               SEQUENCE LISTING

<110> ADOCIA

<120> COMPOSITIONS COMPRISING SHORT-ACTING HORMONES FOR TREATING OR PREVENTING OBESITY AND PUMPS COMPRISING SAID COMPOSITION

<130> B1639 F112

<140> EPPCT/2022/063941
<141> 2022-05-23

<150> EP21215775.4
<151> 2021-12-17
<150> EP21195161.1
<151> 2021-09-06
<150> EP21175483.3
<151> 2021-05-22

<160> 54

<170> BiSSAP 1.3.6

<210> 1
<211> 37
<212> PRT
<213> Homo sapiens


<220> 
<223> Human Amylin

<220> 
<221> DISULFID
<222> 2.7

<400> 1
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      
Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          
Gly Ser Asn Thr Tyr 
        35          

<210> 2
<211> 37
<212> PRT
<213> Artificial Sequence


<220> 
<223> Pramlintide

<400> 2
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      
Val His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          
Gly Ser Asn Thr Tyr 
        35          

<210> 3
<400> 3
000

<210> 4
<400> 4
000

<210> 5
<400> 5
000

<210> 6
<400> 6
000

<210> 7
<400> 7
000

<210> 8
<400> 8
000

<210> 9
<400> 9
000

<210> 10
<400> 10
000

<210> 11
<400> 11
000

<210> 12
<211> 37
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 5

<220> 
<221> MOD_RES
<222> 37
<223> The C-terminal carboxyl group is in the amide form.

<400> 12
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Glu Phe Leu 
1               5                   10                  15      
Arg His Ser Ser Asn Asn Phe Gly Pro Ile Leu Pro Pro Thr Asn Val 
            20                  25                  30          
Gly Ser Asn Thr Pro 
        35          

<210> 13
<400> 13
000

<210> 14
<400> 14
000

<210> 15
<400> 15
000

<210> 16
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 6

<220> 
<221> MOD_RES
<222> 33
<223> The C-terminal carboxyl group is in the amide form.

<400> 16
Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
1               5                   10                  15      
Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Pro Glu Ser 
            20                  25                  30          
Pro 
    

<210> 17
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA 2

<400> 17
Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
1               5                   10                  15      
Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Pro Glu Ser 
            20                  25                  30          
Pro 
    

<210> 18
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA 3

<220> 
<221> MOD_RES
<222> 33
<223> The C-terminal carboxyl group is in the amide form.

<400> 18
Glu Ala Ser Glu Leu Ser Thr Ala Ala Leu Gly Arg Leu Ser Ala Glu 
1               5                   10                  15      
Leu His Glu Leu Ala Thr Leu Pro Arg Thr Glu Thr Gly Pro Glu Ser 
            20                  25                  30          
Pro 
    

<210> 19
<400> 19
000

<210> 20
<400> 20
000

<210> 21
<400> 21
000

<210> 22
<400> 22
000

<210> 23
<400> 23
000

<210> 24
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 7

<220> 
<221> DISULFID
<222> 2..7

<220> 
<221> MOD_RES
<222> 22
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 35
<223> The C-terminal carboxyl group is in the amide form.

<400> 24
Arg Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Glu Phe Leu 
1               5                   10                  15      
His Arg Ser Ser Phe Gly Ala Ile Leu Ser Ser Thr Glu Val Gly Ser 
            20                  25                  30          
Glu Thr Pro 
        35  

<210> 25
<211> 37
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 8

<220> 
<221> DISULFID
<222> 2..7

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 26
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 37
<223> The C-terminal carboxyl group is in the amide form.

<400> 25
Arg Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Glu Phe Leu 
1               5                   10                  15      
His Arg Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          
Gly Ser Asn Thr Pro 
        35          

<210> 26
<400> 26
000

<210> 27
<400> 27
000

<210> 28
<400> 28
000

<210> 29
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd9

<220> 
<221> DISULFID
<222> 2..7

<220> 
<221> MOD_RES
<222> 22
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 35
<223> The C-terminal carboxyl group is in the amide form.

<220> 
<221> VARIANT
<222> 35
<223> Xaa35 is Hyp

<400> 29
Arg Cys Gly Thr Ala Thr Cys Ala Thr Glu Arg Leu Ala His Phe Leu 
1               5                   10                  15      
Gln Arg Ser Ser Phe Gly Ala Ile Leu Ser Ser Thr Glu Val Gly Ser 
            20                  25                  30          
Asn Thr Xaa 
        35  

<210> 30
<400> 30
000

<210> 31
<400> 31
000

<210> 32
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 10

<220> 
<221> STRAND
<222> 2..7
<223> Xaa2 and Xaa7 are amino acid residues whose side chains together
      form a lactam bridge

<220> 
<221> MOD_RES
<222> 22
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 35
<223> The C-terminal carboxyl group is in the amide form.

<220> 
<221> VARIANT
<222> 35
<223> Xaa35 is Hyp

<400> 32
Arg Asp Gly Thr Ala Thr Lys Ala Thr Gln Arg Leu Ala Asp Phe Leu 
1               5                   10                  15      
Gln Arg Ser Ser Phe Gly Ala Ile Leu Ser Ser Thr Glu Val Gly Ser 
            20                  25                  30          
Asn Thr Xaa 
        35  

<210> 33
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 11

<220> 
<221> STRAND
<222> 2..7
<223> Xaa2 and Xaa7 are amino acid residues whose side chains together
      form a lactam bridge

<220> 
<221> VARIANT
<222> 14
<223> Xaa14 is Aad

<220> 
<221> MOD_RES
<222> 22
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 35
<223> The C-terminal carboxyl group is in the amide form.

