                         SEQUENCE LISTING

<110>  Innovative Cellular Therapeutics Holdings Limited
       Innovative Cellular Therapeutics, Inc
 
<120>  Modified Chimeric Antigen Receptor with Enhanced Capability of 
       IL-12 Release and Use thereof

<130>  I071-0094US

<150>  63/193,837
<151>  2021-05-17

<150>  63/231,976
<151>  2021-08-11

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Gly Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Lys Thr Trp Pro Arg Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr 
                165                 170                 175     


Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Glu Arg Gly Tyr Thr Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Cys Val Arg Cys Arg His Arg Arg 
                325                 330                 335     


Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys 
            340                 345                 350         


Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
        355                 360                 365             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    370                 375                 380                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                405                 410                 415     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            420                 425                 430         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        435                 440                 445             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    450                 455                 460                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
465                 470                 475                 480 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                485                 490                 495     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            500                 505                 510         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520         


<210>  2
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Gly Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Lys Thr Trp Pro Arg Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr 
                165                 170                 175     


Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Glu Arg Gly Tyr Thr Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala 
                485                 490                 495     


Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys 
            500                 505                 510         


Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
        515                 520                 525 


<210>  3
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Gly Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Lys Thr Trp Pro Arg Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr 
                165                 170                 175     


Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Glu Arg Gly Tyr Thr Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
            260                 265                 270         


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
        275                 280                 285             


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
    290                 295                 300                 


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
305                 310                 315                 320 


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
                325                 330                 335     


His Arg Phe Gln Lys Thr Cys Ser Pro Ile Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  4
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Gly Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Lys Thr Trp Pro Arg Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr 
                165                 170                 175     


Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Glu Arg Gly Tyr Thr Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
            260                 265                 270         


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
        275                 280                 285             


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
    290                 295                 300                 


Phe Phe Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Cys Val Arg Cys 
    450                 455                 460                 


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
465                 470                 475                 480 


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
                485                 490                 495     


Cys Ser Pro Ile 
            500 


<210>  5
<211>  853
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Ser Val Ser Arg Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Gly Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Lys Thr Trp Pro Arg Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr 
                165                 170                 175     


Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Asn His Arg Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Glu Arg Gly Tyr Thr Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 


Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
            500                 505                 510         


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
        515                 520                 525             


Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
    530                 535                 540                 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
545                 550                 555                 560 


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
                565                 570                 575     


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
            580                 585                 590         


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser 
        595                 600                 605             


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Pro Arg 
    610                 615                 620                 


Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
                645                 650                 655     


Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
            660                 665                 670         


Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg 
        675                 680                 685             


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Arg 
    690                 695                 700                 


Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
705                 710                 715                 720 


Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu Ser Ser Val Thr 
                725                 730                 735     


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Gly Tyr Thr 
            740                 745                 750         


Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        755                 760                 765             


Ser Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr 
    770                 775                 780                 


Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val 
785                 790                 795                 800 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                805                 810                 815     


Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg 
            820                 825                 830         


Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys 
        835                 840                 845             


Thr Cys Ser Pro Ile 
    850             


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  7
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  8
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  9
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  10
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  10

His Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln 
1               5                   10                  15      


Phe Tyr Lys 
            


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Val Cys Lys Cys Pro Arg Pro Val 
1               5                   


<210>  12
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro 
            20          


<210>  13
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  14
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile 
        35                  40  


<210>  15
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys 
1               5                   10                  15      


Pro 
    


<210>  16
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser 
        35                  40                  45              


Ser Val Asp Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Phe Trp Ile Tyr Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Ser Tyr Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Gly Glu Val Met Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr Trp Ile 
                165                 170                 175     


Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
            180                 185                 190         


Ile Leu Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Phe Thr Ala His Thr Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Ser Asn Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  17
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile Lys Arg Gly Arg Lys Lys Leu Leu 
        35                  40                  45              


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    50                  55                  60                  


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
65                  70                  75                  80  


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                85                  90                  95      


