                     Sequence Listing - Rectification - Rule 13ter

<110>  CURIA IP HOLDINGS, LLC
 
<120>  SARS-COV-2 SPIKE PROTEIN ANTIBODIES

<130>  147471.002101

<140>  PCT/US2022/029705
<141>  2022-05-17

<150>  63/189,635
<151>  2021-05-17

<150>  63/317,441
<151>  2022-03-07

<150>  63/216,406
<151>  2021-06-29

<160>  522   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B16-B Heavy Chain  CDR1

<400>  1

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B16-B Heavy Chain CDR2

<400>  2

Ile Tyr Ile Gly Asn Gly Tyr Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B16-B Heavy Chain CDR3

<400>  3

Ala Arg Asp Gly Thr Arg Asp Ala Met Asp Tyr 
1               5                   10      


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B16-B Light Chain CDR1

<400>  4

Glu Asn Ile Tyr Ser Asn 
1               5       


<210>  5
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-B16-B Light Chain CDR2

<400>  5
aat                                                                      3


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B16-B Light Chain CDR3

<400>  6

Gln His Phe Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B16-B Heavy Chain

<400>  7

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Ile Gly Asn Gly Tyr Thr Ala Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Thr Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  8
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-B16-B Heavy Chain

<400>  8
gaggtccagc ttcagcagtc tggagctgag ctggtgaggc ctgggtcctc agtgaaaatg       60

tcctgcaaga cttctggata tacattcaca agctacggta taaactgggt gaagcagagg      120

cctggacagg gcctggaatg gattggatat atttatattg gaaatggtta tactgcgtac      180

aatgagaagt tcaagggcaa ggccacactg acttcagaca catcctccag cacagcctac      240

atgcagctca gcagtctgac atctgaggac tctgcaatct atttctgtgc aagagacggt      300

actagggatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B16-B Light Chain

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-B16-B Light Chain

<400>  10
gacatccaaa tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga aaatatttac agtaatttag catggtatca gcagaaacag      120

ggaaaatctc ctcaactcct ggtctatgct gcaacaaatt tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat ttttatagta gtccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Heavy Chain CDR1

<400>  11

Gly Tyr Thr Phe Thr Thr Tyr Gly 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Heavy Chain CDR2

<400>  12

Ile Asn Thr Phe Ser Gly Leu Pro 
1               5               


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Heavy Chain CDR3

<400>  13

Ala Arg Val Lys Val His Asp Tyr Asp Gly Asp Phe Tyr Gly Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Light Chain CDR1

<400>  14

Lys Ser Leu Leu Asn Ser Asp Gly Phe Thr Tyr 
1               5                   10      


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Light Chain CDR2

<400>  15

Leu Val Ser 
1           


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Light Chain CDR3

<400>  16

Phe Gln Ser Asn Tyr Leu Pro Leu Thr 
1               5                   


<210>  17
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Heavy Chain

<400>  17

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Phe Ser Gly Leu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Asn Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Lys Val His Asp Tyr Asp Gly Asp Phe Tyr Gly Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  18
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-B20-A Heavy Chain

<400>  18
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaaaatc       60

tcctgcaagg cttctggata taccttcaca acctatggaa tgagctgggt gaaacaggca      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct tctctggact gccaacatat      180

gctgatgact tcaacggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa agatgaggac acggcgacat atttctgtgc aagagtgaag      300

gttcatgatt acgacgggga tttctatggt atggactact ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-B20-A Light Chain

<400>  19

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Asn Ile Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Lys Ser Thr Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Gly Phe Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ser 
                85                  90                  95      


Asn Tyr Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  20
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-B20-A Light Chain

<400>  20
gatgttgttc tgacccaaac tccactctct ctgcctgtca atattggaga tcaagcctct       60

atctcttgca agtctactaa gagtcttctg aatagtgatg gattcactta tttggactgg      120

tacctgcaga agccaggcca gtctccacag ctcctaatat atttggtttc taatcgattt      180

tctggagttc cagacaggtt cagtggcagt gggtcaggaa cagatttcac actcaagatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct tccagagtaa ctatcttcct      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  21

<400>  21
000

<210>  22

<400>  22
000

<210>  23

<400>  23
000

<210>  24

<400>  24
000

<210>  25

<400>  25
000

<210>  26

<400>  26
000

<210>  27

<400>  27
000

<210>  28

<400>  28
000

<210>  29

<400>  29
000

<210>  30

<400>  30
000

<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Heavy Chain CDR1

<400>  31

Gly Tyr Thr Phe Thr Asp Cys Glu 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Heavy Chain CDR2

<400>  32

Ile Asp Pro Glu Thr Gly Asp Thr 
1               5               


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Heavy Chain CDR3

<400>  33

Thr Arg Arg Arg Asp Tyr Gly Asn Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Light Chain CDR1

<400>  34

Ser Ser Ile Ser Ser Ser Asn 
1               5           


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Light Chain CDR2

<400>  35

Gly Thr Ser 
1           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Light Chain CDR3

<400>  36

Gln Gln Trp Thr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  37
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Heavy Chain

<400>  37

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Cys 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Arg Asp Tyr Gly Asn Pro Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-O15-A Heavy Chain

<400>  38
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttcgggcta cacatttact gactgtgaaa tgcactgggt gaagcagacc      120

cctgtgcatg gcctggaatg gattggagtt attgatcctg aaactggtga tactgcctac      180

aatcagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgccgtct attactgtac aagacgcagg      300

gactatggta acccctactg gtacttcgat gtctggggcg cagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  39
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O15-A Light Chain

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  40
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-O15-A Light Chain

<400>  40
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagctc aagtataagt tccagcaact tacactggta ccagcagaag      120

tcaggaacct cccccaaacc ctggatttat ggcacatcca accttgcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggacta gttacccata tacgttcgga      300

tcggggacca agctggaaat aaaa                                             324


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Heavy Chain CDR1

<400>  41

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Heavy Chain CDR2

<400>  42

Ile Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Heavy Chain CDR3

<400>  43

Ala Arg Glu Ala Tyr Arg Tyr Phe Asp Val 
1               5                   10  


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Light Chain CDR1

<400>  44

Glu Asn Ile Tyr Ser Asn 
1               5       


<210>  45
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Light Chain CDR2

<400>  45

Gly Ala Thr 
1           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Light Chain CDR3

<400>  46

Gln His Phe Trp Gly Ile Pro Trp Thr 
1               5                   


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Heavy Chain

<400>  47

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Arg Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  48
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-K11-A Heavy Chain

<400>  48
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact agctatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactgagtac      180

aatgagaaat tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct atcactgtgc aagagaggcc      300

taccggtact tcgatgtctg gggcacaggg accacggtca ccgtctcctc a               351


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-K11-A Light Chain

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Tyr Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Phe Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  50
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-K11-A Light Chain

<400>  50
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaatatttac agtaatttag catggtatca gcagaaacag      120

ggaaaatatc ctcagctcct ggtctatggt gcaacaaact tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag tatttcctca agatcaacag cctgcagtct      240

gaagattttg ggagttatta ctgtcaacat ttttggggta ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Heavy Chain CDR1

<400>  51

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Heavy Chain CDR2

<400>  52

Ile Trp Ser Gly Gly Ile Thr 
1               5           


<210>  53
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Heavy Chain CDR3

<400>  53

Ala Arg Ile Ile Thr Thr Val Leu Asp Gln Phe Ala Asp 
1               5                   10              


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Light Chain CDR1

<400>  54

Gln Ser Val Ser Thr Ser Thr Tyr Ser Tyr 
1               5                   10  


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Light Chain CDR2

<400>  55

Tyr Ala Ser 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Light Chain CDR3

<400>  56

Gln His Ser Trp Glu Ile Pro Pro Thr 
1               5                   


<210>  57
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Heavy Chain

<400>  57

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ile Thr Asp Tyr Asn Ala Gly Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Thr Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ile Ile Thr Thr Val Leu Asp Gln Phe Ala Asp Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  58
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-P17-A Heavy Chain

<400>  58
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtg atatggagtg gtggaatcac agactataat      180

gcaggtttca tatccagact gagcatcagc aaggacaatt ccaagagcca agttttcttt      240

acaatgaaca gtctgcaagc tgatgacaca gccatatatt actgtgccag gattattact      300

acggttctag atcagtttgc tgactggggc caagggactc tggtcactgt ctctgca         357


<210>  59
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-P17-A Light Chain

<400>  59

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Thr Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  60
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-P17-A Light Chain

<400>  60
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctacct atagttatat tcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattcctccc      300

acgttcggtg ctgggaccaa gctggagctg aaa                                   333


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Heavy Chain CDR1

<400>  61

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Heavy Chain CDR2

<400>  62

Ile Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Heavy Chain CDR3

<400>  63

Ala Arg Glu Ala Tyr Arg Tyr Phe Asp Val 
1               5                   10  


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Light Chain CDR1

<400>  64

Glu Asn Ile Tyr Ser Asn 
1               5       


<210>  65
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Light Chain CDR2

<400>  65

Ala Ala Thr 
1           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Light Chain CDR3

