﻿                         序列表

<110>  百奥泰生物制药股份有限公司

<120>  抗PD-1抗体的应用

<150>  PCT/CN2021/095291
<151>  2021-05-21

<160>  26

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Asn Tyr Tyr Met Tyr Trp 
1               5       

<210>  2
<211>  15
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
1               5                   10                  15  

<210>  3
<211>  12
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Ala Arg Asp Tyr Arg Leu Asp Met Gly Phe Glu Phe 
1               5                   10          

<210>  4
<211>  14
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  

<210>  5
<211>  6
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Leu Ala Ser Tyr Leu Glu 
1               5       

<210>  6
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Tyr Cys Gln His Ala Tyr Asp Leu Pro Leu Thr 
1               5                   10      

<210>  7
<211>  120
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Tyr Arg Leu Asp Met Gly Phe Glu Phe Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 

<210>  8
<211>  111
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ala Tyr 
                85                  90                  95      
Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     

<210>  9
<211>  447
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Arg Asp Tyr Arg Leu Asp Met Gly Phe Glu Phe Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         

<210>  10
<211>  218
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  10
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ala Tyr 
                85                  90                  95      
Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210>  11
<211>  5
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Thr Tyr Ala Met Ser 
1               5   

<210>  12
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  13
<211>  13
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr 
1               5                   10              

<210>  14
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  14
Arg Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ala 
1               5                   10      

<210>  15
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210>  16
<211>  11
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  16
Gln Thr Trp Ser Gly Trp Pro Asp Tyr Leu Thr 
1               5                   10      

<210>  17
<211>  122
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210>  18
<211>  109
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Trp Ser Gly Trp Pro Asp 
                85                  90                  95      
Tyr Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210>  19
<211>  452
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210>  20
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Thr Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Asp Thr Gly Val Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Tyr Ala Tyr Leu Val Asp Gly Trp Phe Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 
Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             
Ala 
    

<210>  21
<211>  216
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Trp Ser Gly Trp Pro Asp 
                85                  90                  95      
Tyr Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     

<210>  22
<211>  1341
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  22
caggtgcagc tggtgcagtc cggcgtggag gtgaagaagc ctggcgccag cgtgaaggtg        60
tcctgtaagg ccagcggcta caccttcacc aattactata tgtattgggt gcggcaggcc       120
cccggccagg gactggagtg gatgggaggc atcaatccca gcaacggcgg caccaacttc       180
aatgagaagt ttaagaaccg ggtgaccctg accaccgata gcagcaccac caccgcttac       240
atggagctga agagcctgca gtttgacgat accgctgtgt actattgcgc tgcccgggat       300
tacaggctgg acatgggctt cgagttctgg ggccagggca ccaccgtgac cgtgtccagc       360
gctagcacca agggcccttc cgtgttcccc ctggccccct gtagccggtc cacctctgag       420
agcaccgctg ctctgggctg tctggtgaag gattactttc ccgaaccggt gaccgtgtca       480
tggaactccg gggctctgac atccggtgtc cacacttttc ctgcagtgct gcagtcatcc       540
ggcctgtaca gcctgagctc tgtggtcaca gtcccaagtt catccctggg aaccaagaca       600
tatacttgca acgtggatca taaacccagc aatactaagg tcgacaaacg agtggagtct       660
aagtacggac caccttgccc accatgtcca gcacctgagt tcctgggagg accaagcgtg       720
ttcctgtttc ctccaaagcc taaagatacc ctgatgatca gtcggactcc cgaggtcacc       780
tgcgtggtcg tggacgtgtc ccaggaggac cctgaagtcc agttcaactg gtacgtggac       840
ggcgtcgaag tgcacaatgc taagacaaaa cctcgagagg aacagtttaa ctccacatac       900
cgtgtcgtga gcgtcctgac tgtgctgcat caggattggc tgaacggcaa ggagtataag       960
tgcaaagtga gcaataaggg actgccaagc tctatcgaga aaactatttc taaggctaaa      1020
ggacagccta gggaaccaca ggtgtacacc ctgcccccta gtcaggagga aatgactaag      1080
aaccaggtct cactgacctg tctggtgaaa gggttctatc cttcagatat tgcagtggag      1140
tgggaatcca atggtcagcc agagaacaat tacaagacaa ctccacccgt gctggacagc      1200
gatgggtctt tctttctgta ttctagactg accgtggaca aaagtcgctg gcaggagggt      1260
aatgtctttt cttgtagtgt gatgcacgaa gccctgcaca accactacac tcagaaaagc      1320
ctgtcactgt ccctgggtaa a                                                1341

