                         SEQUENCE LISTING

<110>  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES 
       ALTERNATIVES
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
 
<120>  APTAMERES ARN SPECIFIQUES DE CONFORMERES DE FIBRES DE LA PROTEINE A-SYNUCLEINE

<130>  B381551PCT D41159

<150>  FR 2105529
<151>  2021-05-27

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N30

<400>  1
ucgauccacg uccgacaacg cguuuacucg ccauc                                  35


<210>  2
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N124

<400>  2
uccgaccaug cuucaacuua uaccucgggg acugu                                  35


<210>  3
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N3

<400>  3
caacgcguuu accucacacc acgucauccg uugcc                                  35


<210>  4
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre 4F02

<400>  4
gcuggcagca cgcaccgcug accgcuggcu gcacuaugcg uguggagugc                  50


<210>  5
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre 4F03

<400>  5
gcaacagacg caccguacac acaucuuggc cguuggcugc ccgaccagcc                  50


<210>  6
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre F124

<400>  6
cacggacacc uacccgacgg caugucagga cacauguugu gcuccgugug                  50


<210>  7
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre P65

<400>  7
cgcacagugu acaccuacac acagcauacc uguuggcauc ccagguugcc                  50


<210>  8
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N0

<400>  8
ucaguccagu acgagacgcg uuuaccucca cugca                                  35


<210>  9
<211>  34
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N1

<400>  9
auccgaccaa cccaacgcgu uuaccucacc ugca                                   34


<210>  10
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N2

<400>  10
uuccgaccgc cgcaacuuau agguaucccg cugca                                  35


<210>  11
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N4

<400>  11
acgcguuuac uccgcuagua cgaacccgau ugccc                                  35


<210>  12
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N5

<400>  12
agccaugcug ucaacuuuua acucgucacc gcucg                                  35


<210>  13
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N15

<400>  13
aucggccaca gucgacaacu uugaaaucca ccugc                                  35


<210>  14
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N20

<400>  14
gcagcacaug accucaccuu uuacucugcg cugca                                  35


<210>  15
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N37

<400>  15
ucaguccagc accaacgccg uuugcucucg acuac                                  35


<210>  16
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N62

<400>  16
guuuccgaac ggcccaacuu ugaaaucccc gcccg                                  35


<210>  17
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N73

<400>  17
caacuugaaa ucccaacccu gcagccgugu cuggu                                  35


<210>  18
<211>  35
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre N164

<400>  18
guuuccgacc acgacccaac guuacugccc accac                                  35


<210>  19
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre 4F01

<400>  19
agcagcacac gaccagugug ccccacaccc aguggugguc uguggugugc                  50


<210>  20
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre 4F04

<400>  20
ccguccacca gaccaacgua caaacuccgc ugguggucgc cuacccuggc                  50


<210>  21
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre 4F05

<400>  21
gccgcaggcu acaccacagc uuccccuuca gcguguugug gauacucggc                  50


<210>  22
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre R01

<400>  22
ugccgcacua cagcuugguc ugcauauccu cugcgcacag cuccaugugc                  50


<210>  23
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre R02

<400>  23
gcacgauguc caugaccaac uccagucacg gcccugcagc guuaggcugu                  50


<210>  24
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre R03

<400>  24
ccagcaucac cagcggcacg acgucggacg gcuggcuggu ccgucaccgu                  50


<210>  25
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre R04

<400>  25
gcagagcuac acggugcaag uagcacgucc ugccaugcau gcagugcugc                  50


<210>  26
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre R05

<400>  26
cgggaagcag cacgacggcc ucaaugcacu ugccgguugg uuucggcugc                  50


<210>  27
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre R84

<400>  27
cugcgaagug cccaagacca uauccacugc acacgacagc ugaugguggc                  50


<210>  28
<211>  50
<212>  RNA
<213>  Artificial

<220>
<223>  Squence spcifique de laptamre P91

<400>  28
gcuacacaca caucgcacgu cacccacuau ggggacaucu ugcggcgugc                  50


<210>  29
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  Squence amorce P72 des aptamres N, en 5

<400>  29
gggagaguau ccguugaggc uga                                               23


<210>  30
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  Squence amorce P73 des aptamres 4F, F, R et P, en 5

