                         SEQUENCE LISTING

<110>  Complement Therapeutics Limited
       
<120>  Inhibitory nucleic acids for factor h family proteins

<130>  008267825

<140>  GB2107586.6
<141>  2021-05-27

<160>  227   

<170>  PatentIn version 3.5

<210>  1
<211>  1231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Factor H (FH)

<400>  1

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  2
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human FH-like protein 1 (FHL-1)

<400>  2

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  3
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 1 (FHR1)

<400>  3

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 
    130                 135                 140                 


Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser 
145                 150                 155                 160 


Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 
                165                 170                 175     


Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 
            180                 185                 190         


Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 
        195                 200                 205             


Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 
    210                 215                 220                 


Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu 
225                 230                 235                 240 


Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 
                245                 250                 255     


Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 
            260                 265                 270         


Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 
        275                 280                 285             


Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 
    290                 295                 300                 


Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly 
305                 310                 315                 320 


Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
                325                 330 


<210>  4
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 2 (FHR2), isoform 1

<400>  4

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile 
    130                 135                 140                 


Ser Ala Glu Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Ser Val Tyr Ala Pro Gly Ser Ser Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Asn Gln Ile Thr Cys 
            180                 185                 190         


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu Asp Pro Cys Val 
        195                 200                 205             


Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile Lys Leu Lys Trp Thr 
    210                 215                 220                 


Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp Ile Val Glu Phe Val 
225                 230                 235                 240 


Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His Ser Phe Arg Ala Met 
                245                 250                 255     


Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys Glu Glu Lys 
            260                 265                 270 


<210>  5
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 2 (FHR2), isoform 2

<400>  5

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly Glu Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 
            20                  25                  30          


Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Ala Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ser 
    130                 135                 140                 


Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn 
145                 150                 155                 160 


Asn Gln Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys 
                165                 170                 175     


Leu Asp Pro Cys Val Ile Ser Gln Glu Ile Met Glu Lys Tyr Asn Ile 
            180                 185                 190         


Lys Leu Lys Trp Thr Asn Gln Gln Lys Leu Tyr Ser Arg Thr Gly Asp 
        195                 200                 205             


Ile Val Glu Phe Val Cys Lys Ser Gly Tyr His Pro Thr Lys Ser His 
    210                 215                 220                 


Ser Phe Arg Ala Met Cys Gln Asn Gly Lys Leu Val Tyr Pro Ser Cys 
225                 230                 235                 240 


Glu Glu Lys 
            


<210>  6
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 3 (FHR3), isoform 1

<400>  6

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg 
    130                 135                 140                 


Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu 
145                 150                 155                 160 


Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys 
                165                 170                 175     


Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys 
            180                 185                 190         


Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile Cys Ile Asn Ser Ser Glu 
        195                 200                 205             


Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser Phe 
    210                 215                 220                 


Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys Gln 
225                 230                 235                 240 


Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn Gly 
                245                 250                 255     


Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr Glu 
            260                 265                 270         


Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg Ser Asp Arg 
        275                 280                 285             


Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys Leu 
    290                 295                 300                 


Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala Val Cys Arg 
305                 310                 315                 320 


Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330 


<210>  7
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 3 (FHR3), isoform 2

<400>  7

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly 
            20                  25                  30          


Leu Phe His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly 
        35                  40                  45              


Lys Tyr Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly 
    50                  55                  60                  


Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asn Gly Trp Ser Pro Ala 
65                  70                  75                  80  


Val Pro Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr 
                85                  90                  95      


Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser Thr Glu Val 
            100                 105                 110         


Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val Thr 
        115                 120                 125             


Cys Thr Glu Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Asn 
    130                 135                 140                 


Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr 
145                 150                 155                 160 


Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr 
                165                 170                 175     


Gln Cys Gln Pro Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys 
            180                 185                 190         


Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile 
        195                 200                 205             


Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile Lys Leu Lys Gly Arg 
    210                 215                 220                 


Ser Asp Arg Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met 
225                 230                 235                 240 


Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe Gln Ala 
                245                 250                 255     


Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
            260                 265                 


<210>  8
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 4 (FHR4A)

<400>  8

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Val Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Glu Glu 
            100                 105                 110         


Thr Gln Tyr Asn Cys Lys Pro Gly Tyr Ala Thr Ala Glu Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Thr Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Trp Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ser Ser Tyr Gly Asn Thr Thr Asp Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Leu Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Asn Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Pro Gln Lys Val Tyr Leu Pro Trp Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Lys Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Asp Trp Ser Glu Pro Pro Arg Cys Ile Ser Met Lys Pro Cys Glu 
            260                 265                 270         


Phe Pro Glu Ile Gln His Gly His Leu Tyr Tyr Glu Asn Thr Arg Arg 
        275                 280                 285             


Pro Tyr Phe Pro Val Ala Thr Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp 
    290                 295                 300                 


Gln Asn Phe Val Thr Pro Ser Gly Ser Tyr Trp Asp Tyr Ile His Cys 
305                 310                 315                 320 


Thr Gln Asp Gly Trp Leu Pro Thr Val Pro Cys Leu Arg Thr Cys Ser 
                325                 330                 335     


Lys Ser Asp Ile Glu Ile Glu Asn Gly Phe Ile Ser Glu Ser Ser Ser 
            340                 345                 350         


Ile Tyr Ile Leu Asn Lys Glu Ile Gln Tyr Lys Cys Lys Pro Gly Tyr 
        355                 360                 365             


Ala Thr Ala Asp Gly Asn Ser Ser Gly Ser Ile Thr Cys Leu Gln Asn 
    370                 375                 380                 


Gly Trp Ser Ala Gln Pro Ile Cys Ile Lys Phe Cys Asp Met Pro Val 
385                 390                 395                 400 


Phe Glu Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His 
                405                 410                 415     


Asp Thr Leu Asp Tyr Glu Cys Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly 
            420                 425                 430         


Asn Thr Thr Gly Ser Ile Val Cys Gly Glu Asp Gly Trp Ser His Phe 
        435                 440                 445             


Pro Thr Cys Tyr Asn Ser Ser Glu Lys Cys Gly Pro Pro Pro Pro Ile 
    450                 455                 460                 


Ser Asn Gly Asp Thr Thr Ser Phe Leu Leu Lys Val Tyr Val Pro Gln 
465                 470                 475                 480 


Ser Arg Val Glu Tyr Gln Cys Gln Ser Tyr Tyr Glu Leu Gln Gly Ser 
                485                 490                 495     


Asn Tyr Val Thr Cys Ser Asn Gly Glu Trp Ser Glu Pro Pro Arg Cys 
            500                 505                 510         


Ile His Pro Cys Ile Ile Thr Glu Glu Asn Met Asn Lys Asn Asn Ile 
        515                 520                 525             


Gln Leu Lys Gly Lys Ser Asp Ile Lys Tyr Tyr Ala Lys Thr Gly Asp 
    530                 535                 540                 


Thr Ile Glu Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val 
545                 550                 555                 560 


Leu Ser Phe Gln Ala Val Cys Arg Glu Gly Ile Val Glu Tyr Pro Arg 
                565                 570                 575     


Cys Glu 
        


<210>  9
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 4 (FHR4B)

<400>  9

Met Leu Leu Leu Ile Asn Val Ile Leu Thr Leu Trp Val Ser Cys Ala 
1               5                   10                  15      


Asn Gly Gln Glu Val Lys Pro Cys Asp Phe Pro Glu Ile Gln His Gly 
            20                  25                  30          


Gly Leu Tyr Tyr Lys Ser Leu Arg Arg Leu Tyr Phe Pro Ala Ala Ala 
        35                  40                  45              


Gly Gln Ser Tyr Ser Tyr Tyr Cys Asp Gln Asn Phe Val Thr Pro Ser 
    50                  55                  60                  


Gly Ser Tyr Trp Asp Tyr Ile His Cys Thr Gln Asp Gly Trp Ser Pro 
65                  70                  75                  80  


Thr Val Pro Cys Leu Arg Thr Cys Ser Lys Ser Asp Ile Glu Ile Glu 
                85                  90                  95      


Asn Gly Phe Ile Ser Glu Ser Ser Ser Ile Tyr Ile Leu Asn Lys Glu 
            100                 105                 110         


Ile Gln Tyr Lys Cys Lys Pro Gly Tyr Ala Thr Ala Asp Gly Asn Ser 
        115                 120                 125             


Ser Gly Ser Ile Thr Cys Leu Gln Asn Gly Trp Ser Ala Gln Pro Ile 
    130                 135                 140                 


Cys Ile Lys Phe Cys Asp Met Pro Val Phe Glu Asn Ser Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr Leu Asp Tyr Glu Cys 
                165                 170                 175     


Tyr Asp Gly Tyr Glu Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val 
            180                 185                 190         


Cys Gly Glu Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser 
        195                 200                 205             


Glu Lys Cys Gly Pro Pro Pro Pro Ile Ser Asn Gly Asp Thr Thr Ser 
    210                 215                 220                 


Phe Leu Leu Lys Val Tyr Val Pro Gln Ser Arg Val Glu Tyr Gln Cys 
225                 230                 235                 240 


Gln Ser Tyr Tyr Glu Leu Gln Gly Ser Asn Tyr Val Thr Cys Ser Asn 
                245                 250                 255     


Gly Glu Trp Ser Glu Pro Pro Arg Cys Ile His Pro Cys Ile Ile Thr 
            260                 265                 270         


Glu Glu Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Gly Lys Ser Asp 
        275                 280                 285             


Ile Lys Tyr Tyr Ala Lys Thr Gly Asp Thr Ile Glu Phe Met Cys Lys 
    290                 295                 300                 


Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe Gln Ala Val Cys 
305                 310                 315                 320 


Arg Glu Gly Ile Val Glu Tyr Pro Arg Cys Glu 
                325                 330     


<210>  10
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor H-related 5 (FHR5)

<400>  10

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly Glu Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe 
            20                  25                  30          


Leu Tyr Asp Glu Glu Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly 
        35                  40                  45              


Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 
    50                  55                  60                  


Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr 
65                  70                  75                  80  


Pro Lys Cys Leu Arg Met Cys Ser Phe Pro Phe Val Lys Asn Gly His 
                85                  90                  95      


Ser Glu Ser Ser Gly Leu Ile His Leu Glu Gly Asp Thr Val Gln Ile 
            100                 105                 110         


Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn Asn Glu Lys Asn Ile Ser 
        115                 120                 125             


Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys 
    130                 135                 140                 


Gly Glu Cys His Val Pro Ile Leu Glu Ala Asn Val Asp Ala Gln Pro 
145                 150                 155                 160 


Lys Lys Glu Ser Tyr Lys Val Gly Asp Val Leu Lys Phe Ser Cys Arg 
                165                 170                 175     


Lys Asn Leu Ile Arg Val Gly Ser Asp Ser Val Gln Cys Tyr Gln Phe 
            180                 185                 190         


Gly Trp Ser Pro Asn Phe Pro Thr Cys Lys Gly Gln Val Arg Ser Cys 
        195                 200                 205             


Gly Pro Pro Pro Gln Leu Ser Asn Gly Glu Val Lys Glu Ile Arg Lys 
    210                 215                 220                 


Glu Glu Tyr Gly His Asn Glu Val Val Glu Tyr Asp Cys Asn Pro Asn 
225                 230                 235                 240 


Phe Ile Ile Asn Gly Pro Lys Lys Ile Gln Cys Val Asp Gly Glu Trp 
                245                 250                 255     


Thr Thr Leu Pro Thr Cys Val Glu Gln Val Lys Thr Cys Gly Tyr Ile 
            260                 265                 270         


