               SEQUENCE LISTING

<110> Celon Pharma S.A., Uniwersytet Wrocławski

<120> Muteins of hFGF-1

<130> 17P46380PC00

<160> 38

<170> BiSSAP 1.3.6

<210> 1
<211> 155
<212> PRT
<213> Homo sapiens


<220> 
<223> FGF1 WT (1-155aa)

<400> 1
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 

<210> 2
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (22-155aa) - FGF1(Δ155aa) - FGF_ΔWT

<400> 2
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135     

<210> 3
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;S114A) (M1)

<400> 3
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ala Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 

<210> 4
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;L150D) (M2)

<400> 4
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Asp Pro Val Ser Ser Asp 
145                 150                 155 

<210> 5
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;S114A/L150D) (M3)

<400> 5
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ala Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Asp Pro Val Ser Ser Asp 
145                 150                 155 

<210> 6
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;Q55P) (M4)

<400> 6
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 

<210> 7
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;S62I) (M5)

<400> 7
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ile Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 

<210> 8
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;H108G) (M6)

<400> 8
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 

<210> 9
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;Q55P/S62I/H108G) (M7)

<400> 9
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 

<210> 10
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(155aa;Q55P/S62I/H108G/S114A/L150D) (M8)

<400> 10
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ala Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Asp Pro Val Ser Ser Asp 
145                 150                 155 

<210> 11
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155aa;S114A) (M9)

<400> 11
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ala Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135     

<210> 12
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155AA;L150D) (M10)

<400> 12
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Asp Pro Val Ser Ser Asp 
    130                 135     

<210> 13
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155aa;S114A/L150D) (M11)

<400> 13
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ala Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Asp Pro Val Ser Ser Asp 
    130                 135     

<210> 14
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155aa;Q55P) (M12)

<400> 14
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135     

<210> 15
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155aa;S62I) (M13)

<400> 15
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ile Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135     

<210> 16
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155aa;H108G) (M14)

<400> 16
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135     

<210> 17
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155aa;Q55P/S62I/H108G) (M15)

<400> 17
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135     

<210> 18
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1(Δ155aa;Q55P/S62I/H108G/S114A/L150D) (M16)

<400> 18
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr Ile Ala Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Asp Pro Val Ser Ser Asp 
    130                 135     

<210> 19
<211> 322
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_DIMER(155aa) (FGF1_WT_DIMER)

<400> 19
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Glu Gly Glu Ile Thr Thr 
                165                 170                 175     
Phe Thr Ala Leu Thr Glu Lys Phe Asn Leu Pro Pro Asn Tyr Lys Lys 
            180                 185                 190         
Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu 
        195                 200                 205             
Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile 
    210                 215                 220                 
Gln Leu Gln Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser 
225                 230                 235                 240 
Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr 
                245                 250                 255     
Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu 
            260                 265                 270         
Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn 
        275                 280                 285             
Trp Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg 
    290                 295                 300                 
Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser 
305                 310                 315                 320 
Ser Asp 
        

<210> 20
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_DIMER(Δ155aa) (FGF1_ΔWT_DIMER)

<400> 20
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ser Ser Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr 
145                 150                 155                 160 
Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val 
                165                 170                 175     
Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser 
            180                 185                 190         
Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln 
        195                 200                 205             
Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro 
    210                 215                 220                 
Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn 
225                 230                 235                 240 
Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu 
                245                 250                 255     
Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln 
            260                 265                 270         
Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
        275                 280                 285 

<210> 21
<211> 322
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M8_DIMER(155aa)

<400> 21
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ala Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Asp Pro Val Ser Ser Asp Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Glu Gly Glu Ile Thr Thr 
                165                 170                 175     
Phe Thr Ala Leu Thr Glu Lys Phe Asn Leu Pro Pro Asn Tyr Lys Lys 
            180                 185                 190         
Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu 
        195                 200                 205             
Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Pro His Ile 
    210                 215                 220                 
Gln Leu Gln Leu Ile Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser 
225                 230                 235                 240 
Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr 
                245                 250                 255     
Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu 
            260                 265                 270         
Glu Asn Gly Tyr Asn Thr Tyr Ile Ala Lys Lys His Ala Glu Lys Asn 
        275                 280                 285             
Trp Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg 
    290                 295                 300                 
Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Asp Pro Val Ser 
305                 310                 315                 320 
Ser Asp 
        

<210> 22
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M16_DIMER(Δ155aa)

<400> 22
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr Ile Ala Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Asp Pro Val Ser Ser Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr 
145                 150                 155                 160 
Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val 
                165                 170                 175     
Asp Gly Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile 
            180                 185                 190         
Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln 
        195                 200                 205             
Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro 
    210                 215                 220                 
Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn 
225                 230                 235                 240 
Thr Tyr Ile Ala Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu 
                245                 250                 255     
Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln 
            260                 265                 270         
Lys Ala Ile Leu Phe Leu Pro Asp Pro Val Ser Ser Asp 
        275                 280                 285 

