                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> NOVEL BICYCLIC COMPOUNDS AND THEIR USES

<130> PAT059096

<140>
<141>

<150> PCT/CN2022/085537
<151> 2022-04-07

<150> PCT/CN2021/096104
<151> 2021-05-26

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 9674
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa       60

cctataaata ttccggatta ttcataccgt cccaccatcg ggcgccatgg cttctcacca      120

ccatcaccat caccatcatc atcacgctca gcacgacgag gctgtggaca acaagttcaa      180

caaggagcag cagaacgctt tctacgagat cctgcacctc cctaacctga acgaggagca      240

gcgtaacgct ttcatccagt ccctgaagga cgacccttct cagtctgcta acctgctggc      300

tgaggctaag aagctgaacg acgctcaggc tcctaaggtg gacaacaagt tcaacaagga      360

gcagcagaac gctttctacg agatcctgca cctccctaac ctgaacgagg agcagcgtaa      420

cgctttcatc cagtccctga aggacgaccc ttctcagtct gctaacctgc tggctgaggc      480

taagaagctg aacgacgctc aggctcctaa ggtggacgct aacggtggcg gcggttccgg      540

cggtggtggc tctctcgagg ttctgttcca gggtccgaat gaaggcgagg aagatgatga      600

caaagacttc ctgtggccag ctccaaacga agaacaggtg acttgtctca agatgtactt      660

cggtcatagc agcttcaaac cagtgcagtg gaaagttatc cacagcgttc ttgaagaacg      720

tcgtgataat gtggctgtga tggctactgg ctatggtaag agcctgtgtt tccagtaccc      780

gccagtttac gttggtaaga tcggtctggt gattagcccg ctgatctctc tgatggaaga      840

ccaggtgctg caacttaaga tgagcaacat cccggcttgt ttcctgggtt ctgcacaaag      900

cgagaacgtg ctcaccgata tcaagctggg taagtaccgt atcgtgtacg tgacgccaga      960

atactgtagc ggcaacatgg gtcttctgca acagctcgaa gctgatattg gcatcaccct     1020

cattgcagtg gacgaagctc actgtatcag cgagtggggt catgatttcc gcgactcttt     1080

ccgtaaactg ggttctctga agactgcact tccgatggtt ccaattgtgg cactgaccgc     1140

aactgcttct agctctattc gtgaagacat cgttcgttgc ctgaacctcc gtaacccaca     1200

aattacctgc accggctttg accgtccgaa cctgtacctg gaggttcgtc gtaagaccgg     1260

taatatcctt caggacctgc aaccattcct ggttaagacc agcagccact gggagttcga     1320

aggtccgact atcatctact gcccaagccg taagatgacc cagcaggtta ctggtgaact     1380

gcgtaaactg aacctgagct gtggcactta ccacgcaggc atgtctttct ctacccgtaa     1440

agacatccat catcgtttcg tgcgtgatga aatccagtgc gttatcgcta ccattgcatt     1500

cggcatgggt atcaacaaag ctgacatccg tcaagtgatt cactacggtg caccgaaaga     1560

catggaaagc tactaccagg aaatcggccg tgcaggtcgt gatggtctgc aaagctcttg     1620

tcatgtgctg tgggcaccag cagatattaa cctgaaccgt cacctgctga ctgaaattcg     1680

taacgagaaa ttccgtctgt acaaactgaa gatgatggcg aagatggaga aatacctgca     1740

tagctcccgt tgtcgtcgtc aaatcattct gagccatttc gaggataaac aggtgcagaa     1800

agcttctctg ggtatcatgg gcactgagaa gtgctgcgat aactgtcgta gccgtcttga     1860

tcactgctac agcatggacg atagcgaaga cacttcttgg gatttcggtc cacaagcatt     1920

caaactgctg agcgcagttg atatcctggg tgagaaattc ggcatcggcc tcccaatcct     1980

gtttctgcgc ggttctaact ctcagcgtct tgctgatcaa taccgtcgtc actctctgtt     2040

cggcactggt aaagaccaga ccgaatcttg gtggaaagca ttcagccgtc aacttatcac     2100

cgaaggcttt ctggtggaag tgtctcgtta caacaagttc atgaagatct gcgcactgac     2160

taagaaaggt cgtaactggc tgcacaaggc aaataccgag tctcagtctc ttatccttca     2220

ggctaacgaa gaactgtgcc cgaagaagct tctgctgcca tcttctaaga ccgtgagctc     2280

tggtactaaa gagcattgct acaaccaggt gccggttgaa ctgtctaccg agaagaagtc     2340

caacctggag aagctgtact cctacaaacc gtgcgacaag atctcctccg gttctaatat     2400

cagcaagaag tccatcatgg tgcagtctcc ggagaaagct tacagcagct ctcagccagt     2460

tatctctgca caggaacagg aaactcagat tgtgctgtac ggtaaactgg tggaagcacg     2520

tcagaaacac gctaacaaga tggacgtgcc gccagcaatt cttgcaacca acaagattct     2580

ggtggacatg gctaagatgc gcccaactac tgttgagaac gtgaaacgta tcgacggtgt     2640

tagcgaaggt aaagctgcaa tgctggcacc actgcttgaa gttatcaagc atttctgcca     2700

gaccaactct gttcagaccg acctgttctc ttctaccaaa ccataatggt accgaattcg     2760

cggccgcaga gctcgctctg gtgccacgcg gtagttccgc ttggagccac ccgcagttcg     2820

aaaagtaagt gattaacctc aggttataca tatattttga atttaattaa ttatacatat     2880

attttatatt atttttgtct tttattatcg aggggccgtt gttggtgtgg ggttttgcat     2940

agaaataaca atgggagttg gcgacgttgc tgcgccaaca ccacctccct tccctccttt     3000

catcatgtat ctgtagataa aataaaatat taaacctaaa aacaagaccg cgcctatcaa     3060

caaaatgata ggcattaact tgccgctgac gctgtcacta acgttggacg atttgccgac     3120

taaaccttca tcgcccagta accaatctag gtagctgagc gcatgcaagc tgatccgggt     3180

tattagtaca tttattaagc gctagattct gtgcgttgtt gatttacaga caattgttgt     3240

acgtatttta ataattcatt aaatttataa tctttagggt ggtatgttag agcgaaaatc     3300