Pro Glu Leu Glu Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln 
        275                 280                 285             


His Gly Val Ser Val Glu Val Asn Cys Arg Asn Glu Tyr Ala Met Ile 
    290                 295                 300                 


Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp Thr Glu Leu Pro 
305                 310                 315                 320 


Met Cys Val Ala Thr His Gln Leu Lys Arg Cys Lys Ile Ala Gly Val 
                325                 330                 335     


Asn Ile Lys Thr Leu Leu Lys Leu Ser Gly Lys Glu Phe Asn His Asn 
            340                 345                 350         


Ser Arg Ile Arg Tyr Arg Cys Ser Asp Ile Phe Arg Tyr Arg His Ser 
        355                 360                 365             


Val Cys Ile Asn Gly Lys Trp Asn Pro Glu Val Asp Cys Thr Glu Lys 
    370                 375                 380                 


Arg Glu Gln Phe Cys Pro Pro Pro Pro Gln Ile Pro Asn Ala Gln Asn 
385                 390                 395                 400 


Met Thr Thr Thr Val Asn Tyr Gln Asp Gly Glu Lys Val Ala Val Leu 
                405                 410                 415     


Cys Lys Glu Asn Tyr Leu Leu Pro Glu Ala Lys Glu Ile Val Cys Lys 
            420                 425                 430         


Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu Ser Thr Ala Tyr 
        435                 440                 445             


Cys Gly Pro Pro Pro Ser Ile Asn Asn Gly Asp Thr Thr Ser Phe Pro 
    450                 455                 460                 


Leu Ser Val Tyr Pro Pro Gly Ser Thr Val Thr Tyr Arg Cys Gln Ser 
465                 470                 475                 480 


Phe Tyr Lys Leu Gln Gly Ser Val Thr Val Thr Cys Arg Asn Lys Gln 
                485                 490                 495     


Trp Ser Glu Pro Pro Arg Cys Leu Asp Pro Cys Val Val Ser Glu Glu 
            500                 505                 510         


Asn Met Asn Lys Asn Asn Ile Gln Leu Lys Trp Arg Asn Asp Gly Lys 
        515                 520                 525             


Leu Tyr Ala Lys Thr Gly Asp Ala Val Glu Phe Gln Cys Lys Phe Pro 
    530                 535                 540                 


His Lys Ala Met Ile Ser Ser Pro Pro Phe Arg Ala Ile Cys Gln Glu 
545                 550                 555                 560 


Gly Lys Phe Glu Tyr Pro Ile Cys Glu 
                565                 


<210>  11
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement Factor I (FI)

<400>  11

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  12
<211>  1663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complement factor C3

<400>  12

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  13
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human C3 beta chain

<400>  13

Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg Leu Glu Ser 
1               5                   10                  15      


Glu Glu Thr Met Val Leu Glu Ala His Asp Ala Gln Gly Asp Val Pro 
            20                  25                  30          


Val Thr Val Thr Val His Asp Phe Pro Gly Lys Lys Leu Val Leu Ser 
        35                  40                  45              


Ser Glu Lys Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val 
    50                  55                  60                  


Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe Lys Ser Glu Lys Gly Arg 
65                  70                  75                  80  


Asn Lys Phe Val Thr Val Gln Ala Thr Phe Gly Thr Gln Val Val Glu 
                85                  90                  95      


Lys Val Val Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Thr 
            100                 105                 110         


Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg Ile Phe 
        115                 120                 125             


Thr Val Asn His Lys Leu Leu Pro Val Gly Arg Thr Val Met Val Asn 
    130                 135                 140                 


Ile Glu Asn Pro Glu Gly Ile Pro Val Lys Gln Asp Ser Leu Ser Ser 
145                 150                 155                 160 


Gln Asn Gln Leu Gly Val Leu Pro Leu Ser Trp Asp Ile Pro Glu Leu 
                165                 170                 175     


Val Asn Met Gly Gln Trp Lys Ile Arg Ala Tyr Tyr Glu Asn Ser Pro 
            180                 185                 190         


Gln Gln Val Phe Ser Thr Glu Phe Glu Val Lys Glu Tyr Val Leu Pro 
        195                 200                 205             


Ser Phe Glu Val Ile Val Glu Pro Thr Glu Lys Phe Tyr Tyr Ile Tyr 
    210                 215                 220                 


Asn Glu Lys Gly Leu Glu Val Thr Ile Thr Ala Arg Phe Leu Tyr Gly 
225                 230                 235                 240 


Lys Lys Val Glu Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp Gly 
                245                 250                 255     


Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu Lys Arg Ile Pro Ile Glu 
            260                 265                 270         


Asp Gly Ser Gly Glu Val Val Leu Ser Arg Lys Val Leu Leu Asp Gly 
        275                 280                 285             


Val Gln Asn Pro Arg Ala Glu Asp Leu Val Gly Lys Ser Leu Tyr Val 
    290                 295                 300                 


Ser Ala Thr Val Ile Leu His Ser Gly Ser Asp Met Val Gln Ala Glu 
305                 310                 315                 320 


Arg Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe Thr 
                325                 330                 335     


Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met Pro Phe Asp Leu Met Val 
            340                 345                 350         


Phe Val Thr Asn Pro Asp Gly Ser Pro Ala Tyr Arg Val Pro Val Ala 
        355                 360                 365             


Val Gln Gly Glu Asp Thr Val Gln Ser Leu Thr Gln Gly Asp Gly Val 
    370                 375                 380                 


Ala Lys Leu Ser Ile Asn Thr His Pro Ser Gln Lys Pro Leu Ser Ile 
385                 390                 395                 400 


Thr Val Arg Thr Lys Lys Gln Glu Leu Ser Glu Ala Glu Gln Ala Thr 
                405                 410                 415     


Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr Val Gly Asn Ser Asn Asn 
            420                 425                 430         


Tyr Leu His Leu Ser Val Leu Arg Thr Glu Leu Arg Pro Gly Glu Thr 
        435                 440                 445             


Leu Asn Val Asn Phe Leu Leu Arg Met Asp Arg Ala His Glu Ala Lys 
    450                 455                 460                 


Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn Lys Gly Arg Leu Leu Lys 
465                 470                 475                 480 


Ala Gly Arg Gln Val Arg Glu Pro Gly Gln Asp Leu Val Val Leu Pro 
                485                 490                 495     


Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser Phe Arg Leu Val Ala Tyr 
            500                 505                 510         


Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg Glu Val Val Ala Asp Ser 
        515                 520                 525             


Val Trp Val Asp Val Lys Asp Ser Cys Val Gly Ser Leu Val Val Lys 
    530                 535                 540                 


Ser Gly Gln Ser Glu Asp Arg Gln Pro Val Pro Gly Gln Gln Met Thr 
545                 550                 555                 560 


Leu Lys Ile Glu Gly Asp His Gly Ala Arg Val Val Leu Val Ala Val 
                565                 570                 575     


Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn Lys Leu Thr Gln Ser 
            580                 585                 590         


Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile Gly Cys Thr Pro Gly 
        595                 600                 605             


Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser Asp Ala Gly Leu Thr Phe 
    610                 615                 620                 


Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln Arg Ala Glu Leu Gln Cys 
625                 630                 635                 640 


Pro Gln Pro Ala Ala 
                645 


<210>  14
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human C3 alpha' chain

<400>  14

Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 
1               5                   10                  15      


Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu 
            20                  25                  30          


Pro Pro Lys Asn Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys 
        35                  40                  45              


Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys 
    50                  55                  60                  


Lys Gly Ile Cys Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp 
65                  70                  75                  80  


Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln 
                85                  90                  95      


Val Glu Ile Arg Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu 
            100                 105                 110         


Lys Val Arg Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala 
        115                 120                 125             


Thr Thr Lys Arg Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser 
    130                 135                 140                 


Ser Leu Ser Val Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln 
145                 150                 155                 160 


Glu Val Glu Val Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly 
                165                 170                 175     


Val Arg Lys Ser Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys 
            180                 185                 190         


Thr Val Ala Val Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly 
        195                 200                 205             


Val Gln Lys Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro 
    210                 215                 220                 


Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala 
225                 230                 235                 240 


Gln Met Thr Glu Asp Ala Val Asp Ala Glu Arg Leu Lys His Leu Ile 
                245                 250                 255     


Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro 
            260                 265                 270         


Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln Trp Glu Lys 
        275                 280                 285             


Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile Lys Lys Gly 
    290                 295                 300                 


Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala Phe Ala Ala 
305                 310                 315                 320 


Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys 
                325                 330                 335     


Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln Val Leu 
            340                 345                 350         


Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro Asp Gly 
        355                 360                 365             


Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met Ile Gly Gly 
    370                 375                 380                 


Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala Phe Val Leu 
385                 390                 395                 400 


Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser 
                405                 410                 415     


Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr 
            420                 425                 430         


Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu 
        435                 440                 445             


Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Thr 
    450                 455                 460                 


Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys Gln Leu Tyr 
465                 470                 475                 480 


Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu Gln Leu Lys 
                485                 490                 495     


Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg 
            500                 505                 510         


Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
        515                 520                 525             


Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His Gln Glu Leu 
    530                 535                 540                 


Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg Ser Ser Lys Ile Thr 
545                 550                 555                 560 


His Arg Ile His Trp Glu Ser Ala Ser Leu Leu Arg Ser Glu Glu Thr 
                565                 570                 575     


Lys Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly Lys Gly Gln Gly 
            580                 585                 590         


Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala Lys Asp Gln Leu 
        595                 600                 605             


Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys Pro Ala Pro Glu 
    610                 615                 620                 


Thr Glu Lys Arg Pro Gln Asp Ala Lys Asn Thr Met Ile Leu Glu Ile 
625                 630                 635                 640 


Cys Thr Arg Tyr Arg Gly Asp Gln Asp Ala Thr Met Ser Ile Leu Asp 
                645                 650                 655     


Ile Ser Met Met Thr Gly Phe Ala Pro Asp Thr Asp Asp Leu Lys Gln 
            660                 665                 670         


Leu Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr Glu Leu Asp Lys 
        675                 680                 685             


Ala Phe Ser Asp Arg Asn Thr Leu Ile Ile Tyr Leu Asp Lys Val Ser 
    690                 695                 700                 


His Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His Gln Tyr Phe Asn 
705                 710                 715                 720 


Val Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn 
                725                 730                 735     


Leu Glu Glu Ser Cys Thr Arg Phe Tyr His Pro Glu Lys Glu Asp Gly 
            740                 745                 750         


Lys Leu Asn Lys Leu Cys Arg Asp Glu Leu Cys Arg Cys Ala Glu Glu 
        755                 760                 765             


Asn Cys Phe Ile Gln Lys Ser Asp Asp Lys Val Thr Leu Glu Glu Arg 
    770                 775                 780                 


Leu Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Thr Arg 
785                 790                 795                 800 


Leu Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala 
                805                 810                 815     


Ile Glu Gln Thr Ile Lys Ser Gly Ser Asp Glu Val Gln Val Gly Gln 
            820                 825                 830         


Gln Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala Leu Lys Leu 
        835                 840                 845             


Glu Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp 
    850                 855                 860                 


Gly Glu Lys Pro Asn Leu Ser Tyr Ile Ile Gly Lys Asp Thr Trp Val 
865                 870                 875                 880 


Glu His Trp Pro Glu Glu Asp Glu Cys Gln Asp Glu Glu Asn Gln Lys 
                885                 890                 895     


Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu Ser Met Val Val Phe Gly 
            900                 905                 910         


