                         SEQUENCE LISTING

<110>  The University of York
 
<120>  Glycosylation Method

<130>  4846P/GB

<150>  GB2107057.8
<151>  2021-05-18

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcggacc ttgattcgcc tccgaagctg tcaggggtgc agcagccgtc tgagggggtg       60

ggaggtggcc gctgctccga aatctccgct gagctcattc gctccctgac agagctgcag      120

gagctggagg ctgtatacga acggctctgc ggcgaggaga aagtggtgga gagagagctg      180

gatgctcttt tggaacagca aaacaccatt gaaagtaaga tggtcactct ccaccgaatg      240

ggtcctaatc tgcagctgat tgagggagat gcaaagcagc tggctggaat gatcaccttt      300

acctgcaacc tggctgagaa tgtgtccagc aaagttcgtc agcttgacct ggccaagaac      360

cgcctctatc aggccattca gagagctgat gacatcttgg acctgaagtt ctgcatggat      420

ggagttcaga ctgctttgag gagtgaagat tatgagcagg ctgcagcaca tattcatcgc      480

tacttgtgcc tggacaagtc ggtcattgag ctcagccgac agggcaaaga ggggagcatg      540

attgatgcca acctgaaatt gctgcaggaa gctgagcaac gtctcaaagc cattgtggca      600

gagaagtttg ccattgccac caaggaaggt gatttgcccc aggtggagcg cttcttcaag      660

atcttcccac tgctgggttt gcatgaggag ggattaagaa agttctcgga gtacctttgc      720

aagcaggtgg ccagtaaagc tgaggagaat ctgctcatgg tgctggggac agacatgagt      780

gatcggagag ctgcagtcat ctttgcagat acacttactc ttctgtttga agggattgcc      840

cgcattgtgg agacccacca gccaatagtg gagacctatt atgggccagg gagactctat      900

accctgatca aatatctgca ggtggaatgt gacagacagg tggagaaggt ggtagacaag      960

ttcatcaagc aaagggacta ccaccagcag ttccggcatg ttcagaacaa cctgatgaga     1020

aattctacaa cagaaaaaat cgaaccaaga gaactggacc ccatcctgac tgaggtcacc     1080

ctgatgaatg cccgcagtga gctatactta cgcttcctca agaagaggat tagctctgat     1140

tttgaggtgg gagactccat ggcctcagag gaagtaaagc aagagcacca gaagtgtctg     1200

gacaaactcc tcaataactg ccttttgagc tgtaccatgc aggagctaat tggcttatat     1260

gttaccatgg aggagtactt catgagggag actgtcaata aggctgtggc tctggacacc     1320

tatgagaagg gccagctgac atccagcatg gtggatgatg tcttctacat tgttaagaag     1380

tgcattgggc gggctctgtc cagctccagc attgactgtc tctgtgccat gatcaacctc     1440

gccaccacag agctggagtc tgacttcagg gatgttctgt gtaataagct gcggatgggc     1500

tttcctgcca ccaccttcca ggacatccag cgcggggtga caagtgccgt gaacatcatg     1560

cacagcagcc tccagcaagg caaatttgac acaaaaggca tcgagagtac tgacgaggcg     1620

aagatgtcct tcctggtgac tctgaacaac gtggaagtct gcagtgaaaa catctccact     1680

ctgaagaaga cactggagag tgactgcacc aagctcttca gccagggcat tggaggggag     1740

caggcccagg ccaagtttga cagctgcctt tctgacttgg ccgccgtgtc caacaaattc     1800

cgagacctct tgcaggaagg gctgacggag ctcaacagca cagccatcaa gccacaggtg     1860

cagccttgga tcaacagctt tttctccgtc tcccacaaca tcgaggagga agaattcaat     1920

gactatgagg ccaacgaccc ttgggtacaa cagttcatcc ttaacctgga gcagcaaatg     1980

gcagagttca aggccagcct gtccccggtc atctacgaca gcctaaccgg cctcatgact     2040

agccttgttg ccgtcgagtt ggagaaagtg gtgctgaaat ccacctttaa ccggctgggt     2100

ggtctgcagt ttgacaagga gctgaggtcg ctcattgcct accttaccac ggtgaccacc     2160

tggaccatcc gagacaagtt tgcccggctc tcccagatgg ccaccatcct caatctggag     2220

cgggtgaccg agatcctcga ttactgggga cccaattccg gcccattgac gtggcgcctc     2280

acccctgctg aagtgcgcca ggtgctggcc ctgcggatag acttccgcag tgaagatatc     2340

