                         SEQUENCE LISTING

<110>  INSERM
 
<120>  HEXOKINASE-DERIVED PEPTIDES AND THERAPEUTICAL USES THEREOF

<130>  BIO19187 TRICAUD

<160>  96    

<170>  PatentIn version 3.3

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:1


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X= Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= Ala, isomer-D Ala or Aib

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X= Phe, Leu or Tyr

<400>  1

Ala Gln Xaa Xaa Xaa Tyr Tyr Xaa 
1               5               


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:2


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  X= Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X= Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= Ala, isomer-D Ala or Aib

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X= Phe, Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X= Leu or Trp

<400>  2

Ala Gln Xaa Xaa Xaa Tyr Tyr Xaa Thr Glu Xaa Lys 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5i

<400>  3

Ala Gln Leu Leu Ala Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5j

<400>  4

Ala Gln Leu Leu Ala Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5k

<400>  5

Ala Gln Trp Leu Ala Tyr Tyr Phe Thr Glu Trp Lys 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5l

<400>  6

Ala Gln Trp Leu Ala Tyr Tyr Leu Thr Glu Leu Lys 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5m

<400>  7

Ala Gln Trp Leu Ala Tyr Tyr Tyr Thr Glu Leu Lys 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5n

<400>  8

Ala Gln Trp Leu Ala Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5o

<400>  9

Ala Gln Trp Leu Ala Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5p

<400>  10

Ala Gln Leu Trp Ala Tyr Tyr Phe Thr Glu Trp Lys 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5q

<400>  11

Ala Gln Leu Trp Ala Tyr Tyr Leu Thr Glu Leu Lys 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5r

<400>  12

Ala Gln Leu Trp Ala Tyr Tyr Tyr Thr Glu Leu Lys 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5s

<400>  13

Ala Gln Leu Trp Ala Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5t

<400>  14

Ala Gln Leu Trp Ala Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5u

<400>  15

Ala Gln Trp Trp Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5v

<400>  16

Ala Gln Trp Trp Ala Tyr Tyr Leu Thr Glu Leu Lys 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5w

<400>  17

Ala Gln Trp Trp Ala Tyr Tyr Tyr Thr Glu Leu Lys 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5x

<400>  18

Ala Gln Trp Trp Ala Tyr Tyr Phe Thr Glu Trp Lys 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5y

<400>  19

Ala Gln Trp Trp Ala Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5z

<400>  20

Ala Gln Trp Trp Ala Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6l


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  21

Xaa Ile Ala Ala Gln Trp Leu Ala Tyr Tyr Leu 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6m


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  22

Xaa Ile Ala Ala Gln Trp Leu Ala Tyr Tyr Tyr 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6n


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  23

Xaa Ile Ala Ala Gln Leu Trp Ala Tyr Tyr Leu 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6o


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  24

Xaa Ile Ala Ala Gln Leu Trp Ala Tyr Tyr Tyr 
1               5                   10      


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6p


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  25

Xaa Ile Ala Ala Gln Trp Trp Ala Tyr Tyr Phe 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6q


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  26

Xaa Ile Ala Ala Gln Trp Trp Ala Tyr Tyr Leu 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6r


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<400>  27

Xaa Ile Ala Ala Gln Trp Trp Ala Tyr Tyr Tyr 
1               5                   10      


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7a'


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  28

Ala Gln Leu Leu Xaa Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10          


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7g'


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  29

Ala Gln Trp Trp Xaa Tyr Tyr Phe Thr Glu Trp Lys 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5i-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  30

Ala Gln Leu Leu Xaa Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5j-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  31

Ala Gln Leu Leu Xaa Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5k-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  32

Ala Gln Trp Leu Xaa Tyr Tyr Phe Thr Glu Trp Lys 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5l-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  33

Ala Gln Trp Leu Xaa Tyr Tyr Leu Thr Glu Leu Lys 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5m-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  34