Cys Pro Asn 
        915 


<210>  15
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human C3a

<400>  15

Ser Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro 
1               5                   10                  15      


Lys Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met 
            20                  25                  30          


Arg Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala 
        35                  40                  45              


Cys Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg 
    50                  55                  60                  


Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg 
65                  70                  75          


<210>  16
<211>  915
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human C3b alpha' chain fragment 1

<400>  16

Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 
1               5                   10                  15      


Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu 
            20                  25                  30          


Pro Pro Lys Asn Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys 
        35                  40                  45              


Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys 
    50                  55                  60                  


Lys Gly Ile Cys Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp 
65                  70                  75                  80  


Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln 
                85                  90                  95      


Val Glu Ile Arg Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu 
            100                 105                 110         


Lys Val Arg Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala 
        115                 120                 125             


Thr Thr Lys Arg Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser 
    130                 135                 140                 


Ser Leu Ser Val Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln 
145                 150                 155                 160 


Glu Val Glu Val Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly 
                165                 170                 175     


Val Arg Lys Ser Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys 
            180                 185                 190         


Thr Val Ala Val Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly 
        195                 200                 205             


Val Gln Lys Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro 
    210                 215                 220                 


Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala 
225                 230                 235                 240 


Gln Met Thr Glu Asp Ala Val Asp Ala Glu Arg Leu Lys His Leu Ile 
                245                 250                 255     


Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro 
            260                 265                 270         


Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln Trp Glu Lys 
        275                 280                 285             


Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile Lys Lys Gly 
    290                 295                 300                 


Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala Phe Ala Ala 
305                 310                 315                 320 


Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val Val Lys 
                325                 330                 335     


Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln Val Leu 
            340                 345                 350         


Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro Asp Gly 
        355                 360                 365             


Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met Ile Gly Gly 
    370                 375                 380                 


Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala Phe Val Leu 
385                 390                 395                 400 


Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val Asn Ser 
                405                 410                 415     


Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala Asn Tyr 
            420                 425                 430         


Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr Ala Leu 
        435                 440                 445             


Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe Leu Thr 
    450                 455                 460                 


Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys Gln Leu Tyr 
465                 470                 475                 480 


Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu Gln Leu Lys 
                485                 490                 495     


Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn Glu Gln Arg 
            500                 505                 510         


Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met Val Phe 
        515                 520                 525             


Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His Gln Glu Leu 
    530                 535                 540                 


Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg Ser Ser Lys Ile Thr 
545                 550                 555                 560 


His Arg Ile His Trp Glu Ser Ala Ser Leu Leu Arg Ser Glu Glu Thr 
                565                 570                 575     


Lys Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly Lys Gly Gln Gly 
            580                 585                 590         


Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala Lys Asp Gln Leu 
        595                 600                 605             


Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys Pro Ala Pro Glu 
    610                 615                 620                 


Thr Glu Lys Arg Pro Gln Asp Ala Lys Asn Thr Met Ile Leu Glu Ile 
625                 630                 635                 640 


Cys Thr Arg Tyr Arg Gly Asp Gln Asp Ala Thr Met Ser Ile Leu Asp 
                645                 650                 655     


Ile Ser Met Met Thr Gly Phe Ala Pro Asp Thr Asp Asp Leu Lys Gln 
            660                 665                 670         


Leu Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr Glu Leu Asp Lys 
        675                 680                 685             


Ala Phe Ser Asp Arg Asn Thr Leu Ile Ile Tyr Leu Asp Lys Val Ser 
    690                 695                 700                 


His Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His Gln Tyr Phe Asn 
705                 710                 715                 720 


Val Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr Ala Tyr Tyr Asn 
                725                 730                 735     


Leu Glu Glu Ser Cys Thr Arg Phe Tyr His Pro Glu Lys Glu Asp Gly 
            740                 745                 750         


Lys Leu Asn Lys Leu Cys Arg Asp Glu Leu Cys Arg Cys Ala Glu Glu 
        755                 760                 765             


Asn Cys Phe Ile Gln Lys Ser Asp Asp Lys Val Thr Leu Glu Glu Arg 
    770                 775                 780                 


Leu Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Thr Arg 
785                 790                 795                 800 


Leu Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu Tyr Ile Met Ala 
                805                 810                 815     


Ile Glu Gln Thr Ile Lys Ser Gly Ser Asp Glu Val Gln Val Gly Gln 
            820                 825                 830         


Gln Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu Ala Leu Lys Leu 
        835                 840                 845             


Glu Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser Ser Asp Phe Trp 
    850                 855                 860                 


Gly Glu Lys Pro Asn Leu Ser Tyr Ile Ile Gly Lys Asp Thr Trp Val 
865                 870                 875                 880 


Glu His Trp Pro Glu Glu Asp Glu Cys Gln Asp Glu Glu Asn Gln Lys 
                885                 890                 895     


Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu Ser Met Val Val Phe Gly 
            900                 905                 910         


Cys Pro Asn 
        915 


<210>  17
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human C3 alpha' chain fragment 2

<400>  17

Ser Glu Glu Thr Lys Glu Asn Glu Gly Phe Thr Val Thr Ala Glu Gly 
1               5                   10                  15      


Lys Gly Gln Gly Thr Leu Ser Val Val Thr Met Tyr His Ala Lys Ala 
            20                  25                  30          


Lys Asp Gln Leu Thr Cys Asn Lys Phe Asp Leu Lys Val Thr Ile Lys 
        35                  40                  45              


Pro Ala Pro Glu Thr Glu Lys Arg Pro Gln Asp Ala Lys Asn Thr Met 
    50                  55                  60                  


Ile Leu Glu Ile Cys Thr Arg Tyr Arg Gly Asp Gln Asp Ala Thr Met 
65                  70                  75                  80  


Ser Ile Leu Asp Ile Ser Met Met Thr Gly Phe Ala Pro Asp Thr Asp 
                85                  90                  95      


Asp Leu Lys Gln Leu Ala Asn Gly Val Asp Arg Tyr Ile Ser Lys Tyr 
            100                 105                 110         


Glu Leu Asp Lys Ala Phe Ser Asp Arg Asn Thr Leu Ile Ile Tyr Leu 
        115                 120                 125             


Asp Lys Val Ser His Ser Glu Asp Asp Cys Leu Ala Phe Lys Val His 
    130                 135                 140                 


Gln Tyr Phe Asn Val Glu Leu Ile Gln Pro Gly Ala Val Lys Val Tyr 
145                 150                 155                 160 


Ala Tyr Tyr Asn Leu Glu Glu Ser Cys Thr Arg Phe Tyr His Pro Glu 
                165                 170                 175     


Lys Glu Asp Gly Lys Leu Asn Lys Leu Cys Arg Asp Glu Leu Cys Arg 
            180                 185                 190         


Cys Ala Glu Glu Asn Cys Phe Ile Gln Lys Ser Asp Asp Lys Val Thr 
        195                 200                 205             


Leu Glu Glu Arg Leu Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val 
    210                 215                 220                 


Tyr Lys Thr Arg Leu Val Lys Val Gln Leu Ser Asn Asp Phe Asp Glu 
225                 230                 235                 240 


Tyr Ile Met Ala Ile Glu Gln Thr Ile Lys Ser Gly Ser Asp Glu Val 
                245                 250                 255     


Gln Val Gly Gln Gln Arg Thr Phe Ile Ser Pro Ile Lys Cys Arg Glu 
            260                 265                 270         


Ala Leu Lys Leu Glu Glu Lys Lys His Tyr Leu Met Trp Gly Leu Ser 
        275                 280                 285             


Ser Asp Phe Trp Gly Glu Lys Pro Asn Leu Ser Tyr Ile Ile Gly Lys 
    290                 295                 300                 


Asp Thr Trp Val Glu His Trp Pro Glu Glu Asp Glu Cys Gln Asp Glu 
305                 310                 315                 320 


Glu Asn Gln Lys Gln Cys Gln Asp Leu Gly Ala Phe Thr Glu Ser Met 
                325                 330                 335     


Val Val Phe Gly Cys Pro Asn 
            340             


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3f

<400>  18

Ser Ser Lys Ile Thr His Arg Ile His Trp Glu Ser Ala Ser Leu Leu 
1               5                   10                  15      


Arg 
    


<210>  19
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human C3c alpha' chain fragment 1

<400>  19

Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg 
1               5                   10                  15      


Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu 
            20                  25                  30          


Pro Pro Lys Asn Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys 
        35                  40                  45              


Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys 
    50                  55                  60                  


Lys Gly Ile Cys Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp 
65                  70                  75                  80  


Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln 
                85                  90                  95      


Val Glu Ile Arg Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu 
            100                 105                 110         


Lys Val Arg Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala 
        115                 120                 125             


Thr Thr Lys Arg Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser 
    130                 135                 140                 


Ser Leu Ser Val Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln 
145                 150                 155                 160 


Glu Val Glu Val Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly 
                165                 170                 175     


Val Arg Lys Ser Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys 
            180                 185                 190         


Thr Val Ala Val Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg 
        195                 200                 205     


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH MS peptide

<400>  20

Val Thr Tyr Lys Cys Phe Glu 
1               5           


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHL-1 MS peptide

<400>  21

Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr Leu 
1               5                   10                  15      


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR1 MS peptide

<400>  22

Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr Asp 
1               5                   10                  15      


Glu Glu 
        


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR2 MS peptide 1

<400>  23

Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Ile Ser Ala Glu 
1               5                   10                  15      


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR2 MS peptide 2

<400>  24

Ala Met Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile Leu Tyr Asp 
1               5                   10                  15      


Glu Glu 
        


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR3 MS peptide

<400>  25

Val Ala Cys His Pro Gly Tyr Gly Leu Pro Lys Ala Gln Thr Thr Val 
1               5                   10                  15      


Thr Cys Thr Glu 
            20  


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR4 MS peptide

<400>  26

Tyr Gln Cys Gln Ser Tyr Tyr Glu 
1               5               


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 MS peptide

<400>  27

Arg Gly Trp Ser Thr Pro Pro Ile Cys Ser Phe Thr Lys Gly Glu 
1               5                   10                  15  


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1 peptide

<400>  28

Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp Gly Glu 
1               5                   10              


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.2 peptide

<400>  29

Leu Arg Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser 
1               5                   10                  15      


Asn Leu Asp Glu 
            20  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.3 peptide

<400>  30

Leu Arg Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg 
1               5                   10                  15  


<210>  31
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.4 peptide

<400>  31

Leu Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg Ser Ser Lys Ile 
1               5                   10                  15      


Thr His Arg Ile His Trp Glu 
            20              


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.5 peptide

<400>  32

Leu Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg 
1               5                   10          


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.6 peptide

<400>  33

Arg Leu Gly Arg Glu 
1               5   


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.7 peptide

<400>  34

Ser Ser Lys Ile Thr His Arg Ile His Trp Glu 
1               5                   10      


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.8 peptide

<400>  35

Ser Ala Ser Leu Leu Arg 
1               5       


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.9 peptide

<400>  36

Arg Leu Gly Arg 
1               


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.10 peptide

<400>  37

His Leu Ile Val Thr Pro Ser Gly Cys Gly Glu 
1               5                   10      


<210>  38
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 1

<400>  38

Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser 
1               5                   10                  15      


Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp 
            20                  25                  30          


Gly Val Val Ser Trp Gly Glu 
        35                  


<210>  39
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 2

<400>  39

Gly Thr Cys Val Cys Lys Leu Pro Tyr Gln Cys Pro Lys Asn Gly Thr 
1               5                   10                  15      


Ala Val Cys Ala Thr Asn Arg Arg Ser Phe Pro Thr Tyr Cys Gln Gln 
            20                  25                  30          