aagaggctgc gcctgtag                                                   2358


<210>  2
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Leu Asp Ser Pro Pro Lys Leu Ser Gly Val Gln Gln Pro 
1               5                   10                  15      


Ser Glu Gly Val Gly Gly Gly Arg Cys Ser Glu Ile Ser Ala Glu Leu 
            20                  25                  30          


Ile Arg Ser Leu Thr Glu Leu Gln Glu Leu Glu Ala Val Tyr Glu Arg 
        35                  40                  45              


Leu Cys Gly Glu Glu Lys Val Val Glu Arg Glu Leu Asp Ala Leu Leu 
    50                  55                  60                  


Glu Gln Gln Asn Thr Ile Glu Ser Lys Met Val Thr Leu His Arg Met 
65                  70                  75                  80  


Gly Pro Asn Leu Gln Leu Ile Glu Gly Asp Ala Lys Gln Leu Ala Gly 
                85                  90                  95      


Met Ile Thr Phe Thr Cys Asn Leu Ala Glu Asn Val Ser Ser Lys Val 
            100                 105                 110         


Arg Gln Leu Asp Leu Ala Lys Asn Arg Leu Tyr Gln Ala Ile Gln Arg 
        115                 120                 125             


Ala Asp Asp Ile Leu Asp Leu Lys Phe Cys Met Asp Gly Val Gln Thr 
    130                 135                 140                 


Ala Leu Arg Ser Glu Asp Tyr Glu Gln Ala Ala Ala His Ile His Arg 
145                 150                 155                 160 


Tyr Leu Cys Leu Asp Lys Ser Val Ile Glu Leu Ser Arg Gln Gly Lys 
                165                 170                 175     


Glu Gly Ser Met Ile Asp Ala Asn Leu Lys Leu Leu Gln Glu Ala Glu 
            180                 185                 190         


Gln Arg Leu Lys Ala Ile Val Ala Glu Lys Phe Ala Ile Ala Thr Lys 
        195                 200                 205             


Glu Gly Asp Leu Pro Gln Val Glu Arg Phe Phe Lys Ile Phe Pro Leu 
    210                 215                 220                 


Leu Gly Leu His Glu Glu Gly Leu Arg Lys Phe Ser Glu Tyr Leu Cys 
225                 230                 235                 240 


Lys Gln Val Ala Ser Lys Ala Glu Glu Asn Leu Leu Met Val Leu Gly 
                245                 250                 255     


Thr Asp Met Ser Asp Arg Arg Ala Ala Val Ile Phe Ala Asp Thr Leu 
            260                 265                 270         


Thr Leu Leu Phe Glu Gly Ile Ala Arg Ile Val Glu Thr His Gln Pro 
        275                 280                 285             


Ile Val Glu Thr Tyr Tyr Gly Pro Gly Arg Leu Tyr Thr Leu Ile Lys 
    290                 295                 300                 


Tyr Leu Gln Val Glu Cys Asp Arg Gln Val Glu Lys Val Val Asp Lys 
305                 310                 315                 320 


Phe Ile Lys Gln Arg Asp Tyr His Gln Gln Phe Arg His Val Gln Asn 
                325                 330                 335     


Asn Leu Met Arg Asn Ser Thr Thr Glu Lys Ile Glu Pro Arg Glu Leu 
            340                 345                 350         


Asp Pro Ile Leu Thr Glu Val Thr Leu Met Asn Ala Arg Ser Glu Leu 
        355                 360                 365             


