

Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   


<210>  2
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  RAS peptide

<400>  2

Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  RAS peptide

<400>  3

Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10  


<210>  4
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  CDR 1 alpha-chain

<400>  4

Thr Ala Thr Gly Tyr Pro Ser 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  CDR2 alpha-chain

<400>  5

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  6
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  CDR3 alpha-chain

<400>  6

Cys Ala Leu Ser Asp Arg Val Gly Gly Ala Arg Leu Met Phe 
1               5                   10                  


<210>  7
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  CDR 1 beta-chain

<400>  7

Met Gly His Asp Lys 
1               5   


<210>  8
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR2 beta-chain

<400>  8

Ser Tyr Gly Val Asn Ser 
1               5       


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  CDR3 beta-chain

<400>  9

Cys Ala Ser Ser Glu Gly Leu Tyr Asn Glu Gln Phe Phe 
1               5                   10              


<210>  10
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(132)
<223>  alpha-chain variable

<400>  10

Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asp Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Asp Arg Val Gly Gly Ala Arg Leu Met Phe Gly Asp Gly Thr Gln Leu 
        115                 120                 125             


Val Val Lys Pro 
    130         


<210>  11
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(131)
<223>  beta-chain variable

<400>  11

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Glu Gly Leu Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  12
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(273)
<223>  Full alpha-chain

<400>  12

Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asp Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Asp Arg Val Gly Gly Ala Arg Leu Met Phe Gly Asp Gly Thr Gln Leu 
        115                 120                 125             


Val Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  13
<211>  310
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(310)
<223>  Full beta-chain

<400>  13

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Glu Gly Leu Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
    130                 135                 140                 


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
225                 230                 235                 240 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asp Ser Arg Gly 
305                 310 


<210>  14
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  CDR 1 alpha-chain

<400>  14

Thr Ser Glu Asn Asn Tyr Tyr 
1               5           


<210>  15
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  CDR2 alpha-chain

<400>  15

Gln Glu Ala Tyr Lys Gln Gln Asn 
1               5               


<210>  16
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  CDR3 alpha-chain

<400>  16

Cys Ala Phe Met Tyr Pro Ser Gln Gly Gly Ser Glu Lys Leu Val Phe 
1               5                   10                  15      


<210>  17
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  CDR 1 beta-chain

<400>  17

Ser Gly His Asn Thr 
1               5   


<210>  18
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR2 beta-chain

<400>  18

Tyr Tyr Arg Glu Glu Glu 
1               5       


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  CDR3 beta-chain

<400>  19

Cys Ala Ser Ser Ser Pro Gly Phe Arg Ser Tyr Gly Tyr Thr Phe 
1               5                   10                  15  


<210>  20
<211>  137
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(137)
<223>  alpha-chain variable

<400>  20

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Met Tyr Pro Ser Gln Gly Gly Ser Glu Lys Leu Val Phe Gly 
        115                 120                 125             


Lys Gly Met Lys Leu Thr Val Asn Pro 
    130                 135         


<210>  21
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(133)
<223>  beta-chain variable

<400>  21

Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His 
        35                  40                  45              


Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Pro Gly Phe Arg Ser Tyr Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val 
    130             


<210>  22
<211>  278
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(278)
<223>  Full alpha-chain

<400>  22

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Met Tyr Pro Ser Gln Gly Gly Ser Glu Lys Leu Val Phe Gly 
        115                 120                 125             


Lys Gly Met Lys Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Asp Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp 
                165                 170                 175     


Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met 
            180                 185                 190         


Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe 
        195                 200                 205             


Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe 
    210                 215                 220                 


Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser 
225                 230                 235                 240 


Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly 
                245                 250                 255     


Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            260                 265                 270         


Leu Arg Leu Trp Ser Ser 
        275             


<210>  23
<211>  310
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(310)
<223>  Full beta-chain

<400>  23

Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His 
        35                  40                  45              


Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Pro Gly Phe Arg Ser Tyr Gly Tyr Thr Phe Gly Ser Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Phe 
305                 310 


