                         SEQUENCE LISTING

<110>  The University of Hong Kong
 
<120>  COMPOSITIONS AND METHODS OF TARGETING THE PAX6 SIGNALING PATHWAY 
       TO REDUCE FORMATION OF AMYLOID BETA PLAQUES AND NEUROFIBRILLARY 
       TANGLES

<130>  F22W2103

<150>  US 63/191,925
<151>  2021-05-21

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  2500
<212>  DNA
<213>  Homo sapiens

<400>  1
agcataggaa tctgagaatt gctctcacac accaacccag caacatccgt ggagaaaact       60

ctcaccagca actcctttaa aacaccgtca tttcaaacca ttgtggtctt caagcaacaa      120

cagcagcaca aaaaacccca accaaacaaa actcttgaca gaagctgtga caaccagaaa      180

ggatgcctca taaaggggga agactttaac taggggcgcg cagatgtgtg aggcctttta      240

ttgtgagagt ggacagacat ccgagatttc agagccccat attcgagccc cgtggaatcc      300

cgcggccccc agccagagcc agcatgcaga acagtcacag cggagtgaat cagctcggtg      360

gtgtctttgt caacgggcgg ccactgccgg actccacccg gcagaagatt gtagagctag      420

ctcacagcgg ggcccggccg tgcgacattt cccgaattct gcaggtgtcc aacggatgtg      480

tgagtaaaat tctgggcagg tattacgaga ctggctccat cagacccagg gcaatcggtg      540

gtagtaaacc gagagtagcg actccagaag ttgtaagcaa aatagcccag tataagcggg      600

agtgcccgtc catctttgct tgggaaatcc gagacagatt actgtccgag ggggtctgta      660

ccaacgataa cataccaagc gtgtcatcaa taaacagagt tcttcgcaac ctggctagcg      720

aaaagcaaca gatgggcgca gacggcatgt atgataaact aaggatgttg aacgggcaga      780

ccggaagctg gggcacccgc cctggttggt atccggggac ttcggtgcca gggcaaccta      840

cgcaagatgg ctgccagcaa caggaaggag ggggagagaa taccaactcc atcagttcca      900

acggagaaga ttcagatgag gctcaaatgc gacttcagct gaagcggaag ctgcaaagaa      960

atagaacatc ctttacccaa gagcaaattg aggccctgga gaaagagttt gagagaaccc     1020

attatccaga tgtgtttgcc cgagaaagac tagcagccaa aatagatcta cctgaagcaa     1080

gaatacaggt atggttttct aatcgaaggg ccaaatggag aagagaagaa aaactgagga     1140

atcagagaag acaggccagc aacacaccta gtcatattcc tatcagcagt agtttcagca     1200

ccagtgtcta ccaaccaatt ccacaaccca ccacaccggt ttcctccttc acatctggct     1260

ccatgttggg ccgaacagac acagccctca caaacaccta cagcgctctg ccgcctatgc     1320

ccagcttcac catggcaaat aacctgccta tgcaaccccc agtccccagc cagacctcct     1380

catactcctg catgctgccc accagccctt cggtgaatgg gcggagttat gatacctaca     1440

cccccccaca tatgcagaca cacatgaaca gtcagccaat gggcacctcg ggcaccactt     1500

caacaggact catttcccct ggtgtgtcag ttccagttca agttcccgga agtgaacctg     1560

atatgtctca atactggcca agattacagt aaaaaaaaaa aaaaaaaaaa aaaggaaagg     1620

aaatattgtg ttaattcagt cagtgactat ggggacacaa cagttgagct ttcaggaaag     1680

aaagaaaaat ggctgttaga gccgcttcag ttctacaatt gtgtcctgta ttgtaccact     1740

ggggaaggaa tggacttgaa acaaggacct ttgtatacag aaggcacgat atcagttgga     1800

acaaatcttc attttggtat ccaaactttt attcattttg gtgtattatt tgtaaatggg     1860

catttgtatg ttataatgaa aaaaagaaca atgtagactg gatggatgtt tgatctgtgt     1920

tggtcatgaa gttgtttttt ttttttttaa aaagaaaacc atgatcaaca agctttgcca     1980

cgaatttaag agttttatca agatatatcg aatacttcta cccatctgtt catagtttat     2040

ggactgatgt tccaagtttg tatcattcct ttgcatataa ttaaacctgg aacaacatgc     2100

actagattta tgtcagaaat atctgttggt tttccaaagg ttgttaacag atgaagttta     2160

tgtgcaaaaa agggtaagat ataaattcaa ggaagaaaaa aagttgatag ctaaaaggta     2220

gagtgtgtct tcgatataat ccaatttgtt ttatgtcaaa atgtaagtat ttgtcttccc     2280

tagaaatcct cagaatgatt tctataataa agttaatttc atttatattt gacaagaata     2340

tagatgtttt atacacattt tcatgcaatc atacgtttct tttttggcca gcaaaagtta     2400

attgttctta gatatagttg tattactgtt cacggtccaa tcattttgtg catctagagt     2460

tcattcctaa tcaattaaaa gtgcttgcaa gagttttaaa                           2500


<210>  2
<211>  6922
<212>  DNA
<213>  Homo sapiens

<400>  2
accctctttt cttatcattg acatttaaac tctggggcag gtcctcgcgt agaacgcggc       60