Tyr Leu Arg Phe Leu Lys Lys Arg Ile Ser Ser Asp Phe Glu Val Gly 
    370                 375                 380                 


Asp Ser Met Ala Ser Glu Glu Val Lys Gln Glu His Gln Lys Cys Leu 
385                 390                 395                 400 


Asp Lys Leu Leu Asn Asn Cys Leu Leu Ser Cys Thr Met Gln Glu Leu 
                405                 410                 415     


Ile Gly Leu Tyr Val Thr Met Glu Glu Tyr Phe Met Arg Glu Thr Val 
            420                 425                 430         


Asn Lys Ala Val Ala Leu Asp Thr Tyr Glu Lys Gly Gln Leu Thr Ser 
        435                 440                 445             


Ser Met Val Asp Asp Val Phe Tyr Ile Val Lys Lys Cys Ile Gly Arg 
    450                 455                 460                 


Ala Leu Ser Ser Ser Ser Ile Asp Cys Leu Cys Ala Met Ile Asn Leu 
465                 470                 475                 480 


Ala Thr Thr Glu Leu Glu Ser Asp Phe Arg Asp Val Leu Cys Asn Lys 
                485                 490                 495     


Leu Arg Met Gly Phe Pro Ala Thr Thr Phe Gln Asp Ile Gln Arg Gly 
            500                 505                 510         


Val Thr Ser Ala Val Asn Ile Met His Ser Ser Leu Gln Gln Gly Lys 
        515                 520                 525             


Phe Asp Thr Lys Gly Ile Glu Ser Thr Asp Glu Ala Lys Met Ser Phe 
    530                 535                 540                 


Leu Val Thr Leu Asn Asn Val Glu Val Cys Ser Glu Asn Ile Ser Thr 
545                 550                 555                 560 


Leu Lys Lys Thr Leu Glu Ser Asp Cys Thr Lys Leu Phe Ser Gln Gly 
                565                 570                 575     


Ile Gly Gly Glu Gln Ala Gln Ala Lys Phe Asp Ser Cys Leu Ser Asp 
            580                 585                 590         


Leu Ala Ala Val Ser Asn Lys Phe Arg Asp Leu Leu Gln Glu Gly Leu 
        595                 600                 605             


Thr Glu Leu Asn Ser Thr Ala Ile Lys Pro Gln Val Gln Pro Trp Ile 
    610                 615                 620                 


Asn Ser Phe Phe Ser Val Ser His Asn Ile Glu Glu Glu Glu Phe Asn 
625                 630                 635                 640 


Asp Tyr Glu Ala Asn Asp Pro Trp Val Gln Gln Phe Ile Leu Asn Leu 
                645                 650                 655     


Glu Gln Gln Met Ala Glu Phe Lys Ala Ser Leu Ser Pro Val Ile Tyr 
            660                 665                 670         


Asp Ser Leu Thr Gly Leu Met Thr Ser Leu Val Ala Val Glu Leu Glu 
        675                 680                 685             


Lys Val Val Leu Lys Ser Thr Phe Asn Arg Leu Gly Gly Leu Gln Phe 
    690                 695                 700                 


Asp Lys Glu Leu Arg Ser Leu Ile Ala Tyr Leu Thr Thr Val Thr Thr 
705                 710                 715                 720 


Trp Thr Ile Arg Asp Lys Phe Ala Arg Leu Ser Gln Met Ala Thr Ile 
                725                 730                 735     


Leu Asn Leu Glu Arg Val Thr Glu Ile Leu Asp Tyr Trp Gly Pro Asn 
            740                 745                 750         


Ser Gly Pro Leu Thr Trp Arg Leu Thr Pro Ala Glu Val Arg Gln Val 
        755                 760                 765             


Leu Ala Leu Arg Ile Asp Phe Arg Ser Glu Asp Ile Lys Arg Leu Arg 
    770                 775                 780                 