<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  CDR 1 alpha-chain

<400>  24

Thr Ser Glu Ser Asp Tyr Tyr 
1               5           


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  CDR3 alpha-chain

<400>  25

Cys Ala Tyr Arg Ser Asp Gly Gly Ala Thr Asn Lys Leu Ile Phe 
1               5                   10                  15  


<210>  26
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  CDR 1 beta-chain

<400>  26

Met Asn His Glu Tyr 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR2 beta-chain

<400>  27

Ser Met Asn Val Glu Val 
1               5       


<210>  28
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  CDR3 beta-chain

<400>  28

Cys Ala Ser Ser Leu Gly Ala Gly Gly Tyr Asn Ser Pro Leu His Phe 
1               5                   10                  15      


<210>  29
<211>  136
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(136)
<223>  alpha-chain variable

<400>  29

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Arg Ser Asp Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr 
        115                 120                 125             


Gly Thr Leu Leu Ala Val Gln Pro 
    130                 135     


<210>  30
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(134)
<223>  beta-chain variable

<400>  30

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Ala Gly Gly Tyr Asn Ser Pro Leu His Phe Gly Asn Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr 
    130                 


<210>  31
<211>  277
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(277)
<223>  Full alpha-chain

<400>  31

Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu 
1               5                   10                  15      


Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Tyr Arg Ser Asp Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr 
        115                 120                 125             


Gly Thr Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  32
<211>  311
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(311)
<223>  Full beta-chain

<400>  32

Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Leu Gly Ala Gly Gly Tyr Asn Ser Pro Leu His Phe Gly Asn Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe 
305                 310     


<210>  33
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR 1 alpha-chain

<400>  33

Asn Ser Ala Phe Gln Tyr 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR2 alpha-chain

<400>  34

Thr Tyr Ser Ser Gly Asn 
1               5       


<210>  35
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  CDR3 alpha-chain

<400>  35

Cys Ala Met Gly Ala Leu Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  36
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  CDR 1 beta-chain

<400>  36

Ser Gly His Arg Ser 
1               5   


<210>  37
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR2 beta-chain

<400>  37

Tyr Phe Ser Glu Thr Gln 
1               5       


<210>  38
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  CDR3 beta-chain

<400>  38

Cys Ala Ser Ser Leu Ser Ser Gly Thr Gly Thr Glu Ala Phe Phe 
1               5                   10                  15  


<210>  39
<211>  137
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(137)
<223>  alpha-chain variable

<400>  39

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Gly Ala Leu Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly 
        115                 120                 125             


Lys Gly Thr Lys Leu Ser Val Ile Pro 
    130                 135         


<210>  40
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(133)
<223>  beta-chain variable

<400>  40

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ser Ser Gly Thr Gly Thr Glu Ala Phe Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val 
    130             


<210>  41
<211>  278
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(278)
<223>  Full alpha-chain

<400>  41

Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Gly Ala Leu Asn Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly 
        115                 120                 125             


Lys Gly Thr Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp 
                165                 170                 175     


Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met 
            180                 185                 190         


Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe 
        195                 200                 205             


Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe 
    210                 215                 220                 


Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser 
225                 230                 235                 240 


Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly 
                245                 250                 255     


Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            260                 265                 270         


Leu Arg Leu Trp Ser Ser 
        275             


<210>  42
<211>  310
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(310)
<223>  Full beta-chain

<400>  42

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ser Ser Gly Thr Gly Thr Glu Ala Phe Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Phe 
305                 310 


<210>  43
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR 1 alpha-chain

<400>  43

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  44
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  CDR2 alpha-chain

<400>  44

Ile Phe Ser Asn Met Asp Met 
1               5           


<210>  45
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  CDR3 alpha-chain

<400>  45

Cys Ala Glu Arg Asp Ala Gly Asn Asn Arg Lys Leu Ile Trp 
1               5                   10                  


<210>  46
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  CDR2 beta-chain

<400>  46

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  CDR3 beta-chain

<400>  47

Cys Ala Ser Ser Leu Glu Gly Gly Asp Thr Gln Tyr Phe 
1               5                   10              


<210>  48
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(133)
<223>  alpha-chain variable

