                         SEQUENCE LISTING

<110>  Shanghai CirCode Biomed Co., Ltd.
 
<120>  CONSTRUCTS AND METHODS FOR PREPARING CIRCULAR RNAS AND USE 
       THEREOF

<130>  S2901CCD33WO

<150>  CN202110594352.4
<151>  2021-05-28

<160>  134   

<170>  PatentIn version 3.5

<210>  1
<211>  989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' arm of target sequence

<400>  1
caaaggctta cctatcacta gcgcgacacg ttcctaagtg aaaagcttag gcactgtcga       60

actcaacagt tcagcagtga actgtcattc taagaagtca aatgaaggag taacgtctgg      120

aagggcttcc cttaatcctc cgacatgcag gaaagtaggc aagtactgaa ctgtgtgaag      180

ctcggtgaag tcggttgaag gttaccgtaa attagtatct ctaatacgaa agctatccag      240

cggtggatgg tgtaactgat agaccggagg tctataaaac actcaaggtt aggatgcgcg      300

atgaactaga ggcgatcgct agtaagcgca gacgaatccc tgatggtacg ggtctatatc      360

gggagggaat cgaaaggttc tctgacacaa ataagtgtcg ctactgtggg tgagtaaaac      420

tctcctttat gaaagcccat atatcgttac aggcgttatt aaggtagcag gctcataggg      480

gaaacctaaa agtgtatgta cagataagaa tgacggaacg tggtaagctg ccgacatgga      540

gggcttgttc tctttgaagt gttgccaagg aaagtcacaa tgagattagt tgtcgatata      600

acttggttta acggcagtga aagtggtggc acagtaccga tgaaacgtgt aatgaacgtg      660

gagggatagc cactagtcga ttgaagattg aaggttacta ttggttaaca tggtttcgag      720

taagactaag agatgtaatg ctccaaagta ataaggaggt tacagcccat gttaaagaaa      780

accaagctaa gacataacga atattatgat acacaaaaaa agtgtatgac aatttatact      840

cgaacagtct taacggtaac aatttctttc aattggaaac gatggaacgc cgtatgcccg      900

gaaacgggcg cgtacggtgt ggagtggggg aaaagctgga gataatctca aaggcttacc      960

tatcactatc gcgacacgtt cctaagtga                                        989


<210>  2
<211>  1028
<212>  DNA
<213>  Clostridium tetani

<400>  2
gccatacaat aaaagtgcga aacgttatcc tataagtaag aaagttttaa aattttctta       60

cgaaaaggat agaacttaaa agttctaact gttctactaa agtaataagt gaaaatctta      120

tttaaagcaa acaaccaagt agctttaagt ctaagtcccc tacacaagtt ttatactact      180

atgcaaaact tgtgaagcta ggtaaggtcg taatccgtga aagtcggatg cggggctcct      240

taaaagatta ctatggtaaa cataagctaa tccattaaga tgcgatttat atgtatttta      300

tactgttaaa tatttttgtg cttgtggctt ggtataaaac agttaagatg aagtacttaa      360

ctggttttgg aataattggt tgttaaacta aaacattata aatcgttagt ggatacctaa      420

ggtaatcaaa aatagggata ggtagaatgg aacgtttgat gctgtatatg aagaggttta      480

gtagaaccta ggacacatat acgggctcag caggttcata gtagctatga tactcagccg      540

gaagtcaatt aattttgaaa tacttctatg gtaacatagg agaaggataa aactgagtga      600

gccaaggaac ctagtcggta atagaaaagt ggaagttaaa acaaatataa gattttagaa      660

ttaatttaat taatgaacgg aattaattta atgatattta aagttagacg gttataaatt      720

aaacatttca aaattaaacc atatccaaat tcataaatat agctagatca tatcactagt      780

ttaaaaataa ataaatcatt tcaaattact attaagtaag gtattaatac cttacttaat      840

agtaatctca ttacataaga gaattactag attagcagac agattcataa aaactatatc      900

aactaggaca atagaaaata tatttataca cttcctatta tcgagcgaac gccttatgcg      960

atgaaagtcg cacgtagggt gtagaccaag cgaaatccta tgcatttagg atagtgaggt     1020

atagcaaa                                                              1028


<210>  3
<211>  1028
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Group II intron Cte_mut

<400>  3
gcaagacaat aaaagtttga cacgtgatcc tataagtaag aaagttttaa aattttctta       60

cgaaaaggat agaacttaaa agttctaact gttctactaa agtaataagt gaaaatctta      120

tttaaagcaa acaaccaagt agctttaagt ctaagtcccc tacacaagtt ttatactact      180

atgcaaaact tgtgaagcta ggtaaggtcg taatccgtga aagtcggatg cggggctcct      240

taaaagatta ctatggtaaa cataagctaa tccattaaga tgcgatttat atgtatttta      300

tactgttaaa tatttttgtg cttgtggctt ggtataaaac agttaagatg aagtacttaa      360

ctggttttgg aataattggt tgttaaacta aaacattata aatcgttagt ggatacctaa      420

ggtaatcaaa aatagggata ggtagaatgg aacgtttgat gctgtatatg aagaggttta      480

gtagaaccta ggacacatat acgggctcag caggttcata gtagctatga tactcagccg      540

gaagtcaatt aattttgaaa tacttctatg gtaacatagg agaaggataa aactgagtga      600

gccaaggaac ctagtcggta atagaaaagt ggaagttaaa acaaatataa gattttagaa      660

ttaatttaat taatgaacgg aattaattta atgatattta aagttagacg gttataaatt      720

aaacatttca aaattaaacc atatccaaat tcataaatat agctagatca tatcactagt      780

ttaaaaataa ataaatcatt tcaaattact attaagtaag gtattaatac cttacttaat      840

agtaatctca ttacataaga gaattactag attagcagac agattcataa aaactatatc      900

aactaggaca atagaaaata tatttataca cttcctatta tcgagcgaac gccttatgcg      960

atgaaagtcg cacgtagggt gtagaccaag cgaaatccta tgcatttagg atagtgaggt     1020

atagcaaa                                                              1028


<210>  4
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence1

<400>  4
gcaatagccg aaaaacaaaa aacaaaaaaa acaaaaaaaa aaccaaaaaa acaaaacaca       60


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence2

<400>  5
aaattataat aattataata                                                   20


<210>  6
<211>  224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence3

<400>  6
atgaaaccgg ctcggattcc gcccgcgtgc gccatcccct cagctagcag gtgtgagcgg       60

ctttctgccc gcagtctcta cacagctcag catcctgacg cctcctcccc ttgcaggggc      120

gtgaagctac ttcagactct gctgtgacga cttggccgcc aggcaccgat cctccccggt      180

gagaaggtcc acgaatctta ctgcagacag atttgctcag cgcg                       224


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe1

<400>  7
ctttcactac tcctacgagc acca                                              24


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Probe2

<400>  8
gaccatgctc ccaagcaaga tcatg                                             25


<210>  9
<211>  555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gluc

<400>  9
atgggagtca aagttctgtt tgccctgatc tgcatcgctg tggccgaggc caagcccacc       60

gagaacaacg aagacttcaa catcgtggcc gtggccagca acttcgcgac cacggatctc      120

gatgctgacc gcgggaagtt gcccggcaag aagctgccgc tggaggtgct caaagagatg      180

gaagccaatg cccggaaagc tggctgcacc aggggctgtc tgatctgcct gtcccacatc      240

aagtgcacgc ccaagatgaa gaagttcatc ccaggacgct gccacaccta cgaaggcgac      300

aaagagtccg cacagggcgg cataggcgag gcgatcgtcg acattcctga gattcctggg      360

ttcaaggact tggagcccat ggagcagttc atcgcacagg tcgatctgtg tgtggactgc      420

acaactggct gcctcaaagg gcttgccaac gtgcagtgtt ctgacctgct caagaagtgg      480

ctgccgcaac gctgtgcgac ctttgccagc aagatccagg gccaggtgga caagatcaag      540

ggggccggtg gtgac                                                       555


<210>  10
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rluc1

<400>  10
atggcttcca aggtgtacga ccccgagcaa cgcaaacgca tgatcactgg gcctcagtgg       60

tgggctcgct gcaagcaaat gaacgtgctg gactccttca tcaactacta tgattccgag      120

aagcacgccg agaacgccgt gatttttctg catggtaacg ctgcctccag ctacctgtgg      180

aggcacgtcg tgcctcacat cgagcccgtg gctagatgca tcatccctga tctgatcgga      240

atgggtaagt ccggcaagag cgggaatggc tcatatcgcc tcctggatca ctacaagtac      300

ctcaccgctt ggttcgagct gctgaacctt ccaaagaaaa tcatctttgt gggccacgac      360

tggggggctt gtctggcctt tcactactcc tacgagcacc aagacaagat caaggccatc      420

gtccatgctg agagtgtcgt ggacgtgatc gagtcctggg acgagtggcc tgacatcgag      480

gaggatatcg ccctgatcaa gagcgaagag ggcgagaaaa tggtgcttga gaataacttc      540

ttcgtcgaga ccatgctccc aagcaagatc atgcggaaac tggagcctga ggagttcgct      600

gcctacctgg agccattcaa ggagaagggc gaggttagac ggcctaccct ctcctggcct      660

cgcgagatcc ctctcgttaa gggaggcaag cccgacgtcg tccagattgt ccgcaactac      720

aacgcctacc ttcgggccag cgacgatctg cctaagatgt tcatcgagtc cgaccctggg      780

ttcttttcca acgctattgt cgagggagct aagaagttcc ctaacaccga gttcgtgaag      840

gtgaagggcc tccacttcag ccaggaggac gctccagatg aaatgggtaa gtacatcaag      900

agcttcgtgg agcgcgtgct gaagaacgag cagtaa                                936


<210>  11
<211>  1160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rluc2

<400>  11
atgaaaccgg ctcggattcc gcccgcgtgc gccatcccct cagctagcag gtgtgagcgg       60

ctttctgccc gcagtctcta cacagctcag catcctgacg cctcctcccc ttgcaggggc      120

gtgaagctac ttcagactct gctgtgacga cttggccgcc aggcaccgat cctccccggt      180

gagaaggtcc acgaatctta ctgcagacag atttgctcag cgcgatggct tccaaggtgt      240

acgaccccga gcaacgcaaa cgcatgatca ctgggcctca gtggtgggct cgctgcaagc      300

aaatgaacgt gctggactcc ttcatcaact actatgattc cgagaagcac gccgagaacg      360

ccgtgatttt tctgcatggt aacgctgcct ccagctacct gtggaggcac gtcgtgcctc      420

acatcgagcc cgtggctaga tgcatcatcc ctgatctgat cggaatgggt aagtccggca      480

agagcgggaa tggctcatat cgcctcctgg atcactacaa gtacctcacc gcttggttcg      540

agctgctgaa ccttccaaag aaaatcatct ttgtgggcca cgactggggg gcttgtctgg      600

cctttcacta ctcctacgag caccaagaca agatcaaggc catcgtccat gctgagagtg      660

tcgtggacgt gatcgagtcc tgggacgagt ggcctgacat cgaggaggat atcgccctga      720

tcaagagcga agagggcgag aaaatggtgc ttgagaataa cttcttcgtc gagaccatgc      780

tcccaagcaa gatcatgcgg aaactggagc ctgaggagtt cgctgcctac ctggagccat      840

tcaaggagaa gggcgaggtt agacggccta ccctctcctg gcctcgcgag atccctctcg      900

ttaagggagg caagcccgac gtcgtccaga ttgtccgcaa ctacaacgcc taccttcggg      960

ccagcgacga tctgcctaag atgttcatcg agtccgaccc tgggttcttt tccaacgcta     1020

ttgtcgaggg agctaagaag ttccctaaca ccgagttcgt gaaggtgaag ggcctccact     1080

tcagccagga ggacgctcca gatgaaatgg gtaagtacat caagagcttc gtggagcgcg     1140

tgctgaagaa cgagcagtaa                                                 1160


<210>  12
<211>  1061
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-EgFP

<400>  12
agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc       60

gggatcactc tcggcatgga cgagctgtac aagtaacaaa caaacaaaac aaaaacactc      120

ccctgtgagg aactactgtc ttcacgcaga aagcgtctag ccatggcgtt agtatgagtg      180

tcgtgcagcc tccaggaccc cccctcccgg gagagccata gtggtctgcg gaaccggtga      240

gtacaccgga attgccagga cgaccgggtc ctttcttgga taaacccgct caatgcctgg      300

agatttgggc gtgcccccgc aagactgcta gccgagtagt gttgggtcgc gaaaggcctt      360

gtggtactgc ctgatagggt gcttgcgagt gccccgggag gtctcgtaga ccgtgcacca      420

tgagcacgaa tcctaaaatg gtgagcaagg gcgaggagct gttcaccggg gtggtgccca      480

tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg      540

agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc      600

ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct      660

accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa ggctacgtcc      720

aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt      780

tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc aaggaggacg      840

gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc tatatcatgg      900

ccgacaagca gaagaacggc atcaaggtga acttcaagat ccgccacaac atcgaggacg      960

gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac ggccccgtgc     1020

tgctgcccga caaccactac ctgagcaccc agtccgccct g                         1061


<210>  13
<211>  899
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES-gluc