Leu 
785 


<210>  3
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcggacc ttgattcgcc tccgaagctg tcaggggtgc agcagccgtc tgagggggtg       60

ggaggtggcc gctgctccga aatctccgct gagctcattc gctccccgac agagctgcag      120

gagctggagg ctgtatacga acggctctgc ggcgaggaga aagtggtgga gagagagctg      180

gatgctcttt tggaacagca aaacaccatt gaaagtaaga tggtcactct ccaccgaatg      240

ggtcctaatc tgcagctgat tgagggagat gcaaagcagc tggctggaat gatcaccttt      300

acctgcaacc tggctgagaa tgtgtccagc aaagttcgtc agcttgacct ggccaagaac      360

cgcctctatc aggccattca gagagctgat gacatcttgg acctgaagtt ctgcatggat      420

ggagttcaga ctgctttgag gagtgaagat tatgagcagg ctgcagcaca tattcatcgc      480

tacttgtgcc tggacaagtc ggtcattgag ctcagccgac agggcaaaga ggggagcatg      540

attgatgcca acctgaaatt gctgcaggaa gctgagcaac gtctcaaagc cattgtggca      600

gagaagtttg ccattgccac caaggaaggt gatttgcccc aggtggagcg cttcttcaag      660

atcttcccac tgctgggttt gcatgaggag ggattaagaa agttctcgga gtacctttgc      720

aagcaggtgg ccagtaaagc tgaggagaat ctgctcatgg tgctggggac agacatgagt      780

gatcggagag ctgcagtcat ctttgcagat acacttactc ttctgtttga agggattgcc      840

cgcattgtgg agacccacca gccaatagtg gagacctatt atgggccagg gagactctat      900

accctgatca aatatctgca ggtggaatgt gacagacagg tggagaaggt ggtagacaag      960

ttcatcaagc aaagggacta ccaccagcag ttccggcatg ttcagaacaa cctgatgaga     1020

aattctacaa cagaaaaaat cgaaccaaga gaactggacc ccatcctgac tgaggtcacc     1080

ctgatgaatg cccgcagtga gctatactta cgcttcctca agaagaggat tagctctgat     1140

tttgaggtgg gagactccat ggcctcagag gaagtaaagc aagagcacca gaagtgtctg     1200

gacaaactcc tcaataactg ccttttgagc tgtaccatgc aggagctaat tggcttatat     1260

gttaccatgg aggagtactt catgagggag actgtcaata aggctgtggc tctggacacc     1320

tatgagaagg gccagctgac atccagcatg gtggatgatg tcttctacat tgttaagaag     1380

tgcattgggc gggctctgtc cagctccagc attgactgtc tctgtgccat gatcaacctc     1440

gccaccacag agctggagtc tgacttcagg gatgttctgt gtaataagct gcggatgggc     1500

tttcctgcca ccaccttcca ggacatccag cgcggggtga caagtgccgt gaacatcatg     1560

cacagcagcc tccagcaagg caaatttgac acaaaaggca tcgagagtac tgacgaggcg     1620

aagatgtcct tcctggtgac tctgaacaac gtggaagtct gcagtgaaaa catctccact     1680

ctgaagaaga cactggagag tgactgcacc aagctcttca gccagggcat tggaggggag     1740

caggcccagg ccaagtttga cagctgcctt tctgacttgg ccgccgtgtc caacaaattc     1800

cgagacctct tgcaggaagg gctgacggag ctcaacagca cagccatcaa gccacaggtg     1860

cagccttgga tcaacagctt tttctccgtc tcccacaaca tcgaggagga agaattcaat     1920

gactatgagg ccaacgaccc ttgggtacaa cagttcatcc ttaacctgga gcagcaaatg     1980

gcagagttca aggccagcct gtccccggtc atctacgaca gcctaaccgg cctcatgact     2040

agccttgttg ccgtcgagtt ggagaaagtg gtgctgaaat ccacctttaa ccggctgggt     2100

ggtctgcagt ttgacaagga gctgaggtcg ctcattgcct accttaccac ggtgaccacc     2160

tggaccatcc gagacaagtt tgcccggctc tcccagatgg ccaccatcct caatctggag     2220

cgggtgaccg agatcctcga ttactgggga cccaattccg gcccattgac gtggcgcctc     2280

acccctgctg aagtgcgcca ggtgctggcc ctgcggatag acttccgcag tgaagatatc     2340

aagaggctgc gcctgtag                                                   2358


<210>  4
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Asp Leu Asp Ser Pro Pro Lys Leu Ser Gly Val Gln Gln Pro 
1               5                   10                  15      


