                         SEQUENCE LISTING

<110>  Emory University
 
<120>  VASOACTIVE INTESTINAL PEPTIDE (VIP) ANTAGONISTS

<130>  10029-089WO1

<150>  63/189,507
<151>  2021-05-07

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Lys Pro Arg Arg Pro Tyr Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  2
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  X is D, V, or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  X is Y or C

<220>
<221>  MISC_FEATURE
<222>  (12)..(13)
<223>  X is R or S

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  X is M or I

<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  X is K or N

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  X is K or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(26)
<223>  X is N or M

<220>
<221>  MISC_FEATURE
<222>  (26)..(27)
<223>  X is S, or L

<400>  3

Lys Pro Arg Arg Pro Tyr Xaa Xaa Xaa Xaa Thr Xaa Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Xaa Xaa Lys Tyr Leu Xaa Xaa Ile Leu Asn 
            20                  25                  


<210>  4
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Lys Pro Arg Arg Pro Tyr Thr Asp Asn Cys Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  5
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Lys Pro Arg Arg Pro Tyr Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Leu Ile Leu Asn 
            20                  25              


<210>  6
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Lys Pro Arg Arg Pro Tyr Ala Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Asn Lys Tyr Leu Asn Leu Ile Leu Asn 
            20                  25              


<210>  7
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Lys Pro Arg Arg Pro Tyr Ala Val Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Ile Ala Val Lys Lys Tyr Leu Met Ser Ile Leu Asn 
            20                  25              


<210>  8
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Lys Pro Arg Arg Pro Tyr Ala Val Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Asn Lys Tyr Leu Met Ser Ile Leu Asn 
            20                  25              


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Lys Pro Arg Arg Pro Tyr Ala Asp Asn Cys Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Ile Ala Val Asn Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25                  


<210>  10
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Lys Pro Arg Arg Pro Tyr Thr Val Asn Tyr Thr Ser Leu Arg Lys Gln 
1               5                   10                  15      


Ile Ala Val Lys Lys Tyr Leu Met Leu Ile Leu Asn 
            20                  25              


<210>  11
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Lys Pro Arg Arg Pro Tyr Thr Asp Asn Cys Thr Ser Leu Arg Lys Gln 
1               5                   10                  15      


Ile Ala Val Asn Lys Tyr Leu Asn Leu Ile Leu Asn 
            20                  25              


<210>  12
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Lys Pro Arg Arg Pro Tyr Ala Val Asn Cys Thr Ser Leu Arg Lys Gln 
1               5                   10                  15      


Ile Ala Val Asn Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  13
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Lys Pro Arg Arg Pro Tyr Ala Val Asn Cys Thr Ser Leu Arg Lys Gln 
1               5                   10                  15      


Ile Ala Val Lys Lys Tyr Leu Met Ser Ile Leu Asn 
            20                  25              


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Lys Lys Pro Arg Arg Pro Tyr Thr Val Asn Cys Thr Ser Leu Arg Lys 
1               5                   10                  15      


Gln Ile Ala Val Lys Lys Tyr Leu Met Leu Ile Leu Asn 
            20                  25                  


<210>  15
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Lys Pro Arg Arg Pro Tyr Thr Ser Asp Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  16
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Lys Pro Arg Arg Pro Tyr Thr Ser Asp Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Leu Ile Leu Asn 
            20                  25              


<210>  17
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

His Ser Asp Ala Val Phe Ile Asn Thr Lys Leu Asp Lys Leu Asn Thr 
1               5                   10                  15      


Arg Leu Val Ser Ala Gln Asn Tyr Met Lys Tyr Arg 
            20                  25              


<210>  18
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Lys Pro Arg Arg Pro Tyr Ile Asn Thr Lys Leu Asp Lys Leu Asn Thr 
1               5                   10                  15      


Arg Leu Val Ser Ala Gln Asn Tyr Met Lys Tyr Arg 
            20                  25              