Lys Ser Leu Glu 
        35      


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 3

<400>  40

Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser 
1               5                   10                  15      


Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
            20                  25                  


<210>  41
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 4

<400>  41

Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln Gln Gly Ala Asp Thr 
1               5                   10                  15      


Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile Asn Ser Thr Glu 
            20                  25                  30      


<210>  42
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 5

<400>  42

Leu Pro Arg Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe 
1               5                   10                  15      


Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu 
            20                  25                  30  


<210>  43
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 6

<400>  43

Lys Lys Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val 
1               5                   10                  15      


Phe Cys Gln Pro Trp Gln Arg Cys Ile Glu 
            20                  25      


<210>  44
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 7

<400>  44

Leu Cys Cys Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly 
1               5                   10                  15      


Val Cys Ile Pro Ser Gln Tyr Gln Cys Asn Gly Glu 
            20                  25              


<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 8

<400>  45

Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
1               5                   10                  15      


Trp Ser Met Arg Glu 
            20      


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 9

<400>  46

Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr 
1               5                   10                  15      


Glu 
    


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 10

<400>  47

Cys Leu His Pro Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala 
1               5                   10                  15      


Glu 
    


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 11

<400>  48

Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 12

<400>  49

Gly Lys Phe Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu 
1               5                   10                  15  


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 13

<400>  50

Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu 
1               5                   10              


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 14

<400>  51

Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu 
1               5                   10      


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 15

<400>  52

Tyr Val Asp Arg Ile Ile Phe His Glu 
1               5                   


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 16

<400>  53

Cys Leu His Val His Cys Arg Gly Leu Glu 
1               5                   10  


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 17

<400>  54

Arg Val Phe Ser Leu Gln Trp Gly Glu 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 18

<400>  55

Ile Leu Thr Ala Asp Met Asp Ala Glu 
1               5                   


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 19

<400>  56

Lys Val Thr Tyr Thr Ser Gln Glu 
1               5               


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 20

<400>  57

Val Asp Cys Ile Thr Gly Glu 
1               5           


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 21

<400>  58

Asn Cys Gly Lys Pro Glu 
1               5       


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 22

<400>  59

Thr Ser Leu Ala Glu 
1               5   


<210>  60
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 23

<400>  60

Lys Asp Asn Glu 
1               


<210>  61
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.1

<400>  61

Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn Lys Gly Arg Leu 
1               5                   10                  15      


Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln Asp Leu Val Val 
            20                  25                  30          


Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser Phe Arg Leu Val 
        35                  40                  45              


Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg Glu 
    50                  55                  60      


<210>  62
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.2

<400>  62

Arg Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe Thr 
1               5                   10                  15      


Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met Pro Phe Asp Leu Met Val 
            20                  25                  30          


Phe Val Thr Asn Pro Asp Gly Ser Pro Ala Tyr Arg Val Pro Val Ala 
        35                  40                  45              


Val Gln Gly Glu 
    50          


<210>  63
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.3

<400>  63

Lys Val Val Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Thr 
1               5                   10                  15      


Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg Ile Phe 
            20                  25                  30          


Thr Val Asn His Lys Leu Leu Pro Val Gly Arg Thr Val Met Val Asn 
        35                  40                  45              


Ile Glu 
    50  


<210>  64
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.4

<400>  64

Asp Thr Val Gln Ser Leu Thr Gln Gly Asp Gly Val Ala Lys Leu Ser 
1               5                   10                  15      


Ile Asn Thr His Pro Ser Gln Lys Pro Leu Ser Ile Thr Val Arg Thr 
            20                  25                  30          


Lys Lys Gln Glu 
        35      


<210>  65
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.5

<400>  65

Gly Asp His Gly Ala Arg Val Val Leu Val Ala Val Asp Lys Gly Val 
1               5                   10                  15      


Phe Val Leu Asn Lys Lys Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp 
            20                  25                  30          


Val Val Glu 
        35  


<210>  66
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.6

<400>  66

Lys Ala Asp Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly 
1               5                   10                  15      


Val Phe Ser Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln 
            20                  25                  30          


Thr Ala Gln Arg Ala Glu 
        35              


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.7

<400>  67

Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr Val Gly Asn 
1               5                   10                  15      


Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
            20                  25                  


<210>  68
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.8

<400>  68

Ala His Asp Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp 
1               5                   10                  15      


Phe Pro Gly Lys Lys Leu Val Leu Ser Ser Glu 
            20                  25          


<210>  69
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.9

<400>  69

Gly Ile Pro Val Lys Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly 
1               5                   10                  15      


Val Leu Pro Leu Ser Trp Asp Ile Pro Glu 
            20                  25      


<210>  70
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.10

<400>  70

Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val Gly 
1               5                   10                  15      


Ser Leu Val Val Lys Ser Gly Gln Ser Glu 
            20                  25      


<210>  71
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.11

<400>  71

Asp Leu Val Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His 
1               5                   10                  15      


Ser Gly Ser Asp Met Val Gln Ala Glu 
            20                  25  


<210>  72
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.12

<400>  72

Lys Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val Thr Phe 
1               5                   10                  15      


Thr Ile Pro Ala Asn Arg Glu 
            20              


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.13

<400>  73

Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe Gly Thr Gln 
1               5                   10                  15      


Val Val Glu 
            


<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.14

<400>  74

Val Val Leu Ser Arg Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg 
1               5                   10                  15      


Ala Glu 
        


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.15

<400>  75

Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp Arg Ala His Glu 
1               5                   10                  15  


<210>  76
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.16

<400>  76

Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala Tyr Tyr Glu 
1               5                   10                  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.17

<400>  77

Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg Leu Glu 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.18

<400>  78

Asp Arg Gln Pro Val Pro Gly Gln Gln Met Thr Leu Lys Ile Glu 
1               5                   10                  15  


<210>  79
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.19

<400>  79

Val Thr Ile Thr Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu 
1               5                   10                  


<210>  80
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.20

<400>  80

Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp Gly Glu 
1               5                   10              


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.21

<400>  81

Lys Phe Tyr Tyr Ile Tyr Asn Glu 
1               5               


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.22

<400>  82

Asn Ser Pro Gln Gln Val Phe Ser Thr Glu 
1               5                   10  


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.23

<400>  83

Ser Leu Lys Arg Ile Pro Ile Glu 
1               5               


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.24

<400>  84

Tyr Val Leu Pro Ser Phe Glu 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.25

<400>  85

Gln Arg Ile Ser Leu Pro Glu 
1               5           


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.26

<400>  86

Leu Gln Cys Pro Gln Pro Ala Ala 
1               5               


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.27

<400>  87

Val Ile Val Glu Pro Thr Glu 
1               5           


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.28

<400>  88

Thr Met Val Leu Glu 
1               5   


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.29

<400>  89

Leu Arg Pro Gly Glu 
1               5   


<210>  90
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3.1.30

<400>  90

Phe Lys Ser Glu 
1               


<210>  91
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR1 peptide 2

<400>  91

Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Leu 
1               5                   10                  15      


Arg Thr Gly Glu 
            20  


<210>  92
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR2 peptide 3

<400>  92

Tyr Asn Phe Val Ser Pro Ser Lys Ser Phe Trp Thr Arg Ile Thr Cys 
1               5                   10                  15      


Ala Glu Glu 
            


<210>  93
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR3 peptide 2

<400>  93

Lys Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Arg Thr Cys Ser 
1               5                   10                  15      


Lys Ser Asp Ile Glu 
            20      


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR3 peptide 3

<400>  94

Asn Gly Tyr Asn Gln Asn Tyr Gly Arg Lys Phe Val Gln Gly Asn Ser 
1               5                   10                  15      


Thr Glu 
        


<210>  95
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR3 peptide 4

<400>  95

Gln Val Lys Pro Cys Asp Phe Pro Asp Ile Lys His Gly Gly Leu Phe 
1               5                   10                  15      


His Glu 
        


<210>  96
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR3 peptide 5

<400>  96

Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Ile Leu Ser Phe 
1               5                   10                  15      


Gln Ala Val Cys Arg Glu 
            20          


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR3 peptide 6

<400>  97

Tyr Gln Cys Gln Pro Tyr Tyr Glu 
1               5               


<210>  98
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR4 peptide 2

<400>  98

Asn Ser Arg Ala Lys Ser Asn Gly Met Arg Phe Lys Leu His Asp Thr 
1               5                   10                  15      


Leu Asp Tyr Glu 
            20  


<210>  99
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR4 peptide 3

<400>  99

Asp Gly Trp Ser His Phe Pro Thr Cys Tyr Asn Ser Ser Glu 
1               5                   10                  


<210>  100
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR4 peptide 4

<400>  100

Ile Ser Tyr Gly Asn Thr Thr Gly Ser Ile Val Cys Gly Glu 
1               5                   10                  


<210>  101
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR4 peptide 5

<400>  101

Phe Met Cys Lys Leu Gly Tyr Asn Ala Asn Thr Ser Val Leu Ser Phe 
1               5                   10                  15      


Gln Ala Val Cys Arg Glu 
            20          


<210>  102
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 2

<400>  102

Gly Thr Leu Cys Asp Phe Pro Lys Ile His His Gly Phe Leu Tyr Asp 
1               5                   10                  15      


Glu Glu 
        


<210>  103
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 3

<400>  103

Tyr Ala Met Ile Gly Asn Asn Met Ile Thr Cys Ile Asn Gly Ile Trp 
1               5                   10                  15      


Thr Glu 
        


<210>  104
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 4

<400>  104

Tyr Gly Tyr Val Gln Pro Ser Val Pro Pro Tyr Gln His Gly Val Ser 
1               5                   10                  15      


Val Glu 
        


<210>  105
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 5

<400>  105

Gly Asp Thr Val Gln Ile Ile Cys Asn Thr Gly Tyr Ser Leu Gln Asn 
1               5                   10                  15      


Asn Glu 
        


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 6

<400>  106

Ile Val Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Val Glu 
1               5                   10                  15      


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 7

<400>  107

Asp Tyr Asn Pro Phe Ser Gln Val Pro Thr Gly Glu 
1               5                   10          


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 8

<400>  108

Gln Val Lys Thr Cys Gly Tyr Ile Pro Glu 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 9

<400>  109

Ala Asn Val Asp Ala Gln Pro Lys Lys Glu 
1               5                   10  


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 10

<400>  110

Trp Thr Thr Leu Pro Thr Cys Val Glu 
1               5                   


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FHR5 peptide 11

<400>  111

Lys Val Ala Val Leu Cys Lys Glu 
1               5               


<210>  112
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 2

<400>  112

Ser Asn Thr Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly 
1               5                   10                  15      


Trp Ser Asp Leu Pro Ile Cys Tyr Glu 
            20                  25  


<210>  113
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 3

<400>  113

Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser 
1               5                   10                  15      


Lys Ser Ser Ile Asp Ile Glu 
            20              


<210>  114
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 4

<400>  114

Leu Pro Lys Ile Asp Val His Leu Val Pro Asp Arg Lys Lys Asp Gln 
1               5                   10                  15      


Tyr Lys Val Gly Glu 
            20      


<210>  115
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 5

<400>  115

Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
1               5                   10                  15      


Cys Val Asp Gly Glu 
            20      


<210>  116
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 6

<400>  116

Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser 
1               5                   10                  15      


Arg Thr Gly Glu 
            20  


<210>  117
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 7

<400>  117

Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
1               5                   10                  15      


Pro Ser Phe Glu 
            20  


<210>  118
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 8

<400>  118

His Gly Trp Ala Gln Leu Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser 
1               5                   10                  15      


