                         SEQUENCE LISTING

<110>  Pieris Pharmaceuticals GmbH
 
<120>  Lipocalin muteins with binding affinity for OX40

<130>  PIE17273PCT (P051 PCT)

<150>  EP 21174312.5
<151>  2021-05-18

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  human

<400>  1

His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr 
1               5                   10                  15      


Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn 
            20                  25                  30          


Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn 
        35                  40                  45              


Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val 
    50                  55                  60                  


Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp 
65                  70                  75                  80  


Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His 
                85                  90                  95      


Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val Arg Gly 
            100                 105                 110         


Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu 
        115                 120                 125             


Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile 
    130                 135                 140                 


Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
145                 150                 155             


<210>  2
<211>  178
<212>  PRT
<213>  human

<400>  2

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  3
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  3

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Glu Cys Pro Glu Met Asn Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Leu Ile Ser Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys His Gly Lys Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  4
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  4

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  5
<211>  4
<212>  PRT
<213>  human

<400>  5

His His Leu Leu 
1               


<210>  6
<211>  272
<212>  PRT
<213>  human

<400>  6

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
    210                 215                 220                 


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
225                 230                 235                 240 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
                245                 250                 255     


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
            260                 265                 270         


<210>  7
<211>  249
<212>  PRT
<213>  human

<400>  7

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly 
            180                 185                 190         


Leu Gly Leu Val Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala 
        195                 200                 205             


Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys 
    210                 215                 220                 


Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
225                 230                 235                 240 


Asp Ala His Ser Thr Leu Ala Lys Ile 
                245                 


<210>  8
<211>  272
<212>  PRT
<213>  cynomolgus monkey

<400>  8

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Thr Ser Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Asn Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Gln Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Arg Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Ile 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala Leu Pro Pro Asn Glu Arg Thr His Leu Val 
    210                 215                 220                 


Ile Leu Gly Ala Ile Phe Leu Leu Leu Gly Val Ala Leu Thr Phe Ile 
225                 230                 235                 240 


Phe Tyr Leu Arg Lys Gly Arg Met Met Asp Met Lys Lys Ser Gly Ile 
                245                 250                 255     


Arg Val Thr Asn Ser Lys Lys Gln Arg Asp Thr Gln Leu Glu Glu Thr 
            260                 265                 270         


<210>  9
<211>  249
<212>  PRT
<213>  cynomolgus monkey

<400>  9

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala Val Ala Ala Ile Leu Gly 
            180                 185                 190         


Leu Gly Leu Ala Leu Gly Leu Leu Gly Pro Leu Ala Met Leu Leu Ala 
        195                 200                 205             


Leu Leu Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala Pro Lys 
    210                 215                 220                 


Ala Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala 
225                 230                 235                 240 


Asp Ala His Ser Ala Leu Ala Lys Ile 
                245                 


<210>  10
<211>  4
<212>  PRT
<213>  human

<400>  10

Ile Glu Gly Arg 
1               


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion peptide

<400>  11

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  strep tag II

<400>  12

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  14

Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser 
1               5                   10                  15      


Pro Ser 
        


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  15

Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val 
1               5                   10                  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  16

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


<210>  17
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val Pro Ser 
        35                  40                  45              


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
    50                  55                  60                  


Ala Ser 
65      


<210>  18
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  18

Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
1               5                   10                  15      


Pro Ser Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val 
            20                  25                  30          


<210>  19
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  19

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr 
        35                  40                  45              


Pro Ser Pro Ser Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser 
    50                  55                  60                  


Thr Pro Pro Thr Pro Ser Pro Ser Ala Ser 
65                  70                  


<210>  20
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            20                  25                  30          


Ala Pro Ala Pro Ser Ala Pro Ala 
        35                  40  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  21

Val Asp Asp Ile Glu Gly Arg Met Asp Glu 
1               5                   10  


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  22

Glu Asn Leu Tyr Phe Gln Gly Arg Met Asp Glu 
1               5                   10      


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  24
<211>  327
<212>  PRT
<213>  human

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  25
<211>  214
<212>  PRT
<213>  human