<400>  30
gggagaguau ccguuggagg cau                                               23


<210>  31
<211>  23
<212>  RNA
<213>  Artificial

<220>
<223>  Squence amorce PiRT en 3

<400>  31
agaucggaag agcgucgugu agg                                               23


<210>  32
<211>  24
<212>  RNA
<213>  Artificial

<220>
<223>  Squence G de 24 nts en 3

<400>  32
gcauugcccc agcgugacug ccua                                              24


<210>  33
<211>  47
<212>  RNA
<213>  Artificial

<220>
<223>  Squence PiRT-G : combinaison amorce PiTR + squence G, en 3

<400>  33
agaucggaag agcgucgugu agggcauugc cccagcguga cugccua                     47


<210>  34
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N30

<400>  34
gggagaguau ccguugaggc ugaucgaucc acguccgaca acgcguuuac ucgccaucag       60

aucggaagag cgucguguag g                                                 81


<210>  35
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N124

<400>  35
gggagaguau ccguugaggc ugauccgacc augcuucaac uuauaccucg gggacuguag       60

aucggaagag cgucguguag g                                                 81


<210>  36
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N3

<400>  36
gggagaguau ccguugaggc ugacaacgcg uuuaccucac accacgucau ccguugccag       60

aucggaagag cgucguguag g                                                 81


<210>  37
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre 4F02

<400>  37
gggagaguau ccguuggagg caugcuggca gcacgcaccg cugaccgcug gcugcacuau       60

gcguguggag ugcagaucgg aagagcgucg uguagg                                 96


<210>  38
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre 4F03

<400>  38
gggagaguau ccguuggagg caugcaacag acgcaccgua cacacaucuu ggccguuggc       60

ugcccgacca gccagaucgg aagagcgucg uguagg                                 96


<210>  39
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre F124

<400>  39
gggagaguau ccguuggagg caucacggac accuacccga cggcauguca ggacacaugu       60

ugugcuccgu gugagaucgg aagagcgucg uguagg                                 96


<210>  40
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre P65

<400>  40
gggagaguau ccguuggagg caucgcacag uguacaccua cacacagcau accuguuggc       60

aucccagguu gccagaucgg aagagcgucg uguagg                                 96


<210>  41
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N0

<400>  41
gggagaguau ccguugaggc ugaucagucc aguacgagac gcguuuaccu ccacugcaag       60

aucggaagag cgucguguag g                                                 81


<210>  42
<211>  80
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N1

<400>  42
gggagaguau ccguugaggc ugaauccgac caacccaacg cguuuaccuc accugcaaga       60

ucggaagagc gucguguagg                                                   80


<210>  43
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N2

<400>  43
gggagaguau ccguugaggc ugauuccgac cgccgcaacu uauagguauc ccgcugcaag       60

aucggaagag cgucguguag g                                                 81


<210>  44
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N4

<400>  44
gggagaguau ccguugaggc ugaacgcguu uacuccgcua guacgaaccc gauugcccag       60

aucggaagag cgucguguag g                                                 81


<210>  45
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N5

<400>  45
gggagaguau ccguugaggc ugaagccaug cugucaacuu uuaacucguc accgcucgag       60

aucggaagag cgucguguag g                                                 81


<210>  46
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N15

<400>  46
gggagaguau ccguugaggc ugaaucggcc acagucgaca acuuugaaau ccaccugcag       60

aucggaagag cgucguguag g                                                 81


<210>  47
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N20

<400>  47
gggagaguau ccguugaggc ugagcagcac augaccucac cuuuuacucu gcgcugcaag       60

aucggaagag cgucguguag g                                                 81


<210>  48
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N37

<400>  48
gggagaguau ccguugaggc ugaucagucc agcaccaacg ccguuugcuc ucgacuacag       60

aucggaagag cgucguguag g                                                 81


<210>  49
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N62

<400>  49
gggagaguau ccguugaggc ugaguuuccg aacggcccaa cuuugaaauc cccgcccgag       60

aucggaagag cgucguguag g                                                 81


<210>  50
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N73

<400>  50
gggagaguau ccguugaggc ugacaacuug aaaucccaac ccugcagccg ugucugguag       60

aucggaagag cgucguguag g                                                 81


<210>  51
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre N164

<400>  51
gggagaguau ccguugaggc ugaguuuccg accacgaccc aacguuacug cccaccacag       60