Val Glu 
        


<210>  119
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 9

<400>  119

Ile Ser His Gly Val Val Ala His Met Ser Asp Ser Tyr Gln Tyr Gly 
1               5                   10                  15      


Glu Glu 
        


<210>  120
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 10

<400>  120

Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu 
1               5                   10                  15  


<210>  121
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 11

<400>  121

Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
1               5                   10                  15      


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 12

<400>  122

Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
1               5                   10                  15  


<210>  123
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 13

<400>  123

Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val Thr Ala Asp Gly Glu 
1               5                   10                  15      


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 14

<400>  124

Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu 
1               5                   10                  15  


<210>  125
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 15

<400>  125

Ser Tyr Ala His Gly Thr Lys Leu Ser Tyr Thr Cys Glu 
1               5                   10              


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 16

<400>  126

Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu 
1               5                   10      


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 17

<400>  127

Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
1               5                   10                  15  


<210>  128
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 18

<400>  128

His Gly Thr Ile Asn Ser Ser Arg Ser Ser Gln Glu 
1               5                   10          


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 19

<400>  129

Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu 
1               5                   10  


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 20

<400>  130

Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
1               5                   10      


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 21

<400>  131

Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu 
1               5                   10      


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 22

<400>  132

Ser Gln Tyr Thr Tyr Ala Leu Lys Glu 
1               5                   


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 23

<400>  133

Gln Val Gln Ser Cys Gly Pro Pro Pro Glu 
1               5                   10  


<210>  134
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 24

<400>  134

Lys Lys Asp Val Tyr Lys Ala Gly Glu 
1               5                   


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 25

<400>  135

Gly Leu Pro Cys Lys Ser Pro Pro Glu 
1               5                   


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 26

<400>  136

Lys Val Ser Val Leu Cys Gln Glu 
1               5               


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 27

<400>  137

His Leu Lys Asn Lys Lys Glu 
1               5           


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 28

<400>  138

Gly Gly Phe Arg Ile Ser Glu Glu 
1               5               


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 29

<400>  139

Leu Leu Asn Gly Asn Val Lys Glu 
1               5               


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 30

<400>  140

Tyr Pro Thr Cys Ala Lys Arg 
1               5           


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FH peptide 31

<400>  141

Ser Thr Cys Gly Asp Ile Pro Glu 
1               5               


<210>  142
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3dg

<400>  142

Glu Gly Val Gln Lys Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln 
1               5                   10                  15      


Val Pro Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro 
            20                  25                  30          


Val Ala Gln Met Thr Glu Asp Ala Val Asp Ala Glu Arg Leu Lys His 
        35                  40                  45              


Leu Ile Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly Met 
    50                  55                  60                  


Thr Pro Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln Trp 
65                  70                  75                  80  


Glu Lys Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile Lys 
                85                  90                  95      


Lys Gly Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala Phe 
            100                 105                 110         


Ala Ala Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr Val 
        115                 120                 125             


Val Lys Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser Gln 
    130                 135                 140                 


Val Leu Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys Pro 
145                 150                 155                 160 


Asp Gly Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met Ile 
                165                 170                 175     


Gly Gly Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala Phe 
            180                 185                 190         


Val Leu Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln Val 
        195                 200                 205             


Asn Ser Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu Ala 
    210                 215                 220                 


Asn Tyr Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly Tyr 
225                 230                 235                 240 


Ala Leu Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys Phe 
                245                 250                 255     


Leu Thr Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys Gln 
            260                 265                 270         


Leu Tyr Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu Gln 
        275                 280                 285             


Leu Lys Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn Glu 
    290                 295                 300                 


Gln Arg Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe Met 
305                 310                 315                 320 


Val Phe Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His Gln 
                325                 330                 335     


Glu Leu Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg 
            340                 345                 


<210>  143
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3g

<400>  143

Glu Gly Val Gln Lys Glu Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln 
1               5                   10                  15      


Val Pro Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro 
            20                  25                  30          


Val Ala Gln Met Thr Glu Asp Ala Val Asp Ala Glu Arg Leu Lys 
        35                  40                  45          


<210>  144
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3d

<400>  144

His Leu Ile Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly 
1               5                   10                  15      


Met Thr Pro Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln 
            20                  25                  30          


Trp Glu Lys Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile 
        35                  40                  45              


Lys Lys Gly Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala 
    50                  55                  60                  


Phe Ala Ala Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr 
65                  70                  75                  80  


Val Val Lys Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser 
                85                  90                  95      


Gln Val Leu Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys 
            100                 105                 110         


Pro Asp Gly Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met 
        115                 120                 125             


Ile Gly Gly Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala 
    130                 135                 140                 


Phe Val Leu Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln 
145                 150                 155                 160 


Val Asn Ser Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu 
                165                 170                 175     


Ala Asn Tyr Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly 
            180                 185                 190         


Tyr Ala Leu Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys 
        195                 200                 205             


Phe Leu Thr Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys 
    210                 215                 220                 


Gln Leu Tyr Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu 
225                 230                 235                 240 


Gln Leu Lys Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn 
                245                 250                 255     


Glu Gln Arg Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe 
            260                 265                 270         


Met Val Phe Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His 
        275                 280                 285             


Gln Glu Leu Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg 
    290                 295                 300         


<210>  145
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Receptor 1


<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (160)..(160)
<223>  Xaa can be any naturally occurring amino acid

<400>  145

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Xaa Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Xaa Gly Ser Xaa 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  146
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Receptor 1 CCPs 8-10

<400>  146

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  147
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Receptor 1 CCPs 15-17

<400>  147

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  148
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Receptor 1 CCPs 8-10 and 15-17

<400>  148

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu 
        195                 200                 205             


Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys 
    210                 215                 220                 


Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys 
225                 230                 235                 240 


Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys 
                245                 250                 255     


Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile 
            260                 265                 270         


Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly 
        275                 280                 285             


His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn 
    290                 295                 300                 


Thr Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys 
305                 310                 315                 320 


Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg 
                325                 330                 335     


Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly 
            340                 345                 350         


Ser Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr 
        355                 360                 365             


Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro 
    370                 375                 380                 


Gln Cys Ile Ile 
385             


<210>  149
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Factor I proteolytic domain

<400>  149

Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val 
1               5                   10                  15      


Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly 
            20                  25                  30          


Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr 
        35                  40                  45              


His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp 
    50                  55                  60                  


Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu 
65                  70                  75                  80  


Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met 
                85                  90                  95      


Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro 
            100                 105                 110         


Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys 
        115                 120                 125             


Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser 
    130                 135                 140                 


Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr 
145                 150                 155                 160 


Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp 
                165                 170                 175     


Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys 
            180                 185                 190         


Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly 
        195                 200                 205             


Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala 
    210                 215                 220                 


Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly 
225                 230                 235 


<210>  150
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Factor H co-factor region

<400>  150

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu 
                245     


<210>  151
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Receptor 1 CCPs 8-10

<400>  151

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  152
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Complement Receptor 1 CCPs 15-17

<400>  152

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  153
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GluC

<400>  153

Met Lys Gly Lys Phe Leu Lys Val Ser Ser Leu Phe Val Ala Thr Leu 
1               5                   10                  15      


Thr Thr Ala Thr Leu Val Ser Ser Pro Ala Ala Asn Ala Leu Ser Ser 
            20                  25                  30          


Lys Ala Met Asp Asn His Pro Gln Gln Thr Gln Ser Ser Lys Gln Gln 
        35                  40                  45              


Thr Pro Lys Ile Lys Lys Gly Gly Asn Leu Lys Pro Leu Glu Gln Arg 
    50                  55                  60                  


Glu His Ala Asn Val Ile Leu Pro Asn Asn Asp Arg His Gln Ile Thr 
65                  70                  75                  80  


Asp Thr Thr Asn Gly His Tyr Ala Pro Val Thr Tyr Ile Gln Val Glu 
                85                  90                  95      


Ala Pro Thr Gly Thr Phe Ile Ala Ser Gly Val Val Val Gly Lys Asp 
            100                 105                 110         


Thr Leu Leu Thr Asn Lys His Val Val Asp Ala Thr His Gly Asp Pro 
        115                 120                 125             


His Ala Leu Lys Ala Phe Pro Ser Ala Ile Asn Gln Asp Asn Tyr Pro 
    130                 135                 140                 


Asn Gly Gly Phe Thr Ala Glu Gln Ile Thr Lys Tyr Ser Gly Glu Gly 
145                 150                 155                 160 


Asp Leu Ala Ile Val Lys Phe Ser Pro Asn Glu Gln Asn Lys His Ile 
                165                 170                 175     


Gly Glu Val Val Lys Pro Ala Thr Met Ser Asn Asn Ala Glu Thr Gln 
            180                 185                 190         


Val Asn Gln Asn Ile Thr Val Thr Gly Tyr Pro Gly Asp Lys Pro Val 
        195                 200                 205             


Ala Thr Met Trp Glu Ser Lys Gly Lys Ile Thr Tyr Leu Lys Gly Glu 
    210                 215                 220                 


Ala Met Gln Tyr Asp Leu Ser Thr Thr Gly Gly Asn Ser Gly Ser Pro 
225                 230                 235                 240 


Val Phe Asn Glu Lys Asn Glu Val Ile Gly Ile His Trp Gly Gly Val 
                245                 250                 255     


Pro Asn Glu Phe Asn Gly Ala Val Phe Ile Asn Glu Asn Val Arg Asn 
            260                 265                 270         


Phe Leu Lys Gln Asn Ile Glu Asp Ile His Phe Ala Asn Asp Asp Gln 
        275                 280                 285             


Pro Asn Asn Pro Asp Asn Pro Asp Asn Pro Asn Asn Pro Asp Asn Pro 
    290                 295                 300                 


Asn Asn Pro Asp Asn Pro Asn Asn Pro Asp Glu Pro Asn Asn Pro Asp 
305                 310                 315                 320 


Asn Pro Asn Asn Pro Asp Asn Pro Asp Asn Gly Asp Asn Asn Asn Ser 
                325                 330                 335     


Asp Asn Pro Asp Ala Ala 
            340         


<210>  154
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GluC

<400>  154

Val Ile Leu Pro Asn Asn Asp Arg His Gln Ile Thr Asp Thr Thr Asn 
1               5                   10                  15      


Gly His Tyr Ala Pro Val Thr Tyr Ile Gln Val Glu Ala Pro Thr Gly 
            20                  25                  30          


Thr Phe Ile Ala Ser Gly Val Val Val Gly Lys Asp Thr Leu Leu Thr 
        35                  40                  45              


Asn Lys His Val Val Asp Ala Thr His Gly Asp Pro His Ala Leu Lys 
    50                  55                  60                  


Ala Phe Pro Ser Ala Ile Asn Gln Asp Asn Tyr Pro Asn Gly Gly Phe 
65                  70                  75                  80  


Thr Ala Glu Gln Ile Thr Lys Tyr Ser Gly Glu Gly Asp Leu Ala Ile 
                85                  90                  95      


Val Lys Phe Ser Pro Asn Glu Gln Asn Lys His Ile Gly Glu Val Val 
            100                 105                 110         


Lys Pro Ala Thr Met Ser Asn Asn Ala Glu Thr Gln Val Asn Gln Asn 
        115                 120                 125             


Ile Thr Val Thr Gly Tyr Pro Gly Asp Lys Pro Val Ala Thr Met Trp 
    130                 135                 140                 


Glu Ser Lys Gly Lys Ile Thr Tyr Leu Lys Gly Glu Ala Met Gln Tyr 
145                 150                 155                 160 


