                               SEQUENCE LISTING

<110> ACHELOIS BIOPHARMA, INC.
 
<120> IMMUNE CHECKPOINT MULTIVALENT PARTICLES COMPOSITIONS AND METHODS
      OF USE

<130> 48295-702.601

<140> PCT/US2022/030012
<141> 2022-05-19

<150> 63/191,031
<151> 2021-05-20

<160> 163   

<170> PatentIn version 3.5

<210> 1
<211> 169
<212> PRT
<213> Mus musculus

<400> 1
Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          


Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  


Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  


Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      


Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 


Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Lys Pro Glu Gly Arg Phe Gln Gly Met 
                165                 


<210> 2
<211> 288
<212> PRT
<213> Homo sapiens

<400> 2
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 3
<211> 223
<212> PRT
<213> Mus musculus

<400> 3
Met Ala Cys Leu Gly Leu Arg Arg Tyr Lys Ala Gln Leu Gln Leu Pro 
1               5                   10                  15      


Ser Arg Thr Trp Pro Phe Val Ala Leu Leu Thr Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala 
        35                  40                  45              


Ser Ser His Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His 
    50                  55                  60                  


Asn Thr Asp Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln 
65                  70                  75                  80  


Met Thr Glu Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly 
                85                  90                  95      


Phe Leu Asp Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Val Ala Val Ser Leu Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Val Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210> 4
<211> 223
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210> 5
<211> 468
<212> PRT
<213> Mus musculus

<400> 5
Met Gly Glu Asp Leu Leu Leu Gly Phe Leu Leu Leu Gly Leu Leu Trp 
1               5                   10                  15      


Glu Ala Pro Val Val Ser Ser Gly Pro Gly Lys Glu Leu Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Val His Leu Pro Cys Ser Leu Lys Ser 
        35                  40                  45              


Pro Asn Leu Asp Pro Asn Phe Leu Arg Arg Gly Gly Val Ile Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Gln Pro Thr Pro Ile Pro Ala Leu Asp Leu 
65                  70                  75                  80  


His Gln Gly Met Pro Ser Pro Arg Gln Pro Ala Pro Gly Arg Tyr Thr 
                85                  90                  95      


Val Leu Ser Val Ala Pro Gly Gly Leu Arg Ser Gly Arg Gln Pro Leu 
            100                 105                 110         


His Pro His Val Gln Leu Glu Glu Arg Gly Leu Gln Arg Gly Asp Phe 
        115                 120                 125             


Ser Leu Trp Leu Arg Pro Ala Leu Arg Thr Asp Ala Gly Glu Tyr His 
    130                 135                 140                 


Ala Thr Val Arg Leu Pro Asn Arg Ala Leu Ser Cys Ser Leu Arg Leu 
145                 150                 155                 160 


Arg Val Gly Gln Ala Ser Met Ile Ala Ser Pro Ser Gly Val Leu Lys 
                165                 170                 175     


Leu Ser Asp Trp Val Leu Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg 
            180                 185                 190         


Pro Val Ser Val His Trp Phe Gln Gly Gln Asn Arg Val Pro Val Tyr 
        195                 200                 205             


Asn Ser Pro Arg His Phe Leu Ala Glu Thr Phe Leu Leu Leu Pro Gln 
    210                 215                 220                 


Val Ser Pro Leu Asp Ser Gly Thr Trp Gly Cys Val Leu Thr Tyr Arg 
225                 230                 235                 240 


Asp Gly Phe Asn Val Ser Ile Thr Tyr Asn Leu Lys Val Leu Gly Leu 
                245                 250                 255     


Glu Pro Val Ala Pro Leu Thr Val Tyr Ala Ala Glu Gly Ser Arg Val 
            260                 265                 270         


Glu Leu Pro Cys His Leu Pro Pro Gly Val Gly Thr Pro Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Glu Leu Pro Val Ala 
    290                 295                 300                 


Gly Lys Ser Gly Asn Phe Thr Leu His Leu Glu Ala Val Gly Leu Ala 
305                 310                 315                 320 


Gln Ala Gly Thr Tyr Thr Cys Ser Ile His Leu Gln Gly Gln Gln Leu 
                325                 330                 335     


Asn Ala Thr Val Thr Leu Ala Val Ile Thr Val Thr Pro Lys Ser Phe 
            340                 345                 350         


Gly Leu Pro Gly Ser Arg Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
        355                 360                 365             


Ser Gly Lys Glu Arg Phe Val Trp Arg Pro Leu Asn Asn Leu Ser Arg 
    370                 375                 380                 


Ser Cys Pro Gly Pro Val Leu Glu Ile Gln Glu Ala Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Arg Trp Gln Cys Gln Leu Tyr Glu Gly Gln Arg Leu Leu Gly Ala 
                405                 410                 415     


Thr Val Tyr Ala Ala Glu Ser Ser Ser Gly Ala His Ser Ala Arg Arg 
            420                 425                 430         


Ile Ser Gly Asp Leu Lys Gly Gly His Leu Val Leu Val Leu Ile Leu 
        435                 440                 445             


Gly Ala Leu Ser Leu Phe Leu Leu Val Ala Gly Ala Phe Gly Phe His 
    450                 455                 460                 


Lys Arg Ile Gln 
465             


<210> 6
<211> 525
<212> PRT
<213> Homo sapiens

<400> 6
Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210> 7
<211> 184
<212> PRT
<213> Mus musculus

<400> 7
Met Lys Thr Val Pro Ala Met Leu Gly Thr Pro Arg Leu Phe Arg Glu 
1               5                   10                  15      


Phe Phe Ile Leu His Leu Gly Leu Trp Ser Ile Leu Cys Glu Lys Ala 
            20                  25                  30          


Thr Lys Arg Asn Asp Glu Glu Cys Pro Val Gln Leu Thr Ile Thr Arg 
        35                  40                  45              


Asn Ser Lys Gln Ser Ala Arg Thr Gly Glu Leu Phe Lys Ile Gln Cys 
    50                  55                  60                  


Pro Val Lys Tyr Cys Val His Arg Pro Asn Val Thr Trp Cys Lys His 
65                  70                  75                  80  


Asn Gly Thr Ile Cys Val Pro Leu Glu Val Ser Pro Gln Leu Tyr Thr 
                85                  90                  95      


Ser Trp Glu Glu Asn Gln Ser Val Pro Val Phe Val Leu His Phe Lys 
            100                 105                 110         


Pro Ile His Leu Ser Asp Asn Gly Ser Tyr Ser Cys Ser Thr Asn Phe 
        115                 120                 125             


Asn Ser Gln Val Ile Asn Ser His Ser Val Thr Ile His Val Thr Glu 
    130                 135                 140                 


Arg Thr Gln Asn Ser Ser Glu His Pro Leu Ile Thr Val Ser Asp Ile 
145                 150                 155                 160 


Pro Asp Ala Thr Asn Ala Ser Gly Pro Ser Thr Met Glu Glu Arg Pro 
                165                 170                 175     


Gly Arg Thr Trp Leu Leu Tyr Thr 
            180                 


<210> 8
<211> 289
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210> 9
<211> 187
<212> PRT
<213> Mus musculus

<400> 9
Met Glu Arg Ile Leu Met Ala Pro Gly Gln Ser Cys Cys Ala Leu Ala 
1               5                   10                  15      


Ile Leu Leu Ala Ile Val Asn Phe Gln His Gly Gly Cys Ile His Val 
            20                  25                  30          


Thr Ser Ser Ala Ser Gln Lys Gly Gly Arg Leu Asp Leu Thr Cys Thr 
        35                  40                  45              


Leu Trp His Lys Lys Asp Glu Ala Glu Gly Leu Ile Leu Phe Trp Cys 
    50                  55                  60                  


Lys Asp Asn Pro Trp Asn Cys Ser Pro Glu Thr Asn Leu Glu Gln Leu 
65                  70                  75                  80  


Arg Val Lys Arg Asp Pro Glu Thr Asp Gly Ile Thr Glu Lys Ser Ser 
                85                  90                  95      


Gln Leu Val Phe Thr Ile Glu Gln Ala Thr Pro Ser Asp Ser Gly Thr 
            100                 105                 110         


Tyr Gln Cys Cys Ala Arg Ser Gln Lys Pro Glu Ile Tyr Ile His Gly 
        115                 120                 125             


His Phe Leu Ser Val Leu Val Thr Gly Asn His Thr Glu Ile Arg Gln 
    130                 135                 140                 


Arg Gln Arg Ser His Pro Asp Phe Ser His Ile Asn Gly Thr Leu Ser 
145                 150                 155                 160 


Ser Gly Phe Leu Gln Val Lys Ala Trp Gly Met Leu Val Thr Ser Leu 
                165                 170                 175     


Val Ala Leu Gln Ala Leu Tyr Thr Leu Ala Ala 
            180                 185         


<210> 10
<211> 181
<212> PRT
<213> Homo sapiens

<400> 10
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210> 11
<211> 255
<212> PRT
<213> Mus musculus

<400> 11
Met Ile Gly Gln Ala Val Leu Phe Thr Thr Phe Leu Leu Leu Arg Ala 
1               5                   10                  15      


His Gln Gly Gln Asp Cys Pro Asp Ser Ser Glu Glu Val Val Gly Val 
            20                  25                  30          


Ser Gly Lys Pro Val Gln Leu Arg Pro Ser Asn Ile Gln Thr Lys Asp 
        35                  40                  45              


Val Ser Val Gln Trp Lys Lys Thr Glu Gln Gly Ser His Arg Lys Ile 
    50                  55                  60                  


Glu Ile Leu Asn Trp Tyr Asn Asp Gly Pro Ser Trp Ser Asn Val Ser 
65                  70                  75                  80  


Phe Ser Asp Ile Tyr Gly Phe Asp Tyr Gly Asp Phe Ala Leu Ser Ile 
                85                  90                  95      


Lys Ser Ala Lys Leu Gln Asp Ser Gly His Tyr Leu Leu Glu Ile Thr 
            100                 105                 110         


Asn Thr Gly Gly Lys Val Cys Asn Lys Asn Phe Gln Leu Leu Ile Leu 
        115                 120                 125             


Asp His Val Glu Thr Pro Asn Leu Lys Ala Gln Trp Lys Pro Trp Thr 
    130                 135                 140                 


Asn Gly Thr Cys Gln Leu Phe Leu Ser Cys Leu Val Thr Lys Asp Asp 
145                 150                 155                 160 


Asn Val Ser Tyr Ala Leu Tyr Arg Gly Ser Thr Leu Ile Ser Asn Gln 
                165                 170                 175     


Arg Asn Ser Thr His Trp Glu Asn Gln Ile Asp Ala Ser Ser Leu His 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Ser Asn Arg Ala Ser Trp Ala Asn His Thr 
        195                 200                 205             


Leu Asn Phe Thr His Gly Cys Gln Ser Val Pro Ser Asn Phe Arg Phe 
    210                 215                 220                 


Leu Pro Phe Gly Val Ile Ile Val Ile Leu Val Thr Leu Phe Leu Gly 
225                 230                 235                 240 


Ala Ile Ile Cys Phe Cys Val Trp Thr Lys Lys Arg Lys Ala Ala 
                245                 250                 255 


<210> 12
<211> 365
<212> PRT
<213> Homo sapiens

<400> 12
Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Asp Lys 
        115                 120                 125             


Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu Asp Arg Gly 
    130                 135                 140                 


Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp Gly Asn Val 
145                 150                 155                 160 


Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Thr Ala Gly Asn 
                165                 170                 175     


Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Thr His Thr Tyr 
            180                 185                 190         


Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu Ser His Thr Leu Asn 
        195                 200                 205             


Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro 
    210                 215                 220                 


Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
225                 230                 235                 240 


Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu 
                245                 250                 255     


Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu 
            260                 265                 270         


Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly 
        275                 280                 285             


Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser 
    290                 295                 300                 


Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys 
305                 310                 315                 320 


Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile 
                325                 330                 335     


Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg 
            340                 345                 350         


Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
        355                 360                 365 


<210> 13
<211> 188
<212> PRT
<213> Mus musculus

<400> 13
Met Ala Asp Ser Ser Ile Tyr Ser Thr Leu Glu Leu Pro Glu Ala Pro 
1               5                   10                  15      


Gln Val Gln Asp Glu Ser Arg Trp Lys Leu Lys Ala Val Leu His Arg 
            20                  25                  30          


Pro His Leu Ser Arg Phe Ala Met Val Ala Leu Gly Leu Leu Thr Val 
        35                  40                  45              


Ile Leu Met Ser Leu Leu Met Tyr Gln Arg Ile Leu Cys Cys Gly Ser 
    50                  55                  60                  


Lys Asp Ser Thr Cys Ser His Cys Pro Ser Cys Pro Ile Leu Trp Thr 
65                  70                  75                  80  


Arg Asn Gly Ser His Cys Tyr Tyr Phe Ser Met Glu Lys Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Lys Phe Cys Ala Asp Lys Gly Ser His Leu Leu Thr 
            100                 105                 110         


Phe Pro Asp Asn Gln Gly Val Lys Leu Phe Gly Glu Tyr Leu Gly Gln 
        115                 120                 125             


Asp Phe Tyr Trp Ile Gly Leu Arg Asn Ile Asp Gly Trp Arg Trp Glu 
    130                 135                 140                 


Gly Gly Pro Ala Leu Ser Leu Arg Ile Leu Thr Asn Ser Leu Ile Gln 
145                 150                 155                 160 


Arg Cys Gly Ala Ile His Arg Asn Gly Leu Gln Ala Ser Ser Cys Glu 
                165                 170                 175     


Val Ala Leu Gln Trp Ile Cys Lys Lys Val Leu Tyr 
            180                 185             


<210> 14
<211> 195
<212> PRT
<213> Homo sapiens

<400> 14
Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu Val Ala Ile Ala Leu Gly Leu Leu Thr Ala 
        35                  40                  45              


Val Leu Leu Ser Val Leu Leu Tyr Gln Trp Ile Leu Cys Gln Gly Ser 
    50                  55                  60                  


Asn Tyr Ser Thr Cys Ala Ser Cys Pro Ser Cys Pro Asp Arg Trp Met 
65                  70                  75                  80  


Lys Tyr Gly Asn His Cys Tyr Tyr Phe Ser Val Glu Glu Lys Asp Trp 
                85                  90                  95      


Asn Ser Ser Leu Glu Phe Cys Leu Ala Arg Asp Ser His Leu Leu Val 
            100                 105                 110         


Ile Thr Asp Asn Gln Glu Met Ser Leu Leu Gln Val Phe Leu Ser Glu 
        115                 120                 125             


Ala Phe Cys Trp Ile Gly Leu Arg Asn Asn Ser Gly Trp Arg Trp Glu 
    130                 135                 140                 


Asp Gly Ser Pro Leu Asn Phe Ser Arg Ile Ser Ser Asn Ser Phe Val 
145                 150                 155                 160 


Gln Thr Cys Gly Ala Ile Asn Lys Asn Gly Leu Gln Ala Ser Ser Cys 
                165                 170                 175     


Glu Val Pro Leu His Trp Val Cys Lys Lys Cys Pro Phe Ala Asp Gln 
            180                 185                 190         


Ala Leu Phe 
        195 


<210> 15
<211> 333
<212> PRT
<213> Mus musculus

<400> 15
Met Ala Tyr Val Thr Trp Leu Leu Ala Ile Leu His Val His Lys Ala 
1               5                   10                  15      


Leu Cys Glu Glu Thr Leu Trp Asp Thr Thr Val Arg Leu Ser Glu Thr 
            20                  25                  30          


Met Thr Leu Glu Cys Val Tyr Pro Leu Thr His Asn Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Thr Lys Asn Thr Gly Thr Lys Thr Val Ser Ile Ala Val Tyr 
    50                  55                  60                  


Asn Pro Asn His Asn Met His Ile Glu Ser Asn Tyr Leu His Arg Val 
65                  70                  75                  80  


His Phe Leu Asn Ser Thr Val Gly Phe Arg Asn Met Ser Leu Ser Phe 
                85                  90                  95      


Tyr Asn Ala Ser Glu Ala Asp Ile Gly Ile Tyr Ser Cys Leu Phe His 
            100                 105                 110         


Ala Phe Pro Asn Gly Pro Trp Glu Lys Lys Ile Lys Val Val Trp Ser 
        115                 120                 125             


Asp Ser Phe Glu Ile Ala Ala Pro Ser Asp Ser Tyr Leu Ser Ala Glu 
    130                 135                 140                 


Pro Gly Gln Asp Val Thr Leu Thr Cys Gln Leu Pro Arg Thr Trp Pro 
145                 150                 155                 160 


Val Gln Gln Val Ile Trp Glu Lys Val Gln Pro His Gln Val Asp Ile 
                165                 170                 175     


Leu Ala Ser Cys Asn Leu Ser Gln Glu Thr Arg Tyr Thr Ser Lys Tyr 
            180                 185                 190         


Leu Arg Gln Thr Arg Ser Asn Cys Ser Gln Gly Ser Met Lys Ser Ile 
        195                 200                 205             


Leu Ile Ile Pro Asn Ala Met Ala Ala Asp Ser Gly Leu Tyr Arg Cys 
    210                 215                 220                 


Arg Ser Glu Ala Ile Thr Gly Lys Asn Lys Ser Phe Val Ile Arg Leu 
225                 230                 235                 240 


Ile Ile Thr Asp Gly Gly Thr Asn Lys His Phe Ile Leu Pro Ile Val 
                245                 250                 255     


Gly Gly Leu Val Ser Leu Leu Leu Val Ile Leu Ile Ile Ile Ile Phe 
            260                 265                 270         


Ile Leu Tyr Asn Arg Lys Arg Arg Arg Gln Val Arg Ile Pro Leu Lys 
        275                 280                 285             


Glu Pro Arg Asp Lys Gln Ser Lys Val Ala Thr Asn Cys Arg Ser Pro 
    290                 295                 300                 


Thr Ser Pro Ile Gln Ser Thr Asp Asp Glu Lys Glu Asp Ile Tyr Val 
305                 310                 315                 320 


Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Pro Arg Leu 
                325                 330             


<210> 16
<211> 336
<212> PRT
<213> Homo sapiens

<400> 16
Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210> 17
<211> 165
<212> PRT
<213> Mus musculus

<400> 17
Met Lys Gly Trp Leu Leu Leu Val Trp Val Gln Gly Leu Ile Gln Ala 
1               5                   10                  15      


Ala Phe Leu Ala Thr Gly Ala Thr Ala Gly Thr Ile Asp Thr Lys Arg 
            20                  25                  30          


Asn Ile Ser Ala Glu Glu Gly Gly Ser Val Ile Leu Gln Cys His Phe 
        35                  40                  45              


Ser Ser Asp Thr Ala Glu Val Thr Gln Val Asp Trp Lys Gln Gln Asp 
    50                  55                  60                  


Gln Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly Trp His Val Ala Ser 
65                  70                  75                  80  


Val Phe Ser Asp Arg Val Val Pro Gly Pro Ser Leu Gly Leu Thr Phe 
                85                  90                  95      


Gln Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr Phe Cys Thr Tyr His 
            100                 105                 110         


Thr Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile Phe Leu Lys Val Gln 
        115                 120                 125             


Glu Ser Ser Val Ala Gln Phe Gln Thr Ala Pro Leu Gly Gly Thr Met 
    130                 135                 140                 


Ala Ala Val Leu Gly Leu Ile Cys Leu Met Val Thr Gly Val Thr Val 
145                 150                 155                 160 


Leu Ala Arg Lys Lys 
                165 


<210> 18
<211> 244
<212> PRT
<213> Homo sapiens

<400> 18
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210> 19
<211> 316
<212> PRT
<213> Mus musculus

<400> 19
Met Leu Arg Gly Trp Gly Gly Pro Ser Val Gly Val Cys Val Arg Thr 
1               5                   10                  15      


Ala Leu Gly Val Leu Cys Leu Cys Leu Thr Gly Ala Val Glu Val Gln 
            20                  25                  30          


Val Ser Glu Asp Pro Val Val Ala Leu Val Asp Thr Asp Ala Thr Leu 
        35                  40                  45              


Arg Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr 
65                  70                  75                  80  


Glu Gly Arg Asp Gln Gly Ser Ala Tyr Ser Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Val Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Thr Asp Glu Gly Ser Tyr Thr Cys Phe Val Ser Ile Gln Asp 
        115                 120                 125             


Phe Asp Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asn Met 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Lys Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Arg Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Leu Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Val Val Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Asp Gly Glu Gly Ser Lys Thr Ala Leu Arg Pro Leu Lys Pro 
    290                 295                 300                 


Ser Glu Asn Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210> 20
<211> 534
<212> PRT
<213> Homo sapiens

<400> 20
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210> 21
<211> 308
<212> PRT
<213> Mus musculus

<400> 21
Met Gly Val Pro Ala Val Pro Glu Ala Ser Ser Pro Arg Trp Gly Thr 
1               5                   10                  15      


Leu Leu Leu Ala Ile Phe Leu Ala Ala Ser Arg Gly Leu Val Ala Ala 
            20                  25                  30          


Phe Lys Val Thr Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Ala Thr Leu Thr Cys Arg Ile Leu Gly Pro Val Ser Lys Gly His 
    50                  55                  60                  


Asp Val Thr Ile Tyr Lys Thr Trp Tyr Leu Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Met Cys Lys Glu His Arg Pro Ile Arg Asn Phe Thr Leu Gln His 
                85                  90                  95      


Leu Gln His His Gly Ser His Leu Lys Ala Asn Ala Ser His Asp Gln 
            100                 105                 110         


Pro Gln Lys His Gly Leu Glu Leu Ala Ser Asp His His Gly Asn Phe 
        115                 120                 125             


Ser Ile Thr Leu Arg Asn Val Thr Pro Arg Asp Ser Gly Leu Tyr Cys 
    130                 135                 140                 


Cys Leu Val Ile Glu Leu Lys Asn His His Pro Glu Gln Arg Phe Tyr 
145                 150                 155                 160 


Gly Ser Met Glu Leu Gln Val Gln Ala Gly Lys Gly Ser Gly Ser Thr 
                165                 170                 175     


Cys Met Ala Ser Asn Glu Gln Asp Ser Asp Ser Ile Thr Ala Ala Ala 
            180                 185                 190         


Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu Pro Leu Ile 
        195                 200                 205             


Leu Leu Leu Val Tyr Lys Gln Arg Gln Val Ala Ser His Arg Arg Ala 
    210                 215                 220                 


Gln Glu Leu Val Arg Met Asp Ser Asn Thr Gln Gly Ile Glu Asn Pro 
225                 230                 235                 240 