aucggaagag cgucguguag g                                                 81


<210>  52
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre 4F01

<400>  52
gggagaguau ccguuggagg cauagcagca cacgaccagu gugccccaca cccaguggug       60

gucuguggug ugcagaucgg aagagcgucg uguagg                                 96


<210>  53
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre 4F04

<400>  53
gggagaguau ccguuggagg cauccgucca ccagaccaac guacaaacuc cgcugguggu       60

cgccuacccu ggcagaucgg aagagcgucg uguagg                                 96


<210>  54
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre 4F05

<400>  54
gggagaguau ccguuggagg caugccgcag gcuacaccac agcuuccccu ucagcguguu       60

guggauacuc ggcagaucgg aagagcgucg uguagg                                 96


<210>  55
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre R01

<400>  55
gggagaguau ccguuggagg cauugccgca cuacagcuug gucugcauau ccucugcgca       60

cagcuccaug ugcagaucgg aagagcgucg uguagg                                 96


<210>  56
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre R02

<400>  56
gggagaguau ccguuggagg caugcacgau guccaugacc aacuccaguc acggcccugc       60

agcguuaggc uguagaucgg aagagcgucg uguagg                                 96


<210>  57
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre R03

<400>  57
gggagaguau ccguuggagg cauccagcau caccagcggc acgacgucgg acggcuggcu       60

gguccgucac cguagaucgg aagagcgucg uguagg                                 96


<210>  58
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre R04

<400>  58
gggagaguau ccguuggagg caugcagagc uacacggugc aaguagcacg uccugccaug       60

caugcagugc ugcagaucgg aagagcgucg uguagg                                 96


<210>  59
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre R05

<400>  59
gggagaguau ccguuggagg caucgggaag cagcacgacg gccucaaugc acuugccggu       60

ugguuucggc ugcagaucgg aagagcgucg uguagg                                 96


<210>  60
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre R84

<400>  60
gggagaguau ccguuggagg caucugcgaa gugcccaaga ccauauccac ugcacacgac       60

agcugauggu ggcagaucgg aagagcgucg uguagg                                 96


<210>  61
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence complte de laptamre P91

<400>  61
gggagaguau ccguuggagg caugcuacac acacaucgca cgucacccac uauggggaca       60

ucuugcggcg ugcagaucgg aagagcgucg uguagg                                 96


<210>  62
<211>  96
<212>  RNA
<213>  Artificial

<220>
<223>  Squence aptamre alatoire Scr-1

<400>  62
gggagaguau ccguuggagg cauaucguuc agcgugggau cugcuacaac uccugagugc       60

uacauguacg agaagaucgg aagagcgucg uguagg                                 96


<210>  63
<211>  81
<212>  RNA
<213>  Artificial

<220>
<223>  Squence aptamre alatoire Scr-2

<400>  63
gggagaguau ccguugaggc ugauucaaca ccguuugacg uucuugguau cggaagacag       60

aucggaagag cgucguguag g                                                 81


<210>  64
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Squence aptamre ADN alatoire SCRAMBLE

<400>  64
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatct         58


<210>  65
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Squence aptamre ADN art antrieur M5-15

<400>  65
atagtcccat cattcattgt atggtacggc gcggtggcgg gtgcgtggag atattagcaa       60

gtgtca                                                                  66


<210>  66
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Squence aptamre ADN art antrieur T-SO508

<400>  66
atactgccat tcatttcatt tgcctgtggt gttggggcgg gtgcgtttag atatcagcat       60

gtgtca                                                                  66


<210>  67
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Squence aptamre ADN art antrieur F5R1

<400>  67
atcgagtgtg tacggggtcc ggtagggtgg cgaggtcttc ctgtcgtagc aggatcca         58


<210>  68
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Squence aptamre ADN art antrieur F5R2

<400>  68
atcgagtgga cgagtgcctc cggtacgagc tgtctgatgg gtttgcgcgc aggatcca         58


<210>  69
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Squence aptamre ADN art antrieur Tau 3146

<400>  69
gcctgttgtg agcctcctgt cgaacctttg gggtggcttg acgaagaaag tagttgagcg       60

tttattcttg tctccc                                                       76


