                         SEQUENCE LISTING

<110>  CURIA IP HOLDINGS, LLC
 
<120>  SARS-COV-2 SPIKE PROTEIN ANTIBODIES

<130>  147471.002091

<160>  425   

<170>  PatentIn version 3.5

<210>  1
<211>  1262
<212>  PRT
<213>  Artificial

<220>
<223>  SARS-CoV-2 Spike Protein (R691G, R692S, R694A, K995P, V996P)-T4 
       fibritin-HRV3C-His8 Fusion Polypeptide

<400>  1

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly 
        675                 680                 685             


Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
785                 790                 795                 800 


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
                805                 810                 815     


Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
            820                 825                 830         


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
        835                 840                 845             


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
    850                 855                 860                 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
865                 870                 875                 880 


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
                885                 890                 895     


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
            900                 905                 910         


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
        915                 920                 925             


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
    930                 935                 940                 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
945                 950                 955                 960 


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
                965                 970                 975     


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro 
            980                 985                 990         


Pro Glu Ala Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
        995                 1000                 1005             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1010                 1015                 1020             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1025                 1030                 1035             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1040                 1045                 1050             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1055                 1060                 1065             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1070                 1075                 1080             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1085                 1090                 1095             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1100                 1105                 1110             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1115                 1120                 1125             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1130                 1135                 1140             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1145                 1150                 1155             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1160                 1165                 1170             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1175                 1180                 1185             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1190                 1195                 1200             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1205                 1210                 1215             


Pro Gly  Tyr Ile Pro Glu Ala  Pro Arg Asp Gly Gln  Ala Tyr Val 
    1220                 1225                 1230             


Arg Lys  Asp Gly Glu Trp Val  Leu Leu Ser Thr Phe  Leu Leu Glu 
    1235                 1240                 1245             


Val Leu  Phe Gln Gly Pro His  His His His His His  His His 
    1250                 1255                 1260         


<210>  2
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 1-B11-A

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Gly Ser Thr Tyr Tyr Asn Glu Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  3
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 1-B11-A

<400>  3
caggtccagc tacagcagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggcta caccttcact gaccactata taaattgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttttcctg gaagtggtag tacttactac      180

aatgagcagt tcaagggcaa ggccacgctt actgtagaca aatcctccaa cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagatcaggg      300

ggattacgac tggggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  4
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 1-B11-A

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ser Thr Tyr Phe Cys Gln Gln Val Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 1-B11-A

<400>  5
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattt ccacttactt ttgccaacag gttaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 1-B11-A

<400>  6

Gly Tyr Thr Phe Thr Asp His Tyr 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 1-B11-A

<400>  7

Ile Phe Pro Gly Ser Gly Ser Thr 
1               5               


<210>  8
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 1-B11-A

<400>  8

Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr 
1               5                   10          


<210>  9
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 1-B11-A

<400>  9

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  10
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 1-B11-A

<400>  10

Tyr Thr Ser 
1           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 1-B11-A

<400>  11

Gln Gln Val Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  12
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 1-L10-A

<400>  12

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Met Arg Leu Lys Ser Asp Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Ile Glu Gly Tyr Trp Thr Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  13
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 1-L10-A

<400>  13
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcctgtgttg cctctggatt cactttcaat aactactgga tgaactgggt ccgccagtct      120

ccagagaagg ggcttgagtg ggttgctcaa atgagattga aatctgataa ttatgcaaca      180

cattatgcgg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagt      240

gtctatctgc aaatgaacaa cttaagggct gaagacactg gaatttatta ctgtattgaa      300

ggttactgga cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  14
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 1-L10-A

<400>  14

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Asn Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  15
<211>  327
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 1-L10-A

<400>  15
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga acgggtcacc       60

atgacctgca ctgccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

ccaggatcct cccccaaact ctggatttat agcacatcca acctggcttc tggagtccca      180

gctcgcttca gtggcaatgg gtctgggacc tcttactctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgcctc cagtatcatc gctccccacc gtacacgttc      300

ggagggggga ccaagctgga aataaaa                                          327


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 1-L10-A

<400>  16

Gly Phe Thr Phe Asn Asn Tyr Trp 
1               5               


<210>  17
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 1-L10-A

<400>  17

Met Arg Leu Lys Ser Asp Asn Tyr Ala Thr 
1               5                   10  


<210>  18
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 1-L10-A

<400>  18

Ile Glu Gly Tyr Trp Thr Tyr 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 1-L10-A

<400>  19

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  20
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 1-L10-A

<400>  20

Ser Thr Ser 
1           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 1-L10-A

<400>  21

Leu Gln Tyr His Arg Ser Pro Pro Tyr Thr 
1               5                   10  


<210>  22
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-H7-A

<400>  22

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Glu Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Asp Val Leu Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-H7-A

<400>  23
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc ggttacacta tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag aaaatggtga tacttcctac      180

aatcagaagt tcaagggcaa ggccacactg actgtcgaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagatggt      300

tacgacgttc tctatggtat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  24
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-H7-A

<400>  24

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105                 110     


<210>  25
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-H7-A

<400>  25
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtgg      300

acgttcggtg gaggcaccaa gctggatatc aaa                                   333


<210>  26
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 2-H7-A

<400>  26

Gly Tyr Thr Phe Thr Gly Tyr Thr 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 2-H7-A

<400>  27

Ile Tyr Pro Glu Asn Gly Asp Thr 
1               5               


<210>  28
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 2-H7-A

<400>  28

Ala Arg Asp Gly Tyr Asp Val Leu Tyr Gly Met Asp Tyr 
1               5                   10              


<210>  29
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 2-H7-A

<400>  29

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  30
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 2-H7-A

<400>  30

Leu Ala Ser 
1           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 2-H7-A

<400>  31

Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  32
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-J9-A

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  33
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-J9-A

<400>  33
gaggtccagc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tacactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgg tactgactac      180

aaccagaagt tccagggcaa ggccacattg actgtaaaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atcggaagat tctgcagtct attactgtgc aagagggggg      300

ttttatggca attacggggc ttactatggt atggacttct ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  34
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-J9-A

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Thr Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Pro 
                85                  90                  95      


Glu Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-J9-A

<400>  35
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttat agtcatttag catggtatca gcagacacag      120

ggaaaatctc ctcagctcct ggtctataat acaaaaacct tagcagaagg tgtgccatca      180

aggttcactg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat cattatggta ttcctccgga gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  36
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 2-J9-A

<400>  36

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 2-J9-A

<400>  37

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  38
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 2-J9-A

<400>  38

Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Phe 
    


<210>  39
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 2-J9-A

<400>  39

Glu Asn Ile Tyr Ser His 
1               5       


<210>  40
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 2-J9-A

<400>  40

Asn Thr Lys 
1           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 2-J9-A

<400>  41

Gln His His Tyr Gly Ile Pro Pro Glu 
1               5                   


<210>  42
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-O12-A

<400>  42

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Ser Asn Asn Gly Gly Thr Thr Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  43
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-O12-A

<400>  43
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcctc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaattcta acaatggtgg tactacctac      180

gaccagaagt tcaagggcaa ggccactttg actgtagaca ggtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aaggagaggg      300

gatggtcact ttggggggtt tacttattgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  44
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-O12-A