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            100                 105                 110         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        115                 120                 125             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    130                 135                 140                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
145                 150                 155                 160 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                165                 170                 175     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            180                 185                 190         


Pro Arg 
        


<210>  18
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala 
            20                  25                  30          


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
        35                  40                  45              


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
    50                  55                  60                  


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
65                  70                  75                  80  


Cys Ser Pro Ile Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                85                  90                  95      


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            100                 105                 110         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        115                 120                 125             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    130                 135                 140                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
145                 150                 155                 160 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                165                 170                 175     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            180                 185                 190         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        195                 200                 205             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    210                 215                 220                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
225                 230                 235             


<210>  19
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Lys Thr Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Ala Val Phe Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn His Arg 
                165                 170                 175     


Gly Asn Thr Asn Asp Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Val Asp Thr Ser Lys Asn Gln Phe Ala Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Arg Gly Tyr Thr 
    210                 215                 220                 


Tyr Gly Asn Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  20
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys 
1               5                   10                  15      


Pro Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            20                  25                  30          


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        35                  40                  45              


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    50                  55                  60                  


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
65                  70                  75                  80  


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                85                  90                  95      


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            100                 105                 110         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        115                 120                 125             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    130                 135                 140                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
145                 150                 155                 160 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                165                 170     


<210>  21
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  21

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        35                  40                  45              


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    50                  55                  60                  


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
65                  70                  75                  80  


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                85                  90                  95      


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            100                 105                 110         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        115                 120                 125             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    130                 135                 140                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
145                 150                 155                 160 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                165                 170                 175     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185     


<210>  22
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

His Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln 
1               5                   10                  15      


Phe Tyr Lys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            20                  25                  30          


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        35                  40                  45              


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    50                  55                  60                  


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
65                  70                  75                  80  


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                85                  90                  95      


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            100                 105                 110         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        115                 120                 125             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    130                 135                 140                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
145                 150                 155                 160 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                165                 170             


<210>  23
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Arg Val Cys Lys Cys Pro Arg Pro Val Lys Arg Gly Arg Lys Lys Leu 
1               5                   10                  15      


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            20                  25                  30          


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        35                  40                  45              


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  24
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr 
65      


<210>  25
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser 
        35                  40                  45              


Ser Val Asp Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Phe Trp Ile Tyr Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Ser Tyr Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Gly Glu Val Met Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr Trp Ile 
                165                 170                 175     


Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
            180                 185                 190         


Ile Leu Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Phe Thr Ala His Thr Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Ser Asn Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro 
            260                 265                 270         


Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly 
        275                 280                 285             


Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val 
    290                 295                 300                 


Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys 
305                 310                 315                 320 


Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln 
                325                 330                 335     


Lys Thr Cys Ser Pro Ile Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  26
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser 
        35                  40                  45              


Ser Val Asp Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Phe Trp Ile Tyr Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Ser Tyr Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Gly Glu Val Met Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr Trp Ile 
                165                 170                 175     


Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
            180                 185                 190         


Ile Leu Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Phe Thr Ala His Thr Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Ser Asn Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro 
            260                 265                 270         


Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly 
        275                 280                 285             


Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg Cys Val Arg Cys Arg His Arg Arg 
    450                 455                 460                 


Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys 
465                 470                 475                 480 


Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
                485                 490                 495     


<210>  27
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser 
        35                  40                  45              


Ser Val Asp Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Phe Trp Ile Tyr Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Ser Tyr Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Gly Glu Val Met Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr Trp Ile 
                165                 170                 175     


Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
            180                 185                 190         


Ile Leu Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Phe Thr Ala His Thr Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Ser Asn Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Met 
    290                 295                 300                 


Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
305                 310                 315                 320 


Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala 
                325                 330                 335     


Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys 
            340                 345                 350         


Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile Lys Arg Gly 
        355                 360                 365             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    370                 375                 380                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
385                 390                 395                 400 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
                405                 410                 415     


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            420                 425                 430         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        435                 440                 445             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    450                 455                 460                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
465                 470                 475                 480 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                485                 490                 495     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            500                 505                 510         