<220> 
<221> VARIANT
<222> 35
<223> Xaa35 is Hyp

<400> 33
Arg Asp Gly Thr Ala Thr Lys Ala Thr Glu Arg Leu Ala Xaa Phe Leu 
1               5                   10                  15      
Gln Arg Ser Ser Phe Gly Ala Ile Leu Ser Ser Thr Glu Val Gly Ser 
            20                  25                  30          
Asn Thr Xaa 
        35  

<210> 34
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 12

<220> 
<221> STRAND
<222> 2..7
<223> Xaa2 and Xaa7 are amino acid residues whose side chains together
      form a lactam bridge

<220> 
<221> VARIANT
<222> 14
<223> Xaa14 is Aad

<220> 
<221> MOD_RES
<222> 22
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 35
<223> The C-terminal carboxyl group is in the amide form.

<220> 
<221> VARIANT
<222> 35
<223> Xaa35 is Hyp

<400> 34
Arg Asp Gly Thr Ala Thr Lys Ala Thr Glu Arg Leu Ala Xaa Phe Leu 
1               5                   10                  15      
Gln Arg Thr Thr Phe Gly Ala Ile Leu Ser Ser Thr Glu Val Gly Ser 
            20                  25                  30          
Asn Thr Xaa 
        35  

<210> 35
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 13

<220> 
<221> STRAND
<222> 2..7
<223> Xaa2 and Xaa7 are amino acid residues whose side chains together
      form a lactam bridge

<220> 
<221> MOD_RES
<222> 22
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 35
<223> The C-terminal carboxyl group is in the amide form.

<220> 
<221> VARIANT
<222> 35
<223> Xaa35 is Hyp

<400> 35
Arg Asp Gly Thr Ala Thr Lys Ala Thr Glu Arg Leu Ala His Phe Leu 
1               5                   10                  15      
Gln Arg Ser Ser Phe Gly Ala Ile Leu Ser Ser Thr Glu Val Gly Ser 
            20                  25                  30          
Asn Thr Xaa 
        35  

<210> 36
<211> 35
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amylin RA Cpd 14

<220> 
<221> STRAND
<222> 2..7
<223> Xaa2 and Xaa7 are amino acid residues whose side chains together
      form a lactam bridge

<220> 
<221> VARIANT
<222> 14
<223> Xaa14 is Aad

<220> 
<221> MOD_RES
<222> 22
<223> METHYLATION MeGly

<220> 
<221> MOD_RES
<222> 24
<223> METHYLATION MeIle

<220> 
<221> MOD_RES
<222> 35
<223> The C-terminal carboxyl group is in the amide form.

<220> 
<221> VARIANT
<222> 35
<223> Xaa35 is Hyp

<400> 36
Lys Asp Gly Thr Ala Thr Lys Ala Thr Gln Arg Leu Ala Xaa Phe Leu 
1               5                   10                  15      
Gln Arg Ser Ser Phe Gly Ala Ile Leu Ser Ser Thr Glu Val Gly Ser 
            20                  25                  30          
Asn Thr Xaa 
        35  

<210> 37
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> Exenatide

<400> 37
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          
Ser Gly Ala Pro Pro Pro Ser 
        35                  

<210> 38
<211> 44
<212> PRT
<213> Artificial Sequence


<220> 
<223> Lixisenatide

<220> 
<221> MOD_RES
<222> 44
<223> The C-terminal carboxyl group is in the amide form.

<400> 38
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      
Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          
Ser Gly Ala Pro Pro Ser Lys Lys Lys Lys Lys Lys 
        35                  40                  

<210> 39
<211> 29
<212> PRT
<213> Homo sapiens


<220> 
<223> Human Glucagon

<400> 39
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  

<210> 40
<211> 29
<212> PRT
<213> Artificial Sequence


<220> 
<223> Dasiglucagon

<220> 
<221> VARIANT
<222> 16
<223> Xaa16 is Aib

<400> 40
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      
Ala Arg Ala Glu Glu Phe Val Lys Trp Leu Glu Ser Thr 
            20                  25                  

<210> 41
<400> 41
000

<210> 42
<400> 42
000

<210> 43
<400> 43
000

<210> 44
<400> 44
000

<210> 45
<400> 45
000

<210> 46
<400> 46
000

<210> 47
<400> 47
000

<210> 48
<400> 48
000

<210> 49
<400> 49
000

<210> 50
<400> 50
000

<210> 51
<400> 51
000

<210> 52
<211> 36
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide PYY (1-36)

<400> 52
Tyr Pro Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu 
1               5                   10                  15      
Leu Asn Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr 
            20                  25                  30          
Arg Gln Arg Tyr 
        35      

<210> 53
<211> 34
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide PYY (3-36)

<400> 53
Ile Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Asn 
1               5                   10                  15      
Arg Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln 
            20                  25                  30          
Arg Tyr 
        

<210> 54
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide PYY (4-36)

<400> 54
Lys Pro Glu Ala Pro Gly Glu Asp Ala Ser Pro Glu Glu Leu Asn Arg 
1               5                   10                  15      
Tyr Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln Arg 
            20                  25                  30          
Tyr 
    

