                         SEQUENCE LISTING

<110>  BEIJING ANXINHUAIDE BIOTECH.CO., LTD
 
<120>  A SUPER-TRAIL MOLECULE COMPRISING TWO TRAIL TRIMERS

<130>  P11151-PCT

<150>  PCT/CN2021/096498
<151>  2021-05-27

<160>  11    

<170>  PatentIn version 3.3

<210>  1
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  2
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1611 protein sequence

<400>  2

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Gly Gly Val Ala Ala 
                165                 170                 175     


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
            180                 185                 190         


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
        195                 200                 205             


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
    210                 215                 220                 


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
225                 230                 235                 240 


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
                245                 250                 255     


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
            260                 265                 270         


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
        275                 280                 285             


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
    290                 295                 300                 


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
305                 310                 315                 320 


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                325                 330             


<210>  3
<211>  334
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1621 protein sequence

<400>  3

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Val Ala 
                165                 170                 175     


Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
            180                 185                 190         


Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
        195                 200                 205             


Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
    210                 215                 220                 


Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
225                 230                 235                 240 


Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
                245                 250                 255     


Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
            260                 265                 270         


Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
        275                 280                 285             


Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
    290                 295                 300                 


Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
305                 310                 315                 320 


Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                325                 330                 


<210>  4
<211>  334
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1631 protein sequence

<400>  4

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Gly Gly Gly Val Ala 
                165                 170                 175     


Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
            180                 185                 190         


Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
        195                 200                 205             


Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
    210                 215                 220                 


Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
225                 230                 235                 240 


Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
                245                 250                 255     


Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
            260                 265                 270         


Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
        275                 280                 285             


Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
    290                 295                 300                 


Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
305                 310                 315                 320 


Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                325                 330                 


<210>  5
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1622 protein sequence

<400>  5

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                325                 330                 335 


<210>  6
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1623 protein sequence

<400>  6

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
            180                 185                 190         


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
        195                 200                 205             


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
    210                 215                 220                 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
225                 230                 235                 240 


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
                245                 250                 255     


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
            260                 265                 270         


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
        275                 280                 285             


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
    290                 295                 300                 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
305                 310                 315                 320 


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                325                 330                 335     


<210>  7
<211>  336
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1630 protein sequence

<400>  7

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                165                 170                 175     


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
            180                 185                 190         


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
        195                 200                 205             


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
    210                 215                 220                 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
225                 230                 235                 240 


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
                245                 250                 255     


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
            260                 265                 270         


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
        275                 280                 285             


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
    290                 295                 300                 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
305                 310                 315                 320 


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                325                 330                 335     


<210>  8
<211>  337
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1632 protein sequence

<400>  8

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                165                 170                 175     


Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
            180                 185                 190         


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
        195                 200                 205             


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
    210                 215                 220                 


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
225                 230                 235                 240 


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
                245                 250                 255     


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
            260                 265                 270         


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
        275                 280                 285             


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
    290                 295                 300                 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
305                 310                 315                 320 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
                325                 330                 335     


Gly 
    


<210>  9
<211>  339
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1618 protein sequence

<400>  9

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
            180                 185                 190         


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
        195                 200                 205             


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
    210                 215                 220                 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
225                 230                 235                 240 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
                245                 250                 255     


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
            260                 265                 270         


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
        275                 280                 285             


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
    290                 295                 300                 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
305                 310                 315                 320 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
                325                 330                 335     


Leu Val Gly 
            


<210>  10
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1620 protein sequence

<400>  10

Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
1               5                   10                  15      


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
            20                  25                  30          


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
        35                  40                  45              


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
    50                  55                  60                  


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
65                  70                  75                  80  


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
                85                  90                  95      


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
            100                 105                 110         


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
        115                 120                 125             


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
    130                 135                 140                 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
145                 150                 155                 160 


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Ser Gly Gly Val Ala Ala His Ile Thr Gly Thr Arg 
            180                 185                 190         


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
        195                 200                 205             


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
    210                 215                 220                 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
225                 230                 235                 240 


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
                245                 250                 255     


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
            260                 265                 270         


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
        275                 280                 285             


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
    290                 295                 300                 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
305                 310                 315                 320 


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
                325                 330                 335     


Phe Gly Ala Phe Leu Val Gly 
            340             


<210>  11
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  super-TRAIL AX-1606 protein sequence

<400>  11

Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
1               5                   10                  15      


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
            20                  25                  30          


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
        35                  40                  45              


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
    50                  55                  60                  


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
65                  70                  75                  80  


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
                85                  90                  95      


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
            100                 105                 110         


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
        115                 120                 125             


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
    130                 135                 140                 


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
145                 150                 155                 160 


Val Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Arg Val 
                165                 170                 175     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            180                 185                 190         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        195                 200                 205             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    210                 215                 220                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
225                 230                 235                 240 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                245                 250                 255     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            260                 265                 270         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        275                 280                 285             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    290                 295                 300                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
305                 310                 315                 320 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                325                 330                 335 