aaatgatttt cagcgtcttt atatctgaat ttaaatatta aatcctcaat agatttgtaa     3360

aataggtttc gattagtttc aaacaagggt tgtttttccg aaccgatggc tggactatct     3420

aatggatttt cgctcaacgc cacaaaactt gccaaatctt gtagcagcaa tctagctttg     3480

tcgatattcg tttgtgtttt gttttgtaat aaaggttcga cgtcgttcaa aatattatgc     3540

gcttttgtat ttctttcatc actgtcgtta gtgtacaatt gactcgacgt aaacacgtta     3600

aatagagctt ggacatattt aacatcgggc gtgttagctt tattaggccg attatcgtcg     3660

tcgtcccaac cctcgtcgtt agaagttgct tccgaagacg attttgccat agccacacga     3720

cgcctattaa ttgtgtcggc taacacgtcc gcgatcaaat ttgtagttga gctttttgga     3780

attatttctg attgcgggcg tttttgggcg ggtttcaatc taactgtgcc cgattttaat     3840

tcagacaaca cgttagaaag cgatggtgca ggcggtggta acatttcaga cggcaaatct     3900

actaatggcg gcggtggtgg agctgatgat aaatctacca tcggtggagg cgcaggcggg     3960

gctggcggcg gaggcggagg cggaggtggt ggcggtgatg cagacggcgg tttaggctca     4020

aatgtctctt taggcaacac agtcggcacc tcaactattg tactggtttc gggcgccgtt     4080

tttggtttga ccggtctaag acgagtgcga tttttttcgt ttctaatagc ttccaacaat     4140

tgttgtctgt cgtctaaagg tgcagcgggt tgaggttccg tcggcattgg tggagcgggc     4200

ggcaattcag acatcgatgg tggtggtggt ggtggaggcg ctggaatgtt aggcacggga     4260

gaaggtggtg gcggcggtgc cgccggtata atttgttctg gtttagtttg ttcgcgcacg     4320

attgtgggca ccggcgcagg cgccgctggc tgcacaacgg aaggtcgtct gcttcgaggc     4380

agcgcttggg gtggtggcaa ttcaatatta taattggaat acaaatcgta aaaatctgct     4440

ataagcattg taatttcgct atcgtttacc gtgccgatat ttaacaaccg ctcaatgtaa     4500

gcaattgtat tgtaaagaga ttgtctcaag ctcggatcga tcccgcacgc cgataacaag     4560

ccttttcatt tttactacag cattgtagtg gcgagacact tcgctgtcgt cgaggtttaa     4620

acgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag     4680

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca     4740

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt     4800

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc     4860

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct     4920

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg     4980

tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca     5040

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact     5100

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta     5160

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta     5220

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct     5280

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt     5340

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     5400

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     5460

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     5520

caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg     5580

cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt     5640

agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag     5700

acccacgctc accggctcca gatttatcag caataaacca gccagccgga agggccgagc     5760

gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag     5820

ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca     5880

tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa     5940

ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga     6000

tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata     6060

attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca     6120

agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg     6180

ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg     6240

ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg     6300

cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag     6360

gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac     6420

tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca     6480

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     6540

tgccacctga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca     6600

gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct     6660

ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt     6720

tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac     6780

gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct     6840

ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt     6900

ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac     6960

aaaaatttaa cgcgaatttt aacaaaatat taacgtttac aatttcccat tcgccattca     7020

ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc ttcgctatta cgccaggaac     7080

