                               SEQUENCE LISTING

<110> ACHELOIS BIOPHARMA, INC.
 
<120> COMPOSITIONS AND METHODS FOR MULTIVALENT SURFACE DISPLAY ON 
      ENVELOPED PARTICLES

<130> 48295-704.601

<140> PCT/US2022/029995
<141> 2022-05-19

<150> 63/191,013
<151> 2021-05-20

<160> 100   

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> PRT
<213> Vesiculovirus indiana

<400> 1
Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
1               5                   10                  15      


Val Leu Arg Val Gly Ile 
            20          


<210> 2
<211> 37
<212> PRT
<213> Vesiculovirus indiana

<400> 2
Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile 
1               5                   10                  15      


Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val 
            20                  25                  30          


Leu Arg Val Gly Ile 
        35          


<210> 3
<211> 53
<212> PRT
<213> Vesiculovirus indiana

<400> 3
Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro 
1               5                   10                  15      


Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala 
            20                  25                  30          


Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu 
        35                  40                  45              


Arg Val Gly Ile His 
    50              


<210> 4
<211> 81
<212> PRT
<213> Vesiculovirus indiana

<400> 4
Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe 
1               5                   10                  15      


Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu 
            20                  25                  30          


Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu 
        35                  40                  45              


Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe 
    50                  55                  60                  


Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly 
65                  70                  75                  80  


Ile 
    


<210> 5
<211> 25
<212> PRT
<213> Vesiculovirus indiana

<400> 5
His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
1               5                   10                  15      


Asp Ile Glu Met Asn Arg Leu Gly Lys 
            20                  25  


<210> 6
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser His Lys Ala Ile 
1               5                   10                  15      


Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys 
            20                  25                  30          


Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser 
        35                  40                  45              


Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys 
    50                  55                  60                  


Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr 
65                  70                  75                  80  


Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His 
                85                  90                  95      


His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe 
            100                 105                 110         


Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser 
        115                 120                 125             


Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn 
    130                 135                 140                 


Leu Ile Ser Met Asp Ile 
145                 150 


<210> 7
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
                85                  90                  95      


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
            100                 105                 110         


Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser 
        115                 120                 125             


Asn Leu 
    130 


<210> 8
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
                85                  90                  95      


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
            100                 105                 110         


Ser Thr Thr 
        115 


<210> 9
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
                85                  90                  95      


Phe Ile Asn Gly 
            100 


<210> 10
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
1               5                   10                  15      


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
            20                  25                  30          


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
        35                  40                  45              


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
    50                  55                  60                  


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
65                  70                  75                  80  


His His Val Leu 
                


<210> 11
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210> 12
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Gln 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
            20                  25                  30          


Arg 
    


<210> 13
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn 
1               5                   10                  15      


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu 
            20                  25                  30          


Arg 
    


<210> 14
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr 
        35                  40  


<210> 15
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Thr Gly Ile Val Ser Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile His Thr Gly Asn Gln His Gln Ser Glu Pro 
        35                  40                  45              


Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys 
    50                  55                  60                  


Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Asn 
65                  70                  75  


<210> 16
<211> 68
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg 
1               5                   10                  15      


Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn 
            20                  25                  30          


Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys 
        35                  40                  45              


Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys 
    50                  55                  60                  


Val Thr Lys Leu 
65              


<210> 17
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ile Glu Leu Leu Lys Thr Glu Val Thr Asn Pro Ala Val Leu Arg Lys 
1               5                   10                  15      


Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys 
            20                  25                  30          


Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn Phe 
        35                  40                  45              


Val Cys Arg Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys Gly 
    50                  55                  60                  


Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys Val 
65                  70                  75                  80  


Thr Lys Leu 
            


<210> 18
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Lys Leu Cys Ile Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg 
1               5                   10                  15      


Cys Pro Thr Gln Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn 
            20                  25                  30          


Phe Val Cys Arg Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys 
        35                  40                  45              


Gly Leu Phe Gly Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys Cys 
    50                  55                  60                  


Val Thr Lys Leu Glu Gly Lys Ile Val Gln Tyr Glu Asn Leu Lys Tyr 
65                  70                  75                  80  


Ser Val Ile 
            


<210> 19
<211> 59
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Glu Ala Lys Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln 
1               5                   10                  15      


Gly Glu Ala Thr Leu Val Glu Glu Gln Asp Thr Asn Phe Val Cys Arg 
            20                  25                  30          


Arg Thr Phe Val Asp Arg Gly His Gly Asn Gly Cys Gly Leu Phe Gly 
        35                  40                  45              


Lys Gly Ser Leu Ile Thr Cys Ala Lys Phe Lys 
    50                  55                  


<210> 20
<211> 251
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30          


Asn Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Ala Ile Tyr Asn Gly Tyr Asp Val Leu Asp Asn 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
                245                 250     


<210> 21
<211> 291
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
            20                  25                  30          


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
        35                  40                  45              


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
65                  70                  75                  80  


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu 
        115                 120                 125             


Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val 
    130                 135                 140                 


Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp 
145                 150                 155                 160 


Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp 
                165                 170                 175     


Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr 
            180                 185                 190         


Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser 
        195                 200                 205             


Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr 
    210                 215                 220                 


Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
225                 230                 235                 240 


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Gly Ser 
    290     


<210> 22
<211> 299
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Pro Trp Ser His Pro Ser Ala Gln Leu Gln Pro Val Gly Gly 
1               5                   10                  15      


Asp Ala Val Ser Pro Ala Leu Met Val Leu Leu Cys Leu Gly Leu Ser 
            20                  25                  30          


Leu Gly Pro Arg Thr His Val Gln Ala Gly Asn Leu Ser Lys Ala Thr 
        35                  40                  45              


Leu Trp Ala Glu Pro Gly Ser Val Ile Ser Arg Gly Asn Ser Val Thr 
    50                  55                  60                  


Ile Arg Cys Gln Gly Thr Leu Glu Ala Gln Glu Tyr Arg Leu Val Lys 
65                  70                  75                  80  


Glu Gly Ser Pro Glu Pro Trp Asp Thr Gln Asn Pro Leu Glu Pro Lys 
                85                  90                  95      


Asn Lys Ala Arg Phe Ser Ile Pro Ser Met Thr Glu His His Ala Gly 
            100                 105                 110         


Arg Tyr Arg Cys Tyr Tyr Tyr Ser Pro Ala Gly Trp Ser Glu Pro Ser 
        115                 120                 125             


Asp Pro Leu Glu Leu Val Val Thr Gly Phe Tyr Asn Lys Pro Thr Leu 
    130                 135                 140                 


Ser Ala Leu Pro Ser Pro Val Val Thr Ser Gly Glu Asn Val Thr Leu 
145                 150                 155                 160 


Gln Cys Gly Ser Arg Leu Arg Phe Asp Arg Phe Ile Leu Thr Glu Glu 
                165                 170                 175     


Gly Asp His Lys Leu Ser Trp Thr Leu Asp Ser Gln Leu Thr Pro Ser 
            180                 185                 190         


Gly Gln Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His 
        195                 200                 205             


Arg Trp Met Leu Arg Cys Tyr Gly Ser Arg Arg His Ile Leu Gln Val 
    210                 215                 220                 


Trp Ser Glu Pro Ser Asp Leu Leu Glu Ile Pro Val Ser Gly Ala Ala 
225                 230                 235                 240 


Asp Asn Leu Ser Pro Ser Gln Asn Lys Ser Asp Ser Gly Thr Ala Ser 
                245                 250                 255     


His Leu Gln Asp Tyr Ala Val Glu Asn Leu Ile Arg Met Gly Met Ala 
            260                 265                 270         


Gly Leu Ile Leu Val Val Leu Gly Ile Leu Ile Phe Gln Asp Trp His 
        275                 280                 285             


Ser Gln Arg Ser Pro Gln Ala Ala Ala Gly Arg 
    290                 295                 


<210> 23
<211> 295
<212> PRT
<213> Mus musculus

<400> 23
Met Thr Phe Val Phe Thr Ala Val Leu Cys Leu Gly Leu Asn Leu Gly 
1               5                   10                  15      


Gln Glu Thr Ser Met Ser Glu Gly Asn Pro His Lys Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Pro Gly Leu Val Val Ala Lys Gly Lys Gln Val Thr Ile Ser 
        35                  40                  45              


Cys Glu Val Thr Thr Gly Ala Arg Glu Tyr Arg Leu Tyr Lys Glu Gly 
    50                  55                  60                  


Gly Pro His Pro Trp Arg Thr Arg Asn Thr Pro Lys Thr Thr Asn Lys 
65                  70                  75                  80  


Ala Gln Phe Leu Ile Pro Ser Ile Glu Gln Arg Ser Gly Gly Ile Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Lys Thr Pro Thr Gly Trp Ser Glu His Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Ala Val Thr Gly Leu Tyr Ser Lys Pro Ser Leu Ser Thr 
        115                 120                 125             


Gln Pro Ser Asn Val Val Asn Ser Gly Glu Thr Val Thr Leu Gln Cys 
    130                 135                 140                 


Val Ser Thr Leu Gly Phe Asn Arg Phe Val Leu Thr Lys Glu Gly Glu 
145                 150                 155                 160 


Gln Lys Trp Ser Leu Ile Gln Glu Ser Glu Phe Ile Asn Ser Thr Gly 
                165                 170                 175     


Gln Phe Gln Gly Leu Phe Thr Val Gly Pro Val Thr Pro Ser Gln Arg 
            180                 185                 190         


Trp Ile Phe Arg Cys Tyr Gly Tyr His Val Asn Ser Pro Gln Val Trp 
        195                 200                 205             


Ser Glu Pro Ser Asp Leu Leu Glu Ile His Val Ser Glu Ala Asp Gln 
    210                 215                 220                 


Pro Leu Arg Pro Ser Pro Asn Ile Ser Asp Pro Lys Thr Val Ser Gln 
225                 230                 235                 240 


Pro Gln Asn Tyr Thr Met Glu Asn Leu Ile Arg Met Gly Ala Ser Ile 
                245                 250                 255     


Leu Val Leu Val Leu Leu Gly Val Leu Leu Phe Glu Ala Gln His Ser 
            260                 265                 270         


Gln Arg Gln Thr Gln His Ala Ala Gly Arg Glu Ser Ser Ala Ser Phe 
        275                 280                 285             


Met Val Ala Asp Thr Trp Glu 
    290                 295 


<210> 24
<211> 632
<212> PRT
<213> Homo sapiens

<400> 24
Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Met Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Trp Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Trp Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Arg 
        275                 280                 285             


Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Thr Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Met Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Arg 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val 
        435                 440                 445             


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
    450                 455                 460                 


Leu Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
465                 470                 475                 480 


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
                485                 490                 495     


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
            500                 505                 510         


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
        515                 520                 525             


Asp Ser Gln Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
    530                 535                 540                 


Ala Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro 
545                 550                 555                 560 


Ser Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu 
                565                 570                 575     


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln 
            580                 585                 590         


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala 
        595                 600                 605             


Thr Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser 
    610                 615                 620                 


Ile Tyr Ala Thr Leu Ala Ile His 
625                 630         


<210> 25
<211> 680
<212> PRT
<213> Mus musculus

<400> 25
Met Ser Cys Thr Phe Thr Ala Leu Leu Cys Leu Gly Leu Thr Leu Ser 
1               5                   10                  15      


Leu Trp Ile Pro Val Leu Thr Gly Ser Leu Pro Lys Pro Ile Leu Arg 
            20                  25                  30          


Val Gln Pro Asp Ser Val Val Ser Arg Arg Thr Asn Val Thr Phe Phe 
        35                  40                  45              


Cys Glu Glu Thr Ile Gly Ala Asn Glu Tyr Arg Leu Tyr Lys Asp Gly 
    50                  55                  60                  


Lys Leu Tyr Lys Thr Val Thr Lys Asn Lys Gln Lys Gln Ala Asn Lys 
65                  70                  75                  80  


Ala Glu Phe Ser Phe Ser Asn Val Asp Leu Ser Asn Ala Gly Gln Tyr 
                85                  90                  95      


Glu Cys Ser Tyr Ser Thr Gln Asp Glu Ser Ser Gly Tyr Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Val Thr Gly His Tyr Trp Thr Pro Ser Leu Ser Ala 
        115                 120                 125             


Gln Ala Ser Pro Val Val Thr Ser Gly Gly Tyr Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Trp His Asn Asp His Lys Phe Ile Leu Thr Val Glu Gly Pro 
145                 150                 155                 160 


Gln Lys Leu Ser Trp Thr Gln Asp Ser Gln Tyr Asn Tyr Ser Thr Arg 
                165                 170                 175     


Lys Tyr His Ala Leu Phe Ser Val Gly Pro Val Thr Pro Asn Gln Arg 
            180                 185                 190         


Trp Ile Cys Arg Cys Tyr Ser Tyr Asp Arg Asn Arg Pro Tyr Val Trp 
        195                 200                 205             


Ser Pro Pro Ser Glu Ser Val Glu Leu Leu Val Ser Gly Asn Leu Gln 
    210                 215                 220                 


Lys Pro Thr Ile Lys Ala Glu Pro Gly Ser Val Ile Thr Ser Lys Arg 
225                 230                 235                 240 


Ala Met Thr Ile Trp Cys Gln Gly Asn Leu Asp Ala Glu Val Tyr Phe 
                245                 250                 255     


Leu His Asn Glu Lys Ser Gln Lys Thr Gln Ser Thr Gln Thr Leu Gln 
            260                 265                 270         


Gln Pro Gly Asn Lys Gly Arg Phe Phe Ile Pro Ser Val Thr Gln Gln 
        275                 280                 285             


His Ala Gly Gln Tyr Arg Cys Tyr Cys Tyr Ser Ser Ala Gly Trp Ser 
    290                 295                 300                 


Gln Pro Ser Asp Thr Leu Glu Leu Val Val Thr Gly Ile Tyr Glu Tyr 
305                 310                 315                 320 


Asn Glu Pro Arg Leu Ser Leu Leu Pro Ser Pro Val Val Arg Pro Gly 
                325                 330                 335     


Gly Asn Met Thr Leu His Cys Ala Ser Gln Gly His Tyr Asp Lys Phe 
            340                 345                 350         


Ile Leu Thr Lys Glu Asp Lys Lys Phe Ala Asn Ala Leu Asp Thr Glu 
        355                 360                 365             


His Ile Ser Ser Ser Arg Gln Tyr Gln Ala Leu Phe Ile Ile Gly Pro 
    370                 375                 380                 


Thr Thr Pro Thr His Thr Gly Thr Phe Arg Cys Tyr Gly Tyr Tyr Lys 
385                 390                 395                 400 


Asn Thr Pro Gln Leu Trp Ser Val Pro Ser Asn Leu Gln Gln Ile Leu 
                405                 410                 415     


Ile Ser Gly Leu Ser Lys Lys Pro Ser Leu Leu Thr His Gln Gly His 
            420                 425                 430         


Ile Leu Asp Pro Gly Met Thr Leu Thr Leu Gln Cys Phe Ser Asp Met 
        435                 440                 445             


Asn Tyr Asp Arg Phe Ala Leu His Lys Val Gly Gly Ala Asp Ile Met 
    450                 455                 460                 


Gln His Ser Ser Gln Gln Thr Asp Ile Gly Phe Ser Val Ala Asn Phe 
465                 470                 475                 480 


Thr Leu Gly Tyr Val Ser Ser Ser Thr Gly Gly Gln Tyr Arg Cys Tyr 
                485                 490                 495     


Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Ser Ser Glu Pro Leu 
            500                 505                 510         


Asp Ile Leu Ile Thr Gly Gln Leu Pro Leu Thr Pro Ser Leu Ser Val 
        515                 520                 525             


Gln Pro Asn His Thr Val His Ser Gly Glu Thr Val Ser Leu Leu Cys 
    530                 535                 540                 


Trp Ser Met Asp Ser Val Asp Thr Phe Ile Leu Ser Lys Glu Gly Ser 
545                 550                 555                 560 


Ala Gln Gln Pro Leu Arg Leu Lys Ser Lys Ser His Asp Gln Gln Ser 
                565                 570                 575     


Gln Ala Glu Phe Ser Met Ser Ala Val Thr Ser His Leu Ser Gly Thr 
            580                 585                 590         


Tyr Arg Cys Tyr Gly Ala Gln Asp Ser Ser Phe Tyr Leu Leu Ser Ser 
        595                 600                 605             