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Trp Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  27
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  28
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  28

Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr Ala 
            20                  25                  30          


Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Ala Ile Asp Thr Asp Ala Gly Thr Phe Tyr Ala Asp Ser Val Arg Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      


Leu Gly Glu Gly Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  29
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  30
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile His Pro Lys Ser Gly Asn Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Glu Tyr Ser Asn Phe Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  31
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody light chain

<400>  31

Asp Ile Val Leu Thr Gln Ser Pro Thr Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Thr Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  32
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody Fc region

<400>  32

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  33
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody Fc region

<400>  33

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  34
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody Fc region

<400>  34

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  35
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody Fc region

<400>  35

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  36
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  36

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  37
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  37

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Gln Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Asp 
            20                  25                  30          


Thr Pro Met Ile Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Thr Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Met Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  38
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  38

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Met Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Met Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  39
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  39

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Glu 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Met Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala His Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  40
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  40

Ala Thr Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Val 
            20                  25                  30          


Ala Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Ile Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Thr Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val Trp Leu Ala 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  41
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  41

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Asp 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Ser 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  42
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  42

Ala Ser Asp Lys Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Asp 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Leu Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Met Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  43
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  43

Ala Ser Asp Glu Glu Ile Arg Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Asp 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Arg Thr Glu Ser Ile Leu Ile Pro Trp 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  44
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  44

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Asp 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  45
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  45

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Asp 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Ser Gly Lys Tyr Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys His Gly Ile Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Lys Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  46
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  46

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe Asp Ser Asp 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Ile Phe Ile Asp Gly Lys Cys Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  47
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  47

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  48
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  48

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Lys Lys Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Gly Val Leu Phe Pro His Lys Glu Cys His Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Leu Val Pro Gly Ile Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  49
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  49

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Thr Tyr 
    50                  55                  60                  


Asn Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  50
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  50

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Glu Met Gln Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His Tyr Asp Thr 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Arg Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Arg Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  51
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  51

Gln Asp Phe Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Val Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Leu Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Arg Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln Tyr Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Gly Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  52
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  52

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Gly Asp Lys Asp Pro 
        35                  40                  45              


Gly Thr Met Gln Ala Thr Ile Tyr Glu Leu Lys Glu Asp Arg Ser Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Leu Phe Pro His Lys Glu Cys His Tyr Asp Thr 
65                  70                  75                  80  


Val Ile Leu Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  53
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  53

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Glu Met Gln Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Arg Phe Pro His Lys Glu Cys His Tyr Asp Thr 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln Tyr Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asp Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  54
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  54

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Asn Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His Tyr Asp Ile 
65                  70                  75                  80  


Val Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  55
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  55

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His Asp Asp Ile 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Ala Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  56
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  56

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His Asp Asp Ile 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Ala Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  57
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  57

Gln Asp Pro Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Glu Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His Tyr Asp Thr 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  58
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  58

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Arg Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His His Asp Thr 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  59
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  59

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asp Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His Asp Asp Thr 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  60
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  60

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Pro Phe Pro His Lys Glu Cys His Tyr Asp Thr 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asp Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  61
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  61

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Glu Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Arg Val Thr Gly Val Pro Phe Pro His Lys Glu Cys His Tyr Asp Ile 
65                  70                  75                  80  


Val Val Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Ala Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asp Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Ala Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  62
<211>  531
<212>  DNA
<213>  human

<400>  62
atgaagcccc tgctcctggc cgtcagcctt ggcctcattg ctgccctgca ggcccaccac       60

ctcctggcct cagacgagga gattcaggat gtgtcaggga cgtggtatct gaaggccatg      120

acggtggaca gggagttccc tgagatgaat ctggaatcgg tgacacccat gaccctcacg      180

accctggaag ggggcaacct ggaagccaag gtcaccatgc tgataagtgg ccggtgccag      240

gaggtgaagg ccgtcctgga gaaaactgac gagccgggaa aatacacggc cgacgggggc      300

aagcacgtgg catacatcat caggtcgcac gtgaaggacc actacatctt ttactgtgag      360

ggcgagctgc acgggaagcc ggtccgaggg gtgaagctcg tgggcagaga ccccaagaac      420

aacctggaag ccttggagga ctttgagaaa gccgcaggag cccgcggact cagcacggag      480

agcatcctca tccccaggca gagcgaaacc tgctctccag ggagcgatta g               531


<210>  63
<211>  597
<212>  DNA
<213>  human

<400>  63
atgcccctag gtctcctgtg gctgggccta gccctgttgg gggctctgca tgcccaggcc       60