tgtcagatct gccacttccc ctgccgagcg gcggtgagaa gtgtgggaac cggcgctgcc      120

aggctcacct gcctccccgc cctccgctcc caggaatctg agaattgctc tcacacacca      180

acccagcaac atccgtggag aaaactctca ccagcaactc ctttaaaaca ccgtcatttc      240

aaaccattgt ggtcttcaag caacaacagc agcacaaaaa accccaacca aacaaaactc      300

ttgacagaag ctgtgacaac cagaaaggat gcctcataaa gggggaagac tttaactagg      360

ggcgcgcaga tgtgtgaggc cttttattgt gagagtggac agacatccga gatttcagag      420

ccccatattc gagccccgtg gaatcccgcg gcccccagcc agagccagca tgcagaacag      480

tcacagcgga gtgaatcagc tcggtggtgt ctttgtcaac gggcggccac tgccggactc      540

cacccggcag aagattgtag agctagctca cagcggggcc cggccgtgcg acatttcccg      600

aattctgcag acccatgcag atgcaaaagt ccaagtgctg gacaatcaaa acgtgtccaa      660

cggatgtgtg agtaaaattc tgggcaggta ttacgagact ggctccatca gacccagggc      720

aatcggtggt agtaaaccga gagtagcgac tccagaagtt gtaagcaaaa tagcccagta      780

taagcgggag tgcccgtcca tctttgcttg ggaaatccga gacagattac tgtccgaggg      840

ggtctgtacc aacgataaca taccaagcgt gtcatcaata aacagagttc ttcgcaacct      900

ggctagcgaa aagcaacaga tgggcgcaga cggcatgtat gataaactaa ggatgttgaa      960

cgggcagacc ggaagctggg gcacccgccc tggttggtat ccggggactt cggtgccagg     1020

gcaacctacg caagatggct gccagcaaca ggaaggaggg ggagagaata ccaactccat     1080

cagttccaac ggagaagatt cagatgaggc tcaaatgcga cttcagctga agcggaagct     1140

gcaaagaaat agaacatcct ttacccaaga gcaaattgag gccctggaga aagagtttga     1200

gagaacccat tatccagatg tgtttgcccg agaaagacta gcagccaaaa tagatctacc     1260

tgaagcaaga atacaggtat ggttttctaa tcgaagggcc aaatggagaa gagaagaaaa     1320

actgaggaat cagagaagac aggccagcaa cacacctagt catattccta tcagcagtag     1380

tttcagcacc agtgtctacc aaccaattcc acaacccacc acaccggttt cctccttcac     1440

atctggctcc atgttgggcc gaacagacac agccctcaca aacacctaca gcgctctgcc     1500

gcctatgccc agcttcacca tggcaaataa cctgcctatg caacccccag tccccagcca     1560

gacctcctca tactcctgca tgctgcccac cagcccttcg gtgaatgggc ggagttatga     1620

tacctacacc cccccacata tgcagacaca catgaacagt cagccaatgg gcacctcggg     1680

caccacttca acaggactca tttcccctgg tgtgtcagtt ccagttcaag ttcccggaag     1740

tgaacctgat atgtctcaat actggccaag attacagtaa aaaaaaaaaa aaaaaaaaaa     1800

aggaaaggaa atattgtgtt aattcagtca gtgactatgg ggacacaaca gttgagcttt     1860

caggaaagaa agaaaaatgg ctgttagagc cgcttcagtt ctacaattgt gtcctgtatt     1920

gtaccactgg ggaaggaatg gacttgaaac aaggaccttt gtatacagaa ggcacgatat     1980

cagttggaac aaatcttcat tttggtatcc aaacttttat tcattttggt gtattatttg     2040

taaatgggca tttgtatgtt ataatgaaaa aaagaacaat gtagactgga tggatgtttg     2100

atctgtgttg gtcatgaagt tgtttttttt ttttttaaaa agaaaaccat gatcaacaag     2160

ctttgccacg aatttaagag ttttatcaag atatatcgaa tacttctacc catctgttca     2220

tagtttatgg actgatgttc caagtttgta tcattccttt gcatataatt aaacctggaa     2280

caacatgcac tagatttatg tcagaaatat ctgttggttt tccaaaggtt gttaacagat     2340

gaagtttatg tgcaaaaaag ggtaagatat aaattcaagg aagaaaaaaa gttgatagct     2400

aaaaggtaga gtgtgtcttc gatataatcc aatttgtttt atgtcaaaat gtaagtattt     2460

gtcttcccta gaaatcctca gaatgatttc tataataaag ttaatttcat ttatatttga     2520

caagaatata gatgttttat acacattttc atgcaatcat acgtttcttt tttggccagc     2580

aaaagttaat tgttcttaga tatagttgta ttactgttca cggtccaatc attttgtgca     2640

tctagagttc attcctaatc aattaaaagt gcttgcaaga gttttaaact taagtgtttt     2700

gaagttgttc acaactacat atcaaaatta accattgttg attgtaaaaa accatgccaa     2760

agcctttgta tttcctttat tatacagttt tctttttaac cttatagtgt ggtgttacaa     2820

attttatttc catgttagat caacattcta aaccaatggt tactttcaca cacactctgt     2880

tttacatcct gatgatcctt aaaaaataat ccttatagat accataaatc aaaaacgtgt     2940

tagaaaaaaa ttccacttac agcagggtgt agatctgtgc ccatttatac ccacaacata     3000

tatacaaaat ggtaacattt cccagttagc catttaattc taaagctcaa agtctagaaa     3060

taatttaaaa atgcaacaag cgattagcta ggaattgttt tttgaattag gactggcatt     3120

ttcaatctgg gcagatttcc attgtcagcc tatttcaaca atgatttcac tgaagtatat     3180

tcaaaagtag atttcttaaa ggagactttc tgaaagctgt tgcctttttc aaataggccc     3240

tctccctttt ctgtctccct cccctttgca caagaggcat catttcccat tgaaccacta     3300

cagctgttcc catttgaatc ttgctttctg tgcggttgtg gatggttgga gggtggaggg     3360

gggatgttgc atgtcaagga ataatgagca cagacacatc aacagacaac aacaaagcag     3420

actgtgactg gccggtggga attaaaggcc ttcagtcatt ggcagcttaa gccaaacatt     3480

cccaaatcta tgaagcaggg cccattgttg gtcagttgtt atttgcaatg aagcacagtt     3540