Ser Glu Gly Val Gly Gly Gly Arg Cys Ser Glu Ile Ser Ala Glu Leu 
            20                  25                  30          


Ile Arg Ser Pro Thr Glu Leu Gln Glu Leu Glu Ala Val Tyr Glu Arg 
        35                  40                  45              


Leu Cys Gly Glu Glu Lys Val Val Glu Arg Glu Leu Asp Ala Leu Leu 
    50                  55                  60                  


Glu Gln Gln Asn Thr Ile Glu Ser Lys Met Val Thr Leu His Arg Met 
65                  70                  75                  80  


Gly Pro Asn Leu Gln Leu Ile Glu Gly Asp Ala Lys Gln Leu Ala Gly 
                85                  90                  95      


Met Ile Thr Phe Thr Cys Asn Leu Ala Glu Asn Val Ser Ser Lys Val 
            100                 105                 110         


Arg Gln Leu Asp Leu Ala Lys Asn Arg Leu Tyr Gln Ala Ile Gln Arg 
        115                 120                 125             


Ala Asp Asp Ile Leu Asp Leu Lys Phe Cys Met Asp Gly Val Gln Thr 
    130                 135                 140                 


Ala Leu Arg Ser Glu Asp Tyr Glu Gln Ala Ala Ala His Ile His Arg 
145                 150                 155                 160 


Tyr Leu Cys Leu Asp Lys Ser Val Ile Glu Leu Ser Arg Gln Gly Lys 
                165                 170                 175     


Glu Gly Ser Met Ile Asp Ala Asn Leu Lys Leu Leu Gln Glu Ala Glu 
            180                 185                 190         


Gln Arg Leu Lys Ala Ile Val Ala Glu Lys Phe Ala Ile Ala Thr Lys 
        195                 200                 205             


Glu Gly Asp Leu Pro Gln Val Glu Arg Phe Phe Lys Ile Phe Pro Leu 
    210                 215                 220                 


Leu Gly Leu His Glu Glu Gly Leu Arg Lys Phe Ser Glu Tyr Leu Cys 
225                 230                 235                 240 


Lys Gln Val Ala Ser Lys Ala Glu Glu Asn Leu Leu Met Val Leu Gly 
                245                 250                 255     


Thr Asp Met Ser Asp Arg Arg Ala Ala Val Ile Phe Ala Asp Thr Leu 
            260                 265                 270         


Thr Leu Leu Phe Glu Gly Ile Ala Arg Ile Val Glu Thr His Gln Pro 
        275                 280                 285             


Ile Val Glu Thr Tyr Tyr Gly Pro Gly Arg Leu Tyr Thr Leu Ile Lys 
    290                 295                 300                 


Tyr Leu Gln Val Glu Cys Asp Arg Gln Val Glu Lys Val Val Asp Lys 
305                 310                 315                 320 


Phe Ile Lys Gln Arg Asp Tyr His Gln Gln Phe Arg His Val Gln Asn 
                325                 330                 335     


Asn Leu Met Arg Asn Ser Thr Thr Glu Lys Ile Glu Pro Arg Glu Leu 
            340                 345                 350         


Asp Pro Ile Leu Thr Glu Val Thr Leu Met Asn Ala Arg Ser Glu Leu 
        355                 360                 365             


Tyr Leu Arg Phe Leu Lys Lys Arg Ile Ser Ser Asp Phe Glu Val Gly 
    370                 375                 380                 


Asp Ser Met Ala Ser Glu Glu Val Lys Gln Glu His Gln Lys Cys Leu 
385                 390                 395                 400 