caggactcca cctcagacct gatcccagcc ccacctctga gcaaggtccc tctgcagcag      120

aacttccagg acaaccaatt ccaggggaag tggtatgtgg taggcctggc agggaatgca      180

attctcagag aagacaaaga cccgcaaaag atgtatgcca ccatctatga gctgaaagaa      240

gacaagagct acaatgtcac ctccgtcctg tttaggaaaa agaagtgtga ctactggatc      300

aggacttttg ttccaggttg ccagcccggc gagttcacgc tgggcaacat taagagttac      360

cctggattaa cgagttacct cgtccgagtg gtgagcacca actacaacca gcatgctatg      420

gtgttcttca agaaagtttc tcaaaacagg gagtacttca agatcaccct ctacgggaga      480

accaaggagc tgacttcgga actaaaggag aacttcatcc gcttctccaa atctctgggc      540

ctccctgaaa accacatcgt cttccctgtc ccaatcgacc agtgtatcga cggctga         597


<210>  64
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  64

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Gly Asp 
        275                 280                 285             


Lys Asp Pro Gly Thr Met Gln Ala Thr Ile Tyr Glu Leu Lys Glu Asp 
    290                 295                 300                 


Arg Ser Tyr Gln Val Thr Gly Val Leu Phe Pro His Lys Glu Cys His 
305                 310                 315                 320 


Tyr Asp Thr Val Ile Leu Val Pro Gly Ser Gln Pro Gly Glu Phe Thr 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


<210>  65
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  65

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Trp Leu Arg Glu Asp 
        275                 280                 285             


Lys Asp Pro Gly Glu Met Gln Ala Thr Ile Tyr Glu Leu Lys Glu Asp 
    290                 295                 300                 


Lys Ser Tyr Gln Val Thr Gly Val Arg Phe Pro His Lys Glu Cys His 
305                 310                 315                 320 


Tyr Asp Thr Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asp Tyr Asn Gln Tyr Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asp Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


<210>  66
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  66

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp 
        275                 280                 285             


Lys Asp Pro Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp 
    290                 295                 300                 


Lys Ala Tyr Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His 
305                 310                 315                 320 


Asp Asp Ile Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Ala Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


<210>  67
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  67

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp 
        275                 280                 285             


Lys Asp Pro Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp 
    290                 295                 300                 


Lys Ala Tyr Gln Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His 
305                 310                 315                 320 


Asp Asp Ile Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Ala Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


<210>  68
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  68

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Ser Arg Phe Gln Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp 
        275                 280                 285             


Lys Asp Pro Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp 
    290                 295                 300                 


Lys Ala Tyr Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His 
305                 310                 315                 320 


His Asp Thr Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


<210>  69
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  69

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ser Asp Glu Glu Ile Arg Asp Val Ser Gly Thr Trp 
                245                 250                 255     


Tyr Leu Lys Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe 
            260                 265                 270         


Asp Ser Asp Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        275                 280                 285             


Glu Ala Lys Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys 
    290                 295                 300                 


Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly 
305                 310                 315                 320 


Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr 
                325                 330                 335     


Ile Phe Tyr Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val 
            340                 345                 350         


Trp Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp 
        355                 360                 365             


Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Arg Thr Glu Ser Ile Leu 
    370                 375                 380                 


Ile Pro Trp Gln Ser Glu Thr Ser Ser Pro Gly 
385                 390                 395 


<210>  70
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  70

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ser Asp Lys Glu Ile Gln Asp Val Ser Gly Thr Trp 
                245                 250                 255     


Tyr Leu Lys Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe 
            260                 265                 270         


Asp Ser Asp Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        275                 280                 285             