Ala Ser Ala Pro Val Glu Leu Thr Val Ser Gly Thr Ile Glu Ser Ser 
    610                 615                 620                 


Ser Trp Pro Pro Lys Arg Pro Asn Pro Pro Ile Pro Thr Glu Asn Gln 
625                 630                 635                 640 


Asp His Thr Met Glu Asn Leu Ile Arg Met Gly Met Ala Val Val Val 
                645                 650                 655     


Phe Ile Val Leu Ser Ile Leu Ala Thr Glu Ala Trp Arg Ser His Arg 
            660                 665                 670         


Gln Thr His Cys Ala Ala Gly Asn 
        675                 680 


<210> 26
<211> 285
<212> PRT
<213> Homo sapiens

<400> 26
Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210> 27
<211> 309
<212> PRT
<213> Mus musculus

<400> 27
Met Asp Glu Ser Ala Lys Thr Leu Pro Pro Pro Cys Leu Cys Phe Cys 
1               5                   10                  15      


Ser Glu Lys Gly Glu Asp Met Lys Val Gly Tyr Asp Pro Ile Thr Pro 
            20                  25                  30          


Gln Lys Glu Glu Gly Ala Trp Phe Gly Ile Cys Arg Asp Gly Arg Leu 
        35                  40                  45              


Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Ser Ser Phe Thr Ala 
    50                  55                  60                  


Met Ser Leu Tyr Gln Leu Ala Ala Leu Gln Ala Asp Leu Met Asn Leu 
65                  70                  75                  80  


Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro Ala Ala Ala 
                85                  90                  95      


Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr Pro Ala Ala 
            100                 105                 110         


Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg Arg Ala Phe 
        115                 120                 125             


Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser Ala Pro Pro 
    130                 135                 140                 


Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp Asp Asn Gly 
145                 150                 155                 160 


Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu Ile Ala Asp 
                165                 170                 175     


Ser Asp Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe Val Pro Trp 
            180                 185                 190         


Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys Glu Asn Lys 
        195                 200                 205             


Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser Gln Val Leu 
    210                 215                 220                 


Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln Arg Lys Lys 
225                 230                 235                 240 


Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
                245                 250                 255     


Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
            260                 265                 270         


Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu Ala Ile Pro 
        275                 280                 285             


Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr Phe Phe Gly 
    290                 295                 300                 


Ala Leu Lys Leu Leu 
305                 


<210> 28
<211> 184
<212> PRT
<213> Homo sapiens

<400> 28
Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210> 29
<211> 185
<212> PRT
<213> Mus musculus

<400> 29
Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 
1               5                   10                  15      


Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 
            20                  25                  30          


Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 
        35                  40                  45              


Thr Val Leu Trp Ile Phe Leu Gly Leu Thr Leu Val Leu Ser Leu Ala 
    50                  55                  60                  


Leu Phe Thr Ile Ser Phe Leu Leu Arg Lys Met Asn Pro Glu Ala Leu 
65                  70                  75                  80  


Lys Asp Glu Pro Gln Ser Pro Gly Gln Leu Asp Gly Ser Ala Gln Leu 
                85                  90                  95      


Asp Lys Ala Asp Thr Glu Leu Thr Arg Ile Arg Ala Gly Asp Asp Arg 
            100                 105                 110         


Ile Phe Pro Arg Ser Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
        115                 120                 125             


Asp Cys Val Lys Ser Lys Pro Lys Gly Asp Ser Asp His Phe Phe Pro 
    130                 135                 140                 


Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
145                 150                 155                 160 


Gly Asp Tyr Gly Lys Ser Ser Val Pro Thr Ala Leu Gln Ser Val Met 
                165                 170                 175     


Gly Met Glu Lys Pro Thr His Thr Arg 
            180                 185 


<210> 30
<211> 293
<212> PRT
<213> Homo sapiens

<400> 30
Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210> 31
<211> 249
<212> PRT
<213> Mus musculus

<400> 31
Met Ala Met Ala Phe Cys Pro Lys Asp Gln Tyr Trp Asp Ser Ser Arg 
1               5                   10                  15      


Lys Ser Cys Val Ser Cys Ala Leu Thr Cys Ser Gln Arg Ser Gln Arg 
            20                  25                  30          


Thr Cys Thr Asp Phe Cys Lys Phe Ile Asn Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Arg Tyr Tyr Asp His Leu Leu Gly Ala Cys Val Ser Cys Asp Ser Thr 
    50                  55                  60                  


Cys Thr Gln His Pro Gln Gln Cys Ala His Phe Cys Glu Lys Arg Pro 
65                  70                  75                  80  


Arg Ser Gln Ala Asn Leu Gln Pro Glu Leu Gly Arg Pro Gln Ala Gly 
                85                  90                  95      


Glu Val Glu Val Arg Ser Asp Asn Ser Gly Arg His Gln Gly Ser Glu 
            100                 105                 110         


His Gly Pro Gly Leu Arg Leu Ser Ser Asp Gln Leu Thr Leu Tyr Cys 
        115                 120                 125             


Thr Leu Gly Val Cys Leu Cys Ala Ile Phe Cys Cys Phe Leu Val Ala 
    130                 135                 140                 


Leu Ala Ser Phe Leu Arg Arg Arg Gly Glu Pro Leu Pro Ser Gln Pro 
145                 150                 155                 160 


Ala Gly Pro Arg Gly Ser Gln Ala Asn Ser Pro His Ala His Arg Pro 
                165                 170                 175     


Val Thr Glu Ala Cys Asp Glu Val Thr Ala Ser Pro Gln Pro Val Glu 
            180                 185                 190         


Thr Cys Ser Phe Cys Phe Pro Glu Arg Ser Ser Pro Thr Gln Glu Ser 
        195                 200                 205             


Ala Pro Arg Ser Leu Gly Ile His Gly Phe Ala Gly Thr Ala Ala Pro 
    210                 215                 220                 


Gln Pro Cys Met Arg Ala Thr Val Gly Gly Leu Gly Val Leu Arg Ala 
225                 230                 235                 240 


Ser Thr Gly Asp Ala Arg Pro Ala Thr 
                245                 


<210> 32
<211> 184
<212> PRT
<213> Homo sapiens

<400> 32
Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210> 33
<211> 175
<212> PRT
<213> Mus musculus

<400> 33
Met Gly Ala Arg Arg Leu Arg Val Arg Ser Gln Arg Ser Arg Asp Ser 
1               5                   10                  15      


Ser Val Pro Thr Gln Cys Asn Gln Thr Glu Cys Phe Asp Pro Leu Val 
            20                  25                  30          


Arg Asn Cys Val Ser Cys Glu Leu Phe His Thr Pro Asp Thr Gly His 
        35                  40                  45              


Thr Ser Ser Leu Glu Pro Gly Thr Ala Leu Gln Pro Gln Glu Gly Ser 
    50                  55                  60                  


Ala Leu Arg Pro Asp Val Ala Leu Leu Val Gly Ala Pro Ala Leu Leu 
65                  70                  75                  80  


Gly Leu Ile Leu Ala Leu Thr Leu Val Gly Leu Val Ser Leu Val Ser 
                85                  90                  95      


Trp Arg Trp Arg Gln Gln Leu Arg Thr Ala Ser Pro Asp Thr Ser Glu 
            100                 105                 110         


Gly Val Gln Gln Glu Ser Leu Glu Asn Val Phe Val Pro Ser Ser Glu 
        115                 120                 125             


Thr Pro His Ala Ser Ala Pro Thr Trp Pro Pro Leu Lys Glu Asp Ala 
    130                 135                 140                 


Asp Ser Ala Leu Pro Arg His Ser Val Pro Val Pro Ala Thr Glu Leu 
145                 150                 155                 160 


Gly Ser Thr Glu Leu Val Thr Thr Lys Thr Ala Gly Pro Glu Gln 
                165                 170                 175 


<210> 34
<211> 128
<212> PRT
<213> Homo sapiens

<400> 34
Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210> 35
<211> 129
<212> PRT
<213> Mus musculus

<400> 35
Met Arg Ala Gln Arg Gly Leu Ile Leu Leu Leu Leu Leu Leu Ala Val 
1               5                   10                  15      


Phe Cys Ser Thr Ala Val Ser Leu Lys Cys Tyr Asn Cys Leu Asp Pro 
            20                  25                  30          


Val Ser Ser Cys Lys Ile Asn Thr Thr Cys Ser Pro Asn Leu Asp Ser 
        35                  40                  45              


Cys Leu Tyr Ala Val Ala Gly Arg Gln Val Tyr Gln Gln Cys Trp Lys 
    50                  55                  60                  


Leu Ser Asp Cys Asn Ser Asn Tyr Ile Met Ser Arg Leu Asp Val Ala 
65                  70                  75                  80  


Gly Ile Gln Ser Lys Cys Cys Gln Trp Asp Leu Cys Asn Lys Asn Leu 
                85                  90                  95      


Asp Gly Leu Glu Glu Pro Asn Asn Ala Glu Thr Ser Ser Leu Arg Lys 
            100                 105                 110         


Thr Ala Leu Leu Gly Thr Ser Val Leu Val Ala Ile Leu Lys Phe Cys 
        115                 120                 125             


Phe 
    


<210> 36
<211> 381
<212> PRT
<213> Homo sapiens

<400> 36
Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210> 37
<211> 390
<212> PRT
<213> Mus musculus

<400> 37
Met Ile Arg Gly Arg Ala Pro Arg Thr Arg Pro Ser Pro Pro Pro Pro 
1               5                   10                  15      


Leu Leu Pro Leu Leu Ser Leu Ser Leu Leu Leu Leu Ser Pro Thr Val 
            20                  25                  30          


Arg Gly Asp Cys Gly Pro Pro Pro Asp Ile Pro Asn Ala Arg Pro Ile 
        35                  40                  45              


Leu Gly Arg His Ser Lys Phe Ala Glu Gln Ser Lys Val Ala Tyr Ser 
    50                  55                  60                  


Cys Asn Asn Gly Phe Lys Gln Val Pro Asp Lys Ser Asn Ile Val Val 
65                  70                  75                  80  


Cys Leu Glu Asn Gly Gln Trp Ser Ser His Glu Thr Phe Cys Glu Lys 
                85                  90                  95      


Ser Cys Val Ala Pro Glu Arg Leu Ser Phe Ala Ser Leu Lys Lys Glu 
            100                 105                 110         


Tyr Leu Asn Met Asn Phe Phe Pro Val Gly Thr Ile Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Phe Arg Lys Gln Pro Pro Leu Pro Gly Lys Ala Thr 
    130                 135                 140                 


Cys Leu Glu Asp Leu Val Trp Ser Pro Val Ala Gln Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Lys Asp Leu Asp Asn Gly His Ile Asn Ile 
                165                 170                 175     


Pro Thr Gly Ile Leu Phe Gly Ser Glu Ile Asn Phe Ser Cys Asn Pro 
            180                 185                 190         


Gly Tyr Arg Leu Val Gly Val Ser Ser Thr Phe Cys Ser Val Thr Gly 
        195                 200                 205             


Asn Thr Val Asp Trp Asp Asp Glu Phe Pro Val Cys Thr Glu Ile His 
    210                 215                 220                 


Cys Pro Glu Pro Pro Lys Ile Asn Asn Gly Ile Met Arg Gly Glu Ser 
225                 230                 235                 240 


Asp Ser Tyr Thr Tyr Ser Gln Val Val Thr Tyr Ser Cys Asp Lys Gly 
                245                 250                 255     


Phe Ile Leu Val Gly Asn Ala Ser Ile Tyr Cys Thr Val Ser Lys Ser 
            260                 265                 270         


Asp Val Gly Gln Trp Ser Ser Pro Pro Pro Arg Cys Ile Glu Lys Ser 
        275                 280                 285             


Lys Val Pro Thr Lys Lys Pro Thr Ile Asn Val Pro Ser Thr Gly Thr 
    290                 295                 300                 


Pro Ser Thr Pro Gln Lys Pro Thr Thr Glu Ser Val Pro Asn Pro Gly 
305                 310                 315                 320 


Asp Gln Pro Thr Pro Gln Lys Pro Ser Thr Val Lys Val Ser Ala Thr 
                325                 330                 335     


Gln His Val Pro Val Thr Lys Thr Thr Val Arg His Pro Ile Arg Thr 
            340                 345                 350         


Ser Thr Asp Lys Gly Glu Pro Asn Thr Gly Gly Asp Arg Tyr Ile Tyr 
        355                 360                 365             


Gly His Thr Cys Leu Ile Thr Leu Thr Val Leu His Val Met Leu Ser 
    370                 375                 380                 


Leu Ile Gly Tyr Leu Thr 
385                 390 


<210> 38
<211> 153
<212> PRT
<213> Homo sapiens

<400> 38
Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210> 39
<211> 140
<212> PRT
<213> Mus musculus

<400> 39
Met Gly Leu Asn Pro Gln Leu Val Val Ile Leu Leu Phe Phe Leu Glu 
1               5                   10                  15      


Cys Thr Arg Ser His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu 
            20                  25                  30          


Ile Ile Gly Ile Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr 
        35                  40                  45              


Glu Met Asp Val Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu 
    50                  55                  60                  


Ser Glu Leu Val Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys His Gly Lys Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met 
                85                  90                  95      


Glu Leu Gln Arg Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile 
            100                 105                 110         


Ser Cys Thr Met Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu 
        115                 120                 125             


Glu Ser Leu Lys Ser Ile Met Gln Met Asp Tyr Ser 
    130                 135                 140 


<210> 40
<211> 244
<212> PRT
<213> Homo sapiens

<400> 40
Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210> 41
<211> 235
<212> PRT
<213> Mus musculus

<400> 41
Met Asp Thr Glu Asn Arg Ser Arg Ala Asp Leu Ala Leu Pro Asn Pro 
1               5                   10                  15      


Gln Glu Ser Ser Ser Ala Pro Asp Ile Glu Leu Leu Glu Ala Ser Pro 
            20                  25                  30          


Ala Lys Ala Ala Pro Pro Lys Gln Thr Trp Arg Thr Phe Leu Lys Lys 
        35                  40                  45              


Glu Leu Glu Phe Leu Gly Ala Thr Gln Ile Leu Val Gly Leu Ile Cys 
    50                  55                  60                  


Leu Cys Phe Gly Thr Ile Val Cys Ser Val Leu Tyr Val Ser Asp Phe 
65                  70                  75                  80  


Asp Glu Glu Val Leu Leu Leu Tyr Lys Leu Gly Tyr Pro Phe Trp Gly 
                85                  90                  95      


Ala Val Leu Phe Val Leu Ser Gly Phe Leu Ser Ile Ile Ser Glu Arg 
            100                 105                 110         


Lys Asn Thr Leu Tyr Leu Val Arg Gly Ser Leu Gly Ala Asn Ile Val 
        115                 120                 125             


Ser Ser Ile Ala Ala Gly Thr Gly Ile Ala Met Leu Ile Leu Asn Leu 
    130                 135                 140                 


Thr Asn Asn Phe Ala Tyr Met Asn Asn Cys Lys Asn Val Thr Glu Asp 
145                 150                 155                 160 


Asp Gly Cys Phe Val Ala Ser Phe Thr Thr Glu Leu Val Leu Met Met 
                165                 170                 175     


Leu Phe Leu Thr Ile Leu Ala Phe Cys Ser Ala Val Leu Phe Thr Ile 
            180                 185                 190         


Tyr Arg Ile Gly Gln Glu Leu Glu Ser Lys Lys Val Pro Asp Asp Arg 
        195                 200                 205             


Leu Tyr Glu Glu Leu Asn Val Tyr Ser Pro Ile Tyr Ser Glu Leu Glu 
    210                 215                 220                 


Asp Lys Gly Glu Thr Ser Ser Pro Val Asp Ser 
225                 230                 235 


<210> 42
<211> 212
<212> PRT
<213> Homo sapiens

<400> 42
Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210> 43
<211> 211
<212> PRT
<213> Mus musculus

<400> 43
Met Lys Phe Leu Ser Ala Arg Asp Phe His Pro Val Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Val Thr Thr Thr Ala Phe Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr Pro Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Val Gly Gly Leu Ile Thr His Val Leu Trp Glu Ile Val Glu 
    50                  55                  60                  


Met Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Asn Asp 
65                  70                  75                  80  


Asp Ala Leu Ala Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn 
                85                  90                  95      