<210>  19
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Met Leu Leu Lys Leu Lys Glu Lys Ala Ser Leu Thr Leu Ala Val Gly 
1               5                   10                  15      


Thr Leu Pro Phe Pro Ser Gln Phe Asn Phe Val Pro Pro Gly Arg Met 
            20                  25                  30          


Cys Arg Val Ala Gly Trp Gly Arg Thr Gly Val Leu Lys Pro Gly Ser 
        35                  40                  45              


Asp Thr Leu Gln Glu Val Lys Leu Arg Leu Met Asp Pro Gln Ala Cys 
    50                  55                  60                  


Ser His Phe Arg Asp Phe Asp His Asn Leu Gln Leu Cys Val Gly Asn 
65                  70                  75                  80  


Pro Arg Lys Thr Lys Ser Ala Phe Lys Gly Asp Ser Gly Gly Pro Leu 
                85                  90                  95      


Leu Cys Ala Gly Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Ser Asp 
            100                 105                 110         


Ala Lys Pro Pro Ala Val Phe Thr Arg Ile Ser His Tyr Arg Pro Trp 
        115                 120                 125             


Ile Asn Gln Ile Leu Gln Ala Asn 
    130                 135     


<210>  20
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu 
1               5                   10                  15      


Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys 
            20                  25                  30          


Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser 
        35                  40                  45              


Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val 
    50                  55                  60                  


Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val 
65                  70                  75                  80  


Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile 
                85                  90                  95      


Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr 
            100                 105                 110         


Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser 
        115                 120                 125             


Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys 
    130                 135                 140                 


Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val 
145                 150                 155                 160 


Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg 
                165                 170                 175     


Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr 
            180                 185                 190         


Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg 
        195                 200                 205             


Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met 
    210                 215                 220                 


Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg 
225                 230                 235                 240 


Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln 
                245                 250                 255     


Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn 
            260                 265                 270         


Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu 
        275                 280                 285             


Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro 
    290                 295                 300                 


Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp 
305                 310                 315                 320 


Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu 
                325                 330                 335     


Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser Glu Thr 
            340                 345                 350         


Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Glu Asn 
        355                 360                 365             


Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys 
    370                 375                 380                 


His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln 
385                 390                 395                 400 


Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys Arg Ala 
                405                 410                 415     


Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro Asp Asp 
            420                 425                 430         


Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu Leu Asn 
        435                 440                 445             


Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu Lys Phe 
    450                 455                 460                 


Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp Lys Asp 
465                 470                 475                 480 


Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser Ser Gly 
                485                 490                 495     


Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro Phe Phe 
            500                 505                 510         


Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val 
        515                 520                 525             


Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg Asn Phe 
    530                 535                 540                 


Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser Ala Ser 
545                 550                 555                 560 


Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly Asn Phe 
                565                 570                 575     


Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn Thr Leu 
            580                 585                 590         


Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr Arg Ala 
        595                 600                 605             


Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu Pro Gly 
    610                 615                 620                 


Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala Gln Val 
625                 630                 635                 640 


Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile Lys Thr 
                645                 650                 655     


Asp Val Glu Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu Gln Asn 
            660                 665                 670         


Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser Tyr Met 
        675                 680                 685             


Asn Pro Glu Lys Lys Cys Arg Val Trp 
    690                 695         


<210>  21
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  X is T or A

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  X is D, V, or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  X is N or D

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  X is Y or C

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  X is R or S

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(19)
<223>  X is M or I

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  X is K or N

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (26)..(27)
<223>  X is N or M

<220>
<221>  MISC_FEATURE
<222>  (27)..(28)
<223>  X is S, or L

<400>  21

Lys Pro Arg Arg Pro Tyr Xaa Xaa Xaa Xaa Thr Xaa Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Xaa Lys Tyr Leu Xaa Xaa Ile Leu Asn 
            20                  25              


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Gly Gly Gly Gly Ser Cys 
1               5       