<400>  44

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  45
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-O12-A

<400>  45
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  46
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 2-O12-A

<400>  46

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 2-O12-A

<400>  47

Ile Asn Ser Asn Asn Gly Gly Thr 
1               5               


<210>  48
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 2-O12-A

<400>  48

Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr 
1               5                   10              


<210>  49
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 2-O12-A

<400>  49

Glu Ser Val Asp Asn Ser Gly Ile Ser Phe 
1               5                   10  


<210>  50
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 2-O12-A

<400>  50

Ala Ala Ser 
1           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 2-O12-A

<400>  51

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  52
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-P2-A

<400>  52

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Ile Gly Asn Gly Tyr Thr Glu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  53
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-P2-A

<400>  53
gaggtccagc ttcagcagtc tggagctgag ctggtgaggc ctgggtcctc agtgaagatg       60

tcctgcaaga cttctggata tacattcaca agctacggta taaactgggt gaagcagagg      120

cctggacagg gcctggaatg gattggatat atttatattg gaaatggtta tactgaatac      180

aatgagaagt tcaagggtaa ggccacactg acttcagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcaatct atttctgtgc aagaggaggg      300

gttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  54
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-P2-A

<400>  54

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  55
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-P2-A

<400>  55
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  56
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 2-P2-A

<400>  56

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 2-P2-A

<400>  57

Ile Tyr Ile Gly Asn Gly Tyr Thr 
1               5               


<210>  58
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 2-P2-A

<400>  58

Ala Arg Gly Gly Val Asp Tyr 
1               5           


<210>  59
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 2-P2-A

<400>  59

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  60
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 2-P2-A

<400>  60

Lys Val Ser 
1           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 2-P2-A

<400>  61

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  62
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 3-E13-A

<400>  62

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  63
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 3-E13-A

<400>  63
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tacactgggt gaaacagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgg tactgactac      180

aaccagaagt tccagggcaa ggccacattg actgtaaaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atcggaagat tttgcagtct attactgtgc aagagggggg      300

ttttatggca attacggggc ttactatggt atggacttct ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  64
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 3-E13-A

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Pro 
                85                  90                  95      


Glu Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  65
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 3-E13-A

<400>  65
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttat agtcatttag catggtatca gcagacacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacat ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat cattatggta ttcctccgga gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  66
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 3-E13-A

<400>  66

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 3-E13-A

<400>  67

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  68
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 3-E13-A

<400>  68

Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ala Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Phe 
    


<210>  69
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 3-E13-A

<400>  69

Glu Asn Ile Tyr Ser His 
1               5       


<210>  70
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 3-E13-A

<400>  70

Asn Ala Lys 
1           


<210>  71
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 3-E13-A

<400>  71

Gln His His Tyr Gly Ile Pro Pro Glu 
1               5                   


<210>  72
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 3-P7-A

<400>  72

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asp Tyr Thr Asn Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  73
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 3-P7-A

<400>  73
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacagta tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag gaaatgatga tacttcctac      180

aatcagaagt tcaagggcaa ggccacactg actgtcgaca aatcctccag cacagcctac      240

atgcagctca gcagcctcac atctgaggac tctgcggtct atttctgtac aagagactat      300

actaactacc cttttgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  74
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 3-P7-A

<400>  74

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  75
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 3-P7-A

<400>  75
gacattgtgc tgacacagtc tcctgcttcc ttacctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagagac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tgccagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttcctccg      300

acgttcggtg gaggcaccaa ggtggagatc aaa                                   333


<210>  76
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 3-P7-A

<400>  76

Gly Tyr Thr Phe Thr Ser Tyr Ser 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 3-P7-A

<400>  77

Ile Tyr Pro Gly Asn Asp Asp Thr 
1               5               


<210>  78
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 3-P7-A

<400>  78

Thr Arg Asp Tyr Thr Asn Tyr Pro Phe Asp Tyr 
1               5                   10      


<210>  79
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 3-P7-A

<400>  79

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  80
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 3-P7-A

<400>  80

Leu Ala Ser 
1           


<210>  81
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 3-P7-A

<400>  81

Gln His Ser Arg Glu Leu Pro Pro Thr 
1               5                   


<210>  82
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-A15-A

<400>  82

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Asn Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Phe Asn Gly Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Gly Ser Ser Tyr Glu Arg Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-A15-A

<400>  83
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttcaggcaa cgcattcagt agttactgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaacttc      180

aacggaaggt tcaagggcaa ggccacactg actgcagaca tatcctccac cacagcctac      240

atgctgctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagcgggggc      300

tacggtagta gctacgagag ggactttgac tactggggcc aaggcaccac tctcacagtc      360

tcctca                                                                 366


<210>  84
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-A15-A

<400>  84

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  85
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-A15-A

<400>  85
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240

gaagacattg ccacttacta ctgtcaacag ggtcacagtt atcctctcac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  86
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 4-A15-A

<400>  86

Gly Asn Ala Phe Ser Ser Tyr Trp 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 4-A15-A

<400>  87

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  88
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 4-A15-A

<400>  88

Ala Ser Gly Gly Tyr Gly Ser Ser Tyr Glu Arg Asp Phe Asp Tyr 
1               5                   10                  15  


<210>  89
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 4-A15-A

<400>  89

Gln Asn Ile Asn Val Trp 
1               5       


<210>  90
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 4-A15-A

<400>  90

Lys Ala Ser 
1           


<210>  91
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 4-A15-A

<400>  91

Gln Gln Gly His Ser Tyr Pro Leu Thr 
1               5                   


<210>  92
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-C3-A

<400>  92

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Asn Ile Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Val Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Ala Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Gly Ser Ser Tyr Asp Tyr Tyr Tyr Gly Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  93
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-C3-A

<400>  93
gaggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cctctggtta ctcattcact ggctactaca tgcactgggt gaagcagagc      120

catggaaata tcctcgattg gattggatat atttatcctt acaatggtgt ttctagctac      180

aaccagaaat tcaagggcaa ggccacattg actgtagaca agtcctctag cacagcctac      240

atggagctcc gcagcctgac atctgaggcc tctgcagtct attactgtgc aagagcctac      300

ggcagtagct acgattatta ctatggtttg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  94
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-C3-A

<400>  94

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Ala Gly Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Ser Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Asp Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  95
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-C3-A

<400>  95
gacattgtac tgacccaatc tccagcttct ttggctgtgt ctctggggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg ctggttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctctt ctgcatccaa tctacaatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga cgatccgtac      300

acgttcggcg gggggaccaa gctggaaata aaa                                   333


<210>  96
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 4-C3-A

<400>  96

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 4-C3-A

<400>  97

Ile Tyr Pro Tyr Asn Gly Val Ser 
1               5               


<210>  98
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 4-C3-A

<400>  98

Ala Arg Ala Tyr Gly Ser Ser Tyr Asp Tyr Tyr Tyr Gly Leu Asp Tyr 
1               5                   10                  15      


<210>  99
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 4-C3-A

<400>  99

Gln Ser Val Asp Tyr Asp Gly Ala Gly Tyr 
1               5                   10  


<210>  100
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 4-C3-A

<400>  100

Ser Ala Ser 
1           


<210>  101
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 4-C3-A

<400>  101

Gln Gln Ser Asn Asp Asp Pro Tyr Thr 
1               5                   


<210>  102
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-K13-A

<400>  102

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Val His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Val Asp Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  103
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-K13-A