<400>  48

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Asp Ala Gly Asn Asn Arg Lys Leu Ile Trp Gly Leu Gly Thr Ser 
        115                 120                 125             


Leu Ala Val Asn Pro 
    130             


<210>  49
<211>  132
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(132)
<223>  beta-chain variable

<400>  49

Met Gly Thr Arg Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Ala 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Glu Gly Gly Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  50
<211>  274
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(274)
<223>  Full alpha-chain

<400>  50

Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Arg Asp Ala Gly Asn Asn Arg Lys Leu Ile Trp Gly Leu Gly Thr Ser 
        115                 120                 125             


Leu Ala Val Asn Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  51
<211>  311
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(311)
<223>  Full beta-chain

<400>  51

Met Gly Thr Arg Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Ala 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Glu Gly Gly Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  52
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  2A peptide

<400>  52

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  53
<211>  141
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(141)
<223>  Human alpha chain constant region

<400>  53

Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
1               5                   10                  15      


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
            20                  25                  30          


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
        35                  40                  45              


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
    50                  55                  60                  


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
65                  70                  75                  80  


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
                85                  90                  95      


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
            100                 105                 110         


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
        115                 120                 125             


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140     


<210>  54
<211>  137
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(137)
<223>  Mouse alpha chain constant region (cysteine-modification and LVL 
       modification in transmembrane domain underlined)

<400>  54

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  55
<211>  177
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(177)
<223>  Human beta chain constant region

<400>  55

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  56
<211>  173
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(173)
<223>  Mouse beta chain constant region (cysteine-modification 
       underlined)

<400>  56

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  57
<211>  179
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(179)
<223>  Human beta chain constant region

<400>  57

Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Ser Arg Gly 
            


<210>  58
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  CDR 1 beta-chain

<400>  58

Ser Gly His Val Ser 
1               5   


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GEM

<400>  59

Ala Val Phe Gly Ala Gly Gly Val Gly Lys 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  R-Ras

<400>  60

Val Val Val Gly Gly Gly Gly Val Gly Lys 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  ABCF1

<400>  61

Ser Thr Ser Pro Ser Asp Lys Val Val Lys 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  BMS1

<400>  62

Val Val Met Gly Pro Pro Lys Val Gly Lys 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CD166

<400>  63

Asn Val Phe Glu Ala Pro Thr Ile Val Lys 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CFA47

<400>  64

Met Val Phe Asp Ser Pro Thr Ile Gly Lys 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CK049

<400>  65

Tyr Ser Cys Pro Pro Pro Ala Leu Val Lys 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CL056

<400>  66

Ser Ser Gln Ser Ala Pro Thr Thr Gly Lys 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CPNS1

<400>  67

Ala Val Met Asp Ser Asp Thr Thr Gly Lys 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CPNS2

<400>  68

Ser Val Met Asp Ser Asp Thr Thr Gly Lys 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  FLNA

<400>  69

Val Thr Ile Asp Gly Pro Ser Lys Val Lys 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GRIN1

<400>  70

Gly Thr Ala Gly Pro Pro Ser Ala Val Lys 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  IGM

<400>  71

Leu Thr Glu Ser Gly Pro Ala Leu Val Lys 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  KZF4

<400>  72

His Ser Val Ser Ser Pro Thr Val Gly Lys 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  IL17F

<400>  73

Lys Thr Leu His Gly Pro Ala Met Val Lys 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  K1671

<400>  74

Thr Thr Lys Ser Gly Pro Ala Leu Gly Lys 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  KAD3

<400>  75

Val Ile Met Gly Ala Pro Gly Ser Gly Lys 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  LEGL

<400>  76

Ser Val Ala Asp Ser Asp Ala Val Val Lys 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  RL7A

<400>  77

Lys Val Ala Pro Ala Pro Ala Val Val Lys 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  RSLAA

<400>  78

Ala Val Leu Gly Ala Pro Gly Val Gly Lys 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SALL1

<400>  79

Ser Ala Thr Ser Pro Pro Gly Ser Val Lys 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SEZ6