Asp Gly Cys Tyr Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys 
            100                 105                 110         


Ile Ser Ser Gly Leu Leu Glu Tyr His Ser Tyr Leu Glu Tyr Met Lys 
        115                 120                 125             


Asn Asn Leu Lys Asp Asn Lys Lys Asp Lys Ala Arg Val Leu Gln Arg 
    130                 135                 140                 


Asp Thr Glu Thr Leu Ile His Ile Phe Asn Gln Glu Val Lys Asp Leu 
145                 150                 155                 160 


His Lys Ile Val Leu Pro Thr Pro Ile Ser Asn Ala Leu Leu Thr Asp 
                165                 170                 175     


Lys Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Phe 
            180                 185                 190         


Ile Leu Lys Ser Leu Glu Glu Phe Leu Lys Val Thr Leu Arg Ser Thr 
        195                 200                 205             


Arg Gln Thr 
    210     


<210> 44
<211> 93
<212> PRT
<213> Homo sapiens

<400> 44
Met Asn Ala Lys Val Val Val Val Leu Val Leu Val Leu Thr Ala Leu 
1               5                   10                  15      


Cys Leu Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Val Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Phe Lys Met 
                85                  90              


<210> 45
<211> 93
<212> PRT
<213> Mus musculus

<400> 45
Met Asp Ala Lys Val Val Ala Val Leu Ala Leu Val Leu Ala Ala Leu 
1               5                   10                  15      


Cys Ile Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Ile Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Leu Lys Met 
                85                  90              


<210> 46
<211> 532
<212> PRT
<213> Homo sapiens

<400> 46
Met Ala Pro Ser Ser Pro Arg Pro Ala Leu Pro Ala Leu Leu Val Leu 
1               5                   10                  15      


Leu Gly Ala Leu Phe Pro Gly Pro Gly Asn Ala Gln Thr Ser Val Ser 
            20                  25                  30          


Pro Ser Lys Val Ile Leu Pro Arg Gly Gly Ser Val Leu Val Thr Cys 
        35                  40                  45              


Ser Thr Ser Cys Asp Gln Pro Lys Leu Leu Gly Ile Glu Thr Pro Leu 
    50                  55                  60                  


Pro Lys Lys Glu Leu Leu Leu Pro Gly Asn Asn Arg Lys Val Tyr Glu 
65                  70                  75                  80  


Leu Ser Asn Val Gln Glu Asp Ser Gln Pro Met Cys Tyr Ser Asn Cys 
                85                  90                  95      


Pro Asp Gly Gln Ser Thr Ala Lys Thr Phe Leu Thr Val Tyr Trp Thr 
            100                 105                 110         


Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Ser Trp Gln Pro Val Gly 
        115                 120                 125             


Lys Asn Leu Thr Leu Arg Cys Gln Val Glu Gly Gly Ala Pro Arg Ala 
    130                 135                 140                 


Asn Leu Thr Val Val Leu Leu Arg Gly Glu Lys Glu Leu Lys Arg Glu 
145                 150                 155                 160 


Pro Ala Val Gly Glu Pro Ala Glu Val Thr Thr Thr Val Leu Val Arg 
                165                 170                 175     


Arg Asp His His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu Asp Leu 
            180                 185                 190         


Arg Pro Gln Gly Leu Glu Leu Phe Glu Asn Thr Ser Ala Pro Tyr Gln 
        195                 200                 205             


Leu Gln Thr Phe Val Leu Pro Ala Thr Pro Pro Gln Leu Val Ser Pro 
    210                 215                 220                 


Arg Val Leu Glu Val Asp Thr Gln Gly Thr Val Val Cys Ser Leu Asp 
225                 230                 235                 240 


Gly Leu Phe Pro Val Ser Glu Ala Gln Val His Leu Ala Leu Gly Asp 
                245                 250                 255     


Gln Arg Leu Asn Pro Thr Val Thr Tyr Gly Asn Asp Ser Phe Ser Ala 
            260                 265                 270         


Lys Ala Ser Val Ser Val Thr Ala Glu Asp Glu Gly Thr Gln Arg Leu 
        275                 280                 285             


Thr Cys Ala Val Ile Leu Gly Asn Gln Ser Gln Glu Thr Leu Gln Thr 
    290                 295                 300                 


Val Thr Ile Tyr Ser Phe Pro Ala Pro Asn Val Ile Leu Thr Lys Pro 
305                 310                 315                 320 


Glu Val Ser Glu Gly Thr Glu Val Thr Val Lys Cys Glu Ala His Pro 
                325                 330                 335     


Arg Ala Lys Val Thr Leu Asn Gly Val Pro Ala Gln Pro Leu Gly Pro 
            340                 345                 350         


Arg Ala Gln Leu Leu Leu Lys Ala Thr Pro Glu Asp Asn Gly Arg Ser 
        355                 360                 365             


Phe Ser Cys Ser Ala Thr Leu Glu Val Ala Gly Gln Leu Ile His Lys 
    370                 375                 380                 


Asn Gln Thr Arg Glu Leu Arg Val Leu Tyr Gly Pro Arg Leu Asp Glu 
385                 390                 395                 400 


Arg Asp Cys Pro Gly Asn Trp Thr Trp Pro Glu Asn Ser Gln Gln Thr 
                405                 410                 415     


Pro Met Cys Gln Ala Trp Gly Asn Pro Leu Pro Glu Leu Lys Cys Leu 
            420                 425                 430         


Lys Asp Gly Thr Phe Pro Leu Pro Ile Gly Glu Ser Val Thr Val Thr 
        435                 440                 445             


Arg Asp Leu Glu Gly Thr Tyr Leu Cys Arg Ala Arg Ser Thr Gln Gly 
    450                 455                 460                 


Glu Val Thr Arg Lys Val Thr Val Asn Val Leu Ser Pro Arg Tyr Glu 
465                 470                 475                 480 


Ile Val Ile Ile Thr Val Val Ala Ala Ala Val Ile Met Gly Thr Ala 
                485                 490                 495     


Gly Leu Ser Thr Tyr Leu Tyr Asn Arg Gln Arg Lys Ile Lys Lys Tyr 
            500                 505                 510         


Arg Leu Gln Gln Ala Gln Lys Gly Thr Pro Met Lys Pro Asn Thr Gln 
        515                 520                 525             


Ala Thr Pro Pro 
    530         


<210> 47
<211> 537
<212> PRT
<213> Mus musculus

<400> 47
Met Ala Ser Thr Arg Ala Lys Pro Thr Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Thr Val Val Ile Pro Gly Pro Gly Asp Ala Gln Val Ser Ile His 
            20                  25                  30          


Pro Arg Glu Ala Phe Leu Pro Gln Gly Gly Ser Val Gln Val Asn Cys 
        35                  40                  45              


Ser Ser Ser Cys Lys Glu Asp Leu Ser Leu Gly Leu Glu Thr Gln Trp 
    50                  55                  60                  


Leu Lys Asp Glu Leu Glu Ser Gly Pro Asn Trp Lys Leu Phe Glu Leu 
65                  70                  75                  80  


Ser Glu Ile Gly Glu Asp Ser Ser Pro Leu Cys Phe Glu Asn Cys Gly 
                85                  90                  95      


Thr Val Gln Ser Ser Ala Ser Ala Thr Ile Thr Val Tyr Ser Phe Pro 
            100                 105                 110         


Glu Ser Val Glu Leu Arg Pro Leu Pro Ala Trp Gln Gln Val Gly Lys 
        115                 120                 125             


Asp Leu Thr Leu Arg Cys His Val Asp Gly Gly Ala Pro Arg Thr Gln 
    130                 135                 140                 


Leu Ser Ala Val Leu Leu Arg Gly Glu Glu Ile Leu Ser Arg Gln Pro 
145                 150                 155                 160 


Val Gly Gly His Pro Lys Asp Pro Lys Glu Ile Thr Phe Thr Val Leu 
                165                 170                 175     


Ala Ser Arg Gly Asp His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu 
            180                 185                 190         


Asp Leu Arg Pro Gln Gly Leu Ala Leu Phe Ser Asn Val Ser Glu Ala 
        195                 200                 205             


Arg Ser Leu Arg Thr Phe Asp Leu Pro Ala Thr Ile Pro Lys Leu Asp 
    210                 215                 220                 


Thr Pro Asp Leu Leu Glu Val Gly Thr Gln Gln Lys Leu Phe Cys Ser 
225                 230                 235                 240 


Leu Glu Gly Leu Phe Pro Ala Ser Glu Ala Arg Ile Tyr Leu Glu Leu 
                245                 250                 255     


Gly Gly Gln Met Pro Thr Gln Glu Ser Thr Asn Ser Ser Asp Ser Val 
            260                 265                 270         


Ser Ala Thr Ala Leu Val Glu Val Thr Glu Glu Phe Asp Arg Thr Leu 
        275                 280                 285             


Pro Leu Arg Cys Val Leu Glu Leu Ala Asp Gln Ile Leu Glu Thr Gln 
    290                 295                 300                 


Arg Thr Leu Thr Val Tyr Asn Phe Ser Ala Pro Val Leu Thr Leu Ser 
305                 310                 315                 320 


Gln Leu Glu Val Ser Glu Gly Ser Gln Val Thr Val Lys Cys Glu Ala 
                325                 330                 335     


His Ser Gly Ser Lys Val Val Leu Leu Ser Gly Val Glu Pro Arg Pro 
            340                 345                 350         


Pro Thr Pro Gln Val Gln Phe Thr Leu Asn Ala Ser Ser Glu Asp His 
        355                 360                 365             


Lys Arg Ser Phe Phe Cys Ser Ala Ala Leu Glu Val Ala Gly Lys Phe 
    370                 375                 380                 


Leu Phe Lys Asn Gln Thr Leu Glu Leu His Val Leu Tyr Gly Pro Arg 
385                 390                 395                 400 


Leu Asp Glu Thr Asp Cys Leu Gly Asn Trp Thr Trp Gln Glu Gly Ser 
                405                 410                 415     


Gln Gln Thr Leu Lys Cys Gln Ala Trp Gly Asn Pro Ser Pro Lys Met 
            420                 425                 430         


Thr Cys Arg Arg Lys Ala Asp Gly Ala Leu Leu Pro Ile Gly Val Val 
        435                 440                 445             


Lys Ser Val Lys Gln Glu Met Asn Gly Thr Tyr Val Cys His Ala Phe 
    450                 455                 460                 


Ser Ser His Gly Asn Val Thr Arg Asn Val Tyr Leu Thr Val Leu Tyr 
465                 470                 475                 480 


His Ser Gln Asn Asn Trp Thr Ile Ile Ile Leu Val Pro Val Leu Leu 
                485                 490                 495     


Val Ile Val Gly Leu Val Met Ala Ala Ser Tyr Val Tyr Asn Arg Gln 
            500                 505                 510         


Arg Lys Ile Arg Ile Tyr Lys Leu Gln Lys Ala Gln Glu Glu Ala Ile 
        515                 520                 525             


Lys Leu Lys Gly Gln Ala Pro Pro Pro 
    530                 535         


<210> 48
<211> 1086
<212> PRT
<213> Homo sapiens

<400> 48
Met Lys Asp Ser Cys Ile Thr Val Met Ala Met Ala Leu Leu Ser Gly 
1               5                   10                  15      


Phe Phe Phe Phe Ala Pro Ala Ser Ser Tyr Asn Leu Asp Val Arg Gly 
            20                  25                  30          


Ala Arg Ser Phe Ser Pro Pro Arg Ala Gly Arg His Phe Gly Tyr Arg 
        35                  40                  45              


Val Leu Gln Val Gly Asn Gly Val Ile Val Gly Ala Pro Gly Glu Gly 
    50                  55                  60                  


Asn Ser Thr Gly Ser Leu Tyr Gln Cys Gln Ser Gly Thr Gly His Cys 
65                  70                  75                  80  


Leu Pro Val Thr Leu Arg Gly Ser Asn Tyr Thr Ser Lys Tyr Leu Gly 
                85                  90                  95      


Met Thr Leu Ala Thr Asp Pro Thr Asp Gly Ser Ile Leu Phe Ala Ala 
            100                 105                 110         


Val Gln Phe Ser Thr Ser Tyr Lys Thr Glu Phe Asp Phe Ser Asp Tyr 
        115                 120                 125             


Val Lys Arg Lys Asp Pro Asp Ala Leu Leu Lys His Val Lys His Met 
    130                 135                 140                 


Leu Leu Leu Thr Asn Thr Phe Gly Ala Ile Asn Tyr Val Ala Thr Glu 
145                 150                 155                 160 


Val Phe Arg Glu Glu Leu Gly Ala Arg Pro Asp Ala Thr Lys Val Leu 
                165                 170                 175     


Ile Ile Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn Ile Asp Ala 
            180                 185                 190         


Ala Lys Asp Ile Ile Arg Tyr Ile Ile Gly Ile Gly Lys His Phe Gln 
        195                 200                 205             


Thr Lys Glu Ser Gln Glu Thr Leu His Lys Phe Ala Ser Lys Pro Ala 
    210                 215                 220                 


Ser Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp Leu 
225                 230                 235                 240 


Phe Thr Glu Leu Gln Lys Lys Ile Tyr Val Ile Glu Gly Thr Ser Lys 
                245                 250                 255     


Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile Ser 
            260                 265                 270         


Ala Asp Leu Ser Arg Gly His Ala Val Val Gly Ala Val Gly Ala Lys 
        275                 280                 285             


Asp Trp Ala Gly Gly Phe Leu Asp Leu Lys Ala Asp Leu Gln Asp Asp 
    290                 295                 300                 


Thr Phe Ile Gly Asn Glu Pro Leu Thr Pro Glu Val Arg Ala Gly Tyr 
305                 310                 315                 320 


Leu Gly Tyr Thr Val Thr Trp Leu Pro Ser Arg Gln Lys Thr Ser Leu 
                325                 330                 335     


Leu Ala Ser Gly Ala Pro Arg Tyr Gln His Met Gly Arg Val Leu Leu 
            340                 345                 350         


Phe Gln Glu Pro Gln Gly Gly Gly His Trp Ser Gln Val Gln Thr Ile 
        355                 360                 365             


His Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Gly Val 
    370                 375                 380                 


Asp Val Asp Gln Asp Gly Glu Thr Glu Leu Leu Leu Ile Gly Ala Pro 
385                 390                 395                 400 


Leu Phe Tyr Gly Glu Gln Arg Gly Gly Arg Val Phe Ile Tyr Gln Arg 
                405                 410                 415     


Arg Gln Leu Gly Phe Glu Glu Val Ser Glu Leu Gln Gly Asp Pro Gly 
            420                 425                 430         


Tyr Pro Leu Gly Arg Phe Gly Glu Ala Ile Thr Ala Leu Thr Asp Ile 
        435                 440                 445             


Asn Gly Asp Gly Leu Val Asp Val Ala Val Gly Ala Pro Leu Glu Glu 
    450                 455                 460                 


Gln Gly Ala Val Tyr Ile Phe Asn Gly Arg His Gly Gly Leu Ser Pro 
465                 470                 475                 480 


Gln Pro Ser Gln Arg Ile Glu Gly Thr Gln Val Leu Ser Gly Ile Gln 
                485                 490                 495     


Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Glu Gly Asp Gly 
            500                 505                 510         


Leu Ala Asp Val Ala Val Gly Ala Glu Ser Gln Met Ile Val Leu Ser 
        515                 520                 525             


Ser Arg Pro Val Val Asp Met Val Thr Leu Met Ser Phe Ser Pro Ala 
    530                 535                 540                 


Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Thr Ser Asn Lys 
545                 550                 555                 560 


Met Lys Glu Gly Val Asn Ile Thr Ile Cys Phe Gln Ile Lys Ser Leu 
                565                 570                 575     


Ile Pro Gln Phe Gln Gly Arg Leu Val Ala Asn Leu Thr Tyr Thr Leu 
            580                 585                 590         


Gln Leu Asp Gly His Arg Thr Arg Arg Arg Gly Leu Phe Pro Gly Gly 
        595                 600                 605             


Arg His Glu Leu Arg Arg Asn Ile Ala Val Thr Thr Ser Met Ser Cys 
    610                 615                 620                 


Thr Asp Phe Ser Phe His Phe Pro Val Cys Val Gln Asp Leu Ile Ser 
625                 630                 635                 640 


Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Trp Glu Glu Glu Gly Thr 
                645                 650                 655     


Pro Arg Asp Gln Arg Ala Gly Lys Asp Ile Pro Pro Ile Leu Arg Pro 
            660                 665                 670         


Ser Leu His Ser Glu Thr Trp Glu Ile Pro Phe Glu Lys Asn Cys Gly 
        675                 680                 685             


Glu Asp Lys Lys Cys Glu Ala Asn Leu Arg Val Ser Phe Ser Pro Ala 
    690                 695                 700                 


Arg Ser Arg Ala Leu Arg Leu Thr Ala Phe Ala Ser Leu Ser Val Glu 
705                 710                 715                 720 


Leu Ser Leu Ser Asn Leu Glu Glu Asp Ala Tyr Trp Val Gln Leu Asp 
                725                 730                 735     


Leu His Phe Pro Pro Gly Leu Ser Phe Arg Lys Val Glu Met Leu Lys 
            740                 745                 750         


Pro His Ser Gln Ile Pro Val Ser Cys Glu Glu Leu Pro Glu Glu Ser 
        755                 760                 765             


Arg Leu Leu Ser Arg Ala Leu Ser Cys Asn Val Ser Ser Pro Ile Phe 
    770                 775                 780                 


Lys Ala Gly His Ser Val Ala Leu Gln Met Met Phe Asn Thr Leu Val 
785                 790                 795                 800 


Asn Ser Ser Trp Gly Asp Ser Val Glu Leu His Ala Asn Val Thr Cys 
                805                 810                 815     


Asn Asn Glu Asp Ser Asp Leu Leu Glu Asp Asn Ser Ala Thr Thr Ile 
            820                 825                 830         


Ile Pro Ile Leu Tyr Pro Ile Asn Ile Leu Ile Gln Asp Gln Glu Asp 
        835                 840                 845             


Ser Thr Leu Tyr Val Ser Phe Thr Pro Lys Gly Pro Lys Ile His Gln 
    850                 855                 860                 


Val Lys His Met Tyr Gln Val Arg Ile Gln Pro Ser Ile His Asp His 
865                 870                 875                 880 


Asn Ile Pro Thr Leu Glu Ala Val Val Gly Val Pro Gln Pro Pro Ser 
                885                 890                 895     


Glu Gly Pro Ile Thr His Gln Trp Ser Val Gln Met Glu Pro Pro Val 
            900                 905                 910         


Pro Cys His Tyr Glu Asp Leu Glu Arg Leu Pro Asp Ala Ala Glu Pro 
        915                 920                 925             


Cys Leu Pro Gly Ala Leu Phe Arg Cys Pro Val Val Phe Arg Gln Glu 
    930                 935                 940                 


Ile Leu Val Gln Val Ile Gly Thr Leu Glu Leu Val Gly Glu Ile Glu 
945                 950                 955                 960 


Ala Ser Ser Met Phe Ser Leu Cys Ser Ser Leu Ser Ile Ser Phe Asn 
                965                 970                 975     


Ser Ser Lys His Phe His Leu Tyr Gly Ser Asn Ala Ser Leu Ala Gln 
            980                 985                 990         


Val Val Met Lys Val Asp Val Val  Tyr Glu Lys Gln Met  Leu Tyr Leu 
        995                 1000                 1005             


Tyr Val  Leu Ser Gly Ile Gly  Gly Leu Leu Leu Leu  Leu Leu Ile 
    1010                 1015                 1020             


Phe Ile  Val Leu Tyr Lys Val  Gly Phe Phe Lys Arg  Asn Leu Lys 
    1025                 1030                 1035             


Glu Lys  Met Glu Ala Gly Arg  Gly Val Pro Asn Gly  Ile Pro Ala 
    1040                 1045                 1050             


Glu Asp  Ser Glu Gln Leu Ala  Ser Gly Gln Glu Ala  Gly Asp Pro 
    1055                 1060                 1065             


Gly Cys  Leu Lys Pro Leu His  Glu Lys Asp Ser Glu  Ser Gly Gly 
    1070                 1075                 1080             


Gly Lys  Asp 
    1085     


<210> 49
<211> 1161
<212> PRT
<213> Mus musculus

<400> 49
Met Ser Phe Arg Ile Ala Gly Pro Arg Leu Leu Leu Leu Gly Leu Gln 
1               5                   10                  15      


Leu Phe Ala Lys Ala Trp Ser Tyr Asn Leu Asp Thr Arg Pro Thr Gln 
            20                  25                  30          


Ser Phe Leu Ala Gln Ala Gly Arg His Phe Gly Tyr Gln Val Leu Gln 
        35                  40                  45              


Ile Glu Asp Gly Val Val Val Gly Ala Pro Gly Glu Gly Asp Asn Thr 
    50                  55                  60                  


Gly Gly Leu Tyr His Cys Arg Thr Ser Ser Glu Phe Cys Gln Pro Val 
65                  70                  75                  80  


Ser Leu His Gly Ser Asn His Thr Ser Lys Tyr Leu Gly Met Thr Leu 
                85                  90                  95      


Ala Thr Asp Ala Ala Lys Gly Ser Leu Leu Ala Cys Asp Pro Gly Leu 
            100                 105                 110         


Ser Arg Thr Cys Asp Gln Asn Thr Tyr Leu Ser Gly Leu Cys Tyr Leu 
        115                 120                 125             


Phe Pro Gln Ser Leu Glu Gly Pro Met Leu Gln Asn Arg Pro Ala Tyr 
    130                 135                 140                 


Gln Glu Cys Met Lys Gly Lys Val Asp Leu Val Phe Leu Phe Asp Gly 
145                 150                 155                 160 


Ser Gln Ser Leu Asp Arg Lys Asp Phe Glu Lys Ile Leu Glu Phe Met 
                165                 170                 175     


Lys Asp Val Met Arg Lys Leu Ser Asn Thr Ser Tyr Gln Phe Ala Ala 
            180                 185                 190         


Val Gln Phe Ser Thr Asp Cys Arg Thr Glu Phe Thr Phe Leu Asp Tyr 
        195                 200                 205             


Val Lys Gln Asn Lys Asn Pro Asp Val Leu Leu Gly Ser Val Gln Pro 
    210                 215                 220                 


Met Phe Leu Leu Thr Asn Thr Phe Arg Ala Ile Asn Tyr Val Val Ala 
225                 230                 235                 240 


His Val Phe Lys Glu Glu Ser Gly Ala Arg Pro Asp Ala Thr Lys Val 
                245                 250                 255     


Leu Val Ile Ile Thr Asp Gly Glu Ala Ser Asp Lys Gly Asn Ile Ser 
            260                 265                 270         


Ala Ala His Asp Ile Thr Arg Tyr Ile Ile Gly Ile Gly Lys His Phe 
        275                 280                 285             


Val Ser Val Gln Lys Gln Lys Thr Leu His Ile Phe Ala Ser Glu Pro 
    290                 295                 300                 


Val Glu Glu Phe Val Lys Ile Leu Asp Thr Phe Glu Lys Leu Lys Asp 
305                 310                 315                 320 


Leu Phe Thr Asp Leu Gln Arg Arg Ile Tyr Ala Ile Glu Gly Thr Asn 
                325                 330                 335     


Arg Gln Asp Leu Thr Ser Phe Asn Met Glu Leu Ser Ser Ser Gly Ile 
            340                 345                 350         


Ser Ala Asp Leu Ser Lys Gly His Ala Val Val Gly Ala Val Gly Ala 
        355                 360                 365             


Lys Asp Trp Ala Gly Gly Phe Leu Asp Leu Arg Glu Asp Leu Gln Gly 
    370                 375                 380                 


Ala Thr Phe Val Gly Gln Glu Pro Leu Thr Ser Asp Val Arg Gly Gly 
385                 390                 395                 400 


Tyr Leu Gly Tyr Thr Val Ala Trp Met Thr Ser Arg Ser Ser Arg Pro 
                405                 410                 415     


Leu Leu Ala Ala Gly Ala Pro Arg Tyr Gln His Val Gly Gln Val Leu 
            420                 425                 430         


Leu Phe Gln Ala Pro Glu Ala Gly Gly Arg Trp Asn Gln Thr Gln Lys 
        435                 440                 445             


Ile Glu Gly Thr Gln Ile Gly Ser Tyr Phe Gly Gly Glu Leu Cys Ser 
    450                 455                 460                 


Val Asp Leu Asp Gln Asp Gly Glu Ala Glu Leu Leu Leu Ile Gly Ala 
465                 470                 475                 480 


Pro Leu Phe Phe Gly Glu Gln Arg Gly Gly Arg Val Phe Thr Tyr Gln 
                485                 490                 495     


Arg Arg Gln Ser Leu Phe Glu Met Val Ser Glu Leu Gln Gly Asp Pro 
            500                 505                 510         


Gly Tyr Pro Leu Gly Arg Phe Gly Ala Ala Ile Thr Ala Leu Thr Asp 
        515                 520                 525             


Ile Asn Gly Asp Arg Leu Thr Asp Val Ala Val Gly Ala Pro Leu Glu 
    530                 535                 540                 


Glu Gln Gly Ala Val Tyr Ile Phe Asn Gly Lys Pro Gly Gly Leu Ser 
545                 550                 555                 560 


Pro Gln Pro Ser Gln Arg Ile Gln Gly Ala Gln Val Phe Pro Gly Ile 
                565                 570                 575     


Arg Trp Phe Gly Arg Ser Ile His Gly Val Lys Asp Leu Gly Gly Asp 
            580                 585                 590         


Arg Leu Ala Asp Val Val Val Gly Ala Glu Gly Arg Val Val Val Leu 
        595                 600                 605             


Ser Ser Arg Pro Val Val Asp Val Val Thr Glu Leu Ser Phe Ser Pro 
    610                 615                 620                 


Glu Glu Ile Pro Val His Glu Val Glu Cys Ser Tyr Ser Ala Arg Glu 
625                 630                 635                 640 


Glu Gln Lys His Gly Val Lys Leu Lys Ala Cys Phe Arg Ile Lys Pro 
                645                 650                 655     


Leu Thr Pro Gln Phe Gln Gly Arg Leu Leu Ala Asn Leu Ser Tyr Thr 
            660                 665                 670         


Leu Gln Leu Asp Gly His Arg Met Arg Ser Arg Gly Leu Phe Pro Asp 
        675                 680                 685             


Gly Ser His Glu Leu Ser Gly Asn Thr Ser Ile Thr Pro Asp Lys Ser 
    690                 695                 700                 


Cys Leu Asp Phe His Phe His Phe Pro Ile Cys Ile Gln Asp Leu Ile 
705                 710                 715                 720 


Ser Pro Ile Asn Val Ser Leu Asn Phe Ser Leu Leu Glu Glu Glu Gly 
                725                 730                 735     


Thr Pro Arg Asp Gln Lys Gly Arg Ala Met Gln Pro Ile Leu Arg Pro 
            740                 745                 750         


Ser Ile His Thr Val Thr Lys Glu Ile Pro Phe Glu Lys Asn Cys Gly 
        755                 760                 765             


Glu Asp Lys Lys Cys Glu Ala Asn Leu Thr Leu Ser Ser Pro Ala Arg 
    770                 775                 780                 


Ser Gly Pro Leu Arg Leu Met Ser Ser Ala Ser Leu Ala Val Glu Trp 
785                 790                 795                 800 


Thr Leu Ser Asn Ser Gly Glu Asp Ala Tyr Trp Val Arg Leu Asp Leu 
                805                 810                 815     


Asp Phe Pro Arg Gly Leu Ser Phe Arg Lys Val Glu Met Leu Gln Pro 
            820                 825                 830         


His Ser Arg Met Pro Val Ser Cys Glu Glu Leu Thr Glu Gly Ser Ser 
        835                 840                 845             


Leu Leu Thr Lys Thr Leu Lys Cys Asn Val Ser Ser Pro Ile Phe Lys 
    850                 855                 860                 


Ala Gly Gln Glu Val Ser Leu Gln Val Met Phe Asn Thr Leu Leu Asn 
865                 870                 875                 880 


Ser Ser Trp Glu Asp Phe Val Glu Leu Asn Gly Thr Val His Cys Glu 
                885                 890                 895     


Asn Glu Asn Ser Ser Leu Gln Glu Asp Asn Ser Ala Ala Thr His Ile 
            900                 905                 910         


Pro Val Leu Tyr Pro Val Asn Ile Leu Thr Lys Glu Gln Glu Asn Ser 
        915                 920                 925             


Thr Leu Tyr Ile Ser Phe Thr Pro Lys Gly Pro Lys Thr Gln Gln Val 
    930                 935                 940                 


Gln His Val Tyr Gln Val Arg Ile Gln Pro Ser Ala Tyr Asp His Asn 
945                 950                 955                 960 


Met Pro Thr Leu Glu Ala Leu Val Gly Val Pro Trp Pro His Ser Glu 
                965                 970                 975     


Asp Pro Ile Thr Tyr Thr Trp Ser Val Gln Thr Asp Pro Leu Val Thr 
            980                 985                 990         


Cys His Ser Glu Asp Leu Lys Arg  Pro Ser Ser Glu Ala  Glu Gln Pro 
        995                 1000                 1005             


Cys Leu  Pro Gly Val Gln Phe  Arg Cys Pro Ile Val  Phe Arg Arg 
    1010                 1015                 1020             


Glu Ile  Leu Ile Gln Val Thr  Gly Thr Val Glu Leu  Ser Lys Glu 
    1025                 1030                 1035             


Ile Lys  Ala Ser Ser Thr Leu  Ser Leu Cys Ser Ser  Leu Ser Val 
    1040                 1045                 1050             


Ser Phe  Asn Ser Ser Lys His  Phe His Leu Tyr Gly  Ser Lys Ala 
    1055                 1060                 1065             


Ser Glu  Ala Gln Val Leu Val  Lys Val Asp Leu Ile  His Glu Lys 
    1070                 1075                 1080             


Glu Met  Leu His Val Tyr Val  Leu Ser Gly Ile Gly  Gly Leu Val 
    1085                 1090                 1095             


Leu Leu  Phe Leu Ile Phe Leu  Ala Leu Tyr Lys Val  Gly Phe Phe 
    1100                 1105                 1110             


Lys Arg  Asn Leu Lys Glu Lys  Met Glu Ala Asp Gly  Gly Val Pro 
    1115                 1120                 1125             


Asn Gly  Ser Pro Pro Glu Asp  Thr Asp Pro Leu Ala  Val Pro Gly 
    1130                 1135                 1140             


Glu Glu  Thr Lys Asp Met Gly  Cys Leu Glu Pro Leu  Arg Glu Ser 
    1145                 1150                 1155             


Asp Lys  Asp 
    1160     


<210> 50
<211> 370
<212> PRT
<213> Homo sapiens

<400> 50
Met Gly Leu Trp Ala Leu Leu Pro Gly Trp Val Ser Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Ala Leu Pro Ala Ala Leu Ala Ala Asn Ser Ser Gly 
            20                  25                  30          


Arg Trp Trp Gly Ile Val Asn Val Ala Ser Ser Thr Asn Leu Leu Thr 
        35                  40                  45              


Asp Ser Lys Ser Leu Gln Leu Val Leu Glu Pro Ser Leu Gln Leu Leu 
    50                  55                  60                  


Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn Pro Gly Ile Leu His 
65                  70                  75                  80  


Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg Glu Cys Lys Trp Gln 
                85                  90                  95      


Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala Pro Gly Pro His Leu 
            100                 105                 110         


Phe Gly Lys Ile Val Asn Arg Gly Cys Arg Glu Thr Ala Phe Ile Phe 
        115                 120                 125             


Ala Ile Thr Ser Ala Gly Val Thr His Ser Val Ala Arg Ser Cys Ser 
    130                 135                 140                 


Glu Gly Ser Ile Glu Ser Cys Thr Cys Asp Tyr Arg Arg Arg Gly Pro 
145                 150                 155                 160 


Gly Gly Pro Asp Trp His Trp Gly Gly Cys Ser Asp Asn Ile Asp Phe 
                165                 170                 175     


Gly Arg Leu Phe Gly Arg Glu Phe Val Asp Ser Gly Glu Lys Gly Arg 
            180                 185                 190         


Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Thr 
        195                 200                 205             


Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys Cys His Gly Met Ser 
    210                 215                 220                 


Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg Leu Pro Thr Leu Arg 
225                 230                 235                 240 


Ala Val Gly Asp Val Leu Arg Asp Arg Phe Asp Gly Ala Ser Arg Val 
                245                 250                 255     


Leu Tyr Gly Asn Arg Gly Ser Asn Arg Ala Ser Arg Ala Glu Leu Leu 
            260                 265                 270         


Arg Leu Glu Pro Glu Asp Pro Ala His Lys Pro Pro Ser Pro His Asp 
        275                 280                 285             


Leu Val Tyr Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly Arg 
    290                 295                 300                 


Leu Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser Pro 
305                 310                 315                 320 


Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg Thr 
                325                 330                 335     


Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe His Trp Cys 
            340                 345                 350         


Cys His Val Ser Cys Arg Asn Cys Thr His Thr Arg Val Leu His Glu 
        355                 360                 365             


Cys Leu 
    370 


<210> 51
<211> 370
<212> PRT
<213> Mus musculus

<400> 51
Met Gly Leu Trp Ala Leu Leu Pro Ser Trp Val Ser Thr Thr Leu Leu 
1               5                   10                  15      


Leu Ala Leu Thr Ala Leu Pro Ala Ala Leu Ala Ala Asn Ser Ser Gly 
            20                  25                  30          


Arg Trp Trp Gly Ile Val Asn Ile Ala Ser Ser Thr Asn Leu Leu Thr 
        35                  40                  45              


Asp Ser Lys Ser Leu Gln Leu Val Leu Glu Pro Ser Leu Gln Leu Leu 
    50                  55                  60                  


Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn Pro Gly Ile Leu His 
65                  70                  75                  80  


Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg Glu Cys Lys Trp Gln 
                85                  90                  95      


Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala Pro Gly Pro His Leu 
            100                 105                 110         


Phe Gly Lys Ile Val Asn Arg Gly Cys Arg Glu Thr Ala Phe Ile Phe 
        115                 120                 125             


Ala Ile Thr Ser Ala Gly Val Thr His Ser Val Ala Arg Ser Cys Ser 
    130                 135                 140                 


Glu Gly Ser Ile Glu Ser Cys Thr Cys Asp Tyr Arg Arg Arg Gly Pro 
145                 150                 155                 160 


Gly Gly Pro Asp Trp His Trp Gly Gly Cys Ser Asp Asn Ile Asp Phe 
                165                 170                 175     


Gly Arg Leu Phe Gly Arg Glu Phe Val Asp Ser Gly Glu Lys Gly Arg 
            180                 185                 190         


Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Thr 
        195                 200                 205             


Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys Cys His Gly Met Ser 
    210                 215                 220                 


Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg Leu Pro Thr Leu Arg 
225                 230                 235                 240 


Ala Val Gly Asp Val Leu Arg Asp Arg Phe Asp Gly Ala Ser Arg Val 
                245                 250                 255     


Leu Tyr Gly Asn Arg Gly Ser Asn Arg Ala Ser Arg Ala Glu Leu Leu 
            260                 265                 270         


Arg Leu Glu Pro Glu Asp Pro Ala His Lys Pro Pro Ser Pro His Asp 
        275                 280                 285             


Leu Val Tyr Phe Glu Lys Ser Pro Asn Phe Cys Thr Tyr Ser Gly Arg 
    290                 295                 300                 


Leu Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys Asn Ser Ser Ser Pro 
305                 310                 315                 320 


Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly His Arg Thr 
                325                 330                 335     


Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys Thr Phe His Trp Cys 
            340                 345                 350         


Cys His Val Ser Cys Arg Asn Cys Thr His Thr Arg Val Leu His Glu 
        355                 360                 365             


Cys Leu 
    370 


<210> 52
<211> 23
<212> PRT
<213> Influenza A virus

<400> 52
Ile Ile Thr Ile Gly Ser Val Cys Met Thr Ile Gly Met Ala Asn Leu 
1               5                   10                  15      


Ile Leu Gln Ile Gly Asn Ile 
            20              


<210> 53
<211> 23
<212> PRT
<213> Influenza A virus

<400> 53
Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val Val Ser 
1               5                   10                  15      


Leu Gly Ala Ile Ser Phe Trp 
            20              


<210> 54
<211> 52
<212> PRT
<213> Dengue virus

<400> 54
Ala Tyr Gly Val Leu Phe Ser Gly Val Ser Trp Thr Met Lys Ile Gly 
1               5                   10                  15      


Ile Gly Ile Leu Leu Thr Trp Leu Gly Leu Asn Ser Arg Ser Thr Ser 
            20                  25                  30          


Leu Ser Met Thr Cys Ile Ala Val Gly Met Val Thr Leu Tyr Leu Gly 
        35                  40                  45              


Val Met Val Gln 
    50          


<210> 55
<211> 21
<212> PRT
<213> Human immunodeficiency virus 1

<400> 55
Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala 
1               5                   10                  15      


Val Leu Ser Ile Val 
            20      


<210> 56
<211> 274
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu 
        35                  40                  45              


Thr Glu Leu Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Val Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Ser Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Ser Phe Pro Ile Arg Gly Asp Pro Ser Tyr Tyr 
        115                 120                 125             


Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
                165                 170                 175     


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
            180                 185                 190         


Ser Gln Gly Ile Thr Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly 
        195                 200                 205             


Lys Ala Pro Lys Ser Leu Ile Tyr Ala Val Ser Ser Leu Gln Ser Gly 
    210                 215                 220                 


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
225                 230                 235                 240 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
                245                 250                 255     


Gln Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys 
        


<210> 57
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 57
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Phe Asp Asp Ser Ser Phe Trp Ala Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                245                 250                 255     


Ala Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            260                 265             


<210> 58
<211> 737
<212> PRT
<213> Homo sapiens

<400> 58
Lys Gly Thr Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu 
1               5                   10                  15      


Thr Asp Tyr Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg 
            20                  25                  30          


Trp Ile Ser Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu 
        35                  40                  45              


Val Phe Asn Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser 
    50                  55                  60                  


Thr Phe Asp Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro 
65                  70                  75                  80  


Asp Gly Gln Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg 
                85                  90                  95      


His Ser Tyr Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln 
            100                 105                 110         


Leu Ile Thr Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp 
        115                 120                 125             


Ser Pro Val Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr 
    130                 135                 140                 


Val Lys Ile Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly 
145                 150                 155                 160 


Lys Glu Asp Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu 
                165                 170                 175     


Glu Val Phe Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr 
            180                 185                 190         


Phe Leu Ala Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu 
        195                 200                 205             


Tyr Ser Phe Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg 
    210                 215                 220                 


Val Pro Tyr Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe 
225                 230                 235                 240 


Val Val Asn Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile 
                245                 250                 255     


Gln Ile Thr Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys 
            260                 265                 270         


Asp Val Thr Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg 
        275                 280                 285             


Arg Ile Gln Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser 
    290                 295                 300                 


Ser Gly Arg Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser 
305                 310                 315                 320 


Thr Thr Gly Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr 
                325                 330                 335     


Leu Asp Gly Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr 
            340                 345                 350         


Arg His Ile Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile 
        355                 360                 365             


Thr Lys Gly Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp 
    370                 375                 380                 


Tyr Leu Tyr Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg 
385                 390                 395                 400 


Asn Leu Tyr Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu 
                405                 410                 415     


Ser Cys Glu Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe 
            420                 425                 430         


Ser Lys Glu Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu 
        435                 440                 445             


Pro Leu Tyr Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val 
    450                 455                 460                 


Leu Glu Asp Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met 
465                 470                 475                 480 


Pro Ser Lys Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp 
                485                 490                 495     


Tyr Gln Met Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro 
            500                 505                 510         


Leu Leu Leu Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr 
        515                 520                 525             


Val Phe Arg Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile 
    530                 535                 540                 


Ile Val Ala Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys 
545                 550                 555                 560 


Ile Met His Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp 
                565                 570                 575     


Gln Ile Glu Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn 
            580                 585                 590         


Lys Arg Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser 
        595                 600                 605             


Met Val Leu Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val 
    610                 615                 620                 


Ala Pro Val Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg 
625                 630                 635                 640 


Tyr Met Gly Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn 
                645                 650                 655     


Ser Thr Val Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu 
            660                 665                 670         


Leu Ile His Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala 
        675                 680                 685             


Gln Ile Ser Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met 
    690                 695                 700                 


Trp Tyr Thr Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln 
705                 710                 715                 720 


His Ile Tyr Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu 
                725                 730                 735     


Pro 
    


<210> 59
<211> 740
<212> PRT
<213> Homo sapiens

<400> 59
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Ala Glu Met Gly Ala Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser 
            740 


<210> 60
<211> 335
<212> PRT
<213> Mus sp.

<400> 60
Met Ile Ala Met Leu Thr Val Leu Leu Tyr Leu Gly Leu Ile Leu Glu 
1               5                   10                  15      


Pro Arg Thr Ala Val Gln Ala Gly His Leu Pro Lys Pro Ile Ile Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ala Ala Tyr Thr Ser Val Ile Thr Trp 
        35                  40                  45              


Cys Gln Gly Ser Trp Glu Ala Gln Tyr Tyr His Leu Tyr Lys Glu Lys 
    50                  55                  60                  


Ser Val Asn Pro Trp Asp Thr Gln Val Pro Leu Glu Thr Arg Asn Lys 
65                  70                  75                  80  


Ala Lys Phe Asn Ile Pro Ser Met Thr Thr Ser Tyr Ala Gly Ile Tyr 
                85                  90                  95      


Lys Cys Tyr Tyr Glu Ser Ala Ala Gly Phe Ser Glu His Ser Asp Ala 
            100                 105                 110         


Met Glu Leu Val Met Thr Gly Ala Tyr Glu Asn Pro Ser Leu Ser Val 
        115                 120                 125             


Tyr Pro Ser Ser Asn Val Thr Ser Gly Val Ser Ile Ser Phe Ser Cys 
    130                 135                 140                 


Ser Ser Ser Ile Val Phe Gly Arg Phe Ile Leu Ile Gln Glu Gly Lys 
145                 150                 155                 160 


His Gly Leu Ser Trp Thr Leu Asp Ser Gln His Gln Ala Asn Gln Pro 
                165                 170                 175     


Ser Tyr Ala Thr Phe Val Leu Asp Ala Val Thr Pro Asn His Asn Gly 
            180                 185                 190         


Thr Phe Arg Cys Tyr Gly Tyr Phe Arg Asn Glu Pro Gln Val Trp Ser 
        195                 200                 205             


Lys Pro Ser Asn Ser Leu Asp Leu Met Ile Ser Glu Thr Lys Asp Gln 
    210                 215                 220                 


Ser Ser Thr Pro Thr Glu Asp Gly Leu Glu Thr Tyr Gln Lys Ile Leu 
225                 230                 235                 240 


Ile Gly Val Leu Val Ser Phe Leu Leu Leu Phe Phe Leu Leu Leu Phe 
                245                 250                 255     


Leu Ile Leu Ile Gly Tyr Gln Tyr Gly His Lys Lys Lys Ala Asn Ala 
            260                 265                 270         


Ser Val Lys Asn Thr Gln Ser Glu Asn Asn Ala Glu Leu Asn Ser Trp 
        275                 280                 285             


Asn Pro Gln Asn Glu Asp Pro Gln Gly Ile Val Tyr Ala Gln Val Lys 
    290                 295                 300                 


Pro Ser Arg Leu Gln Lys Asp Thr Ala Cys Lys Glu Thr Gln Asp Val 
305                 310                 315                 320 


Thr Tyr Ala Gln Leu Cys Ile Arg Thr Gln Glu Gln Asn Asn Ser 
                325                 330                 335 


<210> 61
<211> 247
<212> PRT
<213> Homo sapiens

<400> 61
Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu 
                245         


<210> 62
<211> 133
<212> PRT
<213> Homo sapiens

<400> 62
Met Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210> 63
<211> 205
<212> PRT
<213> Homo sapiens

<400> 63
Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210> 64
<211> 267
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Asp Ile Lys Leu Gln Gln Ser Gly 
            20                  25                  30          


Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
65                  70                  75                  80  


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr 
                85                  90                  95      


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
        115                 120                 125             


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val 
    130                 135                 140                 


Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val 
145                 150                 155                 160 


Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
                165                 170                 175     


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
            180                 185                 190         


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
        195                 200                 205             


Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
225                 230                 235                 240 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            260                 265         


<210> 65
<211> 53
<212> PRT
<213> Mus sp.

<400> 65
Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Ala Leu Leu Leu Pro Thr Gln Ile Tyr Cys Asn Gln Thr Ser Val Ala 
            20                  25                  30          


Pro Phe Pro Gly Asn Gln Asn Ile Ser Ala Ser Pro Asn Pro Ser Asn 
        35                  40                  45              


Ala Thr Thr Arg Gly 
    50              


<210> 66
<211> 243
<212> PRT
<213> Homo sapiens

<400> 66
Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Phe Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210> 67
<211> 190
<212> PRT
<213> Mus sp.

<400> 67
Met Gly Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          


Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  


Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  


Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      


Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         


Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 


Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Lys Pro Glu Gly Arg Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu 
            180                 185                 190 


<210> 68
<211> 349
<212> PRT
<213> Homo sapiens

<400> 68
Met Glu Ala His Asn Ala Ser Ala Pro Phe Asn Phe Thr Leu Pro Pro 
1               5                   10                  15      


Asn Phe Gly Lys Arg Pro Thr Asp Leu Ala Leu Ser Val Ile Leu Val 
            20                  25                  30          


Phe Met Leu Phe Phe Ile Met Leu Ser Leu Gly Cys Thr Met Glu Phe 
        35                  40                  45              


Ser Lys Ile Lys Ala His Leu Trp Lys Pro Lys Gly Leu Ala Ile Ala 
    50                  55                  60                  


Leu Val Ala Gln Tyr Gly Ile Met Pro Leu Thr Ala Phe Val Leu Gly 
65                  70                  75                  80  


Lys Val Phe Arg Leu Lys Asn Ile Glu Ala Leu Ala Ile Leu Val Cys 
                85                  90                  95      


Gly Cys Ser Pro Gly Gly Asn Leu Ser Asn Val Phe Ser Leu Ala Met 
            100                 105                 110         


Lys Gly Asp Met Asn Leu Ser Ile Val Met Thr Thr Cys Ser Thr Phe 
        115                 120                 125             


Cys Ala Leu Gly Met Met Pro Leu Leu Leu Tyr Ile Tyr Ser Arg Gly 
    130                 135                 140                 


Ile Tyr Asp Gly Asp Leu Lys Asp Lys Val Pro Tyr Lys Gly Ile Val 
145                 150                 155                 160 


Ile Ser Leu Val Leu Val Leu Ile Pro Cys Thr Ile Gly Ile Val Leu 
                165                 170                 175     


Lys Ser Lys Arg Pro Gln Tyr Met Arg Tyr Val Ile Lys Gly Gly Met 
            180                 185                 190         


Ile Ile Ile Leu Leu Cys Ser Val Ala Val Thr Val Leu Ser Ala Ile 
        195                 200                 205             


Asn Val Gly Lys Ser Ile Met Phe Ala Met Thr Pro Leu Leu Ile Ala 
    210                 215                 220                 


Thr Ser Ser Leu Met Pro Phe Ile Gly Phe Leu Leu Gly Tyr Val Leu 
225                 230                 235                 240 


Ser Ala Leu Phe Cys Leu Asn Gly Arg Cys Arg Arg Thr Val Ser Met 
                245                 250                 255     


Glu Thr Gly Cys Gln Asn Val Gln Leu Cys Ser Thr Ile Leu Asn Val 
            260                 265                 270         


Ala Phe Pro Pro Glu Val Ile Gly Pro Leu Phe Phe Phe Pro Leu Leu 
        275                 280                 285             


Tyr Met Ile Phe Gln Leu Gly Glu Gly Leu Leu Leu Ile Ala Ile Phe 
    290                 295                 300                 


Trp Cys Tyr Glu Lys Phe Lys Thr Pro Lys Asp Lys Thr Lys Met Ile 
305                 310                 315                 320 


Tyr Thr Ala Ala Thr Thr Glu Glu Thr Ile Pro Gly Ala Leu Gly Asn 
                325                 330                 335     


Gly Thr Tyr Lys Gly Glu Asp Cys Ser Pro Cys Thr Ala 
            340                 345                 


<210> 69
<211> 191
<212> PRT
<213> Mus sp.