<400>  66

Gln His Phe Trp Gly Thr Pro Trp Thr 
1               5                   


<210>  67
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Heavy Chain

<400>  67

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Tyr Arg Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  68
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-A22-A Heavy Chain

<400>  68
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact agctatgtta tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactgagtac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagagaggcc      300

taccggtact tcgatgtctg gggcacaggg accacggtca ccgtctcctc a               351


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A22-A Light Chain

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  70
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-A22-A Light Chain

<400>  70
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaatatttac agtaatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctatgct gcaacaaact tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag tattccctca agatcaacag cctgcagtct      240

gaagattttg ggagttatta ctgtcaacat ttttggggta ctccgtggac gttcggtgga      300

ggcaccaaac tggaaatcaa a                                                321


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Heavy Chain CDR1

<400>  71

Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Heavy Chain CDR2

<400>  72

Ile Ser Ser Gly Gly Gly Phe Thr 
1               5               


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Heavy Chain CDR3

<400>  73

Ala Arg Arg Leu Tyr Asp Tyr Asp Trp Phe Ala Tyr 
1               5                   10          


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Light Chain CDR1

<400>  74

Gln Asp Val Val Thr Ala 
1               5       


<210>  75
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Light Chain CDR2

<400>  75

Trp Ala Ser 
1           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Light Chain CDR3

<400>  76

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  77
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Heavy Chain

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Leu Tyr Asp Tyr Asp Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  78
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-C22-A Heavy Chain

<400>  78
gaggtgcagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtggtggttt cacctactat      180

ccagacagtg tggaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacggctc      300

tatgattacg actggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  79
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C22-A Light Chain

<400>  79

Asp Ile Val Met Thr Gln Ser His Lys Ile Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Val Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Lys Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  80
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-C22-A Light Chain

<400>  80
gacattgtga tgacccagtc tcacaaaatc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtggtt actgctgtag cctggtatca aaagaaacca      120

gggcaatctc ctaaactact gattcattgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atcctctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Heavy Chain CDR1

<400>  81

Gly Tyr Ala Phe Ile Ser His Trp 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Heavy Chain CDR2

<400>  82

Ile Asp Pro Asn Ser Ser Gly Ser 
1               5               


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Heavy Chain CDR3

<400>  83

Ala Arg Ser Pro Tyr Tyr Ser Asn Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Light Chain CDR1

<400>  84

Ser Ser Ile Ser Ser Ser Asn 
1               5           


<210>  85
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Light Chain CDR2

<400>  85

Gly Thr Ser 
1           


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Light Chain CDR3

<400>  86

Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  87
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Heavy Chain

<400>  87

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ile Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Ser Ser Gly Ser Lys Asp Asn Glu Lys Phe 
    50                  55                  60                  


Arg Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Tyr Tyr Ser Asn Pro Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  88
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-O14-B Heavy Chain

<400>  88
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta cgccttcatt agccactgga tgcactgggt gaggcagagg      120

cctggacgag gccttgagtg gattggaagg attgatccta atagtagtgg ttctaaagat      180

aatgagaagt tcaggagcaa ggccacactg actgtagaca aaccctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagatccccc      300

tactatagta acccttactg gtacttcgat gtctggggcg cagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210>  89
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-O14-B Light Chain

<400>  89

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Thr Asn Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  90
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-O14-B Light Chain

<400>  90
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagttc aagtataagt tccagcaact tgcactggta ccagcagaag      120

tcagaaacct cccccaaacc ctggatttat ggcacatcca acctggcttc tggagtcccg      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcac caacatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttatccatt cacgttcggc      300

tcggggacaa agttggaaat aaaa                                             324


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Heavy Chain CDR1

<400>  91

Gly Asn Thr Phe Thr Thr Ala Gly 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Heavy Chain CDR2

<400>  92

Ile Asn Thr His Ser Gly Glu Pro 
1               5               


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Heavy Chain CDR3

<400>  93

Ala Arg Tyr Gly Asp Tyr Tyr Tyr Phe Asp Cys 
1               5                   10      


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Light Chain CDR1

<400>  94

Gly Asn Ile His Asn Tyr 
1               5       


<210>  95
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Light Chain CDR2

<400>  95

Asn Ala Lys 
1           


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Light Chain CDR3

<400>  96

Gln His Phe Trp Thr Thr Pro Trp Ser 
1               5                   


<210>  97
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Heavy Chain

<400>  97

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Val Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Gly Asp Tyr Tyr Tyr Phe Asp Cys Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  98
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-C19-A Heavy Chain

<400>  98
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggaa taccttcaca actgctggaa tgcagtgggt gcaaaagatg      120

ccaggaaagg gttttaagtg gattggctgg ataaacaccc actctggaga gccaaaatat      180

gcagaagact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttacagataa gcaacctcaa aaatgaggac acggctacgt atttctgtgc gagatatggt      300

gattactact actttgactg ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  99
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A Light Chain

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Phe Tyr Cys Gln His Phe Trp Thr Thr Pro Trp 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  100
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-C19-A Light Chain

<400>  100
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      240

gaagattttg ggagttttta ctgtcaacat ttttggacga ctccgtggtc gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Heavy Chain CDR1

<400>  101

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Heavy Chain CDR2

<400>  102

Ile Asn Pro Asn Asn Gly Gly Ile 
1               5               


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Heavy Chain CDR3

<400>  103

Ala Arg Arg Gln Val Phe Tyr Asp Gly Tyr Tyr Asp Tyr Ala Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Light Chain CDR1

<400>  104

Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr 
1               5                   10  


<210>  105
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Light Chain CDR2

<400>  105

Tyr Ala Ser 
1           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Light Chain CDR3

<400>  106

Gln His Asn Trp Glu Ile Pro Pro Thr 
1               5                   


<210>  107
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Heavy Chain

<400>  107

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Gln Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Ile Arg Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Glu Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gln Val Phe Tyr Asp Gly Tyr Val Asp Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  108
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-N1-A Heavy Chain

<400>  108
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gcagcagagc      120

catggaaaga gccttgagtg gattggtgat attaatccta acaatggtgg tattcgctac      180

aaccagaact tcaagggcaa ggccacattg actgtagaga agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagaaggcag      300

gtattctatg atggttacta cgactatgct atggactatt ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  109
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-N1-A Light Chain

<400>  109

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Phe Cys Gln His Asn Trp 
                85                  90                  95      


Glu Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  110
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-N1-A Light Chain

<400>  110
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaagatac tgcaacatat ttctgtcagc acaattggga gattcctccc      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  111

<400>  111
000

<210>  112

<400>  112
000

<210>  113

<400>  113
000

<210>  114

<400>  114
000

<210>  115

<400>  115
000

<210>  116

<400>  116
000

<210>  117

<400>  117
000

<210>  118

<400>  118
000

<210>  119

<400>  119
000

<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
000

<210>  123

<400>  123
000

<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Heavy Chain CDR1

<400>  131

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Heavy Chain CDR2

<400>  132

Ile Asp Pro Glu Thr Gly Asp Thr 
1               5               


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Heavy Chain CDR3

<400>  133

Ala Arg Arg Arg Asp Tyr Gly Asn Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Light Chain CDR1

<400>  134

Ser Ser Ile Ser Ser Ser Asn 
1               5           


<210>  135
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Light Chain CDR2

<400>  135

Gly Thr Ser 
1           


<210>  136
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Light Chain CDR3

<400>  136

Gln Gln Trp Ser Asn Tyr Pro Tyr Thr 
1               5                   


<210>  137
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Heavy Chain

<400>  137

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Asp Tyr Gly Asn Pro Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Ala Val Thr Val Ser Ser 
        115                 120         


<210>  138
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-G24-A Heavy Chain

<400>  138
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttcgggcta cacatttact gactatgaaa tgcactgggt gaagcagaca      120

cctgtgcatg gcctggaatg gattggagtt attgatcctg aaactggtga tactgcctac      180

aatcagaagt tcaaggacaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgccgtct attactgtgc aagacgcagg      300

gactatggta acccctactg gtacttcgat gtctggggcg cagggaccgc ggtcaccgtc      360

tcctca                                                                 366


<210>  139
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-G24-A Light Chain

<400>  139

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Val Cys Gln Gln Trp Ser Asn Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  140
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-G24-A Light Chain

<400>  140
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgccagctc aagtataagt tccagcaact tacactggta ccagcagaag      120

tcaggaacct cccccaaacc ctggatttat ggcacatcca accttgcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta attacccata tacgttcgga      300

tcggggacca agttggagat taaa                                             324


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Heavy Chain CDR1

<400>  141

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Heavy Chain CDR2

<400>  142

Ile Ser Ser Gly Gly Gly Tyr Thr 
1               5               


<210>  143
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Heavy Chain CDR3

<400>  143

Ala Arg Pro Leu Ile Pro Thr Met Val Glu Ala Phe Asp Tyr 
1               5                   10                  


<210>  144
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Light Chain CDR1

<400>  144

Gln Ser Val Gly Asn Asn 
1               5       


<210>  145
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Light Chain CDR2

<400>  145

Tyr Ala Ser 
1           


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Light Chain CDR3

<400>  146

Gln Gln His Tyr Ser Ser Pro Phe Thr 
1               5                   


<210>  147
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Heavy Chain

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Thr Thr Ile Ser Ser Gly Gly Gly Tyr Thr Tyr Val Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu His Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Leu Ile Pro Thr Met Val Glu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Leu Thr Val Ser Ser 
        115                 120     