Met Gln Ala Leu Pro Pro Arg 
        515                 


<210>  28
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
            20                  25                  30          


Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser 
        35                  40                  45              


Ser Val Asp Tyr Ile His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro 
    50                  55                  60                  


Lys Phe Trp Ile Tyr Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Ser Tyr Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Gln Ser Gly Gly Glu Val Met Lys Pro Gly Ala Ser Val 
145                 150                 155                 160 


Lys Leu Ser Cys Lys Ala Thr Gly Tyr Thr Phe Thr Gly Tyr Trp Ile 
                165                 170                 175     


Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
            180                 185                 190         


Ile Leu Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys Gly 
        195                 200                 205             


Lys Ala Thr Phe Thr Ala His Thr Ser Ser Asn Thr Ala Tyr Met Gln 
    210                 215                 220                 


Leu Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Asp Ser Asn Ser Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Lys Val Ala Lys Lys Pro Thr Asn 
                325                 330                 335     


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
            340                 345                 350         


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
        355                 360                 365             


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
    370                 375                 380                 


Val Gln Glu Arg Gln Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg 
            500     


<210>  29
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  29

His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr 
1               5                   10                  15      


Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr 
            20                  25                  30          


Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu 
        35                  40                  45              


Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val 
    50                  55                  60                  


Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu 
65                  70                  75                  80  


Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr 
                85                  90                  95      


Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser 
            100                 105                 110         


Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu 
        115                 120                 125             


Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro 
    130                 135                 140                 


Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu 
145                 150                 155                 160 


Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met 
                165                 170                 175     


Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser 
            180                 185                 190         


Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu 
        195                 200                 205             


Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys 
    210                 215                 220                 


Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro 
225                 230                 235                 240 


Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser 
                245                 250                 255     


Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr 
            260                 265                 270         


Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp 
        275                 280                 285             


Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp 
    290                 295                 300                 


Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp 
305                 310                 315                 320 


Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys 
                325                 330                 335     


Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met 
            340                 345                 350         


Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala 
        355                 360                 365             


Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr 
    370                 375                 380                 


Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr 
385                 390                 395                 400 


Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro 
                405                 410                 415     


Gly Gln Glu Asp Gly Ala 
            420         


<210>  30
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  30

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210>  31
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln Trp Ile 
1               5                   10                  15      


Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn His Thr 
            20                  25                  30          


Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His Val Asp 
        35                  40                  45              


Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala Tyr Pro 
    50                  55                  60                  


Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp Asn Ser 
65                  70                  75                  80  


Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                85                  90              


<210>  32
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  32

Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser 
1               5                   10                  15      


Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu 
            20                  25                  30          


Ala Ser Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser 
        35                  40                  45              


Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln 
    50                  55                  60                  


Asn Val Asp Met Lys Ile Gly Val 
65                  70          


<210>  33
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  33

Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys Asn Leu Asp Glu 
1               5                   10                  15      


Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln Leu Met Asn Val 
            20                  25                  30          


Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr Lys Arg Lys Ile 
        35                  40                  45              


Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln Ser Ile Pro Arg 
    50                  55                  60                  


Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys Pro Phe Asn Gln 
65                  70                  75                  80  


Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp Tyr Asn Arg Val 
                85                  90                  95      


Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn Tyr Ile Asn Ala 
            100                 105                 110         


Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr Ile Ala Ala Gln 
        115                 120                 125             


Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg Met Ile Trp Glu 
    130                 135                 140                 


Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys Glu Glu Gly Asn 
145                 150                 155                 160 


Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu Glu Gly Thr Arg 
                165                 170                 175     


Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His Lys Arg Cys Pro 
            180                 185                 190         


Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys Lys Glu Lys Ala 
        195                 200                 205             


Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser Trp Pro Asp His 
    210                 215                 220                 


Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu Arg Arg Arg Val 
225                 230                 235                 240 


Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val Val His Cys Ser 
                245                 250                 255     


Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile Asp Ala Met Leu 
            260                 265                 270         


Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr Gly Tyr Val Val 
        275                 280                 285             


Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val Glu Ala Gln Tyr 
    290                 295                 300                 


Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln Phe Gly Glu Thr 
305                 310                 315                 320 


Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His Asn Met Lys Lys 
                325                 330                 335     


Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala Glu Phe Gln Arg 
            340                 345                 350         


Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile Gly Asn Gln Glu 
        355                 360                 365             


Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile Pro Tyr Asp Tyr 
    370                 375                 380                 


Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser Lys Glu Ser Glu 
385                 390                 395                 400 


His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp Ser Glu Glu Pro 
                405                 410                 415     


Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr Trp Lys Pro Glu 
            420                 425                 430         


Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr Ile Gly Asp Phe 
        435                 440                 445             


Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile Val Met Leu Thr 
    450                 455                 460                 


Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln Tyr Trp Gly Glu 
465                 470                 475                 480 


Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu Lys Asp Thr Asp 
                485                 490                 495     


Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu Arg His Ser Lys 
            500                 505                 510         


Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr Thr Asn Trp Ser 
        515                 520                 525             


Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile Ser Met Ile Gln 
    530                 535                 540                 


Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu Gly Asn Lys 
545                 550                 555                 560 


His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp Gly Ser Gln 
                565                 570                 575     


Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu Ser Ala Glu 
            580                 585                 590         


Thr Glu Glu Val Val Asp Ile Phe Gln Val Val Lys Ala Leu Arg Lys 
        595                 600                 605             


Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln Phe Leu Tyr 
    610                 615                 620                 


Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln Val Lys Lys 
625                 630                 635                 640 


Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu Val Asp Lys 
                645                 650                 655     


Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala Pro Glu Lys 
            660                 665                 670         


Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro Thr Ser Gly 
        675                 680                 685             


Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser Pro Ala Leu 
    690                 695                 700                 


Asn Gln Gly Ser 
705             


<210>  34
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  34

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  35
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu 
65                  70                  75                  80  


Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg 
                85                  90                  95      


Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser 
            100                 105                 110         


Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val 
        115                 120                 125             


Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe 
    130                 135                 140                 


Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys 
145                 150                 155                 160 


Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu 
                165                 170                 175     


Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro 
            180                 185                 190         


Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu 
        195                 200                 205             


Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp 
    210                 215                 220                 


Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr 
225                 230                 235                 240 


Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly 
                245                 250                 255     


Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala 
            260                 265                 270         


Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe 
        275                 280                 285             


Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg 
    290                 295                 300                 


Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp 
305                 310                 315                 320 


Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met 
                325                 330                 335     


Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn 
            340                 345                 350         


Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro 
        355                 360                 365             


Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu 
    370                 375                 380                 


Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu 
385                 390                 395                 400 


Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile 
                405                 410                 415     


Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly 
            420                 425                 430         


Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser 
        435                 440                 445             


Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val 
    450                 455                 460                 


Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly 
465                 470                 475                 480 


Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala Lys Arg Gly Arg Lys 
                485                 490                 495     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            500                 505                 510         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        515                 520                 525             


Gly Gly Cys Glu Leu 
    530             


<210>  36
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  36

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp 
65                  70                  75                  80  


Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly 
                85                  90                  95      


Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr 
            100                 105                 110         


Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser 
        115                 120                 125             


His Arg Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys 
    130                 135                 140                 


Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro 
145                 150                 155                 160 


Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala 
                165                 170                 175     


Glu Asn Ser Leu Ser Pro Ser Ser Asn Lys Arg Gly Arg Lys Lys Leu 
            180                 185                 190         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        195                 200                 205             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    210                 215                 220                 


Cys Glu Leu 
225         


<210>  37
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  37

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala 
65                  70                  75                  80  


Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys 
                85                  90                  95      


Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile Lys Arg Gly 
            100                 105                 110         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        115                 120                 125             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    130                 135                 140                 


Glu Glu Gly Gly Cys Glu Leu 
145                 150     


<210>  38
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  38

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys 
65                  70                  75                  80  