<400> 69
Met Thr Cys Leu Gly Leu Arg Arg Tyr Lys Ala Gln Leu Gln Leu Pro 
1               5                   10                  15      


Ser Arg Thr Trp Pro Phe Val Ala Leu Leu Thr Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser Glu Ala Ile Gln Val Thr Gln Pro Ser Val Val Leu Ala 
        35                  40                  45              


Ser Ser His Gly Val Ala Ser Phe Pro Cys Glu Tyr Ser Pro Ser His 
    50                  55                  60                  


Asn Thr Asp Glu Val Arg Val Thr Val Leu Arg Gln Thr Asn Asp Gln 
65                  70                  75                  80  


Met Thr Glu Val Cys Ala Thr Thr Phe Thr Glu Lys Asn Thr Val Gly 
                85                  90                  95      


Phe Leu Asp Tyr Pro Phe Cys Ser Gly Thr Phe Asn Glu Ser Arg Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Leu 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val Gly Met Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Val Ala Val Ser Leu Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Val Thr Ala Val Ser Leu Ser Lys Arg Ile Gln 
            180                 185                 190     


<210> 70
<211> 246
<212> PRT
<213> Homo sapiens

<400> 70
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser 
                245     


<210> 71
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ser Arg Gly Met Leu Asp Ser Asp Leu His Leu Ser 
            740                 745                 750         


Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser 
        755                 760                 765             


Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser 
    770                 775                 780                 


Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser 
785                 790                 795                 800 


Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe 
                805                 810                 815     


Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr 
            820                 825                 830         


Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        835                 840                 845             


<210> 72
<211> 740
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser 
            740 


<210> 73
<211> 978
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 73
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Ala Glu Met Gly Ala Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ser Arg Ile Gln Ala Asp Gly Trp Met Cys His Ala 
            740                 745                 750         


Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr 
        755                 760                 765             


Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys 
    770                 775                 780                 


Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe 
785                 790                 795                 800 


Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val 
                805                 810                 815     


Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly 
            820                 825                 830         


Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile 
        835                 840                 845             


Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val 
    850                 855                 860                 


Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His 
865                 870                 875                 880 


Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala 
                885                 890                 895     


Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly 
            900                 905                 910         


Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp 
        915                 920                 925             


Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly 
    930                 935                 940                 


Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys 
945                 950                 955                 960 


His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu 
                965                 970                 975     


Gly Lys 
        


<210> 74
<211> 740
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 74
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser 
            740 


<210> 75
<211> 740
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 75
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser 
            740 


<210> 76
<211> 801
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 76
Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Gly Ser Lys Gly Thr Asp Asp 
        35                  40                  45              


Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr Leu Lys 
    50                  55                  60                  


Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser Asp His 
65                  70                  75                  80  


Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn Ala Glu 
                85                  90                  95      


Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp Glu Phe 
            100                 105                 110         


Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln Phe Ile 
        115                 120                 125             


Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr Thr Ala 
    130                 135                 140                 


Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr Glu Glu 
145                 150                 155                 160 


Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val Gly His 
                165                 170                 175     


Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile Glu Pro 
            180                 185                 190         


Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp Ile Ile 
        195                 200                 205             


Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe Ser Ala 
    210                 215                 220                 


Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala Tyr Ala 
225                 230                 235                 240 


Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe Tyr Ser 
                245                 250                 255     


Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr Pro Lys 
            260                 265                 270         


Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn Thr Asp 
        275                 280                 285             


Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr Ala Pro 
    290                 295                 300                 


Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr Trp Ala 
305                 310                 315                 320 


Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln Asn Tyr 
                325                 330                 335     


Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg Trp Asn 
            340                 345                 350         


Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly Trp Val 
        355                 360                 365             


Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly Asn Ser 
    370                 375                 380                 


Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile Cys Tyr 
385                 390                 395                 400 


Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly Thr Trp 
                405                 410                 415     


Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr Tyr Ile 
            420                 425                 430         


Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr Lys Ile 
        435                 440                 445             


Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu Leu Asn 
    450                 455                 460                 


Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu Ala Lys 
465                 470                 475                 480 


Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr Thr Leu 
                485                 490                 495     


His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp Asn Ser 
            500                 505                 510         


Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys Lys Leu 
        515                 520                 525             


Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met Ile Leu 
    530                 535                 540                 


Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu Asp Val 
545                 550                 555                 560 


Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg Leu Asn 
                565                 570                 575     


Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala Ser Phe 
            580                 585                 590         


Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His Ala Ile 
        595                 600                 605             


Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu Ala Ala 
    610                 615                 620                 


Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile Ala Ile 
625                 630                 635                 640 


Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu Gly Ser 
                645                 650                 655     


Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Arg 
            660                 665                 670         


Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly Leu Pro 
        675                 680                 685             


Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val Met Ser 
    690                 695                 700                 


Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His Gly Thr 
705                 710                 715                 720 


Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser Lys Ala 
                725                 730                 735     


Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr Asp Glu 
            740                 745                 750         


Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr Thr His 
        755                 760                 765             


Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro Ala Ala Ala Arg 
    770                 775                 780                 


Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
785                 790                 795                 800 


Glu 
    


<210> 77
<211> 836
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 77
Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Thr Gly Ile Val Ser Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile His Thr Gly Asn Gln His Gln Ser Glu Pro 
        35                  40                  45              


Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys 
    50                  55                  60                  


Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Asn Gly Gly Ser Lys Gly 
65                  70                  75                  80  


Thr Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp 
                85                  90                  95      


Tyr Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile 
            100                 105                 110         


Ser Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe 
        115                 120                 125             


Asn Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe 
    130                 135                 140                 


Asp Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly 
145                 150                 155                 160 


Gln Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser 
                165                 170                 175     


Tyr Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile 
            180                 185                 190         


Thr Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro 
        195                 200                 205             


Val Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys 
    210                 215                 220                 


Ile Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu 
225                 230                 235                 240 


Asp Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val 
                245                 250                 255     


Phe Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu 
            260                 265                 270         


Ala Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser 
        275                 280                 285             


Phe Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro 
    290                 295                 300                 


Tyr Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val 
305                 310                 315                 320 


Asn Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile 
                325                 330                 335     


Thr Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val 
            340                 345                 350         


Thr Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile 
        355                 360                 365             


Gln Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly 
    370                 375                 380                 


Arg Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr 
385                 390                 395                 400 


Gly Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp 
                405                 410                 415     


Gly Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His 
            420                 425                 430         


Ile Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys 
        435                 440                 445             


Gly Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu 
    450                 455                 460                 


Tyr Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu 
465                 470                 475                 480 


Tyr Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys 
                485                 490                 495     


Glu Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys 
            500                 505                 510         


Glu Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu 
        515                 520                 525             


Tyr Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu 
    530                 535                 540                 


Asp Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser 
545                 550                 555                 560 


Lys Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln 
                565                 570                 575     


Met Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu 
            580                 585                 590         


Leu Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe 
        595                 600                 605             


Arg Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val 
    610                 615                 620                 


Ala Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met 
625                 630                 635                 640 


His Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile 
                645                 650                 655     


Glu Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg 
            660                 665                 670         


Ile Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val 
        675                 680                 685             


Leu Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro 
    690                 695                 700                 


Val Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met 
705                 710                 715                 720 


Gly Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr 
                725                 730                 735     


Val Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile 
            740                 745                 750         


His Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile 
        755                 760                 765             


Ser Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr 
    770                 775                 780                 


Thr Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile 
785                 790                 795                 800 


Tyr Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro Ala 
                805                 810                 815     


Ala Ala Arg Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
            820                 825                 830         


Glu Trp His Glu 
        835     


<210> 78
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu 
        35                  40                  45              


Thr Glu Leu Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Val Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Ser Asp 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Ser Phe Pro Ile Arg Gly Asp Pro Ser Tyr Tyr 
        115                 120                 125             


Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
                165                 170                 175     


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
            180                 185                 190         


Ser Gln Gly Ile Thr Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly 
        195                 200                 205             


Lys Ala Pro Lys Ser Leu Ile Tyr Ala Val Ser Ser Leu Gln Ser Gly 
    210                 215                 220                 


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
225                 230                 235                 240 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
                245                 250                 255     


Gln Tyr Asn Ser Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
            260                 265                 270         


Ile Lys Asp Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys 
        275                 280                 285             


Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr 
    290                 295                 300                 


His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser 
305                 310                 315                 320 


Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro 
                325                 330                 335     


Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val 
            340                 345                 350         


Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
        355                 360                 365             


Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro 
    370                 375                 380                 


Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly 
385                 390                 395                 400 


Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser 
                405                 410                 415     


Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser 
            420                 425                 430         


Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser 
        435                 440                 445             


Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser 
    450                 455                 460                 


Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe 
465                 470                 475                 480 


Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr 
                485                 490                 495     


Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510         


<210> 79
<211> 376
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Phe Asp Asp Ser Ser Phe Trp Ala Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            180                 185                 190         


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                245                 250                 255     


Ala Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Arg Gly Met 
            260                 265                 270         


Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His 
        275                 280                 285             


Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu 
    290                 295                 300                 


Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu 
305                 310                 315                 320 


Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile 
                325                 330                 335     


Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His 
            340                 345                 350         


Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp 
        355                 360                 365             


Ile Glu Met Asn Arg Leu Gly Lys 
    370                 375     


<210> 80
<211> 952
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Ala Glu Met Gly Ala Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ser Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
            740                 745                 750         


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
        755                 760                 765             


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
    770                 775                 780                 


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
785                 790                 795                 800 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
                805                 810                 815     


Val Leu Arg Val Gly Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala 
            820                 825                 830         


Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr 
        835                 840                 845             


Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys 
    850                 855                 860                 


Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe 
865                 870                 875                 880 


Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val 
                885                 890                 895     


Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly 
            900                 905                 910         


Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile 
        915                 920                 925             


Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val 
    930                 935                 940                 


Lys Gly Leu Cys Asp Ser Asn Leu 
945                 950         


<210> 81
<211> 948
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Ala Glu Met Gly Ala Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ser Arg Ile Gln Ala Asp Gly Trp Met Cys His Ala 
            740                 745                 750         


Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr 
        755                 760                 765             


Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys 
    770                 775                 780                 


Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe 
785                 790                 795                 800 


Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val 
                805                 810                 815     


Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly 
            820                 825                 830         


Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Gly Met Leu Asp Ser Asp 
        835                 840                 845             


Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln 
    850                 855                 860                 


Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp 
865                 870                 875                 880 


Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser 
                885                 890                 895     


Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile 
            900                 905                 910         


Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys 
        915                 920                 925             


Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn 
    930                 935                 940                 


Arg Leu Gly Lys 
945             


<210> 82
<211> 932
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His Ala Glu Met Gly Ala Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ser Arg Ile Gln Ala Asp Gly Trp Met Cys His Ala 
            740                 745                 750         


Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr 
        755                 760                 765             


Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys 
    770                 775                 780                 


Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe 
785                 790                 795                 800 


Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val 
                805                 810                 815     


Ile Val Gln Val Thr Pro His His Val Leu Gly Met Leu Asp Ser Asp 
            820                 825                 830         


Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln 
        835                 840                 845             


Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp 
    850                 855                 860                 


Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser 
865                 870                 875                 880 


Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile 
                885                 890                 895     


Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys 
            900                 905                 910         


Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn 
        915                 920                 925             


Arg Leu Gly Lys 
    930         


<210> 83
<211> 529
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Met Thr Phe Val Phe Thr Ala Val Leu Cys Leu Gly Leu Asn Leu Gly 
1               5                   10                  15      


Gln Glu Thr Ser Met Ser Glu Gly Asn Pro His Lys Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Pro Gly Leu Val Val Ala Lys Gly Lys Gln Val Thr Ile Ser 
        35                  40                  45              


Cys Glu Val Thr Thr Gly Ala Arg Glu Tyr Arg Leu Tyr Lys Glu Gly 
    50                  55                  60                  


Gly Pro His Pro Trp Arg Thr Arg Asn Thr Pro Lys Thr Thr Asn Lys 
65                  70                  75                  80  


Ala Gln Phe Leu Ile Pro Ser Ile Glu Gln Arg Ser Gly Gly Ile Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Lys Thr Pro Thr Gly Trp Ser Glu His Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Ala Val Thr Gly Leu Tyr Ser Lys Pro Ser Leu Ser Thr 
        115                 120                 125             


Gln Pro Ser Asn Val Val Asn Ser Gly Glu Thr Val Thr Leu Gln Cys 
    130                 135                 140                 


Val Ser Thr Leu Gly Phe Asn Arg Phe Val Leu Thr Lys Glu Gly Glu 
145                 150                 155                 160 


Gln Lys Trp Ser Leu Ile Gln Glu Ser Glu Phe Ile Asn Ser Thr Gly 
                165                 170                 175     


Gln Phe Gln Gly Leu Phe Thr Val Gly Pro Val Thr Pro Ser Gln Arg 
            180                 185                 190         


Trp Ile Phe Arg Cys Tyr Gly Tyr His Val Asn Ser Pro Gln Val Trp 
        195                 200                 205             


Ser Glu Pro Ser Asp Leu Leu Glu Ile His Val Ser Glu Ala Asp Gln 
    210                 215                 220                 


Pro Leu Arg Pro Ser Pro Asn Ile Ser Asp Pro Lys Thr Val Ser Gln 
225                 230                 235                 240 


Pro Gln Asn Tyr Thr Met Glu Asn Leu Ile Arg Met Gly Ala Ser Ile 
                245                 250                 255     


Leu Val Leu Val Leu Leu Gly Val Leu Leu Phe Glu Ala Gln His Ser 
            260                 265                 270         


Gln Arg Gln Thr Gln His Ala Ala Gly Arg Glu Ser Ser Ala Ser Phe 
        275                 280                 285             


Met Val Ala Asp Thr Trp Glu Ile Gln Ala Asp Gly Trp Met Cys His 
    290                 295                 300                 


Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
305                 310                 315                 320 


Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys 
                325                 330                 335     


Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly 
            340                 345                 350         


Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala 
        355                 360                 365             


Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr 
    370                 375                 380                 


Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr 
385                 390                 395                 400 


Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys 
                405                 410                 415     


Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu 
            420                 425                 430         


His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp 
        435                 440                 445             


Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr 
    450                 455                 460                 


Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser 
465                 470                 475                 480 


Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile 
                485                 490                 495     


Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu 
            500                 505                 510         


Lys His Thr Lys Lys Arg Gln Ile Tyr Pro Tyr Asp Val Pro Asp Tyr 
        515                 520                 525             


Ala 
    


<210> 84
<211> 876
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Met Ser Cys Thr Phe Thr Ala Leu Leu Arg Leu Gly Leu Thr Leu Ser 
1               5                   10                  15      


Leu Trp Ile Pro Val Leu Thr Gly Ser Leu Pro Lys Pro Ile Leu Arg 
            20                  25                  30          


Val Gln Pro Asp Ser Val Val Ser Arg Arg Thr Lys Val Thr Phe Leu 
        35                  40                  45              


Cys Glu Glu Thr Ile Gly Ala Asn Glu Tyr Arg Leu Tyr Lys Asp Gly 
    50                  55                  60                  


Lys Leu Tyr Lys Thr Val Thr Lys Asn Lys Gln Lys Pro Glu Asn Lys 
65                  70                  75                  80  


Ala Glu Phe Ser Phe Ser Asn Val Asp Leu Ser Asn Ala Gly Gln Tyr 
                85                  90                  95      


Arg Cys Ser Tyr Ser Thr Gln Tyr Lys Ser Ser Gly Tyr Ser Asp Leu 
            100                 105                 110         


Leu Glu Leu Val Val Thr Gly His Tyr Trp Thr Pro Ser Leu Leu Ala 
        115                 120                 125             


Gln Ala Ser Pro Val Val Thr Ser Gly Gly Tyr Val Thr Leu Gln Cys 
    130                 135                 140                 


Glu Ser Trp His Asn Asp His Lys Phe Ile Leu Thr Val Glu Gly Pro 
145                 150                 155                 160 


Gln Lys Leu Ser Trp Thr Gln Asp Ser Gln Tyr Asn Tyr Ser Thr Arg 
                165                 170                 175     


Lys Tyr His Ala Leu Phe Ser Val Gly Pro Val Thr Pro Asn Gln Arg 
            180                 185                 190         


Trp Ile Cys Arg Cys Tyr Ser Tyr Asp Arg Asn Arg Pro Tyr Val Trp 
        195                 200                 205             