<210>  23
<211>  654
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  23
gagatcgtgc tgacccagtc ccccgctacc ctgagcctgt cccccggaga gcgggctacc        60
ctgtcttgtc gggcctccaa gggcgtgagc accagcggat actcctatct gcactggtac       120
cagcagaagc ccggccaggc tcccaggctg ctgatctacc tggcttccta cctggagagc       180
ggcgtgcccg ctaggtttag cggcagcggc agcggaaccg atttcaccct gaccatcagc       240
tccctggagc ccgaggattt tgccgtgtac tactgccagc acgcttacga cctgcccctg       300
acctttggcg gcggcaccaa ggtggagatc aagcgtacgg tggctgcacc atctgtcttc       360
atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg       420
aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg       480
ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc       540
agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc       600
acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt             654

<210>  24
<211>  1356
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
gaggttcagt tggtagagtc cggcggaggg ttggtgcagc ctggggggtc gcttcgctta        60
agctgcgcgg cgtcagggtt ttcgtttgat acatatgcta tgagctgggt tcgacaggca       120
ccgggtaagg gtctggagtg ggtaagcgcc ataagcggtg acacaggagt gacaggttac       180
gcagatagcg tgaagggacg atttacgatc tctagagaca attcaaaaaa taccctatac       240
ttgcagatga attcgttgcg agcagaggat acggcggtat actattgtgc aagagaccgc       300
tatgcatatt tggttgatgg gtggttcgat tactggggac aagggactct cgttaccgtt       360
tctagcgcat cgacaaaagg accgagtgtt ttcccgctcg cgcccagttc gaagtccaca       420
tctggtggta cagccgcact tggttgtctg gttaaagact acttccccga accagtcact       480
gtcagttgga atagtggtgc actcactagc ggagtccata cctttcctgc agtattgcag       540
tcgtccgggt tgtactccct gtcctcggtt gtaacggttc cgtctagtag tttgggaaca       600
caaacttaca tttgtaatgt caatcacaaa ccaagtaaca caaaggtaga caaaaaggtt       660
gaaccgaagt cctgtgacaa aacgcataca tgccctccgt gccccgctcc tgagcttctc       720
ggcgggccgt ccgtgttcct ttttccaccc aaaccaaaag atacgttaat gatcagccgg       780
acaccagaag taacatgcgt agtggtagac gtgagccacg aagatccgga agtcaagttt       840
aactggtacg tcgacggggt tgaggtgcac aatgctaaga cgaaaccacg tgaagaacag       900
tataactcca cctaccgtgt ggtatcggta ctgacggttt tacatcagga ttggctgaac       960
ggaaaggagt ataaatgcaa agtcagtaac aaagcgcttc cagctcccat tgagaagact      1020
atttccaagg ctaaaggaca gccgcgagag cctcaggtgt atacgctgcc accatcccga      1080
gacgagctta ctaagaatca agttagcctg acatgcctcg tgaaaggttt ttatccaagc      1140
gatatcgcgg ttgagtggga gtcgaacggc cagccagaga ataattacaa aacaacgcct      1200
ccggttcttg attcggatgg ctcgttcttt ctgtattcga aattgactgt tgataaaagt      1260
cgttggcagc aggggaatgt cttcagttgc agcgtaatgc atgaagccct acacaaccac      1320
tacacacaaa agagtttatc gttatctcca ggtaag                                1356