Gln Arg Gln Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe 
                85                  90                  95      


His Arg Asn His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr 
            100                 105                 110         


Ala Ser His Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His 
        115                 120                 125             


Leu Ser Ala Tyr Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met 
    130                 135                 140                 


Gln Pro Asp Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln 
145                 150                 155                 160 


Arg Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                165                 170                 175     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            180                 185                 190         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        195                 200                 


<210>  39
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  39

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val 
65                  70                  75                  80  


Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu 
                85                  90                  95      


Ser Ala Arg Tyr Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            100                 105                 110         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        115                 120                 125             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    130                 135                 140             


<210>  40
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  40

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Asn Ser Arg Arg Arg Cys Gly Gln Lys Lys Lys 
65                  70                  75                  80  


Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp Arg Lys Pro Ser 
                85                  90                  95      


Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met Val His Leu Val 
            100                 105                 110         


Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met Thr Ala Asp Glu 
        115                 120                 125             


Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly Val Lys Arg Gly 
    130                 135                 140                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
145                 150                 155                 160 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                165                 170                 175     


Glu Glu Gly Gly Cys Glu Leu 
            180             


<210>  41
<211>  819
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  41

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
65                  70                  75                  80  


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
                85                  90                  95      


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
            100                 105                 110         


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
        115                 120                 125             


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
    130                 135                 140                 


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
145                 150                 155                 160 


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
                165                 170                 175     


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
            180                 185                 190         


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
        195                 200                 205             


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
    210                 215                 220                 


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
225                 230                 235                 240 


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
                245                 250                 255     


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
            260                 265                 270         


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
        275                 280                 285             


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
    290                 295                 300                 


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
305                 310                 315                 320 


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
                325                 330                 335     


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
            340                 345                 350         


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
        355                 360                 365             


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
    370                 375                 380                 


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
385                 390                 395                 400 


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
                405                 410                 415     


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
            420                 425                 430         


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
        435                 440                 445             


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
    450                 455                 460                 


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
465                 470                 475                 480 


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
                485                 490                 495     


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
            500                 505                 510         


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
        515                 520                 525             


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
    530                 535                 540                 


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
545                 550                 555                 560 


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
                565                 570                 575     


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
            580                 585                 590         


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
        595                 600                 605             


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
    610                 615                 620                 


Ser Glu Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys 
625                 630                 635                 640 


Arg Asp Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu 
                645                 650                 655     


Leu Glu Ser Ala Glu Thr Glu Glu Val Val Asp Ile Phe Gln Val Val 
            660                 665                 670         


Lys Ala Leu Arg Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln 
        675                 680                 685             


Tyr Gln Phe Leu Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn 
    690                 695                 700                 


Gly Gln Val Lys Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp 
705                 710                 715                 720 


Asn Glu Val Asp Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu 
                725                 730                 735     


Gly Ala Pro Glu Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser 
            740                 745                 750         


Glu Pro Thr Ser Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro 
        755                 760                 765             


Ala Ser Pro Ala Leu Asn Gln Gly Ser Lys Arg Gly Arg Lys Lys Leu 
    770                 775                 780                 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
785                 790                 795                 800 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
                805                 810                 815     


Cys Glu Leu 
            


<210>  42
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  42

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys 
65                  70                  75                  80  


Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu 
                85                  90                  95      


Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe 
            100                 105                 110         


Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro 
        115                 120                 125             


Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln 
    130                 135                 140                 


Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr 
145                 150                 155                 160 


Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala 
                165                 170                 175     


Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser 
            180                 185                 190         


Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser 
        195                 200                 205             


Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr 
    210                 215                 220                 


Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu 
                245                 250                 255     


Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp 
            260                 265                 270         


Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp 
        275                 280                 285             


Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val 
    290                 295                 300                 


Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro 
305                 310                 315                 320 


Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn 
                325                 330                 335     


Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr 
            340                 345                 350         


His Leu Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        355                 360                 365             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    370                 375                 380                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395         