Asp Lys Leu Leu Asn Asn Cys Leu Leu Ser Cys Thr Met Gln Glu Leu 
                405                 410                 415     


Ile Gly Leu Tyr Val Thr Met Glu Glu Tyr Phe Met Arg Glu Thr Val 
            420                 425                 430         


Asn Lys Ala Val Ala Leu Asp Thr Tyr Glu Lys Gly Gln Leu Thr Ser 
        435                 440                 445             


Ser Met Val Asp Asp Val Phe Tyr Ile Val Lys Lys Cys Ile Gly Arg 
    450                 455                 460                 


Ala Leu Ser Ser Ser Ser Ile Asp Cys Leu Cys Ala Met Ile Asn Leu 
465                 470                 475                 480 


Ala Thr Thr Glu Leu Glu Ser Asp Phe Arg Asp Val Leu Cys Asn Lys 
                485                 490                 495     


Leu Arg Met Gly Phe Pro Ala Thr Thr Phe Gln Asp Ile Gln Arg Gly 
            500                 505                 510         


Val Thr Ser Ala Val Asn Ile Met His Ser Ser Leu Gln Gln Gly Lys 
        515                 520                 525             


Phe Asp Thr Lys Gly Ile Glu Ser Thr Asp Glu Ala Lys Met Ser Phe 
    530                 535                 540                 


Leu Val Thr Leu Asn Asn Val Glu Val Cys Ser Glu Asn Ile Ser Thr 
545                 550                 555                 560 


Leu Lys Lys Thr Leu Glu Ser Asp Cys Thr Lys Leu Phe Ser Gln Gly 
                565                 570                 575     


Ile Gly Gly Glu Gln Ala Gln Ala Lys Phe Asp Ser Cys Leu Ser Asp 
            580                 585                 590         


Leu Ala Ala Val Ser Asn Lys Phe Arg Asp Leu Leu Gln Glu Gly Leu 
        595                 600                 605             


Thr Glu Leu Asn Ser Thr Ala Ile Lys Pro Gln Val Gln Pro Trp Ile 
    610                 615                 620                 


Asn Ser Phe Phe Ser Val Ser His Asn Ile Glu Glu Glu Glu Phe Asn 
625                 630                 635                 640 


Asp Tyr Glu Ala Asn Asp Pro Trp Val Gln Gln Phe Ile Leu Asn Leu 
                645                 650                 655     


Glu Gln Gln Met Ala Glu Phe Lys Ala Ser Leu Ser Pro Val Ile Tyr 
            660                 665                 670         


Asp Ser Leu Thr Gly Leu Met Thr Ser Leu Val Ala Val Glu Leu Glu 
        675                 680                 685             


Lys Val Val Leu Lys Ser Thr Phe Asn Arg Leu Gly Gly Leu Gln Phe 
    690                 695                 700                 


Asp Lys Glu Leu Arg Ser Leu Ile Ala Tyr Leu Thr Thr Val Thr Thr 
705                 710                 715                 720 


Trp Thr Ile Arg Asp Lys Phe Ala Arg Leu Ser Gln Met Ala Thr Ile 
                725                 730                 735     


Leu Asn Leu Glu Arg Val Thr Glu Ile Leu Asp Tyr Trp Gly Pro Asn 
            740                 745                 750         


Ser Gly Pro Leu Thr Trp Arg Leu Thr Pro Ala Glu Val Arg Gln Val 
        755                 760                 765             


Leu Ala Leu Arg Ile Asp Phe Arg Ser Glu Asp Ile Lys Arg Leu Arg 
    770                 775                 780                 


Leu 
785 


<210>  5
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Ala Gly Thr Arg Cys Leu Leu Ala Leu Leu Leu Pro Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ala Gly Leu Val Pro Glu Leu Gly Arg Arg Lys 
            20                  25                  30          


Phe Ala Ala Ala Ser Ser Gly Arg Pro Ser Ser Gln Pro Ser Asp Glu 
        35                  40                  45              


Val Leu Ser Glu Phe Glu Leu Arg Leu Leu Ser Met Phe Gly Leu Lys 
    50                  55                  60                  