ctgatcatgt ttaaagtgga ggcacgcagg gcaggagtgc ttgagcccaa gcaaaggatg     3600

gaaaaaaata agcctttgtt gggtaaaaaa ggactgtctg agactttcat ttgttctgtg     3660

caacatataa gtcaatacag ataagtcttc ctctgcaaac ttcactaaaa agcctggggg     3720

ttctggcagt ctagattaaa atgcttgcac atgcagaaac ctctggggac aaagacacac     3780

ttccactgaa ttatactctg ctttaaaaaa atccccaaaa gcaaatgatc agaaatgtag     3840

aaattaatgg aaggatttaa acatgacctt ctcgttcaat atctactgtt ttttagttaa     3900

ggaattactt gtgaacagat aattgagatt cattgctccg gcatgaaata tactaataat     3960

tttattccac cagagttgct gcacatttgg agacaccttc ctaagttgca gtttttgtat     4020

gtgtgcatgt agttttgttc agtgtcagcc tgcactgcac agcagcacat ttctgcaggg     4080

gagtgagcac acatacgcac tgttggtaca attgccggtg cagacatttc tacctcctga     4140

cattttgcag cctacattcc ctgagggctg tgtgctgagg gaactgtcag agaagggcta     4200

tgtgggagtg catgccacag ctgctggctg gcttacttct tccttctcgc tggctgtaat     4260

ttccaccacg gtcaggcagc cagttccggc ccacggttct gttgtgtaga cagcagagac     4320

tttggagacc cggatgtcgc acgccaggtg caagaggtgg gaatgggaga aaaggagtga     4380

cgtgggagcg gagggtctgt atgtgtgcac ttgggcacgt atatgtgtgc tctgaaggtc     4440

aggattgcca gggcaaagta gcacagtctg gtatagtctg aagaagcggc tgctcagctg     4500

cagaagccct ctggtccggc aggatgggaa cggctgcctt gccttctgcc cacaccctag     4560

ggacatgagc tgtccttcca aacagagctc caggcactct cttggggaca gcatggcagg     4620

ctctgtgtgg tagcagtgcc tgggagttgg ccttttactc attgttgaaa taatttttgt     4680

ttattattta tttaacgata catatattta tatatttatc aatggggtat ctgcagggat     4740

gttttgacac catcttccag gatggagatt atttgtgaag acttcagtag aatcccagga     4800

ctaaacgtct aaattttttc tccaaacttg actgacttgg gaaaaccagg tgaatagaat     4860

aagagctgaa tgttttaagt aataaacgtt caaactgctc taagtaaaaa aatgcatttt     4920

actgcaatga atttctagaa tatttttccc ccaaagctat gcctcctaac ccttaaatgg     4980

tgaacaactg gtttcttgct acagctcact gccatttctt cttactatca tcactaggtt     5040

tcctaagatt cactcataca gtattatttg aagattcagc tttgttctgt gaatgtcatc     5100

ttaggattgt gtctatattc ttttgcttat ttctttttac tctgggcctc tcatactagt     5160

aagattttaa aaagcctttt cttctctgta tgtttggctc accaaggcga aatatatatt     5220

cttctctttt tcatttctca agaataaacc tcatctgctt ttttgttttt ctgtgttttg     5280

gcttggtact gaatgactca actgctcggt tttaaagttc aaagtgtaag tacttagggt     5340

tagtactgct tatttcaata atgttgacgg tgactatctt tggaaagcag taacatgctg     5400

tcttagaaat gacattaata atgggcttaa acaaatgaat aggggggtcc ccccactctc     5460

cttttgtatg cctatgtgtg tctgatttgt taaaagatgg acagggaatt gattgcagag     5520

tgtcgcttcc ttctaaagta gttttatttt gtctactgtt agtatttaaa gatcctggag     5580

gtggacataa ggaataaatg gaagagaaaa gtagatattg tatggtggct actaaaagga     5640

aattcaaaaa gtcttagaac ccgagcacct gagcaaactg cagtagtcaa aatatttatc     5700

tcatgttaaa gaaaggcaaa tctagtgtaa gaaatgagta ccatataggg ttttgaagtt     5760

catatactag aaacacttaa aagatatcat ttcagatatt acgtttggca ttgttcttaa     5820

gtatttatat ctttgagtca agctgataat taaaaaaaat ctgttaatgg agtgtatatt     5880

tcataatgta tcaaaatggt gtctatacct aaggtagcat tattgaagag agatatgttt     5940

atgtagtaag ttattaacat aatgagtaac aaataatgtt tccagaagaa aggaaaacac     6000

attttcagag tgcgttttta tcagaggaag acaaaaatac acacccctct ccagtagctt     6060

atttttacaa agccggccca gtgaattaga aaaacaaagc acttggatat gatttttgga     6120

aagcccaggt acacttatta ttcaaaatgc acttttactg agtttgaaaa gtttctttta     6180

tatttaaaat aagggttcaa atatgcatat tcaattttta tagtagttat ctatttgcaa     6240

agcatatatt aactagtaat tggctgttaa ttttatagac atggtagcca gggaagtata     6300

tcaatgacct attaagtatt ttgacaagca atttacatat ctgatgacct cgtatctctt     6360

tttcagcaag tcaaatgcta tgtaattgtt ccattgtgtg ttgtataaaa tgaatcaaca     6420

cggtaagaaa aaggttagag ttattaaaat aataaactga ctaaaatact catttgaatt     6480

tattcagaat gttcataatg ctttcaaagg acatagcaga gcttttgtgg agtatccgca     6540

caacattatt tattatctat ggactaaatc aattttttga agttgcttta aaatttaaaa     6600

gcacctttgc ttaatataaa gccctttaat tttaactgac agatcaattc tgaaacttta     6660

ttttgaaaag aaaatgggga agaatctgtg tctttagaat taaaagaaat gaaaaaaata     6720

aacccgacat tctaaaaaaa tagaataaga aacctgattt ttagtactaa tgaaatagcg     6780

ggtgacaaaa tagttgtctt tttgattttg atcacaaaaa ataaactggt agtgacagga     6840

tatgatggag agatttgaca tcctggcaaa tcactgtcat tgattcaatt attctaattc     6900

tgaataaaag ctgtatacag ta                                              6922


<210>  3
<211>  6863
<212>  DNA
<213>  Homo sapiens

<400>  3
gcacttagtc aacaaatggc acgtgggaga agttggtgag tgtttggtga ggactcttca       60