<400>  13
agcagttcat cgcacaggtc gatctgtgtg tggactgcac aactggctgc ctcaaagggc       60

ttgccaacgt gcagtgttct gacctgctca agaagtggct gccgcaacgc tgtgcgacct      120

ttgccagcaa gatccagggc caggtggaca agatcaaggg ggccggtggt gactaacaaa      180

caaacaaaac aaaaacactc ccctgtgagg aactactgtc ttcacgcaga aagcgtctag      240

ccatggcgtt agtatgagtg tcgtgcagcc tccaggaccc cccctcccgg gagagccata      300

gtggtctgcg gaaccggtga gtacaccgga attgccagga cgaccgggtc ctttcttgga      360

taaacccgct caatgcctgg agatttgggc gtgcccccgc aagactgcta gccgagtagt      420

gttgggtcgc gaaaggcctt gtggtactgc ctgatagggt gcttgcgagt gccccgggag      480

gtctcgtaga ccgtgcacca tgagcacgaa tcctaaaatg ggagtcaaag ttctgtttgc      540

cctgatctgc atcgctgtgg ccgaggccaa gcccaccgag aacaacgaag acttcaacat      600

cgtggccgtg gccagcaact tcgcgaccac ggatctcgat gctgaccgcg ggaagttgcc      660

cggcaagaag ctgccgctgg aggtgctcaa agagatggaa gccaatgccc ggaaagctgg      720

ctgcaccagg ggctgtctga tctgcctgtc ccacatcaag tgcacgccca agatgaagaa      780

gttcatccca ggacgctgcc acacctacga aggcgacaaa gagtccgcac agggcggcat      840

aggcgaggcg atcgtcgaca ttcctgagat tcctgggttc aaggacttgg agcccatgg       899


<210>  14
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  arm1

<400>  14
aataccttac ttaatagtaa caatagaaaa tc                                     32


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  arm2

<400>  15
aagctagatc atattactat taagtaaggt att                                    33


<210>  16
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cRNAzyme (Cte-Rluc)

<400>  16
aataccttac ttaatagtaa caatagaaaa tcctattatc gagcgaacgc cttatgcgat       60

gaaagtcgca cgtagggtgt agaccaagcg aaatcctatg catttaggat agtgaggtat      120

agcaaaatgg cttccaaggt gtacgacccc gagcaacgca aacgcatgat cactgggcct      180

cagtggtggg ctcgctgcaa gcaaatgaac gtgctggact ccttcatcaa ctactatgat      240

tccgagaagc acgccgagaa cgccgtgatt tttctgcatg gtaacgctgc ctccagctac      300

ctgtggaggc acgtcgtgcc tcacatcgag cccgtggcta gatgcatcat ccctgatctg      360

atcggaatgg gtaagtccgg caagagcggg aatggctcat atcgcctcct ggatcactac      420

aagtacctca ccgcttggtt cgagctgctg aaccttccaa agaaaatcat ctttgtgggc      480

cacgactggg gggcttgtct ggcctttcac tactcctacg agcaccaaga caagatcaag      540

gccatcgtcc atgctgagag tgtcgtggac gtgatcgagt cctgggacga gtggcctgac      600

atcgaggagg atatcgccct gatcaagagc gaagagggcg agaaaatggt gcttgagaat      660

aacttcttcg tcgagaccat gctcccaagc aagatcatgc ggaaactgga gcctgaggag      720

ttcgctgcct acctggagcc attcaaggag aagggcgagg ttagacggcc taccctctcc      780

tggcctcgcg agatccctct cgttaaggga ggcaagcccg acgtcgtcca gattgtccgc      840

aactacaacg cctaccttcg ggccagcgac gatctgccta agatgttcat cgagtccgac      900

cctgggttct tttccaacgc tattgtcgag ggagctaaga agttccctaa caccgagttc      960

gtgaaggtga agggcctcca cttcagccag gaggacgctc cagatgaaat gggtaagtac     1020

atcaagagct tcgtggagcg cgtgctgaag aacgagcagt aagccataca ataaaagtgc     1080

gaaacgttat cctataagta agaaagtttt aaaattttct tacgaaaagg atagaactta     1140

aaagttctaa ctgttctact aaagtaataa gtgaaaatct tatttaaagc aaacaaccaa     1200

gtagctttaa gtctaagtcc cctacacaag ttttatacta ctatgcaaaa cttgtgaagc     1260

taggtaaggt cgtaatccgt gaaagtcgga tgcggggctc cttaaaagat tactatggta     1320

aacataagct aatccattaa gatgcgattt atatgtattt tatactgtta aatatttttg     1380

tgcttgtggc ttggtataaa acagttaaga tgaagtactt aactggtttt ggaataattg     1440

gttgttaaac taaaacatta taaatcgtta gtggatacct aaggtaatca aaaataggga     1500

taggtagaat ggaacgtttg atgctgtata tgaagaggtt tagtagaacc taggacacat     1560

atacgggctc agcaggttca tagtagctat gatactcagc cggaagtcaa ttaattttga     1620

aatacttcta tggtaacata ggagaaggat aaaactgagt gagccaagga acctagtcgg     1680

taatagaagc tagatcatat tactattaag taaggtatt                            1719


<210>  17
<211>  989
<212>  RNA
<213>  Bacillus thuringiensis

<400>  17
caaaggcuua ccuaucacua gcgcgacacg uuccuaagug aaaagcuuag gcacugucga       60

acucaacagu ucagcaguga acugucauuc uaagaaguca aaugaaggag uaacgucugg      120

aagggcuucc cuuaauccuc cgacaugcag gaaaguaggc aaguacugaa cugugugaag      180

cucggugaag ucgguugaag guuaccguaa auuaguaucu cuaauacgaa agcuauccag      240

cgguggaugg uguaacugau agaccggagg ucuauaaaac acucaagguu aggaugcgcg      300

augaacuaga ggcgaucgcu aguaagcgca gacgaauccc ugaugguacg ggucuauauc      360

gggagggaau cgaaagguuc ucugacacaa auaagugucg cuacuguggg ugaguaaaac      420

ucuccuuuau gaaagcccau auaucguuac aggcguuauu aagguagcag gcucauaggg      480

gaaaccuaaa aguguaugua cagauaagaa ugacggaacg ugguaagcug ccgacaugga      540

gggcuuguuc ucuuugaagu guugccaagg aaagucacaa ugagauuagu ugucgauaua      600

acuugguuua acggcaguga aagugguggc acaguaccga ugaaacgugu aaugaacgug      660

gagggauagc cacuagucga uugaagauug aagguuacua uugguuaaca ugguuucgag      720

uaagacuaag agauguaaug cuccaaagua auaaggaggu uacagcccau guuaaagaaa      780

accaagcuaa gacauaacga auauuaugau acacaaaaaa aguguaugac aauuuauacu      840

cgaacagucu uaacgguaac aauuucuuuc aauuggaaac gauggaacgc cguaugcccg      900

gaaacgggcg cguacggugu ggaguggggg aaaagcugga gauaaucuca aaggcuuacc      960

uaucacuauc gcgacacguu ccuaaguga                                        989


<210>  18
<211>  1028
<212>  RNA
<213>  Clostridium tetani

<400>  18
gccauacaau aaaagugcga aacguuaucc uauaaguaag aaaguuuuaa aauuuucuua       60

cgaaaaggau agaacuuaaa aguucuaacu guucuacuaa aguaauaagu gaaaaucuua      120

uuuaaagcaa acaaccaagu agcuuuaagu cuaagucccc uacacaaguu uuauacuacu      180

augcaaaacu ugugaagcua gguaaggucg uaauccguga aagucggaug cggggcuccu      240

uaaaagauua cuaugguaaa cauaagcuaa uccauuaaga ugcgauuuau auguauuuua      300

uacuguuaaa uauuuuugug cuuguggcuu gguauaaaac aguuaagaug aaguacuuaa      360

cugguuuugg aauaauuggu uguuaaacua aaacauuaua aaucguuagu ggauaccuaa      420

gguaaucaaa aauagggaua gguagaaugg aacguuugau gcuguauaug aagagguuua      480

guagaaccua ggacacauau acgggcucag cagguucaua guagcuauga uacucagccg      540

gaagucaauu aauuuugaaa uacuucuaug guaacauagg agaaggauaa aacugaguga      600

gccaaggaac cuagucggua auagaaaagu ggaaguuaaa acaaauauaa gauuuuagaa      660

uuaauuuaau uaaugaacgg aauuaauuua augauauuua aaguuagacg guuauaaauu      720

aaacauuuca aaauuaaacc auauccaaau ucauaaauau agcuagauca uaucacuagu      780

uuaaaaauaa auaaaucauu ucaaauuacu auuaaguaag guauuaauac cuuacuuaau      840

aguaaucuca uuacauaaga gaauuacuag auuagcagac agauucauaa aaacuauauc      900

aacuaggaca auagaaaaua uauuuauaca cuuccuauua ucgagcgaac gccuuaugcg      960

augaaagucg cacguagggu guagaccaag cgaaauccua ugcauuuagg auagugaggu     1020

auagcaaa                                                              1028


<210>  19
<211>  1028
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Group II intron Cte_mut

<400>  19
gcaagacaau aaaaguuuga cacgugaucc uauaaguaag aaaguuuuaa aauuuucuua       60

cgaaaaggau agaacuuaaa aguucuaacu guucuacuaa aguaauaagu gaaaaucuua      120

uuuaaagcaa acaaccaagu agcuuuaagu cuaagucccc uacacaaguu uuauacuacu      180

augcaaaacu ugugaagcua gguaaggucg uaauccguga aagucggaug cggggcuccu      240

uaaaagauua cuaugguaaa cauaagcuaa uccauuaaga ugcgauuuau auguauuuua      300

uacuguuaaa uauuuuugug cuuguggcuu gguauaaaac aguuaagaug aaguacuuaa      360

cugguuuugg aauaauuggu uguuaaacua aaacauuaua aaucguuagu ggauaccuaa      420

gguaaucaaa aauagggaua gguagaaugg aacguuugau gcuguauaug aagagguuua      480

guagaaccua ggacacauau acgggcucag cagguucaua guagcuauga uacucagccg      540

gaagucaauu aauuuugaaa uacuucuaug guaacauagg agaaggauaa aacugaguga      600

gccaaggaac cuagucggua auagaaaagu ggaaguuaaa acaaauauaa gauuuuagaa      660

uuaauuuaau uaaugaacgg aauuaauuua augauauuua aaguuagacg guuauaaauu      720

aaacauuuca aaauuaaacc auauccaaau ucauaaauau agcuagauca uaucacuagu      780

uuaaaaauaa auaaaucauu ucaaauuacu auuaaguaag guauuaauac cuuacuuaau      840

aguaaucuca uuacauaaga gaauuacuag auuagcagac agauucauaa aaacuauauc      900

aacuaggaca auagaaaaua uauuuauaca cuuccuauua ucgagcgaac gccuuaugcg      960

augaaagucg cacguagggu guagaccaag cgaaauccua ugcauuuagg auagugaggu     1020

auagcaaa                                                              1028


<210>  20
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence 1

<400>  20
gcaauagccg aaaaacaaaa aacaaaaaaa acaaaaaaaa aaccaaaaaa acaaaacaca       60