<400>  80

Leu Ser Leu Glu Ala Pro Thr Val Gly Lys 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SHAN3

<400>  81

Thr Thr Val Pro Ser Pro Ala Ser Gly Lys 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GEM

<400>  82

Ala Val Phe Gly Ala Gly Gly Val Gly Lys 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  R-Ras

<400>  83

Val Val Val Gly Gly Gly Gly Val Gly Lys 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CHADL

<400>  84

Arg Gln Cys Gly Ala Asp Lys Val Gly Lys 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  DAZP1

<400>  85

Asn Asn Ser Gly Ala Asp Glu Ile Gly Lys 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  FMNL1

<400>  86

Gln Glu Ala Gly Ala Asp Thr Pro Gly Lys 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GTR14

<400>  87

Gln Ala His Gly Ala Asp Arg Ser Gly Lys 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GTR3

<400>  88

Gln Ala His Gly Ala Asp Arg Ser Gly Lys 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  MICU1

<400>  89

Tyr Phe Phe Gly Ala Asp Leu Lys Gly Lys 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  ADA2C

<400>  90

Gly Ala Gly Gly Ala Asp Gly Gln Gly Ala 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CC88B

<400>  91

Leu Arg Leu Gly Ala Asp Gly Ala Gly Ser 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  DYH8

<400>  92

Lys Val Ala Gly Ala Asp Gly Lys Gly Ile 
1               5                   10  


<210>  93
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  EFMT2

<400>  93

Met Ser Ser Gly Ala Asp Gly Gly Gly Gly 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  FOXL2

<400>  94

Ala Gly Ala Gly Ala Asp Gly Tyr Gly Tyr 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  HMCN2

<400>  95

Ile Lys Gln Gly Ala Asp Gly Ser Gly Thr 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  MARF1

<400>  96

Leu Lys Leu Gly Ala Asp Gly Ser Gly Pro 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  MED13

<400>  97

Asn Asn Asp Gly Ala Asp Gly Met Gly Ile 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  MYLK

<400>  98

Gly Gly Val Gly Ala Asp Gly Gly Gly Ser 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  NDF2

<400>  99

Thr Glu Gln Gly Ala Asp Gly Ala Gly Arg 
1               5                   10  


<210>  100
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  PBX3

<400>  100

Gly His Glu Gly Ala Asp Gly Asp Gly Arg 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  PER1

<400>  101

Pro Leu Glu Gly Ala Asp Gly Gly Gly Asp 
1               5                   10  


<210>  102
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  ZN646

<400>  102

Pro Glu Asp Gly Ala Asp Gly Trp Gly Pro 
1               5                   10  


<210>  103
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  HIC1

<400>  103

Gly Val Pro Gly Pro Asp Gly Lys Gly Lys 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  TBL3

<400>  104

Leu Ser Ser Gly Ser Asp Gly Leu Val Lys 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  TUTLA

<400>  105

Ile Ser Gln Gly Ala Asp Gly Arg Gly Lys 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GEM

<400>  106

Ala Val Phe Gly Ala Gly Gly Val Gly Lys 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  R-Ras

<400>  107

Val Val Val Gly Gly Gly Gly Val Gly Lys 
1               5                   10  


<210>  108
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  BY55

<400>  108

Arg Asp Pro Gly Ile Asp Gly Val Gly Glu 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CO6A3

<400>  109

Gly Asp Asp Gly Arg Asp Gly Val Gly Ser 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CO8A2

<400>  110

Gly Pro Pro Gly Val Asp Gly Val Gly Val 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  COBA1

<400>  111

Gly Pro Ala Gly Gln Asp Gly Val Gly Gly 
1               5                   10  


<210>  112
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  COIA1

<400>  112

Gly Asp Pro Gly Lys Asp Gly Val Gly Gln 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  EFGM

<400>  113

Glu Val Lys Gly Lys Asp Gly Val Gly Ala 
1               5                   10  


<210>  114
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  MEIS1

<400>  114

His Tyr Gly Gly Met Asp Gly Val Gly Ile 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  MEIS2

<400>  115

His Tyr Gly Gly Met Asp Gly Val Gly Val 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  PUR2