Gly Phe Glu Thr Thr Pro Pro Phe Gln Gly Met Pro Glu Ala Lys Thr 
                245                 250                 255     


Arg Pro Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser Glu Ser Gly 
            260                 265                 270         


Arg Tyr Leu Leu Ser Asp Pro Ser Thr Pro Leu Ser Pro Pro Gly Pro 
        275                 280                 285             


Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp Ser Pro Asn 
    290                 295                 300                 


Ser Glu Ala Ile 
305             


<210> 22
<211> 311
<212> PRT
<213> Homo sapiens

<400> 22
Met Gly Val Pro Thr Ala Leu Glu Ala Gly Ser Trp Arg Trp Gly Ser 
1               5                   10                  15      


Leu Leu Phe Ala Leu Phe Leu Ala Ala Ser Leu Gly Pro Val Ala Ala 
            20                  25                  30          


Phe Lys Val Ala Thr Pro Tyr Ser Leu Tyr Val Cys Pro Glu Gly Gln 
        35                  40                  45              


Asn Val Thr Leu Thr Cys Arg Leu Leu Gly Pro Val Asp Lys Gly His 
    50                  55                  60                  


Asp Val Thr Phe Tyr Lys Thr Trp Tyr Arg Ser Ser Arg Gly Glu Val 
65                  70                  75                  80  


Gln Thr Cys Ser Glu Arg Arg Pro Ile Arg Asn Leu Thr Phe Gln Asp 
                85                  90                  95      


Leu His Leu His His Gly Gly His Gln Ala Ala Asn Thr Ser His Asp 
            100                 105                 110         


Leu Ala Gln Arg His Gly Leu Glu Ser Ala Ser Asp His His Gly Asn 
        115                 120                 125             


Phe Ser Ile Thr Met Arg Asn Leu Thr Leu Leu Asp Ser Gly Leu Tyr 
    130                 135                 140                 


Cys Cys Leu Val Val Glu Ile Arg His His His Ser Glu His Arg Val 
145                 150                 155                 160 


His Gly Ala Met Glu Leu Gln Val Gln Thr Gly Lys Asp Ala Pro Ser 
                165                 170                 175     


Asn Cys Val Val Tyr Pro Ser Ser Ser Gln Asp Ser Glu Asn Ile Thr 
            180                 185                 190         


Ala Ala Ala Leu Ala Thr Gly Ala Cys Ile Val Gly Ile Leu Cys Leu 
        195                 200                 205             


Pro Leu Ile Leu Leu Leu Val Tyr Lys Gln Arg Gln Ala Ala Ser Asn 
    210                 215                 220                 


Arg Arg Ala Gln Glu Leu Val Arg Met Asp Ser Asn Ile Gln Gly Ile 
225                 230                 235                 240 


Glu Asn Pro Gly Phe Glu Ala Ser Pro Pro Ala Gln Gly Ile Pro Glu 
                245                 250                 255     


Ala Lys Val Arg His Pro Leu Ser Tyr Val Ala Gln Arg Gln Pro Ser 
            260                 265                 270         


Glu Ser Gly Arg His Leu Leu Ser Glu Pro Ser Thr Pro Leu Ser Pro 
        275                 280                 285             


Pro Gly Pro Gly Asp Val Phe Phe Pro Ser Leu Asp Pro Val Pro Asp 
    290                 295                 300                 


Ser Pro Asn Phe Glu Val Ile 
305                 310     


<210> 23
<211> 281
<212> PRT
<213> Mus musculus

<400> 23
Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ala Arg Ser Leu Glu Asn Ala Tyr Val Phe Glu Val Gly Lys 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Ser Thr Pro Gly Ala Leu 
        35                  40                  45              


Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr 
    50                  55                  60                  


Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser 
65                  70                  75                  80  


Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu 
                85                  90                  95      


Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg 
            100                 105                 110         


Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu 
        115                 120                 125             


Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp 
    130                 135                 140                 


Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile 
                165                 170                 175     


Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Thr 
            180                 185                 190         


Ala Ile His Ile Gly Val Gly Val Ser Ala Gly Leu Thr Leu Ala Leu 
        195                 200                 205             


Ile Ile Gly Val Leu Ile Leu Lys Trp Tyr Ser Cys Lys Lys Lys Lys 
    210                 215                 220                 


Leu Ser Ser Leu Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly 
225                 230                 235                 240 


Leu Ala Asn Ala Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr 
                245                 250                 255     


Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr 
            260                 265                 270         


Cys Tyr Val Asn Ser Gln Gln Pro Ser 
        275                 280     


<210> 24
<211> 301
<212> PRT
<213> Homo sapiens

<400> 24
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210> 25
<211> 290
<212> PRT
<213> Mus musculus

<400> 25
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Thr His Trp 
225                 230                 235                 240 


Val Leu Leu Gly Ser Ile Leu Leu Phe Leu Ile Val Val Ser Thr Val 
                245                 250                 255     


Leu Leu Phe Leu Arg Lys Gln Val Arg Met Leu Asp Val Glu Lys Cys 
            260                 265                 270         


Gly Val Glu Asp Thr Ser Ser Lys Asn Arg Asn Asp Thr Gln Phe Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 26
<211> 290
<212> PRT
<213> Homo sapiens

<400> 26
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 27
<211> 247
<212> PRT
<213> Mus musculus

<400> 27
Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Trp Pro Leu His 
    210                 215                 220                 


Val Phe Ile Pro Ala Cys Thr Ile Ala Leu Ile Phe Leu Ala Ile Val 
225                 230                 235                 240 


Ile Ile Gln Arg Lys Arg Ile 
                245         


<210> 28
<211> 273
<212> PRT
<213> Homo sapiens

<400> 28
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210> 29
<211> 276
<212> PRT
<213> Mus musculus

<400> 29
Met Glu Pro Leu Pro Gly Trp Gly Ser Ala Pro Trp Ser Gln Ala Pro 
1               5                   10                  15      


Thr Asp Asn Thr Phe Arg Leu Val Pro Cys Val Phe Leu Leu Asn Leu 
            20                  25                  30          


Leu Gln Arg Ile Ser Ala Gln Pro Ser Cys Arg Gln Glu Glu Phe Leu 
        35                  40                  45              


Val Gly Asp Glu Cys Cys Pro Met Cys Asn Pro Gly Tyr His Val Lys 
    50                  55                  60                  


Gln Val Cys Ser Glu His Thr Gly Thr Val Cys Ala Pro Cys Pro Pro 
65                  70                  75                  80  


Gln Thr Tyr Thr Ala His Ala Asn Gly Leu Ser Lys Cys Leu Pro Cys 
                85                  90                  95      


Gly Val Cys Asp Pro Asp Met Gly Leu Leu Thr Trp Gln Glu Cys Ser 
            100                 105                 110         


Ser Trp Lys Asp Thr Val Cys Arg Cys Ile Pro Gly Tyr Phe Cys Glu 
        115                 120                 125             


Asn Gln Asp Gly Ser His Cys Ser Thr Cys Leu Gln His Thr Thr Cys 
    130                 135                 140                 


Pro Pro Gly Gln Arg Val Glu Lys Arg Gly Thr His Asp Gln Asp Thr 
145                 150                 155                 160 


Val Cys Ala Asp Cys Leu Thr Gly Thr Phe Ser Leu Gly Gly Thr Gln 
                165                 170                 175     


Glu Glu Cys Leu Pro Trp Thr Asn Cys Ser Ala Phe Gln Gln Glu Val 
            180                 185                 190         


Arg Arg Gly Thr Asn Ser Thr Asp Thr Thr Cys Ser Ser Gln Val Val 
        195                 200                 205             


Tyr Tyr Val Val Ser Ile Leu Leu Pro Leu Val Ile Val Gly Val Gly 
    210                 215                 220                 


Ile Ala Gly Phe Leu Ile Cys Thr Arg Arg His Leu His Thr Ser Ser 
225                 230                 235                 240 


Val Ala Lys Glu Leu Glu Pro Phe Gln Gln Glu Gln Gln Glu Asn Thr 
                245                 250                 255     


Ile Arg Phe Pro Val Thr Glu Val Gly Phe Ala Glu Thr Glu Glu Glu 
            260                 265                 270         


Thr Ala Ser Asn 
        275     


<210> 30
<211> 283
<212> PRT
<213> Homo sapiens

<400> 30
Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210> 31
<211> 240
<212> PRT
<213> Mus musculus

<400> 31
Met Cys Phe Ile Lys Gln Gly Trp Cys Leu Val Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Gly Thr Gly Phe Gln Gly His Ser Ile Pro Asp Ile Asn 
            20                  25                  30          


Ala Thr Thr Gly Ser Asn Val Thr Leu Lys Ile His Lys Asp Pro Leu 
        35                  40                  45              


Gly Pro Tyr Lys Arg Ile Thr Trp Leu His Thr Lys Asn Gln Lys Ile 
    50                  55                  60                  


Leu Glu Tyr Asn Tyr Asn Ser Thr Lys Thr Ile Phe Glu Ser Glu Phe 
65                  70                  75                  80  


Lys Gly Arg Val Tyr Leu Glu Glu Asn Asn Gly Ala Leu His Ile Ser 
                85                  90                  95      


Asn Val Arg Lys Glu Asp Lys Gly Thr Tyr Tyr Met Arg Val Leu Arg 
            100                 105                 110         


Glu Thr Glu Asn Glu Leu Lys Ile Thr Leu Glu Val Phe Asp Pro Val 
        115                 120                 125             


Pro Lys Pro Ser Ile Glu Ile Asn Lys Thr Glu Ala Ser Thr Asp Ser 
    130                 135                 140                 


Cys His Leu Arg Leu Ser Cys Glu Val Lys Asp Gln His Val Asp Tyr 
145                 150                 155                 160 


Thr Trp Tyr Glu Ser Ser Gly Pro Phe Pro Lys Lys Ser Pro Gly Tyr 
                165                 170                 175     


Val Leu Asp Leu Ile Val Thr Pro Gln Asn Lys Ser Thr Phe Tyr Thr 
            180                 185                 190         


Cys Gln Val Ser Asn Pro Val Ser Ser Lys Asn Asp Thr Val Tyr Phe 
        195                 200                 205             


Thr Leu Pro Cys Asp Leu Ala Arg Ser Ser Gly Val Cys Trp Thr Ala 
    210                 215                 220                 


Thr Trp Leu Val Val Thr Thr Leu Ile Ile His Arg Ile Leu Leu Thr 
225                 230                 235                 240 


<210> 32
<211> 243
<212> PRT
<213> Homo sapiens

<400> 32
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210> 33
<211> 530
<212> PRT
<213> Mus musculus

<400> 33
Met Ala Arg Ala Ala Val Leu Pro Pro Ser Arg Leu Ser Pro Thr Leu 
1               5                   10                  15      


Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gln Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Arg Val Leu Pro Glu Val Arg Gly Arg Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Thr Thr Glu Arg Val 
    50                  55                  60                  


Ser Gln Val Thr Trp Gln Arg Leu Asp Gly Thr Val Val Ala Ala Phe 
65                  70                  75                  80  


His Pro Ser Phe Gly Val Asp Phe Pro Asn Ser Gln Phe Ser Lys Asp 
                85                  90                  95      


Arg Leu Ser Phe Val Arg Ala Arg Pro Glu Thr Asn Ala Asp Leu Arg 
            100                 105                 110         


Asp Ala Thr Leu Ala Phe Arg Gly Leu Arg Val Glu Asp Glu Gly Asn 
        115                 120                 125             


Tyr Thr Cys Glu Phe Ala Thr Phe Pro Asn Gly Thr Arg Arg Gly Val 
    130                 135                 140                 


Thr Trp Leu Arg Val Ile Ala Gln Pro Glu Asn His Ala Glu Ala Gln 
145                 150                 155                 160 


Glu Val Thr Ile Gly Pro Gln Ser Val Ala Val Ala Arg Cys Val Ser 
                165                 170                 175     


Thr Gly Gly Arg Pro Pro Ala Arg Ile Thr Trp Ile Ser Ser Leu Gly 
            180                 185                 190         


Gly Glu Ala Lys Asp Thr Gln Glu Pro Gly Ile Gln Ala Gly Thr Val 
        195                 200                 205             


Thr Ile Ile Ser Arg Tyr Ser Leu Val Pro Val Gly Arg Ala Asp Gly 
    210                 215                 220                 


Val Lys Val Thr Cys Arg Val Glu His Glu Ser Phe Glu Glu Pro Ile 
225                 230                 235                 240 


Leu Leu Pro Val Thr Leu Ser Val Arg Tyr Pro Pro Glu Val Ser Ile 
                245                 250                 255     


Ser Gly Tyr Asp Asp Asn Trp Tyr Leu Gly Arg Ser Glu Ala Ile Leu 
            260                 265                 270         


Thr Cys Asp Val Arg Ser Asn Pro Glu Pro Thr Asp Tyr Asp Trp Ser 
        275                 280                 285             


Thr Thr Ser Gly Val Phe Pro Ala Ser Ala Val Ala Gln Gly Ser Gln 
    290                 295                 300                 


Leu Leu Val His Ser Val Asp Arg Met Val Asn Thr Thr Phe Ile Cys 
305                 310                 315                 320 


Thr Ala Thr Asn Ala Val Gly Thr Gly Arg Ala Glu Gln Val Ile Leu 
                325                 330                 335     


Val Arg Glu Ser Pro Ser Thr Ala Gly Ala Gly Ala Thr Gly Gly Ile 
            340                 345                 350         


Ile Gly Gly Ile Ile Ala Ala Ile Ile Ala Thr Ala Val Ala Gly Thr 
        355                 360                 365             


Gly Ile Leu Ile Cys Arg Gln Gln Arg Lys Glu Gln Arg Leu Gln Ala 
    370                 375                 380                 


Ala Asp Glu Glu Glu Glu Leu Glu Gly Pro Pro Ser Tyr Lys Pro Pro 
385                 390                 395                 400 


Thr Pro Lys Ala Lys Leu Glu Glu Pro Glu Met Pro Ser Gln Leu Phe 
                405                 410                 415     


Thr Leu Gly Ala Ser Glu His Ser Pro Val Lys Thr Pro Tyr Phe Asp 
            420                 425                 430         


Ala Gly Val Ser Cys Ala Asp Gln Glu Met Pro Arg Tyr His Glu Leu 
        435                 440                 445             


Pro Thr Leu Glu Glu Arg Ser Gly Pro Leu Leu Leu Gly Ala Thr Gly 
    450                 455                 460                 


Leu Gly Pro Ser Leu Leu Val Pro Pro Gly Pro Asn Val Val Glu Gly 
465                 470                 475                 480 


Val Ser Leu Ser Leu Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Asp 
                485                 490                 495     


Phe Leu Asp Lys Ile Asn Pro Ile Tyr Asp Ala Leu Ser Tyr Pro Ser 
            500                 505                 510         


Pro Ser Asp Ser Tyr Gln Ser Lys Asp Phe Phe Val Ser Arg Ala Met 
        515                 520                 525             


Tyr Val 
    530 


<210> 34
<211> 538
<212> PRT
<213> Homo sapiens

<400> 34
Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210> 35
<211> 408
<212> PRT
<213> Mus musculus

<400> 35
Met Ala Gln Leu Ala Arg Ala Thr Arg Ser Pro Leu Ser Trp Leu Leu 
1               5                   10                  15      


Leu Leu Phe Cys Tyr Ala Leu Arg Lys Ala Gly Gly Asp Ile Arg Val 
            20                  25                  30          


Leu Val Pro Tyr Asn Ser Thr Gly Val Leu Gly Gly Ser Thr Thr Leu 
        35                  40                  45              


His Cys Ser Leu Thr Ser Asn Glu Asn Val Thr Ile Thr Gln Ile Thr 
    50                  55                  60                  


Trp Met Lys Lys Asp Ser Gly Gly Ser His Ala Leu Val Ala Val Phe 
65                  70                  75                  80  


His Pro Lys Lys Gly Pro Asn Ile Lys Glu Pro Glu Arg Val Lys Phe 
                85                  90                  95      


Leu Ala Ala Gln Gln Asp Leu Arg Asn Ala Ser Leu Ala Ile Ser Asn 
            100                 105                 110         


Leu Ser Val Glu Asp Glu Gly Ile Tyr Glu Cys Gln Ile Ala Thr Phe 
        115                 120                 125             


Pro Arg Gly Ser Arg Ser Thr Asn Ala Trp Leu Lys Val Gln Ala Arg 
    130                 135                 140                 


Pro Lys Asn Thr Ala Glu Ala Leu Glu Pro Ser Pro Thr Leu Ile Leu 
145                 150                 155                 160 


Gln Asp Val Ala Lys Cys Ile Ser Ala Asn Gly His Pro Pro Gly Arg 
                165                 170                 175     


Ile Ser Trp Pro Ser Asn Val Asn Gly Ser His Arg Glu Met Lys Glu 
            180                 185                 190         


Pro Gly Ser Gln Pro Gly Thr Thr Thr Val Thr Ser Tyr Leu Ser Met 
        195                 200                 205             


Val Pro Ser Arg Gln Ala Asp Gly Lys Asn Ile Thr Cys Thr Val Glu 
    210                 215                 220                 


His Glu Ser Leu Gln Glu Leu Asp Gln Leu Leu Val Thr Leu Ser Gln 
225                 230                 235                 240 


Pro Tyr Pro Pro Glu Asn Val Ser Ile Ser Gly Tyr Asp Gly Asn Trp 
                245                 250                 255     


Tyr Val Gly Leu Thr Asn Leu Thr Leu Thr Cys Glu Ala His Ser Lys 
            260                 265                 270         


Pro Ala Pro Asp Met Ala Gly Tyr Asn Trp Ser Thr Thr Thr Gly Asp 
        275                 280                 285             


Phe Pro Asn Ser Val Lys Arg Gln Gly Asn Met Leu Leu Ile Ser Thr 
    290                 295                 300                 


Val Glu Asp Gly Leu Asn Asn Thr Val Ile Val Cys Glu Val Thr Asn 
305                 310                 315                 320 


Ala Leu Gly Ser Gly Gln Gly Gln Val His Ile Ile Val Lys Glu Lys 
                325                 330                 335     


Pro Glu Asn Met Gln Gln Asn Thr Arg Leu His Leu Gly Tyr Ile Phe 
            340                 345                 350         


Leu Ile Val Phe Val Leu Ala Val Val Ile Ile Ile Ala Ala Leu Tyr 
        355                 360                 365             


Thr Ile Arg Arg Cys Arg His Gly Arg Ala Leu Gln Ser Asn Pro Ser 
    370                 375                 380                 


Glu Arg Glu Asn Val Gln Tyr Ser Ser Val Asn Gly Asp Cys Arg Leu 
385                 390                 395                 400 


Asn Met Glu Pro Asn Ser Thr Arg 
                405             


<210> 36
<211> 417
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210> 37
<211> 521
<212> PRT
<213> Mus musculus

<400> 37
Met Glu Leu Ala Ser Ala His Leu His Lys Gly Gln Val Pro Trp Gly 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Ala Ser Trp Ser Pro Ala Thr 
            20                  25                  30          


Thr Ala Glu Val Thr Ile Glu Ala Val Pro Pro Gln Val Ala Glu Asp 
        35                  40                  45              


Asn Asn Val Leu Leu Leu Val His Asn Leu Pro Leu Ala Leu Gly Ala 
    50                  55                  60                  


Phe Ala Trp Tyr Lys Gly Asn Thr Thr Ala Ile Asp Lys Glu Ile Ala 
65                  70                  75                  80  


Arg Phe Val Pro Asn Ser Asn Met Asn Phe Thr Gly Gln Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Ser Asn Gly Ser Leu Leu Phe Gln Met Ile 
            100                 105                 110         


Thr Met Lys Asp Met Gly Val Tyr Thr Leu Asp Met Thr Asp Glu Asn 
        115                 120                 125             


Tyr Arg Arg Thr Gln Ala Thr Val Arg Phe His Val His Pro Ile Leu 
    130                 135                 140                 


Leu Lys Pro Asn Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Gly Asp 
145                 150                 155                 160 


Asp Ser Val Ser Leu Thr Cys Asp Ser Tyr Thr Asp Pro Asp Asn Ile 
                165                 170                 175     


Asn Tyr Leu Trp Ser Arg Asn Gly Glu Ser Leu Ser Glu Gly Asp Arg 
            180                 185                 190         


Leu Lys Leu Ser Glu Gly Asn Arg Thr Leu Thr Leu Leu Asn Val Thr 
        195                 200                 205             


Arg Asn Asp Thr Gly Pro Tyr Val Cys Glu Thr Arg Asn Pro Val Ser 
    210                 215                 220                 


Val Asn Arg Ser Asp Pro Phe Ser Leu Asn Ile Ile Tyr Gly Pro Asp 
225                 230                 235                 240 


Thr Pro Ile Ile Ser Pro Ser Asp Ile Tyr Leu His Pro Gly Ser Asn 
                245                 250                 255     


Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Phe 
            260                 265                 270         


Trp Leu Ile Asn Glu Lys Pro His Ala Ser Ser Gln Glu Leu Phe Ile 
        275                 280                 285             


Pro Asn Ile Thr Thr Asn Asn Ser Gly Thr Tyr Thr Cys Phe Val Asn 
    290                 295                 300                 


Asn Ser Val Thr Gly Leu Ser Arg Thr Thr Val Lys Asn Ile Thr Val 
305                 310                 315                 320 


Leu Glu Pro Val Thr Gln Pro Phe Leu Gln Val Thr Asn Thr Thr Val 
                325                 330                 335     


Lys Glu Leu Asp Ser Val Thr Leu Thr Cys Leu Ser Asn Asp Ile Gly 
            340                 345                 350         


Ala Asn Ile Gln Trp Leu Phe Asn Ser Gln Ser Leu Gln Leu Thr Glu 
        355                 360                 365             


Arg Met Thr Leu Ser Gln Asn Asn Ser Ile Leu Arg Ile Asp Pro Ile 
    370                 375                 380                 


Lys Arg Glu Asp Ala Gly Glu Tyr Gln Cys Glu Ile Ser Asn Pro Val 
385                 390                 395                 400 


Ser Val Arg Arg Ser Asn Ser Ile Lys Leu Asp Ile Ile Phe Asp Pro 
                405                 410                 415     


Thr Gln Gly Gly Leu Ser Asp Gly Ala Ile Ala Gly Ile Val Ile Gly 
            420                 425                 430         


Val Val Ala Gly Val Ala Leu Ile Ala Gly Leu Ala Tyr Phe Leu Tyr 
        435                 440                 445             