Ala Gln Trp Leu Xaa Tyr Tyr Tyr Thr Glu Leu Lys 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5n-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  35

Ala Gln Trp Leu Xaa Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5o-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  36

Ala Gln Trp Leu Xaa Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5p-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  37

Ala Gln Leu Trp Xaa Tyr Tyr Phe Thr Glu Trp Lys 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5q-U


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X=U

<400>  38

Ala Gln Leu Trp Xaa Tyr Tyr Leu Thr Glu Leu Lys 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5r-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  39

Ala Gln Leu Trp Xaa Tyr Tyr Tyr Thr Glu Leu Lys 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5s-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  40

Ala Gln Leu Trp Xaa Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5t-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  41

Ala Gln Leu Trp Xaa Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5u-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  42

Ala Gln Trp Trp Xaa Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5v-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  43

Ala Gln Trp Trp Xaa Tyr Tyr Leu Thr Glu Leu Lys 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5w-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  44

Ala Gln Trp Trp Xaa Tyr Tyr Tyr Thr Glu Leu Lys 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5y-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  45

Ala Gln Trp Trp Xaa Tyr Tyr Leu Thr Glu Trp Lys 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5z-U


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<400>  46

Ala Gln Trp Trp Xaa Tyr Tyr Tyr Thr Glu Trp Lys 
1               5                   10          


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6l-U


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<400>  47

Xaa Ile Ala Ala Gln Trp Leu Xaa Tyr Tyr Leu 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6m-U


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<400>  48

Xaa Ile Ala Ala Gln Trp Leu Xaa Tyr Tyr Tyr 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6n-U


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<400>  49

Xaa Ile Ala Ala Gln Leu Trp Xaa Tyr Tyr Leu 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6o-U


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<400>  50

Xaa Ile Ala Ala Gln Leu Trp Xaa Tyr Tyr Tyr 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6p-U


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<400>  51

Xaa Ile Ala Ala Gln Trp Trp Xaa Tyr Tyr Phe 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6q-U


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<400>  52

Xaa Ile Ala Ala Gln Trp Trp Xaa Tyr Tyr Leu 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6r-U


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<400>  53

Xaa Ile Ala Ala Gln Trp Trp Xaa Tyr Tyr Tyr 
1               5                   10      


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:54


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Aib

<400>  54

Ala Xaa Ala Xaa 
1               


<210>  55
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:55


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  55

Ala Xaa 
1       


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Penetratin

<400>  56

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R8

<400>  57

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tat

<400>  58

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  59
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transportan

<400>  59

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xentry

<400>  60

Leu Cys Leu Arg Pro Val Gly 
1               5           


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Horton Peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Cha

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Cha

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Cha

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Cha

<400>  61

Xaa Arg Xaa Arg Xaa Arg Xaa Arg 
1               5               


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1a

<400>  62

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1b

<400>  63

Ala Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1c

<400>  64

Leu Ala Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1d

<400>  65

Leu Ile Ala Ala Ala Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1e

<400>  66

Leu Ile Ala Ala Gln Leu Ala Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1f

<400>  67

Leu Ile Ala Ala Gln Leu Ala Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1g

<400>  68

Leu Ile Ala Ala Gln Leu Leu Ala Ala Tyr Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1h

<400>  69

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Ala Phe Thr Glu Leu Lys 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1i

<400>  70

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Ala Thr Glu Leu Lys 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1j

<400>  71

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Ala Glu Leu Lys 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1k

<400>  72

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Ala Leu Lys 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1l

<400>  73

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Ala Lys 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1m

<400>  74

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Ala 
1               5                   10                  15  


<210>  75
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3a

<400>  75

Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10                  


<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3b

<400>  76

Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10              


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3c

<400>  77

Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10          


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3d

<400>  78

Gln Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3e

<400>  79

Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10  


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3f

<400>  80

Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3g

<400>  81

Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5               


<210>  82
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4a

<400>  82

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu 
1               5                   10                  