<210> 23
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(155aa)

<400> 23
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ala Ser Asp 
145                 150                 155 

<210> 24
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(Δ155aa)

<400> 24
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ala Ser Asp 
    130                 135     

<210> 25
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(155aa)

<400> 25
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Arg Ser Asp 
145                 150                 155 

<210> 26
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(Δ155aa)

<400> 26
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Arg Ser Asp 
    130                 135     

<210> 27
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(155aa)

<400> 27
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Asp Asp Asp 
145                 150                 155 

<210> 28
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(Δ155aa)

<400> 28
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Asp Asp Asp 
    130                 135     

<210> 29
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(155aa)

<400> 29
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Asp Asp Asp 
145                 150                 155 

<210> 30
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1_M(Δ155aa)

<400> 30
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Pro His Ile Gln Leu Gln Leu Ile Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn Gly Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Asp Asp Asp 
    130                 135     

<210> 31
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (1-155aa) FGF1_M(155aa)

<400> 31
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Arg Ser Asp 
145                 150                 155 

<210> 32
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (22-155aa) FGF1_M(Δ155aa)

<400> 32
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ala Ser Asp 
145                 150                 155 

<210> 33
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (22-155aa) FGF1_M(Δ155aa)

<400> 33
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Arg Ser Asp 
    130                 135     

<210> 34
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (22-155aa) FGF1_M(Δ155aa)

<400> 34
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ala Ser Asp 
    130                 135     

<210> 35
<211> 322
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (1-155aa) FGF1_DIMER(155aa)

<400> 35
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Arg Ser Asp Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Glu Gly Glu Ile Thr Thr 
                165                 170                 175     
Phe Thr Ala Leu Thr Glu Lys Phe Asn Leu Pro Pro Asn Tyr Lys Lys 
            180                 185                 190         
Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu 
        195                 200                 205             
Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile 
    210                 215                 220                 
Gln Leu Gln Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser 
225                 230                 235                 240 
Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr 
                245                 250                 255     
Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu 
            260                 265                 270         
Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn 
        275                 280                 285             
Trp Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg 
    290                 295                 300                 
Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Arg 
305                 310                 315                 320 
Ser Asp 
        

<210> 36
<211> 322
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (1-155aa) FGF1_DIMER(155aa)

<400> 36
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      
Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          
Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              
Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  
Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  
Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      
Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         
Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             
Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 
Ile Leu Phe Leu Pro Leu Pro Val Ala Ser Asp Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Glu Gly Glu Ile Thr Thr 
                165                 170                 175     
Phe Thr Ala Leu Thr Glu Lys Phe Asn Leu Pro Pro Asn Tyr Lys Lys 
            180                 185                 190         
Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu 
        195                 200                 205             
Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile 
    210                 215                 220                 
Gln Leu Gln Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser 
225                 230                 235                 240 
Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr 
                245                 250                 255     
Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu 
            260                 265                 270         
Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn 
        275                 280                 285             
Trp Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg 
    290                 295                 300                 
Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ala 
305                 310                 315                 320 
Ser Asp 
        

<210> 37
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (22-155aa) FGF1_DIMER(Δ155aa)

<400> 37
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Arg Ser Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr 
145                 150                 155                 160 
Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val 
                165                 170                 175     
Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser 
            180                 185                 190         
Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln 
        195                 200                 205             
Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro 
    210                 215                 220                 
Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn 
225                 230                 235                 240 
Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu 
                245                 250                 255     
Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln 
            260                 265                 270         
Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Arg Ser Asp 
        275                 280                 285 

<210> 38
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> FGF1 (22-155aa) FGF1_DIMER(Δ155aa)

<400> 38
Met Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly 
1               5                   10                  15      
His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp 
            20                  25                  30          
Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly 
        35                  40                  45              
Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp 
    50                  55                  60                  
Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu 
65                  70                  75                  80  
Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys 
                85                  90                  95      
Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser 
            100                 105                 110         
Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe 
        115                 120                 125             
Leu Pro Leu Pro Val Ala Ser Asp Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ala Asn Tyr Lys Lys Pro Lys Leu Leu Tyr 
145                 150                 155                 160 
Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val 
                165                 170                 175     
Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser 
            180                 185                 190         
Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln 
        195                 200                 205             
Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro 
    210                 215                 220                 
Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn 
225                 230                 235                 240 
Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu 
                245                 250                 255     
Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln 
            260                 265                 270         
Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ala Ser Asp 
        275                 280                 285 