Ser Pro Pro Ser Glu Ser Val Glu Leu Leu Val Ser Gly Asn Leu Gln 
    210                 215                 220                 


Lys Pro Thr Ile Lys Ala Glu Pro Gly Ser Val Ile Thr Ser Lys Arg 
225                 230                 235                 240 


Ala Met Thr Ile Trp Cys Gln Gly Asn Leu Asp Ala Glu Val Tyr Phe 
                245                 250                 255     


Leu His Asn Glu Lys Ser Gln Lys Thr Gln Ser Thr Gln Thr Leu Gln 
            260                 265                 270         


Glu Pro Gly Asn Lys Gly Lys Phe Phe Ile Pro Ser Val Thr Leu Gln 
        275                 280                 285             


His Ala Gly Gln Tyr Arg Cys Tyr Cys Tyr Gly Ser Ala Gly Trp Ser 
    290                 295                 300                 


Gln Pro Ser Asp Thr Leu Glu Leu Val Val Thr Gly Ile Tyr Glu Tyr 
305                 310                 315                 320 


Tyr Glu Pro Arg Leu Ser Val Leu Pro Ser Pro Val Val Thr Ala Gly 
                325                 330                 335     


Gly Asn Met Thr Leu His Cys Ala Ser Asp Phe Pro Tyr Asp Lys Phe 
            340                 345                 350         


Ile Leu Thr Lys Glu Asp Lys Lys Phe Gly Asn Ser Leu Asp Thr Glu 
        355                 360                 365             


His Ile Ser Ser Ser Gly Gln Tyr Arg Ala Leu Phe Ile Ile Gly Pro 
    370                 375                 380                 


Thr Thr Pro Thr His Thr Gly Ala Phe Arg Cys Tyr Gly Tyr Tyr Lys 
385                 390                 395                 400 


Asn Ala Pro Gln Leu Trp Ser Val Pro Ser Ala Leu Gln Gln Ile Leu 
                405                 410                 415     


Ile Ser Gly Leu Ser Lys Lys Pro Ser Leu Leu Thr His Gln Gly His 
            420                 425                 430         


Ile Leu Asp Pro Gly Met Thr Leu Thr Leu Gln Cys Phe Ser Asp Ile 
        435                 440                 445             


Asn Tyr Asp Arg Phe Ala Leu His Lys Val Gly Gly Ala Asp Ile Met 
    450                 455                 460                 


Gln His Ser Ser Gln Gln Thr Asp Thr Gly Phe Ser Val Ala Asn Phe 
465                 470                 475                 480 


Thr Leu Gly Tyr Val Ser Ser Ser Thr Gly Gly Gln Tyr Arg Cys Tyr 
                485                 490                 495     


Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Ser Ser Glu Pro Leu 
            500                 505                 510         


Asp Ile Leu Ile Thr Gly Gln Leu Pro Leu Thr Pro Ser Leu Ser Val 
        515                 520                 525             


Gln Pro Asn His Thr Val His Ser Gly Glu Thr Val Ser Leu Leu Cys 
    530                 535                 540                 


Trp Ser Met Asp Ser Val Asp Thr Phe Ile Leu Ser Lys Glu Gly Ser 
545                 550                 555                 560 


Ala Gln Gln Pro Leu Arg Leu Lys Ser Lys Ser His Asp Gln Gln Ser 
                565                 570                 575     


Gln Ala Glu Phe Ser Met Ser Ala Val Thr Ser His Leu Ser Gly Thr 
            580                 585                 590         


Tyr Arg Cys Tyr Gly Ala Gln Asp Ser Ser Phe Tyr Leu Leu Ser Ser 
        595                 600                 605             


Ala Ser Ala Pro Val Glu Leu Thr Val Ser Gly Pro Ile Glu Thr Ser 
    610                 615                 620                 


Thr Pro Pro Pro Thr Met Ser Met Pro Leu Gly Gly Leu His Met Tyr 
625                 630                 635                 640 


Leu Lys Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val 
                645                 650                 655     


Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser 
            660                 665                 670         


Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu 
        675                 680                 685             


Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser 
    690                 695                 700                 


Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val 
705                 710                 715                 720 


Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp 
                725                 730                 735     


Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val 
            740                 745                 750         


His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys 
        755                 760                 765             


Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys 
    770                 775                 780                 


Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu 
785                 790                 795                 800 


Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn 
                805                 810                 815     


Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile 
            820                 825                 830         


Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val 
        835                 840                 845             


Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys 
    850                 855                 860                 


Arg Gln Ile Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
865                 870                 875     


<210> 85
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Met Ile Ala Met Leu Thr Val Leu Leu Tyr Leu Gly Leu Ile Leu Glu 
1               5                   10                  15      


Pro Arg Thr Ala Val Gln Ala Gly His Leu Pro Lys Pro Ile Ile Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ala Ala Tyr Thr Ser Val Ile Thr Trp 
        35                  40                  45              


Cys Gln Gly Ser Trp Glu Ala Gln Tyr Tyr His Leu Tyr Lys Glu Lys 
    50                  55                  60                  


Ser Val Asn Pro Trp Asp Thr Gln Val Pro Leu Glu Thr Arg Asn Lys 
65                  70                  75                  80  


Ala Lys Phe Asn Ile Pro Ser Met Thr Thr Ser Tyr Ala Gly Ile Tyr 
                85                  90                  95      


Lys Cys Tyr Tyr Glu Ser Ala Ala Gly Phe Ser Glu His Ser Asp Ala 
            100                 105                 110         


Met Glu Leu Val Met Thr Gly Ala Tyr Glu Asn Pro Ser Leu Ser Val 
        115                 120                 125             


Tyr Pro Ser Ser Asn Val Thr Ser Gly Val Ser Ile Ser Phe Ser Cys 
    130                 135                 140                 


Ser Ser Ser Ile Val Phe Gly Arg Phe Ile Leu Ile Gln Glu Gly Lys 
145                 150                 155                 160 


His Gly Leu Ser Trp Thr Leu Asp Ser Gln His Gln Ala Asn Gln Pro 
                165                 170                 175     


Ser Tyr Ala Thr Phe Val Leu Asp Ala Val Thr Pro Asn His Asn Gly 
            180                 185                 190         


Thr Phe Arg Cys Tyr Gly Tyr Phe Arg Asn Glu Pro Gln Val Trp Ser 
        195                 200                 205             


Lys Pro Ser Asn Ser Leu Asp Leu Met Ile Ser Glu Thr Lys Asp Gln 
    210                 215                 220                 


Ser Ser Thr Pro Thr Glu Asp Gly Leu Glu Thr Tyr Gln Lys Ile Leu 
225                 230                 235                 240 


Ile Gly Val Leu Val Ser Phe Leu Leu Leu Phe Phe Leu Leu Leu Phe 
                245                 250                 255     


Leu Ile Leu Ile Gly Tyr Gln Tyr Gly His Lys Lys Lys Ala Asn Ala 
            260                 265                 270         


Ser Val Lys Asn Thr Gln Ser Glu Asn Asn Ala Glu Leu Asn Ser Trp 
        275                 280                 285             


Asn Pro Gln Asn Glu Asp Pro Gln Gly Ile Val Tyr Ala Gln Val Lys 
    290                 295                 300                 


Pro Ser Arg Leu Gln Lys Asp Thr Ala Cys Lys Glu Thr Gln Asp Val 
305                 310                 315                 320 


Thr Tyr Ala Gln Leu Cys Ile Arg Thr Gln Glu Gln Asn Asn Ser Ile 
                325                 330                 335     


Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys 
            340                 345                 350         


Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser 
        355                 360                 365             


Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys 
    370                 375                 380                 


Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr 
385                 390                 395                 400 


Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His 
                405                 410                 415     


His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe 
            420                 425                 430         


Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser 
        435                 440                 445             


Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn 
    450                 455                 460                 


Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val 
465                 470                 475                 480 


Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp 
                485                 490                 495     


Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu 
            500                 505                 510         


Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe 
        515                 520                 525             


Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val 
    530                 535                 540                 


Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile 
545                 550                 555                 560 


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                565                 


<210> 86
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Gln Leu Ala Ala Leu Gln Ala Asp Leu 
                85                  90                  95      


Met Asn Leu Arg Met Glu Leu Gln Ser Tyr Arg Gly Ser Ala Thr Pro 
            100                 105                 110         


Ala Ala Ala Gly Ala Pro Glu Leu Thr Ala Gly Val Lys Leu Leu Thr 
        115                 120                 125             


Pro Ala Ala Pro Arg Pro His Asn Ser Ser Arg Gly His Arg Asn Arg 
    130                 135                 140                 


Arg Ala Phe Gln Gly Pro Glu Glu Thr Glu Gln Asp Val Asp Leu Ser 
145                 150                 155                 160 


Ala Pro Pro Ala Pro Cys Leu Pro Gly Cys Arg His Ser Gln His Asp 
                165                 170                 175     


Asp Asn Gly Met Asn Leu Arg Asn Ile Ile Gln Asp Cys Leu Gln Leu 
            180                 185                 190         


Ile Ala Asp Ser Asp Thr Pro Thr Ile Arg Lys Gly Thr Tyr Thr Phe 
        195                 200                 205             


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Asn Ala Leu Glu Glu Lys 
    210                 215                 220                 


Glu Asn Lys Ile Val Val Arg Gln Thr Gly Tyr Phe Phe Ile Tyr Ser 
225                 230                 235                 240 


Gln Val Leu Tyr Thr Asp Pro Ile Phe Ala Met Gly His Val Ile Gln 
                245                 250                 255     


Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
            260                 265                 270         


Phe Arg Cys Ile Gln Asn Met Pro Lys Thr Leu Pro Asn Asn Ser Cys 
        275                 280                 285             


Tyr Ser Ala Gly Ile Ala Arg Leu Glu Glu Gly Asp Glu Ile Gln Leu 
    290                 295                 300                 


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Arg Asn Gly Asp Asp Thr 
305                 310                 315                 320 


Phe Phe Gly Ala Leu Lys Leu Leu 
                325             


<210> 87
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Met Gly Ala Arg Arg Leu Arg Val Arg Ser Gln Arg Ser Arg Asp Ser 
1               5                   10                  15      


Ser Val Pro Thr Gln Cys Asn Gln Thr Glu Cys Phe Asp Pro Leu Val 
            20                  25                  30          


Arg Asn Cys Val Ser Cys Glu Leu Phe His Thr Pro Asp Thr Gly His 
        35                  40                  45              


Thr Ser Ser Leu Glu Pro Gly Thr Ala Leu Gln Pro Gln Glu Gly Ser 
    50                  55                  60                  


Ala Leu Arg Pro Asp Val Ala Ile Ile Gln Ala Asp Gly Trp Met Cys 
65                  70                  75                  80  


His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
                85                  90                  95      


Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln 
            100                 105                 110         


Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro 
        115                 120                 125             


Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu 
    130                 135                 140                 


Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr 
145                 150                 155                 160 


Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn 
                165                 170                 175     


Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr 
            180                 185                 190         


Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp 
        195                 200                 205             


Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln 
    210                 215                 220                 


Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp 
225                 230                 235                 240 


Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser 
                245                 250                 255     


Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile 
            260                 265                 270         


Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys 
        275                 280                 285             


Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn 
    290                 295                 300                 


Arg Leu Gly Lys 
305             


<210> 88
<211> 286
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 
1               5                   10                  15      


Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 
            20                  25                  30          


Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 
        35                  40                  45              


Thr Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val 
    50                  55                  60                  


Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser 
65                  70                  75                  80  


Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu 
                85                  90                  95      


Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser 
            100                 105                 110         


Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val 
        115                 120                 125             


Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp 
    130                 135                 140                 


Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val 
145                 150                 155                 160 


His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys 
                165                 170                 175     


Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys 
            180                 185                 190         


Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu 
        195                 200                 205             


Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn 
    210                 215                 220                 


Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile 
225                 230                 235                 240 


Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val 
                245                 250                 255     


Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys 
            260                 265                 270         


Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        275                 280                 285     


<210> 89
<211> 365
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Met Ala Met Ala Phe Cys Pro Lys Asp Gln Tyr Trp Asp Ser Ser Arg 
1               5                   10                  15      


Lys Ser Cys Val Ser Cys Ala Leu Thr Cys Ser Gln Arg Ser Gln Arg 
            20                  25                  30          


Thr Cys Thr Asp Phe Cys Lys Phe Ile Asn Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Arg Tyr Tyr Asp His Leu Leu Gly Ala Cys Val Ser Cys Asp Ser Thr 
    50                  55                  60                  


Cys Thr Gln His Pro Gln Gln Cys Ala His Phe Cys Glu Lys Arg Pro 
65                  70                  75                  80  


Arg Ser Gln Ala Asn Leu Gln Pro Glu Leu Gly Arg Pro Gln Ala Gly 
                85                  90                  95      


Glu Val Glu Val Arg Ser Asp Asn Ser Gly Arg His Gln Gly Ser Glu 
            100                 105                 110         


His Gly Pro Gly Leu Arg Leu Ser Ser Asp Gln Leu Thr Leu Tyr Cys 
        115                 120                 125             


Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr 
    130                 135                 140                 


Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile 
145                 150                 155                 160 


Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln 
                165                 170                 175     


Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys 
            180                 185                 190         


Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr 
        195                 200                 205             


Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser 
    210                 215                 220                 


Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His 
225                 230                 235                 240 


Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp 
                245                 250                 255     


Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala 
            260                 265                 270         


Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro 
        275                 280                 285             


Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro 
    290                 295                 300                 


Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala 
305                 310                 315                 320 


Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu 
                325                 330                 335     


Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 
            340                 345                 350         


Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        355                 360                 365 


<210> 90
<211> 723
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Ala Ser Thr Arg Ala Lys Pro Thr Leu Pro Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Thr Val Val Ile Pro Gly Pro Gly Asp Ala Gln Val Ser Ile His 
            20                  25                  30          


Pro Arg Glu Ala Phe Leu Pro Gln Gly Gly Ser Val Gln Val Asn Cys 
        35                  40                  45              


Ser Ser Ser Cys Lys Glu Asp Leu Ser Leu Gly Leu Glu Thr Gln Trp 
    50                  55                  60                  


Leu Lys Asp Glu Leu Glu Ser Gly Pro Asn Trp Lys Leu Phe Glu Leu 
65                  70                  75                  80  


Ser Glu Ile Gly Glu Asp Ser Ser Pro Leu Cys Phe Glu Asn Cys Gly 
                85                  90                  95      


Thr Val Gln Ser Ser Ala Ser Ala Thr Ile Thr Val Tyr Ser Phe Pro 
            100                 105                 110         


Glu Ser Val Glu Leu Arg Pro Leu Pro Ala Trp Gln Gln Val Gly Lys 
        115                 120                 125             


Asp Leu Thr Leu Arg Cys His Val Asp Gly Gly Ala Pro Arg Thr Gln 
    130                 135                 140                 


Leu Ser Ala Val Leu Leu Arg Gly Glu Glu Ile Leu Ser Arg Gln Pro 
145                 150                 155                 160 


Val Gly Gly His Pro Lys Asp Pro Lys Glu Ile Thr Phe Thr Val Leu 
                165                 170                 175     


Ala Ser Arg Gly Asp His Gly Ala Asn Phe Ser Cys Arg Thr Glu Leu 
            180                 185                 190         


Asp Leu Arg Pro Gln Gly Leu Ala Leu Phe Ser Asn Val Ser Glu Ala 
        195                 200                 205             


Arg Ser Leu Arg Thr Phe Asp Leu Pro Ala Thr Ile Pro Lys Leu Asp 
    210                 215                 220                 


Thr Pro Asp Leu Leu Glu Val Gly Thr Gln Gln Lys Leu Phe Cys Ser 
225                 230                 235                 240 


Leu Glu Gly Leu Phe Pro Ala Ser Glu Ala Arg Ile Tyr Leu Glu Leu 
                245                 250                 255     


Gly Gly Gln Met Pro Thr Gln Glu Ser Thr Asn Ser Ser Asp Ser Val 
            260                 265                 270         


Ser Ala Thr Ala Leu Val Glu Val Thr Glu Glu Phe Asp Arg Thr Leu 
        275                 280                 285             


Pro Leu Arg Cys Val Leu Glu Leu Ala Asp Gln Ile Leu Glu Thr Gln 
    290                 295                 300                 


Arg Thr Leu Thr Val Tyr Asn Phe Ser Ala Pro Val Leu Thr Leu Ser 
305                 310                 315                 320 