<400>  103
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacactg tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag gaaatgttga tacttcctac      180

aatcagaatt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagatggt      300

tactatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  104
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-K13-A

<400>  104

Asp Ile Val Leu Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  105
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-K13-A

<400>  105
gacattgtgt tgtcacagtc tccatcctcc ctacctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210>  106
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 4-K13-A

<400>  106

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 4-K13-A

<400>  107

Ile Tyr Pro Gly Asn Val Asp Thr 
1               5               


<210>  108
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 4-K13-A

<400>  108

Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  109
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 4-K13-A

<400>  109

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  110
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 4-K13-A

<400>  110

Trp Ala Ser 
1           


<210>  111
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 4-K13-A

<400>  111

Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  112
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-L4-A

<400>  112

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Val His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Gly Asn Val Asp Thr Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  113
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-L4-A

<400>  113
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacactg tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggaggt atttatccag gaaatgttga tacttcctac      180

aatcagaatt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagatggt      300

tactatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a               351


<210>  114
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-L4-A

<400>  114

Asp Ile Val Leu Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  115
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-L4-A

<400>  115
gacattgtgt tgtcacagtc tccatcctcc ctacctgtgt cagttggaga gaaggttact       60

atgagctgca agtccagtca gagcctttta tatagtagca atcaaaagaa ctacttgggc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt tactctcacc      240

atcagtagtg tgaaggctga agacctggca gtttattact gtcagcaata ttatagctat      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210>  116
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 4-L4-A

<400>  116

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 4-L4-A

<400>  117

Ile Tyr Pro Gly Asn Val Asp Thr 
1               5               


<210>  118
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 4-L4-A

<400>  118

Ala Arg Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  119
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 4-L4-A

<400>  119

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  120
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 4-L4-A

<400>  120

Trp Ala Ser 
1           


<210>  121
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 4-L4-A

<400>  121

Gln Gln Tyr Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  122
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 5-H22-A

<400>  122

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Met Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Leu Glu Thr Gly Gly Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Ala Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Phe Pro His Tyr Tyr Gly Ser Arg Tyr Gly Phe Pro Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  123
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 5-H22-A

<400>  123
caggttcaac tgcagcagtc tggggctgag ctggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta cacatttact gactatgaaa tgcactggat gaaacagaca      120

cctgtgcatg gcctggaatg gattggagct attgatcttg aaactggtgg tactgtctac      180

aatcagaagt tcaagggcaa ggccatactg actgcagaca aatcctccaa cacagcctac      240

atggcgctcc gcagtctgac atctgaggac tctgccgtct attactgtac aagagagttc      300

ccccattact acggtagtag gtacggtttt ccttactggg gccaggggac tctggtcact      360

gtctctgca                                                              369


<210>  124
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 5-H22-A

<400>  124

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Leu Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  125
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 5-H22-A

<400>  125
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgta gtgccagctc aagtgtaagt tacatgcact ggttacagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc cgtacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  126
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 5-H22-A

<400>  126

Gly Tyr Thr Phe Thr Asp Tyr Glu 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 5-H22-A

<400>  127

Ile Asp Leu Glu Thr Gly Gly Thr 
1               5               


<210>  128
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 5-H22-A

<400>  128

Thr Arg Glu Phe Pro His Tyr Tyr Gly Ser Arg Tyr Gly Phe Pro Tyr 
1               5                   10                  15      


<210>  129
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 5-H22-A

<400>  129

Ser Ser Val Ser Tyr 
1               5   


<210>  130
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 5-H22-A

<400>  130

Ser Thr Ser 
1           


<210>  131
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 5-H22-A

<400>  131

Gln Gln Arg Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  132
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 5-P24-A

<400>  132

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  133
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 5-P24-A

<400>  133
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacagta tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag gaaatggtga tacttcctac      180

actcagaagt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagactat      300

agtaactacc cttttgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  134
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 5-P24-A

<400>  134

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  135
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 5-P24-A

<400>  135
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact       60

atgagctgca agtccagtca gagcctttta aatagtagca atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg      180

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattacttct gtcagcaaca ttatagcact      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  136
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 5-P24-A

<400>  136

Gly Tyr Thr Phe Thr Ser Tyr Ser 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 5-P24-A

<400>  137

Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               


<210>  138
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 5-P24-A

<400>  138

Ala Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Tyr 
1               5                   10      


<210>  139
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 5-P24-A

<400>  139

Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  140
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 5-P24-A

<400>  140

Phe Ala Ser 
1           


<210>  141
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 5-P24-A

<400>  141

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  142
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 6-O12-A

<400>  142

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Trp Phe Leu Pro Leu Gly Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  143
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 6-O12-A

<400>  143
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaaat attaatccta gcaatggtgg tactaactac      180

aatgagaagt tcaggagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagactggga      300

tggtttctac cccttgggtc ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  144
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 6-O12-A

<400>  144

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Val Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Gly Tyr Met Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  145
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 6-O12-A

<400>  145
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga ggtgatcacc       60

ctaacctgca gtgccagctc gagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acttctccca aactcttgat ttatagcaca tccaacctgg cttctggagt cccttctcgc      180

ttcagtggca gtgggtctgg gaccttttat tctctcacaa tcagcagtgt ggaggctgaa      240

gatgctgccg attattactg ccatcagtgg agtggttata tgtacacatt cggagggggg      300

accaaactgg aaataaaa                                                    318


<210>  146
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 6-O12-A

<400>  146

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  147
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 6-O12-A

<400>  147

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  148
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 6-O12-A

<400>  148

Ala Arg Leu Gly Trp Phe Leu Pro Leu Gly Ser 
1               5                   10      


<210>  149
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 6-O12-A

<400>  149

Ser Ser Val Ser Tyr 
1               5   


<210>  150
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 6-O12-A

<400>  150

Ser Thr Ser 
1           


<210>  151
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 6-O12-A

<400>  151

His Gln Trp Ser Gly Tyr Met Tyr Thr 
1               5                   


<210>  152
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-N24-A

<400>  152

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Tyr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  153
<211>  375
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-N24-A

<400>  153
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaaggtg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggccaag gccttgagtg gattggaagg attcatcctt ctgatagtga tactaactac      180

tatcaaaagt tcaagggcaa ggccacattg tctgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aattcccctt      300

tattcctacg ataatagcgg aggttactat cctatggact actggggtca aggaacctca      360

gtcaccgtct cctca                                                       375


<210>  154
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-N24-A

<400>  154

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Lys Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  155
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-N24-A

<400>  155
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtccgt actgctgtag cctggtatca acagaaacca      120

gggcagtctc ctaaaaaact gatttacttg gcatccaacc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctcg ccattagcaa tgtgcaatct      240

gaagacctgg cagattattt ctgtctgcaa cattggaatt atccattcac gttcggctcg      300

gggacaaggt tggaaataaa a                                                321


<210>  156
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 8-N24-A

<400>  156

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  157
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 8-N24-A

<400>  157

Ile His Pro Ser Asp Ser Asp Thr 
1               5               


<210>  158
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 8-N24-A

<400>  158

Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  159
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 8-N24-A