<210>  83
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4b

<400>  83

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu 
1               5                   10              


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4c

<400>  84

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr 
1               5                   10          


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4d

<400>  85

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe 
1               5                   10      


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4e

<400>  86

Leu Ile Ala Ala Gln Leu Leu Ala Tyr Tyr 
1               5                   10  


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4f

<400>  87

Leu Ile Ala Ala Gln Leu Leu Ala Tyr 
1               5                   


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4g

<400>  88

Leu Ile Ala Ala Gln Leu Leu Ala 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:89

<400>  89

Ala Gln Leu Leu Ala Tyr Tyr Phe 
1               5               


<210>  90
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wt HK1 peptide

<400>  90

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Gly 
1               5                   10                  15      


Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
            20                  25              


<210>  91
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMT4G-mutated HK1 peptide

<400>  91

Met Gly Gln Ile Cys Gln Arg Glu Ser Ala Thr Ala Ala Glu Lys Gly 
1               5                   10                  15      


Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
            20                  25              


<210>  92
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Control peptide

<400>  92

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  93
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ile Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys Asp 
1               5                   10                  15      


Asp Gln Val Lys Lys Ile Asp Lys Tyr Leu Tyr Ala Met Arg Leu Ser 
            20                  25                  30          


Asp Glu Thr Leu Ile Asp Ile Met Thr Arg Phe Arg Lys Glu Met Lys 
        35                  40                  45              


Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr Ala Thr Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ser Ile Pro Asp Gly Ser Glu Lys Gly Asp Phe 
65                  70                  75                  80  


Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe Arg Ile Leu Arg Val Gln 
                85                  90                  95      


Val Asn His Glu Lys Asn Gln Asn Val His Met Glu Ser Glu Val Tyr 
            100                 105                 110         


Asp Thr Pro Glu Asn Ile Val His Gly Ser Gly Ser Gln Leu Phe Asp 
        115                 120                 125             


His Val Ala Glu Cys Leu Gly Asp Phe Met Glu Lys Arg Lys Ile Lys 
    130                 135                 140                 


Asp Lys Lys Leu Pro Val Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
145                 150                 155                 160 


Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr Trp Thr Lys Arg Phe Lys 
                165                 170                 175     


Ala Ser Gly Val Glu Gly Ala Asp Val Val Lys Leu Leu Asn Lys Ala 
            180                 185                 190         


Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn Ile Val Ala Val Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Gly Tyr Asp Asp Gln His Cys 
    210                 215                 220                 


Glu Val Gly Leu Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Glu Leu Arg His Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ser Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp Arg Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Val Ser Gly Met Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Val Lys Met Ala Lys Glu Gly Leu Leu Phe 
305                 310                 315                 320 


Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr Arg Gly Lys Phe Asn Thr 
                325                 330                 335     


Ser Asp Val Ser Ala Ile Glu Lys Asn Lys Glu Gly Leu His Asn Ala 
            340                 345                 350         


Lys Glu Ile Leu Thr Arg Leu Gly Val Glu Pro Ser Asp Asp Asp Cys 
        355                 360                 365             


Val Ser Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Val Ala Ala Thr Leu Gly Ala Ile Leu Asn Arg Leu Arg Asp Asn 
385                 390                 395                 400 


Lys Gly Thr Pro Arg Leu Arg Thr Thr Val Gly Val Asp Gly Ser Leu 
                405                 410                 415     


Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg Phe His Lys Thr Leu Arg 
            420                 425                 430         


Arg Leu Val Pro Asp Ser Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Gly Lys Gly Ala Ala Met Val Thr Ala Val Ala Tyr Arg Leu Ala 
    450                 455                 460                 


Glu Gln His Arg Gln Ile Glu Glu Thr Leu Ala His Phe His Leu Thr 
465                 470                 475                 480 


