                         SEQUENCE LISTING

<110>  Pfizer Inc.
 
<120>  Immunogenic compositions comprising conjugated capsular 
       saccharide antigens and uses thereof

<130>  PC72675A

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  "A class" CpG oligonucleotide

<400>  1
ggggacgacg tcgtgggggg g                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  "A class" CpG oligonucleotide

<400>  2
ggggacgacg tcgtgggggg g                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  "B class" CpG oligonucleotide

<400>  3
tcgtcgtttt tcggtgcttt t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  "B class" CpG oligonucleotide

<400>  4
tcgtcgtttt tcggtcgttt t                                                 21


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  "B class" CpG oligonucleotide

<400>  5
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  "B class" CpG oligonucleotide

<400>  6
tcgtcgtttc gtcgttttgt cgtt                                              24


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  "B class" CpG oligonucleotide

<400>  7
tcgtcgtttt gtcgtttttt tcga                                              24


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-Class oligonucleotide

<400>  8
tcgtcgtttt tcggtgcttt t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-Class oligonucleotide

<400>  9
tcgtcgtttt tcggtcgttt t                                                 21


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-Class oligonucleotide

<400>  10
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-Class oligonucleotide

<400>  11
tcgtcgtttc gtcgttttgt cgtt                                              24


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-Class oligonucleotide

<400>  12
tcgtcgtttt gtcgtttttt tcga                                              24


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  13
tcgcgtcgtt cggcgcgcgc cg                                                22


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  14
tcgtcgacgt tcggcgcgcg ccg                                               23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  15
tcggacgttc ggcgcgcgcc g                                                 21


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  16
tcggacgttc ggcgcgccg                                                    19


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  17
tcgcgtcgtt cggcgcgccg                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  18
tcgacgttcg gcgcgcgccg                                                   20


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  19
tcgacgttcg gcgcgccg                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  20
tcgcgtcgtt cggcgccg                                                     18


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  21
tcgcgacgtt cggcgcgcgc cg                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  22
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  23
tcgtcgtttt cggcggccgc cg                                                22


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  24
tcgtcgtttt acggcgccgt gccg                                              24


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C class CpG Oligonucleotide

<400>  25
tcgtcgtttt cggcgcgcgc cgt                                               23


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotides

<400>  26
tcgcgtcgtt cggcgcgcgc cg                                                22


<210>  27
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  27
tcgtcgacgt tcggcgcgcg ccg                                               23


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  28
tcggacgttc ggcgcgcgcc g                                                 21


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  29
tcggacgttc ggcgcgccg                                                    19


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  30
tcgcgtcgtt cggcgcgccg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  31
tcgacgttcg gcgcgcgccg                                                   20


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  32
tcgacgttcg gcgcgccg                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  33
tcgcgtcgtt cggcgccg                                                     18


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  34
tcgcgacgtt cggcgcgcgc cg                                                22


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  35
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  36
tcgtcgtttt cggcggccgc cg                                                22


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  37
tcgtcgtttt acggcgccgt gccg                                              24


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-Class oligonucleotide

<400>  38
tcgtcgtttt cggcgcgcgc cgt                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P class CpG oligonucleotide

<400>  39
tcgtcgacga tcggcgcgcg ccg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P class CpG oligonucleotide

<400>  40
tcgtcgacga tcggcgcgcg ccg                                               23


<210>  41
<211>  950
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically inactive fragment of SCP

<400>  41

Met Ala Lys Thr Ala Asp Thr Pro Ala Thr Ser Lys Ala Thr Ile Arg 
1               5                   10                  15      


Asp Leu Asn Asp Pro Ser Gln Val Lys Thr Leu Gln Glu Lys Ala Gly 
            20                  25                  30          


Lys Gly Ala Gly Thr Val Val Ala Val Ile Ala Ala Gly Phe Asp Lys 
        35                  40                  45              


Asn His Glu Ala Trp Arg Leu Thr Asp Lys Ala Lys Ala Arg Tyr Gln 
    50                  55                  60                  


Ser Lys Glu Asp Leu Glu Lys Ala Lys Lys Glu His Gly Ile Thr Tyr 
65                  70                  75                  80  


Gly Glu Trp Val Asn Asp Lys Val Ala Tyr Tyr His Asp Tyr Ser Lys 
                85                  90                  95      