Ser Arg Lys Ser Gly Gly Gly Ser Asp Gln Arg Asp Leu Thr Glu His 
    450                 455                 460                 


Lys Pro Ser Thr Ser Asn His Asn Leu Ala Pro Ser Asp Asn Ser Pro 
465                 470                 475                 480 


Asn Lys Val Asp Asp Val Ala Tyr Thr Val Leu Asn Phe Asn Ser Gln 
                485                 490                 495     


Gln Pro Asn Arg Pro Thr Ser Ala Pro Ser Ser Pro Arg Ala Thr Glu 
            500                 505                 510         


Thr Val Tyr Ser Glu Val Lys Lys Lys 
        515                 520     


<210> 38
<211> 526
<212> PRT
<213> Homo sapiens

<400> 38
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210> 39
<211> 264
<212> PRT
<213> Mus musculus

<400> 39
Met Ala Asp Ser Phe Ser Leu Asn Asp Ala Leu Ala Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Tyr Pro Gly Ala Trp Gly Asn Gln Pro Gly Ala 
            20                  25                  30          


Gly Gly Tyr Pro Gly Ala Ala Tyr Pro Gly Ala Tyr Pro Gly Gln Ala 
        35                  40                  45              


Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly 
    50                  55                  60                  


Gln Ala Pro Pro Ser Ala Tyr Pro Gly Pro Thr Ala Pro Gly Ala Tyr 
65                  70                  75                  80  


Pro Gly Pro Thr Ala Pro Gly Ala Tyr Pro Gly Gln Pro Ala Pro Gly 
                85                  90                  95      


Ala Phe Pro Gly Gln Pro Gly Ala Pro Gly Ala Tyr Pro Gln Cys Ser 
            100                 105                 110         


Gly Gly Tyr Pro Ala Ala Gly Pro Tyr Gly Val Pro Ala Gly Pro Leu 
        115                 120                 125             


Thr Val Pro Tyr Asp Leu Pro Leu Pro Gly Gly Val Met Pro Arg Met 
    130                 135                 140                 


Leu Ile Thr Ile Met Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Val 
145                 150                 155                 160 


Leu Asp Phe Arg Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg 
                165                 170                 175     


Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Gln Asp 
            180                 185                 190         


Asn Asn Trp Gly Lys Glu Glu Arg Gln Ser Ala Phe Pro Phe Glu Ser 
        195                 200                 205             


Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Ala Asp His Phe Lys 
    210                 215                 220                 


Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Met Lys 
225                 230                 235                 240 


Asn Leu Arg Glu Ile Ser Gln Leu Gly Ile Ser Gly Asp Ile Thr Leu 
                245                 250                 255     


Thr Ser Ala Asn His Ala Met Ile 
            260                 


<210> 40
<211> 250
<212> PRT
<213> Homo sapiens

<400> 40
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210> 41
<211> 314
<212> PRT
<213> Mus musculus

<400> 41
Met Gly Lys Ile Tyr Ser Phe Val Leu Val Ala Ile Ala Leu Met Met 
1               5                   10                  15      


Gly Arg Glu Gly Trp Ala Leu Glu Ser Glu Ser Cys Leu Arg Glu Gln 
            20                  25                  30          


Val Arg Leu Arg Ala Gln Val His Gln Leu Glu Thr Arg Val Lys Gln 
        35                  40                  45              


Gln Gln Thr Met Ile Ala Gln Leu Leu His Glu Lys Glu Val Gln Phe 
    50                  55                  60                  


Leu Asp Lys Gly Ser Glu Asn Ser Phe Ile Asp Leu Gly Gly Lys Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Cys Ser Glu Ile Tyr Asn Asp Gly Phe Lys Gln Ser 
                85                  90                  95      


Gly Phe Tyr Lys Ile Lys Pro Leu Gln Ser Leu Ala Glu Phe Ser Val 
            100                 105                 110         


Tyr Cys Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg 
        115                 120                 125             


Ser Asp Gly Ser Glu Asn Phe Asn Arg Gly Trp Asn Asp Tyr Glu Asn 
    130                 135                 140                 


Gly Phe Gly Asn Phe Val Gln Asn Asn Gly Glu Tyr Trp Leu Gly Asn 
145                 150                 155                 160 


Lys Asn Ile Asn Leu Leu Thr Ile Gln Gly Asp Tyr Thr Leu Lys Ile 
                165                 170                 175     


Asp Leu Thr Asp Phe Glu Lys Asn Ser Ser Phe Ala Gln Tyr Gln Ser 
            180                 185                 190         


Phe Lys Val Gly Asp Lys Lys Ser Phe Tyr Glu Leu Asn Ile Gly Glu 
        195                 200                 205             


Tyr Ser Gly Thr Ala Gly Asp Ser Leu Ser Gly Thr Phe His Pro Glu 
    210                 215                 220                 


Val Gln Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp 
225                 230                 235                 240 


Arg Asp Asn Asp Asn Tyr Gln Gly Asn Cys Ala Glu Glu Glu Gln Ser 
                245                 250                 255     


Gly Trp Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr 
            260                 265                 270         


Tyr Arg Gly Ser Tyr Arg Ala Glu Thr Asp Asn Gly Val Val Trp Tyr 
        275                 280                 285             


Thr Trp His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile 
    290                 295                 300                 


Arg Pro Ser Asp Phe Ile Pro Asn Ile Ile 
305                 310                 


<210> 42
<211> 312
<212> PRT
<213> Homo sapiens

<400> 42
Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210> 43
<211> 288
<212> PRT
<213> Homo sapiens

<400> 43
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210> 44
<211> 306
<212> PRT
<213> Mus musculus

<400> 44
Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly 
                245                 250                 255     


Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys 
            260                 265                 270         


Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn 
        275                 280                 285             


Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val 
    290                 295                 300                 


Phe Leu 
305     


<210> 45
<211> 323
<212> PRT
<213> Homo sapiens

<400> 45
Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val 
                245                 250                 255     


Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn 
            260                 265                 270         


Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln 
        275                 280                 285             


Thr Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala 
    290                 295                 300                 


Gln Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp 
305                 310                 315                 320 


Thr Cys Phe 
            


<210> 46
<211> 309
<212> PRT
<213> Mus musculus

<400> 46
Met Asp Pro Arg Cys Thr Met Gly Leu Ala Ile Leu Ile Phe Val Thr 
1               5                   10                  15      


Val Leu Leu Ile Ser Asp Ala Val Ser Val Glu Thr Gln Ala Tyr Phe 
            20                  25                  30          


Asn Gly Thr Ala Tyr Leu Pro Cys Pro Phe Thr Lys Ala Gln Asn Ile 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Gln Lys Leu Val 
    50                  55                  60                  


Leu Tyr Glu His Tyr Leu Gly Thr Glu Lys Leu Asp Ser Val Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Gly Arg Thr Ser Phe Asp Arg Asn Asn Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Val Gln Ile Lys Asp Met Gly Ser Tyr Asp Cys Phe Ile 
            100                 105                 110         


Gln Lys Lys Pro Pro Thr Gly Ser Ile Ile Leu Gln Gln Thr Leu Thr 
        115                 120                 125             


Glu Leu Ser Val Ile Ala Asn Phe Ser Glu Pro Glu Ile Lys Leu Ala 
    130                 135                 140                 


Gln Asn Val Thr Gly Asn Ser Gly Ile Asn Leu Thr Cys Thr Ser Lys 
145                 150                 155                 160 


Gln Gly His Pro Lys Pro Lys Lys Met Tyr Phe Leu Ile Thr Asn Ser 
                165                 170                 175     


Thr Asn Glu Tyr Gly Asp Asn Met Gln Ile Ser Gln Asp Asn Val Thr 
            180                 185                 190         


Glu Leu Phe Ser Ile Ser Asn Ser Leu Ser Leu Ser Phe Pro Asp Gly 
        195                 200                 205             


Val Trp His Met Thr Val Val Cys Val Leu Glu Thr Glu Ser Met Lys 
    210                 215                 220                 


Ile Ser Ser Lys Pro Leu Asn Phe Thr Gln Glu Phe Pro Ser Pro Gln 
225                 230                 235                 240 


Thr Tyr Trp Lys Glu Ile Thr Ala Ser Val Thr Val Ala Leu Leu Leu 
                245                 250                 255     


Val Met Leu Leu Ile Ile Val Cys His Lys Lys Pro Asn Gln Pro Ser 
            260                 265                 270         


Arg Pro Ser Asn Thr Ala Ser Lys Leu Glu Arg Asp Ser Asn Ala Asp 
        275                 280                 285             


Arg Glu Thr Ile Asn Leu Lys Glu Leu Glu Pro Gln Ile Ala Ser Ala 
    290                 295                 300                 


Lys Pro Asn Ala Glu 
305                 


<210> 47
<211> 254
<212> PRT
<213> Homo sapiens

<400> 47
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210> 48
<211> 309
<212> PRT
<213> Mus musculus

<400> 48
Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210> 49
<211> 255
<212> PRT
<213> Homo sapiens

<400> 49
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210> 50
<211> 256
<212> PRT
<213> Mus musculus

<400> 50
Met Gly Asn Asn Cys Tyr Asn Val Val Val Ile Val Leu Leu Leu Val 
1               5                   10                  15      


Gly Cys Glu Lys Val Gly Ala Val Gln Asn Ser Cys Asp Asn Cys Gln 
            20                  25                  30          


Pro Gly Thr Phe Cys Arg Lys Tyr Asn Pro Val Cys Lys Ser Cys Pro 
        35                  40                  45              


Pro Ser Thr Phe Ser Ser Ile Gly Gly Gln Pro Asn Cys Asn Ile Cys 
    50                  55                  60                  


Arg Val Cys Ala Gly Tyr Phe Arg Phe Lys Lys Phe Cys Ser Ser Thr 
65                  70                  75                  80  


His Asn Ala Glu Cys Glu Cys Ile Glu Gly Phe His Cys Leu Gly Pro 
                85                  90                  95      


Gln Cys Thr Arg Cys Glu Lys Asp Cys Arg Pro Gly Gln Glu Leu Thr 
            100                 105                 110         


Lys Gln Gly Cys Lys Thr Cys Ser Leu Gly Thr Phe Asn Asp Gln Asn 
        115                 120                 125             


Gly Thr Gly Val Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Arg 
    130                 135                 140                 


Ser Val Leu Lys Thr Gly Thr Thr Glu Lys Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Pro Val Val Ser Phe Ser Pro Ser Thr Thr Ile Ser Val Thr Pro Glu 
                165                 170                 175     


Gly Gly Pro Gly Gly His Ser Leu Gln Val Leu Thr Leu Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Leu Leu Leu Ala Leu Ile Phe Ile Thr Leu Leu Phe 
        195                 200                 205             


Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
225                 230                 235                 240 


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
                245                 250                 255     


<210> 51
<211> 277
<212> PRT
<213> Homo sapiens

<400> 51
Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210> 52
<211> 272
<212> PRT
<213> Mus musculus

<400> 52
Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Phe Ala Val Leu Leu Gly Leu Gly Leu Gly Leu Leu 
    210                 215                 220                 


Ala Pro Leu Thr Val Leu Leu Ala Leu Tyr Leu Leu Arg Lys Ala Trp 
225                 230                 235                 240 


Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn Ser Phe Arg Thr 
                245                 250                 255     


Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


<210> 53
<211> 133
<212> PRT
<213> Homo sapiens

<400> 53
Met Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210> 54
<211> 198
<212> PRT
<213> Mus musculus

<400> 54
Met Glu Gly Glu Gly Val Gln Pro Leu Asp Glu Asn Leu Glu Asn Gly 
1               5                   10                  15      


Ser Arg Pro Arg Phe Lys Trp Lys Lys Thr Leu Arg Leu Val Val Ser 
            20                  25                  30          


Gly Ile Lys Gly Ala Gly Met Leu Leu Cys Phe Ile Tyr Val Cys Leu 
        35                  40                  45              


Gln Leu Ser Ser Ser Pro Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg 
    50                  55                  60                  


Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu Phe Ile Ser Ser Tyr 
65                  70                  75                  80  


Lys Asn Glu Tyr Gln Thr Met Glu Val Gln Asn Asn Ser Val Val Ile 
                85                  90                  95      


Lys Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln 
            100                 105                 110         


Glu Val Lys Ile Asp Leu His Phe Arg Glu Asp His Asn Pro Ile Ser 
        115                 120                 125             


Ile Pro Met Leu Asn Asp Gly Arg Arg Ile Val Phe Thr Val Val Ala 
    130                 135                 140                 


Ser Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr Val Asn Ala Pro Asp 
145                 150                 155                 160 


Thr Leu Cys Glu His Leu Gln Ile Asn Asp Gly Glu Leu Ile Val Val 
                165                 170                 175     


Gln Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly Ser Tyr His Ser Thr 
            180                 185                 190         


Val Asn Gln Val Pro Leu 
        195             


<210> 55
<211> 277
<212> PRT
<213> Homo sapiens

<400> 55
Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210> 56
<211> 289
<212> PRT
<213> Mus musculus

<400> 56
Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu Gly Gln Cys Val Thr Cys Ser Asp Lys Gln Tyr Leu 
            20                  25                  30          


His Asp Gly Gln Cys Cys Asp Leu Cys Gln Pro Gly Ser Arg Leu Thr 
        35                  40                  45              


Ser His Cys Thr Ala Leu Glu Lys Thr Gln Cys His Pro Cys Asp Ser 
    50                  55                  60                  


Gly Glu Phe Ser Ala Gln Trp Asn Arg Glu Ile Arg Cys His Gln His 
65                  70                  75                  80  


Arg His Cys Glu Pro Asn Gln Gly Leu Arg Val Lys Lys Glu Gly Thr 
                85                  90                  95      


Ala Glu Ser Asp Thr Val Cys Thr Cys Lys Glu Gly Gln His Cys Thr 
            100                 105                 110         


Ser Lys Asp Cys Glu Ala Cys Ala Gln His Thr Pro Cys Ile Pro Gly 
        115                 120                 125             


Phe Gly Val Met Glu Met Ala Thr Glu Thr Thr Asp Thr Val Cys His 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Gln Ser Ser Leu Phe Glu Lys 
145                 150                 155                 160 


Cys Tyr Pro Trp Thr Ser Cys Glu Asp Lys Asn Leu Glu Val Leu Gln 
                165                 170                 175     


Lys Gly Thr Ser Gln Thr Asn Val Ile Cys Gly Leu Lys Ser Arg Met 
            180                 185                 190         


Arg Ala Leu Leu Val Ile Pro Val Val Met Gly Ile Leu Ile Thr Ile 
        195                 200                 205             


Phe Gly Val Phe Leu Tyr Ile Lys Lys Val Val Lys Lys Pro Lys Asp 
    210                 215                 220                 


Asn Glu Ile Leu Pro Pro Ala Ala Arg Arg Gln Asp Pro Gln Glu Met 
225                 230                 235                 240 


Glu Asp Tyr Pro Gly His Asn Thr Ala Ala Pro Val Gln Glu Thr Leu 
                245                 250                 255     


His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile 
            260                 265                 270         


Ser Val Gln Glu Arg Gln Val Thr Asp Ser Ile Ala Leu Arg Pro Leu 
        275                 280                 285             


Val 
    


<210> 57
<211> 261
<212> PRT
<213> Homo sapiens

<400> 57
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 58
<211> 260
<212> PRT
<213> Mus musculus

<400> 58
Met Ile Glu Thr Tyr Ser Gln Pro Ser Pro Arg Ser Val Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ala Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Val Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Val Glu Glu Glu Val Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys Gly Glu Gly Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Met Arg Arg Gln Phe Glu Asp Leu Val Lys 
                85                  90                  95      


Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys Glu Asn Ser Phe Glu Met 
            100                 105                 110         


Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val Val Ser Glu 
        115                 120                 125             


Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys Lys Gly Tyr 
    130                 135                 140                 


Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly Lys Gln Leu 
145                 150                 155                 160 


Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln Val Thr Phe 
                165                 170                 175     


Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile Val Gly Leu 
            180                 185                 190         


Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu Lys Ala Ala 
        195                 200                 205             


Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser Val His Leu 
    210                 215                 220                 


Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe Val Asn Val 
225                 230                 235                 240 


Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser Ser Phe Gly 
                245                 250                 255     


Leu Leu Lys Leu 
            260 


<210> 59
<211> 302
<212> PRT
<213> Homo sapiens

<400> 59
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210> 60
<211> 322
<212> PRT
<213> Mus musculus

<400> 60
Met Gln Leu Lys Cys Pro Cys Phe Val Ser Leu Gly Thr Arg Gln Pro 
1               5                   10                  15      


Val Trp Lys Lys Leu His Val Ser Ser Gly Phe Phe Ser Gly Leu Gly 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Ser Ser Leu Cys Ala Ala Ser Ala Glu Thr 
        35                  40                  45              


Glu Val Gly Ala Met Val Gly Ser Asn Val Val Leu Ser Cys Ile Asp 
    50                  55                  60                  


Pro His Arg Arg His Phe Asn Leu Ser Gly Leu Tyr Val Tyr Trp Gln 
65                  70                  75                  80  


Ile Glu Asn Pro Glu Val Ser Val Thr Tyr Tyr Leu Pro Tyr Lys Ser 
                85                  90                  95      


Pro Gly Ile Asn Val Asp Ser Ser Tyr Lys Asn Arg Gly His Leu Ser 
            100                 105                 110         


Leu Asp Ser Met Lys Gln Gly Asn Phe Ser Leu Tyr Leu Lys Asn Val 
        115                 120                 125             


Thr Pro Gln Asp Thr Gln Glu Phe Thr Cys Arg Val Phe Met Asn Thr 
    130                 135                 140                 


Ala Thr Glu Leu Val Lys Ile Leu Glu Glu Val Val Arg Leu Arg Val 
145                 150                 155                 160 


Ala Ala Asn Phe Ser Thr Pro Val Ile Ser Thr Ser Asp Ser Ser Asn 
                165                 170                 175     


Pro Gly Gln Glu Arg Thr Tyr Thr Cys Met Ser Lys Asn Gly Tyr Pro 
            180                 185                 190         


Glu Pro Asn Leu Tyr Trp Ile Asn Thr Thr Asp Asn Ser Leu Ile Asp 
        195                 200                 205             


Thr Ala Leu Gln Asn Asn Thr Val Tyr Leu Asn Lys Leu Gly Leu Tyr 
    210                 215                 220                 


Asp Val Ile Ser Thr Leu Arg Leu Pro Trp Thr Ser Arg Gly Asp Val 
225                 230                 235                 240 


Leu Cys Cys Val Glu Asn Val Ala Leu His Gln Asn Ile Thr Ser Ile 
                245                 250                 255     


Ser Gln Ala Glu Ser Phe Thr Gly Asn Asn Thr Lys Asn Pro Gln Glu 
            260                 265                 270         


Thr His Asn Asn Glu Leu Lys Val Leu Val Pro Val Leu Ala Val Leu 
        275                 280                 285             


Ala Ala Ala Ala Phe Val Ser Phe Ile Ile Tyr Arg Arg Thr Arg Pro 
    290                 295                 300                 


His Arg Ser Tyr Thr Gly Pro Lys Thr Val Gln Leu Glu Leu Thr Asp 
305                 310                 315                 320 


His Ala 
        


<210> 61
<211> 199
<212> PRT
<213> Homo sapiens

<400> 61
Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210> 62
<211> 200
<212> PRT
<213> Mus musculus

<400> 62
Met Lys Pro Tyr Phe Cys Arg Val Phe Val Phe Cys Phe Leu Ile Arg 
1               5                   10                  15      


Leu Leu Thr Gly Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Leu Cys Leu Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asn Asn Pro Asp Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Trp Leu 
    130                 135                 140                 


Pro Val Gly Cys Ala Ala Phe Val Val Val Leu Leu Phe Gly Cys Ile 
145                 150                 155                 160 


Leu Ile Ile Trp Phe Ser Lys Lys Lys Tyr Gly Ser Ser Val His Asp 
                165                 170                 175     


Pro Asn Ser Glu Tyr Met Phe Met Ala Ala Val Asn Thr Asn Lys Lys 
            180                 185                 190         


Ser Arg Leu Ala Gly Val Thr Ser 
        195                 200 


<210> 63
<211> 495
<212> PRT
<213> Vesiculovirus indiana

<400> 63
Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
            20                  25                  30          


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
65                  70                  75                  80  


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
        115                 120                 125             


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
    130                 135                 140                 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
                165                 170                 175     


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
    210                 215                 220                 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
                325                 330                 335     


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
385                 390                 395                 400 


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
        435                 440                 445             


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
    450                 455                 460                 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
465                 470                 475                 480 


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                485                 490                 495 


<210> 64
<211> 1273
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<400> 64
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210> 65
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser His Lys Ala Ile 
1               5                   10                  15      


Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys 
            20                  25                  30          


Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser 
        35                  40                  45              


Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys 
    50                  55                  60                  


Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr 
65                  70                  75                  80  


Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His 
                85                  90                  95      


His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe 
            100                 105                 110         


Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser 
        115                 120                 125             


Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn 
    130                 135                 140                 


Leu Ile Ser Met Asp Ile 
145                 150 


<210> 66
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
                85                  90                  95      


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
            100                 105                 110         


Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser 
        115                 120                 125             


Asn Leu 
    130 


<210> 67
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 67
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
                85                  90                  95      


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
            100                 105                 110         


Ser Thr Thr 
        115 


<210> 68
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 68
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
                85                  90                  95      


Phe Ile Asn Gly 
            100 


<210> 69
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 69
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu 
                


<210> 70
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210> 71
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Gln 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
            20                  25                  30          


Arg 
    


<210> 72
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
            20                  25                  30          


Arg 
    


<210> 73
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr 
        35                  40  


<210> 74
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Thr Gly Ile Val Ser Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile His Thr Gly Asn Gln His Gln Ser Glu Pro 
        35                  40                  45              


Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys 
    50                  55                  60                  


Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Asn 
65                  70                  75  


<210> 75
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg 
1               5                   10                  15      


Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn 
            20                  25                  30          


Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys 
        35                  40                  45              


Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys 
    50                  55                  60                  


Val Thr Lys Leu 
65              


<210> 76
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu Arg Lys 
1               5                   10                  15      


Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys 
            20                  25                  30          


Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn Phe 
        35                  40                  45              


Val Cys Arg Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys Gly 
    50                  55                  60                  


Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys Val 
65                  70                  75                  80  


Thr Lys Leu 
            


<210> 77
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg 
1               5                   10                  15      


Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn 
            20                  25                  30          


Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys 
        35                  40                  45              


Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys 
    50                  55                  60                  


Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys Tyr 
65                  70                  75                  80  


Ser Val Ile 
            


<210> 78
<211> 59
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln 
1               5                   10                  15      


Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn Phe Val Cys Arg 
            20                  25                  30          


Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys Gly Leu Phe Gly 
        35                  40                  45              


Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys 
    50                  55                  


<210> 79
<211> 22
<212> PRT
<213> Vesiculovirus indiana

<400> 79
Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
1               5                   10                  15      


Val Leu Arg Val Gly Ile 
            20          


<210> 80
<211> 37
<212> PRT
<213> Vesiculovirus indiana

<400> 80
Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile 
1               5                   10                  15      


Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val 
            20                  25                  30          


Leu Arg Val Gly Ile 
        35          


<210> 81
<211> 53
<212> PRT
<213> Vesiculovirus indiana

<400> 81
Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro 
1               5                   10                  15      


Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala 
            20                  25                  30          


Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu 
        35                  40                  45              


Arg Val Gly Ile His 
    50              


<210> 82
<211> 81
<212> PRT
<213> Vesiculovirus indiana

<400> 82
Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe 
1               5                   10                  15      


Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu 
            20                  25                  30          


Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu 
        35                  40                  45              


Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe 
    50                  55                  60                  


Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly 
65                  70                  75                  80  


Ile 
    


<210> 83
<211> 25
<212> PRT
<213> Vesiculovirus indiana

<400> 83
His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
1               5                   10                  15      


Asp Ile Glu Met Asn Arg Leu Gly Lys 
            20                  25  


<210> 84
<211> 23
<212> PRT
<213> Influenza A virus

<400> 84
Ile Ile Thr Ile Gly Ser Val Cys Met Thr Ile Gly Met Ala Asn Leu 
1               5                   10                  15      


Ile Leu Gln Ile Gly Asn Ile 
            20              


<210> 85
<211> 23
<212> PRT
<213> Influenza A virus

<400> 85
Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val Val Ser 
1               5                   10                  15      


Leu Gly Ala Ile Ser Phe Trp 
            20              


<210> 86
<211> 52
<212> PRT
<213> Dengue virus

<400> 86
Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys Ile Gly 
1               5                   10                  15      


Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser 
            20                  25                  30          


Leu Ser Met Thr Cys Ile Ala Val Gly Met Val Thr Leu Tyr Leu Gly 
        35                  40                  45              


Val Met Val Gln 
    50          


<210> 87
<211> 43
<212> PRT
<213> Human immunodeficiency virus 1

<400> 87
Leu Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe 
1               5                   10                  15      


Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
            20                  25                  30          


Ser Phe Gln Thr His Leu Pro Thr Pro Arg Gly 
        35                  40              


<210> 88
<211> 60
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Spike protein S1 sequence

<400> 88
Trp Tyr Val Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Leu Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys 
            20                  25                  30          


Gly Ala Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser 
        35                  40                  45              


Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr 
    50                  55                  60  


<210> 89
<211> 60
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Spike protein S2 sequence

<400> 89
Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
1               5                   10                  15      


Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys 
            20                  25                  30          


Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser 
        35                  40                  45              


Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr 
    50                  55                  60  


<210> 90
<211> 31
<212> PRT
<213> Sindbis virus

<400> 90
Trp Leu Phe Ala Leu Phe Gly Gly Ala Ser Ser Leu Leu Ile Ile Gly 
1               5                   10                  15      


Leu Met Ile Phe Ala Cys Ser Met Met Leu Thr Ser Thr Arg Arg 
            20                  25                  30      


<210> 91
<211> 58
<212> PRT
<213> Measles morbillivirus

<400> 91
Met Ser Pro Gln Arg Asp Arg Ile Asn Ala Phe Tyr Lys Asp Asn Pro 
1               5                   10                  15      


His Pro Lys Gly Ser Arg Ile Val Ile Asn Arg Glu His Leu Met Ile 
            20                  25                  30          


Asp Arg Pro Tyr Val Leu Leu Ala Val Leu Phe Val Met Phe Leu Ser 
        35                  40                  45              


Leu Ile Gly Leu Leu Ala Ile Ala Gly Ile 
    50                  55              


<210> 92
<211> 26
<212> PRT
<213> Measles morbillivirus

<400> 92
Ile Val Tyr Ile Leu Ile Ala Val Cys Leu Gly Gly Leu Ile Gly Ile 
1               5                   10                  15      


Pro Ala Leu Ile Cys Cys Cys Arg Gly Arg 
            20                  25      


<210> 93
<211> 49
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RD114 TM sequence

<400> 93
Leu Leu Thr Leu Leu Leu Ile Leu Thr Ile Gly Pro Cys Val Phe Ser 
1               5                   10                  15      


Arg Leu Met Ala Phe Ile Asn Asp Arg Leu Asn Val Val His Ala Met 
            20                  25                  30          


Val Leu Ala Gln Gln Tyr Gln Ala Leu Lys Ala Glu Glu Glu Ala Gln 
        35                  40                  45              


Asp 
    


<210> 94
<211> 49
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      BaEV TM sequence

<400> 94
Leu Leu Thr Leu Leu Leu Leu Leu Thr Ile Gly Pro Cys Ile Phe Asn 
1               5                   10                  15      


Arg Leu Thr Ala Phe Ile Asn Asp Lys Leu Asn Ile Ile His Ala Met 
            20                  25                  30          


Val Leu Thr Gln Gln Tyr Gln Val Leu Arg Thr Asp Glu Glu Ala Gln 
        35                  40                  45              


Asp 
    


<210> 95
<211> 182
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      GP120 TM sequence

<400> 95
Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile 
1               5                   10                  15      


Ile Phe Ala Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
            20                  25                  30          


Pro Leu Ser Phe Gln Ile His Ser His His Gln Arg Glu Pro Asp Arg 
        35                  40                  45              


Pro Glu Gly Ile Glu Glu Gly Gly Gly Glu Gln Gly Lys Asp Arg Ser 
    50                  55                  60                  


Val Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp Asp Asp Leu Arg 
65                  70                  75                  80  


Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Phe Ile Leu Val 
                85                  90                  95      


Ala Ala Arg Thr Val Glu Leu Leu Gly His Ser Ser Leu Lys Gly Leu 
            100                 105                 110         


Arg Leu Gly Trp Glu Gly Leu Lys Tyr Leu Gly Asn Leu Leu Ile Tyr 
        115                 120                 125             


Trp Ser Gln Glu Leu Lys Thr Ser Ala Ile Ser Leu Phe Asp Thr Ile 
    130                 135                 140                 


Ala Ile Ala Val Ala Gly Trp Thr Asp Arg Val Ile Glu Ile Ala Gln 
145                 150                 155                 160 


Arg Ala Gly Arg Ala Ile Ile His Ile Pro Arg Arg Ile Arg Gln Gly 
                165                 170                 175     


Leu Glu Arg Ala Leu Gln 
            180         


<210> 96
<211> 585
<212> PRT
<213> Homo sapiens

<400> 96
Met Glu Lys Lys Trp Lys Tyr Cys Ala Val Tyr Tyr Ile Ile Gln Ile 
1               5                   10                  15      


His Phe Val Lys Gly Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn 
            20                  25                  30          


Val Tyr Ala Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln 
        35                  40                  45              


Thr Val Gly Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys 
    50                  55                  60                  


Ile Asp Leu Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala 
65                  70                  75                  80  


Tyr Gly Arg Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu 
                85                  90                  95      


Asn Gly Ser Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val 
            100                 105                 110         


Ser Gly Arg Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln 
        115                 120                 125             


Thr Lys Ile Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu 
    130                 135                 140                 


Trp Asn Ser Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu 
145                 150                 155                 160 


Ile Pro Cys Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr 
                165                 170                 175     


Tyr Ala Trp Ser Val Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu 
            180                 185                 190         


Ser Lys Gly Ile Lys Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser 
        195                 200                 205             


Gln Asn His Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys 
    210                 215                 220                 


Leu Gly Thr Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp 
225                 230                 235                 240 


Asp Gly Arg Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile 
                245                 250                 255     


Leu Arg Ser Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro 
            260                 265                 270         


Val Ile Val Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe 
        275                 280                 285             


Thr Cys Leu Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe 
    290                 295                 300                 


Ile Asp Gly Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr 
305                 310                 315                 320 


Asn Glu Glu Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val 
                325                 330                 335     


Leu Thr Arg Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr 
            340                 345                 350         


Ile Trp Cys Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn 
        355                 360                 365             


Ile Ser Ser Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser 
    370                 375                 380                 


Thr Asp Pro Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro 
385                 390                 395                 400 


Ser Pro Ala Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser 
                405                 410                 415     


Val Thr Leu Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln 
            420                 425                 430         


Pro Ser Asn Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr 
        435                 440                 445             


Ser Ser Gly Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu 
    450                 455                 460                 


Thr Tyr Ser Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn 
465                 470                 475                 480 


Val Phe Thr Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala 
                485                 490                 495     


Asn Gly Ser Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val 
            500                 505                 510         


Asn Lys Pro Lys Asp Gly Met Ser Trp Pro Val Ile Val Ala Ala Leu 
        515                 520                 525             


Leu Phe Cys Cys Met Ile Leu Phe Gly Leu Gly Val Arg Lys Trp Cys 
    530                 535                 540                 


Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro Pro 
545                 550                 555                 560 


Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro Asn Glu Ser Asp 
                565                 570                 575     


Leu Pro Tyr His Glu Met Glu Thr Leu 
            580                 585 


<210> 97
<211> 602
<212> PRT
<213> Mus sp.

<400> 97
Met Gly Arg Lys Trp Thr Tyr Cys Val Val Tyr Thr Ile Ile Gln Ile 
1               5                   10                  15      


Gln Phe Phe Arg Gly Val Trp Glu Glu Leu Phe Asn Val Gly Asp Asp 
            20                  25                  30          


Val Tyr Ala Leu Pro Gly Ser Asp Ile Asn Leu Thr Cys Gln Thr Lys 
        35                  40                  45              


Glu Lys Asn Phe Leu Val Gln Met Gln Trp Ser Lys Val Thr Asp Lys 
    50                  55                  60                  


Asn Asp Met Ile Ala Leu Tyr His Pro Gln Tyr Gly Leu Tyr Cys Gly 
65                  70                  75                  80  


Gln Glu His Ala Cys Glu Ser Gln Val Ala Ala Thr Glu Thr Glu Lys 
                85                  90                  95      


Gly Val Thr Asn Trp Thr Leu Tyr Leu Arg Asn Ile Ser Ser Ala Leu 
            100                 105                 110         


Gly Gly Lys Tyr Glu Cys Ile Phe Thr Leu Tyr Pro Glu Gly Ile Lys 
        115                 120                 125             


Thr Thr Val Tyr Asn Leu Ile Val Glu Pro Tyr Thr Gln Asp Glu His 
    130                 135                 140                 


Asn Tyr Thr Ile Glu Ile Glu Thr Asn Arg Thr Leu Glu Ile Pro Cys 
145                 150                 155                 160 


Phe Gln Asn Thr Ser Ser Glu Ile Pro Pro Arg Phe Thr Phe Ser Trp 
                165                 170                 175     


Leu Val Glu Lys Asp Gly Val Glu Glu Val Leu Phe Thr His His His 
            180                 185                 190         


His Val Asn Asn Ser Thr Ser Phe Lys Gly Arg Ile Arg Leu Gly Gly 
        195                 200                 205             


Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Gln Asp Asp Gly Arg 
    210                 215                 220                 


Thr Phe Ser Cys His Leu Thr Val Asn Pro Leu Lys Ala Trp Lys Met 
225                 230                 235                 240 


Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Leu Met Thr Val 
                245                 250                 255     


Glu Asn Ser Thr Met Asp Val Leu Gly Glu Arg Val Phe Thr Cys Leu 
            260                 265                 270         


Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe Ile Asp Gly 
        275                 280                 285             


Arg Phe Leu Gln Gly Asn Glu Glu Gly Ile Tyr Ile Thr Asn Glu Glu 
    290                 295                 300                 


Lys Asn Cys Ser Ser Gly Phe Trp Glu Leu Lys Ser Val Leu Thr Arg 
305                 310                 315                 320 


Met His Ser Gly Pro Ser Gln Ser Asn Asn Met Thr Ala Trp Cys Met 
                325                 330                 335     


Ala Leu Ser Pro Gly Pro Arg Asn Lys Met Trp Asn Thr Ser Ser Gln 
            340                 345                 350         


Pro Ile Thr Val Ser Phe Asp Ser Val Ile Ala Pro Thr Lys His Leu 
        355                 360                 365             


Pro Thr Val Thr Gly Ser Thr Leu Gly Thr Gln Pro Phe Ser Asp Ala 
    370                 375                 380                 


Gly Val Ser Pro Thr Gly Tyr Leu Ala Thr Pro Ser Val Thr Ile Val 
385                 390                 395                 400 


Asp Glu Asn Gly Leu Thr Pro Asp Ala Thr Pro Gln Thr Ser Asn Ser 
                405                 410                 415     


Ser Met Thr Thr Lys Asp Gly Asn Tyr Leu Glu Ala Ser Ser Gly Thr 
            420                 425                 430         


Asp Ala Lys Asn Ser Ser Arg Ala Ala Ala Ser Ser Lys Ser Gly Ser 
        435                 440                 445             


Trp Pro Phe Pro Phe Thr Ser Pro Pro Glu Trp His Ser Leu Pro Gly 
    450                 455                 460                 


Thr Ser Thr Gly Pro Gln Glu Pro Asp Ser Pro Val Ser Trp Ile Pro 
465                 470                 475                 480 


Ser Glu Val His Thr Ser Ala Pro Leu Asp Ala Ser Leu Ala Pro His 
                485                 490                 495     


Asp Thr Ile Ile Ser Thr Thr Thr Glu Phe Pro Asn Val Leu Thr Thr 
            500                 505                 510         


Ala Asn Gly Thr Thr Lys Ile Asp His Gly Pro Ile Thr Ser Ile Ile 
        515                 520                 525             


Val Asn Gln Pro Ser Asp Gly Met Ser Trp Pro Val Leu Val Ala Ala 
    530                 535                 540                 


Leu Leu Phe Phe Cys Thr Leu Leu Phe Gly Leu Gly Val Arg Lys Trp 
545                 550                 555                 560 


Tyr Arg Tyr Gln Asn Glu Ile Met Glu Arg Pro Pro Pro Phe Lys Pro 
                565                 570                 575     


Pro Pro Pro Pro Ile Lys Tyr Thr Tyr Ile Gln Glu Pro Ile Gly Cys 
            580                 585                 590         


Asp Leu Cys Cys His Glu Met Glu Val Leu 
        595                 600         


<210> 98
<211> 282
<212> PRT
<213> Homo sapiens

<400> 98
Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210> 99
<211> 283
<212> PRT
<213> Mus sp.

<400> 99
Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly Pro Ser Pro Cys Val Phe Ser Ser Ala Phe Val Ala Gly Trp Ala 
            260                 265                 270         


Leu Leu Ser Leu Ser Cys Cys Leu Met Leu Arg 
        275                 280             


<210> 100
<211> 467
<212> PRT
<213> Homo sapiens

<400> 100
Met Leu Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Val 
1               5                   10                  15      


Glu Gly Gln Lys Ser Asn Arg Lys Asp Tyr Ser Leu Thr Met Gln Ser 
            20                  25                  30          


Ser Val Thr Val Gln Glu Gly Met Cys Val His Val Arg Cys Ser Phe 
        35                  40                  45              


Ser Tyr Pro Val Asp Ser Gln Thr Asp Ser Asp Pro Val His Gly Tyr 
    50                  55                  60                  


Trp Phe Arg Ala Gly Asn Asp Ile Ser Trp Lys Ala Pro Val Ala Thr 
65                  70                  75                  80  


Asn Asn Pro Ala Trp Ala Val Gln Glu Glu Thr Arg Asp Arg Phe His 
                85                  90                  95      


Leu Leu Gly Asp Pro Gln Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp 
            100                 105                 110         


Ala Arg Met Ser Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly 
        115                 120                 125             


Asn Ile Lys Trp Asn Tyr Lys Tyr Asp Gln Leu Ser Val Asn Val Thr 
    130                 135                 140                 


Ala Leu Thr His Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser 
145                 150                 155                 160 


Gly Cys Phe Gln Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln 
                165                 170                 175     


Gly Thr Pro Pro Met Ile Ser Trp Met Gly Thr Ser Val Ser Pro Leu 
            180                 185                 190         


His Pro Ser Thr Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro 
        195                 200                 205             


Gln His His Gly Thr Ser Leu Thr Cys Gln Val Thr Leu Pro Gly Ala 
    210                 215                 220                 


Gly Val Thr Thr Asn Arg Thr Ile Gln Leu Asn Val Ser Tyr Pro Pro 
225                 230                 235                 240 


Gln Asn Leu Thr Val Thr Val Phe Gln Gly Glu Gly Thr Ala Ser Thr 
                245                 250                 255     


Ala Leu Gly Asn Ser Ser Ser Leu Ser Val Leu Glu Gly Gln Ser Leu 
            260                 265                 270         


Arg Leu Val Cys Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Trp 
        275                 280                 285             


Thr Trp Arg Ser Leu Thr Leu Tyr Pro Ser Gln Pro Ser Asn Pro Leu 
    290                 295                 300                 


Val Leu Glu Leu Gln Val His Leu Gly Asp Glu Gly Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Ser Leu Gly Ser Gln His Val Ser Leu Asn Leu Ser 
                325                 330                 335     


Leu Gln Gln Glu Tyr Thr Gly Lys Met Arg Pro Val Ser Gly Val Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Gly Ala Gly Ala Thr Ala Leu Val Phe Leu Ser 
        355                 360                 365             


Phe Cys Val Ile Phe Ile Val Val Arg Ser Cys Arg Lys Lys Ser Ala 
    370                 375                 380                 


Arg Pro Ala Ala Asp Val Gly Asp Ile Gly Met Lys Asp Ala Asn Thr 
385                 390                 395                 400 


Ile Arg Gly Ser Ala Ser Gln Gly Asn Leu Thr Glu Ser Trp Ala Asp 
                405                 410                 415     


Asp Asn Pro Arg His His Gly Leu Ala Ala His Ser Ser Gly Glu Glu 
            420                 425                 430         


Arg Glu Ile Gln Tyr Ala Pro Leu Ser Phe His Lys Gly Glu Pro Gln 
        435                 440                 445             


Asp Leu Ser Gly Gln Glu Ala Thr Asn Asn Glu Tyr Ser Glu Ile Lys 
    450                 455                 460                 


Ile Pro Lys 
465         


<210> 101
<211> 463
<212> PRT
<213> Homo sapiens

<400> 101
Met Leu Leu Leu Leu Leu Pro Leu Leu Trp Gly Arg Glu Arg Ala Glu 
1               5                   10                  15      


Gly Gln Thr Ser Lys Leu Leu Thr Met Gln Ser Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val His Val Pro Cys Ser Phe Ser Tyr Pro Ser His 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Pro Val Val His Gly Tyr Trp Phe Arg Glu 
    50                  55                  60                  


Gly Ala Asn Thr Asp Gln Asp Ala Pro Val Ala Thr Asn Asn Pro Ala 
65                  70                  75                  80  


Arg Ala Val Trp Glu Glu Thr Arg Asp Arg Phe His Leu Leu Gly Asp 
                85                  90                  95      


Pro His Thr Lys Asn Cys Thr Leu Ser Ile Arg Asp Ala Arg Arg Ser 
            100                 105                 110         


Asp Ala Gly Arg Tyr Phe Phe Arg Met Glu Lys Gly Ser Ile Lys Trp 
        115                 120                 125             


Asn Tyr Lys His His Arg Leu Ser Val Asn Val Thr Ala Leu Thr His 
    130                 135                 140                 


Arg Pro Asn Ile Leu Ile Pro Gly Thr Leu Glu Ser Gly Cys Pro Gln 
145                 150                 155                 160 


Asn Leu Thr Cys Ser Val Pro Trp Ala Cys Glu Gln Gly Thr Pro Pro 
                165                 170                 175     


Met Ile Ser Trp Ile Gly Thr Ser Val Ser Pro Leu Asp Pro Ser Thr 
            180                 185                 190         


Thr Arg Ser Ser Val Leu Thr Leu Ile Pro Gln Pro Gln Asp His Gly 
        195                 200                 205             


Thr Ser Leu Thr Cys Gln Val Thr Phe Pro Gly Ala Ser Val Thr Thr 
    210                 215                 220                 


Asn Lys Thr Val His Leu Asn Val Ser Tyr Pro Pro Gln Asn Leu Thr 
225                 230                 235                 240 


Met Thr Val Phe Gln Gly Asp Gly Thr Val Ser Thr Val Leu Gly Asn 
                245                 250                 255     


Gly Ser Ser Leu Ser Leu Pro Glu Gly Gln Ser Leu Arg Leu Val Cys 
            260                 265                 270         


Ala Val Asp Ala Val Asp Ser Asn Pro Pro Ala Arg Leu Ser Leu Ser 
        275                 280                 285             


Trp Arg Gly Leu Thr Leu Cys Pro Ser Gln Pro Ser Asn Pro Gly Val 
    290                 295                 300                 


Leu Glu Leu Pro Trp Val His Leu Arg Asp Ala Ala Glu Phe Thr Cys 
305                 310                 315                 320 


Arg Ala Gln Asn Pro Leu Gly Ser Gln Gln Val Tyr Leu Asn Val Ser 
                325                 330                 335     


Leu Gln Ser Lys Ala Thr Ser Gly Val Thr Gln Gly Val Val Gly Gly 
            340                 345                 350         


Ala Gly Ala Thr Ala Leu Val Phe Leu Ser Phe Cys Val Ile Phe Val 
        355                 360                 365             


Val Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val 
    370                 375                 380                 


Gly Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser 
385                 390                 395                 400 


Gln Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln 
                405                 410                 415     


Pro Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln 
            420                 425                 430         


Tyr Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly 
        435                 440                 445             


Gln Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 
    450                 455                 460             


<210> 102
<211> 260
<212> PRT
<213> Homo sapiens

<400> 102
Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210> 103
<211> 250
<212> PRT
<213> Mus sp.