gggcttttca caagaaccct ctgtacacaa agaatctgag aattgctctc acacaccaac      120

ccagcaacat ccgtggagaa aactctcacc agcaactcct ttaaaacacc gtcatttcaa      180

accattgtgg tcttcaagca acaacagcag cacaaaaaac cccaaccaaa caaaactctt      240

gacagaagct gtgacaacca gaaaggatgc ctcataaagg gggaagactt taactagggg      300

cgcgcagatg tgtgaggcct tttattgtga gagtggacag acatccgaga tttcagagcc      360

ccatattcga gccccgtgga atcccgcggc ccccagccag agccagcatg cagaacagtc      420

acagcggagt gaatcagctc ggtggtgtct ttgtcaacgg gcggccactg ccggactcca      480

cccggcagaa gattgtagag ctagctcaca gcggggcccg gccgtgcgac atttcccgaa      540

ttctgcagac ccatgcagat gcaaaagtcc aagtgctgga caatcaaaac gtgtccaacg      600

gatgtgtgag taaaattctg ggcaggtatt acgagactgg ctccatcaga cccagggcaa      660

tcggtggtag taaaccgaga gtagcgactc cagaagttgt aagcaaaata gcccagtata      720

agcgggagtg cccgtccatc tttgcttggg aaatccgaga cagattactg tccgaggggg      780

tctgtaccaa cgataacata ccaagcgtgt catcaataaa cagagttctt cgcaacctgg      840

ctagcgaaaa gcaacagatg ggcgcagacg gcatgtatga taaactaagg atgttgaacg      900

ggcagaccgg aagctggggc acccgccctg gttggtatcc ggggacttcg gtgccagggc      960

aacctacgca agatggctgc cagcaacagg aaggaggggg agagaatacc aactccatca     1020

gttccaacgg agaagattca gatgaggctc aaatgcgact tcagctgaag cggaagctgc     1080

aaagaaatag aacatccttt acccaagagc aaattgaggc cctggagaaa gagtttgaga     1140

gaacccatta tccagatgtg tttgcccgag aaagactagc agccaaaata gatctacctg     1200

aagcaagaat acaggtatgg ttttctaatc gaagggccaa atggagaaga gaagaaaaac     1260

tgaggaatca gagaagacag gccagcaaca cacctagtca tattcctatc agcagtagtt     1320

tcagcaccag tgtctaccaa ccaattccac aacccaccac accggtttcc tccttcacat     1380

ctggctccat gttgggccga acagacacag ccctcacaaa cacctacagc gctctgccgc     1440

ctatgcccag cttcaccatg gcaaataacc tgcctatgca acccccagtc cccagccaga     1500

cctcctcata ctcctgcatg ctgcccacca gcccttcggt gaatgggcgg agttatgata     1560

cctacacccc cccacatatg cagacacaca tgaacagtca gccaatgggc acctcgggca     1620

ccacttcaac aggactcatt tcccctggtg tgtcagttcc agttcaagtt cccggaagtg     1680

aacctgatat gtctcaatac tggccaagat tacagtaaaa aaaaaaaaaa aaaaaaaaag     1740

gaaaggaaat attgtgttaa ttcagtcagt gactatgggg acacaacagt tgagctttca     1800

ggaaagaaag aaaaatggct gttagagccg cttcagttct acaattgtgt cctgtattgt     1860

accactgggg aaggaatgga cttgaaacaa ggacctttgt atacagaagg cacgatatca     1920

gttggaacaa atcttcattt tggtatccaa acttttattc attttggtgt attatttgta     1980

aatgggcatt tgtatgttat aatgaaaaaa agaacaatgt agactggatg gatgtttgat     2040

ctgtgttggt catgaagttg tttttttttt ttttaaaaag aaaaccatga tcaacaagct     2100

ttgccacgaa tttaagagtt ttatcaagat atatcgaata cttctaccca tctgttcata     2160

gtttatggac tgatgttcca agtttgtatc attcctttgc atataattaa acctggaaca     2220

acatgcacta gatttatgtc agaaatatct gttggttttc caaaggttgt taacagatga     2280

agtttatgtg caaaaaaggg taagatataa attcaaggaa gaaaaaaagt tgatagctaa     2340

aaggtagagt gtgtcttcga tataatccaa tttgttttat gtcaaaatgt aagtatttgt     2400

cttccctaga aatcctcaga atgatttcta taataaagtt aatttcattt atatttgaca     2460

agaatataga tgttttatac acattttcat gcaatcatac gtttcttttt tggccagcaa     2520

aagttaattg ttcttagata tagttgtatt actgttcacg gtccaatcat tttgtgcatc     2580

tagagttcat tcctaatcaa ttaaaagtgc ttgcaagagt tttaaactta agtgttttga     2640

agttgttcac aactacatat caaaattaac cattgttgat tgtaaaaaac catgccaaag     2700

cctttgtatt tcctttatta tacagttttc tttttaacct tatagtgtgg tgttacaaat     2760

tttatttcca tgttagatca acattctaaa ccaatggtta ctttcacaca cactctgttt     2820

tacatcctga tgatccttaa aaaataatcc ttatagatac cataaatcaa aaacgtgtta     2880

gaaaaaaatt ccacttacag cagggtgtag atctgtgccc atttataccc acaacatata     2940

tacaaaatgg taacatttcc cagttagcca tttaattcta aagctcaaag tctagaaata     3000

atttaaaaat gcaacaagcg attagctagg aattgttttt tgaattagga ctggcatttt     3060

caatctgggc agatttccat tgtcagccta tttcaacaat gatttcactg aagtatattc     3120

aaaagtagat ttcttaaagg agactttctg aaagctgttg cctttttcaa ataggccctc     3180

tcccttttct gtctccctcc cctttgcaca agaggcatca tttcccattg aaccactaca     3240

gctgttccca tttgaatctt gctttctgtg cggttgtgga tggttggagg gtggaggggg     3300

gatgttgcat gtcaaggaat aatgagcaca gacacatcaa cagacaacaa caaagcagac     3360

tgtgactggc cggtgggaat taaaggcctt cagtcattgg cagcttaagc caaacattcc     3420

caaatctatg aagcagggcc cattgttggt cagttgttat ttgcaatgaa gcacagttct     3480

gatcatgttt aaagtggagg cacgcagggc aggagtgctt gagcccaagc aaaggatgga     3540