Asp Leu Ser Thr Thr Gly Gly Asn Ser Gly Ser Pro Val Phe Asn Glu 
                165                 170                 175     


Lys Asn Glu Val Ile Gly Ile His Trp Gly Gly Val Pro Asn Glu Phe 
            180                 185                 190         


Asn Gly Ala Val Phe Ile Asn Glu Asn Val Arg Asn Phe Leu Lys Gln 
        195                 200                 205             


Asn Ile Glu Asp Ile His Phe Ala Asn Asp Asp Gln Pro Asn Asn Pro 
    210                 215                 220                 


Asp Asn Pro Asp Asn Pro Asn Asn Pro Asp Asn Pro Asn Asn Pro Asp 
225                 230                 235                 240 


Asn Pro Asn Asn Pro Asp Glu Pro Asn Asn Pro Asp Asn Pro Asn Asn 
                245                 250                 255     


Pro Asp Asn Pro Asp Asn Gly Asp Asn Asn Asn Ser Asp Asn Pro Asp 
            260                 265                 270         


Ala Ala 
        


<210>  155
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FI peptide 24

<400>  155

Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu 
1               5                   10          


<210>  156
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3a-desArg

<400>  156

Leu Arg Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala 
1               5                   10                  


<210>  157
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C3f-desArg

<400>  157

Ser Ala Ser Leu Leu 
1               5   


<210>  158
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 1 (CFHR1, CFHR2)

<400>  158
gcuccugguc aguguaauuc u                                                 21


<210>  159
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 2 (CFHR1)

<400>  159
ggugagagag uacguuauga a                                                 21


<210>  160
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 3 (CFHR1)

<400>  160
gaauguagga gcccuuauga a                                                 21


<210>  161
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 4 (CFHR3)

<400>  161
guaccaaugc cagcccuacu a                                                 21


<210>  162
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 5 (CFHR3, CFHR4)

<400>  162
ggaaccacca agaugcauac a                                                 21


<210>  163
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 6 (CFHR3)

<400>  163
gcauaugguu agugagaagu u                                                 21


<210>  164
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 7 (CFHR4)

<400>  164
gaaucacacu ugguaacuaa u                                                 21


<210>  165
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 8 (CFHR4)

<400>  165
ggucaagagu cgaguaccag u                                                 21


<210>  166
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 9 (CFHR3, CFHR4)

<400>  166
gaaugcuacg auggauauga a                                                 21


<210>  167
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 10 (CFHR5)

<400>  167
gaaucuucag gacuaauaca u                                                 21


<210>  168
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 11 (CFHR5)

<400>  168
guaaauguuc ucgcuucagu a                                                 21


<210>  169
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 12 (CFH, CFHR1, CFHR2)

<400>  169
guaccaaugc cagaacuugu a                                                 21


<210>  170
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 13 (CFH, CFHR1)

<400>  170
gaggguaaca agcgaauaac a                                                 21


<210>  171
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 14 (CFH, CFHR1)

<400>  171
gguaacaagc gaauaacaug u                                                 21


<210>  172
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 15 (CFH, CFHR2)

<400>  172
gcuuuauuca agaacaggug a                                                 21


<210>  173
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 16 (CFHR2)

<400>  173
gaaaugucaa uuccuaacag u                                                 21


<210>  174
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 17 (CFHR3)

<400>  174
gugagaaguu gcaggguaag a                                                 21


<210>  175
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 18 (CFHR3)

<400>  175
guuuccccau accccacuca u                                                 21


<210>  176
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 19 (CFHR3)

<400>  176
gccaccaugu aagauguacc u                                                 21


<210>  177
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA target 20 (CFHR4)

<400>  177
ggauauaaug cgaauacauc a                                                 21


<210>  178
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 1

<400>  178
agaauuacac ugaccaggag c                                                 21


<210>  179
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 2

<400>  179
uucauaacgu acucucucac c                                                 21


<210>  180
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 3

<400>  180
uucauaaggg cuccuacauu c                                                 21


<210>  181
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 4

<400>  181
uaguagggcu ggcauuggua c                                                 21


<210>  182
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 5

<400>  182
uguaugcauc uuggugguuc c                                                 21


<210>  183
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 6

<400>  183
aacuucucac uaaccauaug c                                                 21


<210>  184
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 7

<400>  184
auuaguuacc aagugugauu c                                                 21


<210>  185
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 8

<400>  185
acugguacuc gacucuugac c                                                 21


<210>  186
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 9

<400>  186
uucauaucca ucguagcauu c                                                 21


<210>  187
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 10

<400>  187
auguauuagu ccugaagauu c                                                 21


<210>  188
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 11

<400>  188
uacugaagcg agaacauuua c                                                 21


<210>  189
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 12

<400>  189
uacaaguucu ggcauuggua c                                                 21


<210>  190
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 13

<400>  190
uguuauucgc uuguuacccu c                                                 21


<210>  191
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 14

<400>  191
acauguuauu cgcuuguuac c                                                 21


<210>  192
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 15

<400>  192
ucaccuguuc uugaauaaag c                                                 21


<210>  193
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 16

<400>  193
acuguuagga auugacauuu c                                                 21


<210>  194
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 17

<400>  194
ucuuacccug caacuucuca c                                                 21


<210>  195
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 18

<400>  195
augagugggg uauggggaaa c                                                 21


<210>  196
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 19

<400>  196
agguacaucu uacauggugg c                                                 21


<210>  197
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Antisense target 20

<400>  197
ugauguauuc gcauuauauc c                                                 21


<210>  198
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 1

<400>  198
gguugcauua ggcuauccuc u                                                 21


<210>  199
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 2

<400>  199
gaauaggguc ggaaguuaug a                                                 21


<210>  200
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 3

<400>  200
gugcauaacg guagauucag a                                                 21


<210>  201
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 4

<400>  201
gagccucacg cuacuaaccu a                                                 21


<210>  202
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 5

<400>  202
gaacaacacg gacgcucaau a                                                 21


<210>  203
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 6

<400>  203
gauugugaga gguucguaau a                                                 21


<210>  204
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 7

<400>  204
ggaauucuaa ucgaaacuac u                                                 21


<210>  205
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 8

<400>  205
ggucaaccgu aauggagguc a                                                 21


<210>  206
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 9

<400>  206
gaguuagagc gcauagaaua u                                                 21


<210>  207
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 10

<400>  207
gauccaaaug uaccgaauua u                                                 21


<210>  208
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 11

<400>  208
gaaauucuuc cgauugaguc u                                                 21


<210>  209
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 12

<400>  209
gaaagucacg auauccuguc a                                                 21


<210>  210
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 13

<400>  210
gagaaacaag aaggcguaac u                                                 21


<210>  211
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 14

<400>  211
ggaguacuua gcgaauaaac a                                                 21


<210>  212
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 15

<400>  212
gcaauuaguu aggacgauac u                                                 21


<210>  213
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 18

<400>  213
gucaacaucg cauagauauu a                                                 21


<210>  214
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 17

<400>  214
gaagcgaaug gguagguuag a                                                 21


<210>  215
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 18

<400>  215
gcucccuuuc cccuaaucac a                                                 21


<210>  216
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 19

<400>  216
ggaucacacu gccuacguaa u                                                 21


<210>  217
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Scramble antisense target 20

<400>  217
gaaagagacg auuauucaac u                                                 21


<210>  218
<211>  1297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens complement factor H related 1 (CFHR1), transcript 
       variant 1, mRNA

<400>  218
cagttagtac actgaaattc aaagtcatgc tcataactgt taatgaaagc agattcaaag       60

caacaccacc accactgaag tatttttagt tatataagat tggaactacc aagcatgtgg      120

ctcctggtca gtgtaattct aatctcacgg atatcctctg ttgggggaga agcaacattt      180

tgtgattttc caaaaataaa ccatggaatt ctatatgatg aagaaaaata taagccattt      240

tcccaggttc ctacagggga agttttctat tactcctgtg aatataattt tgtgtctcct      300

tcaaaatcat tttggactcg cataacatgc acagaagaag gatggtcacc aacaccaaag      360

tgtctcagac tgtgtttctt tccttttgtg gaaaatggtc attctgaatc ttcaggacaa      420

acacatctgg aaggtgatac tgtgcaaatt atttgcaaca caggatacag acttcaaaac      480

aatgagaaca acatttcatg tgtagaacgg ggctggtcca cccctcccaa atgcaggtcc      540

actgacactt cctgtgtgaa tccgcccaca gtacaaaatg ctcatatact gtcgagacag      600

atgagtaaat atccatctgg tgagagagta cgttatgaat gtaggagccc ttatgaaatg      660

tttggggatg aagaagtgat gtgtttaaat ggaaactgga cagaaccacc tcaatgcaaa      720

gattctacgg gaaaatgtgg gccccctcca cctattgaca atggggacat tacttcattc      780

ccgttgtcag tatatgctcc agcttcatca gttgagtacc aatgccagaa cttgtatcaa      840

cttgagggta acaagcgaat aacatgtaga aatggacaat ggtcagaacc accaaaatgc      900

ttacatccgt gtgtaatatc ccgagaaatt atggaaaatt ataacatagc attaaggtgg      960

acagccaaac agaagcttta tttgagaaca ggtgaatcag ctgaatttgt gtgtaaacgg     1020

ggatatcgtc tttcatcacg ttctcacaca ttgcgaacaa catgttggga tgggaaactg     1080

gagtatccaa cttgtgcaaa aagatagaat caatcataaa atgcacacct ttattcagaa     1140

ctttagtatt aaatcagttc ttaatttcat ttttaagtat tgttttactc ctttttattc     1200

atacgtaaaa ttttggatta atttgtgaaa atgtaattat aagctgagac cggtggctct     1260

cttcttaaaa gcaccatatt aaaacttgga aaactaa                              1297


<210>  219
<211>  1498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens complement factor H related 2 (CFHR2), transcript 
       variant 1, mRNA

<400>  219
accacaaagg actttactaa actagcttcc agttagtaca ctgaaattca aagtcatgct       60

cataactgtt aatgaaagca gattcaaagc aacaccacca ccactgaagt atttttagtt      120

atataagatt ggaactacca agcatgtggc tcctggtcag tgtaattcta atctcacgga      180

tatcctctgt tgggggagaa gcaatgttct gtgattttcc aaaaataaac catggaattc      240

tatatgatga agaaaaatat aagccatttt cccaagttcc tacaggggaa gttttctatt      300

actcctgtga atataatttt gtgtctcctt caaaatcctt ttggactcgc ataacgtgcg      360

cagaagaagg atggtcacca acaccaaagt gtctcagact gtgtttcttt ccttttgtgg      420

aaaatggtca ttctgaatct tcaggacaaa cacatctgga aggtgatact gtacaaatta      480

tttgcaacac aggatacaga cttcaaaaca atgagaacaa catttcatgt gtagaacggg      540

gctggtccac tcctcccaaa tgcaggtcca ctatttctgc agaaaaatgt gggccccctc      600

cacctattga caatggagac attacttcat tcctgttgtc agtatatgct ccaggttcat      660

cagttgagta ccagtgccag aacttgtatc aacttgaggg taacaatcaa ataacatgta      720

gaaacggaca atggtcagaa ccaccaaaat gcttagatcc atgtgtaata tcacaagaaa      780

ttatggaaaa atataacata aaattaaagt ggacaaacca acaaaagctt tattcaagaa      840

caggtgacat agttgaattt gtttgtaaat ctggatatca tccaacaaaa tctcattcat      900

ttcgagcaat gtgtcagaat gggaaactgg tatatcccag ttgtgaagaa aaatagaatc      960

aatggcatta ctattagtaa aatgcacacc tttttctgaa tttactatta tatttgtttt     1020

caatttcatt tttcaagtac tgttttactc atttttattc ataaataaag ttttgtgttg     1080

atttgtgaaa atgcaattac aatctgagat gtgtcacaat ggtgaggact atcttcacca     1140

aatctaagta acaacctagg aattgtcttt ttttttcttt ttaaaaaaat tgacaataac     1200

tgtatatatt catggagtac atagtaatgt ttccatatat ataatgtata atggtcagtt     1260

agggtaatta gtatatccat tatctcaaac atttttcatt tctttgggtt aggagcatta     1320

aatattctcc ttccagctat ttggtacttc atagtatatt actggtaact gaaggaatta     1380

tatctagacg ttaccccagg tatcttgaaa tgtcaattcc taacagtcac agcctgggag     1440

ctcatgtttg ccttctttca gagcttgtaa ctatgtatat ccacataaat aatcaaaa       1498


<210>  220
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens complement factor H related 3 (CFHR3), transcript 
       variant 1, mRNA