Asp Gly Lys Thr Ala Val Asp Gln Glu His Gly Thr His Val Ser Gly 
            100                 105                 110         


Ile Leu Ser Gly Asn Ala Pro Ser Glu Thr Lys Glu Pro Tyr Arg Leu 
        115                 120                 125             


Glu Gly Ala Met Pro Glu Ala Gln Leu Leu Leu Met Arg Val Glu Ile 
    130                 135                 140                 


Val Asn Gly Leu Ala Asp Tyr Ala Arg Asn Tyr Ala Gln Ala Ile Arg 
145                 150                 155                 160 


Asp Ala Ile Asn Leu Gly Ala Lys Val Ile Asn Met Ser Phe Gly Asn 
                165                 170                 175     


Ala Ala Leu Ala Tyr Ala Asn Leu Pro Asp Glu Thr Lys Lys Ala Phe 
            180                 185                 190         


Asp Tyr Ala Lys Ser Lys Gly Val Ser Ile Val Thr Ser Ala Gly Asn 
        195                 200                 205             


Asp Ser Ser Phe Gly Gly Lys Thr Arg Leu Pro Leu Ala Asp His Pro 
    210                 215                 220                 


Asp Tyr Gly Val Val Gly Thr Pro Ala Ala Ala Asp Ser Thr Leu Thr 
225                 230                 235                 240 


Val Ala Ser Tyr Ser Pro Asp Lys Gln Leu Thr Glu Thr Val Thr Val 
                245                 250                 255     


Lys Thr Ala Asp Gln Gln Asp Lys Glu Met Pro Val Leu Ser Thr Asn 
            260                 265                 270         


Arg Phe Glu Pro Asn Lys Ala Tyr Asp Tyr Ala Tyr Ala Asn Arg Gly 
        275                 280                 285             


Thr Lys Glu Asp Asp Phe Lys Asp Val Lys Gly Lys Ile Ala Leu Ile 
    290                 295                 300                 


Glu Arg Gly Asp Ile Asp Phe Lys Asp Lys Ile Ala Lys Ala Lys Lys 
305                 310                 315                 320 


Ala Gly Ala Val Gly Val Leu Ile Tyr Asp Asn Gln Asp Lys Gly Phe 
                325                 330                 335     


Pro Ile Glu Leu Pro Asn Val Asp Gln Met Pro Ala Ala Phe Ile Ser 
            340                 345                 350         


Arg Lys Asp Gly Leu Leu Leu Lys Asp Asn Pro Gln Lys Thr Ile Thr 
        355                 360                 365             


Phe Asn Ala Thr Pro Lys Val Leu Pro Thr Ala Ser Gly Thr Lys Leu 
    370                 375                 380                 


Ser Arg Phe Ser Ser Trp Gly Leu Thr Ala Asp Gly Asn Ile Lys Pro 
385                 390                 395                 400 


Asp Ile Ala Ala Pro Gly Gln Asp Ile Leu Ser Ser Val Ala Asn Asn 
                405                 410                 415     


Lys Tyr Ala Lys Leu Ser Gly Thr Ala Met Ser Ala Pro Leu Val Ala 
            420                 425                 430         


Gly Ile Met Gly Leu Leu Gln Glu Gln Tyr Glu Thr Gln Tyr Pro Asp 
        435                 440                 445             


Met Thr Pro Ser Glu Arg Leu Asp Leu Ala Lys Lys Val Leu Met Ser 
    450                 455                 460                 


Ser Ala Thr Ala Leu Tyr Asp Glu Asp Glu Lys Ala Tyr Phe Ser Pro 
465                 470                 475                 480 


Arg Gln Gln Gly Ala Gly Ala Val Asp Ala Lys Lys Ala Ser Ala Ala 
                485                 490                 495     


Thr Met Tyr Val Thr Asp Lys Asp Asn Thr Ser Ser Lys Val His Leu 
            500                 505                 510         


Asn Asn Val Ser Asp Lys Phe Glu Val Thr Val Thr Val His Asn Lys 
        515                 520                 525             


Ser Asp Lys Pro Gln Glu Leu Tyr Tyr Gln Ala Thr Val Gln Thr Asp 
    530                 535                 540                 