Lys Asp Met Leu Leu Glu Val Lys Lys Arg Met Arg Ala Glu Met Glu 
                485                 490                 495     


Leu Gly Leu Arg Lys Gln Thr His Asn Asn Ala Val Val Lys Met Leu 
            500                 505                 510         


Pro Ser Phe Val Arg Arg Thr Pro Asp Gly Thr Glu Asn Gly Asp Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Lys Lys Arg Thr Val Glu Met His Asn Lys Ile Tyr 
545                 550                 555                 560 


Ala Ile Pro Ile Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp 
                565                 570                 575     


His Ile Val Ser Cys Ile Ser Asp Phe Leu Asp Tyr Met Gly Ile Lys 
            580                 585                 590         


Gly Pro Arg Met Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Gln Gln 
        595                 600                 605             


Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr Trp Thr Lys Gly Phe Lys 
    610                 615                 620                 


Ala Thr Asp Cys Val Gly His Asp Val Val Thr Leu Leu Arg Asp Ala 
625                 630                 635                 640 


Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp Val Val Ala Val Val Asn 
                645                 650                 655     


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Glu Glu Pro Thr Cys 
            660                 665                 670         


Glu Val Gly Leu Ile Val Gly Thr Gly Ser Asn Ala Cys Tyr Met Glu 
        675                 680                 685             


Glu Met Lys Asn Val Glu Met Val Glu Gly Asp Gln Gly Gln Met Cys 
    690                 695                 700                 


Ile Asn Met Glu Trp Gly Ala Phe Gly Asp Asn Gly Cys Leu Asp Asp 
705                 710                 715                 720 


Ile Arg Thr His Tyr Asp Arg Leu Val Asn Glu Tyr Ser Leu Asn Ala 
                725                 730                 735     


Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser Gly Met Tyr Leu Gly Glu 
            740                 745                 750         


Ile Val Arg Asn Ile Leu Ile Asp Phe Thr Lys Lys Gly Phe Leu Phe 
        755                 760                 765             


Arg Gly Gln Ile Ser Glu Thr Met Lys Thr Arg Gly Ile Phe Glu Thr 
    770                 775                 780                 


Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val 
785                 790                 795                 800 


Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn Ser Thr Cys Asp Asp Ser 
                805                 810                 815     


Ile Leu Val Lys Thr Val Cys Gly Val Val Ser Arg Arg Ala Ala Gln 
            820                 825                 830         


Leu Cys Gly Ala Gly Met Ala Ala Val Val Asp Lys Ile Arg Glu Asn 
        835                 840                 845             


Arg Gly Leu Asp Arg Leu Asn Val Thr Val Gly Val Asp Gly Thr Leu 
    850                 855                 860                 


Tyr Lys Leu His Pro His Phe Ser Arg Ile Met His Gln Thr Val Lys 
865                 870                 875                 880 


Glu Leu Ser Pro Lys Cys Asn Val Ser Phe Leu Leu Ser Glu Asp Gly 
                885                 890                 895     


Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Gly Val Arg Leu Arg 
            900                 905                 910         


Thr Glu Ala Ser Ser 
        915         


<210>  94
<211>  923
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Gly Gln Ile Cys Gln Arg Glu Ser Ala Thr Ala Ala Glu Lys Pro 
1               5                   10                  15      


Lys Leu His Leu Leu Ala Glu Ser Glu His Cys Ile Asp Lys Tyr Leu 
            20                  25                  30          


Tyr Ala Met Arg Leu Ser Asp Glu Thr Leu Ile Asp Ile Met Thr Arg 
        35                  40                  45              


Phe Arg Lys Glu Met Lys Asn Gly Leu Ser Arg Asp Phe Asn Pro Thr 
    50                  55                  60                  


Ala Thr Val Lys Met Leu Pro Thr Phe Val Arg Ser Ile Pro Asp Gly 
65                  70                  75                  80  


