               SEQUENCE LISTING

<110> Christian-Albrechts-Universität zu Kiel
      YUMAB GmbH

<120> Co-stimulatory multispecific antibodies

<130> AC3343 PCT

<150> EP 21 174 284.6
<151> 2021-05-18

<160> 56

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #3 CDR1 VH

<400> 1
Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #3 CDR2 VH

<400> 2
Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               

<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #3 CDR3 VH

<400> 3
Ala Lys Asp Leu Tyr Asp Tyr Val Trp Gly Ser Tyr Arg Pro Asn Trp 
1               5                   10                  15      
Tyr Phe Asp Leu 
            20  

<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #3 CDR1 VL

<400> 4
Ser Leu Arg Gly Tyr Tyr 
1               5       

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #3 CDR3 VL

<400> 5
Asn Ser Arg Asp Asn Asn Gly Asn Phe Val Ile 
1               5                   10      

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #32 CDR1 VH

<400> 6
Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #32 CDR2 VH

<400> 7
Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               

<210> 8
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #32 CDR3 VH

<400> 8
Ala Lys Asp Ile Tyr Asp Phe Trp Ser Gly Tyr Ile Phe Asp Tyr 
1               5                   10                  15  

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #32 CDR1 VL

<400> 9
Ser Leu Arg Ser Tyr Tyr 
1               5       

<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #32 CDR3 VL

<400> 10
Asn Ser Arg Asp Ser Ser Gly Asn His Leu Asp Val Val 
1               5                   10              

<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #35 CDR1 VH

<400> 11
Gly Phe Thr Phe Asp Asp Tyr Thr 
1               5               

<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #35 CDR2 VH

<400> 12
Ile Ser Trp Asn Ser Asn Lys Ile 
1               5               

<210> 13
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #35 CDR3 VH

<400> 13
Ala Lys Asp Leu Ser Ala Met Leu Ser Trp Gly Ile Asp Tyr 
1               5                   10                  

<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #35 CDR1 VL

<400> 14
Ser Leu Arg Ser Tyr Tyr 
1               5       

<210> 15
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #35 CDR3 VL

<400> 15
Asn Ser Arg Asp Ser Ser Gly Asn His Asp Met Val 
1               5                   10          

<210> 16
<211> 127
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #3 VH

<400> 16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Leu Tyr Asp Tyr Val Trp Gly Ser Tyr Arg Pro Asn Trp 
            100                 105                 110         
Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         

<210> 17
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #3 VL

<400> 17
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Gly Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Thr Tyr 
        35                  40                  45              
Gly Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Thr Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Asn Asn Gly Asn Phe 
                85                  90                  95      
Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             

<210> 18
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #32 VH

<400> 18
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Ile Tyr Asp Phe Trp Ser Gly Tyr Ile Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210> 19
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #32 VL

<400> 19
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      
Leu Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210> 20
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #35 VH

<400> 20
Gln Val Gln Leu Val Gln Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Asn Lys Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Leu Ser Ala Met Leu Ser Trp Gly Ile Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 21
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Clone #35 VL

<400> 21
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              
Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Glu Ala Gln Ala Glu 
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      
Asp Met Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rituximab CDR1 VH

<400> 22
Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               

<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rituximab CDR2 VH

<400> 23
Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               

<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rituximab CDR3 VH

<400> 24
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val 
1               5                   10                  

<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rituximab CDR1 VL

<400> 25
Ser Ser Val Ser Tyr 
1               5   

<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rituximab CDR3 VL

<400> 26
Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   

<210> 27
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rituximab VH

<400> 27
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly 
            100                 105                 110         
Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     

<210> 28
<211> 106
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rituximab VL

<400> 28
Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 29
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 29
Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
1               5                   10                  15      
Arg Val 
        

<210> 30
<211> 360
<212> DNA
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VH

<400> 30
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg      60

tcctgtgcag cttctggctt caacattaaa gacacctata tacactgggt gcgtcaggcc     120

ccgggtaagg gcctggaatg ggttgcaagg atttatccta cgaatggtta tactagatat     180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac     240