Gln Arg Pro Thr Pro Ser Arg Asp Ala Val Val Pro Pro Tyr Met Leu 
65                  70                  75                  80  


Asp Leu Tyr Arg Arg His Ser Gly Gln Pro Gly Ser Pro Ala Pro Asp 
                85                  90                  95      


His Arg Leu Glu Arg Ala Ala Ser Arg Ala Asn Thr Val Arg Ser Phe 
            100                 105                 110         


His His Glu Glu Ser Leu Glu Glu Leu Pro Glu Thr Ser Gly Lys Thr 
        115                 120                 125             


Thr Arg Arg Phe Phe Phe Asn Leu Ser Ser Ile Pro Thr Glu Glu Phe 
    130                 135                 140                 


Ile Thr Ser Ala Glu Leu Gln Val Phe Arg Glu Gln Met Gln Asp Ala 
145                 150                 155                 160 


Leu Gly Asn Asn Ser Ser Phe His His Arg Ile Asn Ile Tyr Glu Ile 
                165                 170                 175     


Ile Lys Pro Ala Thr Ala Asn Ser Lys Phe Pro Val Thr Arg Leu Leu 
            180                 185                 190         


Asp Thr Arg Leu Val Asn Gln Asn Ala Ser Arg Trp Glu Ser Phe Asp 
        195                 200                 205             


Val Thr Pro Ala Val Met Arg Trp Thr Ala Gln Gly His Ala Asn His 
    210                 215                 220                 


Gly Phe Val Val Glu Val Ala His Leu Glu Glu Lys Gln Gly Val Ser 
225                 230                 235                 240 


Lys Arg His Val Arg Ile Ser Arg Ser Leu His Gln Asp Glu His Ser 
                245                 250                 255     


Trp Ser Gln Ile Arg Pro Leu Leu Val Thr Phe Gly His Asp Gly Lys 
            260                 265                 270         


Gly His Pro Leu His Lys Arg Glu Lys Arg Gln Ala Lys His Lys Gln 
        275                 280                 285             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    290                 295                 300                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
305                 310                 315                 320 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                325                 330                 335     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            340                 345                 350         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        355                 360                 365             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    370                 375                 380                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
385                 390                 395     


<210>  6
<211>  1273
<212>  PRT
<213>  Coronaviridae

<400>  6

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  7
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody light chain

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  8
<211>  450
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody heavy chain

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  9
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody light chain

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  10
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody heavy chain

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  11
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  11
ttagatctgc ggccgcgtga gcagggtgca cttgctgctt ttgtgccgct ttaatgagtt       60

cacacagcag aatacctaaa tctgcacaga accttggtta acattttaag gtaggcaaac      120

gcaggcatac caacttgttc ctgttgccat tgcagtgact aaaggaggga tgtcacaggg      180

tattaattac agagcaggcc atatgctatt tttgtacagt aatcctttcc tttttttccc      240

catttttctt aaatcttaaa aataagactg aattctgata tcaagagtta aggtcccttc      300

aatagttcag ctggtagagc agaggactat agctacttcc tcagtaggag acgtccttag      360

gttgctggtt cgattccagc ttgaaggaga caagtacagt tttggctggg cacggtggtt      420

catggctgta atcacagcac tttgggaggt taaggcaggt ggatcacgag gtcaggagat      480

caagatcatc ctggccaatg tggtgaaact ctgtctccgg tgcgggtgcc agggcgtgcc      540

cttgggctcc ccgggcgcgt actccacgcg gccgcctcga gtt                        583


<210>  12
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  12
gctggtagag cagaggacta t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  13
tcgaaccagc aacctaagga c                                                 21