Ser Glu Lys Gly Asp Phe Ile Ala Leu Asp Leu Gly Gly Ser Ser Phe 
                85                  90                  95      


Arg Ile Leu Arg Val Gln Val Asn His Glu Lys Asn Gln Asn Val His 
            100                 105                 110         


Met Glu Ser Glu Val Tyr Asp Thr Pro Glu Asn Ile Val His Gly Ser 
        115                 120                 125             


Gly Ser Gln Leu Phe Asp His Val Ala Glu Cys Leu Gly Asp Phe Met 
    130                 135                 140                 


Glu Lys Arg Lys Ile Lys Asp Lys Lys Leu Pro Val Gly Phe Thr Phe 
145                 150                 155                 160 


Ser Phe Pro Cys Gln Gln Ser Lys Ile Asp Glu Ala Ile Leu Ile Thr 
                165                 170                 175     


Trp Thr Lys Arg Phe Lys Ala Ser Gly Val Glu Gly Ala Asp Val Val 
            180                 185                 190         


Lys Leu Leu Asn Lys Ala Ile Lys Lys Arg Gly Asp Tyr Asp Ala Asn 
        195                 200                 205             


Ile Val Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Gly 
    210                 215                 220                 


Tyr Asp Asp Gln His Cys Glu Val Gly Leu Ile Ile Gly Thr Gly Thr 
225                 230                 235                 240 


Asn Ala Cys Tyr Met Glu Glu Leu Arg His Ile Asp Leu Val Glu Gly 
                245                 250                 255     


Asp Glu Gly Arg Met Cys Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp 
            260                 265                 270         


Asp Gly Ser Leu Glu Asp Ile Arg Thr Glu Phe Asp Arg Glu Ile Asp 
        275                 280                 285             


Arg Gly Ser Leu Asn Pro Gly Lys Gln Leu Phe Glu Lys Met Val Ser 
    290                 295                 300                 


Gly Met Tyr Leu Gly Glu Leu Val Arg Leu Ile Leu Val Lys Met Ala 
305                 310                 315                 320 


Lys Glu Gly Leu Leu Phe Glu Gly Arg Ile Thr Pro Glu Leu Leu Thr 
                325                 330                 335     


Arg Gly Lys Phe Asn Thr Ser Asp Val Ser Ala Ile Glu Lys Asn Lys 
            340                 345                 350         


Glu Gly Leu His Asn Ala Lys Glu Ile Leu Thr Arg Leu Gly Val Glu 
        355                 360                 365             


Pro Ser Asp Asp Asp Cys Val Ser Val Gln His Val Cys Thr Ile Val 
    370                 375                 380                 


Ser Phe Arg Ser Ala Asn Leu Val Ala Ala Thr Leu Gly Ala Ile Leu 
385                 390                 395                 400 


Asn Arg Leu Arg Asp Asn Lys Gly Thr Pro Arg Leu Arg Thr Thr Val 
                405                 410                 415     


Gly Val Asp Gly Ser Leu Tyr Lys Thr His Pro Gln Tyr Ser Arg Arg 
            420                 425                 430         


Phe His Lys Thr Leu Arg Arg Leu Val Pro Asp Ser Asp Val Arg Phe 
        435                 440                 445             


Leu Leu Ser Glu Ser Gly Ser Gly Lys Gly Ala Ala Met Val Thr Ala 
    450                 455                 460                 


Val Ala Tyr Arg Leu Ala Glu Gln His Arg Gln Ile Glu Glu Thr Leu 
465                 470                 475                 480 


Ala His Phe His Leu Thr Lys Asp Met Leu Leu Glu Val Lys Lys Arg 
                485                 490                 495     


Met Arg Ala Glu Met Glu Leu Gly Leu Arg Lys Gln Thr His Asn Asn 
            500                 505                 510         


Ala Val Val Lys Met Leu Pro Ser Phe Val Arg Arg Thr Pro Asp Gly 
        515                 520                 525             