<210>  148
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-M12-A Heavy Chain

<400>  148
gaggtgcagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtacag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcacaacc attagtagtg gtggtggtta cacctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcacatga gcagtctgaa gtctgaggac acagccatgt atttctgtgc aagacccctt      300

attcctacga tggtagaagc atttgactac tggggccaag gcacctctct cacagtctcc      360

tca                                                                    363


<210>  149
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-M12-A Light Chain

<400>  149

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Pro Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Lys Ala Ser Gln Ser Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Val 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Thr Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  150
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-M12-A Light Chain

<400>  150
agtattgtga tgacccagac tcccaaattc ctgcctgtat cagcaggaga cagggttacc       60

atgacctgca aggccagtca gagtgtgggt aataatgtag cctggtacca acagaagcca      120

ggacagtctc ctaaactgct gatatactat gcatccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggatc tggggcagat ttcactttca ccatcagcag tgtgcaggtt      240

gaagacctgg cagtttattt ctgtcagcag cattatagct ctccattcac gttcggcacg      300

gggacaaaat tggaaataaa a                                                321


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Heavy Chain CDR1

<400>  151

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Heavy Chain CDR2

<400>  152

Ile Ser Gly Gly Gly Gly Phe Thr 
1               5               


<210>  153
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Heavy Chain CDR3

<400>  153

Ala Arg Asp Glu Asp Gly Lys His Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  154
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Light Chain CDR1

<400>  154

Gln Asp Val Gly Thr Ala 
1               5       


<210>  155
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Light Chain CDR2

<400>  155

Trp Ala Ser 
1           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Light Chain CDR3

<400>  156

Gln Gln Tyr Ala Ser Tyr Pro Leu Thr 
1               5                   


<210>  157
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Heavy Chain

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Asn Pro Ala Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Asp Gly Lys His 
            100                 


<210>  158
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-J24-A Heavy Chain

<400>  158
gaagtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagaat      120

ccggcgaaga ggctggagtg ggtcgcaacc attagcggtg gtggtggttt cacctactat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctatac      240

ctgcaaatga acagtctgag gtctgaggac acagccatgt attactgtgc aagggatgaa      300

gatggtaaac acgactactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  159
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-J24-A Light Chain

<400>  159

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ala Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Val Ile Lys 
            100                 105         


<210>  160
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-J24-A Light Chain

<400>  160
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccathagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tatgctagct atcctctgac gttcggtgga      300

ggcaccaagc tggtaatcaa a                                                321


<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Heavy Chain CDR1

<400>  161

Gly Tyr Thr Phe Thr Asp His Tyr 
1               5               


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Heavy Chain CDR2

<400>  162

Ile Phe Pro Gly Ser Gly Ser Thr 
1               5               


<210>  163
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Heavy Chain CDR3

<400>  163

Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr 
1               5                   10          


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Light Chain CDR1

<400>  164

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  165
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Light Chain CDR2

<400>  165

Tyr Thr Ser 
1           


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Light Chain CDR3

<400>  166

Gln Gln Val Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  167
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Heavy Chain

<400>  167

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Ser Thr Tyr Tyr Asn Glu Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  168
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-B11-A Heavy Chain

<400>  168
caggtccagc tacagcagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggcta caccttcact gaccactata taaattgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttttcctg gaagtggtag tacttactac      180

aatgagcagt tcaagggcaa ggccacgctt actgtagaca aatcctccaa cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagatcaggg      300

ggattacgac tggggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  169
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-B11-A Light Chain

<400>  169

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ser Thr Tyr Phe Cys Gln Gln Val Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  170
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-B11-A Light Chain

<400>  170
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattt ccacttactt ttgccaacag gttaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  171
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Heavy Chain CDR1

<400>  171

Gly Phe Thr Phe Asn Asn Tyr Trp 
1               5               


<210>  172
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Heavy Chain CDR2

<400>  172

Met Arg Leu Lys Ser Asp Asn Tyr Ala Thr 
1               5                   10  


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Heavy Chain CDR3

<400>  173

Ile Glu Gly Tyr Trp Thr Tyr 
1               5           


<210>  174
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Light Chain CDR1

<400>  174

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  175
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Light Chain CDR2

<400>  175

Ser Thr Ser 
1           


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Light Chain CDR3

<400>  176

Leu Gln Tyr His Arg Ser Pro Pro Tyr Thr 
1               5                   10  


<210>  177
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Heavy Chain

<400>  177

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Met Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Ile Glu Gly Tyr Trp Thr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  178
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-L10-A Heavy Chain

<400>  178
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcctgtgttg cctctggatt cactttcaat aactactgga tgaactgggt ccgccagtct      120

ccagagaagg ggcttgagtg ggttgctcaa atgagattga aatctgataa ttatgcaaca      180

cattatgcgg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt      240

gtctatctgc aaatgaacaa cttaagggct gaagacactg gaatttatta ctgtattgaa      300

ggttactgga cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  179
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-L10-A Light Chain

<400>  179

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Asn Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  180
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain Nucleotide Sequence of 1-L10-A

<400>  180

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Asn Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  181
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Heavy Chain CDR1

<400>  181

Gly Tyr Thr Phe Thr Gly Tyr Thr 
1               5               


<210>  182
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Heavy Chain CDR2

<400>  182

Ile Tyr Pro Glu Asn Gly Asp Thr 
1               5               


<210>  183
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Heavy Chain CDR3

<400>  183

Ala Arg Asp Gly Tyr Asp Val Leu Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Light Chain CDR1

<400>  184

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  185
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Light Chain CDR2

<400>  185

Leu Ala Ser 
1           


<210>  186
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Light Chain CDR3

<400>  186

Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  187
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Heavy Chain

<400>  187

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Glu Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Asp Val Leu Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  188
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-H7-A Heavy Chain

<400>  188
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc ggttacacta tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag aaaatggtga tacttcctac      180

aatcagaagt tcaagggcaa ggccacactg actgtcgaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagatggt      300

tacgacgttc tctatggtat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  189
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-H7-A Light Chain

<400>  189

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105                 110     


<210>  190
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-H7-A Light Chain

<400>  190
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtgg      300

acgttcggtg gaggcaccaa gctggatatc aaa                                   333


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Heavy Chain CDR1

<400>  191

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Heavy Chain CDR2

<400>  192

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  193
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Heavy Chain CDR3

<400>  193

Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Phe 
    


<210>  194
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Light Chain CDR1

<400>  194

Glu Asn Ile Tyr Ser His 
1               5       


<210>  195
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Light Chain CDR2

<400>  195

Asn Thr Lys 
1           


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Light Chain CDR3

<400>  196

Gln His His Tyr Gly Ile Pro Pro Glu 
1               5                   


<210>  197
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Heavy Chain

<400>  197

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  198
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-J9-A Heavy Chain

<400>  198
gaggtccagc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tacactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgg tactgactac      180

aaccagaagt tccagggcaa ggccacattg actgtaaaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atcggaagat tctgcagtct attactgtgc aagagggggg      300

ttttatggca attacggggc ttactatggt atggacttct ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  199
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-J9-A Light Chain

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Thr Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Pro 
                85                  90                  95      


Glu Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  200
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-J9-A Light Chain

<400>  200
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttat agtcatttag catggtatca gcagacacag      120

ggaaaatctc ctcagctcct ggtctataat acaaaaacct tagcagaagg tgtgccatca      180

aggttcactg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat cattatggta ttcctccgga gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  201
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Heavy Chain CDR1

<400>  201

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  202
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Heavy Chain CDR2

<400>  202

Ile Asn Ser Asn Asn Gly Gly Thr 
1               5               


<210>  203
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Heavy Chain CDR3

<400>  203

Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr 
1               5                   10              


<210>  204
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Light Chain CDR1

<400>  204

Glu Ser Val Asp Asn Ser Gly Ile Ser Phe 
1               5                   10  


<210>  205
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Light Chain CDR2

<400>  205

Ala Ala Ser 
1           


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Light Chain CDR3

<400>  206

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  207
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Heavy Chain

<400>  207

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Ser Asn Asn Gly Gly Thr Thr Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  208
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-O12-A Heavy Chain

<400>  208
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcctc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaattcta acaatggtgg tactacctac      180

gaccagaagt tcaagggcaa ggccactttg actgtagaca ggtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aaggagaggg      300

gatggtcact ttggggggtt tacttattgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  209
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-O12-A Light Chain

<400>  209

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  210
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-O12-A Light Chain

<400>  210
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  211
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Heavy Chain CDR1

<400>  211

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  212
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Heavy Chain CDR2

<400>  212

Ile Tyr Ile Gly Asn Gly Tyr Thr 
1               5               


<210>  213
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Heavy Chain CDR3

<400>  213

Ala Arg Gly Gly Val Asp Tyr 
1               5           


<210>  214
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Light Chain CDR1

<400>  214

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  215
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Light Chain CDR2

<400>  215

Lys Val Ser 
1           


<210>  216
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Light Chain CDR3

<400>  216

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  217
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Heavy Chain