<400>  159

Gln Asn Val Arg Thr Ala 
1               5       


<210>  160
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 8-N24-A

<400>  160

Leu Ala Ser 
1           


<210>  161
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 8-N24-A

<400>  161

Leu Gln His Trp Asn Tyr Pro Phe Thr 
1               5                   


<210>  162
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-J11-A

<400>  162

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Pro Ile Glu Trp Met Lys Gln Ile His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe His Pro Tyr Asn Asp Asp Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Val Glu Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Ser Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  163
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-J11-A

<400>  163
caggttcagc tgcagcagtc tggggctgaa ctagtgaagc ctggagcctc agtgaagatg       60

tcctgcatgg cttctggcta caccttcact acctatccta tagagtggat gaagcagatt      120

catggaaaga gcctagagtg gattggaaat tttcatcctt acaatgatga ttctaagtac      180

aatgaaaagt tcaagggcaa ggccacattg agtgtagaaa aatcctctag cacagtctac      240

ttggagctca gccgatcaac atctgatgac tctgctgttt attactgtgc aagggggtct      300

tatggcccct actggtactt cgatgtctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  164
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-J11-A

<400>  164

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Ala Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  165
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-J11-A

<400>  165
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtgg ggatattcac aattatttag tatggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaagcct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      240

gatgattttg ggagttatta ctgtcaacat ttttggagta ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  166
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 9-J11-A

<400>  166

Gly Tyr Thr Phe Thr Thr Tyr Pro 
1               5               


<210>  167
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 9-J11-A

<400>  167

Phe His Pro Tyr Asn Asp Asp Ser 
1               5               


<210>  168
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 9-J11-A

<400>  168

Ala Arg Gly Ser Tyr Gly Pro Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  169
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 9-J11-A

<400>  169

Gly Asp Ile His Asn Tyr 
1               5       


<210>  170
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 9-J11-A

<400>  170

Asn Ala Lys 
1           


<210>  171
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 9-J11-A

<400>  171

Gln His Phe Trp Ser Ile Pro Tyr Thr 
1               5                   


<210>  172
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-K4-A

<400>  172

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Asn Tyr 
            20                  25                  30          


Ser Phe His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Cys Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  173
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-K4-A

<400>  173
caggcttatc tacagcagtc tggggctgaa ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttccc aattacagtt tccactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag gaaatgatga tacttcctac      180

aatcagaggt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtgc aagagactat      300

agtaactacc cttttgactg ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  174
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-K4-A

<400>  174

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  175
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-K4-A

<400>  175
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  176
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 9-K4-A

<400>  176

Gly Tyr Thr Phe Pro Asn Tyr Ser 
1               5               


<210>  177
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 9-K4-A

<400>  177

Ile Tyr Pro Gly Asn Asp Asp Thr 
1               5               


<210>  178
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 9-K4-A

<400>  178

Ala Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Cys 
1               5                   10      


<210>  179
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 9-K4-A

<400>  179

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  180
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 9-K4-A

<400>  180

Leu Ala Ser 
1           


<210>  181
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 9-K4-A

<400>  181

Gln His Ser Arg Glu Leu Pro Pro Thr 
1               5                   


<210>  182
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-L13-A

<400>  182

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Leu Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Ile Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Pro Leu Ile Tyr Tyr Gly Asp Leu Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  183
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-L13-A

<400>  183
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agctatgcta taagctgggt tcgccagcca      120

ccagggaagg gtctggagtg gcttggacta atatggactg gtggaggcac aaattataat      180

tcagctctca aatccagact gagcatcagc aaagacaact ccaagagtca aattttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag agggcctcct      300

ctcatctatt atggtgactt gtactacttt gactactggg gccaaggcac cactctcaca      360

gtctcctca                                                              369


<210>  184
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-L13-A

<400>  184

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  185
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-L13-A

<400>  185
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg caaagtcacc       60

atcacttgca aggcaagcca agacattaac aagtatatag cttggtacca acacaagcct      120

ggaaaaggtc ctaggctgct catacattac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      240

gaagatattg caacttatta ttgtctacag tatgataatc tgtggacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  186
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 9-L13-A

<400>  186

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  187
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 9-L13-A

<400>  187

Ile Trp Thr Gly Gly Gly Thr 
1               5           


<210>  188
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 9-L13-A

<400>  188

Ala Arg Gly Pro Pro Leu Ile Tyr Tyr Gly Asp Leu Tyr Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  189
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 9-L13-A

<400>  189

Gln Asp Ile Asn Lys Tyr 
1               5       


<210>  190
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 9-L13-A

<400>  190

Tyr Thr Ser 
1           


<210>  191
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 9-L13-A

<400>  191

Leu Gln Tyr Asp Asn Leu Trp Thr 
1               5               


<210>  192
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-P9-A

<400>  192

Asp Val Lys Leu Val Glu Ser Gly Glu Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Asp Tyr Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  193
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-P9-A

<400>  193
gacgtgaagc tggtggagtc tggggaaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctccggatt cagtttcagt aactttggca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatac attagtagtg gtggtgatta catctactat      180

gcagacactg tgaagggccg attcaccatc tccagagaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatat attactgtac aaggggatac      300

tttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  194
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-P9-A

<400>  194

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Arg 
            100                 105                 110         


<210>  195
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-P9-A

<400>  195
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acacagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcgggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tacacgttcg gaggggggac caagctggaa atgaga                                336


<210>  196
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 9-P9-A

<400>  196

Gly Phe Ser Phe Ser Asn Phe Gly 
1               5               


<210>  197
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 9-P9-A

<400>  197

Ile Ser Ser Gly Gly Asp Tyr Ile 
1               5               


<210>  198
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 9-P9-A

<400>  198

Thr Arg Gly Tyr Phe Asp Tyr 
1               5           


<210>  199
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 9-P9-A

<400>  199

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  200
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 9-P9-A

<400>  200

Thr Val Ser 
1           


<210>  201
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 9-P9-A

<400>  201

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  202
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-B11-A

<400>  202

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile His Pro Ser Asp Ser Asp Thr Asn Tyr Tyr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125 


<210>  203
<211>  375
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-B11-A

<400>  203
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaaggtg       60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggccaag gccttgagtg gattggaagg attcatcctt ctgatagtga tactaactac      180

tatcaaaagt tcaagggcaa ggccacattg tctgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aattcccctt      300

tattcctacg ataatagcgg aggttactat cctatggact actggggtca aggaacctca      360

gtcaccgtct cctca                                                       375


<210>  204
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-B11-A

<400>  204

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Arg Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Lys Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Asn Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Leu Gln His Trp Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  205
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-B11-A

<400>  205
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcacc       60

atcacctgca aggccagtca gaatgtccgt actgctgtag cctggtatca acagaaacca      120

gggcagtctc ctaaaaaact gatttacttg gcatccaacc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctcg ccattagcaa tgtgcaatct      240

gaagacctgg cagattattt ctgtctgcaa cattggaatt atccattcac gttcggctcg      300

gggacaaggt tggaaataaa a                                                321


<210>  206
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 10-B11-A

<400>  206

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  207
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 10-B11-A