<210>  21
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence2

<400>  21
aaauuauaau aauuauaaua                                                   20


<210>  22
<211>  224
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Spacer sequence 3

<400>  22
augaaaccgg cucggauucc gcccgcgugc gccauccccu cagcuagcag gugugagcgg       60

cuuucugccc gcagucucua cacagcucag cauccugacg ccuccucccc uugcaggggc      120

gugaagcuac uucagacucu gcugugacga cuuggccgcc aggcaccgau ccuccccggu      180

gagaaggucc acgaaucuua cugcagacag auuugcucag cgcg                       224


<210>  23
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Probe1

<400>  23
cuuucacuac uccuacgagc acca                                              24


<210>  24
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Probe2

<400>  24
gaccaugcuc ccaagcaaga ucaug                                             25


<210>  25
<211>  555
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Gluc

<400>  25
augggaguca aaguucuguu ugcccugauc ugcaucgcug uggccgaggc caagcccacc       60

gagaacaacg aagacuucaa caucguggcc guggccagca acuucgcgac cacggaucuc      120

gaugcugacc gcgggaaguu gcccggcaag aagcugccgc uggaggugcu caaagagaug      180

gaagccaaug cccggaaagc uggcugcacc aggggcuguc ugaucugccu gucccacauc      240

aagugcacgc ccaagaugaa gaaguucauc ccaggacgcu gccacaccua cgaaggcgac      300

aaagaguccg cacagggcgg cauaggcgag gcgaucgucg acauuccuga gauuccuggg      360

uucaaggacu uggagcccau ggagcaguuc aucgcacagg ucgaucugug uguggacugc      420

acaacuggcu gccucaaagg gcuugccaac gugcaguguu cugaccugcu caagaagugg      480

cugccgcaac gcugugcgac cuuugccagc aagauccagg gccaggugga caagaucaag      540

ggggccggug gugac                                                       555


<210>  26
<211>  936
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Rluc1

<400>  26
auggcuucca agguguacga ccccgagcaa cgcaaacgca ugaucacugg gccucagugg       60

ugggcucgcu gcaagcaaau gaacgugcug gacuccuuca ucaacuacua ugauuccgag      120

aagcacgccg agaacgccgu gauuuuucug caugguaacg cugccuccag cuaccugugg      180

aggcacgucg ugccucacau cgagcccgug gcuagaugca ucaucccuga ucugaucgga      240

auggguaagu ccggcaagag cgggaauggc ucauaucgcc uccuggauca cuacaaguac      300

cucaccgcuu gguucgagcu gcugaaccuu ccaaagaaaa ucaucuuugu gggccacgac      360

uggggggcuu gucuggccuu ucacuacucc uacgagcacc aagacaagau caaggccauc      420

guccaugcug agagugucgu ggacgugauc gaguccuggg acgaguggcc ugacaucgag      480

gaggauaucg cccugaucaa gagcgaagag ggcgagaaaa uggugcuuga gaauaacuuc      540

uucgucgaga ccaugcuccc aagcaagauc augcggaaac uggagccuga ggaguucgcu      600

gccuaccugg agccauucaa ggagaagggc gagguuagac ggccuacccu cuccuggccu      660

cgcgagaucc cucucguuaa gggaggcaag cccgacgucg uccagauugu ccgcaacuac      720

aacgccuacc uucgggccag cgacgaucug ccuaagaugu ucaucgaguc cgacccuggg      780

uucuuuucca acgcuauugu cgagggagcu aagaaguucc cuaacaccga guucgugaag      840

gugaagggcc uccacuucag ccaggaggac gcuccagaug aaauggguaa guacaucaag      900

agcuucgugg agcgcgugcu gaagaacgag caguaa                                936


<210>  27
<211>  1160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Rluc2

<400>  27
augaaaccgg cucggauucc gcccgcgugc gccauccccu cagcuagcag gugugagcgg       60

cuuucugccc gcagucucua cacagcucag cauccugacg ccuccucccc uugcaggggc      120

gugaagcuac uucagacucu gcugugacga cuuggccgcc aggcaccgau ccuccccggu      180

gagaaggucc acgaaucuua cugcagacag auuugcucag cgcgauggcu uccaaggugu      240

acgaccccga gcaacgcaaa cgcaugauca cugggccuca guggugggcu cgcugcaagc      300

aaaugaacgu gcuggacucc uucaucaacu acuaugauuc cgagaagcac gccgagaacg      360

ccgugauuuu ucugcauggu aacgcugccu ccagcuaccu guggaggcac gucgugccuc      420

acaucgagcc cguggcuaga ugcaucaucc cugaucugau cggaaugggu aaguccggca      480

agagcgggaa uggcucauau cgccuccugg aucacuacaa guaccucacc gcuugguucg      540

agcugcugaa ccuuccaaag aaaaucaucu uugugggcca cgacuggggg gcuugucugg      600

ccuuucacua cuccuacgag caccaagaca agaucaaggc caucguccau gcugagagug      660

ucguggacgu gaucgagucc ugggacgagu ggccugacau cgaggaggau aucgcccuga      720

ucaagagcga agagggcgag aaaauggugc uugagaauaa cuucuucguc gagaccaugc      780

ucccaagcaa gaucaugcgg aaacuggagc cugaggaguu cgcugccuac cuggagccau      840

ucaaggagaa gggcgagguu agacggccua cccucuccug gccucgcgag aucccucucg      900

uuaagggagg caagcccgac gucguccaga uuguccgcaa cuacaacgcc uaccuucggg      960

ccagcgacga ucugccuaag auguucaucg aguccgaccc uggguucuuu uccaacgcua     1020

uugucgaggg agcuaagaag uucccuaaca ccgaguucgu gaaggugaag ggccuccacu     1080

ucagccagga ggacgcucca gaugaaaugg guaaguacau caagagcuuc guggagcgcg     1140

ugcugaagaa cgagcaguaa                                                 1160


<210>  28
<211>  1061
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRES-EgFP

<400>  28
agcaaagacc ccaacgagaa gcgcgaucac augguccugc uggaguucgu gaccgccgcc       60

gggaucacuc ucggcaugga cgagcuguac aaguaacaaa caaacaaaac aaaaacacuc      120

cccugugagg aacuacuguc uucacgcaga aagcgucuag ccauggcguu aguaugagug      180

ucgugcagcc uccaggaccc ccccucccgg gagagccaua guggucugcg gaaccgguga      240

guacaccgga auugccagga cgaccggguc cuuucuugga uaaacccgcu caaugccugg      300

agauuugggc gugcccccgc aagacugcua gccgaguagu guugggucgc gaaaggccuu      360

gugguacugc cugauagggu gcuugcgagu gccccgggag gucucguaga ccgugcacca      420

ugagcacgaa uccuaaaaug gugagcaagg gcgaggagcu guucaccggg guggugccca      480

uccuggucga gcuggacggc gacguaaacg gccacaaguu cagcgugucc ggcgagggcg      540

agggcgaugc caccuacggc aagcugaccc ugaaguucau cugcaccacc ggcaagcugc      600

ccgugcccug gcccacccuc gugaccaccc ugaccuacgg cgugcagugc uucagccgcu      660

accccgacca caugaagcag cacgacuucu ucaaguccgc caugcccgaa ggcuacgucc      720

aggagcgcac caucuucuuc aaggacgacg gcaacuacaa gacccgcgcc gaggugaagu      780

ucgagggcga cacccuggug aaccgcaucg agcugaaggg caucgacuuc aaggaggacg      840

gcaacauccu ggggcacaag cuggaguaca acuacaacag ccacaacguc uauaucaugg      900

ccgacaagca gaagaacggc aucaagguga acuucaagau ccgccacaac aucgaggacg      960

gcagcgugca gcucgccgac cacuaccagc agaacacccc caucggcgac ggccccgugc     1020

ugcugcccga caaccacuac cugagcaccc aguccgcccu g                         1061


<210>  29
<211>  899
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRES-gluc

<400>  29
agcaguucau cgcacagguc gaucugugug uggacugcac aacuggcugc cucaaagggc       60

uugccaacgu gcaguguucu gaccugcuca agaaguggcu gccgcaacgc ugugcgaccu      120

uugccagcaa gauccagggc cagguggaca agaucaaggg ggccgguggu gacuaacaaa      180

caaacaaaac aaaaacacuc cccugugagg aacuacuguc uucacgcaga aagcgucuag      240

ccauggcguu aguaugagug ucgugcagcc uccaggaccc ccccucccgg gagagccaua      300

guggucugcg gaaccgguga guacaccgga auugccagga cgaccggguc cuuucuugga      360

uaaacccgcu caaugccugg agauuugggc gugcccccgc aagacugcua gccgaguagu      420

guugggucgc gaaaggccuu gugguacugc cugauagggu gcuugcgagu gccccgggag      480

gucucguaga ccgugcacca ugagcacgaa uccuaaaaug ggagucaaag uucuguuugc      540

ccugaucugc aucgcugugg ccgaggccaa gcccaccgag aacaacgaag acuucaacau      600

cguggccgug gccagcaacu ucgcgaccac ggaucucgau gcugaccgcg ggaaguugcc      660

cggcaagaag cugccgcugg aggugcucaa agagauggaa gccaaugccc ggaaagcugg      720

cugcaccagg ggcugucuga ucugccuguc ccacaucaag ugcacgccca agaugaagaa      780

guucauccca ggacgcugcc acaccuacga aggcgacaaa gaguccgcac agggcggcau      840

aggcgaggcg aucgucgaca uuccugagau uccuggguuc aaggacuugg agcccaugg       899


<210>  30
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  arm1

<400>  30
aauaccuuac uuaauaguaa caauagaaaa uc                                     32


<210>  31
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  arm2

<400>  31
aagcuagauc auauuacuau uaaguaaggu auu                                    33


<210>  32
<211>  1719
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  cRNAzyme (Cte-Rluc)