<210>  14
<211>  1003
<212>  DNA
<213>  Homo sapiens

<400>  14
agatcttcta gagtttaaac cgccgctcac agtacccgaa aggcgcattt ttcacaaact       60

gttgtagaaa gagttcatgg cggggtggcg gcgggaaaaa aaaaaaaaaa gctaacgccg      120

tggccggtgc gggagtcgag cccgcgacct tggtgttatc agcaccacgc tcttaccaac      180

tgagctaacc ggccgcctga cggcacagtg cccctggagc gtataaaagg gctccacgtt      240

cgcgcccgtc cacgagcgat tcctcgccaa gcccgcgcgc ctctggctgc cttccgcttt      300

gccccagccg cggggactcc ggggaggagc caccgcccca gcgctggccg ggtttctccc      360

gctcctccct gccaggctgt cctcgacaac ctctgggccg agtccaagag atcccgcaag      420

tcgctcctgc ccgcatgggg cttacagaac ctgaaaggcg cattttgaaa aagagttgca      480

gaaacagttc atggaagctt aagcttcgtt cagcttccct tgggccccct ggctgctcgg      540

gcccggatcg cggaccgggg cgtttccggg gatttctgaa gcggacgagg ggcagggcgg      600

gcgaaggcca ttcggctctc cttctggctc cagaatctcc caacccgcag gtgtgcagtg      660

tgaccagcgc gactcaccgc tctaatcgct ccgattttcc aaggccttgc tcagtagtcc      720

tgccaggcgg gctctgaggc tggaagggat tggggagttc ggtgagtgcg ccctgcctat      780

agcgcccagt ggaatcgcta gtacctgtct ctgtggcgca atcggtcaga gcgttcggct      840

attaaccgaa cggtgagtag ttcaagacca cccagggacg cctgttctag ctttttttaa      900

agcattcatg tattatcatc actagagaat ctccccctat tcttcccata gtcctaagtc      960

cgaaaggttg gttccaggcc agcggcgcgc cgctagcaga tct                       1003


<210>  15
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
tcaggcggcc ggttagc                                                      17


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
gctaacgccg tggccggtg                                                    19


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
tcgctagtac ctgtctctgt gg                                                22


<210>  18
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  18
cctgggtggt cttgaactac tc                                                22


<210>  19
<211>  324
<212>  DNA
<213>  Schizosaccharomyces pombe

<400>  19
ggatcctttt cgttcaatca agatatttta tcacattatt tcaaggttca atgaatcatt       60

cgaagaatag taacgaattc agatatatta aataaaggca cacataatct ctaaagatta      120

cagtttaatg gctctttcaa agtgtttagt aatatataca ctaaatttct aaaattcagt      180

agttatggcg aagtggccga gtggtctatg gcgctagctt caggtgaaag caattgctag      240

tctacgtatg tgggcgtggg ttcgaacccc accttcgtca atataatttt ttatatcatg      300

ttaatggaat tgagaaaaac tagt                                             324


<210>  20
<211>  299
<212>  DNA
<213>  Homo sapiens

<400>  20
gccgggcgcg gtggcgcgtg cctgtagtcc cagctactcg ggaggctgag gctggaggat       60

cgcttgagtc caggagttct gggctgtagt gcgctatgcc gatcgggtgt ccgcactaag      120

ttcggcatca atatggtgac ctcccgggag cgggggacca ccaggttgcc taaggagggg      180

tgaaccggcc caggtcggaa acggagcagg tcaaaactcc cgtgctgatc agtagtggga      240

tcgcgcctgt gaatagccac tgcactccag cctgggcaac atagcgagac cccgtctct       299


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gDNA

<400>  21
cggtggagat ttcggagcag                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  gDNA

<400>  22
tctgacagag ctgcaggagc                                                   20


<210>  23
<211>  151
<212>  DNA
<213>  artificial sequence

<220>
<223>  repair DNA


<220>
<221>  phosphorothioate bonds
<222>  (1)..(4)

<220>
<221>  phosphorothioate bonds
<222>  (148)..(151)

<400>  23
caggagcgcc tccgccaccg gagggtttgc gaggagggca ctgctcggaa atctccaccg       60

agcttattcg ctctccgaca gagctgcagg agcttgagtc tgtgtacgaa cgcctctgcg      120

gcgaggaggt ggggagctga tcttcctttt t                                     151