Thr Glu Asn Gly Asp Phe Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe 
    530                 535                 540                 


Arg Val Leu Leu Val Lys Ile Arg Ser Gly Lys Lys Arg Thr Val Glu 
545                 550                 555                 560 


Met His Asn Lys Ile Tyr Ala Ile Pro Ile Glu Ile Met Gln Gly Thr 
                565                 570                 575     


Gly Glu Glu Leu Phe Asp His Ile Val Ser Cys Ile Ser Asp Phe Leu 
            580                 585                 590         


Asp Tyr Met Gly Ile Lys Gly Pro Arg Met Pro Leu Gly Phe Thr Phe 
        595                 600                 605             


Ser Phe Pro Cys Gln Gln Thr Ser Leu Asp Ala Gly Ile Leu Ile Thr 
    610                 615                 620                 


Trp Thr Lys Gly Phe Lys Ala Thr Asp Cys Val Gly His Asp Val Val 
625                 630                 635                 640 


Thr Leu Leu Arg Asp Ala Ile Lys Arg Arg Glu Glu Phe Asp Leu Asp 
                645                 650                 655     


Val Val Ala Val Val Asn Asp Thr Val Gly Thr Met Met Thr Cys Ala 
            660                 665                 670         


Tyr Glu Glu Pro Thr Cys Glu Val Gly Leu Ile Val Gly Thr Gly Ser 
        675                 680                 685             


Asn Ala Cys Tyr Met Glu Glu Met Lys Asn Val Glu Met Val Glu Gly 
    690                 695                 700                 


Asp Gln Gly Gln Met Cys Ile Asn Met Glu Trp Gly Ala Phe Gly Asp 
705                 710                 715                 720 


Asn Gly Cys Leu Asp Asp Ile Arg Thr His Tyr Asp Arg Leu Val Asn 
                725                 730                 735     


Glu Tyr Ser Leu Asn Ala Gly Lys Gln Arg Tyr Glu Lys Met Ile Ser 
            740                 745                 750         


Gly Met Tyr Leu Gly Glu Ile Val Arg Asn Ile Leu Ile Asp Phe Thr 
        755                 760                 765             


Lys Lys Gly Phe Leu Phe Arg Gly Gln Ile Ser Glu Thr Met Lys Thr 
    770                 775                 780                 


Arg Gly Ile Phe Glu Thr Lys Phe Leu Ser Gln Ile Glu Ser Asp Arg 
785                 790                 795                 800 


Leu Ala Leu Leu Gln Val Arg Ala Ile Leu Gln Gln Leu Gly Leu Asn 
                805                 810                 815     


Ser Thr Cys Asp Asp Ser Ile Leu Val Lys Thr Val Cys Gly Val Val 
            820                 825                 830         


Ser Arg Arg Ala Ala Gln Leu Cys Gly Ala Gly Met Ala Ala Val Val 
        835                 840                 845             


Asp Lys Ile Arg Glu Asn Arg Gly Leu Asp Arg Leu Asn Val Thr Val 
    850                 855                 860                 


Gly Val Asp Gly Thr Leu Tyr Lys Leu His Pro His Phe Ser Arg Ile 
865                 870                 875                 880 


Met His Gln Thr Val Lys Glu Leu Ser Pro Lys Cys Asn Val Ser Phe 
                885                 890                 895     


Leu Leu Ser Glu Asp Gly Ser Gly Lys Gly Ala Ala Leu Ile Thr Ala 
            900                 905                 910         


Val Gly Val Arg Leu Arg Thr Glu Ala Ser Ser 
        915                 920             


<210>  95
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  95

Ala Gln Leu Leu Ala Tyr Tyr Phe 
1               5               


<210>  96
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Ala Gln Leu Leu Ala Tyr Tyr Phe Thr Glu Leu Lys 
1               5                   10              