<400>  207

Ile His Pro Ser Asp Ser Asp Thr 
1               5               


<210>  208
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 10-B11-A

<400>  208

Ala Ile Pro Leu Tyr Ser Tyr Asp Asn Ser Gly Gly Tyr Tyr Pro Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  209
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 10-B11-A

<400>  209

Gln Asn Val Arg Thr Ala 
1               5       


<210>  210
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 10-B11-A

<400>  210

Leu Ala Ser 
1           


<210>  211
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 10-B11-A

<400>  211

Leu Gln His Trp Asn Tyr Pro Phe Thr 
1               5                   


<210>  212
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-B13-A

<400>  212

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Gly Arg Gly Phe Ile Ala Thr Val Val Glu Val Phe Asp His Trp Gly 
            100                 105                 110         


Leu Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  213
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-B13-A

<400>  213
caggttcagc tgcagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt aactactgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aacggaaact tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

attcaactca gcagcctgac ctctgaggac tctgcggtct atttctgtgg aaggggattt      300

attgctacgg tagtagaggt ttttgaccac tggggcctag gcaccactct cacagtctcc      360

tca                                                                    363


<210>  214
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-B13-A

<400>  214

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  215
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-B13-A

<400>  215
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctattac acatcaagat tacagtcagg agtcccatca      180

aggttcagtg gcagtgggac tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  216
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 10-B13-A

<400>  216

Gly Tyr Ala Phe Ser Asn Tyr Trp 
1               5               


<210>  217
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 10-B13-A

<400>  217

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  218
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 10-B13-A

<400>  218

Gly Arg Gly Phe Ile Ala Thr Val Val Glu Val Phe Asp His 
1               5                   10                  


<210>  219
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 10-B13-A

<400>  219

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  220
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 10-B13-A

<400>  220

Tyr Thr Ser 
1           


<210>  221
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 10-B13-A

<400>  221

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  222
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-L12-A

<400>  222

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  223
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-L12-A

<400>  223
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacagta tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag gaaatggtga tacttcctac      180

aatcagaagt tcaagggcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaagac tctgcggtct atttctgtac aagagactat      300

agtaactacc cttttgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  224
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-L12-A

<400>  224

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  225
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-L12-A

<400>  225
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttattt gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  226
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 10-L12-A

<400>  226

Gly Tyr Thr Phe Thr Ser Tyr Ser 
1               5               


<210>  227
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 10-L12-A

<400>  227

Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               


<210>  228
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 10-L12-A

<400>  228

Thr Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Tyr 
1               5                   10      


<210>  229
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 10-L12-A

<400>  229

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  230
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 10-L12-A

<400>  230

Leu Ala Ser 
1           


<210>  231
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 10-L12-A

<400>  231

Gln His Ser Arg Glu Leu Pro Pro Thr 
1               5                   


<210>  232
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-L24-A

<400>  232

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Ser Asn Asn Gly Gly Thr Thr Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  233
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-L24-A

<400>  233
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcctc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaattcta acaatggtgg tactacctac      180

gaccagaagt tcaagggcaa ggccactttg actgtagaca ggtcctccag tacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aaggagaggg      300

gatggtcact ttggggggtt tacttattgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  234
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-L24-A

<400>  234

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  235
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-L24-A

<400>  235
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  236
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 10-L24-A

<400>  236

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  237
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 10-L24-A

<400>  237

Ile Asn Ser Asn Asn Gly Gly Thr 
1               5               


<210>  238
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 10-L24-A

<400>  238

Ala Arg Arg Gly Asp Gly His Phe Gly Gly Phe Thr Tyr 
1               5                   10              


<210>  239
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 10-L24-A

<400>  239

Glu Ser Val Asp Asn Ser Gly Ile Ser Phe 
1               5                   10  


<210>  240
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 10-L24-A

<400>  240

Ala Ala Ser 
1           


<210>  241
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 10-L24-A

<400>  241

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  242
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-O24-A

<400>  242

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  243
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-O24-A

<400>  243
caggcttatc tacagcagtc tggggctgag ctggtgaggc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacagta tgcactgggt aaagcagaca      120

cctagacagg gcctggaatg gattggagct atttatccag gaaatgatga tacttcctac      180

aatcagaagt tcaagggcaa ggccacactg actgtagaca gatcctccag cacagcctac      240

atgcagctca gcagcctcac atctgaagac tctgcggtct atttctgtac aagagactat      300

agtaactacc cttttgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  244
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-O24-A

<400>  244

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Phe Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  245
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-O24-A

<400>  245
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ttctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagagac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttcctccg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  246
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 10-O24-A

<400>  246

Gly Tyr Thr Phe Thr Ser Tyr Ser 
1               5               


<210>  247
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 10-O24-A

<400>  247

Ile Tyr Pro Gly Asn Asp Asp Thr 
1               5               


<210>  248
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 10-O24-A

<400>  248

Thr Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Tyr 
1               5                   10      


<210>  249
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 10-O24-A

<400>  249

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  250
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 10-O24-A

<400>  250

Leu Ala Ser 
1           


<210>  251
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 10-O24-A

<400>  251

Gln His Ser Arg Glu Leu Pro Pro Thr 
1               5                   


<210>  252
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-O3-A

<400>  252

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Asp Gly Arg Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Ile Glu Gly Gly Ser Tyr Val Gly Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  253
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-O3-A

<400>  253
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaacc aactatgctg tacactgggt tcgccagtct      120

ccaggaaagg gtctggagtg gctgggagtg atatggagtg atggaaggac agactataat      180

gcagctttca tatctagact gagcatcagc aaggacaact ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatact actgtgtcag aatcgagggt      300

ggtagctacg ttggctggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  254
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-O3-A

<400>  254

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Phe 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  255
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-O3-A

<400>  255
gacatccaga tgacacagtc tccatcctca ctgtctgcat ctctgggagg cacagtcacc       60

atcacttgca aggcaagcca agacattaac aagtttatag cttggtacca acacaagcct      120

ggaaaaggtc ctaggctgct cattcattac acatctacat tacagccagg catcccatca      180

aggttcagtg gaagtgggtc tgggagagat tattccttca gcatcagcaa cctggagcct      240

gaagatattg caacttatta ttgtctacag tatgataatc tgctcacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  256
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 10-O3-A

<400>  256

Gly Phe Ser Leu Thr Asn Tyr Ala 
1               5               


<210>  257
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 10-O3-A

<400>  257

Ile Trp Ser Asp Gly Arg Thr 
1               5           


<210>  258
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 10-O3-A

<400>  258

Val Arg Ile Glu Gly Gly Ser Tyr Val Gly Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  259
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 10-O3-A

<400>  259

Gln Asp Ile Asn Lys Phe 
1               5       


<210>  260
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 10-O3-A

<400>  260

Tyr Thr Ser 
1           


<210>  261
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 10-O3-A

<400>  261

Leu Gln Tyr Asp Asn Leu Leu Thr 
1               5               


<210>  262
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-M3-A

<400>  262

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Asp 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asp Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Gly Thr Gly Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  263
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-M3-A