<400>  220
agtgcaactg aaacttttgt attagcatac tactgagaat atctaacatg ttgttactaa       60

tcaatgtcat tctgaccttg tgggtttcct gtgctaatgg acaagtgaaa ccttgtgatt      120

ttccagacat taaacatgga ggtctatttc atgagaatat gcgtagacca tactttccag      180

tagctgtagg aaaatattac tcctattact gtgatgaaca ttttgagact ccttcaggaa      240

gttactggga ttacattcat tgcacacaaa atgggtggtc accagcagta ccatgtctca      300

gaaaatgtta ttttccttat ttggaaaatg gatataatca aaattatgga agaaagtttg      360

tacagggtaa ctctacagaa gttgcctgcc atcctggcta cggtcttcca aaagcgcaga      420

ccacagttac atgtacggag aaaggctggt ctcctactcc cagatgcatc cgtgtcagaa      480

catgctcaaa atcagatata gaaattgaaa atggattcat ttccgaatct tcctctattt      540

atattttaaa taaagaaata caatataaat gtaaaccagg atatgcaaca gcagatggaa      600

attcttcagg atcaattaca tgtttgcaaa atggatggtc agcacaacca atttgcatta      660

attcttcaga aaagtgtggg cctcctccac ctattagcaa tggtgatacc acctcctttc      720

tactaaaagt gtatgtgcca cagtcaagag tcgagtacca atgccagccc tactatgaac      780

ttcagggttc taattatgta acatgtagta atggagagtg gtcggaacca ccaagatgca      840

tacatccatg tataataact gaagaaaaca tgaataaaaa taacataaag ttaaaaggaa      900

gaagtgacag aaaatattat gcaaaaacag gggataccat tgaatttatg tgtaaattgg      960

gatataatgc aaatacatca attctatcat ttcaagcagt gtgtcgggaa gggatagtgg     1020

aataccccag atgcgaataa ggcagcattg ttaccctaaa tgtatgtcca acttccactt     1080

ttccacttct cactcttatg gtctcaaagc ttgcaaagat agcttctgat attgttgtaa     1140

tttctacttt atttcaaaga aaattaatat aatagtttca atttgcaact taatatattc     1200

tcaaaaatat attaaaacaa actaaattat tgcttatgct tgtactaaaa taataaaaac     1260

tactcttata ttggacttct tatcaatgaa ttagtaagta tagagacaga cagctgaatg     1320

gctttctgca tattgtatag tatacctaga catagaaaca aaatgacttt agattttatt     1380

tggggaagta ataataccat aaaattagat attaaaattg taagtgaaga taaacacact     1440

atagtattcc cttattgtag ccatggtcct ctagatgcag ttaaccaaat agggtcattt     1500

ttattaaaag tagtgtttcc tggcaaacac tgacattaca tcattatcat gatttaaagg     1560

aaatagtact agagaaggtg aattattatc attttcctgt gaaaaaagaa aagaggtttt     1620

gctaaccctt tcagagcatt gggaacacag ccagaagtgc attaaatgta tatattaact     1680

tgggcaatgt tgacacttta ggatgctgaa gccaggtgca gtggcacacg cctgtaatcc     1740

tagcactttg agaggccaag ctggcaatca tcagaggtca aaagttcaag accagcctgt     1800

tcaacacggt gaaaccctgt ctctactaaa aatagaaaaa ctagctcggc atgatggcgt     1860

gcacctgtag tcccagctac tcaggaggct gaggtgggag aatcacttta accagtgggg     1920

cagaggttga actgagccaa gatagtgcca ctgcactcca gcctgggcaa tagagtgaga     1980

ctctgtctta aaaataaata aataggatgc tgaaaattcc tatttaagga aataattctt     2040

tttctgattt atttaaggct acatttgtat tttcttaata caaatatttt gaaagtttct     2100

tcatatatgg ttttttgcat ttcttattaa gttttgcttc agattttttt ttgtcttttc     2160

tcctgttaat tgccttcact ctctttctgt tctgtacttt tctttgtata taaggatttt     2220

ttgaaaagat tgtatatccc tgttaacaaa ttgaaatctc tattcacttt aatagatttt     2280

tacccccagt tagcatatgg ttagtgagaa gttgcagggt aagaagaaaa caatgttccc     2340

tttcccaaca cttttcctga ttatagagaa aaaagcatga acttgtataa tgatctagtc     2400

ctgtacagaa tgagaaatat taattgctag actgagaatg ttttggtggc taaagctagg     2460

aataactttt taagactgaa gaatgatata agctatcaaa tctaactcag ttttcaaata     2520

acaggtttgc agagactgga gaataaaaag taaaaaattg ttttattaat tccagtgact     2580

aattctactt catcaacata catcataaat aaaatttcaa aaataattgc tgatatggtt     2640

tggctgtgtc ccacccaatt ttcaccttga attatataat caccatgcat caaaggtagg     2700

gccaggtgga gataatggaa tcatgggagc agtttcccca taccccactc atggtagtaa     2760

atacatctca tgagatctaa tggttttata aatgaaagtt cccctggaca agttctcttg     2820

cctgccacca tgtaagatgt acctttgcta ctcattcacc ttctgtcatg atggtgaggc     2880

cttcccagca atgtggaact gtgagtccat taaacctctt tcctttataa atta           2934


<210>  221
<211>  2063
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens complement factor H related 4 (CFHR4), transcript 
       variant 1, mRNA

<400>  221
aaattcagaa tcacacttgg taactaataa tgaaagattt caaaccccaa acagtgcaac       60

tgaaactttt gcattactat actactgaga atatctaaca tgttgttact aatcaatgtc      120

attctgacct tgtgggtttc ctgtgctaat ggacaagaag tgaaaccttg tgattttcca      180

gaaattcaac atggaggtct atattataag agtttgcgta gactatactt tccagcagct      240

gcaggacaat cttattccta ttactgtgat caaaattttg tgactccttc aggaagttac      300

tgggattaca ttcattgcac acaagatggt tggtcaccaa cggtcccatg cctcagaaca      360

tgctcaaaat cagatgtaga aattgaaaat ggattcattt ctgaatcttc ctctatttat      420

attttaaatg aagaaacaca atataattgt aaaccaggat atgcaacagc agagggaaat      480

tcttcaggat caattacatg tttgcaaaat ggatggtcaa cacaaccaat ttgcattaaa      540

ttttgtgata tgcctgtttt tgagaattcc agagccaaga gtaatggcat gtggtttaag      600

ctccatgaca cattggacta tgaatgctat gatggatatg aaagcagtta tggaaacacc      660

acagattcca tagtgtgtgg tgaagatggc tggtcccatt tgccaacatg ctataattct      720

tcagaaaact gtgggcctcc tccacctatt agcaatggag ataccacgtc cttcccgcaa      780

aaagtgtatc tgccatggtc aagagtcgag taccagtgcc agtcctacta tgaacttcag      840

ggttctaaat atgtaacatg tagtaatgga gactggtcag aaccaccaag atgcatatca      900

atgaaacctt gtgagtttcc agaaattcaa catggacatc tatattatga gaatacgcgt      960

agaccatact ttccagtagc tacaggacaa tcttactcct attactgtga ccaaaatttt     1020

gtgactcctt caggaagtta ctgggattac attcactgca cacaagatgg gtggttgcca     1080

acagtcccat gcctcagaac atgctcaaaa tcagatatag aaattgaaaa tggattcatt     1140

tctgaatctt cctctattta tattttaaat aaagaaatac aatataaatg taaaccagga     1200

tatgcaacag cagatggaaa ttcttcaggt tcaattacat gtttgcaaaa tggatggtca     1260

gcacaaccaa tttgcattaa attttgtgat atgcctgttt ttgagaattc cagagccaag     1320

agtaatggca tgcggtttaa gctccatgac acattggact acgaatgcta cgatggatat     1380

gaaatcagtt atggaaacac cacaggttcc atagtgtgtg gtgaagatgg gtggtcccat     1440

ttcccaacat gttataattc ttcagaaaag tgtgggcctc ctccacctat tagcaatggt     1500

gataccacct cctttctact aaaagtgtat gtgccacagt caagagtcga gtaccaatgc     1560

cagtcctact atgaacttca gggttctaat tatgtaacat gtagtaatgg agagtggtcg     1620

gaaccaccaa gatgcataca tccatgtata ataactgaag aaaacatgaa taaaaataac     1680

atacagttaa aaggaaaaag tgacataaaa tattatgcaa aaacagggga taccattgaa     1740

tttatgtgta aattgggata taatgcgaat acatcagttc tatcatttca agcagtgtgt     1800

agggaaggca tagtggaata ccccagatgc gaataaggca gcattgttac cctaaatgta     1860

tgtccaactt ccacttctca ctcttatggt ctcaaagctt gcaaagatag cttctgatat     1920

tgttgtaatt tctactttat ttcaaagaaa attaatataa tagtttcaat ttgcaactta     1980

atatgttctc aaaaatatgt taaaacaaac taaattattg cttatgcttg tactaaaata     2040

ataaaaacta cccttatatt gga                                             2063


<210>  222
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens complement factor H related 5 (CFHR5), mRNA