<400>  217

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Ile Gly Asn Gly Tyr Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  218
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-P2-A Heavy Chain

<400>  218
gaggtccagc ttcagcagtc tggagctgag ctggtgaggc ctgggtcctc agtgaagatg       60

tcctgcaaga cttctggata tacattcaca agctacggta taaactgggt gaagcagagg      120

cctggacagg gcctggaatg gattggatat atttatattg gaaatggtta tactgaatac      180

aatgagaagt tcaagggtaa ggccacactg acttcagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcaatct atttctgtgc aagaggaggg      300

gttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  219
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-P2-A Light Chain

<400>  219

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  220
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-P2-A Light Chain

<400>  220
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  221
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Heavy Chain CDR1

<400>  221

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  222
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Heavy Chain CDR2

<400>  222

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  223
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Heavy Chain CDR3

<400>  223

Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Phe 
    


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Light Chain CDR1

<400>  224

Glu Asn Ile Tyr Ser His 
1               5       


<210>  225
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Light Chain CDR2

<400>  225

Asn Ala Lys 
1           


<210>  226
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Light Chain CDR3

<400>  226

Gln His His Tyr Gly Ile Pro Pro Glu 
1               5                   


<210>  227
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Heavy Chain

<400>  227

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  228
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-E13-A Heavy Chain

<400>  228
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tacactgggt gaaacagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgg tactgactac      180

aaccagaagt tccagggcaa ggccacattg actgtaaaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atcggaagat tttgcagtct attactgtgc aagagggggg      300

ttttatggca attacggggc ttactatggt atggacttct ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  229
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E13-A Light Chain

<400>  229

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Pro 
                85                  90                  95      


Glu Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  230
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-E13-A Light Chain

<400>  230
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttat agtcatttag catggtatca gcagacacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacat ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat cattatggta ttcctccgga gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  231
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Heavy Chain CDR1

<400>  231

Gly Asn Ala Phe Ser Ser Tyr Trp 
1               5               


<210>  232
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Heavy Chain CDR2

<400>  232

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  233
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Heavy Chain CDR3

<400>  233

Ala Ser Gly Gly Tyr Gly Ser Ser Tyr Glu Arg Asp Phe Asp Tyr 
1               5                   10                  15  


<210>  234
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Light Chain CDR1

<400>  234

Gln Asn Ile Asn Val Trp 
1               5       


<210>  235
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Light Chain CDR2

<400>  235

Lys Ala Ser 
1           


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Light Chain CDR3

<400>  236

Gln Gln Gly His Ser Tyr Pro Leu Thr 
1               5                   


<210>  237
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Heavy Chain

<400>  237

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Asn Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Phe Asn Gly Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Gly Ser Ser Tyr Glu Arg Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  238
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-A15-A Heavy Chain

<400>  238
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttcaggcaa cgcattcagt agttactgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaacttc      180

aacggaaggt tcaagggcaa ggccacactg actgcagaca tatcctccac cacagcctac      240

atgctgctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagcgggggc      300

tacggtagta gctacgagag ggactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  239
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-A15-A Light Chain

<400>  239

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  240
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-A15-A Light Chain

<400>  240
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240

gaagacattg ccacttacta ctgtcaacag ggtcacagtt atcctctcac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  241
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Heavy Chain CDR1

<400>  241

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  242
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Heavy Chain CDR2

<400>  242

Ile Tyr Pro Tyr Asn Gly Val Ser 
1               5               


<210>  243
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Heavy Chain CDR3

<400>  243

Ala Arg Ala Tyr Gly Ser Ser Tyr Asp Tyr Tyr Tyr Gly Leu Asp Tyr 
1               5                   10                  15      


<210>  244
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Light Chain CDR1

<400>  244

Gln Ser Val Asp Tyr Asp Gly Ala Gly Tyr 
1               5                   10  


<210>  245
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Light Chain CDR2

<400>  245

Ser Ala Ser 
1           


<210>  246
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Light Chain CDR3

<400>  246

Gln Gln Ser Asn Asp Asp Pro Tyr Thr 
1               5                   


<210>  247
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Heavy Chain

<400>  247

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Asn Ile Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Val Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Ala Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Gly Ser Ser Tyr Asp Tyr Tyr Tyr Gly Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  248
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-C3-A Heavy Chain

<400>  248
gaggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cctctggtta ctcattcact ggctactaca tgcactgggt gaagcagagc      120

catggaaata tcctcgattg gattggatat atttatcctt acaatggtgt ttctagctac      180

aaccagaaat tcaagggcaa ggccacattg actgtagaca agtcctctag cacagcctac      240

atggagctcc gcagcctgac atctgaggcc tctgcagtct attactgtgc aagagcctac      300

ggcagtagct acgattatta ctatggtttg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  249
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C3-A Light Chain

<400>  249

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Ala Gly Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Ser Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Asp Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  250
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-C3-A Light Chain

<400>  250
gacattgtac tgacccaatc tccagcttct ttggctgtgt ctctggggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg ctggttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctctt ctgcatccaa tctacaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga cgatccgtac      300

acgttcggcg gggggaccaa gctggaaata aaa                                   333


<210>  251
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Heavy Chain CDR1

<400>  251

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  252
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Heavy Chain CDR2

<400>  252

Ile Tyr Pro Gly Asn Val Asp Thr 
1               5               


<210>  253
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Heavy Chain CDR3

<400>  253

Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  254
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Light Chain CDR1

<400>  254

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  255
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Light Chain CDR2

<400>  255

Trp Ala Ser 
1           


<210>  256
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Light Chain CDR3

<400>  256

Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  257
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Heavy Chain

<400>  257

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Val His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Val Asp Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  258
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-K13-A Heavy Chain

<400>  258
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacactg tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag gaaatgttga tacttcctac      180

aatcagaatt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagatggt      300

tactatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  259
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K13-A Light Chain

<400>  259

Asp Ile Val Leu Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  260
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-K13-A Light Chain

<400>  260
gacattgtgt tgtcacagtc tccatcctcc ctacctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210>  261
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Heavy Chain CDR1

<400>  261

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  262
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Heavy Chain CDR2

<400>  262

Ile Tyr Pro Gly Asn Val Asp Thr 
1               5               


<210>  263
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Heavy Chain CDR3

<400>  263

Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  264
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Light Chain CDR1

<400>  264

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  265
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Light Chain CDR2

<400>  265

Trp Ala Ser 
1           


<210>  266
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Light Chain CDR3

<400>  266

Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  267
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Heavy Chain

<400>  267

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Val His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Gly Asn Val Asp Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  268
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-L4-A Heavy Chain

<400>  268
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacactg tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggaggt atttatccag gaaatgttga tacttcctac      180

aatcagaatt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagatggt      300

tactatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  269
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-L4-A Light Chain

<400>  269

Asp Ile Val Leu Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  270
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-L4-A Light Chain

<400>  270
gacattgtgt tgtcacagtc tccatcctcc ctacctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttgggc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt tactctcacc      240

atcagtagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210>  271
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Heavy Chain CDR1

<400>  271

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  272
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Heavy Chain CDR2

<400>  272

Ile Asp Leu Glu Thr Gly Gly Thr 
1               5               


<210>  273
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Heavy Chain CDR3

<400>  273

Thr Arg Glu Phe Pro His Tyr Tyr Gly Ser Arg Tyr Gly Phe Pro Tyr 
1               5                   10                  15      


<210>  274
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Light Chain CDR1

<400>  274

Ser Ser Val Ser Tyr 
1               5   


<210>  275
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Light Chain CDR2

<400>  275

Ser Thr Ser 
1           


<210>  276
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Light Chain CDR3

<400>  276

Gln Gln Arg Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  277
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Heavy Chain

<400>  277

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Met Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Leu Glu Thr Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Phe Pro His Tyr Tyr Gly Ser Arg Tyr Gly Phe Pro Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  278
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5-H22-A Heavy Chain

<400>  278
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta cacatttact gactatgaaa tgcactggat gaaacagaca      120

cctgtgcatg gcctggaatg gattggagct attgatcttg aaactggtgg tactgtctac      180

aatcagaagt tcaagggcaa ggccatactg actgcagaca aatcctccaa cacagcctac      240

atggcgctcc gcagtctgac atctgaggac tctgccgtct attactgtac aagagagttc      300

ccccattact acggtagtag gtacggtttt ccttactggg gccaggggac tctggtcact      360

gtctctgca                                                              369


<210>  279
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5-H22-A Light Chain

<400>  279

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Leu Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  280
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5-H22-A Light Chain

<400>  280
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgta gtgccagctc aagtgtaagt tacatgcact ggttacagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc cgtacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  281
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Heavy Chain CDR1

<400>  281

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  282
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Heavy Chain CDR2

<400>  282

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  283
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Heavy Chain CDR3

<400>  283

Ala Arg Leu Gly Trp Phe Leu Pro Leu Gly Ser 
1               5                   10      


<210>  284
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Light Chain CDR1

<400>  284

Ser Ser Val Ser Tyr 
1               5   


<210>  285
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Light Chain CDR2

<400>  285

Ser Thr Ser 
1           


<210>  286
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Light Chain CDR3

<400>  286

His Gln Trp Ser Gly Tyr Met Tyr Thr 
1               5                   


<210>  287
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Heavy Chain

<400>  287

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Trp Phe Leu Pro Leu Gly Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  288
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-O12-A Heavy Chain