<400>  32
aauaccuuac uuaauaguaa caauagaaaa uccuauuauc gagcgaacgc cuuaugcgau       60

gaaagucgca cguagggugu agaccaagcg aaauccuaug cauuuaggau agugagguau      120

agcaaaaugg cuuccaaggu guacgacccc gagcaacgca aacgcaugau cacugggccu      180

cagugguggg cucgcugcaa gcaaaugaac gugcuggacu ccuucaucaa cuacuaugau      240

uccgagaagc acgccgagaa cgccgugauu uuucugcaug guaacgcugc cuccagcuac      300

cuguggaggc acgucgugcc ucacaucgag cccguggcua gaugcaucau cccugaucug      360

aucggaaugg guaaguccgg caagagcggg aauggcucau aucgccuccu ggaucacuac      420

aaguaccuca ccgcuugguu cgagcugcug aaccuuccaa agaaaaucau cuuugugggc      480

cacgacuggg gggcuugucu ggccuuucac uacuccuacg agcaccaaga caagaucaag      540

gccaucgucc augcugagag ugucguggac gugaucgagu ccugggacga guggccugac      600

aucgaggagg auaucgcccu gaucaagagc gaagagggcg agaaaauggu gcuugagaau      660

aacuucuucg ucgagaccau gcucccaagc aagaucaugc ggaaacugga gccugaggag      720

uucgcugccu accuggagcc auucaaggag aagggcgagg uuagacggcc uacccucucc      780

uggccucgcg agaucccucu cguuaaggga ggcaagcccg acgucgucca gauuguccgc      840

aacuacaacg ccuaccuucg ggccagcgac gaucugccua agauguucau cgaguccgac      900

ccuggguucu uuuccaacgc uauugucgag ggagcuaaga aguucccuaa caccgaguuc      960

gugaagguga agggccucca cuucagccag gaggacgcuc cagaugaaau ggguaaguac     1020

aucaagagcu ucguggagcg cgugcugaag aacgagcagu aagccauaca auaaaagugc     1080

gaaacguuau ccuauaagua agaaaguuuu aaaauuuucu uacgaaaagg auagaacuua     1140

aaaguucuaa cuguucuacu aaaguaauaa gugaaaaucu uauuuaaagc aaacaaccaa     1200

guagcuuuaa gucuaagucc ccuacacaag uuuuauacua cuaugcaaaa cuugugaagc     1260

uagguaaggu cguaauccgu gaaagucgga ugcggggcuc cuuaaaagau uacuauggua     1320

aacauaagcu aauccauuaa gaugcgauuu auauguauuu uauacuguua aauauuuuug     1380

ugcuuguggc uugguauaaa acaguuaaga ugaaguacuu aacugguuuu ggaauaauug     1440

guuguuaaac uaaaacauua uaaaucguua guggauaccu aagguaauca aaaauaggga     1500

uagguagaau ggaacguuug augcuguaua ugaagagguu uaguagaacc uaggacacau     1560

auacgggcuc agcagguuca uaguagcuau gauacucagc cggaagucaa uuaauuuuga     1620

aauacuucua ugguaacaua ggagaaggau aaaacugagu gagccaagga accuagucgg     1680

uaauagaagc uagaucauau uacuauuaag uaagguauu                            1719


<210>  33
<211>  426
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Group II Intron

<400>  33
cucucuaaau agcaauauuu accuuuggag ggaaaaguua ucaggcaugc accugguagc       60

uagucuuuaa accaauagau ugcaucgguu uaaaaggcaa gaccgucaaa uugcgggaaa      120

ggggucaaca gccguucagu accaagucuc aggggaaacu uugagauggc cuugcaaagg      180

guaugguaau aagcugacgg acaugguccu aaccacgcag ccaaguccua agucaacaga      240

ucuucuguug auauggaugc aguucacaga cuaaaugucg gucggggaag auguauucuu      300

cucauaagau auagucggac cucuccuuaa ugggagcuag cggaugaagu gaugcaacac      360

uggagccgcu gggaacuaau uuguaugcga aaguauauug auuaguuuug gaguacucgu      420

aaggua                                                                 426


<210>  34
<211>  787
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Group II Intron

<400>  34
ugcaugugau gcaggucgug gugcgaaucg uuccuaagug aaaagcuuag gcaucuuaga       60

caagggaagg ccccauuaag auagaacuaa ugauucgaga gacagaauga uagaguaacg      120

ucuugaaaug uuuccccuaa gucuccgaca ugcauugaaa gguaggaugu uuaaaugugu      180

gaagcucggu gaagacggcu gacagauacc guagugaaaa auguguuuua accgaaaguc      240

cuuuuaguaa gaggauguau cccauaggcc ggggguccgu aaaguaucua uggugagaau      300

guuauaugaa auaacugacg aacuuucgaa uuaacgaguc uauaaccaua caaucagaaa      360

ugauaguaaa ccauauuuug uguugugugu gagguuaagu aaauucgcgg cuaugaacaa      420

ccuuacagua uuauagguac ugucuagcac gcaggcucau agaaggcacc uaaggguacc      480

auauagugga uagaaucauu ggaacgauga aagcucagga cgcagagaac cuacauucug      540

ugaagcggug guaaggaaaa ggaggaaucc uauaacuuau cuuuauuuga gugauagcga      600

ugucauagua gcguggaauu uauggaaaca uaaaggagcg aagggcauua gucaauauug      660

ugaggaaaaa gcaauauuga uggcaagccg uaugaaggga aacuuucaug uacgguuuag      720

ugugggggaa aaagcagaga uuauaucaaa guuuuaccua ucacaauaag gagagaauau      780

uuuuaau                                                                787


<210>  35
<211>  989
<212>  RNA
<213>  artificial sequence

<220>
<223>  Group II Intron

<400>  35
caaaggcuua ccuaucacua gcgcgacacg uuccuaagug aaaagcuuag gcacugucga       60

acucaacagu ucagcaguga acugucauuc uaagaaguca aaugaaggag uaacgucugg      120

aagggcuucc cuuaauccuc cgacaugcag gaaaguaggc aaguacugaa cugugugaag      180

cucggugaag ucgguugaag guuaccguaa auuaguaucu cuaauacgaa agcuauccag      240

cgguggaugg uguaacugau agaccggagg ucuauaaaac acucaagguu aggaugcgcg      300

augaacuaga ggcgaucgcu aguaagcgca gacgaauccc ugaugguacg ggucuauauc      360

gggagggaau cgaaagguuc ucugacacaa auaagugucg cuacuguggg ugaguaaaac      420

ucuccuuuau gaaagcccau auaucguuac aggcguuauu aagguagcag gcucauaggg      480

gaaaccuaaa aguguaugua cagauaagaa ugacggaacg ugguaagcug ccgacaugga      540

gggcuuguuc ucuuugaagu guugccaagg aaagucacaa ugagauuagu ugucgauaua      600

acuugguuua acggcaguga aagugguggc acaguaccga ugaaacgugu aaugaacgug      660

gagggauagc cacuagucga uugaagauug aagguuacua uugguuaaca ugguuucgag      720

uaagacuaag agauguaaug cuccaaagua auaaggaggu uacagcccau guuaaagaaa      780

accaagcuaa gacauaacga auauuaugau acacaaaaaa aguguaugac aauuuauacu      840

cgaacagucu uaacgguaac aauuucuuuc aauuggaaac gauggaacgc cguaugcccg      900

gaaacgggcg cguacggugu ggaguggggg aaaagcugga gauaaucuca aaggcuuacc      960

uaucacuauc gcgacacguu ccuaaguga                                        989


<210>  36
<211>  867
<212>  RNA
<213>  artificial sequence

<220>
<223>  Group II Intron

<400>  36
uuauaacaaa guaguuauuu gugcgacacg uuucuuuaua agugugcaaa cacgaaguag       60

gaggguuauc aauuugauga caacaacgga uugacugcaa guaggaauga aagccgucag      120

guugagcuga aacuacuuau cugauacucc uauaugcaag gcgugauagu agucacaaau      180

uguaugaagc uaggugaagu cggcugaaca aaaccuaagu gagaaaucau augguaaugg      240

auaggucggg augcuacaaa acaucuaugg ugagaauguc cuaacggacu ggcgaaugua      300

cagguuuaaa ggauuaauuc auuagaaaug uguauauugu caacgacgac gcuaucuacc      360

gaaaaguaag aguaaauaau augaaauucg gaagaucuaa cgaugaggau guaaagauaa      420

caggcuuaca gcaagcaccu aaagauauau guauagcuaa gucauucaga acgugguaag      480

caagagacug ucacaaaugc cuacuaacag acaaggugca uauaagguuc uaacgaacca      540

aaauugcuuu auucuuguga agguggggac acaguaccga cgaagcaugu aacaaaugug      600

gagggauagu cccuagucuu guucguugaa aacuaaauca acuggauaua acucacagga      660

ucgaguaaga ugaugugacu uuucguaaga aaagggaaug aauacguugg ugaguacaac      720

augguuugua aucuaguugu uuuaguauaa aaggauaaga uggggcgcug uaugcgauga      780

aagucgcacg uacaguguca agcgggggaa aagauggaga uaacuuuaaa gucuuaccua      840

ucgcaacgga uaaaaagaau cccugcu                                          867


<210>  37
<211>  1046
<212>  RNA
<213>  artificial sequence

<220>
<223>  Group II Intron

<400>  37
gaauauacua uagccauaca auaaaagugc gaaacguuau ccuauaagua agaaaguuuu       60

aaaauuuucu uacgaaaagg auagaacuua aaaguucuaa cuguucuacu aaaguaauaa      120

gugaaaaucu uauuuaaagc aaacaaccaa guagcuuuaa gucuaagucc ccuacacaag      180

uuuuauacua cuaugcaaaa cuugugaagc uagguaaggu cguaauccgu gaaagucgga      240

ugcggggcuc cuuaaaagau uacuauggua aacauaagcu aauccauuaa gaugcgauuu      300

auauguauuu uauacuguua aauauuuuug ugcuuguggc uugguauaaa acaguuaaga      360

ugaaguacuu aacugguuuu ggaauaauug guuguuaaac uaaaacauua uaaaucguua      420

guggauaccu aagguaauca aaaauaggga uagguagaau ggaacguuug augcuguaua      480

ugaagagguu uaguagaacc uaggacacau auacgggcuc agcagguuca uaguagcuau      540

gauacucagc cggaagucaa uuaauuuuga aauacuucua ugguaacaua ggagaaggau      600

aaaacugagu gagccaagga accuagucgg uaauagaaaa guggaaguua aaacaaauau      660

aagauuuuag aauuaauuua auuaaugaac ggaauuaauu uaaugauauu uaaaguuaga      720

cgguuauaaa uuaaacauuu caaaauuaaa ccauauccaa auucauaaau auagcuagau      780

cauaucacua guuuaaaaau aaauaaauca uuucaaauua cuauuaagua agguauuaau      840

accuuacuua auaguaaucu cauuacauaa gagaauuacu agauuagcag acagauucau      900

aaaaacuaua ucaacuagga caauagaaaa uauauuuaua cacuuccuau uaucgagcga      960

acgccuuaug cgaugaaagu cgcacguagg guguagacca agcgaaaucc uaugcauuua     1020

ggauagugag guauagcaaa ggagaa                                          1046


<210>  38
<211>  626
<212>  RNA
<213>  artificial sequence

<220>
<223>  Group II Intron

<400>  38
acucuaggua gacgagagug cgacuaguaa agugcuuaau aacaaugugg ugaaagccca       60

ccagauaacc cauuaucuga gcucagacgg uaugcauuag aaguaauucu uuuguguaaa      120

gcccguuuaa uuugguaaac agaccaacca accuauauau aaggauggug agcuauauua      180

cuauggauaa aauuuuuaug aauucacguu cgaagcguau uagagugagu uuuauuuaga      240

aggaaaaaag uaaauaaaau ucuaauuaau uguauaaaca auuuuucguu uguuuauuaa      300

ugggucuuau auuaauguac guauagugaa auccuaaggu aguaaauaag guguuauuaa      360

guaaacuagg uaagcccaau aauaucuuca uaugauagua ugaagaaguu caaguguaaa      420

uuugaauaua uauuaguggg uaaaggauau uuuaaaaagc gaaugucuca uauuaauagu      480

gagaauaggu uuaugacuaa uucgaaagaa ugcugacuua aaauuaauau uaauauuucg      540

auauuaauau uugagccgua ugcgaugaaa gucgcacgua cgguucuuag agggggaaag      600

uccaagaggg ccuaccuauc ucaaca                                           626


<210>  39
<211>  639
<212>  RNA
<213>  artificial sequence

<220>
<223>  Group II Intron

<400>  39
cucuagauag acgagagugc gacuagauaa guacuuaaua gcaauguggu gaaaguccac       60