<400>  116

Leu Ala Ser Gly Thr Asp Gly Val Gly Thr 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  USH1G

<400>  117

Glu Asp Gly Gly Leu Asp Gly Val Gly Ala 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  ABCF1

<400>  118

Cys Ile Val Gly Pro Asn Gly Val Gly Lys 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  AGRIN

<400>  119

Pro Val Cys Gly Ser Asp Gly Val Thr Tyr 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  CGAT2

<400>  120

Arg Asn Val Gly Ala Asn Gly Ile Gly Tyr 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  DNHD1

<400>  121

Thr Val Leu Gly Pro Asn Gly Val Gly Lys 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  IBP7

<400>  122

Pro Val Cys Gly Ser Asp Gly Thr Thr Tyr 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  NLRP9

<400>  123

Val Leu Glu Gly Pro Asp Gly Ile Gly Lys 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  PRA19

<400>  124

Lys Leu Phe Ile Ser Asp Gly Cys Gly Tyr 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SMC5

<400>  125

Met Ile Val Gly Ala Asn Gly Thr Gly Lys 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SO3A1

<400>  126

Pro Val Cys Gly Ala Asp Gly Ile Thr Tyr 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SO5A1

<400>  127

Pro Val Cys Gly Ser Asp Gly Ile Thr Tyr 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SOCS7

<400>  128

Gly Ser Gly Gly Gly Asp Gly Thr Gly Lys 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  SUCB2

<400>  129

Cys Ala Ile Ile Ala Asn Gly Ile Thr Lys 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GEM

<400>  130

Ala Val Phe Gly Ala Gly Gly Val Gly Lys 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  R-Ras

<400>  131

Val Val Val Gly Gly Gly Gly Val Gly Lys 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  FRPD4

<400>  132

Lys Ser Lys Leu Ala Asp Gly Glu Gly Lys 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  TAF6

<400>  133

Gly Ala Thr Thr Ala Asp Gly Lys Gly Lys 
1               5                   10  


<210>  134
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  TUTLA

<400>  134

Ile Ser Gln Gly Ala Asp Gly Arg Gly Lys 
1               5                   10  


<210>  135
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  DCAF7

<400>  135

Ala Ser Val Gly Ala Asp Gly Ser Val Arg 
1               5                   10  


<210>  136
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  ELP2

<400>  136

Val Ser Ala Ala Ala Asp Ser Ala Val Arg 
1               5                   10  


<210>  137
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  FRPD1

<400>  137

Lys Val Ala Ala Ala Asp Gly Pro Ala Arg 
1               5                   10  


<210>  138
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  INO80

<400>  138

Ser Ser Leu Ala Pro Asp Ser Leu Val Arg 
1               5                   10  


<210>  139
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  KI26A

<400>  139

Pro Val Ala Gly Pro Asp Gly Leu Ser Lys 
1               5                   10  


<210>  140
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  PRP4

<400>  140

Ala Ser Cys Ala Ala Asp Gly Ser Val Lys 
1               5                   10  


<210>  141
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  GEM

<400>  141

Ala Val Phe Gly Ala Gly Gly Val Gly Lys 
1               5                   10  


<210>  142
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  R-Ras

<400>  142

Val Val Val Gly Gly Gly Gly Val Gly Lys 
1               5                   10  


<210>  143
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  HRAS

<400>  143

Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu Ser Gly Pro Gly 
1               5                   10                  15      


Cys Met Ser Cys Lys Cys Val Leu Ser 
            20                  25  


<210>  144
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  NRAS

<400>  144

Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp Gly Thr Gln Cys 
1               5                   10                  15      


Cys Met Gly Leu Pro Cys Val Val Met 
            20                  25  


<210>  145
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  KRAS4A

<400>  145

Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys Thr Pro Gly Cys 
1               5                   10                  15      


Val Lys Ile Lys Lys Cys Ile Ile Met 
            20                  25  


<210>  146
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  KRAS4B

<400>  146

Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ser Lys Thr Lys Cys Val Ile Met 
            20                  