<400>  288
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaaat attaatccta gcaatggtgg tactaactac      180

aatgagaagt tcaggagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagactggga      300

tggtttctac cccttgggtc ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  289
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-O12-A Light Chain

<400>  289

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Val Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Gly Tyr Met Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  290
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-O12-A Light Chain

<400>  290
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga ggtgatcacc       60

ctaacctgca gtgccagctc gagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acttctccca aactcttgat ttatagcaca tccaacctgg cttctggagt cccttctcgc      180

ttcagtggca gtgggtctgg gaccttttat tctctcacaa tcagcagtgt ggaggctgaa      240

gatgctgccg attattactg ccatcagtgg agtggttata tgtacacatt cggagggggg      300

accaaactgg aaataaaa                                                    318


<210>  291
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Heavy Chain CDR1

<400>  291

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  292
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Heavy Chain CDR2

<400>  292

Ile His Pro Ser Asp Ser Asp Thr 
1               5               


<210>  293
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Heavy Chain CDR3

<400>  293

Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  294
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Light Chain CDR1

<400>  294

Gln Asn Val Arg Thr Ala 
1               5       


<210>  295
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Light Chain CDR2

<400>  295

Leu Ala Ser 
1           


<210>  296
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Light Chain CDR3

<400>  296

Leu Gln His Trp Asn Tyr Pro Phe Thr 
1               5                   


<210>  297
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Heavy Chain

<400>  297

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Tyr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  298
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-N24-A Heavy Chain

<400>  298
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaaggtg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggccaag gccttgagtg gattggaagg attcatcctt ctgatagtga tactaactac      180

tatcaaaagt tcaagggcaa ggccacattg tctgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aattcccctt      300

tattcctacg ataatagcgg aggttactat cctatggact actggggtca aggaacctca      360

gtcaccgtct cctca                                                       375


<210>  299
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-N24-A Light Chain

<400>  299

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Lys Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  300
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-N24-A Light Chain

<400>  300
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtccgt actgctgtag cctggtatca acagaaacca      120

gggcagtctc ctaaaaaact gatttacttg gcatccaacc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctcg ccattagcaa tgtgcaatct      240

gaagacctgg cagattattt ctgtctgcaa cattggaatt atccattcac gttcggctcg      300

gggacaaggt tggaaataaa a                                                321


<210>  301
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Heavy Chain CDR1

<400>  301

Gly Tyr Thr Phe Thr Thr Tyr Pro 
1               5               


<210>  302
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Heavy Chain CDR2

<400>  302

Phe His Pro Tyr Asn Asp Asp Ser 
1               5               


<210>  303
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Heavy Chain CDR3

<400>  303

Ala Arg Gly Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  304
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Light Chain CDR1

<400>  304

Gly Asp Ile His Asn Tyr 
1               5       


<210>  305
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Light Chain CDR2

<400>  305

Asn Ala Lys 
1           


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Light Chain CDR3

<400>  306

Gln His Phe Trp Ser Ile Pro Tyr Thr 
1               5                   


<210>  307
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Heavy Chain

<400>  307

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Lys Gln Ile His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Val Glu Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Ser Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  308
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-J11-A Heavy Chain

<400>  308
caggttcagc tgcagcagtc tggggctgaa ctagtgaagc ctggagcctc agtgaagatg       60

tcctgcatgg cttctggcta caccttcact acctatccta tagagtggat gaagcagatt      120

catggaaaga gcctagagtg gattggaaat tttcatcctt acaatgatga ttctaagtac      180

aatgaaaagt tcaagggcaa ggccacattg agtgtagaaa aatcctctag cacagtctac      240

ttggagctca gccgatcaac atctgatgac tctgctgttt attactgtgc aagggggtct      300

tatggcccct actggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  309
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-J11-A Light Chain

<400>  309

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Ala Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  310
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-J11-A Light Chain

<400>  310
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtgg ggatattcac aattatttag tatggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaagcct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      240

gatgattttg ggagttatta ctgtcaacat ttttggagta ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  311
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Heavy Chain CDR1

<400>  311

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  312
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Heavy Chain CDR2

<400>  312

Ile Trp Thr Gly Gly Gly Thr 
1               5           


<210>  313
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Heavy Chain CDR3

<400>  313

Ala Arg Gly Pro Pro Leu Ile Tyr Tyr Gly Asp Leu Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  314
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Light Chain CDR1

<400>  314

Gln Asp Ile Asn Lys Tyr 
1               5       


<210>  315
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Light Chain CDR2

<400>  315

Tyr Thr Ser 
1           


<210>  316
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Light Chain CDR3

<400>  316

Leu Gln Tyr Asp Asn Leu Trp Thr 
1               5               


<210>  317
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Heavy Chain

<400>  317

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Leu Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Ile Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Pro Leu Ile Tyr Tyr Gly Asp Leu Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  318
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-L13-A Heavy Chain

<400>  318
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agctatgcta taagctgggt tcgccagcca      120

ccagggaagg gtctggagtg gcttggacta atatggactg gtggaggcac aaattataat      180

tcagctctca aatccagact gagcatcagc aaagacaact ccaagagtca aattttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agggcctcct      300

ctcatctatt atggtgactt gtactacttt gactactggg gccaaggcac cactctcaca      360

gtctcctca                                                              369


<210>  319
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-L13-A Light Chain

<400>  319

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  320
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-L13-A Light Chain

<400>  320
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc       60

atcacttgca aggcaagcca agacattaac aagtatatag cttggtacca acacaagcct      120

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      240

gaagatattg caacttatta ttgtctacag tatgataatc tgtggacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  321
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Heavy Chain CDR1

<400>  321

Gly Phe Ser Phe Ser Asn Phe Gly 
1               5               


<210>  322
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Heavy Chain CDR2

<400>  322

Ile Ser Ser Gly Gly Asp Tyr Ile 
1               5               


<210>  323
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Heavy Chain CDR3

<400>  323

Thr Arg Gly Tyr Phe Asp Tyr 
1               5           


<210>  324
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Light Chain CDR1

<400>  324

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  325
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Light Chain CDR2

<400>  325

Thr Val Ser 
1           


<210>  326
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Light Chain CDR3

<400>  326

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  327
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Heavy Chain

<400>  327

Asp Val Lys Leu Val Glu Ser Gly Glu Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  328
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-P9-A Heavy Chain

<400>  328
gacgtgaagc tggtggagtc tggggaaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctccggatt cagtttcagt aactttggca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatac attagtagtg gtggtgatta catctactat      180

gcagacactg tgaagggccg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatat attactgtac aaggggatac      300

tttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  329
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-P9-A Light Chain

<400>  329

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Arg 
            100                 105                 110         


<210>  330
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-P9-A Light Chain

<400>  330
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acacagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcgggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tacacgttcg gaggggggac caagctggaa atgaga                                336


<210>  331
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Heavy Chain CDR1

<400>  331

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  332
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Heavy Chain CDR2

<400>  332

Ile His Pro Ser Asp Ser Asp Thr 
1               5               


<210>  333
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Heavy Chain CDR3

<400>  333

Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  334
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Light Chain CDR1

<400>  334

Gln Asn Val Arg Thr Ala 
1               5       


<210>  335
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Light Chain CDR2

<400>  335

Leu Ala Ser 
1           


<210>  336
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Light Chain CDR3

<400>  336

Leu Gln His Trp Asn Tyr Pro Phe Thr 
1               5                   


<210>  337
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Heavy Chain

<400>  337

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Tyr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  338
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-B11-A Heavy Chain

<400>  338
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaaggtg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggccaag gccttgagtg gattggaagg attcatcctt ctgatagtga tactaactac      180

tatcaaaagt tcaagggcaa ggccacattg tctgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aattcccctt      300

tattcctacg ataatagcgg aggttactat cctatggact actggggtca aggaacctca      360

gtcaccgtct cctca                                                       375


<210>  339
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-B11-A Light Chain

<400>  339

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Lys Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  340
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-B11-A Light Chain

<400>  340
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtccgt actgctgtag cctggtatca acagaaacca      120

gggcagtctc ctaaaaaact gatttacttg gcatccaacc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctcg ccattagcaa tgtgcaatct      240

gaagacctgg cagattattt ctgtctgcaa cattggaatt atccattcac gttcggctcg      300

gggacaaggt tggaaataaa a                                                321


<210>  341
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Heavy Chain CDR1

<400>  341

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  342
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Heavy Chain CDR2

<400>  342

Ile Asn Ser Asn Asn Gly Gly Thr 
1               5               


<210>  343
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Heavy Chain CDR3

<400>  343

Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr 
1               5                   10              


<210>  344
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Light Chain CDR1

<400>  344

Glu Ser Val Asp Asn Ser Gly Ile Ser Phe 
1               5                   10  


<210>  345
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Light Chain CDR2

<400>  345

Ala Ala Ser 
1           


<210>  346
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Light Chain CDR3

<400>  346

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  347
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Heavy Chain

<400>  347

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Ser Asn Asn Gly Gly Thr Thr Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  348
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-L24-A Heavy Chain