aaaaaataag cctttgttgg gtaaaaaagg actgtctgag actttcattt gttctgtgca     3600

acatataagt caatacagat aagtcttcct ctgcaaactt cactaaaaag cctgggggtt     3660

ctggcagtct agattaaaat gcttgcacat gcagaaacct ctggggacaa agacacactt     3720

ccactgaatt atactctgct ttaaaaaaat ccccaaaagc aaatgatcag aaatgtagaa     3780

attaatggaa ggatttaaac atgaccttct cgttcaatat ctactgtttt ttagttaagg     3840

aattacttgt gaacagataa ttgagattca ttgctccggc atgaaatata ctaataattt     3900

tattccacca gagttgctgc acatttggag acaccttcct aagttgcagt ttttgtatgt     3960

gtgcatgtag ttttgttcag tgtcagcctg cactgcacag cagcacattt ctgcagggga     4020

gtgagcacac atacgcactg ttggtacaat tgccggtgca gacatttcta cctcctgaca     4080

ttttgcagcc tacattccct gagggctgtg tgctgaggga actgtcagag aagggctatg     4140

tgggagtgca tgccacagct gctggctggc ttacttcttc cttctcgctg gctgtaattt     4200

ccaccacggt caggcagcca gttccggccc acggttctgt tgtgtagaca gcagagactt     4260

tggagacccg gatgtcgcac gccaggtgca agaggtggga atgggagaaa aggagtgacg     4320

tgggagcgga gggtctgtat gtgtgcactt gggcacgtat atgtgtgctc tgaaggtcag     4380

gattgccagg gcaaagtagc acagtctggt atagtctgaa gaagcggctg ctcagctgca     4440

gaagccctct ggtccggcag gatgggaacg gctgccttgc cttctgccca caccctaggg     4500

acatgagctg tccttccaaa cagagctcca ggcactctct tggggacagc atggcaggct     4560

ctgtgtggta gcagtgcctg ggagttggcc ttttactcat tgttgaaata atttttgttt     4620

attatttatt taacgataca tatatttata tatttatcaa tggggtatct gcagggatgt     4680

tttgacacca tcttccagga tggagattat ttgtgaagac ttcagtagaa tcccaggact     4740

aaacgtctaa attttttctc caaacttgac tgacttggga aaaccaggtg aatagaataa     4800

gagctgaatg ttttaagtaa taaacgttca aactgctcta agtaaaaaaa tgcattttac     4860

tgcaatgaat ttctagaata tttttccccc aaagctatgc ctcctaaccc ttaaatggtg     4920

aacaactggt ttcttgctac agctcactgc catttcttct tactatcatc actaggtttc     4980

ctaagattca ctcatacagt attatttgaa gattcagctt tgttctgtga atgtcatctt     5040

aggattgtgt ctatattctt ttgcttattt ctttttactc tgggcctctc atactagtaa     5100

gattttaaaa agccttttct tctctgtatg tttggctcac caaggcgaaa tatatattct     5160

tctctttttc atttctcaag aataaacctc atctgctttt ttgtttttct gtgttttggc     5220

ttggtactga atgactcaac tgctcggttt taaagttcaa agtgtaagta cttagggtta     5280

gtactgctta tttcaataat gttgacggtg actatctttg gaaagcagta acatgctgtc     5340

ttagaaatga cattaataat gggcttaaac aaatgaatag gggggtcccc ccactctcct     5400

tttgtatgcc tatgtgtgtc tgatttgtta aaagatggac agggaattga ttgcagagtg     5460

tcgcttcctt ctaaagtagt tttattttgt ctactgttag tatttaaaga tcctggaggt     5520

ggacataagg aataaatgga agagaaaagt agatattgta tggtggctac taaaaggaaa     5580

ttcaaaaagt cttagaaccc gagcacctga gcaaactgca gtagtcaaaa tatttatctc     5640

atgttaaaga aaggcaaatc tagtgtaaga aatgagtacc atatagggtt ttgaagttca     5700

tatactagaa acacttaaaa gatatcattt cagatattac gtttggcatt gttcttaagt     5760

atttatatct ttgagtcaag ctgataatta aaaaaaatct gttaatggag tgtatatttc     5820

ataatgtatc aaaatggtgt ctatacctaa ggtagcatta ttgaagagag atatgtttat     5880

gtagtaagtt attaacataa tgagtaacaa ataatgtttc cagaagaaag gaaaacacat     5940

tttcagagtg cgtttttatc agaggaagac aaaaatacac acccctctcc agtagcttat     6000

ttttacaaag ccggcccagt gaattagaaa aacaaagcac ttggatatga tttttggaaa     6060

gcccaggtac acttattatt caaaatgcac ttttactgag tttgaaaagt ttcttttata     6120

tttaaaataa gggttcaaat atgcatattc aatttttata gtagttatct atttgcaaag     6180

catatattaa ctagtaattg gctgttaatt ttatagacat ggtagccagg gaagtatatc     6240

aatgacctat taagtatttt gacaagcaat ttacatatct gatgacctcg tatctctttt     6300

tcagcaagtc aaatgctatg taattgttcc attgtgtgtt gtataaaatg aatcaacacg     6360

gtaagaaaaa ggttagagtt attaaaataa taaactgact aaaatactca tttgaattta     6420

ttcagaatgt tcataatgct ttcaaaggac atagcagagc ttttgtggag tatccgcaca     6480

acattattta ttatctatgg actaaatcaa ttttttgaag ttgctttaaa atttaaaagc     6540

acctttgctt aatataaagc cctttaattt taactgacag atcaattctg aaactttatt     6600

ttgaaaagaa aatggggaag aatctgtgtc tttagaatta aaagaaatga aaaaaataaa     6660

cccgacattc taaaaaaata gaataagaaa cctgattttt agtactaatg aaatagcggg     6720

tgacaaaata gttgtctttt tgattttgat cacaaaaaat aaactggtag tgacaggata     6780

tgatggagag atttgacatc ctggcaaatc actgtcattg attcaattat tctaattctg     6840

aataaaagct gtatacagta aaa                                             6863


<210>  4
<211>  2603
<212>  DNA
<213>  Homo sapiens

<400>  4
gcatgttgcg gagtgattag tgggtttgaa aagggaaccg tggctcggcc tcatttcccg       60