Lys Val Asp Gly Lys His Phe Ala Leu Ala Pro Lys Ala Leu Tyr Glu 
545                 550                 555                 560 


Thr Ser Trp Gln Lys Ile Thr Ile Pro Ala Asn Ser Ser Lys Gln Val 
                565                 570                 575     


Thr Val Pro Ile Asp Ala Ser Arg Phe Ser Lys Asp Leu Leu Ala Gln 
            580                 585                 590         


Met Lys Asn Gly Tyr Phe Leu Glu Gly Phe Val Arg Phe Lys Gln Asp 
        595                 600                 605             


Pro Lys Lys Glu Glu Leu Met Ser Ile Pro Tyr Ile Gly Phe Arg Gly 
    610                 615                 620                 


Asp Phe Gly Asn Leu Ser Ala Leu Glu Lys Pro Ile Tyr Asp Ser Lys 
625                 630                 635                 640 


Asp Gly Ser Ser Tyr Tyr His Glu Ala Asn Ser Asp Ala Lys Asp Gln 
                645                 650                 655     


Leu Asp Gly Asp Gly Leu Gln Phe Tyr Ala Leu Lys Asn Asn Phe Thr 
            660                 665                 670         


Ala Leu Thr Thr Glu Ser Asn Pro Trp Thr Ile Ile Lys Ala Val Lys 
        675                 680                 685             


Glu Gly Val Glu Asn Ile Glu Asp Ile Glu Ser Ser Glu Ile Thr Glu 
    690                 695                 700                 


Thr Ile Phe Ala Gly Thr Phe Ala Lys Gln Asp Asp Asp Ser His Tyr 
705                 710                 715                 720 


Tyr Ile His Arg His Ala Asn Gly Lys Pro Tyr Ala Ala Ile Ser Pro 
                725                 730                 735     


Asn Gly Asp Gly Asn Arg Asp Tyr Val Gln Phe Gln Gly Thr Phe Leu 
            740                 745                 750         


Arg Asn Ala Lys Asn Leu Val Ala Glu Val Leu Asp Lys Glu Gly Asn 
        755                 760                 765             


Val Val Trp Thr Ser Glu Val Thr Glu Gln Val Val Lys Asn Tyr Asn 
    770                 775                 780                 


Asn Asp Leu Ala Ser Thr Leu Gly Ser Thr Arg Phe Glu Lys Thr Arg 
785                 790                 795                 800 


Trp Asp Gly Lys Asp Lys Asp Gly Lys Val Val Ala Asn Gly Thr Tyr 
                805                 810                 815     


Thr Tyr Arg Val Arg Tyr Thr Pro Ile Ser Ser Gly Ala Lys Glu Gln 
            820                 825                 830         


His Thr Asp Phe Asp Val Ile Val Asp Asn Thr Thr Pro Glu Val Ala 
        835                 840                 845             


Thr Ser Ala Thr Phe Ser Thr Glu Asp Arg Arg Leu Thr Leu Ala Ser 
    850                 855                 860                 


Lys Pro Lys Thr Ser Gln Pro Val Tyr Arg Glu Arg Ile Ala Tyr Thr 
865                 870                 875                 880 


Tyr Met Asp Glu Asp Leu Pro Thr Thr Glu Tyr Ile Ser Pro Asn Glu 
                885                 890                 895     


Asp Gly Thr Phe Thr Leu Pro Glu Glu Ala Glu Thr Met Glu Gly Ala 
            900                 905                 910         


Thr Val Pro Leu Lys Met Ser Asp Phe Thr Tyr Val Val Glu Asp Met 
        915                 920                 925             


Ala Gly Asn Ile Thr Tyr Thr Pro Val Thr Lys Leu Leu Glu Gly His 
    930                 935                 940                 


Ser Asn Lys Pro Glu Gln 
945                 950 


<210>  42
<211>  949
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzymatically inactive fragment of SCP

<400>  42

Ala Lys Thr Ala Asp Thr Pro Ala Thr Ser Lys Ala Thr Ile Arg Asp 
1               5                   10                  15      


Leu Asn Asp Pro Ser Gln Val Lys Thr Leu Gln Glu Lys Ala Gly Lys 
            20                  25                  30          


Gly Ala Gly Thr Val Val Ala Val Ile Ala Ala Gly Phe Asp Lys Asn 
        35                  40                  45              