ggctccgccc actattaatg aaattaaaaa ttccaatttt aaaaaacgca gcaagagaaa     7140

catttgtatg aaagaatgcg tagaaggaaa gaaaaatgtc gtcgacatgc tgaacaacaa     7200

gattaatatg cctccgtgta taaaaaaaat attgaacgat ttgaaagaaa acaatgtacc     7260

gcgcggcggt atgtacagga agaggtttat actaaactgt tacattgcaa acgtggtttc     7320

gtgtgccaag tgtgaaaacc gatgtttaat caaggctctg acgcatttct acaaccacga     7380

ctccaagtgt gtgggtgaag tcatgcatct tttaatcaaa tcccaagatg tgtataaacc     7440

accaaactgc caaaaaatga aaactgtcga caagctctgt ccgtttgctg gcaactgcaa     7500

gggtctcaat cctatttgta attattgaat aataaaacaa ttataaatgc taaatttgtt     7560

ttttattaac gatacaaacc aaacgcaaca agaacatttg tagtattatc tataattgaa     7620

aacgcgtagt tataatcgct gaggtaatat ttaaaatcat tttcaaatga ttcacagtta     7680

atttgcgaca atataatttt attttcacat aaactagacg ccttgtcgtc ttcttcttcg     7740

tattccttct ctttttcatt tttctcttca taaaaattaa catagttatt atcgtatcca     7800

tatatgtatc tatcgtatag agtaaatttt ttgttgtcat aaatatatat gtctttttta     7860

atggggtgta tagtaccgct gcgcatagtt tttctgtaat ttacaacagt gctattttct     7920

ggtagttctt cggagtgtgt tgctttaatt attaaattta tataatcaat gaatttggga     7980

tcgtcggttt tgtacaatat gttgccggca tagtacgcag cttcttctag ttcaattaca     8040

ccatttttta gcagcaccgg attaacataa ctttccaaaa tgttgtacga accgttaaac     8100

aaaaacagtt cacctccctt ttctatacta ttgtctgcga gcagttgttt gttgttaaaa     8160

ataacagcca ttgtaataag acgcacaaac taatatcaca aactggaaat gtctatcaat     8220

atatagttgc tgatcagatc tacccgtagt ggctatggca gggcttgccg ccccgacgtt     8280

ggctgcgagc cctgggcctt cacccgaact tgggggttgg ggtggggaaa aggaagaaac     8340

gcgggcgtat tggtcccaat ggggtctcgg tggggtatcg acagagtgcc agccctggga     8400

ccgaaccccg cgtttatgaa caaacgaccc aacacccgtg cgttttattc tgtcttttta     8460

ttgccgtcat agcgcgggtt ccttccggta ttgtctcctt ccgtgtttca gttagcctcc     8520

cccatctccc ggtaccgcat gctatgcatc ggccgcttta cttgtacagc tcgtccatgc     8580

cgagagtgat cccggcggcg gtcacgaact ccagcaggac catgtgatcg cgcttctcgt     8640

tggggtcttt gctcagggcg gactgggtgc tcaggtagtg gttgtcgggc agcagcacgg     8700

ggccgtcgcc gatgggggtg ttctgctggt agtggtcggc gagctgcacg ctgccgtcct     8760

cgatgttgtg gcggatcttg aagttcacct tgatgccgtt cttctgcttg tcggccatga     8820

tatagacgtt gtggctgttg tagttgtact ccagcttgtg ccccaggatg ttgccgtcct     8880

ccttgaagtc gatgcccttc agctcgatgc ggttcaccag ggtgtcgccc tcgaacttca     8940

cctcggcgcg ggtcttgtag ttgccgtcgt ccttgaagaa gatggtgcgc tcctggacgt     9000

agccttcggg catggcggac ttgaagaagt cgtgctgctt catgtggtcg gggtagcggc     9060

tgaagcactg cacgccgtag gtcagggtgg tcacgagggt gggccagggc acgggcagct     9120

tgccggtggt gcagatgaac ttcagggtca gcttgccgta ggtggcatcg ccctcgccct     9180

cgccggacac gctgaacttg tggccgttta cgtcgccgtc cagctcgacc aggatgggca     9240

ccaccccggt gaacagctcc tcgcccttgc tcaccatcgt cgagatcccg ggcgtttaaa     9300

ttgtgtaatt tatgtagctg taatttttac cttattaata ttttttacgc tttgcattcg     9360

acgactgaac tcccaaatat atgtttaact cgtcttggtc gtttgaattt ttgttgctgt     9420

gtttcctaat attttccatc accttaaata tgttattgta atcctcaatg ttgaacttgc     9480

aattggacac ggcatagttt tccatagtcg tgtaaaacat ggtattggct gcattgtaat     9540

acatccgact gagcgggtac ggatctatgt gtttgagcag cctgttcaaa aactctgcat     9600

cgtcgcaaaa cggaatttgg tacccgggcg tatactccgg aatattaata gatcatggag     9660

ataattaaaa tgat                                                       9674


<210> 2
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
tttttttttt tttttttttt ttccaagtaa aacgacggcc agtgc                       45


<210> 3
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Ala Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210> 4
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 5
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210> 6
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Val Ile Tyr Ala Asp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ala Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val 
1               5                   10          


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Lys Ser Ser Glu Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Tyr Ala Phe His Arg Phe Thr 
1               5           


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
His Gln Ala Tyr Ser Ser Pro Tyr Thr 
1               5                   