<400> 103
Met Ala Trp Pro Pro Pro Tyr Trp Leu Cys Met Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Leu Ala Pro Asn Ser Cys Pro Asp Lys His Tyr 
            20                  25                  30          


Trp Thr Gly Gly Gly Leu Cys Cys Arg Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Phe Val Lys Asp Cys Glu Gln Asp Arg Thr Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Thr Ser Phe Ser Pro Asp Tyr His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Phe Leu Ile Arg Asn Cys 
                85                  90                  95      


Thr Val Thr Ala Asn Ala Glu Cys Ser Cys Ser Lys Asn Trp Gln Cys 
            100                 105                 110         


Arg Asp Gln Glu Cys Thr Glu Cys Asp Pro Pro Leu Asn Pro Ala Leu 
        115                 120                 125             


Thr Arg Gln Pro Ser Glu Thr Pro Ser Pro Gln Pro Pro Pro Thr His 
    130                 135                 140                 


Leu Pro His Gly Thr Glu Lys Pro Ser Trp Pro Leu His Arg Gln Leu 
145                 150                 155                 160 


Pro Asn Ser Thr Val Tyr Ser Gln Arg Ser Ser His Arg Pro Leu Cys 
                165                 170                 175     


Ser Ser Asp Cys Ile Arg Ile Phe Val Thr Phe Ser Ser Met Phe Leu 
            180                 185                 190         


Ile Phe Val Leu Gly Ala Ile Leu Phe Phe His Gln Arg Arg Asn His 
        195                 200                 205             


Gly Pro Asn Glu Asp Arg Gln Ala Val Pro Glu Glu Pro Cys Pro Tyr 
    210                 215                 220                 


Ser Cys Pro Arg Glu Glu Glu Gly Ser Ala Ile Pro Ile Gln Glu Asp 
225                 230                 235                 240 


Tyr Arg Lys Pro Glu Pro Ala Phe Tyr Pro 
                245                 250 


<210> 104
<211> 220
<212> PRT
<213> Homo sapiens

<400> 104
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 105
<211> 218
<212> PRT
<213> Mus sp.

<400> 105
Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210> 106
<211> 552
<212> PRT
<213> Homo sapiens

<400> 106
Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Ala Gln Val Val His Val 
    130                 135                 140                 


Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His 
145                 150                 155                 160 


Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly 
                165                 170                 175     


His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu 
            180                 185                 190         


Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln 
        195                 200                 205             


Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp 
    210                 215                 220                 


Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp 
225                 230                 235                 240 


Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe 
                245                 250                 255     


Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly 
            260                 265                 270         


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
        275                 280                 285             


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
    290                 295                 300                 


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
305                 310                 315                 320 


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
                325                 330                 335     


Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser 
            340                 345                 350         


Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe 
        355                 360                 365             


His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr 
    370                 375                 380                 


Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala 
385                 390                 395                 400 


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
                405                 410                 415     


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
            420                 425                 430         


Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly 
        435                 440                 445             


Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val 
    450                 455                 460                 


Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val 
465                 470                 475                 480 


Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu 
                485                 490                 495     


Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe 
            500                 505                 510         


Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala 
        515                 520                 525             


Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
    530                 535                 540                 


Gly Gln Asp Pro Thr His Leu Val 
545                 550         


<210> 107
<211> 539
<212> PRT
<213> Mus sp.

<400> 107
Met Ala Thr Ile Ala Leu Pro Trp Ser Leu Ser Leu Tyr Val Phe Leu 
1               5                   10                  15      


Leu Leu Leu Ala Thr Pro Trp Ala Ser Ala Ala Val Lys Asn Cys Ser 
            20                  25                  30          


His Leu Glu Cys Phe Tyr Asn Ser Arg Ala Asn Val Ser Cys Met Trp 
        35                  40                  45              


Ser His Glu Glu Ala Leu Asn Val Thr Thr Cys His Val His Ala Lys 
    50                  55                  60                  


Ser Asn Leu Arg His Trp Asn Lys Thr Cys Glu Leu Thr Leu Val Arg 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ser Phe Pro Glu Ser 
                85                  90                  95      


Gln Ser Leu Thr Ser Val Asp Leu Leu Asp Ile Asn Val Val Cys Trp 
            100                 105                 110         


Glu Glu Lys Gly Trp Arg Arg Val Lys Thr Cys Asp Phe His Pro Phe 
        115                 120                 125             


Asp Asn Leu Arg Leu Val Ala Pro His Ser Leu Gln Val Leu His Ile 
    130                 135                 140                 


Asp Thr Gln Arg Cys Asn Ile Ser Trp Lys Val Ser Gln Val Ser His 
145                 150                 155                 160 


Tyr Ile Glu Pro Tyr Leu Glu Phe Glu Ala Arg Arg Arg Leu Leu Gly 
                165                 170                 175     


His Ser Trp Glu Asp Ala Ser Val Leu Ser Leu Lys Gln Arg Gln Gln 
            180                 185                 190         


Trp Leu Phe Leu Glu Met Leu Ile Pro Ser Thr Ser Tyr Glu Val Gln 
        195                 200                 205             


Val Arg Val Lys Ala Gln Arg Asn Asn Thr Gly Thr Trp Ser Pro Trp 
    210                 215                 220                 


Ser Gln Pro Leu Thr Phe Arg Thr Arg Pro Ala Asp Pro Met Lys Glu 
225                 230                 235                 240 


Ile Leu Pro Met Ser Trp Leu Arg Tyr Leu Leu Leu Val Leu Gly Cys 
                245                 250                 255     


Phe Ser Gly Phe Phe Ser Cys Val Tyr Ile Leu Val Lys Cys Arg Tyr 
            260                 265                 270         


Leu Gly Pro Trp Leu Lys Thr Val Leu Lys Cys His Ile Pro Asp Pro 
        275                 280                 285             


Ser Glu Phe Phe Ser Gln Leu Ser Ser Gln His Gly Gly Asp Leu Gln 
    290                 295                 300                 


Lys Trp Leu Ser Ser Pro Val Pro Leu Ser Phe Phe Ser Pro Ser Gly 
305                 310                 315                 320 


Pro Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Asp Gly Asp Ser Lys 
                325                 330                 335     


Ala Val Gln Leu Leu Leu Leu Gln Lys Asp Ser Ala Pro Leu Pro Ser 
            340                 345                 350         


Pro Ser Gly His Ser Gln Ala Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
        355                 360                 365             


Phe Phe His Leu Pro Asn Ala Leu Glu Ile Glu Ser Cys Gln Val Tyr 
    370                 375                 380                 


Phe Thr Tyr Asp Pro Cys Val Glu Glu Glu Val Glu Glu Asp Gly Ser 
385                 390                 395                 400 


Arg Leu Pro Glu Gly Ser Pro His Pro Pro Leu Leu Pro Leu Ala Gly 
                405                 410                 415     


Glu Gln Asp Asp Tyr Cys Ala Phe Pro Pro Arg Asp Asp Leu Leu Leu 
            420                 425                 430         


Phe Ser Pro Ser Leu Ser Thr Pro Asn Thr Ala Tyr Gly Gly Ser Arg 
        435                 440                 445             


Ala Pro Glu Glu Arg Ser Pro Leu Ser Leu His Glu Gly Leu Pro Ser 
    450                 455                 460                 


Leu Ala Ser Arg Asp Leu Met Gly Leu Gln Arg Pro Leu Glu Arg Met 
465                 470                 475                 480 


Pro Glu Gly Asp Gly Glu Gly Leu Ser Ala Asn Ser Ser Gly Glu Gln 
                485                 490                 495     


Ala Ser Val Pro Glu Gly Asn Leu His Gly Gln Asp Gln Asp Arg Gly 
            500                 505                 510         


Gln Gly Pro Ile Leu Thr Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
        515                 520                 525             


Glu Leu Gln Ala Gln Asp Ser Val His Leu Ile 
    530                 535                 


<210> 108
<211> 241
<212> PRT
<213> Homo sapiens

<400> 108
Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210> 109
<211> 228
<212> PRT
<213> Mus sp.

<400> 109
Met Gly Ala Trp Ala Met Leu Tyr Gly Val Ser Met Leu Cys Val Leu 
1               5                   10                  15      


Asp Leu Gly Gln Pro Ser Val Val Glu Glu Pro Gly Cys Gly Pro Gly 
            20                  25                  30          


Lys Val Gln Asn Gly Ser Gly Asn Asn Thr Arg Cys Cys Ser Leu Tyr 
        35                  40                  45              


Ala Pro Gly Lys Glu Asp Cys Pro Lys Glu Arg Cys Ile Cys Val Thr 
    50                  55                  60                  


Pro Glu Tyr His Cys Gly Asp Pro Gln Cys Lys Ile Cys Lys His Tyr 
65                  70                  75                  80  


Pro Cys Gln Pro Gly Gln Arg Val Glu Ser Gln Gly Asp Ile Val Phe 
                85                  90                  95      


Gly Phe Arg Cys Val Ala Cys Ala Met Gly Thr Phe Ser Ala Gly Arg 
            100                 105                 110         


Asp Gly His Cys Arg Leu Trp Thr Asn Cys Ser Gln Phe Gly Phe Leu 
        115                 120                 125             


Thr Met Phe Pro Gly Asn Lys Thr His Asn Ala Val Cys Ile Pro Glu 
    130                 135                 140                 


Pro Leu Pro Thr Glu Gln Tyr Gly His Leu Thr Val Ile Phe Leu Val 
145                 150                 155                 160 


Met Ala Ala Cys Ile Phe Phe Leu Thr Thr Val Gln Leu Gly Leu His 
                165                 170                 175     


Ile Trp Gln Leu Arg Arg Gln His Met Cys Pro Arg Glu Thr Gln Pro 
            180                 185                 190         


Phe Ala Glu Val Gln Leu Ser Ala Glu Asp Ala Cys Ser Phe Gln Phe 
        195                 200                 205             


Pro Glu Glu Glu Arg Gly Glu Gln Thr Glu Glu Lys Cys His Leu Gly 
    210                 215                 220                 


Gly Arg Trp Pro 
225             


<210> 110
<211> 193
<212> PRT
<213> Homo sapiens

<400> 110
Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210> 111
<211> 195
<212> PRT
<213> Mus sp.

<400> 111
Met Pro Glu Glu Gly Arg Pro Cys Pro Trp Val Arg Trp Ser Gly Thr 
1               5                   10                  15      


Ala Phe Gln Arg Gln Trp Pro Trp Leu Leu Leu Val Val Phe Ile Thr 
            20                  25                  30          


Val Phe Cys Cys Trp Phe His Cys Ser Gly Leu Leu Ser Lys Gln Gln 
        35                  40                  45              


Gln Arg Leu Leu Glu His Pro Glu Pro His Thr Ala Glu Leu Gln Leu 
    50                  55                  60                  


Asn Leu Thr Val Pro Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly 
65                  70                  75                  80  


Pro Ala Leu Gly Arg Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly 
                85                  90                  95      


His Leu Arg Ile His Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val 
            100                 105                 110         


Thr Leu Ala Asn Cys Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala 
        115                 120                 125             


Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu 
    130                 135                 140                 


Leu Arg Gly Arg Phe Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu 
145                 150                 155                 160 


Thr Tyr Leu Val His Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro 
                165                 170                 175     


Leu Leu Pro Ser Arg Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp 
            180                 185                 190         


Ile Cys Pro 
        195 


<210> 112
<211> 153
<212> PRT
<213> Homo sapiens

<400> 112
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 113
<211> 169
<212> PRT
<213> Mus sp.

<400> 113
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210> 114
<211> 199
<212> PRT
<213> Homo sapiens

<400> 114
Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210> 115
<211> 173
<212> PRT
<213> Mus sp.

<400> 115
Met Glu Glu Met Pro Leu Arg Glu Ser Ser Pro Gln Arg Ala Glu Arg 
1               5                   10                  15      


Cys Lys Lys Ser Trp Leu Leu Cys Ile Val Ala Leu Leu Leu Met Leu 
            20                  25                  30          


Leu Cys Ser Leu Gly Thr Leu Ile Tyr Thr Ser Leu Lys Pro Thr Ala 
        35                  40                  45              


Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp His 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly Lys 
65                  70                  75                  80  


Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val Ile 
                85                  90                  95      


Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val Gln 
            100                 105                 110         


Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe Gln 
        115                 120                 125             


Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr Asn Thr Tyr 
145                 150                 155                 160 


Trp Gly Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
                165                 170             


<210> 116
<211> 428
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 116
Met Gly Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          


Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  


Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  


Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      


Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 


Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Lys Pro Glu Gly Arg Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Asp Ile 
            180                 185                 190         


Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
        195                 200                 205             


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
    210                 215                 220                 


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
225                 230                 235                 240 


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
                245                 250                 255     


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
            260                 265                 270         


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
        275                 280                 285             


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
    290                 295                 300                 


Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser 
305                 310                 315                 320 


Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln 
                325                 330                 335     


Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp 
            340                 345                 350         


Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile 
        355                 360                 365             


Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser 
    370                 375                 380                 


Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg 
385                 390                 395                 400 


Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln 
                405                 410                 415     


Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            420                 425             


<210> 117
<211> 475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 117
Met Arg Ile Phe Ala Gly Ile Ile Phe Thr Ala Cys Cys His Leu Leu 
1               5                   10                  15      


Arg Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu 
        35                  40                  45              


Asp Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val 
    50                  55                  60                  


Ile Gln Phe Val Ala Gly Glu Glu Asp Leu Lys Pro Gln His Ser Asn 
65                  70                  75                  80  


Phe Arg Gly Arg Ala Ser Leu Pro Lys Asp Gln Leu Leu Lys Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Cys Cys Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Leu 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Arg Lys Ile Asn Gln Arg Ile Ser Val Asp 
    130                 135                 140                 


Pro Ala Thr Ser Glu His Glu Leu Ile Cys Gln Ala Glu Gly Tyr Pro 
145                 150                 155                 160 


Glu Ala Glu Val Ile Trp Thr Asn Ser Asp His Gln Pro Val Ser Gly 
                165                 170                 175     


Lys Arg Ser Val Thr Thr Ser Arg Thr Glu Gly Met Leu Leu Asn Val 
            180                 185                 190         


Thr Ser Ser Leu Arg Val Asn Ala Thr Ala Asn Asp Val Phe Tyr Cys 
        195                 200                 205             


Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn His Thr Ala Glu Leu Ile 
    210                 215                 220                 


Ile Pro Glu Leu Pro Ala Thr His Pro Pro Gln Asn Arg Asp Ile Ile 
225                 230                 235                 240 


Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys 
                245                 250                 255     


Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser 
            260                 265                 270         


Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys 
        275                 280                 285             


Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr 
    290                 295                 300                 


Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His 
305                 310                 315                 320 


His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe 
                325                 330                 335     


Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser 
            340                 345                 350         


Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn 
        355                 360                 365             


Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val 
    370                 375                 380                 


Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp 
385                 390                 395                 400 


Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu 
                405                 410                 415     


Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe 
            420                 425                 430         


Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val 
        435                 440                 445             


Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile 
    450                 455                 460                 


Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
465                 470                 475 


<210> 118
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 118
Met Ile Gly Gln Ala Val Leu Phe Thr Thr Phe Leu Leu Leu Arg Ala 
1               5                   10                  15      


His Gln Gly Gln Asp Cys Pro Asp Ser Ser Glu Glu Val Val Gly Val 
            20                  25                  30          


Ser Gly Lys Pro Val Gln Leu Arg Pro Ser Asn Ile Gln Thr Lys Asp 
        35                  40                  45              


Val Ser Val Gln Trp Lys Lys Thr Glu Gln Gly Ser His Arg Lys Ile 
    50                  55                  60                  


Glu Ile Leu Asn Trp Tyr Asn Asp Gly Pro Ser Trp Ser Asn Val Ser 
65                  70                  75                  80  


Phe Ser Asp Ile Tyr Gly Phe Asp Tyr Gly Asp Phe Ala Leu Ser Ile 
                85                  90                  95      


Lys Ser Ala Lys Leu Gln Asp Ser Gly His Tyr Leu Leu Glu Ile Thr 
            100                 105                 110         


Asn Thr Gly Gly Lys Val Cys Asn Lys Asn Phe Gln Leu Leu Ile Leu 
        115                 120                 125             


Asp His Val Glu Thr Pro Asn Leu Lys Ala Gln Trp Lys Pro Trp Thr 
    130                 135                 140                 


Asn Gly Thr Cys Gln Leu Phe Leu Ser Cys Leu Val Thr Lys Asp Asp 
145                 150                 155                 160 


Asn Val Ser Tyr Ala Leu Tyr Arg Gly Ser Thr Leu Ile Ser Asn Gln 
                165                 170                 175     


Arg Asn Ser Thr His Trp Glu Asn Gln Ile Asp Ala Ser Ser Leu His 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Ser Asn Arg Ala Ser Trp Ala Asn His Thr 
        195                 200                 205             


Leu Asn Phe Thr His Gly Cys Gln Ser Val Pro Ser Asn Phe Arg Phe 
    210                 215                 220                 


Leu Pro Asp Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys 
225                 230                 235                 240 


Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr 
                245                 250                 255     


His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser 
            260                 265                 270         


Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro 
        275                 280                 285             


Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val 
    290                 295                 300                 


Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
305                 310                 315                 320 


Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro 
                325                 330                 335     


Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly 
            340                 345                 350         


Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser 
        355                 360                 365             


Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser 
    370                 375                 380                 


Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser 
385                 390                 395                 400 


Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser 
                405                 410                 415     


Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe 
            420                 425                 430         


Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr 
        435                 440                 445             


Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
    450                 455                 460                 


<210> 119
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 119
Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Asp Ile Ile Gln Ala 
    210                 215                 220                 


Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe 
225                 230                 235                 240 


Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr 
                245                 250                 255     


Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly 
            260                 265                 270         


Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr 
        275                 280                 285             


Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val 
    290                 295                 300                 


Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn 
305                 310                 315                 320 


Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr 
                325                 330                 335     


Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly 
            340                 345                 350         


Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu 
        355                 360                 365             


His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser 
    370                 375                 380                 


Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val 
385                 390                 395                 400 


Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe 
                405                 410                 415     


Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile 
            420                 425                 430         


His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
        435                 440                 445             


Asp Ile Glu Met Asn Arg Leu Gly Lys 
    450                 455         


<210> 120
<211> 429
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 120
Met Thr Cys Leu Gly Leu Arg Arg Tyr Lys Ala Gln Leu Gln Leu Pro 
1               5                   10                  15      


Ser Arg Thr Trp Pro Phe Val Ala Leu Leu Thr Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala 
        35                  40                  45              


Ser Ser His Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His 
    50                  55                  60                  


Asn Thr Asp Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln 
65                  70                  75                  80  


Met Thr Glu Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly 
                85                  90                  95      


Phe Leu Asp Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Val Ala Val Ser Leu Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Val Thr Ala Val Ser Leu Ser Lys Arg Ile Gln Asp 
            180                 185                 190         


Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr 
        195                 200                 205             


Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile 
    210                 215                 220                 


Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln 
225                 230                 235                 240 


Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys 
                245                 250                 255     


Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr 
            260                 265                 270         


Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser 
        275                 280                 285             


Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His 
    290                 295                 300                 


Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp 
305                 310                 315                 320 


Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala 
                325                 330                 335     


Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro 
            340                 345                 350         


Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro 
        355                 360                 365             


Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala 
    370                 375                 380                 


Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu 
385                 390                 395                 400 


Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 
                405                 410                 415     


Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            420                 425                 


<210> 121
<211> 501
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 121
Met Ala Asp Ser Phe Ser Leu Asn Asp Ala Leu Ala Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Tyr Pro Gly Ala Trp Gly Asn Gln Pro Gly Ala 
            20                  25                  30          


Gly Gly Tyr Pro Gly Ala Ala Tyr Pro Gly Ala Tyr Pro Gly Gln Ala 
        35                  40                  45              


Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly 
    50                  55                  60                  


Gln Ala Pro Pro Ser Ala Tyr Pro Gly Pro Thr Ala Pro Gly Ala Tyr 
65                  70                  75                  80  


Pro Gly Pro Thr Ala Pro Gly Ala Tyr Pro Gly Gln Pro Ala Pro Gly 
                85                  90                  95      


Ala Phe Pro Gly Gln Pro Gly Ala Pro Gly Ala Tyr Pro Gln Cys Ser 
            100                 105                 110         


Gly Gly Tyr Pro Ala Ala Gly Pro Tyr Gly Val Pro Ala Gly Pro Leu 
        115                 120                 125             


Thr Val Pro Tyr Asp Leu Pro Leu Pro Gly Gly Val Met Pro Arg Met 
    130                 135                 140                 


Leu Ile Thr Ile Met Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Val 
145                 150                 155                 160 


Leu Asp Phe Arg Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg 
                165                 170                 175     


Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Gln Asp 
            180                 185                 190         


Asn Asn Trp Gly Lys Glu Glu Arg Gln Ser Ala Phe Pro Phe Glu Ser 
        195                 200                 205             


Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Ala Asp His Phe Lys 
    210                 215                 220                 


Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Met Lys 
225                 230                 235                 240 


Asn Leu Arg Glu Ile Ser Gln Leu Gly Ile Ser Gly Asp Ile Thr Leu 
                245                 250                 255     


Thr Ser Ala Asn His Ala Met Ile Ile Ile Gln Ala Asp Gly Trp Met 
            260                 265                 270         


Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly 
        275                 280                 285             


Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu 
    290                 295                 300                 


Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn 
305                 310                 315                 320 


Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala 
                325                 330                 335     


Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu 
            340                 345                 350         


Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser 
        355                 360                 365             


Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp 
    370                 375                 380                 


Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser 
385                 390                 395                 400 


Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile 
                405                 410                 415     


Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly 
            420                 425                 430         


Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe 
        435                 440                 445             


Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu 
    450                 455                 460                 


Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile 
465                 470                 475                 480 


Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
                485                 490                 495     


Asn Arg Leu Gly Lys 
            500     


<210> 122
<211> 678
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 122
Met Gly Glu Asp Leu Leu Leu Gly Phe Leu Leu Leu Gly Leu Leu Trp 
1               5                   10                  15      


Glu Ala Pro Val Val Ser Ser Gly Pro Gly Lys Glu Leu Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Val His Leu Pro Cys Ser Leu Lys Ser 
        35                  40                  45              


Pro Asn Leu Asp Pro Asn Phe Leu Arg Arg Gly Gly Val Ile Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Gln Pro Thr Pro Ile Pro Ala Leu Asp Leu 
65                  70                  75                  80  


His Gln Gly Met Pro Ser Pro Arg Gln Pro Ala Pro Gly Arg Tyr Thr 
                85                  90                  95      


Val Leu Ser Val Ala Pro Gly Gly Leu Arg Ser Gly Arg Gln Pro Leu 
            100                 105                 110         


His Pro His Val Gln Leu Glu Glu Arg Gly Leu Gln Arg Gly Asp Phe 
        115                 120                 125             


