                         SEQUENCE LISTING

<110>  Precision Biologics, Inc.

<120>  Methods and Compositions for Treating Hematological Malignancies

<130>  1143282.004800

<140>  TBD
<141>  Herewith

<160>  39

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  2

Gly Ala Ser Asn Leu Ala Asp 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  3

Gln Asn Val Leu Ser Ser Pro Tyr Thr 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Ala Ser Asn Leu Ala Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Gln Val Leu Ser Ser Pro Tyr Thr 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Tyr Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  8

Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr 
1               5                   10          


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr 
1               5                   10          


<210>  12
<211>  965
<212>  DNA
<213>  Mus musculus

<400>  12
gcggggcagc ctcacacaga acacacacag atatgggtgt acccactcag ctcctgttgc       60

tgtggcttac agtcgtagtt gtcagatgtg acatccagat gactcagtct ccagcttcac      120

tgtctgcatc tgtgggagaa actgtcacca tcacatgtgg agcaagtgag aatatttacg      180

gtgctttaaa ttggtatcag cggaaacagg gaaaatctcc tcagctcctg atttatggcg      240

caagtaattt ggcagatggc atgtcatcga ggttcagtgg cagtggatct ggtagacagt      300

attctctcaa gatcagtagc ctgcatcctg acgatgttgc aacgtattac tgtcaaaatg      360

tattaagtag tccgtacacg ttcggagggg ggaccaagct ggaaataaaa cgggctgatg      420

ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct ggaggtgcct      480

cagtcgtgtg cttcttgaac aacttctacc ccaaagacat caatgtcaag tggaagattg      540

atggcagtga acgacaaaat ggcgtcctga acagttggac tgatcaggac agcaaagaca      600

gcacctacag catgagcagc accctcacgt tgaccaagga cgagtatgaa cgacataaca      660

gctatacctg tgaggccact cacaagacac caacttcacc cattgtcaag agcttcaaca      720

ggaatgagtg ttagagacaa aggtcctgag acgccaccac cagctcccca gctccatcct      780

atcttccctt ctaaggtctt ggaggcttcc ccacaagcga cctaccactg ttgcggtgct      840

ccaaacctcc tccccacctc cttctcctcc tcctcccttt ccttggcttt tatcatgcta      900

atatttgcag aaaatattca ataaagtgag tctttgcaca aaaaaaaaaa aaaaaaaaaa      960

aaaaa                                                                  965


<210>  13
<211>  1575
<212>  DNA
<213>  Mus musculus

<400>  13
acgcgggaca cagtagtctc tacagtcaca ggagtacaca ggacattgcc atgggttgga       60

gctgtatcat cttctttctg gtagcaacag ctacaggtgt gcactcccag gtccagctgc      120

agcagtctgg gcctgaggtg gtgaggcctg gggtctcagt gaagatttcc tgcaagggtt      180

ccggctacac attcactgat tatgctatgc actgggtgaa gcagagtcat gcaaagagtc      240

tcgagtggat tggacttatt agtacttaca gtggtgatac aaagtacaac cagaacttta      300

agggcaaggc cacaatgact gtagacaaat cctccaacac agcctatatg gaacttgcca      360

gattgacatc tgaggattct gccatctatt actgtgcaag aggggattat tccggtagta      420

ggtactggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca gccaaaacga      480

cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac tccatggtga      540

ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc tggaactctg      600

gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac ctctacactc      660

tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc acctgcaacg      720

ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg gattgtggtt      780

gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc cccccaaagc      840

ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg gtagacatca      900

gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag gtgcacacag      960

ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc agtgaacttc     1020

ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc aacagtgcag     1080

ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg aaggctccac     1140

aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc agtctgacct     1200

gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg aatgggcagc     1260

cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct tacttcgtct     1320

acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc acctgctctg     1380

tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac tctcctggta     1440

aatgatccca gtgtccttgg agccctctgg ccctacagga ctttgacacc tacctccacc     1500

cctccctgta taaataaagc acccagcact gcctcgggac cctgcataaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaa                                                      1575


<210>  14
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  14

Leu Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu Thr 
1               5                   10                  15      


Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn 
            20                  25                  30          


Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile Tyr Gly 
        35                  40                  45              


Ala Ser Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro Asp Asp 
65                  70                  75                  80  


Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Ser Pro Tyr Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Lys Gly 
            100                 105         


<210>  15
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  15

Leu Glu Glu Ser Gly Pro Glu Val Val Arg Pro Gly Val Ser Val Lys 
1               5                   10                  15      


Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr Ala Met His 
            20                  25                  30          


Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Leu Ile 
        35                  40                  45              


Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe Lys Gly Lys 
    50                  55                  60                  


Ala Thr Met Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr Met Glu Leu 
65                  70                  75                  80  


Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg Gly 
                85                  90                  95      


Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Arg 
        115     


<210>  16
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Asp Gly Met Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Gln Tyr Ser Leu Lys Ile Ser Ser Leu His Pro 
65                  70                  75                  80  


Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Gln Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Gln Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  19
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Thr Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  20
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Thr Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Gln Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Asp Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Gln Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  22
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  23
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  24
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  25
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  26
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Val His Ala Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* heavy chain)

<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (20)..(140)
<223>  Variable region

<220>
<221>  MISC_FEATURE
<222>  (141)..(470)
<223>  Constant region

<220>
<221>  MISC_FEATURE
<222>  (45)..(54)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (70)..(85)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (118)..(129)
<223>  CDR3


<400>  28

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  29
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* light chain)

<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Leader sequence

<220>
<221>  MISC_FEATURE
<222>  (20)..(127)
<223>  Variable region

<220>
<221>  MISC_FEATURE
<222>  (128)..(233)
<223>  Constant region

<220>
<221>  MISC_FEATURE
<222>  (43)..(53)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (69)..(75)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (108)..(116)
<223>  CDR3


<400>  29

Met Gly Val Pro Thr Gln Leu Leu Leu Leu Trp Leu Thr Val Val Val 
1               5                   10                  15      


Val Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile 
        35                  40                  45              


Tyr Gly Ala Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Gly Ala Ser Asn Leu Ala Thr Gly Met Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Leu Ser 
            100                 105                 110         


Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  30
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  30

Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 


<210>  31
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence

<400>  31

Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 


<210>  32
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* heavy chain CDR1)

<400>  32

Gly Tyr Thr Phe Thr Asp Tyr Ala Met His
1               5                   10


<210>  33
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* heavy chain CDR2)

<400>  33

Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe Gln Gly
1               5                   10                  15      


<210>  34
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* heavy chain CDR3)

<400>  34

Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr
1               5                   10         


<210>  35
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* light chain CDR1)

<400>  35

Gln Ala Ser Glu Asn Ile Tyr Gly Ala Leu Asn
1               5                   10     


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* light chain CDR2)

<400>  36

Gly Ala Ser Asn Leu Ala Thr
1               5          

<210>  37
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* light chain CDR3)

<400>  37

Gln Gln Val Leu Ser Ser Pro Tyr Thr
1               5                  


<210>  38
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* heavy chain variable)

<220>
<221>  MISC_FEATURE
<222>  (26)..(35)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (51)..(66)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (99)..(110)
<223>  CDR3


<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          

Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              



Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     



<210>  39
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized antibody sequence (h16C3-Abb* light chain)

<220>
<221>  MISC_FEATURE
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  MISC_FEATURE
<222>  (89)..(97)
<223>  CDR3


<400>  39


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Thr Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             