cugauaaccc auagucugag cucagacggu augcauuaga aguaauucuu uuguguaaag      120

cccguuuaau cuggucuaaa ggaccuucca cccuaaauau auagggggag agcuauaaua      180

cuaaggauaa aauuuuuuug aauucauguu uaaagcguau uagaggaaau uuauuucuau      240

gaaaaagaag aaauaaauuu uuaauuaacu guauaaacaa guuuucguuu guuuauuagu      300

gggucuuaug uuaauguacg uauaguggaa uccuaaggua uuaauuaagg uguuauuaag      360

uaaacuaggu aagcccaaua gugucuucau auuauaauau gaagaaguuc aauugugaaa      420

uugaauaugc auuagugggu aaaggauauu uuaaaaagcg aaugucucau auuaauagug      480

agaauagguc uaugacuaau ucgaaagaau gcugacuuaa aauugguauu aauauaugcg      540

uuucgaugua uauauuaaua uuugagccgu augcgaugaa agucgcacgu acgguucuua      600

gagggggaaa ucuuaguaau aagacgaccu aucucgaca                             639


<210>  40
<211>  573
<212>  RNA
<213>  artificial sequence

<220>
<223>  Group II Intron

<400>  40
ggguagcaau aaggaugugc gacuuguuaa guuuuaacaa aaauuguaua acguuuauua       60

augauuauac auuguauuuc aucuuacaau agccuaauua gauaugcauu uaggguaacu      120

uuuuuguaua aagcucuaau uauaagugua aauacacuuu uaggcuucuu cuaugguuag      180

agaaaucgaa ccaauguaau uaaaacuuug auguauuagg cauuuaacgu guccuugguu      240

aaaugaagau gaacauaagu auacaaagua aaauuggaac cuaaggaaga auuguuuuug      300

uuaagaaaca agguaauacc uauaacuggc uaauauaaau uugcaagguu uauuguaaaa      360

uaaacuauag guuagaggua aaaggauaau guaaaaagcg aaugcaauuc uguaauggaa      420

uugauagggu auauaccuaa cuugaaagag ugcugacuua cauauagaug uuauuuacgu      480

uucgacguaa auaauguuug agccguaugc uaugaaagua gcacguacgg uucuaagagg      540

gggaaagucc gagaggaccu accuaucuca acu                                   573


<210>  41
<211>  659
<212>  RNA
<213>  artificial sequence

<220>
<223>  Group II Intron

<400>  41
acucuaggua gacgagagug cgacuaguaa aguguuuaau aauaaugugg ugaaaaccca       60

ccagauaacc cauuaucuga gcucauacgg ugugcauuaa aaguaauuuu uuuguauaaa      120

gcccguuuaa ucagguaaau aauccuucca uccuaauuau aucuauagau auaaaaggau      180

ggugagcuau auuacuaugg auaagauuuu uuugaauuca cguuugaagc guauuagagu      240

aaguuuuauu uaaaaggaaa aaaaaaaauu aaauaaaauu aaauuaauug uauaaauaag      300

uuuucguuua uuuauuaaug ggucuuauau uaauguacgu auagugaaau ccuaauguag      360

uaauuaaggu guuauuaaau aaacuaggua agcccaauaa ugucuucaua auaugaagaa      420

guucaagugu aaauuugaau auacauuagu ggguaaagga uauuuuaaaa agcgaauguc      480

ucauauuaau agugagaaua ggucuaugac uaauucgaaa gaaugcugac uuaaaauuaa      540

uauuaauauu aauauauaua uauuaauauu ugagccguau gcgaugaaaa ucgcacguac      600

gguucuuaga gggggaaagc ucgagagggc cuaccuaucu ccacagaccc uaugcagcu       659


<210>  42
<211>  261
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' intron fragment

<400>  42
cuuugagaug gccuugcaaa ggguauggua auaagcugac ggacaugguc cuaaccacgc       60

agccaagucc uaagucaaca gaucuucugu ugauauggau gcaguucaca gacuaaaugu      120

cggucgggga agauguauuc uucucauaag auauagucgg accucuccuu aaugggagcu      180

agcggaugaa gugaugcaac acuggagccg cugggaacua auuuguaugc gaaaguauau      240

ugauuaguuu uggaguacuc g                                                261


<210>  43
<211>  97
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  43
gcaauauuga uggcaagccg uaugaaggga aacuuucaug uacgguuuag ugugggggaa       60

aaagcagaga uuauaucaaa guuuuaccua ucacaau                                97


<210>  44
<211>  98
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  44
auuggaaacg auggaacgcc guaugcccgg aaacgggcgc guacggugug gaguggggga       60

aaagcuggag auaaucucaa aggcuuaccu aucacuau                               98


<210>  45
<211>  95
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  45
ggauaagaug gggcgcugua ugcgaugaaa gucgcacgua cagugucaag cgggggaaaa       60

gauggagaua acuuuaaagu cuuaccuauc gcaac                                  95


<210>  46
<211>  88
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  46
cuauuaucga gcgaacgccu uaugcgauga aagucgcacg uaggguguag accaagcgaa       60

auccuaugca uuuaggauag ugagguau                                          88


<210>  47
<211>  85
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  47
auauuaauau uugagccgua ugcgaugaaa gucgcacgua cgguucuuag agggggaaag       60

uccaagaggg ccuaccuauc ucaac                                             85


<210>  48
<211>  93
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  48
auguauauau uaauauuuga gccguaugcg augaaagucg cacguacggu ucuuagaggg       60

ggaaaucuua guaauaagac gaccuaucuc gac                                    93


<210>  49
<211>  88
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  49
acguaaauaa uguuugagcc guaugcuaug aaaguagcac guacgguucu aagaggggga       60

aaguccgaga ggaccuaccu aucucaac                                          88


<210>  50
<211>  85
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  50
auauuaauau uugagccgua ugcgaugaaa aucgcacgua cgguucuuag agggggaaag       60

cucgagaggg ccuaccuauc uccac                                             85


<210>  51
<211>  408
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  51
gaauaauugg uuguuaaacu aaaacauuau aaaucguuag uggauaccua agguaaucaa       60

aaauagggau agguagaaug gaacguuuga ugcuguauau gaagagguuu aguagaaccu      120

aggacacaua uacgggcuca gcagguucau aguagcuaug auacucagcc ggaagucaau      180

uaauuuugaa auacuucuau gguaacauag gagaaggaua aaacugagug agccaaggaa      240

ccuagucggu aauagaagcu agaucauauu acuauuaagu aagguauuaa uaccuuacuu      300

aauaguaaca auagaaaauc cuauuaucga gcgaacgccu uaugcgauga aagucgcacg      360

uaggguguag accaagcgaa auccuaugca uuuaggauag ugagguau                   408


<210>  52
<211>  217
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' intron fragment

<400>  52
uacuucuaug guaacauagg agaaggauaa aacugaguga gccaaggaac cuagucggua       60

auagaagcua gaucauauua cuauuaagua agguauuaau accuuacuua auaguaacaa      120

uagaaaaucc uauuaucgag cgaacgccuu augcgaugaa agucgcacgu aggguguaga      180

ccaagcgaaa uccuaugcau uuaggauagu gagguau                               217


<210>  53
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  E2

<400>  53
uaaggua                                                                  7


<210>  54
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  54
aaggag                                                                   6


<210>  55
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  55
aaguga                                                                   6


<210>  56
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  56
ccugcu                                                                   6


<210>  57
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  57
agcagu                                                                   6


<210>  58
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  58
agcaaa                                                                   6


<210>  59
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  59
agagaa                                                                   6


<210>  60
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  60
agcaaa                                                                   6


<210>  61
<211>  1
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  61
a                                                                        1


<210>  62
<211>  1
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  62
u                                                                        1


<210>  63
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E2

<400>  63
agaccc                                                                   6


<210>  64
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  64
cucucu                                                                   6


<210>  65
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  65
gucgug                                                                   6


<210>  66
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  E1

<400>  66
caaagg                                                                   6


<210>  67
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  67
uuauuu                                                                   6


<210>  68
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  68
ccaugg                                                                   6


<210>  69
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  69
gcccug                                                                   6


<210>  70
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  70
cguuga                                                                   6


<210>  71
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  71
gccaua                                                                   6


<210>  72
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  72
acgaga                                                                   6


<210>  73
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  73
aaggau                                                                   6


<210>  74
<211>  8
<212>  RNA
<213>  artificial sequence

<220>
<223>  E1

<400>  74
agacgaga                                                                 8


<210>  75
<211>  148
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  75
aaauagcaau auuuaccuuu ggagggaaaa guuaucaggc augcaccugg uagcuagucu       60

uuaaaccaau agauugcauc gguuuaaaag gcaagaccgu caaauugcgg gaaagggguc      120

aacagccguu caguaccaag ucucaggg                                         148


<210>  76
<211>  641
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  76
gugcgaaucg uuccuaagug aaaagcuuag gcaucuuaga caagggaagg ccccauuaag       60

auagaacuaa ugauucgaga gacagaauga uagaguaacg ucuugaaaug uuuccccuaa      120

gucuccgaca ugcauugaaa gguaggaugu uuaaaugugu gaagcucggu gaagacggcu      180

gacagauacc guagugaaaa auguguuuua accgaaaguc cuuuuaguaa gaggauguau      240

cccauaggcc ggggguccgu aaaguaucua uggugagaau guuauaugaa auaacugacg      300

aacuuucgaa uuaacgaguc uauaaccaua caaucagaaa ugauaguaaa ccauauuuug      360

uguugugugu gagguuaagu aaauucgcgg cuaugaacaa ccuuacagua uuauagguac      420

ugucuagcac gcaggcucau agaaggcacc uaaggguacc auauagugga uagaaucauu      480

ggaacgauga aagcucagga cgcagagaac cuacauucug ugaagcggug guaaggaaaa      540

ggaggaaucc uauaacuuau cuuuauuuga gugauagcga ugucauagua gcguggaauu      600

uauggaaaca uaaaggagcg aagggcauua gucaauauug u                          641


<210>  77
<211>  666
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  77
gcgcgacacg uuccuaagug aaaagcuuag gcacugucga acucaacagu ucagcaguga       60

acugucauuc uaagaaguca aaugaaggag uaacgucugg aagggcuucc cuuaauccuc      120

cgacaugcag gaaaguaggc aaguacugaa cugugugaag cucggugaag ucgguugaag      180

guuaccguaa auuaguaucu cuaauacgaa agcuauccag cgguggaugg uguaacugau      240

agaccggagg ucuauaaaac acucaagguu aggaugcgcg augaacuaga ggcgaucgcu      300

aguaagcgca gacgaauccc ugaugguacg ggucuauauc gggagggaau cgaaagguuc      360

ucugacacaa auaagugucg cuacuguggg ugaguaaaac ucuccuuuau gaaagcccau      420

auaucguuac aggcguuauu aagguagcag gcucauaggg gaaaccuaaa aguguaugua      480

cagauaagaa ugacggaacg ugguaagcug ccgacaugga gggcuuguuc ucuuugaagu      540

guugccaagg aaagucacaa ugagauuagu ugucgauaua acuugguuua acggcaguga      600

aagugguggc acaguaccga ugaaacgugu aaugaacgug gagggauagc cacuagucga      660

uugaag                                                                 666


<210>  78
<211>  604
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  78
gugcgacacg uuucuuuaua agugugcaaa cacgaaguag gaggguuauc aauuugauga       60