Ser Leu Trp Leu Arg Pro Ala Leu Arg Thr Asp Ala Gly Glu Tyr His 
    130                 135                 140                 


Ala Thr Val Arg Leu Pro Asn Arg Ala Leu Ser Cys Ser Leu Arg Leu 
145                 150                 155                 160 


Arg Val Gly Gln Ala Ser Met Ile Ala Ser Pro Ser Gly Val Leu Lys 
                165                 170                 175     


Leu Ser Asp Trp Val Leu Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg 
            180                 185                 190         


Pro Val Ser Val His Trp Phe Gln Gly Gln Asn Arg Val Pro Val Tyr 
        195                 200                 205             


Asn Ser Pro Arg His Phe Leu Ala Glu Thr Phe Leu Leu Leu Pro Gln 
    210                 215                 220                 


Val Ser Pro Leu Asp Ser Gly Thr Trp Gly Cys Val Leu Thr Tyr Arg 
225                 230                 235                 240 


Asp Gly Phe Asn Val Ser Ile Thr Tyr Asn Leu Lys Val Leu Gly Leu 
                245                 250                 255     


Glu Pro Val Ala Pro Leu Thr Val Tyr Ala Ala Glu Gly Ser Arg Val 
            260                 265                 270         


Glu Leu Pro Cys His Leu Pro Pro Gly Val Gly Thr Pro Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Glu Leu Pro Val Ala 
    290                 295                 300                 


Gly Lys Ser Gly Asn Phe Thr Leu His Leu Glu Ala Val Gly Leu Ala 
305                 310                 315                 320 


Gln Ala Gly Thr Tyr Thr Cys Ser Ile His Leu Gln Gly Gln Gln Leu 
                325                 330                 335     


Asn Ala Thr Val Thr Leu Ala Val Ile Thr Val Thr Pro Lys Ser Phe 
            340                 345                 350         


Gly Leu Pro Gly Ser Arg Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
        355                 360                 365             


Ser Gly Lys Glu Arg Phe Val Trp Arg Pro Leu Asn Asn Leu Ser Arg 
    370                 375                 380                 


Ser Cys Pro Gly Pro Val Leu Glu Ile Gln Glu Ala Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Arg Trp Gln Cys Gln Leu Tyr Glu Gly Gln Arg Leu Leu Gly Ala 
                405                 410                 415     


Thr Val Tyr Ala Ala Glu Ser Ser Ser Gly Ala His Ser Ala Arg Arg 
            420                 425                 430         


Ile Ser Gly Asp Leu Lys Gly Gly Asp Ile Ile Gln Ala Asp Gly Trp 
        435                 440                 445             


Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr 
    450                 455                 460                 


Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val 
465                 470                 475                 480 


Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu 
                485                 490                 495     


Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp 
            500                 505                 510         


Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp 
        515                 520                 525             


Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys 
    530                 535                 540                 


Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser 
545                 550                 555                 560 


Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp 
                565                 570                 575     


Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His 
            580                 585                 590         


Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe 
        595                 600                 605             


Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp 
    610                 615                 620                 


Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly 
625                 630                 635                 640 


Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys 
                645                 650                 655     


Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu 
            660                 665                 670         


Met Asn Arg Leu Gly Lys 
        675             


<210> 123
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 123
Met Gly Lys Ile Tyr Ser Phe Val Leu Val Ala Ile Ala Leu Met Met 
1               5                   10                  15      


Gly Arg Glu Gly Trp Ala Leu Glu Ser Glu Ser Cys Leu Arg Glu Gln 
            20                  25                  30          


Val Arg Leu Arg Ala Gln Val His Gln Leu Glu Thr Arg Val Lys Gln 
        35                  40                  45              


Gln Gln Thr Met Ile Ala Gln Leu Leu His Glu Lys Glu Val Gln Phe 
    50                  55                  60                  


Leu Asp Lys Gly Ser Glu Asn Ser Phe Ile Asp Leu Gly Gly Lys Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Cys Ser Glu Ile Tyr Asn Asp Gly Phe Lys Gln Ser 
                85                  90                  95      


Gly Phe Tyr Lys Ile Lys Pro Leu Gln Ser Leu Ala Glu Phe Ser Val 
            100                 105                 110         


Tyr Cys Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg 
        115                 120                 125             


Ser Asp Gly Ser Glu Asn Phe Asn Arg Gly Trp Asn Asp Tyr Glu Asn 
    130                 135                 140                 


Gly Phe Gly Asn Phe Val Gln Asn Asn Gly Glu Tyr Trp Leu Gly Asn 
145                 150                 155                 160 


Lys Asn Ile Asn Leu Leu Thr Ile Gln Gly Asp Tyr Thr Leu Lys Ile 
                165                 170                 175     


Asp Leu Thr Asp Phe Glu Lys Asn Ser Ser Phe Ala Gln Tyr Gln Ser 
            180                 185                 190         


Phe Lys Val Gly Asp Lys Lys Ser Phe Tyr Glu Leu Asn Ile Gly Glu 
        195                 200                 205             


Tyr Ser Gly Thr Ala Gly Asp Ser Leu Ser Gly Thr Phe His Pro Glu 
    210                 215                 220                 


Val Gln Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp 
225                 230                 235                 240 


Arg Asp Asn Asp Asn Tyr Gln Gly Asn Cys Ala Glu Glu Glu Gln Ser 
                245                 250                 255     


Gly Trp Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr 
            260                 265                 270         


Tyr Arg Gly Ser Tyr Arg Ala Glu Thr Asp Asn Gly Val Val Trp Tyr 
        275                 280                 285             


Thr Trp His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile 
    290                 295                 300                 


Arg Pro Ser Asp Phe Ile Pro Asn Ile Ile Ile Ile Gln Ala Asp Gly 
305                 310                 315                 320 


Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp 
                325                 330                 335     


Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser 
            340                 345                 350         


Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp 
        355                 360                 365             


Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr 
    370                 375                 380                 


Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val 
385                 390                 395                 400 


Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys 
                405                 410                 415     


Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His 
            420                 425                 430         


Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu 
        435                 440                 445             


Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro 
    450                 455                 460                 


His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe 
465                 470                 475                 480 


Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly 
                485                 490                 495     


Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile 
            500                 505                 510         


Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu 
        515                 520                 525             


Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile 
    530                 535                 540                 


Glu Met Asn Arg Leu Gly Lys 
545                 550     


<210> 124
<211> 445
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 124
Met Glu Pro Leu Pro Gly Trp Gly Ser Ala Pro Trp Ser Gln Ala Pro 
1               5                   10                  15      


Thr Asp Asn Thr Phe Arg Leu Val Pro Cys Val Phe Leu Leu Asn Leu 
            20                  25                  30          


Leu Gln Arg Ile Ser Ala Gln Pro Ser Cys Arg Gln Glu Glu Phe Leu 
        35                  40                  45              


Val Gly Asp Glu Cys Cys Pro Met Cys Asn Pro Gly Tyr His Val Lys 
    50                  55                  60                  


Gln Val Cys Ser Glu His Thr Gly Thr Val Cys Ala Pro Cys Pro Pro 
65                  70                  75                  80  


Gln Thr Tyr Thr Ala His Ala Asn Gly Leu Ser Lys Cys Leu Pro Cys 
                85                  90                  95      


Gly Val Cys Asp Pro Asp Met Gly Leu Leu Thr Trp Gln Glu Cys Ser 
            100                 105                 110         


Ser Trp Lys Asp Thr Val Cys Arg Cys Ile Pro Gly Tyr Phe Cys Glu 
        115                 120                 125             


Asn Gln Asp Gly Ser His Cys Ser Thr Cys Leu Gln His Thr Thr Cys 
    130                 135                 140                 


Pro Pro Gly Gln Arg Val Glu Lys Arg Gly Thr His Asp Gln Asp Thr 
145                 150                 155                 160 


Val Cys Ala Asp Cys Leu Thr Gly Thr Phe Ser Leu Gly Gly Thr Gln 
                165                 170                 175     


Glu Glu Cys Leu Pro Trp Thr Asn Cys Ser Ala Phe Gln Gln Glu Val 
            180                 185                 190         


Arg Arg Gly Thr Asn Ser Thr Asp Thr Thr Cys Ser Ser Gln Val Asp 
        195                 200                 205             


Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr 
    210                 215                 220                 


Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile 
225                 230                 235                 240 


Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln 
                245                 250                 255     


Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys 
            260                 265                 270         


Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr 
        275                 280                 285             


Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser 
    290                 295                 300                 


Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His 
305                 310                 315                 320 


Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp 
                325                 330                 335     


Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala 
            340                 345                 350         


Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro 
        355                 360                 365             


Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro 
    370                 375                 380                 


Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala 
385                 390                 395                 400 


Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu 
                405                 410                 415     


Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 
            420                 425                 430         


Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        435                 440                 445 


<210> 125
<211> 419
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 125
Met Lys Thr Val Pro Ala Met Leu Gly Thr Pro Arg Leu Phe Arg Glu 
1               5                   10                  15      


Phe Phe Ile Leu His Leu Gly Leu Trp Ser Ile Leu Cys Glu Lys Ala 
            20                  25                  30          


Thr Lys Arg Asn Asp Glu Glu Cys Pro Val Gln Leu Thr Ile Thr Arg 
        35                  40                  45              


Asn Ser Lys Gln Ser Ala Arg Thr Gly Glu Leu Phe Lys Ile Gln Cys 
    50                  55                  60                  


Pro Val Lys Tyr Cys Val His Arg Pro Asn Val Thr Trp Cys Lys His 
65                  70                  75                  80  


Asn Gly Thr Ile Cys Val Pro Leu Glu Val Ser Pro Gln Leu Tyr Thr 
                85                  90                  95      


Ser Trp Glu Glu Asn Gln Ser Val Pro Val Phe Val Leu His Phe Lys 
            100                 105                 110         


Pro Ile His Leu Ser Asp Asn Gly Ser Tyr Ser Cys Ser Thr Asn Phe 
        115                 120                 125             


Asn Ser Gln Val Ile Asn Ser His Ser Val Thr Ile His Val Thr Glu 
    130                 135                 140                 


Arg Thr Gln Asn Ser Ser Glu His Pro Leu Ile Thr Val Ser Asp Ile 
145                 150                 155                 160 


Pro Asp Ala Thr Asn Ala Ser Gly Pro Ser Thr Met Glu Glu Arg Pro 
                165                 170                 175     


Gly Arg Thr Trp Leu Asp Ile Ile Gln Ala Asp Gly Trp Met Cys His 
            180                 185                 190         


Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
        195                 200                 205             


Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys 
    210                 215                 220                 


Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly 
225                 230                 235                 240 


Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala 
                245                 250                 255     


Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr 
            260                 265                 270         


Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr 
        275                 280                 285             


Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys 
    290                 295                 300                 


Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu 
305                 310                 315                 320 


His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp 
                325                 330                 335     


Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr 
            340                 345                 350         


Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser 
        355                 360                 365             


Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile 
    370                 375                 380                 


Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu 
385                 390                 395                 400 


Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg 
                405                 410                 415     


Leu Gly Lys 
            


<210> 126
<211> 425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 126
Met Glu Arg Ile Leu Met Ala Pro Gly Gln Ser Cys Cys Ala Leu Ala 
1               5                   10                  15      


Ile Leu Leu Ala Ile Val Asn Phe Gln His Gly Gly Cys Ile His Val 
            20                  25                  30          


Thr Ser Ser Ala Ser Gln Lys Gly Gly Arg Leu Asp Leu Thr Cys Thr 
        35                  40                  45              


Leu Trp His Lys Lys Asp Glu Ala Glu Gly Leu Ile Leu Phe Trp Cys 
    50                  55                  60                  


Lys Asp Asn Pro Trp Asn Cys Ser Pro Glu Thr Asn Leu Glu Gln Leu 
65                  70                  75                  80  


Arg Val Lys Arg Asp Pro Glu Thr Asp Gly Ile Thr Glu Lys Ser Ser 
                85                  90                  95      


Gln Leu Val Phe Thr Ile Glu Gln Ala Thr Pro Ser Asp Ser Gly Thr 
            100                 105                 110         


Tyr Gln Cys Cys Ala Arg Ser Gln Lys Pro Glu Ile Tyr Ile His Gly 
        115                 120                 125             


His Phe Leu Ser Val Leu Val Thr Gly Asn His Thr Glu Ile Arg Gln 
    130                 135                 140                 


Arg Gln Arg Ser His Pro Asp Phe Ser His Ile Asn Gly Thr Leu Ser 
145                 150                 155                 160 


Ser Gly Phe Leu Gln Val Lys Ala Trp Gly Met Leu Val Thr Ser Leu 
                165                 170                 175     


Val Ala Leu Gln Ala Leu Tyr Thr Leu Ala Ala Asp Ile Ile Gln Ala 
            180                 185                 190         


Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe 
        195                 200                 205             


Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr 
    210                 215                 220                 


Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly 
225                 230                 235                 240 


Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr 
                245                 250                 255     


Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val 
            260                 265                 270         


Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn 
        275                 280                 285             


Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr 
    290                 295                 300                 


Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly 
305                 310                 315                 320 


Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu 
                325                 330                 335     


His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser 
            340                 345                 350         


Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val 
        355                 360                 365             


Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe 
    370                 375                 380                 


Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile 
385                 390                 395                 400 


His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
                405                 410                 415     


Asp Ile Glu Met Asn Arg Leu Gly Lys 
            420                 425 


<210> 127
<211> 477
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 127
Met Cys Phe Ile Lys Gln Gly Trp Cys Leu Val Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Gly Thr Gly Phe Gln Gly His Ser Ile Pro Asp Ile Asn 
            20                  25                  30          


Ala Thr Thr Gly Ser Asn Val Thr Leu Lys Ile His Lys Asp Pro Leu 
        35                  40                  45              


Gly Pro Tyr Lys Arg Ile Thr Trp Leu His Thr Lys Asn Gln Lys Ile 
    50                  55                  60                  


Leu Glu Tyr Asn Tyr Asn Ser Thr Lys Thr Ile Phe Glu Ser Glu Phe 
65                  70                  75                  80  


Lys Gly Arg Val Tyr Leu Glu Glu Asn Asn Gly Ala Leu His Ile Ser 
                85                  90                  95      


Asn Val Arg Lys Glu Asp Lys Gly Thr Tyr Tyr Met Arg Val Leu Arg 
            100                 105                 110         


Glu Thr Glu Asn Glu Leu Lys Ile Thr Leu Glu Val Phe Asp Pro Val 
        115                 120                 125             


Pro Lys Pro Ser Ile Glu Ile Asn Lys Thr Glu Ala Ser Thr Asp Ser 
    130                 135                 140                 


Cys His Leu Arg Leu Ser Cys Glu Val Lys Asp Gln His Val Asp Tyr 
145                 150                 155                 160 


Thr Trp Tyr Glu Ser Ser Gly Pro Phe Pro Lys Lys Ser Pro Gly Tyr 
                165                 170                 175     


Val Leu Asp Leu Ile Val Thr Pro Gln Asn Lys Ser Thr Phe Tyr Thr 
            180                 185                 190         


Cys Gln Val Ser Asn Pro Val Ser Ser Lys Asn Asp Thr Val Tyr Phe 
        195                 200                 205             


Thr Leu Pro Cys Asp Leu Ala Arg Ser Ser Gly Val Cys Trp Thr Ala 
    210                 215                 220                 


Thr Trp Leu Val Val Thr Thr Leu Ile Ile His Arg Ile Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr 
                245                 250                 255     


Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile 
            260                 265                 270         


Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln 
        275                 280                 285             


Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys 
    290                 295                 300                 


Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr 
305                 310                 315                 320 


Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser 
                325                 330                 335     


Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His 
            340                 345                 350         


Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp 
        355                 360                 365             


Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala 
    370                 375                 380                 


Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro 
385                 390                 395                 400 


Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro 
                405                 410                 415     


Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala 
            420                 425                 430         


Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu 
        435                 440                 445             


Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 
    450                 455                 460                 


Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
465                 470                 475         


<210> 128
<211> 588
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 128
Met Ala Arg Ala Ala Val Leu Pro Pro Ser Arg Leu Ser Pro Thr Leu 
1               5                   10                  15      


Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gln Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Arg Val Leu Pro Glu Val Arg Gly Arg Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Thr Thr Glu Arg Val 
    50                  55                  60                  


Ser Gln Val Thr Trp Gln Arg Leu Asp Gly Thr Val Val Ala Ala Phe 
65                  70                  75                  80  


His Pro Ser Phe Gly Val Asp Phe Pro Asn Ser Gln Phe Ser Lys Asp 
                85                  90                  95      


Arg Leu Ser Phe Val Arg Ala Arg Pro Glu Thr Asn Ala Asp Leu Arg 
            100                 105                 110         


Asp Ala Thr Leu Ala Phe Arg Gly Leu Arg Val Glu Asp Glu Gly Asn 
        115                 120                 125             


Tyr Thr Cys Glu Phe Ala Thr Phe Pro Asn Gly Thr Arg Arg Gly Val 
    130                 135                 140                 


Thr Trp Leu Arg Val Ile Ala Gln Pro Glu Asn His Ala Glu Ala Gln 
145                 150                 155                 160 


Glu Val Thr Ile Gly Pro Gln Ser Val Ala Val Ala Arg Cys Val Ser 
                165                 170                 175     


Thr Gly Gly Arg Pro Pro Ala Arg Ile Thr Trp Ile Ser Ser Leu Gly 
            180                 185                 190         


Gly Glu Ala Lys Asp Thr Gln Glu Pro Gly Ile Gln Ala Gly Thr Val 
        195                 200                 205             


Thr Ile Ile Ser Arg Tyr Ser Leu Val Pro Val Gly Arg Ala Asp Gly 
    210                 215                 220                 


Val Lys Val Thr Cys Arg Val Glu His Glu Ser Phe Glu Glu Pro Ile 
225                 230                 235                 240 


Leu Leu Pro Val Thr Leu Ser Val Arg Tyr Pro Pro Glu Val Ser Ile 
                245                 250                 255     


Ser Gly Tyr Asp Asp Asn Trp Tyr Leu Gly Arg Ser Glu Ala Ile Leu 
            260                 265                 270         


Thr Cys Asp Val Arg Ser Asn Pro Glu Pro Thr Asp Tyr Asp Trp Ser 
        275                 280                 285             


Thr Thr Ser Gly Val Phe Pro Ala Ser Ala Val Ala Gln Gly Ser Gln 
    290                 295                 300                 


Leu Leu Val His Ser Val Asp Arg Met Val Asn Thr Thr Phe Ile Cys 
305                 310                 315                 320 


Thr Ala Thr Asn Ala Val Gly Thr Gly Arg Ala Glu Gln Val Ile Leu 
                325                 330                 335     


Val Arg Glu Ser Pro Ser Thr Ala Gly Ala Gly Ala Thr Gly Gly Ile 
            340                 345                 350         


Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
        355                 360                 365             


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
    370                 375                 380                 


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
385                 390                 395                 400 


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
                405                 410                 415     


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
            420                 425                 430         


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
        435                 440                 445             


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
    450                 455                 460                 


Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser 
465                 470                 475                 480 


Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln 
                485                 490                 495     


Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp 
            500                 505                 510         


Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile 
        515                 520                 525             


Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser 
    530                 535                 540                 


Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg 
545                 550                 555                 560 


Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln 
                565                 570                 575     


Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            580                 585             


<210> 129
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 129
Met Lys Gly Trp Leu Leu Leu Val Trp Val Gln Gly Leu Ile Gln Ala 
1               5                   10                  15      


Ala Phe Leu Ala Thr Gly Ala Thr Ala Gly Thr Ile Asp Thr Lys Arg 
            20                  25                  30          


Asn Ile Ser Ala Glu Glu Gly Gly Ser Val Ile Leu Gln Cys His Phe 
        35                  40                  45              


Ser Ser Asp Thr Ala Glu Val Thr Gln Val Asp Trp Lys Gln Gln Asp 
    50                  55                  60                  


Gln Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly Trp His Val Ala Ser 
65                  70                  75                  80  


Val Phe Ser Asp Arg Val Val Pro Gly Pro Ser Leu Gly Leu Thr Phe 
                85                  90                  95      


Gln Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr Phe Cys Thr Tyr His 
            100                 105                 110         


Thr Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile Phe Leu Lys Val Gln 
        115                 120                 125             


Glu Ser Ser Val Ala Gln Phe Gln Thr Ala Pro Asp Ile Ile Gln Ala 
    130                 135                 140                 


Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe 
145                 150                 155                 160 


Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr 
                165                 170                 175     


Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly 
            180                 185                 190         


Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr 
        195                 200                 205             


Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val 
    210                 215                 220                 


Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn 
225                 230                 235                 240 


Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr 
                245                 250                 255     


Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly 
            260                 265                 270         


Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu 
        275                 280                 285             


His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser 
    290                 295                 300                 


Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val 
305                 310                 315                 320 


Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe 
                325                 330                 335     


Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile 
            340                 345                 350         


His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
        355                 360                 365             


Asp Ile Glu Met Asn Arg Leu Gly Lys 
    370                 375         


<210> 130
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 130
Met Ala Gln Leu Ala Arg Ala Thr Arg Ser Pro Leu Ser Trp Leu Leu 
1               5                   10                  15      


Leu Leu Phe Cys Tyr Ala Leu Arg Lys Ala Gly Gly Asp Ile Arg Val 
            20                  25                  30          


Leu Val Pro Tyr Asn Ser Thr Gly Val Leu Gly Gly Ser Thr Thr Leu 
        35                  40                  45              


His Cys Ser Leu Thr Ser Asn Glu Asn Val Thr Ile Thr Gln Ile Thr 
    50                  55                  60                  


Trp Met Lys Lys Asp Ser Gly Gly Ser His Ala Leu Val Ala Val Phe 
65                  70                  75                  80  


His Pro Lys Lys Gly Pro Asn Ile Lys Glu Pro Glu Arg Val Lys Phe 
                85                  90                  95      


Leu Ala Ala Gln Gln Asp Leu Arg Asn Ala Ser Leu Ala Ile Ser Asn 
            100                 105                 110         


Leu Ser Val Glu Asp Glu Gly Ile Tyr Glu Cys Gln Ile Ala Thr Phe 
        115                 120                 125             


Pro Arg Gly Ser Arg Ser Thr Asn Ala Trp Leu Lys Val Gln Ala Arg 
    130                 135                 140                 


Pro Lys Asn Thr Ala Glu Ala Leu Glu Pro Ser Pro Thr Leu Ile Leu 
145                 150                 155                 160 


Gln Asp Val Ala Lys Cys Ile Ser Ala Asn Gly His Pro Pro Gly Arg 
                165                 170                 175     