<400>  263
gaggttcagc tgcagcagtc tggacctgag ctggtgaagc ctggggattc agtgaagata       60

tcctgcaagg cttctggtta ctcatttact ggctacttta tgaactgggt gatgcagagc      120

catggaaaga gccttgagtg gattggacgt attaatccta acaatggtga aactttctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca aatcctctga cacagcccac      240

atggagctcc ggagcctgac atctgaggac tctgcagtct attattgtgc aagagggggg      300

actgggacgg ggtggggcca aggcaccact ctcacagtct cctca                      345


<210>  264
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-M3-A

<400>  264

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr Tyr Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Ile Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  265
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-M3-A

<400>  265
gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcagc       60

atcacttgcc atgcaagtca gggcattagc agtaatatag ggtggttgca gcagaaacca      120

gggaaatcat ttaagggcct gatctattat ggaaccaact tggaagatgg agttccatca      180

aggttcagtg gcagtggatc tggagcagat tattctctca ccatcagcag cctggaatct      240

gaagatcttg cagactatta ctgtatacag tatgctcagt ttccgtacac gttcggaggg      300

gggaccaaac tggaaataaa a                                                321


<210>  266
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 4-M3-A

<400>  266

Gly Tyr Ser Phe Thr Gly Tyr Phe 
1               5               


<210>  267
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 4-M3-A

<400>  267

Ile Asn Pro Asn Asn Gly Glu Thr 
1               5               


<210>  268
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 4-M3-A

<400>  268

Ala Arg Gly Gly Thr Gly Thr Gly 
1               5               


<210>  269
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 4-M3-A

<400>  269

Gln Gly Ile Ser Ser Asn 
1               5       


<210>  270
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 4-M3-A

<400>  270

Tyr Gly Thr 
1           


<210>  271
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 4-M3-A

<400>  271

Ile Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  272
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-N22-A

<400>  272

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Gly Asn Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  273
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-N22-A

<400>  273
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc aattactgga tgtactgggt gaagcagagg      120

cctggacaag gccttgattg gattggaaat attaatccta gcaatggtgg tactaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attattgtgc aagagagact      300

gggaactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  274
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-N22-A

<400>  274

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Ser Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  275
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-N22-A

<400>  275
gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcagc       60

atctcttgcc atgcgagtca gggcattagc agtaatatag ggtggttgca gcagaaacca      120

gggaaatcat ttaagggcct gatctatcat ggaaccaact tggaagatgg agttccatca      180

aggttcagtg gcagtggatc tggagcagat tattctctca ccatcagcag cctggaatct      240

gaagattttg cagactatta ctgtgtacag tatgctcagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  276
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 4-N22-A

<400>  276

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  277
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 4-N22-A

<400>  277

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  278
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 4-N22-A

<400>  278

Ala Arg Glu Thr Gly Asn Tyr 
1               5           


<210>  279
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 4-N22-A

<400>  279

Gln Gly Ile Ser Ser Asn 
1               5       


<210>  280
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 4-N22-A

<400>  280

His Gly Thr 
1           


<210>  281
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 4-N22-A

<400>  281

Val Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  282
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 7-B10-A

<400>  282

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Glu Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  283
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 7-B10-A

<400>  283
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc       60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtagtaa ttatgcaaga      180

tattatgccg attcagtgaa agacagattc accatttcca gagatgagtc acaaagcatg      240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgaga      300

gatcacgatt actacggtag tagttactgg tttgcttact ggggccaagg gactctggtc      360

actgtctctg ca                                                          372


<210>  284
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 7-B10-A

<400>  284

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Ser Ser Ser Gln Ser Leu Val His Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  285
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 7-B10-A

<400>  285
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gctctagtca gagccttgta cacaataatg gaaacaccta tttacattgg      120

tacctgcaga agccgggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  286
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 7-B10-A

<400>  286

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  287
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 7-B10-A

<400>  287

Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg 
1               5                   10  


<210>  288
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 7-B10-A

<400>  288

Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  289
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 7-B10-A

<400>  289

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  290
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 7-B10-A

<400>  290

Lys Val Ser 
1           


<210>  291
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 7-B10-A

<400>  291

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  292
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-H5-A

<400>  292

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Ser Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Val Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Thr Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Thr Asp Ser Ser Arg Lys Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Asp Leu His Asp Tyr Asp Gly Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  293
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-H5-A

<400>  293
caggttactc tgaaagagtc tggccctggg atattgcagt cctcccagac cctcagtctg       60

acttgttctt tgtctgggtt ttcactgagc acttctggta tgggtgtgag ctgggttcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga tgacaagcgc      180

tatacccctt ccctgaagag ccggctcaca atctccacgg attcctccag aaagcaggta      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catactactg tgctcgaaga      300

gatcttcatg attacgacgg ctggtttgct tactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  294
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-H5-A

<400>  294

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ala Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Arg Tyr Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  295
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-H5-A

<400>  295
gacattgtga tgacccagtc tcaaaaattc atgtccacag cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca aaatgtgggt actaatgtcg cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatccttcc gctacagtgg agtccctgat      180

cgcttctcag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacagct atcctctcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  296
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 8-H5-A

<400>  296

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly 
1               5                   10  


<210>  297
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 8-H5-A

<400>  297

Ile Tyr Trp Asp Asp Asp Lys 
1               5           


<210>  298
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 8-H5-A

<400>  298

Ala Arg Arg Asp Leu His Asp Tyr Asp Gly Trp Phe Ala Tyr 
1               5                   10                  


<210>  299
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 8-H5-A

<400>  299

Gln Asn Val Gly Thr Asn 
1               5       


<210>  300
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 8-H5-A

<400>  300

Ser Ala Ser 
1           


<210>  301
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 8-H5-A

<400>  301

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  302
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-G20-A

<400>  302

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Ser Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Asp Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Asp Ser Ala Trp Phe Pro Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  303
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 2-G20-A

<400>  303
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattccct agttatgttt tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat atttatcctt acaatgatgg tactaactac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aaggggagac      300

tatggtgact ccgcctggtt tccttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  304
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-G20-A

<400>  304

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Lys Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Leu Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  305
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 2-G20-A

<400>  305
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctaaaatct      180

ggggtccctg ccaggttcag tggcggtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc tcagtaggga gcttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  306
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 2-G20-A

<400>  306

Gly Tyr Thr Phe Pro Ser Tyr Val 
1               5               


<210>  307
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 2-G20-A

<400>  307

Ile Tyr Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  308
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 2-G20-A

<400>  308

Ala Arg Gly Asp Tyr Gly Asp Ser Ala Trp Phe Pro Tyr 
1               5                   10              


<210>  309
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 2-G20-A

<400>  309

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  310
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 2-G20-A

<400>  310

Leu Ala Ser 
1           


<210>  311
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 2-G20-A

<400>  311

Gln Leu Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  312
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 3-E2-A

<400>  312

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Lys Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Gly His Tyr Gly Gly Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  313
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 3-E2-A

<400>  313
gaggtccagc tgcaacaatc tggacctgaa ctggtgaagc ctggggcttc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactagctac      180

acccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag caaagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attactgtgc aagaagaggg      300

gatggtcact acgggggatt tacttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  314
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 3-E2-A

<400>  314

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Ser 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  315
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 3-E2-A

<400>  315
gacattgtgc tgacccaatc tccagcttct ttggttgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattctggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  316
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 3-E2-A

<400>  316

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  317
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 3-E2-A

<400>  317

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  318
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 3-E2-A