caacaacgga uugacugcaa guaggaauga aagccgucag guugagcuga aacuacuuau      120

cugauacucc uauaugcaag gcgugauagu agucacaaau uguaugaagc uaggugaagu      180

cggcugaaca aaaccuaagu gagaaaucau augguaaugg auaggucggg augcuacaaa      240

acaucuaugg ugagaauguc cuaacggacu ggcgaaugua cagguuuaaa ggauuaauuc      300

auuagaaaug uguauauugu caacgacgac gcuaucuacc gaaaaguaag aguaaauaau      360

augaaauucg gaagaucuaa cgaugaggau guaaagauaa caggcuuaca gcaagcaccu      420

aaagauauau guauagcuaa gucauucaga acgugguaag caagagacug ucacaaaugc      480

cuacuaacag acaaggugca uauaagguuc uaacgaacca aaauugcuuu auucuuguga      540

agguggggac acaguaccga cgaagcaugu aacaaaugug gagggauagu cccuagucuu      600

guuc                                                                   604


<210>  79
<211>  618
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  79
caauaaaagu gcgaaacguu auccuauaag uaagaaaguu uuaaaauuuu cuuacgaaaa       60

ggauagaacu uaaaaguucu aacuguucua cuaaaguaau aagugaaaau cuuauuuaaa      120

gcaaacaacc aaguagcuuu aagucuaagu ccccuacaca aguuuuauac uacuaugcaa      180

aacuugugaa gcuagguaag gucguaaucc gugaaagucg gaugcggggc uccuuaaaag      240

auuacuaugg uaaacauaag cuaauccauu aagaugcgau uuauauguau uuuauacugu      300

uaaauauuuu aaugcuuuau gguugguaua aaacaguuaa gaugaaguac uuaacugguu      360

uuggaauaau ugguuguuaa acuaaaacau uauaaaucgu uaguggauac cuaagguaau      420

caaaaauagg gauagguaga auggaacguu ugaugcugua uaugaagagg uuuaguagaa      480

ccuaggacac auauacgggc ucagcagguu cauaguagcu augauacuca gccggaaguc      540

aauuaauuuu gaaauacuuc uaugguaaca uaggagaagg auaaaacuga gugagccaag      600

gaaccuaguc gguaauag                                                    618


<210>  80
<211>  618
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  80
caauaaaagu gcgaaacguu auccuauaag uaagaaaguu uuaaaauuuu cuuacgaaaa       60

ggauagaacu uaaaaguucu aacuguucua cuaaaguaau aagugaaaau cuuauuuaaa      120

gcaaacaacc aaguagcuuu aagucuaagu ccccuacaca aguuuuauac uacuaugcaa      180

aacuugugaa gcuagguaag gucguaaucc gugaaagucg gaugcggggc uccuuaaaag      240

auuacuaugg uaaacauaag cuaauccauu aagaugcgau uuauauguau uuuauacugu      300

uaaauauuuu ugugcuuagg gcuugguaua aaacaguuaa gaugaaguac uuaacugguu      360

uuggaauaau ugguuguuaa acuaaaacau uauaaaucgu uaguggauac cuaagguaau      420

caaaaauagg gauagguaga auggaacguu ugaugcugua uaugaagagg uuuaguagaa      480

ccuaggacac auauacgggc ucagcagguu cauaguagcu augauacuca gccggaaguc      540

aauuaauuuu gaaauacuuc uaugguaaca uaggagaagg auaaaacuga gugagccaag      600

gaaccuaguc gguaauag                                                    618


<210>  81
<211>  618
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  81
caauaaaagu gcgaaacguu auccuauaag uaagaaaguu uuaaaauuuu cuuacgaaaa       60

ggauagaacu uaaaaguucu aacuguucua cuaaaguaau aagugaaaau cuuauuuaaa      120

gcaaacaacc aaguagcuuu aagucuaagu ccccuacaca aguuuuauac uacuaugcaa      180

aacuugugaa gcuagguaag gucguaaucc gugaaagucg gaugcggggc uccuuaaaag      240

auuacuaugg uaaacauaag cuaauccauu aagaugcgau uuauauguau uuuauacugu      300

uaaauauuuu ugcucuucaa cguugguaua aaacaguuaa gaugaaguac uuaacugguu      360

uuggaauaau ugguuguuaa acuaaaacau uauaaaucgu uaguggauac cuaagguaau      420

caaaaauagg gauagguaga auggaacguu ugaugcugua uaugaagagg uuuaguagaa      480

ccuaggacac auauacgggc ucagcagguu cauaguagcu augauacuca gccggaaguc      540

aauuaauuuu gaaauacuuc uaugguaaca uaggagaagg auaaaacuga gugagccaag      600

gaaccuaguc gguaauag                                                    618


<210>  82
<211>  618
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  82
caauaaaagu gcgaaacguu auccuauaag uaagaaaguu uuaaaauuuu cuuacgaaaa       60

ggauagaacu uaaaaguucu aacuguucua cuaaaguaau aagugaaaau cuuauuuaaa      120

gcaaacaacc aaguagcuuu aagucuaagu ccccuacaca aguuuuauac uacuaugcaa      180

aacuugugaa gcuagguaag gucguaaucc gugaaagucg gaugcggggc uccuuaaaag      240

auuacuaugg uaaacauaag cuaauccauu aagaugcgau uuauauguau uuuauacugu      300

uaaauauuuu ugugcuugug gcuugguaua aaacaguuaa gaugaaguac uuaacugguu      360

uuggaauaau ugguuguuaa acuaaaacau uauaaaucgu uaguggauac cuaagguaau      420

caaaaauagg gauagguaga auggaacguu ugaugcugua uaugaagagg uuuaguagaa      480

ccuaggacac auauacgggc ucagcagguu cauaguagcu augauacuca gccggaaguc      540

aauuaauuuu gaaauacuuc uaugguaaca uaggagaagg auaaaacuga gugagccaag      600

gaaccuaguc gguaauag                                                    618


<210>  83
<211>  519
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  83
gugcgacuag uaaagugcuu aauaacaaug uggugaaagc ccaccagaua acccauuauc       60

ugagcucaga cgguaugcau uagaaguaau ucuuuugugu aaagcccguu uaauuuggua      120

aacagaccaa ccaaccuaua uauaaggaug gugagcuaua uuacuaugga uaaaauuuuu      180

augaauucac guucgaagcg uauuagagug aguuuuauuu agaaggaaaa aaguaaauaa      240

aauucuaauu aauuguauaa acaauuuuuc guuuguuuau uaaugggucu uauauuaaug      300

uacguauagu gaaauccuaa gguaguaaau aagguguuau uaaguaaacu agguaagccc      360

aauaauaucu ucauaugaua guaugaagaa guucaagugu aaauuugaau auauauuagu      420

ggguaaagga uauuuuaaaa agcgaauguc ucauauuaau agugagaaua gguuuaugac      480

uaauucgaaa gaaugcugac uuaaaauuaa uauuaauau                             519


<210>  84
<211>  525
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  84
gugcgacuag auaaguacuu aauagcaaug uggugaaagu ccaccugaua acccauaguc       60

ugagcucaga cgguaugcau uagaaguaau ucuuuugugu aaagcccguu uaaucugguc      120

uaaaggaccu uccacccuaa auauauaggg ggagagcuau aauacuaagg auaaaauuuu      180

uuugaauuca uguuuaaagc guauuagagg aaauuuauuu cuaugaaaaa gaagaaauaa      240

auuuuuaauu aacuguauaa acaaguuuuc guuuguuuau uagugggucu uauguuaaug      300

uacguauagu ggaauccuaa gguauuaauu aagguguuau uaaguaaacu agguaagccc      360

aauagugucu ucauauuaua auaugaagaa guucaauugu gaaauugaau augcauuagu      420

ggguaaagga uauuuuaaaa agcgaauguc ucauauuaau agugagaaua ggucuaugac      480

uaauucgaaa gaaugcugac uuaaaauugg uauuaauaua ugcgu                      525


<210>  85
<211>  464
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  85
gugcgacuug uuaaguuuua acaaaaauug uauaacguuu auuaaugauu auacauugua       60

uuucaucuua caauagccua auuagauaug cauuuagggu aacuuuuuug uauaaagcuc      120

uaauuauaag uguaaauaca cuuuuaggcu ucuucuaugg uuagagaaau cgaaccaaug      180

uaauuaaaac uuugauguau uaggcauuua acguguccuu gguuaaauga agaugaacau      240

aaguauacaa aguaaaauug gaaccuaagg aagaauuguu uuuguuaaga aacaagguaa      300

uaccuauaac uggcuaauau aaauuugcaa gguuuauugu aaaauaaacu auagguuaga      360

gguaaaagga uaauguaaaa agcgaaugca auucuguaau ggaauugaua ggguauauac      420

cuaacuugaa agagugcuga cuuacauaua gauguuauuu acgu                       464


<210>  86
<211>  538
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  86
gugcgacuag uaaaguguuu aauaauaaug uggugaaaac ccaccagaua acccauuauc       60

ugagcucaua cggugugcau uaaaaguaau uuuuuuguau aaagcccguu uaaucaggua      120

aauaauccuu ccauccuaau uauaucuaua gauauaaaag gauggugagc uauauuacua      180

uggauaagau uuuuuugaau ucacguuuga agcguauuag aguaaguuuu auuuaaaagg      240

aaaaaaaaaa auuaaauaaa auuaaauuaa uuguauaaau aaguuuucgu uuauuuauua      300

augggucuua uauuaaugua cguauaguga aauccuaaug uaguaauuaa gguguuauua      360

aauaaacuag guaagcccaa uaaugucuuc auaauaugaa gaaguucaag uguaaauuug      420

aauauacauu aguggguaaa ggauauuuua aaaagcgaau gucucauauu aauagugaga      480

auaggucuau gacuaauucg aaagaaugcu gacuuaaaau uaauauuaau auuaauau        538


<210>  87
<211>  363
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' intron fragment

<400>  87
caauaaaagu gcgaaacguu auccuauaag uaagaaaguu uuaaaauuuu cuuacgaaaa       60

ggauagaacu uaaaaguucu aacuguucua cuaaaguaau aagugaaaau cuuauuuaaa      120

gcaaacaacc aaguagcuuu aagucuaagu ccccuacaca aguuuuauac uacuaugcaa      180

aacuugugaa gcuagguaag gucguaaucc gugaaagucg gaugcggggc uccuuaaaag      240

auuacuaugg uaaacauaag cuaauccauu aagaugcgau uuauauguau uuuauacugu      300

uaaauauuuu ugugcuugug gcuugguaua aaacaguuaa gaugaaguac uuaacugguu      360

uug                                                                    363


<210>  88
<211>  441
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' intron fragment

<400>  88
caauaaaagu gcgaaacguu auccuauaag uaagaaaguu uuaaaauuuu cuuacgaaaa       60

ggauagaacu uaaaaguucu aacuguucua cuaaaguaau aagugaaaau cuuauuuaaa      120

gcaaacaacc aaguagcuuu aagucuaagu ccccuacaca aguuuuauac uacuaugcaa      180

aacuugugaa gcuagguaag gucguaaucc gugaaagucg gaugcggggc uccuuaaaag      240

auuacuaugg uaaacauaag cuaauccauu aagaugcgau uuauauguau uuuauacugu      300

uaaauauuuu ugugcuugug gcuugguaua aaacaguuaa gaugaaguac uuaacugguu      360

uuggaauaau ugguuguuaa acuaaaacau uauaaaucgu uaguggauac cuaagguaau      420

caaaaauagg gauagguaga a                                                441


<210>  89
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' arm of target sequence

<400>  89
gcaauagccg aaaaacaaaa aacaaaaaaa acaaaaaaaa aaccaaaaaa acaaaacaca       60


<210>  90
<211>  58
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' arm of target sequence

<400>  90
cgaaaggagg aggaggagga aaaaaaggag gaggaggaaa ccaaaaaaac aaaacaca         58


<210>  91
<211>  93
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' arm of target sequence

<400>  91
gcaauggagg aggaggagga aaaaaaggag gaggaggaag ccgaaaaaca aaaaacaaaa       60

aaaacaaaaa aaaaaccaaa aaaacaaaac aca                                    93


<210>  92
<211>  93
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' arm of target sequence