Ile Ser Trp Pro Ser Asn Val Asn Gly Ser His Arg Glu Met Lys Glu 
            180                 185                 190         


Pro Gly Ser Gln Pro Gly Thr Thr Thr Val Thr Ser Tyr Leu Ser Met 
        195                 200                 205             


Val Pro Ser Arg Gln Ala Asp Gly Lys Asn Ile Thr Cys Thr Val Glu 
    210                 215                 220                 


His Glu Ser Leu Gln Glu Leu Asp Gln Leu Leu Val Thr Leu Ser Gln 
225                 230                 235                 240 


Pro Tyr Pro Pro Glu Asn Val Ser Ile Ser Gly Tyr Asp Gly Asn Trp 
                245                 250                 255     


Tyr Val Gly Leu Thr Asn Leu Thr Leu Thr Cys Glu Ala His Ser Lys 
            260                 265                 270         


Pro Ala Pro Asp Met Ala Gly Tyr Asn Trp Ser Thr Thr Thr Gly Asp 
        275                 280                 285             


Phe Pro Asn Ser Val Lys Arg Gln Gly Asn Met Leu Leu Ile Ser Thr 
    290                 295                 300                 


Val Glu Asp Gly Leu Asn Asn Thr Val Ile Val Cys Glu Val Thr Asn 
305                 310                 315                 320 


Ala Leu Gly Ser Gly Gln Gly Gln Val His Ile Ile Val Lys Glu Lys 
                325                 330                 335     


Pro Glu Asn Met Gln Gln Asn Thr Arg Leu His Leu Ile Ile Gln Ala 
            340                 345                 350         


Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe 
        355                 360                 365             


Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr 
    370                 375                 380                 


Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly 
385                 390                 395                 400 


Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr 
                405                 410                 415     


Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val 
            420                 425                 430         


Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn 
        435                 440                 445             


Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr 
    450                 455                 460                 


Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly 
465                 470                 475                 480 


Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu 
                485                 490                 495     


His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser 
            500                 505                 510         


Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val 
        515                 520                 525             


Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe 
    530                 535                 540                 


Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile 
545                 550                 555                 560 


His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
                565                 570                 575     


Asp Ile Glu Met Asn Arg Leu Gly Lys 
            580                 585 


<210> 131
<211> 439
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 131
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Asp Ile Ile Gln Ala Asp Gly 
        195                 200                 205             


Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp 
    210                 215                 220                 


Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser 
225                 230                 235                 240 


Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp 
                245                 250                 255     


Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr 
            260                 265                 270         


Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val 
        275                 280                 285             


Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys 
    290                 295                 300                 


Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His 
305                 310                 315                 320 


Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu 
                325                 330                 335     


Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro 
            340                 345                 350         


His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe 
        355                 360                 365             


Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly 
    370                 375                 380                 


Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile 
385                 390                 395                 400 


Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu 
                405                 410                 415     


Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile 
            420                 425                 430         


Glu Met Asn Arg Leu Gly Lys 
        435                 


<210> 132
<211> 665
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 132
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ile Ile Gln Ala 
            420                 425                 430         


Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe 
        435                 440                 445             


Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr 
    450                 455                 460                 


Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly 
465                 470                 475                 480 


Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr 
                485                 490                 495     


Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val 
            500                 505                 510         


Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn 
        515                 520                 525             


Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr 
    530                 535                 540                 


Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly 
545                 550                 555                 560 


Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu 
                565                 570                 575     


His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser 
            580                 585                 590         


Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val 
        595                 600                 605             


Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe 
    610                 615                 620                 


Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile 
625                 630                 635                 640 


His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
                645                 650                 655     


Asp Ile Glu Met Asn Arg Leu Gly Lys 
            660                 665 


<210> 133
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 133
Met Asp Pro Arg Cys Thr Met Gly Leu Ala Ile Leu Ile Phe Val Thr 
1               5                   10                  15      


Val Leu Leu Ile Ser Asp Ala Val Ser Val Glu Thr Gln Ala Tyr Phe 
            20                  25                  30          


Asn Gly Thr Ala Tyr Leu Pro Cys Pro Phe Thr Lys Ala Gln Asn Ile 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Gln Lys Leu Val 
    50                  55                  60                  


Leu Tyr Glu His Tyr Leu Gly Thr Glu Lys Leu Asp Ser Val Asn Ala 
65                  70                  75                  80  


Lys Tyr Leu Gly Arg Thr Ser Phe Asp Arg Asn Asn Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Val Gln Ile Lys Asp Met Gly Ser Tyr Asp Cys Phe Ile 
            100                 105                 110         


Gln Lys Lys Pro Pro Thr Gly Ser Ile Ile Leu Gln Gln Thr Leu Thr 
        115                 120                 125             


Glu Leu Ser Val Ile Ala Asn Phe Ser Glu Pro Glu Ile Lys Leu Ala 
    130                 135                 140                 


Gln Asn Val Thr Gly Asn Ser Gly Ile Asn Leu Thr Cys Thr Ser Lys 
145                 150                 155                 160 


Gln Gly His Pro Lys Pro Lys Lys Met Tyr Phe Leu Ile Thr Asn Ser 
                165                 170                 175     


Thr Asn Glu Tyr Gly Asp Asn Met Gln Ile Ser Gln Asp Asn Val Thr 
            180                 185                 190         


Glu Leu Phe Ser Ile Ser Asn Ser Leu Ser Leu Ser Phe Pro Asp Gly 
        195                 200                 205             


Val Trp His Met Thr Val Val Cys Val Leu Glu Thr Glu Ser Met Lys 
    210                 215                 220                 


Ile Ser Ser Lys Pro Leu Asn Phe Thr Gln Glu Phe Pro Ser Pro Gln 
225                 230                 235                 240 


Thr Tyr Trp Lys Glu Asp Ile Ile Gln Ala Asp Gly Trp Met Cys His 
                245                 250                 255     


Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
            260                 265                 270         


Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys 
        275                 280                 285             


Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly 
    290                 295                 300                 


Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala 
305                 310                 315                 320 


Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr 
                325                 330                 335     


Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr 
            340                 345                 350         


Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys 
        355                 360                 365             


Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu 
    370                 375                 380                 


His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp 
385                 390                 395                 400 


Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr 
                405                 410                 415     


Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser 
            420                 425                 430         


Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile 
        435                 440                 445             


Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu 
    450                 455                 460                 


Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg 
465                 470                 475                 480 


Leu Gly Lys 
            


<210> 134
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 134
Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Asp Ile Ile Gln Ala Asp Gly Trp Met 
                245                 250                 255     


Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly 
            260                 265                 270         


Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu 
        275                 280                 285             


Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn 
    290                 295                 300                 


Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala 
305                 310                 315                 320 


Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu 
                325                 330                 335     


Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser 
            340                 345                 350         


Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp 
        355                 360                 365             


Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser 
    370                 375                 380                 


Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile 
385                 390                 395                 400 


Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly 
                405                 410                 415     


Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe 
            420                 425                 430         


Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu 
        435                 440                 445             


Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile 
    450                 455                 460                 


Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
465                 470                 475                 480 


Asn Arg Leu Gly Lys 
                485 


<210> 135
<211> 486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 135
Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn Thr Leu Asp Ile Ile Gln Ala Asp Gly Trp 
                245                 250                 255     


Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr 
            260                 265                 270         


Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val 
        275                 280                 285             


Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu 
    290                 295                 300                 


Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp 
305                 310                 315                 320 


Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp 
                325                 330                 335     


Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys 
            340                 345                 350         


Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser 
        355                 360                 365             


Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp 
    370                 375                 380                 


Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His 
385                 390                 395                 400 


Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe 
                405                 410                 415     


Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp 
            420                 425                 430         


Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly 
        435                 440                 445             


Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys 
    450                 455                 460                 


Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu 
465                 470                 475                 480 


Met Asn Arg Leu Gly Lys 
                485     


<210> 136
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 136
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Asp Ile Ile Gln Ala Asp Gly Trp Met Cys 
                245                 250                 255     


His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
            260                 265                 270         


Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln 
        275                 280                 285             


Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro 
    290                 295                 300                 


Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu 
305                 310                 315                 320 


Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr 
                325                 330                 335     


Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn 
            340                 345                 350         


Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr 
        355                 360                 365             


Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp 
    370                 375                 380                 


Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln 
385                 390                 395                 400 


Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp 
                405                 410                 415     


Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser 
            420                 425                 430         


Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile 
        435                 440                 445             


Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys 
    450                 455                 460                 


Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn 
465                 470                 475                 480 


Arg Leu Gly Lys 
                


<210> 137
<211> 293
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 137
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Arg Thr Glu Pro Arg Pro Ala Leu Thr 
                85                  90                  95      


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
            100                 105                 110         


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
        115                 120                 125             


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
    130                 135                 140                 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
145                 150                 155                 160 


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
                165                 170                 175     


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
            180                 185                 190         


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
        195                 200                 205             


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
    210                 215                 220                 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
225                 230                 235                 240 


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
                245                 250                 255     


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
            260                 265                 270         


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
        275                 280                 285             


Asp Asn Pro Trp Glu 
    290             


<210> 138
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Ala Cys Pro Trp Ala Val Ser Gly Ala 
                85                  90                  95      


Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
            100                 105                 110         


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
        115                 120                 125             


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
    130                 135                 140                 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
145                 150                 155                 160 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                165                 170                 175     


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
            180                 185                 190         


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
        195                 200                 205             


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
    210                 215                 220                 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
225                 230                 235                 240 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                245                 250                 255     


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
            260                 265                 270         


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
        275                 280                 285             


Pro Arg Ser Glu 
    290         


<210> 139
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Ser Ser Ser Pro Ala Lys Asp Pro Pro 
                85                  90                  95      


Ile Gln Arg Leu Arg Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu 
            100                 105                 110         


Phe Ile Ser Ser Tyr Lys Asn Glu Tyr Gln Thr Met Glu Val Gln Asn 
        115                 120                 125             


Asn Ser Val Val Ile Lys Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys 
    130                 135                 140                 


Gly Ser Phe Phe Gln Glu Val Lys Ile Asp Leu His Phe Arg Glu Asp 
145                 150                 155                 160 


His Asn Pro Ile Ser Ile Pro Met Leu Asn Asp Gly Arg Arg Ile Val 
                165                 170                 175     


Phe Thr Val Val Ala Ser Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr 
            180                 185                 190         


Val Asn Ala Pro Asp Thr Leu Cys Glu His Leu Gln Ile Asn Asp Gly 
        195                 200                 205             


Glu Leu Ile Val Val Gln Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly 
    210                 215                 220                 


Ser Tyr His Ser Thr Val Asn Gln Val Pro Leu 
225                 230                 235 


<210> 140
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Met Val Ser His Arg Tyr Pro Arg Ile 
                85                  90                  95      


Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
            100                 105                 110         


Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn 
        115                 120                 125             


Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly 
    130                 135                 140                 


Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
145                 150                 155                 160 


Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met 
                165                 170                 175     


Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
            180                 185                 190         


Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile 
        195                 200                 205             


Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
    210                 215                 220 


<210> 141
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Leu His Gln Arg Leu Gly Asp Ile Val 
                85                  90                  95      


Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys Leu Ile Gln 
            100                 105                 110         


Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu Thr Gly Ala 
        115                 120                 125             


Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp Glu Thr Arg 
    130                 135                 140                 


Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp Gly Ala Leu 
145                 150                 155                 160 


Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys Val Gln Leu 
                165                 170                 175     


Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu Pro Ile Thr 
            180                 185                 190         


His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu Leu Glu Leu 
        195                 200                 205             


Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser Ser Arg Val 
    210                 215                 220                 


Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly 
225                 230                 235                 240 


Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val Arg Pro Arg 
                245                 250                 255     


Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
            260                 265             


<210> 142
<211> 524
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
Met Ser Ala Leu Leu Thr Ala Ala Gly Leu Leu Phe Leu Gly Met Leu 
1               5                   10                  15      


Gln Ala Phe Pro Thr Asp Arg Pro Leu Lys Thr Thr Cys Ala Gly Asp 
            20                  25                  30          


Leu Ser His Tyr Pro Gly Glu Ala Ala Arg Asn Cys Cys Tyr Gln Cys 
        35                  40                  45              


Pro Ser Gly Leu Ser Pro Thr Gln Pro Cys Pro Arg Gly Pro Ala His 
    50                  55                  60                  


Cys Arg Lys Gln Cys Ala Pro Asp Tyr Tyr Val Asn Glu Asp Gly Lys 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Leu Pro Gly Leu Val Glu Lys Ala Pro 
                85                  90                  95      


Cys Ser Gly Asn Ser Pro Arg Ile Cys Glu Cys Gln Pro Gly Met His 
            100                 105                 110         


Cys Cys Thr Pro Ala Val Asn Ser Cys Ala Arg Cys Lys Leu His Cys 
        115                 120                 125             


Ser Gly Glu Glu Val Val Lys Ser Pro Gly Thr Ala Lys Lys Asp Thr 
    130                 135                 140                 


Ile Cys Glu Leu Pro Ser Ser Gly Ser Gly Pro Asn Cys Ser Asn Pro 
145                 150                 155                 160 


Gly Asp Arg Lys Thr Leu Thr Ser His Ala Thr Pro Gln Ala Met Pro 
                165                 170                 175     


Thr Leu Glu Ser Pro Ala Asn Asp Ser Ala Arg Ser Leu Leu Pro Met 
            180                 185                 190         


Arg Val Thr Asn Leu Val Gln Glu Asp Ala Thr Glu Leu Val Lys Val 
        195                 200                 205             


Pro Glu Ser Ser Ser Ser Lys Ala Arg Glu Pro Ser Pro Asp Pro Gly 
    210                 215                 220                 


Asn Ala Glu Lys Asn Met Thr Leu Glu Leu Pro Ser Pro Gly Thr Leu 
225                 230                 235                 240 


Pro Asp Ile Ser Thr Ser Glu Asn Ser Lys Glu Pro Ala Ser Thr Ala 
                245                 250                 255     


Ser Thr Leu Ser Leu Val Val Asp Ala Trp Thr Ser Ser Arg Met Gln 
            260                 265                 270         


Pro Thr Ser Pro Leu Ser Thr Gly Thr Pro Phe Leu Asp Pro Gly Ile 
        275                 280                 285             


Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
    290                 295                 300                 


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
305                 310                 315                 320 


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
                325                 330                 335     


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
            340                 345                 350         


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
        355                 360                 365             


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
    370                 375                 380                 


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
385                 390                 395                 400 


Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser 
                405                 410                 415     


Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln 
            420                 425                 430         


Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp 
        435                 440                 445             


Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile 
    450                 455                 460                 


Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser 
465                 470                 475                 480 


Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg 
                485                 490                 495     


Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln 
            500                 505                 510         


Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        515                 520                 


<210> 143
<211> 259
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Gln Lys Lys Asp Ser Thr Pro Asn Thr 
                85                  90                  95      


Thr Glu Lys Ala Pro Leu Lys Gly Gly Asn Cys Ser Glu Asp Leu Phe 
            100                 105                 110         


Cys Thr Leu Lys Ser Thr Pro Ser Lys Lys Ser Trp Ala Tyr Leu Gln 
        115                 120                 125             


Val Ser Lys His Leu Asn Asn Thr Lys Leu Ser Trp Asn Glu Asp Gly 
    130                 135                 140                 


Thr Ile His Gly Leu Ile Tyr Gln Asp Gly Asn Leu Ile Val Gln Phe 
145                 150                 155                 160 


Pro Gly Leu Tyr Phe Ile Val Cys Gln Leu Gln Phe Leu Val Gln Cys 
                165                 170                 175     


Ser Asn His Ser Val Asp Leu Thr Leu Gln Leu Leu Ile Asn Ser Lys 
            180                 185                 190         


Ile Lys Lys Gln Thr Leu Val Thr Val Cys Glu Ser Gly Val Gln Ser 
        195                 200                 205             


Lys Asn Ile Tyr Gln Asn Leu Ser Gln Phe Leu Leu His Tyr Leu Gln 
    210                 215                 220                 


Val Asn Ser Thr Ile Ser Val Arg Val Asp Asn Phe Gln Tyr Val Asp 
225                 230                 235                 240 


Thr Asn Thr Phe Pro Leu Asp Asn Val Leu Ser Val Phe Leu Tyr Ser 
                245                 250                 255     


Ser Ser Asp 
            


<210> 144
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Met Lys Cys Lys Phe Leu Gly Ser Phe Phe Leu Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gly Lys Gly Ala Asp Cys Arg Asp Asn Glu Thr Ile Trp Gly Val Leu 
            20                  25                  30          


Gly His Gly Ile Thr Leu Asn Ile Pro Asn Phe Gln Met Thr Asp Asp 
        35                  40                  45              


Ile Asp Glu Val Arg Trp Val Arg Arg Gly Thr Leu Val Ala Glu Phe 
    50                  55                  60                  


Lys Arg Lys Lys Pro Pro Phe Leu Ile Ser Glu Thr Tyr Glu Val Leu 
65                  70                  75                  80  


Ala Asn Gly Ser Leu Lys Ile Lys Lys Pro Met Met Arg Asn Asp Ser 
                85                  90                  95      


Gly Thr Tyr Asn Val Met Val Tyr Gly Thr Asn Gly Met Thr Arg Leu 
            100                 105                 110         


Glu Lys Asp Leu Asp Val Arg Ile Leu Glu Arg Val Ser Lys Pro Met 
        115                 120                 125             


Ile His Trp Glu Cys Pro Asn Thr Thr Leu Thr Cys Ala Val Leu Gln 
    130                 135                 140                 


Gly Thr Asp Phe Glu Leu Lys Leu Tyr Gln Gly Glu Thr Leu Leu Asn 
145                 150                 155                 160 


Ser Leu Pro Gln Lys Asn Met Ser Tyr Gln Trp Thr Asn Leu Asn Ala 
                165                 170                 175     


Pro Phe Lys Cys Glu Ala Ile Asn Pro Val Ser Lys Glu Ser Lys Met 
            180                 185                 190         


Glu Val Val Asn Cys Pro Glu Lys Gly Leu Ser Phe Tyr Asp Ile Ile 
        195                 200                 205             


Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys 
    210                 215                 220                 


Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser 
225                 230                 235                 240 


Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys 
                245                 250                 255     


Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr 
            260                 265                 270         


Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His 
        275                 280                 285             


His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe 
    290                 295                 300                 


Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser 
305                 310                 315                 320 


Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn 
                325                 330                 335     


Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val 
            340                 345                 350         


Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp 
        355                 360                 365             


Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu 
    370                 375                 380                 


Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe 
385                 390                 395                 400 


Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val 
                405                 410                 415     


Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile 
            420                 425                 430         


Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        435                 440             


<210> 145
<211> 419
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 145
Met Ala Trp Pro Pro Pro Tyr Trp Leu Cys Met Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Leu Ala Pro Asn Ser Cys Pro Asp Lys His Tyr 
            20                  25                  30          


Trp Thr Gly Gly Gly Leu Cys Cys Arg Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Phe Val Lys Asp Cys Glu Gln Asp Arg Thr Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Thr Ser Phe Ser Pro Asp Tyr His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Phe Leu Ile Arg Asn Cys 
                85                  90                  95      


Thr Val Thr Ala Asn Ala Glu Cys Ser Cys Ser Lys Asn Trp Gln Cys 
            100                 105                 110         


Arg Asp Gln Glu Cys Thr Glu Cys Asp Pro Pro Leu Asn Pro Ala Leu 
        115                 120                 125             


Thr Arg Gln Pro Ser Glu Thr Pro Ser Pro Gln Pro Pro Pro Thr His 
    130                 135                 140                 


Leu Pro His Gly Thr Glu Lys Pro Ser Trp Pro Leu His Arg Gln Leu 
145                 150                 155                 160 


Pro Asn Ser Thr Val Tyr Ser Gln Arg Ser Ser His Arg Pro Leu Cys 
                165                 170                 175     


Ser Ser Asp Cys Ile Arg Ile Ile Gln Ala Asp Gly Trp Met Cys His 
            180                 185                 190         


Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
        195                 200                 205             


Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys 
    210                 215                 220                 


Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly 
225                 230                 235                 240 


Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala 
                245                 250                 255     


Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr 
            260                 265                 270         


Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr 
        275                 280                 285             


Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys 
    290                 295                 300                 


Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu 
305                 310                 315                 320 


His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp 
                325                 330                 335     


Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr 
            340                 345                 350         


Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser 
        355                 360                 365             


Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile 
    370                 375                 380                 


Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu 
385                 390                 395                 400 


Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg 
                405                 410                 415     


Leu Gly Lys 
            


<210> 146
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 146
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Ser Lys Gln Gln Gln Arg Leu Leu Glu 
                85                  90                  95      


His Pro Glu Pro His Thr Ala Glu Leu Gln Leu Asn Leu Thr Val Pro 
            100                 105                 110         


Arg Lys Asp Pro Thr Leu Arg Trp Gly Ala Gly Pro Ala Leu Gly Arg 
        115                 120                 125             


Ser Phe Thr His Gly Pro Glu Leu Glu Glu Gly His Leu Arg Ile His 
    130                 135                 140                 


Gln Asp Gly Leu Tyr Arg Leu His Ile Gln Val Thr Leu Ala Asn Cys 
145                 150                 155                 160 


Ser Ser Pro Gly Ser Thr Leu Gln His Arg Ala Thr Leu Ala Val Gly 
                165                 170                 175     


Ile Cys Ser Pro Ala Ala His Gly Ile Ser Leu Leu Arg Gly Arg Phe 
            180                 185                 190         


Gly Gln Asp Cys Thr Val Ala Leu Gln Arg Leu Thr Tyr Leu Val His 
        195                 200                 205             


Gly Asp Val Leu Cys Thr Asn Leu Thr Leu Pro Leu Leu Pro Ser Arg 
    210                 215                 220                 


Asn Ala Asp Glu Thr Phe Phe Gly Val Gln Trp Ile Cys Pro 
225                 230                 235             


<210> 147
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 147
Met Gln Leu Lys Cys Pro Cys Phe Val Ser Leu Gly Thr Arg Gln Pro 
1               5                   10                  15      


Val Trp Lys Lys Leu His Val Ser Ser Gly Phe Phe Ser Gly Leu Gly 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Ser Ser Leu Cys Ala Ala Ser Ala Glu Thr 
        35                  40                  45              


Glu Val Gly Ala Met Val Gly Ser Asn Val Val Leu Ser Cys Ile Asp 
    50                  55                  60                  


Pro His Arg Arg His Phe Asn Leu Ser Gly Leu Tyr Val Tyr Trp Gln 
65                  70                  75                  80  


Ile Glu Asn Pro Glu Val Ser Val Thr Tyr Tyr Leu Pro Tyr Lys Ser 
                85                  90                  95      