ctgcagatga acagcctgcg tgctgaggac actgccgtct attattgttc tagatgggga     300

ggggacggct tctatgctat ggactattgg ggtcaaggaa ccctggtcac cgtctcctcg     360


<210> 31
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VH

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VH CDR1

<400> 32
Gly Phe Asn Ile 
1               

<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VH CDR2

<400> 33
Ile Tyr Pro Thr Asn Gly Tyr Thr 
1               5               

<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VH CDR3

<400> 34
Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10              

<210> 35
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VL

<400> 35
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc      60

atcacctgcc gtgccagtca ggatgtgaat actgctgtag cctggtatca acagaaacca     120

ggaaaagctc cgaaactact gatttactcg gcatccttcc tctattctgg agtcccttct     180

cgcttctctg gatccagatc tgggacggat ttcactctga ccatcagcag tctgcagccg     240

gaagacttcg caacttatta ctgtcagcaa cattatacta ctcctcccac gttcggacag     300

ggtaccaagg tggagatcaa a                                               321


<210> 36
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VL

<400> 36
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VL CDR1

<400> 37
Gln Asp Val Asn Thr Ala 
1               5       

<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4D5 (Trastuzumab) VL CDR3

<400> 38
Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   

<210> 39
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD138 VH

<400> 39
caggtgcagc tgcagcagtc tggatccgag ctgatgatgc ctggggcctc agtgaagata      60

tcctgcaagg ctactggcta cacattcagt aactactgga tagagtgggt aaagcagagg     120

cctggacatg gccttgagtg gattggagag attttacctg gaacaggtag gactatatac     180

aatgagaagt tcaagggcaa ggccacattc actgcagata tttcctccaa cacagtccag     240

atgcaactca gcagcctgac atctgaggac tctgccgtct attactgtgc aagaagggac     300

tattacggca acttctacta tgctatggac tactggggcc aagggaccag cgtcaccgtc     360

tcctcg                                                                366


<210> 40
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD138 VH

<400> 40
Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Met Met Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          
Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Leu Pro Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Phe Thr Ala Asp Ile Ser Ser Asn Thr Val Gln 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Asp Tyr Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         

<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD138 VH CDR1

<400> 41
Gly Tyr Thr Phe Ser Asn Tyr Trp 
1               5               

<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD138 VH CDR2

<400> 42
Ile Leu Pro Gly Thr Gly Arg Thr 
1               5               

<210> 43
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD138 VH CDR3

<400> 43
Ala Arg Arg Asp Tyr Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  

<210> 44
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD138 VL

<400> 44
gatatccaga tgacacagtc tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      60

atcagttgca gtgcaagtca gggcattaac aattatttaa actggtatca gcagaaacca     120

gatggaactg ttgaactcct gatctattac acatcaactt tacagtcagg agtcccatca     180

aggttcagtg gcagtgggtc tgggacagat tattctctca ccatcagcaa cctggaacct     240

gaagatattg gcacttacta ttgtcagcag tatagtaagc ttcctaggac gttcggtgga     300

ggcaccaagc tggaaatcaa a                                               321


<210> 45
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD138 VL

<400> 45
Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD138 VL CDR1

<400> 46
Gln Gly Ile Asn Asn Tyr 
1               5       

<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD138 VL CDR3

<400> 47
Gln Gln Tyr Ser Lys Leu Pro Arg Thr 
1               5                   

<210> 48
<211> 357
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VH

<400> 48
gaggtgcagc ttgtcgagtc tggaggtggc ctggtgcagc ctggaggatc cctgagactc      60

tcctgtgcag cctcaggatt cgattttagt agatactgga tgagttgggt ccggcaggct     120

ccagggaaag ggctagaatg gattggagaa attaatccag atagcagtac gataaactat     180

gcgccatctc taaaggataa attcatcatc tccagagaca acgccaaaaa tagcctgtac     240

ctgcaaatga acagtctgag agctgaggac acagccgttt attactgtgc aagacctgat     300

gggaactatt ggtacttcga tgtctggggc cagggcaccc tggtcaccgt ctcctca        357


<210> 49
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VH

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 50
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VH CDR1

<400> 50
Gly Phe Asp Phe Ser Arg Tyr Trp 
1               5               

<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VH CDR2

<400> 51
Ile Asn Pro Asp Ser Ser Thr Ile 
1               5               

<210> 52
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VH CDR3

<400> 52
Ala Arg Pro Asp Gly Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10          

<210> 53
<211> 321
<212> DNA
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VL

<400> 53
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      60

atcacttgca aggcgagtca ggacgttggc attgctgtag cctggtatca gcagaaacca     120

gggaaagttc ctaaactcct gatctattgg gcatccactc ggcacacagg agtcccagat     180

cggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct     240

gaagatgttg caacttatta ctgtcaacag tatagcagtt acccgtacac ttttggccag     300

gggaccaagg tggagatcaa a                                               321


<210> 54
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VL

<400> 54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ile Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 55
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VL CDR1

<400> 55
Gln Asp Val Gly Ile Ala 
1               5       

<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CD319 (CS-1) VL CDR3

<400> 56
Gln Gln Tyr Ser Ser Tyr Pro Tyr Thr 
1               5                   