ctctggttca ggcgcaggag gaagtgtttt gctggaggat gatgacagag gaatctgaga      120

attgctctca cacaccaacc cagcaacatc cgtggagaaa actctcacca gcaactcctt      180

taaaacaccg tcatttcaaa ccattgtggt cttcaagcaa caacagcagc acaaaaaacc      240

ccaaccaaac aaaactcttg acagaagctg tgacaaccag aaaggatgcc tcataaaggg      300

ggaagacttt aactaggggc gcgcagatgt gtgaggcctt ttattgtgag agtggacaga      360

catccgagat ttcagagccc catattcgag ccccgtggaa tcccgcggcc cccagccaga      420

gccagcatgc agaacagtca cagcggagtg aatcagctcg gtggtgtctt tgtcaacggg      480

cggccactgc cggactccac ccggcagaag attgtagagc tagctcacag cggggcccgg      540

ccgtgcgaca tttcccgaat tctgcaggtg tccaacggat gtgtgagtaa aattctgggc      600

aggtattacg agactggctc catcagaccc agggcaatcg gtggtagtaa accgagagta      660

gcgactccag aagttgtaag caaaatagcc cagtataagc gggagtgccc gtccatcttt      720

gcttgggaaa tccgagacag attactgtcc gagggggtct gtaccaacga taacatacca      780

agcgtgtcat caataaacag agttcttcgc aacctggcta gcgaaaagca acagatgggc      840

gcagacggca tgtatgataa actaaggatg ttgaacgggc agaccggaag ctggggcacc      900

cgccctggtt ggtatccggg gacttcggtg ccagggcaac ctacgcaaga tggctgccag      960

caacaggaag gagggggaga gaataccaac tccatcagtt ccaacggaga agattcagat     1020

gaggctcaaa tgcgacttca gctgaagcgg aagctgcaaa gaaatagaac atcctttacc     1080

caagagcaaa ttgaggccct ggagaaagag tttgagagaa cccattatcc agatgtgttt     1140

gcccgagaaa gactagcagc caaaatagat ctacctgaag caagaataca ggtatggttt     1200

tctaatcgaa gggccaaatg gagaagagaa gaaaaactga ggaatcagag aagacaggcc     1260

agcaacacac ctagtcatat tcctatcagc agtagtttca gcaccagtgt ctaccaacca     1320

attccacaac ccaccacacc ggtttcctcc ttcacatctg gctccatgtt gggccgaaca     1380

gacacagccc tcacaaacac ctacagcgct ctgccgccta tgcccagctt caccatggca     1440

aataacctgc ctatgcaacc cccagtcccc agccagacct cctcatactc ctgcatgctg     1500

cccaccagcc cttcggtgaa tgggcggagt tatgatacct acaccccccc acatatgcag     1560

acacacatga acagtcagcc aatgggcacc tcgggcacca cttcaacagg actcatttcc     1620

cctggtgtgt cagttccagt tcaagttccc ggaagtgaac ctgatatgtc tcaatactgg     1680

ccaagattac agtaaaaaaa aaaaaaaaaa aaaaaaggaa aggaaatatt gtgttaattc     1740

agtcagtgac tatggggaca caacagttga gctttcagga aagaaagaaa aatggctgtt     1800

agagccgctt cagttctaca attgtgtcct gtattgtacc actggggaag gaatggactt     1860

gaaacaagga cctttgtata cagaaggcac gatatcagtt ggaacaaatc ttcattttgg     1920

tatccaaact tttattcatt ttggtgtatt atttgtaaat gggcatttgt atgttataat     1980

gaaaaaaaga acaatgtaga ctggatggat gtttgatctg tgttggtcat gaagttgttt     2040

tttttttttt taaaaagaaa accatgatca acaagctttg ccacgaattt aagagtttta     2100

tcaagatata tcgaatactt ctacccatct gttcatagtt tatggactga tgttccaagt     2160

ttgtatcatt cctttgcata taattaaacc tggaacaaca tgcactagat ttatgtcaga     2220

aatatctgtt ggttttccaa aggttgttaa cagatgaagt ttatgtgcaa aaaagggtaa     2280

gatataaatt caaggaagaa aaaaagttga tagctaaaag gtagagtgtg tcttcgatat     2340

aatccaattt gttttatgtc aaaatgtaag tatttgtctt ccctagaaat cctcagaatg     2400

atttctataa taaagttaat ttcatttata tttgacaaga atatagatgt tttatacaca     2460

ttttcatgca atcatacgtt tcttttttgg ccagcaaaag ttaattgttc ttagatatag     2520

ttgtattact gttcacggtc caatcatttt gtgcatctag agttcattcc taatcaatta     2580

aaagtgcttg caagagtttt aaa                                             2603


<210>  5
<211>  12064
<212>  DNA
<213>  Drosophila melanogaster

<400>  5
atcgatttcg ggcagtcgat aaaacaacag ttcggagtgc agcaaaagtg cgggaaatct       60