<400>  318

Ala Arg Arg Gly Asp Gly His Tyr Gly Gly Phe Thr Tyr 
1               5                   10              


<210>  319
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 3-E2-A

<400>  319

Glu Ser Val Asp Asn Ser Gly Ile Ser Phe 
1               5                   10  


<210>  320
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 3-E2-A

<400>  320

Ala Ala Ser 
1           


<210>  321
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 3-E2-A

<400>  321

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  322
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-K16-A

<400>  322

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Met Ser Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Asp Val Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  323
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 4-K16-A

<400>  323
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttaaagtg gatgggctgg atgagcacct actctggagt gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagcggggac      300

gtcggctact ggggccaagg caccactctc acagtctcct ca                         342


<210>  324
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-K16-A

<400>  324

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ile Tyr Pro Ser 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  325
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 4-K16-A

<400>  325
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcac tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacatct atccgtccac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  326
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 4-K16-A

<400>  326

Gly Tyr Thr Phe Thr Thr Tyr Gly 
1               5               


<210>  327
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 4-K16-A

<400>  327

Met Ser Thr Tyr Ser Gly Val Pro 
1               5               


<210>  328
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 4-K16-A

<400>  328

Ala Ser Gly Asp Val Gly Tyr 
1               5           


<210>  329
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 4-K16-A

<400>  329

Gln Asn Val Gly Thr Asn 
1               5       


<210>  330
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 4-K16-A

<400>  330

Ser Ala Ser 
1           


<210>  331
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 4-K16-A

<400>  331

Gln Gln Tyr Asn Ile Tyr Pro Ser Thr 
1               5                   


<210>  332
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 6-C19-A

<400>  332

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ser Tyr Tyr Gly Met Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  333
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 6-C19-A

<400>  333
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact gactacaaca tacactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggatat attaacccta acaatggtgg tactgactac      180

aaccagaagt tccagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atcggaagat tctgcagtct attactgtgc aagagggggg      300

ttttatggca attacgggtc ttactatggt atggacttct ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  334
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 6-C19-A

<400>  334

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Phe Cys Gln His His Tyr Gly Ile Pro Pro 
                85                  90                  95      


Glu Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  335
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 6-C19-A

<400>  335
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttat agtcatttag catggtatca gcagacacag      120

ggaaaatctc ctcacctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggagttattt ctgtcaacat cattatggta ttcctccgga gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  336
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 6-C19-A

<400>  336

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  337
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 6-C19-A

<400>  337

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  338
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 6-C19-A

<400>  338

Ala Arg Gly Gly Phe Tyr Gly Asn Tyr Gly Ser Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Phe 
    


<210>  339
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 6-C19-A

<400>  339

Glu Asn Ile Tyr Ser His 
1               5       


<210>  340
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 6-C19-A

<400>  340

Asn Ala Lys 
1           


<210>  341
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 6-C19-A

<400>  341

Gln His His Tyr Gly Ile Pro Pro Glu 
1               5                   


<210>  342
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 6-L8-A

<400>  342

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Pro Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Met His Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Ala Asn Asp Asp Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Tyr Asp Val Arg Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  343
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 6-L8-A

<400>  343
gaggttcagc tgcagcagtc tgtggcagag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacac cttctggctt caacattaaa aacacctata tgcactggat gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attaatcctg cgaatgatga tactaaatat      180

gccccgaagt tccaggacaa ggccactata actgcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccatct attactgtgt ctacgacgta      300

cggtggtatt tcgatgtctg gggcacaggg accacggtca ccgtctcctc a               351


<210>  344
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 6-L8-A

<400>  344

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  345
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 6-L8-A

<400>  345
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gggccttgta cacagtaatg ggaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttcct      300

cctacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  346
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 6-L8-A

<400>  346

Gly Phe Asn Ile Lys Asn Thr Tyr 
1               5               


<210>  347
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 6-L8-A

<400>  347

Ile Asn Pro Ala Asn Asp Asp Thr 
1               5               


<210>  348
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 6-L8-A

<400>  348

Val Tyr Asp Val Arg Trp Tyr Phe Asp Val 
1               5                   10  


<210>  349
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 6-L8-A

<400>  349

Gln Gly Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  350
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 6-L8-A

<400>  350

Lys Val Ser 
1           


<210>  351
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 6-L8-A

<400>  351

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  352
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 7-D7-A

<400>  352

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Lys Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  353
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 7-D7-A

<400>  353
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agctatgcta taagctgggt tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagta atatggcctg gtggaggcac aaattataat      180

tcagctctca aatccagact gagcatcagc aaagacaact ccaagagtca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaaatact actgtgccag aactgggtac      300

tactttgact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  354
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 7-D7-A

<400>  354

Gln Leu Ile Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Leu Ser Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile His 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  355
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 7-D7-A

<400>  355
caacttattc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctt aagtgtaaat tacatgtact ggttccagca gaagccaggc      120

acctccccca aaagatggat tcatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccatgta cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  356
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 7-D7-A

<400>  356

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  357
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 7-D7-A

<400>  357

Ile Trp Pro Gly Gly Gly Thr 
1               5           


<210>  358
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 7-D7-A

<400>  358

Ala Arg Thr Gly Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  359
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 7-D7-A

<400>  359

Leu Ser Val Asn Tyr 
1               5   


<210>  360
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 7-D7-A

<400>  360

Asp Thr Ser 
1           


<210>  361
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 7-D7-A

<400>  361

Gln Gln Trp Ser Ser Asn Pro Pro Met Tyr Thr 
1               5                   10      


<210>  362
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 7-N20-A

<400>  362

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Arg Pro Gly Asn 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met His Trp Leu Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Thr Asp Lys Ser Asp Asn Tyr Gly Ala Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Glu Met Lys Arg Leu Arg Glu Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ser Arg Asp Gly Tyr Asp Trp Tyr Phe Asp Leu Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  363
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 7-N20-A

<400>  363
caggtgcagc ttgtagagac cgggggaggc ttggtgaggc ctggaaattc tctgaaactc       60

tcctgtgtta cgtcgggatt cactttcagt aactaccgga tgcactggct tcgccagcct      120

ccagggaaga ggctggagtg gattggtata attacagaca aatctgataa ttatggagca      180

aattatgcag agtctgtgaa aggcagattc gccatttcaa gagatgattc aaaaagtagt      240

gtctatctag agatgaagag attaagagag gaagacactg ccacttattt ttgtagtaga      300

gatggttacg actggtactt cgatctctgg ggcacaggga ccacggtcac cgtctcctca      360


<210>  364
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 7-N20-A

<400>  364

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Arg Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Val 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  365
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 7-N20-A

<400>  365
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcaga       60

atcacctgta aggccagtca ggatgtggga attgttgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atcccacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  366
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 7-N20-A

<400>  366

Gly Phe Thr Phe Ser Asn Tyr Arg 
1               5               


<210>  367
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 7-N20-A

<400>  367

Ile Thr Asp Lys Ser Asp Asn Tyr Gly Ala 
1               5                   10  


<210>  368
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 7-N20-A

<400>  368

Ser Arg Asp Gly Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  369
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 7-N20-A