Glu Ala Lys Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys 
    290                 295                 300                 


Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly 
305                 310                 315                 320 


Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr 
                325                 330                 335     


Ile Phe Tyr Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Leu 
            340                 345                 350         


Trp Leu Val Gly Arg Asp Pro Met Asn Asn Leu Glu Ala Leu Glu Asp 
        355                 360                 365             


Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu 
    370                 375                 380                 


Ile Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly 
385                 390                 395 


<210>  71
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  71

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp 
                245                 250                 255     


Tyr Leu Lys Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe 
            260                 265                 270         


Asp Ser Asp Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        275                 280                 285             


Glu Ala Lys Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys 
    290                 295                 300                 


Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly 
305                 310                 315                 320 


Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr 
                325                 330                 335     


Ile Phe Tyr Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val 
            340                 345                 350         


Trp Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp 
        355                 360                 365             


Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu 
    370                 375                 380                 


Ile Pro Ser Gln Ser Glu Thr Ser Ser Pro Gly 
385                 390                 395 


<210>  72
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  72

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp 
                245                 250                 255     


Tyr Leu Lys Ala Met Lys Val Asp Trp Asp Cys Asn Gln Pro Ile Phe 
            260                 265                 270         


Asp Ser Asp Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu 
        275                 280                 285             


Glu Ala Lys Val Thr Ile Phe Ile Asp Gly Lys Tyr Gln Glu Val Lys 
    290                 295                 300                 


Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly 
305                 310                 315                 320 


Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr 
                325                 330                 335     


Ile Phe Tyr Ser Glu Gly Gln Cys Pro Gly Ile Pro Val Pro Gly Val 
            340                 345                 350         


Trp Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp 
        355                 360                 365             


Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu 
    370                 375                 380                 


Ile Pro Arg Gln Ser Glu Thr Ser Ser Pro Gly 
385                 390                 395 


<210>  73
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  73

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His Asp Asp Ile 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  74
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  74

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His Asp Asp Thr 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  75
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  75

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp Lys Ala Tyr 
    50                  55                  60                  


Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His Asp Asp Thr 
65                  70                  75                  80  


Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile Leu Gly Trp 
                85                  90                  95      


Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp Val Phe Gln 
        115                 120                 125             


Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  76
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  76

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp 
        275                 280                 285             


Lys Asp Pro Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp 
    290                 295                 300                 


Lys Ala Tyr Gln Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His 
305                 310                 315                 320 


Asp Asp Ile Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


<210>  77
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  77

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp 
        275                 280                 285             


Lys Asp Pro Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp 
    290                 295                 300                 


Lys Ala Tyr Gln Val Thr Gly Val Leu Phe Pro His Lys Lys Cys His 
305                 310                 315                 320 


Asp Asp Thr Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


<210>  78
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  78

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu 
                245                 250                 255     


Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Ser Gln Phe Gln Gly 
            260                 265                 270         


Lys Trp Tyr Val Val Gly Phe Ala Gly Asn Tyr Arg Leu Arg Glu Asp 
        275                 280                 285             


Lys Asp Pro Gly Lys Met Gln Ala Thr Ile Tyr Glu Leu Arg Glu Asp 
    290                 295                 300                 


Lys Ala Tyr Gln Val Thr Gly Val Pro Phe Pro His Lys Lys Cys His 
305                 310                 315                 320 


Asp Asp Thr Val Ile Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Ile 
                325                 330                 335     


Leu Gly Trp Ile Lys Ser Asp Pro Gly Ile Thr Ser Asp Leu Val Arg 
            340                 345                 350         


Val Val Ser Thr Asp Tyr Asn Gln His Ala Met Val Phe Phe Lys Trp 
        355                 360                 365             


Val Phe Gln Asn Arg Glu Trp Phe Tyr Ile Thr Leu Tyr Gly Arg Thr 
    370                 375                 380                 


Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys 
385                 390                 395                 400 


Ser Leu Gly Leu Pro Glu Asp His Ile Val Phe Pro Val Pro Ile Asp 
                405                 410                 415     


Gln Cys Ile Asp Gly 
            420     