<400>  222
agtacattga aattcaaagt catgcttgta actgttaatg aaagcagatt taaagcaaca       60

ccaccatcac tggagtattt ttagttatat acgattgaga ctaccaagca tgttgctctt      120

attcagtgta atcctaatct catgggtatc cactgttggg ggagaaggaa cactttgtga      180

ttttccaaaa atacaccatg gatttctgta tgatgaagaa gattataacc ctttttccca      240

agttcctaca ggggaagttt tctattactc ctgtgaatat aattttgtgt ctccttcaaa      300

atccttttgg actcgcataa catgcacaga agaaggatgg tcaccaacac cgaagtgtct      360

cagaatgtgt tcctttcctt ttgtgaaaaa tggtcattct gaatcttcag gactaataca      420

tctggaaggt gatactgtac aaattatttg caacacagga tacagccttc aaaacaatga      480

gaaaaacatt tcgtgtgtag aacggggctg gtccactcct cccatatgca gcttcactaa      540

aggagaatgt catgttccaa ttttagaagc caatgtagat gctcagccaa aaaaagaaag      600

ctacaaagtt ggagacgtgt tgaaattctc ctgcagaaaa aatcttataa gagttggatc      660

agactcagtt caatgttacc aatttgggtg gtcacctaac tttccaacat gcaaaggaca      720

agtacgatca tgtggtccac ctcctcaact ctccaatggt gaagttaagg agataagaaa      780

agaggaatat ggacacaatg aagtagtgga atatgattgc aatcctaatt ttataataaa      840

cgggcctaag aaaatacaat gtgtggatgg agaatggaca actttaccca cttgtgttga      900

acaagtgaaa acatgtggat acatacctga actcgagtac ggttatgttc agccgtctgt      960

ccctccctat caacatggag tttcagtcga ggtgaattgc agaaatgaat atgcaatgat     1020

tggaaataac atgattacct gtattaatgg aatatggaca gagcttccta tgtgtgttgc     1080

aacacaccaa cttaagaggt gcaaaatagc aggagttaat ataaaaacat tactcaagct     1140

atctgggaaa gaatttaatc ataattctag aatacgttac agatgttcag acatcttcag     1200

atacaggcac tcagtctgta taaacgggaa atggaatcct gaagtagact gcacagaaaa     1260

aagggaacaa ttctgcccac cgccacctca gatacctaat gctcagaata tgacaaccac     1320

agtgaattat caggatggag aaaaagtagc tgttctctgt aaagaaaact atctacttcc     1380

agaagcaaaa gaaattgtat gtaaagatgg acgatggcaa tcattaccac gctgtgttga     1440

gtctactgca tattgtgggc cccctccatc tattaacaat ggagatacca cctcattccc     1500

attatcagta tatcctccag ggtcaacagt gacgtaccgt tgccagtcct tctataaact     1560

ccagggctct gtaactgtaa catgcagaaa taaacagtgg tcagaaccac caagatgcct     1620

agatccatgt gtggtatctg aagaaaacat gaacaaaaat aacatacagt taaaatggag     1680

aaacgatgga aaactctatg caaaaacagg ggatgctgtt gaattccagt gtaaattccc     1740

acataaagcg atgatatcat caccaccatt tcgagcaatc tgtcaggaag ggaaatttga     1800

atatcctata tgtgaatgaa gcaagcataa ttttcctgaa tatattcttc aaacatccat     1860

ctatgctaaa agtagccatt atgtagccaa ttctgtagtt acttctttta ttctttcagg     1920

tgttgtttaa ctcagtttta tttagaactc tggattttta gagctttaga aatttgtaag     1980

ctgagagaac aatgtttcac ttaataggag ggtgtcttag tccatattac attgttataa     2040

cagagtatca cagactggat aacttctaac caatagttta tttgtttcat aaatctaaaa     2100

gctgagaagt ccaagatggt ggggctgcct ctggtgaggg tcttctcgaa gcatcataat     2160

atgctggaag gcatcacaac atggtggaag ggatcacgtg gcaaaagagc atgtacatgg     2220

gagtgagaga aaaagagaga gagagacaga gtggcggggg cggggaggag cgcaaactca     2280

tcctttataa agacaccact cctgagataa caatccaatc ccatgataat gacattaatc     2340

cattcaagaa gatagagctc tcgtgactta atcaccttct aaagatctca cctgacaaca     2400

ctgttgcatt ggcagttaag tttccacgta aactttcggg gacacattca aaccacagga     2460

gaaactcaaa ttgttcctgg gcaaatcaca acatggggaa ttttattcat aaatgtccac     2520

agaaacagta aatgttctcg cttcagtact taattcatct aatccctcct gtttgtctca     2580

aattatagga taactttgaa actttctgaa ttaacgttat ttaaaaggaa atgtagatgt     2640

tattttagtc tctatcttca tgttattatc acttaaaaac ctgcgaaagc tgtcaacttt     2700

tgtggttgta gcaagtatta ataaatattt ataaatcctc taatgtaagt ctagctacct     2760

atccaatact aaatacccct taaagtatta aatgcactat ctgctgtaaa agaa           2814


<210>  223
<211>  3962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens complement factor H (CFH), transcript variant 1, 
       mRNA

<400>  223
acaattcttg gaagaggaga actggacgtt gtgaacagag ttagctggta aatgtcctct       60

taaaagatcc aaaaaatgag acttctagca aagattattt gccttatgtt atgggctatt      120

tgtgtagcag aagattgcaa tgaacttcct ccaagaagaa atacagaaat tctgacaggt      180

tcctggtctg accaaacata tccagaaggc acccaggcta tctataaatg ccgccctgga      240

tatagatctc ttggaaatgt aataatggta tgcaggaagg gagaatgggt tgctcttaat      300

ccattaagga aatgtcagaa aaggccctgt ggacatcctg gagatactcc ttttggtact      360

tttaccctta caggaggaaa tgtgtttgaa tatggtgtaa aagctgtgta tacatgtaat      420

gaggggtatc aattgctagg tgagattaat taccgtgaat gtgacacaga tggatggacc      480

aatgatattc ctatatgtga agttgtgaag tgtttaccag tgacagcacc agagaatgga      540

aaaattgtca gtagtgcaat ggaaccagat cgggaatacc attttggaca agcagtacgg      600

tttgtatgta actcaggcta caagattgaa ggagatgaag aaatgcattg ttcagacgat      660

ggtttttgga gtaaagagaa accaaagtgt gtggaaattt catgcaaatc cccagatgtt      720

ataaatggat ctcctatatc tcagaagatt atttataagg agaatgaacg atttcaatat      780

aaatgtaaca tgggttatga atacagtgaa agaggagatg ctgtatgcac tgaatctgga      840

tggcgtccgt tgccttcatg tgaagaaaaa tcatgtgata atccttatat tccaaatggt      900

gactactcac ctttaaggat taaacacaga actggagatg aaatcacgta ccagtgtaga      960

aatggttttt atcctgcaac ccggggaaat acagcaaaat gcacaagtac tggctggata     1020

cctgctccga gatgtacctt gaaaccttgt gattatccag acattaaaca tggaggtcta     1080

tatcatgaga atatgcgtag accatacttt ccagtagctg taggaaaata ttactcctat     1140

tactgtgatg aacattttga gactccgtca ggaagttact gggatcacat tcattgcaca     1200

caagatggat ggtcgccagc agtaccatgc ctcagaaaat gttattttcc ttatttggaa     1260

aatggatata atcaaaatca tggaagaaag tttgtacagg gtaaatctat agacgttgcc     1320

tgccatcctg gctacgctct tccaaaagcg cagaccacag ttacatgtat ggagaatggc     1380

tggtctccta ctcccagatg catccgtgtc aaaacatgtt ccaaatcaag tatagatatt     1440

gagaatgggt ttatttctga atctcagtat acatatgcct taaaagaaaa agcgaaatat     1500

caatgcaaac taggatatgt aacagcagat ggtgaaacat caggatcaat tacatgtggg     1560

aaagatggat ggtcagctca acccacgtgc attaaatctt gtgatatccc agtatttatg     1620

aatgccagaa ctaaaaatga cttcacatgg tttaagctga atgacacatt ggactatgaa     1680

tgccatgatg gttatgaaag caatactgga agcaccactg gttccatagt gtgtggttac     1740

aatggttggt ctgatttacc catatgttat gaaagagaat gcgaacttcc taaaatagat     1800

gtacacttag ttcctgatcg caagaaagac cagtataaag ttggagaggt gttgaaattc     1860

tcctgcaaac caggatttac aatagttgga cctaattccg ttcagtgcta ccactttgga     1920

ttgtctcctg acctcccaat atgtaaagag caagtacaat catgtggtcc acctcctgaa     1980

ctcctcaatg ggaatgttaa ggaaaaaacg aaagaagaat atggacacag tgaagtggtg     2040

gaatattatt gcaatcctag atttctaatg aagggaccta ataaaattca atgtgttgat     2100

ggagagtgga caactttacc agtgtgtatt gtggaggaga gtacctgtgg agatatacct     2160

gaacttgaac atggctgggc ccagctttct tcccctcctt attactatgg agattcagtg     2220

gaattcaatt gctcagaatc atttacaatg attggacaca gatcaattac gtgtattcat     2280

ggagtatgga cccaacttcc ccagtgtgtg gcaatagata aacttaagaa gtgcaaatca     2340

tcaaatttaa ttatacttga ggaacattta aaaaacaaga aggaattcga tcataattct     2400

aacataaggt acagatgtag aggaaaagaa ggatggatac acacagtctg cataaatgga     2460

agatgggatc cagaagtgaa ctgctcaatg gcacaaatac aattatgccc acctccacct     2520

cagattccca attctcacaa tatgacaacc acactgaatt atcgggatgg agaaaaagta     2580

tctgttcttt gccaagaaaa ttatctaatt caggaaggag aagaaattac atgcaaagat     2640

ggaagatggc agtcaatacc actctgtgtt gaaaaaattc catgttcaca accacctcag     2700

atagaacacg gaaccattaa ttcatccagg tcttcacaag aaagttatgc acatgggact     2760

aaattgagtt atacttgtga gggtggtttc aggatatctg aagaaaatga aacaacatgc     2820

tacatgggaa aatggagttc tccacctcag tgtgaaggcc ttccttgtaa atctccacct     2880

gagatttctc atggtgttgt agctcacatg tcagacagtt atcagtatgg agaagaagtt     2940

acgtacaaat gttttgaagg ttttggaatt gatgggcctg caattgcaaa atgcttagga     3000

gaaaaatggt ctcaccctcc atcatgcata aaaacagatt gtctcagttt acctagcttt     3060

gaaaatgcca tacccatggg agagaagaag gatgtgtata aggcgggtga gcaagtgact     3120

tacacttgtg caacatatta caaaatggat ggagccagta atgtaacatg cattaatagc     3180

agatggacag gaaggccaac atgcagagac acctcctgtg tgaatccgcc cacagtacaa     3240

aatgcttata tagtgtcgag acagatgagt aaatatccat ctggtgagag agtacgttat     3300

caatgtagga gcccttatga aatgtttggg gatgaagaag tgatgtgttt aaatggaaac     3360

tggacggaac cacctcaatg caaagattct acaggaaaat gtgggccccc tccacctatt     3420

gacaatgggg acattacttc attcccgttg tcagtatatg ctccagcttc atcagttgag     3480

taccaatgcc agaacttgta tcaacttgag ggtaacaagc gaataacatg tagaaatgga     3540

caatggtcag aaccaccaaa atgcttacat ccgtgtgtaa tatcccgaga aattatggaa     3600

aattataaca tagcattaag gtggacagcc aaacagaagc tttattcgag aacaggtgaa     3660

tcagttgaat ttgtgtgtaa acggggatat cgtctttcat cacgttctca cacattgcga     3720

acaacatgtt gggatgggaa actggagtat ccaacttgtg caaaaagata gaatcaatca     3780

taaagtgcac acctttattc agaactttag tattaaatca gttctcaatt tcatttttta     3840

tgtattgttt tactcctttt tattcatacg taaaattttg gattaatttg tgaaaatgta     3900

attataagct gagaccggtg gctctcttct taaaagcacc atattaaatc ctggaaaact     3960

aa                                                                    3962


<210>  224
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guideRNA 1

<400>  224
agattagaat tacactgacc agg                                               23


<210>  225
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guideRNA 2

<400>  225
taatagaaaa cttcccctgt agg                                               23


<210>  226
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guideRNA 3

<400>  226
agacacaaaa ttatattcac agg                                               23


<210>  227
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  guideRNA 4

<400>  227
aatggtcatt ctgaatcttc agg                                               23