gcggaaatgt tattaatcga acattaaggg atacctcgcc cagccgcgct ctagcattca      120

ccatttccct ttgtttgcgg cggcggcgct cgttgtacgg ccgtgcgaat cgagagaaaa      180

acgcataaaa tcggggaaag tgcactagcc ccgtgctgca atgtaaataa acaaggctct      240

gatgagcagt tgccgatcaa gtgcttcgat tagccagcaa aatgtgcgta caaggcgaga      300

atcagtgacg aaaacaacaa ctacgtgctg ctgcgttcat tgacgtgacg cgcgagagtg      360

aatgtgtgcg tgcgtgtgtg tttgtgtgtg tgtgctggct gctggcgagt gagtgtgtgc      420

gtgctcccca tatgtgtgtt gtcgaaaaag cgtttttcaa accacaagcc agcaacaaac      480

aaatcacaac agcacgtcac aaattgcaat agaagcagaa gcagcaacac ctcaaatcaa      540

aaaaaggccc cacaacaaca acatctgtcg agttctcaga gagtgagaaa aagaaagagc      600

gcgttagagt gagagagggg caaaaagaaa gtcaacagtc gcgtgtgaaa tgaaattcga      660

aagatgtccg cgtgtgtgtg tgttgagtgt atagaattga gtaagaagca gcgcggcaaa      720

aggaaataag caaaagcaat agccaaaagg aaccaacaac cagcagcaac aaattaccca      780

atgaatcaat caaaattggc ataatttgca ttcgccgacg ttattgtcta taaaaccccc      840

ctgaaaaaaa caccacacaa cagaagagca gcacaaatct tttgccaatg agtcgcagac      900

agtcattgga tcgaccagga atattgtctc ctccgggtcc gtttctgacg cccagtccat      960

cgccatcgat ctcagctagc cctcgtctgc aaccatcgcc atcgctctcg ccgttcccac     1020

aggatgtggt gctcgtagcc ggtggcagcc aagtaaacgc caacagcaat ccccaggaac     1080

acgagcgcaa ggcggcgacg cctggcagga gacagtccat ccaccagttc accaatggca     1140

gtcccaatgc tggaactgtc gtcttccagc cgagcccctc acaatcgccg gccgctgcca     1200

cgacggtcat cggcgtgacc agtggtggcc tcatagccac cgccgccgga ggaactggag     1260

ccggtctgag taccggagta ggagccggga gcagttccgg agtaggaatt ggcgtcgcgc     1320

tgcacggaaa tgccatcggc aacgagctga atgccactct ggtgggatcg aataatatcc     1380

agctcaataa gaagggcaca aagcgggcaa cccagcagca gcagcaacaa cagcaacagc     1440

tgggacacca gatcttcagc agcacagttg cacccacctc gatcagcagt gcgactgcgg     1500

tggcaggcgg cggcgggggc tatggacagt tcaatgccac cgccatcagc acgcccacct     1560

cgttcgccac ggccggcagt gtggtcagca gcagcgccaa aggtccgacg aagggtcaga     1620

aggggcagca gcagcagcag cagcatcagc agttccagca ctaccagagc agcagtcccc     1680

tgatagcgga cagtcccatc ccgagtccca gcggcgccat tgcagcggcg gcgattaagc     1740

ctccaacccc gcagccccaa caaatgcaga tgctgcccca gcagttcacc atctcccagc     1800

agccgcagca gcagcagcag gcgcagcagg tcttccagtt tatccaggga ccgcagggcc     1860

agctcatagc caccactccc cagcaacagc agcctatcca gcagcagcaa cagcagcagc     1920

ctcagccagt ccagcagcag cagcagcatc gattcgttag caatgccgga gtcacgggaa     1980

tgtccaccgg caagaccggc aaggcaccgc agcagatact gcccaagccg caacaggagc     2040

tccagcagca gaagaagggc acgaacggcg gagcacagat ctcgcaatcg gcgcagcaaa     2100

ctggccaagc caacaatccc acccaacagc agcaacaaca acaacagcaa cagatcctgc     2160

tacctgccac caccaaccag ccgcaacagt tgctccttaa ccaaatgccc gtgctggtgc     2220

aacagaatcc gcagggcgtg cagctaattc tgcgaccacc tacgcctcag ctgacgacca     2280

caccgtccct cgtcatccag cagaatgccc gcgggcaacc ccaactgcag acgcagccgg     2340

cacagcaaca actgctgcgg atagtgggca ccaatggagc gacaatgcag ctggctgccg     2400

cgcccacctt cattgtgtcc tcgcaggcga acctcatcca tcagacggcg gcaggtcagt     2460

tccagagcgc catcaagtct ggcacccagc tcacgggtct gcatgcggct ctagcacagg     2520

cacaggccca ggcgcaggcg ccacgatctc agccgtttgc cacgacggcc acgttgaaca     2580

cccagctcct tggccagagt gtagccgccc agctgcagaa cttacagctg gctgcggccc     2640

aaattcagat gcccaacggc ctcaccgcca tatcccaact gccagctcat ttgcagcaga     2700

gcctaggtgg agccaccatc aatctgaatc agctgaatgg ggcgcatatc cagcaaatag     2760

ctaacgcttt tcaggcgcca caggctccag gaacgaatag cggaggagct aacagcacga     2820

cggagctctt tacacaatcc tcgccggcac atgtgccgct ggccgtcacc ccggagccat     2880

tgcgtcagcc cacgcccgtg cccatgatgc agcaacaaca acaggctgcg atggccacca     2940

ttcagttgca gcagcagcag caacaacagc agcaggcgca gatacagcag ctgcagcatc     3000

aactgcagca aacacagtcc caggtgcagc aagcccagca atctgtccag gcgacaacta     3060

taccggagcc caagaagaaa ccgcgacccc gcaaaaagaa gcaacctcca gctccaactc     3120

caccagcagc ctctccgaca gtagcacccg ctgaagtgag acccccgacg ccacaaaaga     3180

tagccatcgc cgccacgccc gcgccacagc caactgtacg cgccaagtct ccatcgccac     3240

ccccaacgac gatccagcga agtagcaatg gaaagctgga tctcggcgat gtgatgaagt     3300

tttgcggtat caccggagac gatgacgacg acgaggacta tggaatgggc ctagaaacag     3360

ggctagcatc agaatcagag ccagctcaag cccacgcgcc tgccacaggg agtgctgcag     3420

cgacgacggg cagcagcggc gacatcatga tctccatacc gaaccaaaat ggcagcgatg     3480

gcctgccttt taccttgacc atacccgctc cgcagcccca gtcatcgacg ggatctcagg     3540

cggcgggaaa cgaatcagcc accgaaatac caaatatcct catcaaaatc gatccaagtg     3600

ccgaggcagc ggtgccgcca tttggtctat ccacgccacg gttgcccaca gcagaggaaa     3660

ttcagaagca ggcgcagcaa catttggcac aacaggcggc cgctgcagca gcggcggcaa     3720

aggcaaccac agccacgccc accataaaca ttagcctgcc tagcatgaca ttgcagccgc     3780

aggtagcgcc ggcaccagtt gtgacgccaa ctcctgcccc atcctcgaac caggtgtcca     3840

cgacagttgt tgtcaaacca agaaggaagc ccgcggtgcg aaggaatgcc aagaaacctg     3900