<400>  348
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcctc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaattcta acaatggtgg tactacctac      180

gaccagaagt tcaagggcaa ggccactttg actgtagaca ggtcctccag tacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aaggagaggg      300

gatggtcact ttggggggtt tacttattgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  349
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-L24-A Light Chain

<400>  349

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  350
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-L24-A Light Chain

<400>  350
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  351
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Heavy Chain CDR1

<400>  351

Gly Phe Ser Leu Thr Asn Tyr Ala 
1               5               


<210>  352
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Heavy Chain CDR2

<400>  352

Ile Trp Ser Asp Gly Arg Thr 
1               5           


<210>  353
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Heavy Chain CDR3

<400>  353

Val Arg Ile Glu Gly Gly Ser Tyr Val Gly Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  354
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Light Chain CDR1

<400>  354

Gln Asp Ile Asn Lys Phe 
1               5       


<210>  355
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Light Chain CDR2

<400>  355

Tyr Thr Ser 
1           


<210>  356
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Light Chain CDR3

<400>  356

Leu Gln Tyr Asp Asn Leu Leu Thr 
1               5               


<210>  357
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Heavy Chain

<400>  357

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Asp Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Ile Glu Gly Gly Ser Tyr Val Gly Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  358
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-O3-A Heavy Chain

<400>  358
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaacc aactatgctg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtg atatggagtg atggaaggac agactataat      180

gcagctttca tatctagact gagcatcagc aaggacaact ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatact actgtgtcag aatcgagggt      300

ggtagctacg ttggctggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  359
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-O3-A Light Chain

<400>  359

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  360
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-O3-A Light Chain

<400>  360
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg cacagtcacc       60

atcacttgca aggcaagcca agacattaac aagtttatag cttggtacca acacaagcct      120

ggaaaaggtc ctaggctgct cattcattac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      240

gaagatattg caacttatta ttgtctacag tatgataatc tgctcacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  361
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Heavy Chain CDR1

<400>  361

Gly Tyr Ser Phe Thr Gly Tyr Phe 
1               5               


<210>  362
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Heavy Chain CDR2

<400>  362

Ile Asn Pro Asn Asn Gly Glu Thr 
1               5               


<210>  363
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Heavy Chain CDR3

<400>  363

Ala Arg Gly Gly Thr Gly Thr Gly 
1               5               


<210>  364
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Light Chain CDR1

<400>  364

Gln Gly Ile Ser Ser Asn 
1               5       


<210>  365
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Light Chain CDR2

<400>  365

Tyr Gly Thr 
1           


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Light Chain CDR3

<400>  366

Ile Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  367
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Heavy Chain

<400>  367

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asp Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Gly Thr Gly Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  368
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-M3-A Heavy Chain

<400>  368
gaggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggattc agtgaagata       60

tcctgcaagg cttctggtta ctcatttact ggctacttta tgaactgggt gatgcagagc      120

catggaaaga gccttgagtg gattggacgt attaatccta acaatggtga aactttctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca aatcctctga cacagcccac      240

atggagctcc ggagcctgac atctgaggac tctgcagtct attattgtgc aagagggggg      300

actgggacgg ggtggggcca aggcaccact ctcacagtct cctca                      345


<210>  369
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-M3-A Light Chain

<400>  369

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr Tyr Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Ile Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  370
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-M3-A Light Chain

<400>  370
gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcagc       60

atcacttgcc atgcaagtca gggcattagc agtaatatag ggtggttgca gcagaaacca      120

gggaaatcat ttaagggcct gatctattat ggaaccaact tggaagatgg agttccatca      180

aggttcagtg gcagtggatc tggagcagat tattctctca ccatcagcag cctggaatct      240

gaagatcttg cagactatta ctgtatacag tatgctcagt ttccgtacac gttcggaggg      300

gggaccaaac tggaaataaa a                                                321


<210>  371
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Heavy Chain CDR1

<400>  371

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  372
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Heavy Chain CDR2

<400>  372

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  373
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Heavy Chain CDR3

<400>  373

Ala Arg Glu Thr Gly Asn Tyr 
1               5           


<210>  374
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Light Chain CDR1

<400>  374

Gln Gly Ile Ser Ser Asn 
1               5       


<210>  375
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Light Chain CDR2

<400>  375

His Gly Thr 
1           


<210>  376
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Light Chain CDR3

<400>  376

Val Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  377
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Heavy Chain

<400>  377

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Gly Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  378
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-N22-A Heavy Chain

<400>  378
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc aattactgga tgtactgggt gaagcagagg      120

cctggacaag gccttgattg gattggaaat attaatccta gcaatggtgg tactaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagagagact      300

gggaactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  379
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-N22-A Light Chain

<400>  379

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Ser Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  380
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-N22-A Light Chain

<400>  380
gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcagc       60

atctcttgcc atgcgagtca gggcattagc agtaatatag ggtggttgca gcagaaacca      120

gggaaatcat ttaagggcct gatctatcat ggaaccaact tggaagatgg agttccatca      180

aggttcagtg gcagtggatc tggagcagat tattctctca ccatcagcag cctggaatct      240

gaagattttg cagactatta ctgtgtacag tatgctcagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  381
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Heavy Chain CDR1

<400>  381

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  382
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Heavy Chain CDR2

<400>  382

Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg 
1               5                   10  


<210>  383
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Heavy Chain CDR3

<400>  383

Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  384
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Light Chain CDR1

<400>  384

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  385
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Light Chain CDR2

<400>  385

Lys Val Ser 
1           


<210>  386
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Light Chain CDR3

<400>  386

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  387
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Heavy Chain

<400>  387

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Glu Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  388
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7-B10-A Heavy Chain

<400>  388
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc       60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtagtaa ttatgcaaga      180

tattatgccg attcagtgaa agacagattc accatttcca gagatgagtc acaaagcatg      240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgaga      300

gatcacgatt actacggtag tagttactgg tttgcttact ggggccaagg gactctggtc      360

actgtctctg ca                                                          372


<210>  389
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-B10-A Light Chain

<400>  389

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Ser Ser Ser Gln Ser Leu Val His Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  390
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7-B10-A Light Chain

<400>  390
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gctctagtca gagccttgta cacaataatg gaaacaccta tttacattgg      120

tacctgcaga agccgggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  391
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Heavy Chain CDR1

<400>  391

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly 
1               5                   10  


<210>  392
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Heavy Chain CDR2

<400>  392

Ile Tyr Trp Asp Asp Asp Lys 
1               5           


<210>  393
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Heavy Chain CDR3

<400>  393

Ala Arg Arg Asp Leu His Asp Tyr Asp Gly Trp Phe Ala Tyr 
1               5                   10                  


<210>  394
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Light Chain CDR1

<400>  394

Gln Asn Val Gly Thr Asn 
1               5       


<210>  395
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Light Chain CDR2

<400>  395

Ser Ala Ser 
1           


<210>  396
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Light Chain CDR3

<400>  396

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  397
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Heavy Chain

<400>  397

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Val Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Thr Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Thr Asp Ser Ser Arg Lys Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Asp Leu His Asp Tyr Asp Gly Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  398
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-H5-A Heavy Chain

<400>  398
caggttactc tgaaagagtc tggccctggg atattgcagt cctcccagac cctcagtctg       60

acttgttctt tgtctgggtt ttcactgagc acttctggta tgggtgtgag ctgggttcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga tgacaagcgc      180

tatacccctt ccctgaagag ccggctcaca atctccacgg attcctccag aaagcaggta      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catactactg tgctcgaaga      300

gatcttcatg attacgacgg ctggtttgct tactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  399
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H5-A Light Chain

<400>  399

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ala Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  400
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-H5-A Light Chain

<400>  400
gacattgtga tgacccagtc tcaaaaattc atgtccacag cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca aaatgtgggt actaatgtcg cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatccttcc gctacagtgg agtccctgat      180

cgcttctcag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacagct atcctctcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  401
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Heavy Chain CDR1

<400>  401

Gly Tyr Thr Phe Pro Ser Tyr Val 
1               5               


<210>  402
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Heavy Chain CDR2

<400>  402

Ile Tyr Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  403
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Heavy Chain CDR3

<400>  403

Ala Arg Gly Asp Tyr Gly Asp Ser Ala Trp Phe Pro Tyr 
1               5                   10              


<210>  404
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Light Chain CDR1

<400>  404

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  405
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Light Chain CDR2

<400>  405

Leu Ala Ser 
1           


<210>  406
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Light Chain CDR3

<400>  406

Gln Leu Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  407
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Heavy Chain

<400>  407

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Ser Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Asp Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Asp Ser Ala Trp Phe Pro Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  408
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-G20-A Heavy Chain

<400>  408
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattccct agttatgttt tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat atttatcctt acaatgatgg tactaactac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aaggggagac      300

tatggtgact ccgcctggtt tccttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  409
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-G20-A Light Chain

<400>  409

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Lys Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Leu Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  410
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2-G20-A Light Chain

<400>  410
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctaaaatct      180

ggggtccctg ccaggttcag tggcggtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc tcagtaggga gcttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  411
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Heavy Chain CDR1

<400>  411

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  412
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Heavy Chain CDR2