<210>  25
<211>  1347
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  25
gaggtgcagc tggtggagag cggcggcgga ctggtgcagc ctggaggaag cctgcggctg        60
tcctgcgctg ctagcggctt cagctttgac acctacgcca tgagctgggt gcggcaggcc       120
cctggaaagg gcctggagtg ggtgtccgcc atctccggcg acaccggcgt gaccggatat       180
gctgactccg tgaagggcag gtttaccatc agccgggata actccaagaa caccctgtat       240
ctgcagatga acagcctgag ggccgaggat accgccgtgt attactgcgc tagggacagg       300
tacgcctatc tggtggacgg ctggttcgac tactggggcc agggcaccct ggtgaccgtg       360
agctccgcca gcaccaaggg cccttccgtg tttcccctgg ctccctgctc caggtccacc       420
agcgagtcca ccgccgccct gggatgtctg gtgaaggatt atttccctga gcccgtgacc       480
gtgtcctgga atagcggcgc tctgacctcc ggcgtgcaca ccttccctgc cgtgctgcag       540
tcctccggcc tgtattccct gagctccgtg gtgaccgtgc ccagcagctc cctgggcacc       600
aagacctaca cctgcaacgt ggatcacaag cctagcaaca ccaaggtgga caagagggtg       660
gagagcaagt acggcccccc ctgcccccca tgtcctgctc ctgagttcct gggcggcccc       720
agcgtgttcc tgttcccccc taagcccaag gataccctga tgatcagcag gacccccgag       780
gtgacctgcg tggtggtgga cgtgagccag gaggatcccg aggtgcagtt taactggtac       840
gtggatggcg tggaggtgca caacgccaag accaagcccc gggaggagca gtttaacagc       900
acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa tggcaaggag       960
tataagtgca aggtgagcaa caagggcctg cccagcagca tcgagaagac catcagcaag      1020
gccaagggcc agccccggga gcctcaggtt tataccctgc ccccttccca ggaggagatg      1080
accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctacccctc cgatatcgcc      1140
gtggagtggg agtccaacgg ccagcccgag aataattaca agaccacccc tcctgtgctg      1200
gattccgatg gctccttctt cctgtactcc cggctgaccg tggataagag caggtggcag      1260
gagggcaacg tgtttagctg cagcgtgatg cacgaggctc tgcacaacca ctacacccag      1320
aagagcctga gcctgtccct gggcgct                                          1347

<210>  26
<211>  648
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  26
gatattcaaa tgacgcagtc cccgagctct ctgtcggcgt ctgtcggcga ccgtgtaacc        60
atcacttgcc gggcgtctca aggaatcagt tcctacctcg cctggtacca gcaaaaaccg       120
ggtaaagctc ctaagttgct tatttatgcc gcctcttcct tacagtctgg cgtaccctcg       180
cgattctctg gaagcggatc cggcacagac tttactctaa caatcagttc tctgcaaccg       240
gaggacttcg caacctacta ttgtcagacc tggtcgggat ggcctgacta tctcacgttt       300
ggtcaaggaa ctaaggtaga aataaaaagg acagtcgcag caccttcggt gtttatcttt       360
cctccgtcgg acgaacagtt aaagagtgga accgctagcg tggtctgtct tttgaataat       420
ttctacccga gggaagctaa agtccagtgg aaagtggaca acgcactcca atcgggtaat       480
tcacaagagt cagtgaccga acaggactct aaggactcaa catattccct ctcctcgact       540
ttgactttat ctaaagcaga ttatgagaaa cacaaggtgt atgcctgcga ggtgactcat       600
caaggtctct ctagccctgt taccaaaagt tttaacaggg gagagtgt                    648