His Glu Ala Trp Arg Leu Thr Asp Lys Ala Lys Ala Arg Tyr Gln Ser 
    50                  55                  60                  


Lys Glu Asp Leu Glu Lys Ala Lys Lys Glu His Gly Ile Thr Tyr Gly 
65                  70                  75                  80  


Glu Trp Val Asn Asp Lys Val Ala Tyr Tyr His Asp Tyr Ser Lys Asp 
                85                  90                  95      


Gly Lys Thr Ala Val Asp Gln Glu His Gly Thr His Val Ser Gly Ile 
            100                 105                 110         


Leu Ser Gly Asn Ala Pro Ser Glu Thr Lys Glu Pro Tyr Arg Leu Glu 
        115                 120                 125             


Gly Ala Met Pro Glu Ala Gln Leu Leu Leu Met Arg Val Glu Ile Val 
    130                 135                 140                 


Asn Gly Leu Ala Asp Tyr Ala Arg Asn Tyr Ala Gln Ala Ile Arg Asp 
145                 150                 155                 160 


Ala Ile Asn Leu Gly Ala Lys Val Ile Asn Met Ser Phe Gly Asn Ala 
                165                 170                 175     


Ala Leu Ala Tyr Ala Asn Leu Pro Asp Glu Thr Lys Lys Ala Phe Asp 
            180                 185                 190         


Tyr Ala Lys Ser Lys Gly Val Ser Ile Val Thr Ser Ala Gly Asn Asp 
        195                 200                 205             


Ser Ser Phe Gly Gly Lys Thr Arg Leu Pro Leu Ala Asp His Pro Asp 
    210                 215                 220                 


Tyr Gly Val Val Gly Thr Pro Ala Ala Ala Asp Ser Thr Leu Thr Val 
225                 230                 235                 240 


Ala Ser Tyr Ser Pro Asp Lys Gln Leu Thr Glu Thr Val Thr Val Lys 
                245                 250                 255     


Thr Ala Asp Gln Gln Asp Lys Glu Met Pro Val Leu Ser Thr Asn Arg 
            260                 265                 270         


Phe Glu Pro Asn Lys Ala Tyr Asp Tyr Ala Tyr Ala Asn Arg Gly Thr 
        275                 280                 285             


Lys Glu Asp Asp Phe Lys Asp Val Lys Gly Lys Ile Ala Leu Ile Glu 
    290                 295                 300                 


Arg Gly Asp Ile Asp Phe Lys Asp Lys Ile Ala Lys Ala Lys Lys Ala 
305                 310                 315                 320 


Gly Ala Val Gly Val Leu Ile Tyr Asp Asn Gln Asp Lys Gly Phe Pro 
                325                 330                 335     


Ile Glu Leu Pro Asn Val Asp Gln Met Pro Ala Ala Phe Ile Ser Arg 
            340                 345                 350         


Lys Asp Gly Leu Leu Leu Lys Asp Asn Pro Gln Lys Thr Ile Thr Phe 
        355                 360                 365             


Asn Ala Thr Pro Lys Val Leu Pro Thr Ala Ser Gly Thr Lys Leu Ser 
    370                 375                 380                 


Arg Phe Ser Ser Trp Gly Leu Thr Ala Asp Gly Asn Ile Lys Pro Asp 
385                 390                 395                 400 


Ile Ala Ala Pro Gly Gln Asp Ile Leu Ser Ser Val Ala Asn Asn Lys 
                405                 410                 415     


Tyr Ala Lys Leu Ser Gly Thr Ala Met Ser Ala Pro Leu Val Ala Gly 
            420                 425                 430         


Ile Met Gly Leu Leu Gln Glu Gln Tyr Glu Thr Gln Tyr Pro Asp Met 
        435                 440                 445             


Thr Pro Ser Glu Arg Leu Asp Leu Ala Lys Lys Val Leu Met Ser Ser 
    450                 455                 460                 


Ala Thr Ala Leu Tyr Asp Glu Asp Glu Lys Ala Tyr Phe Ser Pro Arg 
465                 470                 475                 480 


Gln Gln Gly Ala Gly Ala Val Asp Ala Lys Lys Ala Ser Ala Ala Thr 
                485                 490                 495     