<400>  412

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  413
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Heavy Chain CDR3

<400>  413

Ala Arg Arg Gly Asp Gly His Tyr Gly Gly Phe Thr Tyr 
1               5                   10              


<210>  414
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Light Chain CDR1

<400>  414

Glu Ser Val Asp Asn Ser Gly Ile Ser Phe 
1               5                   10  


<210>  415
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Light Chain CDR2

<400>  415

Ala Ala Ser 
1           


<210>  416
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Light Chain CDR3

<400>  416

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  417
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Heavy Chain

<400>  417

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Lys Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Gly His Tyr Gly Gly Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  418
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-E2-A Heavy Chain

<400>  418
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcttc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactagctac      180

acccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag caaagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagaagaggg      300

gatggtcact acgggggatt tacttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  419
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-E2-A Light Chain

<400>  419

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  420
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-E2-A Light Chain

<400>  420
gacattgtgc tgacccaatc tccagcttct ttggttgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  421
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Heavy Chain CDR1

<400>  421

Gly Tyr Thr Phe Thr Thr Tyr Gly 
1               5               


<210>  422
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Heavy Chain CDR2

<400>  422

Met Ser Thr Tyr Ser Gly Val Pro 
1               5               


<210>  423
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Heavy Chain CDR3

<400>  423

Ala Ser Gly Asp Val Gly Tyr 
1               5           


<210>  424
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Light Chain CDR1

<400>  424

Gln Asn Val Gly Thr Asn 
1               5       


<210>  425
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Light Chain CDR2

<400>  425

Ser Ala Ser 
1           


<210>  426
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Light Chain CDR3

<400>  426

Gln Gln Tyr Asn Ile Tyr Pro Ser Thr 
1               5                   


<210>  427
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Heavy Chain

<400>  427

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Met Ser Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Asp Val Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  428
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-K16-A Heavy Chain

<400>  428
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttaaagtg gatgggctgg atgagcacct actctggagt gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagcggggac      300

gtcggctact ggggccaagg caccactctc acagtctcct ca                         342


<210>  429
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-K16-A Light Chain

<400>  429

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Ser 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  430
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-K16-A Light Chain

<400>  430
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcac tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacatct atccgtccac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  431
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Heavy Chain CDR1

<400>  431

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  432
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Heavy Chain CDR2

<400>  432

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  433
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Heavy Chain CDR3

<400>  433

Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ser Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Phe 
    


<210>  434
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Light Chain CDR1

<400>  434

Glu Asn Ile Tyr Ser His 
1               5       


<210>  435
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Light Chain CDR2

<400>  435

Asn Ala Lys 
1           


<210>  436
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Light Chain CDR3

<400>  436

Gln His His Tyr Gly Ile Pro Pro Glu 
1               5                   


<210>  437
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Heavy Chain

<400>  437

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ser Tyr Tyr Gly Met Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  438
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Heavy Chain

<400>  438
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tacactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgg tactgactac      180

aaccagaagt tccagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atcggaagat tctgcagtct attactgtgc aagagggggg      300

ttttatggca attacgggtc ttactatggt atggacttct ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  439
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Light Chain

<400>  439

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Phe Cys Gln His His Tyr Gly Ile Pro Pro 
                85                  90                  95      


Glu Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  440
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-C19-A-WT Light Chain

<400>  440
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttat agtcatttag catggtatca gcagacacag      120

ggaaaatctc ctcacctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttattt ctgtcaacat cattatggta ttcctccgga gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  441
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Heavy Chain CDR1

<400>  441

Gly Phe Asn Ile Lys Asn Thr Tyr 
1               5               


<210>  442
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Heavy Chain CDR2

<400>  442

Ile Asn Pro Ala Asn Asp Asp Thr 
1               5               


<210>  443
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Heavy Chain CDR3

<400>  443

Val Tyr Asp Val Arg Trp Tyr Phe Asp Val 
1               5                   10  


<210>  444
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Light Chain CDR1

<400>  444

Gln Gly Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  445
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Light Chain CDR2

<400>  445

Lys Val Ser 
1           


<210>  446
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Light Chain CDR3

<400>  446

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  447
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Heavy Chain

<400>  447

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Pro Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Met His Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Ala Asn Asp Asp Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Tyr Asp Val Arg Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  448
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-L8-A Heavy Chain

<400>  448
gaggttcagc tgcagcagtc tgtggcagag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacac cttctggctt caacattaaa aacacctata tgcactggat gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attaatcctg cgaatgatga tactaaatat      180

gccccgaagt tccaggacaa ggccactata actgcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccatct attactgtgt ctacgacgta      300

cggtggtatt tcgatgtctg gggcacaggg accacggtca ccgtctcctc a               351


<210>  449
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-L8-A Light Chain

<400>  449

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  450
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-L8-A Light Chain

<400>  450
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gggccttgta cacagtaatg ggaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct      300

cctacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  451
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Heavy Chain CDR1

<400>  451

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  452
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Heavy Chain CDR2

<400>  452

Ile Trp Pro Gly Gly Gly Thr 
1               5           


<210>  453
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Heavy Chain CDR3

<400>  453

Ala Arg Thr Gly Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  454
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Light Chain CDR1

<400>  454

Leu Ser Val Asn Tyr 
1               5   


<210>  455
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Light Chain CDR2

<400>  455

Asp Thr Ser 
1           


<210>  456
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Light Chain CDR3

<400>  456

Gln Gln Trp Ser Ser Asn Pro Pro Met Tyr Thr 
1               5                   10      


<210>  457
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Heavy Chain

<400>  457

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  458
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7-D7-A Heavy Chain

<400>  458
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agctatgcta taagctgggt tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagta atatggcctg gtggaggcac aaattataat      180

tcagctctca aatccagact gagcatcagc aaagacaact ccaagagtca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaaatact actgtgccag aactgggtac      300

tactttgact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  459
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-D7-A Light Chain

<400>  459

Gln Leu Ile Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Leu Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile His 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  460
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7-D7-A Light Chain

<400>  460
caacttattc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctt aagtgtaaat tacatgtact ggttccagca gaagccaggc      120

acctccccca aaagatggat tcatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccatgta cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  461
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Heavy Chain CDR1

<400>  461

Gly Phe Thr Phe Ser Asn Tyr Arg 
1               5               


<210>  462
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Heavy Chain CDR2

<400>  462

Ile Thr Asp Lys Ser Asp Asn Tyr Gly Ala 
1               5                   10  


<210>  463
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Heavy Chain CDR3

<400>  463

Ser Arg Asp Gly Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  464
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Light Chain CDR1

<400>  464

Gln Asp Val Gly Ile Val 
1               5       


<210>  465
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Light Chain CDR2

<400>  465

Trp Ala Ser 
1           


<210>  466
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Light Chain CDR3

<400>  466

Gln Gln Tyr Ser Ser Tyr Pro Thr 
1               5               


<210>  467
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Heavy Chain

<400>  467

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Arg Pro Gly Asn 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met His Trp Leu Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Thr Asp Lys Ser Asp Asn Tyr Gly Ala Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Glu Met Lys Arg Leu Arg Glu Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ser Arg Asp Gly Tyr Asp Trp Tyr Phe Asp Leu Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  468
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7-N20-A Heavy Chain

<400>  468
caggtgcagc ttgtagagac cgggggaggc ttggtgaggc ctggaaattc tctgaaactc       60

tcctgtgtta cgtcgggatt cactttcagt aactaccgga tgcactggct tcgccagcct      120

ccagggaaga ggctggagtg gattggtata attacagaca aatctgataa ttatggagca      180

aattatgcag agtctgtgaa aggcagattc gccatttcaa gagatgattc aaaaagtagt      240

gtctatctag agatgaagag attaagagag gaagacactg ccacttattt ttgtagtaga      300

gatggttacg actggtactt cgatctctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  469
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7-N20-A Light Chain

<400>  469

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Arg Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  470
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  7-N20-A Light Chain

<400>  470
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcaga       60

atcacctgta aggccagtca ggatgtggga attgttgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atcccacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  471
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Heavy Chain CDR1

<400>  471

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  472
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Heavy Chain CDR2

<400>  472

Val Trp Pro Gly Gly Gly Thr 
1               5           


<210>  473
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Heavy Chain CDR3

<400>  473

Ala Arg Thr Gly Tyr His Phe Asp Tyr 
1               5                   


<210>  474
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Light Chain CDR1

<400>  474

Ser Ser Val Ser Tyr 
1               5   


<210>  475
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Light Chain CDR2

<400>  475

Asp Thr Ser 
1           


<210>  476
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Light Chain CDR3

<400>  476

Gln Gln Trp Ser Ser Asn Pro Pro Met Tyr Thr 
1               5                   10      


<210>  477
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Heavy Chain

<400>  477

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Val Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Gly Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Gly Tyr His Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  478
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-A17-A Heavy Chain

<400>  478
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agctatgcta taagctgggt tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagta gtatggcctg gtggaggcac aaattataat      180

tcagctctca aatccagact gagcatcaac aaagacaact ccaagagtca agttttctta      240

aagatgaaca gtctgcaaac tgatgacaca ggcaggtact actgtgccag aactgggtac      300

cattttgact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  479
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-A17-A Light Chain