Gln Leu Glu Val Ser Glu Gly Ser Gln Val Thr Val Lys Cys Glu Ala 
                325                 330                 335     


His Ser Gly Ser Lys Val Val Leu Leu Ser Gly Val Glu Pro Arg Pro 
            340                 345                 350         


Pro Thr Pro Gln Val Gln Phe Thr Leu Asn Ala Ser Ser Glu Asp His 
        355                 360                 365             


Lys Arg Ser Phe Phe Cys Ser Ala Ala Leu Glu Val Ala Gly Lys Phe 
    370                 375                 380                 


Leu Phe Lys Asn Gln Thr Leu Glu Leu His Val Leu Tyr Gly Pro Arg 
385                 390                 395                 400 


Leu Asp Glu Thr Asp Cys Leu Gly Asn Trp Thr Trp Gln Glu Gly Ser 
                405                 410                 415     


Gln Gln Thr Leu Lys Cys Gln Ala Trp Gly Asn Pro Ser Pro Lys Met 
            420                 425                 430         


Thr Cys Arg Arg Lys Ala Asp Gly Ala Leu Leu Pro Ile Gly Val Val 
        435                 440                 445             


Lys Ser Val Lys Gln Glu Met Asn Gly Thr Tyr Val Cys His Ala Phe 
    450                 455                 460                 


Ser Ser His Gly Asn Val Thr Arg Asn Val Tyr Leu Thr Val Leu Tyr 
465                 470                 475                 480 


His Ser Gln Asn Asn Asp Ile Ile Gln Ala Asp Gly Trp Met Cys His 
                485                 490                 495     


Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys 
            500                 505                 510         


Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys 
        515                 520                 525             


Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly 
    530                 535                 540                 


Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala 
545                 550                 555                 560 


Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr 
                565                 570                 575     


Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr 
            580                 585                 590         


Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys 
        595                 600                 605             


Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu 
    610                 615                 620                 


His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp 
625                 630                 635                 640 


Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr 
                645                 650                 655     


Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser 
            660                 665                 670         


Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile 
        675                 680                 685             


Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu 
    690                 695                 700                 


Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg 
705                 710                 715                 720 


Leu Gly Lys 
            


<210> 91
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Met Asp Ala Lys Val Val Ala Val Leu Ala Leu Val Leu Ala Ala Leu 
1               5                   10                  15      


Cys Ile Ser Asp Gly Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys 
            20                  25                  30          


Arg Phe Phe Glu Ser His Ile Ala Arg Ala Asn Val Lys His Leu Lys 
        35                  40                  45              


Ile Leu Asn Thr Pro Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys 
    50                  55                  60                  


Asn Asn Asn Arg Gln Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln 
65                  70                  75                  80  


Glu Tyr Leu Glu Lys Ala Leu Asn Lys Arg Leu Lys Met Ile Ile Gln 
                85                  90                  95      


Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp 
            100                 105                 110         


Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe 
        115                 120                 125             


Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln 
    130                 135                 140                 


Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala 
145                 150                 155                 160 


Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His 
                165                 170                 175     


Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile 
            180                 185                 190         


Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr 
        195                 200                 205             


Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu 
    210                 215                 220                 


Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe 
225                 230                 235                 240 


Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu 
                245                 250                 255     


Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu 
            260                 265                 270         


Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe 
        275                 280                 285             


Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly 
    290                 295                 300                 


Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr 
305                 310                 315                 320 


Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                325                 330 


<210> 92
<211> 377
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Met Gly Leu Asn Pro Gln Leu Val Val Ile Leu Leu Phe Phe Leu Glu 
1               5                   10                  15      


Cys Thr Arg Ser His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu 
            20                  25                  30          


Ile Ile Gly Ile Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr 
        35                  40                  45              


Glu Met Asp Val Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu 
    50                  55                  60                  


Ser Glu Leu Val Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys His Gly Lys Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met 
                85                  90                  95      


Glu Leu Gln Arg Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile 
            100                 105                 110         


Ser Cys Thr Met Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu 
        115                 120                 125             


Glu Ser Leu Lys Ser Ile Met Gln Met Asp Tyr Ser Ile Ile Gln Ala 
    130                 135                 140                 


Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe 
145                 150                 155                 160 


Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr 
                165                 170                 175     


Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly 
            180                 185                 190         


Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr 
        195                 200                 205             


Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val 
    210                 215                 220                 


Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn 
225                 230                 235                 240 


Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr 
                245                 250                 255     


Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly 
            260                 265                 270         


Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu 
        275                 280                 285             


His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser 
    290                 295                 300                 


Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val 
305                 310                 315                 320 


Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe 
                325                 330                 335     


Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile 
            340                 345                 350         


His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr 
        355                 360                 365             


Asp Ile Glu Met Asn Arg Leu Gly Lys 
    370                 375         


<210> 93
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 93
Met Lys Phe Leu Ser Ala Arg Asp Phe His Pro Val Ala Phe Leu Gly 
1               5                   10                  15      


Leu Met Leu Val Thr Thr Thr Ala Phe Pro Thr Ser Gln Val Arg Arg 
            20                  25                  30          


Gly Asp Phe Thr Glu Asp Thr Thr Pro Asn Arg Pro Val Tyr Thr Thr 
        35                  40                  45              


Ser Gln Val Gly Gly Leu Ile Thr His Val Leu Trp Glu Ile Val Glu 
    50                  55                  60                  


Met Arg Lys Glu Leu Cys Asn Gly Asn Ser Asp Cys Met Asn Asn Asp 
65                  70                  75                  80  


Asp Ala Leu Ala Glu Asn Asn Leu Lys Leu Pro Glu Ile Gln Arg Asn 
                85                  90                  95      


Asp Gly Cys Tyr Gln Thr Gly Tyr Asn Gln Glu Ile Cys Leu Leu Lys 
            100                 105                 110         


Ile Ser Ser Gly Leu Leu Glu Tyr His Ser Tyr Leu Glu Tyr Met Lys 
        115                 120                 125             


Asn Asn Leu Lys Asp Asn Lys Lys Asp Lys Ala Arg Val Leu Gln Arg 
    130                 135                 140                 


Asp Thr Glu Thr Leu Ile His Ile Phe Asn Gln Glu Val Lys Asp Leu 
145                 150                 155                 160 


His Lys Ile Val Leu Pro Thr Pro Ile Ser Asn Ala Leu Leu Thr Asp 
                165                 170                 175     


Lys Leu Glu Ser Gln Lys Glu Trp Leu Arg Thr Lys Thr Ile Gln Phe 
            180                 185                 190         


Ile Leu Lys Ser Leu Glu Glu Phe Leu Lys Val Thr Leu Arg Ser Thr 
        195                 200                 205             


Arg Gln Thr Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys 
    210                 215                 220                 


Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr 
225                 230                 235                 240 


His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser 
                245                 250                 255     


Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro 
            260                 265                 270         


Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val 
        275                 280                 285             


Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
    290                 295                 300                 


Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro 
305                 310                 315                 320 


Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly 
                325                 330                 335     


Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His Leu Ser 
            340                 345                 350         


Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser 
        355                 360                 365             


Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser 
    370                 375                 380                 


Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser 
385                 390                 395                 400 


Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe 
                405                 410                 415     


Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr 
            420                 425                 430         


Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
        435                 440                 445             


<210> 94
<211> 596
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 94
Met Asn Ala Pro Leu Gly Gly Ile Trp Leu Trp Leu Pro Leu Leu Leu 
1               5                   10                  15      


Thr Trp Leu Thr Pro Glu Val Asn Ser Ser Trp Trp Tyr Met Arg Ala 
            20                  25                  30          


Thr Gly Gly Ser Ser Arg Val Met Cys Asp Asn Val Pro Gly Leu Val 
        35                  40                  45              


Ser Ser Gln Arg Gln Leu Cys His Arg His Pro Asp Val Met Arg Ala 
    50                  55                  60                  


Ile Ser Gln Gly Val Ala Glu Trp Thr Ala Glu Cys Gln His Gln Phe 
65                  70                  75                  80  


Arg Gln His Arg Trp Asn Cys Asn Thr Leu Asp Arg Asp His Ser Leu 
                85                  90                  95      


Phe Gly Arg Val Leu Leu Arg Ser Ser Arg Glu Ser Ala Phe Val Tyr 
            100                 105                 110         


Ala Ile Ser Ser Ala Gly Val Val Phe Ala Ile Thr Arg Ala Cys Ser 
        115                 120                 125             


Gln Gly Glu Val Lys Ser Cys Ser Cys Asp Pro Lys Lys Met Gly Ser 
    130                 135                 140                 


Ala Lys Asp Ser Lys Gly Ile Phe Asp Trp Gly Gly Cys Ser Asp Asn 
145                 150                 155                 160 


Ile Asp Tyr Gly Ile Lys Phe Ala Arg Ala Phe Val Asp Ala Lys Glu 
                165                 170                 175     


Arg Lys Gly Lys Asp Ala Arg Ala Leu Met Asn Leu His Asn Asn Arg 
            180                 185                 190         


Ala Gly Arg Lys Ala Val Lys Arg Phe Leu Lys Gln Glu Cys Lys Cys 
        195                 200                 205             


His Gly Val Ser Gly Ser Cys Thr Leu Arg Thr Cys Trp Leu Ala Met 
    210                 215                 220                 


Ala Asp Phe Arg Lys Thr Gly Asp Tyr Leu Trp Arg Lys Tyr Asn Gly 
225                 230                 235                 240 


Ala Ile Gln Val Val Met Asn Gln Asp Gly Thr Gly Phe Thr Val Ala 
                245                 250                 255     


Asn Glu Arg Phe Lys Lys Pro Thr Lys Asn Asp Leu Val Tyr Phe Glu 
            260                 265                 270         


Asn Ser Pro Asp Tyr Cys Ile Arg Asp Arg Glu Ala Gly Ser Leu Gly 
        275                 280                 285             


Thr Ala Gly Arg Val Cys Asn Leu Thr Ser Arg Gly Met Asp Ser Cys 
    290                 295                 300                 


Glu Val Met Cys Cys Gly Arg Gly Tyr Asp Thr Ser His Val Thr Arg 
305                 310                 315                 320 


Met Thr Lys Cys Gly Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys 
                325                 330                 335     


Gln Asp Cys Leu Glu Ala Leu Asp Val His Thr Cys Lys Ala Pro Lys 
            340                 345                 350         


Asn Ala Asp Trp Thr Thr Ala Thr Ile Gln Ala Asp Gly Trp Met Cys 
        355                 360                 365             


His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
    370                 375                 380                 


Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln 
385                 390                 395                 400 


Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro 
                405                 410                 415     


Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu 
            420                 425                 430         


Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr 
        435                 440                 445             


Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn 
    450                 455                 460                 


Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr 
465                 470                 475                 480 


Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp 
                485                 490                 495     


Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln 
            500                 505                 510         


Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp 
        515                 520                 525             


Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser 
    530                 535                 540                 


Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile 
545                 550                 555                 560 


Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys 
                565                 570                 575     


Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn 
            580                 585                 590         


Arg Leu Gly Lys 
        595     


<210> 95
<211> 416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 95
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Arg Ser Gly Met Leu Asp Ser Asp Leu His Leu Ser 
305                 310                 315                 320 


Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser 
                325                 330                 335     


Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser 
            340                 345                 350         


Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser 
        355                 360                 365             


Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe 
    370                 375                 380                 


Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr 
385                 390                 395                 400 


Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                405                 410                 415     


<210> 96
<211> 546
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 96
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Asp Ile Ile Gln Ala Asp Gly Trp Met Cys His Ala 
305                 310                 315                 320 


Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr 
                325                 330                 335     


Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys 
            340                 345                 350         


Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe 
        355                 360                 365             


Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val 
    370                 375                 380                 


Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly 
385                 390                 395                 400 


Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile 
                405                 410                 415     


Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val 
            420                 425                 430         


Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser Asp Leu His 
        435                 440                 445             


Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala 
    450                 455                 460                 


Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly 
465                 470                 475                 480 


Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp 
                485                 490                 495     


Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly 
            500                 505                 510         


Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys 
        515                 520                 525             


His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu 
    530                 535                 540                 


Gly Lys 
545     


<210> 97
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 97
Met Gly Leu Ser Asn Ile Leu Phe Val Met Ala Phe Leu Leu Ser Gly 
1               5                   10                  15      


Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu 
            20                  25                  30          


Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val 
        35                  40                  45              


Val Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu 
    50                  55                  60                  


Gly Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr 
65                  70                  75                  80  


Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile 
                85                  90                  95      


Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr 
            100                 105                 110         


Gly Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
        115                 120                 125             


Asn Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn 
    130                 135                 140                 


Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro 
145                 150                 155                 160 


Lys Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr 
                165                 170                 175     


Asp Gly Ile Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp 
            180                 185                 190         


Val Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met 
        195                 200                 205             


Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser 
    210                 215                 220                 


Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile 
225                 230                 235                 240 


Pro Trp Ile Thr Ala Val Leu Asp Ile Ile Gln Ala Asp Gly Trp Met 
                245                 250                 255     


Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly 
            260                 265                 270         


Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu 
        275                 280                 285             


Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn 
    290                 295                 300                 


Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala 
305                 310                 315                 320 


Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu 
                325                 330                 335     


Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser 
            340                 345                 350         


Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp 
        355                 360                 365             


Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met Leu Asp Ser 
    370                 375                 380                 


Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile 
385                 390                 395                 400 


Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly 
                405                 410                 415     


Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe 
            420                 425                 430         


Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu 
        435                 440                 445             


Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile 
    450                 455                 460                 


Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
465                 470                 475                 480 


Asn Arg Leu Gly Lys 
                485 


<210> 98
<211> 502
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 98
Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Asp Ile Lys Leu Gln Gln Ser Gly 
            20                  25                  30          


Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Thr 
        35                  40                  45              


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
65                  70                  75                  80  


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr 
                85                  90                  95      


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
            100                 105                 110         


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
        115                 120                 125             


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Val 
    130                 135                 140                 


Glu Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Val 
145                 150                 155                 160 


Asp Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro 
                165                 170                 175     


Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr 
            180                 185                 190         


Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
        195                 200                 205             


Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
225                 230                 235                 240 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Val Ile Gln Ala Asp 
            260                 265                 270         


Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg 
        275                 280                 285             


Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro 
    290                 295                 300                 


Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr 
305                 310                 315                 320 


Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val 
                325                 330                 335     


Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu 
            340                 345                 350         


Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly 
        355                 360                 365             


Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp 
    370                 375                 380                 


His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Gly Met 
385                 390                 395                 400 


Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His 
                405                 410                 415     


Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu 
            420                 425                 430         


Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu 
        435                 440                 445             


Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile 
    450                 455                 460                 


Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His 
465                 470                 475                 480 


Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Pro Tyr 
                485                 490                 495     


Asp Val Pro Asp Tyr Ala 
            500         


<210> 99
<211> 220
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 99
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Met Val Ser His Arg Tyr Pro Arg Ile 
                85                  90                  95      


Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
            100                 105                 110         


Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn 
        115                 120                 125             


Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly 
    130                 135                 140                 


Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
145                 150                 155                 160 


Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met 
                165                 170                 175     


Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
            180                 185                 190         


Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile 
        195                 200                 205             


Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
    210                 215                 220 


<210> 100
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 100
Met Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Asn Pro Asn Gln 
1               5                   10                  15      


Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val Thr Gly Ile Val Ser 
            20                  25                  30          


Leu Met Leu Gln Ile Gly Asn Met Ile Ser Ile Trp Val Ser His Ser 
        35                  40                  45              


Ile His Thr Gly Asn Gln His Gln Ser Glu Pro Ile Ser Asn Thr Asn 
    50                  55                  60                  


Phe Leu Thr Glu Lys Ala Val Ala Ser Val Lys Leu Ala Gly Asn Ser 
65                  70                  75                  80  


Ser Leu Cys Pro Ile Asn Asp Ala Cys Pro Trp Ala Val Ser Gly Ala 
                85                  90                  95      


Arg Ala Ser Pro Gly Ser Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro 
            100                 105                 110         


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
        115                 120                 125             


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
    130                 135                 140                 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
145                 150                 155                 160 


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
                165                 170                 175     


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
            180                 185                 190         


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
        195                 200                 205             


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
    210                 215                 220                 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
225                 230                 235                 240 


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
                245                 250                 255     


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
            260                 265                 270         


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
        275                 280                 285             


Pro Arg Ser Glu 
    290         