Met Tyr Val Thr Asp Lys Asp Asn Thr Ser Ser Lys Val His Leu Asn 
            500                 505                 510         


Asn Val Ser Asp Lys Phe Glu Val Thr Val Thr Val His Asn Lys Ser 
        515                 520                 525             


Asp Lys Pro Gln Glu Leu Tyr Tyr Gln Ala Thr Val Gln Thr Asp Lys 
    530                 535                 540                 


Val Asp Gly Lys His Phe Ala Leu Ala Pro Lys Ala Leu Tyr Glu Thr 
545                 550                 555                 560 


Ser Trp Gln Lys Ile Thr Ile Pro Ala Asn Ser Ser Lys Gln Val Thr 
                565                 570                 575     


Val Pro Ile Asp Ala Ser Arg Phe Ser Lys Asp Leu Leu Ala Gln Met 
            580                 585                 590         


Lys Asn Gly Tyr Phe Leu Glu Gly Phe Val Arg Phe Lys Gln Asp Pro 
        595                 600                 605             


Lys Lys Glu Glu Leu Met Ser Ile Pro Tyr Ile Gly Phe Arg Gly Asp 
    610                 615                 620                 


Phe Gly Asn Leu Ser Ala Leu Glu Lys Pro Ile Tyr Asp Ser Lys Asp 
625                 630                 635                 640 


Gly Ser Ser Tyr Tyr His Glu Ala Asn Ser Asp Ala Lys Asp Gln Leu 
                645                 650                 655     


Asp Gly Asp Gly Leu Gln Phe Tyr Ala Leu Lys Asn Asn Phe Thr Ala 
            660                 665                 670         


Leu Thr Thr Glu Ser Asn Pro Trp Thr Ile Ile Lys Ala Val Lys Glu 
        675                 680                 685             


Gly Val Glu Asn Ile Glu Asp Ile Glu Ser Ser Glu Ile Thr Glu Thr 
    690                 695                 700                 


Ile Phe Ala Gly Thr Phe Ala Lys Gln Asp Asp Asp Ser His Tyr Tyr 
705                 710                 715                 720 


Ile His Arg His Ala Asn Gly Lys Pro Tyr Ala Ala Ile Ser Pro Asn 
                725                 730                 735     


Gly Asp Gly Asn Arg Asp Tyr Val Gln Phe Gln Gly Thr Phe Leu Arg 
            740                 745                 750         


Asn Ala Lys Asn Leu Val Ala Glu Val Leu Asp Lys Glu Gly Asn Val 
        755                 760                 765             


Val Trp Thr Ser Glu Val Thr Glu Gln Val Val Lys Asn Tyr Asn Asn 
    770                 775                 780                 


Asp Leu Ala Ser Thr Leu Gly Ser Thr Arg Phe Glu Lys Thr Arg Trp 
785                 790                 795                 800 


Asp Gly Lys Asp Lys Asp Gly Lys Val Val Ala Asn Gly Thr Tyr Thr 
                805                 810                 815     


Tyr Arg Val Arg Tyr Thr Pro Ile Ser Ser Gly Ala Lys Glu Gln His 
            820                 825                 830         


Thr Asp Phe Asp Val Ile Val Asp Asn Thr Thr Pro Glu Val Ala Thr 
        835                 840                 845             


Ser Ala Thr Phe Ser Thr Glu Asp Arg Arg Leu Thr Leu Ala Ser Lys 
    850                 855                 860                 


Pro Lys Thr Ser Gln Pro Val Tyr Arg Glu Arg Ile Ala Tyr Thr Tyr 
865                 870                 875                 880 


Met Asp Glu Asp Leu Pro Thr Thr Glu Tyr Ile Ser Pro Asn Glu Asp 
                885                 890                 895     


Gly Thr Phe Thr Leu Pro Glu Glu Ala Glu Thr Met Glu Gly Ala Thr 
            900                 905                 910         


Val Pro Leu Lys Met Ser Asp Phe Thr Tyr Val Val Glu Asp Met Ala 
        915                 920                 925             


Gly Asn Ile Thr Tyr Thr Pro Val Thr Lys Leu Leu Glu Gly His Ser 
    930                 935                 940                 


Asn Lys Pro Glu Gln 
945                 