<400>  479

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  480
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-A17-A Light Chain

<400>  480
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgtcagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgt      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccatgta cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  481
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Heavy Chain CDR1

<400>  481

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  482
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Heavy Chain CDR2

<400>  482

Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr 
1               5                   10  


<210>  483
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Heavy Chain CDR3

<400>  483

Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Thr Tyr 
1               5                   10                  15  


<210>  484
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Light Chain CDR1

<400>  484

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  485
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Light Chain CDR2

<400>  485

Lys Val Ser 
1           


<210>  486
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Light Chain CDR3

<400>  486

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  487
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Heavy Chain

<400>  487

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  488
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-H3-A Heavy Chain

<400>  488
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc       60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtagtaa ttatgcaaca      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cctgaaaact gaggacacgg ccatgtatta ctgtgtgaga      300

gatcacgatt actacggtag tagctactgg tttacttact ggggccaagg gactctggtc      360

actgtctctg ca                                                          372


<210>  489
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-H3-A Light Chain

<400>  489

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asp 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  490
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-H3-A Light Chain

<400>  490
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacgataatg gaaacaccta tttacattgg      120

ttcctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg agactgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  491
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Heavy Chain CDR1

<400>  491

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  492
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Heavy Chain CDR2

<400>  492

Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg 
1               5                   10  


<210>  493
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Heavy Chain CDR3

<400>  493

Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  494
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Light Chain CDR1

<400>  494

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  495
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Light Chain CDR2

<400>  495

Lys Val Ser 
1           


<210>  496
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Light Chain CDR3

<400>  496

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  497
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Heavy Chain

<400>  497

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  498
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-L17-A Heavy Chain

<400>  498
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc       60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtagtaa ttatgcaaga      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgaga      300

gatcacgatt actacggtag tagttactgg tttgcttact ggggccaagg gactctggtc      360

actgtctctg ca                                                          372


<210>  499
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8-L17-A Light Chain

<400>  499

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  500
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8-L17-A Light Chain

<400>  500
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacaataatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  501
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Heavy Chain CDR1

<400>  501

Gly Tyr Thr Phe Thr Ser Tyr Ile 
1               5               


<210>  502
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Heavy Chain CDR2

<400>  502

Ile Leu Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  503
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Heavy Chain CDR3

<400>  503

Ala Arg Trp Gly Tyr Ser Asn Phe Leu Asp Ser 
1               5                   10      


<210>  504
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Light Chain CDR1

<400>  504

Gln Asp Ile Asn Asn Tyr 
1               5       


<210>  505
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Light Chain CDR2

<400>  505

Tyr Thr Ser 
1           


<210>  506
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Light Chain CDR3

<400>  506

Gln Gln Gly Asn Thr Leu Pro Pro Thr 
1               5                   


<210>  507
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Heavy Chain

<400>  507

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ser Asn Phe Leu Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  508
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-F6-A Heavy Chain

<400>  508
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact agctatatta tgcactgggt gaagcagaag      120

cctggacagg gccttgagtg gattggatat attcttcctt acaatgatgg tactaagtac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctat      240

atggagctca gaagcctgac ctctgaggac tctgcggtct attactgtgc aagatggggc      300

tatagtaact ttcttgactc ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  509
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9-F6-A Light Chain

<400>  509

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  510
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  9-F6-A Light Chain

<400>  510
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattaac aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattaggaa cctggagcaa      240

gaagacattg ccacttactt ttgccaacag ggtaatacgc ttcctccgac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  511
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Heavy Chain CDR1

<400>  511

Gly Tyr Thr Phe Thr Asp Ser Tyr 
1               5               


<210>  512
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Heavy Chain CDR2

<400>  512

Ile Phe Pro Gly Asn Asp Asn Thr 
1               5               


<210>  513
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Heavy Chain CDR3

<400>  513

Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr 
1               5                   10          


<210>  514
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Light Chain CDR1

<400>  514

Glu Ser Val Asp Ser Tyr Gly His Ser Phe 
1               5                   10  


<210>  515
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Light Chain CDR2

<400>  515

Leu Ala Ser 
1           


<210>  516
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Light Chain CDR3

<400>  516

Gln Gln Asn Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  517
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Heavy Chain

<400>  517

Arg Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Thr Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  518
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-I12-A Heavy Chain

<400>  518
cgggtccagc tacagcagtc tggacctgag ctggtgaggc ctgggacttc agtgaagata       60

tcctgcaagg cttctggcta caccttcact gactcctata taaactgggt gacgcagagg      120

cctggacagg gacttgattg gattggatgg atttttcctg gaaatgataa tacttactac      180

aatgagaagt tcgagggcaa ggccacactt actcttgaca aatcttccag tacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagatcaggg      300

ggattacgac tggggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  519
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10-I12-A Light Chain

<400>  519

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Arg Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly His Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Ile Leu Ile Tyr Leu Ala Ser Lys Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  520
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10-I12-A Light Chain

<400>  520
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctcgagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggcc atagttttat tcactggtac      120

cagcagaaac caggacagcc acccaaaatc ctcatctatc ttgcatccaa gttagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  521
<211>  1262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Spike Protein-T4 Fibritin-HRV3C-His8

<400>  521

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly 
        675                 680                 685             


Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
785                 790                 795                 800 


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
                805                 810                 815     


Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
            820                 825                 830         


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
        835                 840                 845             


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
    850                 855                 860                 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
865                 870                 875                 880 


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
                885                 890                 895     


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
            900                 905                 910         


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
        915                 920                 925             


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
    930                 935                 940                 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
945                 950                 955                 960 


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
                965                 970                 975     


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro 
            980                 985                 990         


Pro Glu Ala Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
        995                 1000                 1005             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1010                 1015                 1020             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1025                 1030                 1035             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1040                 1045                 1050             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1055                 1060                 1065             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1070                 1075                 1080             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1085                 1090                 1095             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1100                 1105                 1110             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1115                 1120                 1125             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1130                 1135                 1140             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1145                 1150                 1155             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1160                 1165                 1170             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1175                 1180                 1185             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1190                 1195                 1200             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1205                 1210                 1215             


Pro Gly  Tyr Ile Pro Glu Ala  Pro Arg Asp Gly Gln  Ala Tyr Val 
    1220                 1225                 1230             


Arg Lys  Asp Gly Glu Trp Val  Leu Leu Ser Thr Phe  Leu Leu Glu 
    1235                 1240                 1245             


Val Leu  Phe Gln Gly Pro His  His His His His His  His His 
    1250                 1255                 1260         


<210>  522
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Beta Variant Spike Protein- T4 Fibritin-HRV3C-His8

<400>  522

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu His Ile Ser Tyr Leu Thr Pro Gly Asp 
                245                 250                 255     


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
            260                 265                 270         


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
        275                 280                 285             


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
    290                 295                 300                 


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
305                 310                 315                 320 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
                325                 330                 335     


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
            340                 345                 350         


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
        355                 360                 365             


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
    370                 375                 380                 


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
385                 390                 395                 400 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
                405                 410                 415     


Gln Thr Gly Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
            420                 425                 430         


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
        435                 440                 445             


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
    450                 455                 460                 


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
465                 470                 475                 480 


Thr Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
                485                 490                 495     


Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg 
            500                 505                 510         


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
        515                 520                 525             


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    530                 535                 540                 


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
545                 550                 555                 560 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
                565                 570                 575     


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
            580                 585                 590         


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
        595                 600                 605             


Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro 
    610                 615                 620                 


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
625                 630                 635                 640 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
                645                 650                 655     


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
            660                 665                 670         


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
        675                 680                 685             


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Val 
    690                 695                 700                 


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
705                 710                 715                 720 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
                725                 730                 735     


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
            740                 745                 750         


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
        755                 760                 765             


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
    770                 775                 780                 


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
785                 790                 795                 800 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
                805                 810                 815     


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
            820                 825                 830         


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
        835                 840                 845             


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
    850                 855                 860                 


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
865                 870                 875                 880 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
                885                 890                 895     


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
            900                 905                 910         


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
        915                 920                 925             


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
    930                 935                 940                 


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
945                 950                 955                 960 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
                965                 970                 975     


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
            980                 985                 990         


Glu Val Gln Ile Asp Arg Leu Ile  Thr Gly Arg Leu Gln  Ser Leu Gln 
        995                 1000                 1005             


Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
    1010                 1015                 1020             


Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1025                 1030                 1035             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1040                 1045                 1050             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1055                 1060                 1065             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1070                 1075                 1080             


Ile Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1085                 1090                 1095             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1100                 1105                 1110             


Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn 
    1115                 1120                 1125             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1130                 1135                 1140             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1145                 1150                 1155             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1160                 1165                 1170             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1175                 1180                 1185             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1190                 1195                 1200             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Gly Tyr 
    1205                 1210                 1215             


Ile Pro  Glu Ala Pro Arg Asp  Gly Gln Ala Tyr Val  Arg Lys Asp 
    1220                 1225                 1230             


Gly Glu  Trp Val Leu Leu Ser  Thr Phe Leu Leu Glu  Val Leu Phe 
    1235                 1240                 1245             


Gln Gly  Pro His His His His  His His His His 
    1250                 1255                 