Pro Gly Ile Asn Val Asp Ser Ser Tyr Lys Asn Arg Gly His Leu Ser 
            100                 105                 110         


Leu Asp Ser Met Lys Gln Gly Asn Phe Ser Leu Tyr Leu Lys Asn Val 
        115                 120                 125             


Thr Pro Gln Asp Thr Gln Glu Phe Thr Cys Arg Val Phe Met Asn Thr 
    130                 135                 140                 


Ala Thr Glu Leu Val Lys Ile Leu Glu Glu Val Val Arg Leu Arg Val 
145                 150                 155                 160 


Ala Ala Asn Phe Ser Thr Pro Val Ile Ser Thr Ser Asp Ser Ser Asn 
                165                 170                 175     


Pro Gly Gln Glu Arg Thr Tyr Thr Cys Met Ser Lys Asn Gly Tyr Pro 
            180                 185                 190         


Glu Pro Asn Leu Tyr Trp Ile Asn Thr Thr Asp Asn Ser Leu Ile Asp 
        195                 200                 205             


Thr Ala Leu Gln Asn Asn Thr Val Tyr Leu Asn Lys Leu Gly Leu Tyr 
    210                 215                 220                 


Asp Val Ile Ser Thr Leu Arg Leu Pro Trp Thr Ser Arg Gly Asp Val 
225                 230                 235                 240 


Leu Cys Cys Val Glu Asn Val Ala Leu His Gln Asn Ile Thr Ser Ile 
                245                 250                 255     


Ser Gln Ala Glu Ser Phe Thr Gly Asn Asn Thr Lys Asn Pro Gln Glu 
            260                 265                 270         


Thr His Asn Asn Glu Leu Lys Asp Ile Ile Gln Ala Asp Gly Trp Met 
        275                 280                 285             


Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly 
    290                 295                 300                 


Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu 
305                 310                 315                 320 


Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn 
                325                 330                 335     


Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala 
            340                 345                 350         


Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu 
        355                 360                 365             


Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser 
    370                 375                 380                 


Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp 
385                 390                 395                 400 


Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser 
                405                 410                 415     


Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile 
            420                 425                 430         


Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly 
        435                 440                 445             


Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe 
    450                 455                 460                 


Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu 
465                 470                 475                 480 


Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile 
                485                 490                 495     


Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
            500                 505                 510         


Asn Arg Leu Gly Lys 
        515         


<210> 148
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 148
Met Lys Pro Tyr Phe Cys Arg Val Phe Val Phe Cys Phe Leu Ile Arg 
1               5                   10                  15      


Leu Leu Thr Gly Glu Ile Asn Gly Ser Ala Asp His Arg Met Phe Ser 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Ser Cys Lys Tyr Pro Glu Thr Val 
        35                  40                  45              


Gln Gln Leu Lys Met Arg Leu Phe Arg Glu Arg Glu Val Leu Cys Glu 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Ala Val Ser Ile Lys Asn Pro 
65                  70                  75                  80  


Met Leu Cys Leu Tyr His Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Asn Asn Pro Asp Ser Ser Gln Gly Ser Tyr Tyr Phe Cys Ser Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Gln Glu Arg Asn Leu Ser Gly Gly Tyr 
        115                 120                 125             


Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Leu Asp Ile 
    130                 135                 140                 


Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
145                 150                 155                 160 


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
                165                 170                 175     


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
            180                 185                 190         


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
        195                 200                 205             


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
    210                 215                 220                 


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
225                 230                 235                 240 


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
                245                 250                 255     


Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser 
            260                 265                 270         


Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln 
        275                 280                 285             


Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp 
    290                 295                 300                 


Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile 
305                 310                 315                 320 


Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser 
                325                 330                 335     


Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg 
            340                 345                 350         


Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln 
        355                 360                 365             


Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
    370                 375                 380 


<210> 149
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 149
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Thr Ser Leu Lys Pro Thr Ala Ile Glu 
                85                  90                  95      


Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp His Met Thr 
            100                 105                 110         


Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly Lys Leu Lys 
        115                 120                 125             


Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val Ile Pro Val 
    130                 135                 140                 


Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val Gln Ile Tyr 
145                 150                 155                 160 


Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe Gln Ile Leu 
                165                 170                 175     


Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn Ile Tyr Leu 
            180                 185                 190         


Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr Asn Thr Tyr Trp Gly 
        195                 200                 205             


Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
    210                 215                 


<210> 150
<211> 390
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 150
Met Gly Ala Trp Ala Met Leu Tyr Gly Val Ser Met Leu Cys Val Leu 
1               5                   10                  15      


Asp Leu Gly Gln Pro Ser Val Val Glu Glu Pro Gly Cys Gly Pro Gly 
            20                  25                  30          


Lys Val Gln Asn Gly Ser Gly Asn Asn Thr Arg Cys Cys Ser Leu Tyr 
        35                  40                  45              


Ala Pro Gly Lys Glu Asp Cys Pro Lys Glu Arg Cys Ile Cys Val Thr 
    50                  55                  60                  


Pro Glu Tyr His Cys Gly Asp Pro Gln Cys Lys Ile Cys Lys His Tyr 
65                  70                  75                  80  


Pro Cys Gln Pro Gly Gln Arg Val Glu Ser Gln Gly Asp Ile Val Phe 
                85                  90                  95      


Gly Phe Arg Cys Val Ala Cys Ala Met Gly Thr Phe Ser Ala Gly Arg 
            100                 105                 110         


Asp Gly His Cys Arg Leu Trp Thr Asn Cys Ser Gln Phe Gly Phe Leu 
        115                 120                 125             


Thr Met Phe Pro Gly Asn Lys Thr His Asn Ala Val Cys Ile Pro Glu 
    130                 135                 140                 


Pro Leu Pro Thr Glu Gln Tyr Gly His Ile Ile Gln Ala Asp Gly Trp 
145                 150                 155                 160 


Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr 
                165                 170                 175     


Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val 
            180                 185                 190         


Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu 
        195                 200                 205             


Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp 
    210                 215                 220                 


Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp 
225                 230                 235                 240 


Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys 
                245                 250                 255     


Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser 
            260                 265                 270         


Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp 
        275                 280                 285             


Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His 
    290                 295                 300                 


Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe 
305                 310                 315                 320 


Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp 
                325                 330                 335     


Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly 
            340                 345                 350         


Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys 
        355                 360                 365             


Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu 
    370                 375                 380                 


Met Asn Arg Leu Gly Lys 
385                 390 


<210> 151
<211> 426
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Met Gly Asn Asn Cys Tyr Asn Val Val Val Ile Val Leu Leu Leu Val 
1               5                   10                  15      


Gly Cys Glu Lys Val Gly Ala Val Gln Asn Ser Cys Asp Asn Cys Gln 
            20                  25                  30          


Pro Gly Thr Phe Cys Arg Lys Tyr Asn Pro Val Cys Lys Ser Cys Pro 
        35                  40                  45              


Pro Ser Thr Phe Ser Ser Ile Gly Gly Gln Pro Asn Cys Asn Ile Cys 
    50                  55                  60                  


Arg Val Cys Ala Gly Tyr Phe Arg Phe Lys Lys Phe Cys Ser Ser Thr 
65                  70                  75                  80  


His Asn Ala Glu Cys Glu Cys Ile Glu Gly Phe His Cys Leu Gly Pro 
                85                  90                  95      


Gln Cys Thr Arg Cys Glu Lys Asp Cys Arg Pro Gly Gln Glu Leu Thr 
            100                 105                 110         


Lys Gln Gly Cys Lys Thr Cys Ser Leu Gly Thr Phe Asn Asp Gln Asn 
        115                 120                 125             


Gly Thr Gly Val Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Arg 
    130                 135                 140                 


Ser Val Leu Lys Thr Gly Thr Thr Glu Lys Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Pro Val Val Ser Phe Ser Pro Ser Thr Thr Ile Ser Val Thr Pro Glu 
                165                 170                 175     


Gly Gly Pro Gly Gly His Ser Leu Gln Val Leu Thr Asp Ile Ile Gln 
            180                 185                 190         


Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp 
        195                 200                 205             


Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe 
    210                 215                 220                 


Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln 
225                 230                 235                 240 


Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala 
                245                 250                 255     


Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His 
            260                 265                 270         


Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile 
        275                 280                 285             


Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr 
    290                 295                 300                 


Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu 
305                 310                 315                 320 


Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe 
                325                 330                 335     


Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu 
            340                 345                 350         


Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu 
        355                 360                 365             


Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe 
    370                 375                 380                 


Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly 
385                 390                 395                 400 


Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr 
                405                 410                 415     


Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            420                 425     


<210> 152
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 152
Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Asp Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala 
    210                 215                 220                 


Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr 
225                 230                 235                 240 


Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys 
                245                 250                 255     


Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe 
            260                 265                 270         


Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val 
        275                 280                 285             


Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly 
    290                 295                 300                 


Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile 
305                 310                 315                 320 


Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val 
                325                 330                 335     


Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His 
            340                 345                 350         


Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala 
        355                 360                 365             


Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly 
    370                 375                 380                 


Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp 
385                 390                 395                 400 


Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly 
                405                 410                 415     


Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys 
            420                 425                 430         


His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu 
        435                 440                 445             


Gly Lys 
    450 


<210> 153
<211> 595
<212> PRT
<213> Homo sapiens

<400> 153
Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210> 154
<211> 498
<212> PRT
<213> Mus sp.

<400> 154
Met Ser Ala Leu Leu Thr Ala Ala Gly Leu Leu Phe Leu Gly Met Leu 
1               5                   10                  15      


Gln Ala Phe Pro Thr Asp Arg Pro Leu Lys Thr Thr Cys Ala Gly Asp 
            20                  25                  30          


Leu Ser His Tyr Pro Gly Glu Ala Ala Arg Asn Cys Cys Tyr Gln Cys 
        35                  40                  45              


Pro Ser Gly Leu Ser Pro Thr Gln Pro Cys Pro Arg Gly Pro Ala His 
    50                  55                  60                  


Cys Arg Lys Gln Cys Ala Pro Asp Tyr Tyr Val Asn Glu Asp Gly Lys 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Leu Pro Gly Leu Val Glu Lys Ala Pro 
                85                  90                  95      


Cys Ser Gly Asn Ser Pro Arg Ile Cys Glu Cys Gln Pro Gly Met His 
            100                 105                 110         


Cys Cys Thr Pro Ala Val Asn Ser Cys Ala Arg Cys Lys Leu His Cys 
        115                 120                 125             


Ser Gly Glu Glu Val Val Lys Ser Pro Gly Thr Ala Lys Lys Asp Thr 
    130                 135                 140                 


Ile Cys Glu Leu Pro Ser Ser Gly Ser Gly Pro Asn Cys Ser Asn Pro 
145                 150                 155                 160 


Gly Asp Arg Lys Thr Leu Thr Ser His Ala Thr Pro Gln Ala Met Pro 
                165                 170                 175     


Thr Leu Glu Ser Pro Ala Asn Asp Ser Ala Arg Ser Leu Leu Pro Met 
            180                 185                 190         


Arg Val Thr Asn Leu Val Gln Glu Asp Ala Thr Glu Leu Val Lys Val 
        195                 200                 205             


Pro Glu Ser Ser Ser Ser Lys Ala Arg Glu Pro Ser Pro Asp Pro Gly 
    210                 215                 220                 


Asn Ala Glu Lys Asn Met Thr Leu Glu Leu Pro Ser Pro Gly Thr Leu 
225                 230                 235                 240 


Pro Asp Ile Ser Thr Ser Glu Asn Ser Lys Glu Pro Ala Ser Thr Ala 
                245                 250                 255     


Ser Thr Leu Ser Leu Val Val Asp Ala Trp Thr Ser Ser Arg Met Gln 
            260                 265                 270         


Pro Thr Ser Pro Leu Ser Thr Gly Thr Pro Phe Leu Asp Pro Gly Pro 
        275                 280                 285             


Val Leu Phe Trp Val Ala Met Val Val Leu Leu Val Gly Ser Gly Ser 
    290                 295                 300                 


Phe Leu Leu Cys Tyr Trp Lys Ala Cys Arg Arg Arg Phe Gln Gln Lys 
305                 310                 315                 320 


Phe His Leu Asp Tyr Leu Val Gln Thr Phe Gln Pro Lys Met Glu Gln 
                325                 330                 335     


Thr Asp Ser Cys Pro Thr Glu Lys Leu Thr Gln Pro Gln Arg Ser Gly 
            340                 345                 350         


Ser Val Thr Asp Pro Ser Thr Gly His Lys Leu Ser Pro Val Ser Pro 
        355                 360                 365             


Pro Pro Ala Val Glu Thr Cys Ala Ser Val Gly Ala Thr Tyr Leu Glu 
    370                 375                 380                 


Asn Leu Pro Leu Leu Asp Asp Ser Pro Ala Gly Asn Pro Phe Ser Pro 
385                 390                 395                 400 


Arg Glu Pro Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn Arg 
                405                 410                 415     


Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly Ser 
            420                 425                 430         


Val Lys Thr Glu Val Pro Glu Gly Arg Ala Pro Ala Gly Ser Thr Glu 
        435                 440                 445             


Ser Glu Leu Glu Ala Glu Leu Glu Val Asp His Ala Pro His Tyr Pro 
    450                 455                 460                 


Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Thr Glu Val Met Phe 
465                 470                 475                 480 


Ser Val Glu Glu Gly Gly Lys Glu Asp His Gly Pro Thr Thr Val Ser 
                485                 490                 495     


Glu Lys 
        


<210> 155
<211> 261
<212> PRT
<213> Homo sapiens

<400> 155
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210> 156
<211> 260
<212> PRT
<213> Mus sp.

<400> 156
Met Ile Glu Thr Tyr Ser Gln Pro Ser Pro Arg Ser Val Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ala Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Val Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Val Glu Glu Glu Val Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys Gly Glu Gly Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Met Arg Arg Gln Phe Glu Asp Leu Val Lys 
                85                  90                  95      


Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys Glu Asn Ser Phe Glu Met 
            100                 105                 110         


Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala Ala His Val Val Ser Glu 
        115                 120                 125             


Ala Asn Ser Asn Ala Ala Ser Val Leu Gln Trp Ala Lys Lys Gly Tyr 
    130                 135                 140                 


Tyr Thr Met Lys Ser Asn Leu Val Met Leu Glu Asn Gly Lys Gln Leu 
145                 150                 155                 160 


Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val Tyr Thr Gln Val Thr Phe 
                165                 170                 175     


Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg Pro Phe Ile Val Gly Leu 
            180                 185                 190         


Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg Ile Leu Leu Lys Ala Ala 
        195                 200                 205             


Asn Thr His Ser Ser Ser Gln Leu Cys Glu Gln Gln Ser Val His Leu 
    210                 215                 220                 


Gly Gly Val Phe Glu Leu Gln Ala Gly Ala Ser Val Phe Val Asn Val 
225                 230                 235                 240 


Thr Glu Ala Ser Gln Val Ile His Arg Val Gly Phe Ser Ser Phe Gly 
                245                 250                 255     


Leu Leu Lys Leu 
            260 


<210> 157
<211> 240
<212> PRT
<213> Homo sapiens

<400> 157
Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210> 158
<211> 239
<212> PRT
<213> Mus sp.

<400> 158
Met Glu Ser Val Val Gln Pro Ser Val Phe Val Val Asp Gly Gln Thr 
1               5                   10                  15      


Asp Ile Pro Phe Arg Arg Leu Glu Gln Asn His Arg Arg Arg Arg Cys 
            20                  25                  30          


Gly Thr Val Gln Val Ser Leu Ala Leu Val Leu Leu Leu Gly Ala Gly 
        35                  40                  45              


Leu Ala Thr Gln Gly Trp Phe Leu Leu Arg Leu His Gln Arg Leu Gly 
    50                  55                  60                  


Asp Ile Val Ala His Leu Pro Asp Gly Gly Lys Gly Ser Trp Glu Lys 
65                  70                  75                  80  


Leu Ile Gln Asp Gln Arg Ser His Gln Ala Asn Pro Ala Ala His Leu 
                85                  90                  95      


Thr Gly Ala Asn Ala Ser Leu Ile Gly Ile Gly Gly Pro Leu Leu Trp 
            100                 105                 110         


Glu Thr Arg Leu Gly Leu Ala Phe Leu Arg Gly Leu Thr Tyr His Asp 
        115                 120                 125             


Gly Ala Leu Val Thr Met Glu Pro Gly Tyr Tyr Tyr Val Tyr Ser Lys 
    130                 135                 140                 


Val Gln Leu Ser Gly Val Gly Cys Pro Gln Gly Leu Ala Asn Gly Leu 
145                 150                 155                 160 


Pro Ile Thr His Gly Leu Tyr Lys Arg Thr Ser Arg Tyr Pro Lys Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Arg Arg Ser Pro Cys Gly Arg Ala Asn Ser 
            180                 185                 190         


Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His Leu 
        195                 200                 205             


Glu Ala Gly Glu Glu Val Val Val Arg Val Pro Gly Asn Arg Leu Val 
    210                 215                 220                 


Arg Pro Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 


<210> 159
<211> 234
<212> PRT
<213> Homo sapiens

<400> 159
Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210> 160
<211> 239
<212> PRT
<213> Mus sp.

<400> 160
Met Glu Pro Gly Leu Gln Gln Ala Gly Ser Cys Gly Ala Pro Ser Pro 
1               5                   10                  15      


Asp Pro Ala Met Gln Val Gln Pro Gly Ser Val Ala Ser Pro Trp Arg 
            20                  25                  30          


Ser Thr Arg Pro Trp Arg Ser Thr Ser Arg Ser Tyr Phe Tyr Leu Ser 
        35                  40                  45              


Thr Thr Ala Leu Val Cys Leu Val Val Ala Val Ala Ile Ile Leu Val 
    50                  55                  60                  


Leu Val Val Gln Lys Lys Asp Ser Thr Pro Asn Thr Thr Glu Lys Ala 
65                  70                  75                  80  


Pro Leu Lys Gly Gly Asn Cys Ser Glu Asp Leu Phe Cys Thr Leu Lys 
                85                  90                  95      


Ser Thr Pro Ser Lys Lys Ser Trp Ala Tyr Leu Gln Val Ser Lys His 
            100                 105                 110         


Leu Asn Asn Thr Lys Leu Ser Trp Asn Glu Asp Gly Thr Ile His Gly 
        115                 120                 125             


Leu Ile Tyr Gln Asp Gly Asn Leu Ile Val Gln Phe Pro Gly Leu Tyr 
    130                 135                 140                 


Phe Ile Val Cys Gln Leu Gln Phe Leu Val Gln Cys Ser Asn His Ser 
145                 150                 155                 160 


Val Asp Leu Thr Leu Gln Leu Leu Ile Asn Ser Lys Ile Lys Lys Gln 
                165                 170                 175     


Thr Leu Val Thr Val Cys Glu Ser Gly Val Gln Ser Lys Asn Ile Tyr 
            180                 185                 190         


Gln Asn Leu Ser Gln Phe Leu Leu His Tyr Leu Gln Val Asn Ser Thr 
        195                 200                 205             


Ile Ser Val Arg Val Asp Asn Phe Gln Tyr Val Asp Thr Asn Thr Phe 
    210                 215                 220                 


Pro Leu Asp Asn Val Leu Ser Val Phe Leu Tyr Ser Ser Ser Asp 
225                 230                 235                 


<210> 161
<211> 351
<212> PRT
<213> Homo sapiens

<400> 161
Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210> 162
<211> 344
<212> PRT
<213> Mus sp.

<400> 162
Met Lys Cys Lys Phe Leu Gly Ser Phe Phe Leu Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gly Lys Gly Ala Asp Cys Arg Asp Asn Glu Thr Ile Trp Gly Val Leu 
            20                  25                  30          


Gly His Gly Ile Thr Leu Asn Ile Pro Asn Phe Gln Met Thr Asp Asp 
        35                  40                  45              


Ile Asp Glu Val Arg Trp Val Arg Arg Gly Thr Leu Val Ala Glu Phe 
    50                  55                  60                  


Lys Arg Lys Lys Pro Pro Phe Leu Ile Ser Glu Thr Tyr Glu Val Leu 
65                  70                  75                  80  


Ala Asn Gly Ser Leu Lys Ile Lys Lys Pro Met Met Arg Asn Asp Ser 
                85                  90                  95      


Gly Thr Tyr Asn Val Met Val Tyr Gly Thr Asn Gly Met Thr Arg Leu 
            100                 105                 110         


Glu Lys Asp Leu Asp Val Arg Ile Leu Glu Arg Val Ser Lys Pro Met 
        115                 120                 125             


Ile His Trp Glu Cys Pro Asn Thr Thr Leu Thr Cys Ala Val Leu Gln 
    130                 135                 140                 


Gly Thr Asp Phe Glu Leu Lys Leu Tyr Gln Gly Glu Thr Leu Leu Asn 
145                 150                 155                 160 


Ser Leu Pro Gln Lys Asn Met Ser Tyr Gln Trp Thr Asn Leu Asn Ala 
                165                 170                 175     


Pro Phe Lys Cys Glu Ala Ile Asn Pro Val Ser Lys Glu Ser Lys Met 
            180                 185                 190         


Glu Val Val Asn Cys Pro Glu Lys Gly Leu Ser Phe Tyr Val Thr Val 
        195                 200                 205             


Gly Val Gly Ala Gly Gly Leu Leu Leu Val Leu Leu Val Ala Leu Phe 
    210                 215                 220                 


Ile Phe Cys Ile Cys Lys Arg Arg Lys Arg Asn Arg Arg Arg Lys Asp 
225                 230                 235                 240 


Glu Glu Leu Glu Ile Lys Ala Ser Arg Thr Ser Thr Val Glu Arg Gly 
                245                 250                 255     


Pro Lys Pro His Ser Thr Pro Ala Ala Ala Ala Gln Asn Ser Val Ala 
            260                 265                 270         


Leu Gln Ala Pro Pro Pro Pro Gly His His Leu Gln Thr Pro Gly His 
        275                 280                 285             


Arg Pro Leu Pro Pro Gly His Arg Thr Arg Glu His Gln Gln Lys Lys 
    290                 295                 300                 


Arg Pro Pro Pro Ser Gly Thr Gln Ile His Gln Gln Lys Gly Pro Pro 
305                 310                 315                 320 


Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro Cys Gly Ser Gly Asp 
                325                 330                 335     


Gly Val Ser Leu Pro Pro Pro Asn 
            340                 


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 163
Glu Gly Ser Arg Asn Gln Asp Trp Leu 
1               5                   