<400>  92
gcaauccucc uccuccuaaa aaaccuccuc cuccuccuag ccgaaaaaca aaaaacaaaa       60

aaaacaaaaa aaaaaccaaa aaaacaaaac aca                                    93


<210>  93
<211>  39
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' arm of target sequence

<400>  93
cgaaaggagg aggaggagga accaaaaaaa caaaacaca                              39


<210>  94
<211>  40
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' arm of target sequence

<400>  94
cgaaaccucc uccuccuccu aaccaaaaaa acaaaacaca                             40


<210>  95
<211>  58
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' arm of target sequence

<400>  95
cgaaaccucc uccuccuaaa aaaccuccuc cuccuccuaa ccaaaaaaac aaaacaca         58


<210>  96
<211>  58
<212>  RNA
<213>  artificial sequence

<220>
<223>  5' arm of target sequence

<400>  96
cgaaaccucc uccuccuaaa aaaccuccuc cuccuccuaa ccaaaaaaac aaaacaca         58


<210>  97
<211>  19
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' arm of target sequence

<400>  97
aaaaaacaaa aaacaaaac                                                    19


<210>  98
<211>  52
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' arm of target sequence

<400>  98
aaaaaacaaa aaacaccucc uccuccuaaa aaaccuccuc cuccuccuaa aa               52


<210>  99
<211>  52
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' arm of target sequence

<400>  99
aaaaaacaaa aaacaccucc uccuccuaaa aaaccuccuc cuccuccuaa ac               52


<210>  100
<211>  52
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' arm of target sequence

<400>  100
aaaaaacaaa aaacaggagg aggaggagga aaaaaaggag gaggaggaaa ac               52


<210>  101
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' arm of target sequence

<400>  101
aaaaaacaaa aaacaccucc uccuccuccu aaaa                                   34


<210>  102
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' arm of target sequence

<400>  102
aaaaaacaaa aaacaggagg aggaggagga aaa                                    33


<210>  103
<211>  51
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' arm of target sequence

<400>  103
aaaaaacaaa aaacaggagg aggaggagga aaaaaaggag gaggaggaaa a                51


<210>  104
<211>  100
<212>  RNA
<213>  artificial sequence

<220>
<223>  3' arm of target sequence

<400>  104
auuagagaca auuugaaaua auuuagauug gcuuaacccu acugugcuaa ccgaaccaga       60

uaacgguaca guagggguaa auucuccgca uucggugcgg                            100


<210>  105
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5' homology arm sequence

<400>  105
aauaccuuac uuaauaguaa                                                   20


<210>  106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' homology arm sequence

<400>  106
uuacuauuaa guaagguauu                                                   20


<210>  107
<211>  558
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  107
augggaguca aaguucuguu ugcccugauc ugcaucgcug uggccgaggc caagcccacc       60

gagaacaacg aagacuucaa caucguggcc guggccagca acuucgcgac cacggaucuc      120

gaugcugacc gcgggaaguu gcccggcaag aagcugccgc uggaggugcu caaagagaug      180

gaagccaaug cccggaaagc uggcugcacc aggggcuguc ugaucugccu gucccacauc      240

aagugcacgc ccaagaugaa gaaguucauc ccaggacgcu gccacaccua cgaaggcgac      300

aaagaguccg cacagggcgg cauaggcgag gcgaucgucg acauuccuga gauuccuggg      360

uucaaggacu uggagcccau ggagcaguuc aucgcacagg ucgaucugug uguggacugc      420

acaacuggcu gccucaaagg gcuugccaac gugcaguguu cugaccugcu caagaagugg      480

cugccgcaac gcugugcgac cuuugccagc aagauccagg gccaggugga caagaucaag      540

ggggccggug gugacuag                                                    558


<210>  108
<211>  720
<212>  RNA
<213>  artificial sequence

<220>
<223>  target sequence

<400>  108
auggugagca agggcgagga gcuguucacc gggguggugc ccauccuggu cgagcuggac       60

ggcgacguaa acggccacaa guucagcgug uccggcgagg gcgagggcga ugccaccuac      120

ggcaagcuga cccugaaguu caucugcacc accggcaagc ugcccgugcc cuggcccacc      180

cucgugacca cccugaccua cggcgugcag ugcuucagcc gcuaccccga ccacaugaag      240

cagcacgacu ucuucaaguc cgccaugccc gaaggcuacg uccaggagcg caccaucuuc      300

uucaaggacg acggcaacua caagacccgc gccgagguga aguucgaggg cgacacccug      360

gugaaccgca ucgagcugaa gggcaucgac uucaaggagg acggcaacau ccuggggcac      420

aagcuggagu acaacuacaa cagccacaac gucuauauca uggccgacaa gcagaagaac      480

ggcaucaagg ugaacuucaa gauccgccac aacaucgagg acggcagcgu gcagcucgcc      540

gaccacuacc agcagaacac ccccaucggc gacggccccg ugcugcugcc cgacaaccac      600

uaccugagca cccaguccgc ccugagcaaa gaccccaacg agaagcgcga ucacaugguc      660

cugcuggagu ucgugaccgc cgccgggauc acucucggca uggacgagcu guacaaguag      720


<210>  109
<211>  936
<212>  RNA
<213>  artificial sequence

<220>
<223>  target sequence

<400>  109
auggcuucca agguguacga ccccgagcaa cgcaaacgca ugaucacugg gccucagugg       60

ugggcucgcu gcaagcaaau gaacgugcug gacuccuuca ucaacuacua ugauuccgag      120

aagcacgccg agaacgccgu gauuuuucug caugguaacg cugccuccag cuaccugugg      180

aggcacgucg ugccucacau cgagcccgug gcuagaugca ucaucccuga ucugaucgga      240

auggguaagu ccggcaagag cgggaauggc ucauaucgcc uccuggauca cuacaaguac      300

cucaccgcuu gguucgagcu gcugaaccuu ccaaagaaaa ucaucuuugu gggccacgac      360

uggggggcuu gucuggccuu ucacuacucc uacgagcacc aagacaagau caaggccauc      420

guccaugcug agagugucgu ggacgugauc gaguccuggg acgaguggcc ugacaucgag      480

gaggauaucg cccugaucaa gagcgaagag ggcgagaaaa uggugcuuga gaauaacuuc      540

uucgucgaga ccaugcuccc aagcaagauc augcggaaac uggagccuga ggaguucgcu      600

gccuaccugg agccauucaa ggagaagggc gagguuagac ggccuacccu cuccuggccu      660

cgcgagaucc cucucguuaa gggaggcaag cccgacgucg uccagauugu ccgcaacuac      720

aacgccuacc uucgggccag cgacgaucug ccuaagaugu ucaucgaguc cgacccuggg      780

uucuuuucca acgcuauugu cgagggagcu aagaaguucc cuaacaccga guucgugaag      840

gugaagggcc uccacuucag ccaggaggac gcuccagaug aaauggguaa guacaucaag      900

agcuucgugg agcgcgugcu gaagaacgag caguaa                                936


<210>  110
<211>  1653
<212>  RNA
<213>  artificial sequence

<220>
<223>  target sequence

<400>  110
auggccgaug cuaagaacau uaagaagggc ccugcucccu ucuacccucu ggaggauggc       60

accgcuggcg agcagcugca caaggccaug aagagguaug cccuggugcc uggcaccauu      120

gccuucaccg augcccacau ugagguggac aucaccuaug ccgaguacuu cgagaugucu      180

gugcgccugg ccgaggccau gaagagguac ggccugaaca ccaaccaccg caucguggug      240

ugcucugaga acucucugca guucuucaug ccagugcugg gcgcccuguu caucggagug      300

gccguggccc cugcuaacga cauuuacaac gagcgcgagc ugcugaacag caugggcauu      360

ucucagccua ccgugguguu cgugucuaag aagggccugc agaagauccu gaacgugcag      420

aagaagcugc cuaucaucca gaagaucauc aucauggacu cuaagaccga cuaccagggc      480

uuccagagca uguacacauu cgugacaucu caucugccuc cuggcuucaa cgaguacgac      540

uucgugccag agucuuucga cagggacaaa accauugccc ugaucaugaa cagcucuggg      600

ucuaccggcc ugccuaaggg cguggcccug ccucaucgca ccgccugugu gcgcuucucu      660

cacgcccgcg acccuauuuu cggcaaccag aucauccccg acaccgcuau ucugagcgug      720

gugccauucc accacggcuu cggcauguuc accacccugg gcuaccugau uugcggcuuu      780

cggguggugc ugauguaccg cuucgaggag gagcuguucc ugcgcagccu gcaagacuac      840

aaaauucagu cugcccugcu ggugccaacc cuguucagcu ucuucgcuaa gagcacccug      900

aucgacaagu acgaccuguc uaaccugcac gagauugccu cuggcggcgc cccacugucu      960

aaggaggugg gcgaagccgu ggccaagcgc uuucaucugc caggcauccg ccagggcuac     1020

ggccugaccg agacaaccag cgccauucug auuaccccag agggcgacga caagccuggc     1080

gccgugggca agguggugcc auucuucgag gccaaggugg uggaccugga caccggcaag     1140

acccugggag ugaaccagcg cggcgagcug ugugugcgcg gcccuaugau uauguccggc     1200

uacgugaaua acccugaggc cacaaacgcc cugaucgaca aggacggcug gcugcacucu     1260

ggcgacauug ccuacuggga cgaggacgag cacuucuuca ucguggaccg ccugaagucu     1320

cugaucaagu acaagggcua ccagguggcc ccagccgagc uggagucuau ccugcugcag     1380

cacccuaaca uuuucgacgc cggaguggcc ggccugcccg acgacgaugc cggcgagcug     1440

ccugccgccg ucgucgugcu ggaacacggc aagaccauga ccgagaagga gaucguggac     1500

uauguggcca gccaggugac aaccgccaag aagcugcgcg gcggaguggu guucguggac     1560

gaggugccca agggccugac cggcaagcug gacgcccgca agauccgcga gauccugauc     1620

aaggcuaaga aaggcggcaa gaucgccgug uaa                                  1653


<210>  111
<211>  816
<212>  RNA
<213>  artificial sequence

<220>
<223>  target sequence

<400>  111
auggacgcca ugaaacgggg acugugcugc gugcugcugc uguguggcgc cguguucgug       60

ucaccuagcc gggugcagcc uaccgagagc aucgugcggu ucccuaacau cacaaaccug      120

uguccauucg gcgagguguu caacgccacc agauucgcca gcguguacgc uuggaauaga      180

aaaagaaucu cuaauugcgu ggccgauuac agcgugcugu acaacagcgc cuccuucagc      240

accuucaagu gcuacggcgu gucccccacc aagcugaacg accugugcuu cacaaauguc      300

uacgccgaua gcuucgugau uagaggcgac gaggugaggc agaucgcucc aggccagacc      360

ggcaagaucg cugauuacaa cuacaagcug ccugaugacu ucacaggaug ugugaucgcc      420

uggaacagca acaaccucga cagcaaggug ggaggcaacu acaauuaccu guauagacug      480

uucagaaagu ccaaccugaa gcccuucgag agagacauca gcaccgaaau cuaccaggcc      540

ggcuccaccc cuugcaacgg aguggaaggc uucaacugcu acuucccccu gcagagcuac      600

gguuuucagc cuaccaacgg cgugggcuac cagcccuacc gcgugguugu gcugagcuuc      660

gagcugcugc acgccccagc uacagugugc ggcccuaaga aaucuaccaa ccuggugaag      720

aacaagggcu auauccccga ggccccuaga gacggccaag ccuacgugcg gaaggacggc      780

gaaugggucc ugcucagcac auuccugggc agcuga                                816


<210>  112
<211>  3345
<212>  RNA
<213>  artificial sequence

<220>
<223>  target sequence

<400>  112
auggccccaa agaagaagcg gaaggucggu auccacggag ucccagcagc caagcggaac       60