<400>  369

Gln Asp Val Gly Ile Val 
1               5       


<210>  370
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 7-N20-A

<400>  370

Trp Ala Ser 
1           


<210>  371
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 7-N20-A

<400>  371

Gln Gln Tyr Ser Ser Tyr Pro Thr 
1               5               


<210>  372
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-A17-A

<400>  372

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Val Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Gly Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Gly Tyr His Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  373
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-A17-A

<400>  373
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agctatgcta taagctgggt tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagta gtatggcctg gtggaggcac aaattataat      180

tcagctctca aatccagact gagcatcaac aaagacaact ccaagagtca agttttctta      240

aagatgaaca gtctgcaaac tgatgacaca ggcaggtact actgtgccag aactgggtac      300

cattttgact actggggcca aggcaccact ctcacagtct cctca                      345


<210>  374
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-A17-A

<400>  374

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Met 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  375
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-A17-A

<400>  375
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgtcagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgt      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccatgta cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  376
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 8-A17-A

<400>  376

Gly Phe Ser Leu Thr Ser Tyr Ala 
1               5               


<210>  377
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 8-A17-A

<400>  377

Val Trp Pro Gly Gly Gly Thr 
1               5           


<210>  378
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 8-A17-A

<400>  378

Ala Arg Thr Gly Tyr His Phe Asp Tyr 
1               5                   


<210>  379
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 8-A17-A

<400>  379

Ser Ser Val Ser Tyr 
1               5   


<210>  380
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 8-A17-A

<400>  380

Asp Thr Ser 
1           


<210>  381
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 8-A17-A

<400>  381

Gln Gln Trp Ser Ser Asn Pro Pro Met Tyr Thr 
1               5                   10      


<210>  382
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-H3-A

<400>  382

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  383
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-H3-A

<400>  383
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc       60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtagtaa ttatgcaaca      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cctgaaaact gaggacacgg ccatgtatta ctgtgtgaga      300

gatcacgatt actacggtag tagctactgg tttacttact ggggccaagg gactctggtc      360

actgtctctg ca                                                          372


<210>  384
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-H3-A

<400>  384

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asp 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  385
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-H3-A

<400>  385
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacgataatg gaaacaccta tttacattgg      120

ttcctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg agactgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  386
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 8-H3-A

<400>  386

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  387
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 8-H3-A

<400>  387

Ile Arg Ser Lys Ser Ser Asn Tyr Ala Thr 
1               5                   10  


<210>  388
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 8-H3-A

<400>  388

Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Thr Tyr 
1               5                   10                  15  


<210>  389
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 8-H3-A

<400>  389

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  390
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 8-H3-A

<400>  390

Lys Val Ser 
1           


<210>  391
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 8-H3-A

<400>  391

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  392
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-L17-A

<400>  392

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  393
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 8-L17-A

<400>  393
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaaggatc attgaaactc       60

tcatgtgccg cctctggttt caccttcaat acctatgcca tgcactgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtagtaa ttatgcaaga      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgaga      300

gatcacgatt actacggtag tagttactgg tttgcttact ggggccaagg gactctggtc      360

actgtctctg ca                                                          372


<210>  394
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-L17-A

<400>  394

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  395
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 8-L17-A

<400>  395
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacaataatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  396
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 8-L17-A

<400>  396

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  397
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 8-L17-A

<400>  397

Ile Arg Ser Lys Ser Ser Asn Tyr Ala Arg 
1               5                   10  


<210>  398
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 8-L17-A

<400>  398

Val Arg Asp His Asp Tyr Tyr Gly Ser Ser Tyr Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  399
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 8-L17-A

<400>  399

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  400
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 8-L17-A

<400>  400

Lys Val Ser 
1           


<210>  401
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 8-L17-A

<400>  401

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  402
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-F6-A

<400>  402

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ser Asn Phe Leu Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  403
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 9-F6-A

<400>  403
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact agctatatta tgcactgggt gaagcagaag      120

cctggacagg gccttgagtg gattggatat attcttcctt acaatgatgg tactaagtac      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctat      240

atggagctca gaagcctgac ctctgaggac tctgcggtct attactgtgc aagatggggc      300

tatagtaact ttcttgactc ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  404
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-F6-A

<400>  404

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  405
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 9-F6-A

<400>  405
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattaac aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattaggaa cctggagcaa      240

gaagacattg ccacttactt ttgccaacag ggtaatacgc ttcctccgac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  406
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 9-F6-A

<400>  406

Gly Tyr Thr Phe Thr Ser Tyr Ile 
1               5               


<210>  407
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 9-F6-A

<400>  407

Ile Leu Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  408
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 9-F6-A

<400>  408

Ala Arg Trp Gly Tyr Ser Asn Phe Leu Asp Ser 
1               5                   10      


<210>  409
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 9-F6-A

<400>  409

Gln Asp Ile Asn Asn Tyr 
1               5       


<210>  410
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 9-F6-A

<400>  410

Tyr Thr Ser 
1           


<210>  411
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 9-F6-A

<400>  411

Gln Gln Gly Asn Thr Leu Pro Pro Thr 
1               5                   


<210>  412
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-I12-A

<400>  412

Arg Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser 
            20                  25                  30          


Tyr Ile Asn Trp Val Thr Gln Arg Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asn Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Glu Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  413
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain of antibody 10-I12-A

<400>  413
cgggtccagc tacagcagtc tggacctgag ctggtgaggc ctgggacttc agtgaagata       60

tcctgcaagg cttctggcta caccttcact gactcctata taaactgggt gacgcagagg      120

cctggacagg gacttgattg gattggatgg atttttcctg gaaatgataa tacttactac      180

aatgagaagt tcgagggcaa ggccacactt actcttgaca aatcttccag tacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagatcaggg      300

ggattacgac tggggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  414
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-I12-A

<400>  414

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Arg Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly His Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Ile Leu Ile Tyr Leu Ala Ser Lys Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  415
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain of antibody 10-I12-A

<400>  415
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctcgagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggcc atagttttat tcactggtac      120

cagcagaaac caggacagcc acccaaaatc ctcatctatc ttgcatccaa gttagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggatccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaa                                   333


<210>  416
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR1 of antibody 10-I12-A

<400>  416

Gly Tyr Thr Phe Thr Asp Ser Tyr 
1               5               


<210>  417
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR2 of antibody 10-I12-A

<400>  417

Ile Phe Pro Gly Asn Asp Asn Thr 
1               5               


<210>  418
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  HC-CDR3 of antibody 10-I12-A

<400>  418

Ala Arg Ser Gly Gly Leu Arg Leu Gly Phe Ala Tyr 
1               5                   10          


<210>  419
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR1 of antibody 10-I12-A

<400>  419

Glu Ser Val Asp Ser Tyr Gly His Ser Phe 
1               5                   10  


<210>  420
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR2 of antibody 10-I12-A

<400>  420

Leu Ala Ser 
1           


<210>  421
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  LC-CDR3 of antibody 10-I12-A

<400>  421

Gln Gln Asn Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  422
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  LC of antibody B13

<400>  422

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  423
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  HC of antibody B13

<400>  423

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Gly Arg Gly Phe Ile Ala Thr Val Val Glu Val Phe Asp His Trp Gly 
            100                 105                 110         


Leu Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  424
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  LC of antibody O24

<400>  424

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Phe Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  425
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  HC of antibody O24

<400>  425

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asp Tyr Ser Asn Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