uacauccugg gccuggacau cggcaucacc agcgugggcu acggcaucau cgacuacgag      120

acacgggacg ugaucgaugc cggcgugcgg cuguucaaag aggccaacgu ggaaaacaac      180

gagggcaggc ggagcaagag aggcgccaga aggcugaagc ggcggaggcg gcauagaauc      240

cagagaguga agaagcugcu guucgacuac aaccugcuga ccgaccacag cgagcugagc      300

ggcaucaacc ccuacgaggc cagagugaag ggccugagcc agaagcugag cgaggaagag      360

uucucugccg cccugcugca ccuggccaag agaagaggcg ugcacaacgu gaacgaggug      420

gaagaggaca ccggcaacga gcuguccacc aaagagcaga ucagccggaa cagcaaggcc      480

cuggaagaga aauacguggc cgaacugcag cuggaacggc ugaagaaaga cggcgaagug      540

cggggcagca ucaacagauu caagaccagc gacuacguga aagaagccaa acagcugcug      600

aaggugcaga aggccuacca ccagcuggac cagagcuuca ucgacaccua caucgaccug      660

cuggaaaccc ggcggaccua cuaugaggga ccuggcgagg gcagccccuu cggcuggaag      720

gacaucaaag aaugguacga gaugcugaug ggccacugca ccuacuuccc cgaggaacug      780

cggagcguga aguacgccua caacgccgac cuguacaacg cccugaacga ccugaacaau      840

cucgugauca ccagggacga gaacgagaag cuggaauauu acgagaaguu ccagaucauc      900

gagaacgugu ucaagcagaa gaagaagccc acccugaagc agaucgccaa agaaauccuc      960

gugaacgaag aggauauuaa gggcuacaga gugaccagca ccggcaagcc cgaguucacc     1020

aaccugaagg uguaccacga caucaaggac auuaccgccc ggaaagagau uauugagaac     1080

gccgagcugc uggaucagau ugccaagauc cugaccaucu accagagcag cgaggacauc     1140

caggaagaac ugaccaaucu gaacuccgag cugacccagg aagagaucga gcagaucucu     1200

aaucugaagg gcuauaccgg cacccacaac cugagccuga aggccaucaa ccugauccug     1260

gacgagcugu ggcacaccaa cgacaaccag aucgcuaucu ucaaccggcu gaagcuggug     1320

cccaagaagg uggaccuguc ccagcagaaa gagaucccca ccacccuggu ggacgacuuc     1380

auccugagcc ccgucgugaa gagaagcuuc auccagagca ucaaagugau caacgccauc     1440

aucaagaagu acggccugcc caacgacauc auuaucgagc uggcccgcga gaagaacucc     1500

aaggacgccc agaaaaugau caacgagaug cagaagcgga accggcagac caacgagcgg     1560

aucgaggaaa ucauccggac caccggcaaa gagaacgcca aguaccugau cgagaagauc     1620

aagcugcacg acaugcagga aggcaagugc cuguacagcc uggaagccau cccucuggaa     1680

gaucugcuga acaaccccuu caacuaugag guggaccaca ucauccccag aagcgugucc     1740

uucgacaaca gcuucaacaa caaggugcuc gugaagcagg aagaaaacag caagaagggc     1800

aaccggaccc cauuccagua ccugagcagc agcgacagca agaucagcua cgaaaccuuc     1860

aagaagcaca uccugaaucu ggccaagggc aagggcagaa ucagcaagac caagaaagag     1920

uaucugcugg aagaacggga caucaacagg uucuccgugc agaaagacuu caucaaccgg     1980

aaccuggugg auaccagaua cgccaccaga ggccugauga accugcugcg gagcuacuuc     2040

agagugaaca accuggacgu gaaagugaag uccaucaaug gcggcuucac cagcuuucug     2100

cggcggaagu ggaaguuuaa gaaagagcgg aacaaggggu acaagcacca cgccgaggac     2160

gcccugauca uugccaacgc cgauuucauc uucaaagagu ggaagaaacu ggacaaggcc     2220

aaaaaaguga uggaaaacca gauguucgag gaaaagcagg ccgagagcau gcccgagauc     2280

gaaaccgagc aggaguacaa agagaucuuc aucacccccc accagaucaa gcacauuaag     2340

gacuucaagg acuacaagua cagccaccgg guggacaaga agccuaauag agagcugauu     2400

aacgacaccc uguacuccac ccggaaggac gacaagggca acacccugau cgugaacaau     2460

cugaacggcc uguacgacaa ggacaaugac aagcugaaaa agcugaucaa caagagcccc     2520

gaaaagcugc ugauguacca ccacgacccc cagaccuacc agaaacugaa gcugauuaug     2580

gaacaguacg gcgacgagaa gaauccccug uacaaguacu acgaggaaac cgggaacuac     2640

cugaccaagu acuccaaaaa ggacaacggc cccgugauca agaagauuaa guauuacggc     2700

aacaaacuga acgcccaucu ggacaucacc gacgacuacc ccaacagcag aaacaagguc     2760

gugaagcugu cccugaagcc cuacagauuc gacguguacc uggacaaugg cguguacaag     2820

uucgugaccg ugaagaaucu ggaugugauc aaaaaagaaa acuacuacga agugaauagc     2880

aagugcuaug aggaagcuaa gaagcugaag aagaucagca accaggccga guuuaucgcc     2940

uccuucuaca acaacgaucu gaucaagauc aacggcgagc uguauagagu gaucggcgug     3000

aacaacgacc ugcugaaccg gaucgaagug aacaugaucg acaucaccua ccgcgaguac     3060

cuggaaaaca ugaacgacaa gaggcccccc aggaucauua agacaaucgc cuccaagacc     3120

cagagcauua agaaguacag cacagacauu cugggcaacc uguaugaagu gaaaucuaag     3180

aagcacccuc agaucaucaa aaagggcaaa aggccggcgg ccacgaaaaa ggccggccag     3240

gcaaaaaaga aaaagggauc cuacccauac gauguuccag auuacgcuua cccauacgau     3300

guuccagauu acgcuuaccc auacgauguu ccagauuacg cuuaa                     3345


<210>  113
<211>  185
<212>  PRT
<213>  artificial sequence

<220>
<223>  target sequence

<400>  113

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala 
            20                  25                  30          


Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro 
        35                  40                  45              


Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala 
    50                  55                  60                  


Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile 
65                  70                  75                  80  


Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr 
                85                  90                  95      


Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile 
            100                 105                 110         


Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Met Glu 
        115                 120                 125             


Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys 
    130                 135                 140                 


Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp 
145                 150                 155                 160 


Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val 
                165                 170                 175     


Asp Lys Ile Lys Gly Ala Gly Gly Asp 
            180                 185 


<210>  114
<211>  239
<212>  PRT
<213>  artificial sequence

<220>
<223>  target sequence

<400>  114

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  115
<211>  311
<212>  PRT
<213>  artificial sequence

<220>
<223>  target sequence

<400>  115

Met Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln 
305                 310     


<210>  116
<211>  550
<212>  PRT
<213>  artificial sequence

<220>
<223>  target sequence

<400>  116

Met Ala Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val 
545                 550 


<210>  117
<211>  271
<212>  PRT
<213>  artificial sequence

<220>
<223>  target sequence

<400>  117

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser Arg Val Gln Pro Thr Glu Ser Ile Val 
            20                  25                  30          


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        35                  40                  45              


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    50                  55                  60                  


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
65                  70                  75                  80  


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                85                  90                  95      


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
            100                 105                 110         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        115                 120                 125             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
    130                 135                 140                 


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
145                 150                 155                 160 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                165                 170                 175     


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
            180                 185                 190         


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
        195                 200                 205             


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
    210                 215                 220                 


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
225                 230                 235                 240 


Asn Lys Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
                245                 250                 255     


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser 
            260                 265                 270     


<210>  118
<211>  1114
<212>  PRT
<213>  artificial sequence

<220>
<223>  target sequence

<400>  118

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
            20                  25                  30          


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
        35                  40                  45              


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
    50                  55                  60                  


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
65                  70                  75                  80  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
                85                  90                  95      


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
            100                 105                 110         


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
        115                 120                 125             


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
    130                 135                 140                 


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
145                 150                 155                 160 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
                165                 170                 175     


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
            180                 185                 190         


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
        195                 200                 205             


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
    210                 215                 220                 


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
225                 230                 235                 240 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
                245                 250                 255     


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
            260                 265                 270         


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
        275                 280                 285             


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
    290                 295                 300                 


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
305                 310                 315                 320 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
                325                 330                 335     


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
            340                 345                 350         


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
        355                 360                 365             


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
    370                 375                 380                 


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
385                 390                 395                 400 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
                405                 410                 415     


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
            420                 425                 430         


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
        435                 440                 445             


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
    450                 455                 460                 


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
465                 470                 475                 480 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
                485                 490                 495     


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
            500                 505                 510         


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
        515                 520                 525             


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
    530                 535                 540                 


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
545                 550                 555                 560 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
                565                 570                 575     


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
            580                 585                 590         


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
        595                 600                 605             


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
    610                 615                 620                 


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
625                 630                 635                 640 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
                645                 650                 655     


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
            660                 665                 670         


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
        675                 680                 685             


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
    690                 695                 700                 


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
705                 710                 715                 720 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
                725                 730                 735     


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
            740                 745                 750         


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
        755                 760                 765             


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
    770                 775                 780                 


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
785                 790                 795                 800 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
                805                 810                 815     


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
            820                 825                 830         


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
        835                 840                 845             


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
    850                 855                 860                 


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
865                 870                 875                 880 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
                885                 890                 895     


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
            900                 905                 910         


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
        915                 920                 925             


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
    930                 935                 940                 


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
945                 950                 955                 960 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
                965                 970                 975     


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
            980                 985                 990         


Glu Leu Tyr Arg Val Ile Gly Val  Asn Asn Asp Leu Leu  Asn Arg Ile 
        995                 1000                 1005             


Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg Glu Tyr  Leu Glu Asn 
    1010                 1015                 1020             


Met Asn  Asp Lys Arg Pro Pro  Arg Ile Ile Lys Thr  Ile Ala Ser 
    1025                 1030                 1035             


Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr Asp Ile  Leu Gly Asn 
    1040                 1045                 1050             


Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro Gln Ile  Ile Lys Lys 
    1055                 1060                 1065             


Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1070                 1075                 1080             


Lys Lys  Gly Ser Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala Tyr Pro 
    1085                 1090                 1095             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1100                 1105                 1110             


Ala 
    


<210>  119
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  EBS1

<400>  119
uagggc                                                                   6


<210>  120
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  EBS1

<400>  120
uuaugg                                                                   6


<210>  121
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  EBS1

<400>  121
ucaacg                                                                   6


<210>  122
<211>  6
<212>  RNA
<213>  artificial sequence

<220>
<223>  EBS1

<400>  122
uguggc                                                                   6


<210>  123
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1

<400>  123
gcccug                                                                   6


<210>  124
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1

<400>  124
ccaugg                                                                   6


<210>  125
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1

<400>  125
cguuga                                                                   6


<210>  126
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1

<400>  126
gccaua                                                                   6


<210>  127
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>   and its upstream sequence

<400>  127
ugugcu                                                                   6


<210>  128
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>   and its upstream sequence

<400>  128
aaugcu                                                                   6


<210>  129
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>   and its upstream sequence

<400>  129
ugcucu                                                                   6


<210>  130
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>   and its upstream sequence

<400>  130
ugugcu                                                                   6


<210>  131
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1 and its downstream

<400>  131
agcaaa                                                                   6


<210>  132
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1 and its downstream

<400>  132
agcagu                                                                   6


<210>  133
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1 and its downstream

<400>  133
agagaa                                                                   6


<210>  134
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IBS1 and its downstream

<400>  134
agcaaa                                                                   6