acgtgaccag cagcgcaagc aatatgatct cctcgagcag tggcactacc actacaatca     3960

gcagcagcac tagtaccatc ctaaacaaca gtcaacccac cactgtaaac accatcactt     4020

taaccacgcc cacgccagtg acaagcagca gcaattccac cctgatgctg acccacggaa     4080

ctccgacagc agtgcccagt cagattggca acattcagat ctcacaggtg cataatcatc     4140

acccatccgc attgccggtg agcagtgcgg tggagaacaa gatccagata atgccgatcc     4200

tgccaccggg agccacagtg atgggcggaa caccaggaac cggaggtcat gcccccacca     4260

cccaatcaac ccagttggtc tttcagccag cggcaccatc ggtggcgcct acgattactt     4320

cagactccac tgggtttaag ctctccagcg atggtcggca aatgcagcta gtggccatac     4380

cacaggcgac tcctccatcg ccagcagcca gttctgccca gccaccggtt cccacgccca     4440

ctcctgcgtt aactgccgga ggagctacaa ttctgccacc tcagttgaca ggaatgcccg     4500

ccaatgtatc ggtttctgtg ggatcccctg cctcggctgc ggctctggtg ccacaactca     4560

ctggaagtct cacactcacc gtgtcggagc agtgcgagcg attgattctg cgacatgatc     4620

cgaacaatcc ccaggaccat caatcgcagc tcatcctgca ggctctgctc aagggcgctc     4680

tgcccaatgt taccataatc aatgagccga cgcgcgtgga tccaaataaa cagacaactc     4740

cgatgttgca gccgcaacag caagttatcc aaatacccca gccactaact caaccccagc     4800

aaattctgca gcagcaacca aaggtttcaa cagctcccaa aatagaagtt aaagtggcta     4860

acaacagaaa gttgtcaggt caggtaacac atcctgccag cagtatgtta ggaatgacca     4920

gcactacaac taccatgtca acgatgaaac caccggccaa tctacccgcc aagcagaacg     4980

aagtcgtatc tttcccgcag ctaccactga actcgcaggt tctcattcag cagcagccta     5040

tgatttctgc gcagctacag cctcagttgc aacccgtcac tgtgcccgtt agcttgccca     5100

ctcagccggt accgattcca tctccggcgc ctgctccaca actggccaac aatggccagc     5160

agcggtacat tgcactgccg cccattgatc ccaccaccca gcagttgttc tgcctgaaca     5220

gtgtcacgaa tcagataact gcgatgagtg cgggccagac ggctgcttcg attggtccca     5280

ccgagcggtt gcttattgct ccggctggta tcaatgctca gcagctggct caatgtctgc     5340

agttggggca acttcatttc aatgatgtga atccgctgcc ggctcagcag caacagcagc     5400

aggtggctac cacctcgtct tcgatgacac tttcaatgcc actgcgtcct cagccaccgc     5460

agcaacaaat agtgcatccc atccagccaa tcacaaatgg actggccatc accacaacgg     5520

caagtagcac gctgaccacc accactagca ccacttcgtt aacaacggtg accaagcagg     5580

tggccaatgt ggcgccgatt atagatcaaa gcaaagcgaa gctggagccc gctaaggcag     5640

ccaccagtgg agccggtggc ggagcggtgg tcaaaaagaa gccggtgagg aagcccaagg     5700

caacgccgac caatgcctcc gaactggcca atctaaagaa cgccagcgta gtcaagccaa     5760

tgccaaagct cgatccccta tcgcaaaagc ccaacaataa cccggtgcag atcgtgcagc     5820

ctaatgttgc cagtggaaag cagatgattg tggtgggcag ctccagttgc acaacaacta     5880

ccacgacaac gatgagcgcc agcatccagc ccttccagac aacgagtggc accaaattgg     5940

tgggcgttac ggtgcccatg cagcagcaac aacccactgg cacggcagct atattgcaac     6000

agcagcagca acagaggacg agcttcagct tgacggcaac cacagtggcg acacctgctc     6060

cgatgccatc tccaacggta gcgtctgggg tcagccaact ccaaatgcag caacttccat     6120

cccagcaggc gcagcaacag ttgcagccgc agcagcagca acagttgcac gctcctaagc     6180

aacaacaacc gcaaccaaat actgtgtccc gggtgcaaac catccaactt acgcctcaga     6240

tgcaacagat cttcaagcag gtccaaatgc aaattcagtt cctcactatt aagttacaaa     6300

ataaatcaac cttcttgccc gtctcgccgg aaattgattc ggcaactatt gccgcctaca     6360

acaaaccgat gacagatgcg gagataaatc tggctctgca gcgtctcttc gcagagcagc     6420

accggattct ggcctccggc aaagaggtac ccactccaga gggtatgttg ccaacagcaa     6480

atggaacggg cggcttcagt ctcatgccac aaccagttca acaacaacaa cagcagcagc     6540

agcaacagtt gcaatcaact gttcctgagc cactgaaaac aatcgttccg gccaatgtgg     6600

ttcagccaaa caaccactca tccactcctg caggagcggc cactagtggt gccacaactg     6660

ctgccaatat ccagcagaat ataacacaga ggatacacat ctaccctatg cagcaccaac     6720

aacaacaaca gcagcaacaa cagcagcagc aacaacagcc gcagcatcag caacaacagc     6780

cccagcatca gctacaacag accggagcca aaccaaagca ggcacaacca aagccgccgc     6840

cacagcagga gcaacaatcg caactccaaa taaaacccaa ggaaccggcc aacaggagca     6900

aagtgactag ccagcagctg cagcaaaatc ctcagccacc caatggaacc atcaatatgt     6960

tgccacaaaa agttagcatg atgccggttg tccagcagca acagcagcag cagccgcaac     7020

aacatcagca gcaaccaatg ctcaacaaaa gcgggccacc tccactgatc ttcgccagct     7080

ctacaaatat gctgagcaac agcaatagca acaacctcca caacagcaat tctgcaatgc     7140

aagtaaacaa catgttgccc ctgccaccat tgcaacccca acagcagcct cagccacagt     7200

tacagcagcc accaactcca atcctgccgc cagtagcacc aacaatggcc atgggagtgg     7260

cgccaggacc gatgggaaat ctagtgccat ccctcccgac cataccgagc ctgcccctgt     7320

atatgccgag caaaatggac gaaatgccaa cacagaaacc aaaaattgca cgcctctcct     7380

tgttcgttcg ccaactggag gtcgatcagg agagctgtct gaagccggat tacgtgaagc     7440

ctttccgcac aaaggatgag gcggttaaaa ggctaatcag gtatcattgc atgcatgaga     7500

acgacgttga gttgccttct gacgaagacg aggaatttga gtccactgct ctggaattcc     7560

aggacaaatt ccgccaactg aacggcaagt tccaggaaat tctgatgcag gagtcaacgc     7620

tgccacaccg aacttctgag ttgctacaaa tgcagcagct gatgatcgat gatctcaaag     7680

gcgagatcaa tgagattcga accgctgaaa aggagttaga gcagcagcta aaggaggagc     7740

agactagcga aaaatcgacg gcggaaagcg atgtactttc ggaggcgaaa gttaaggagg     7800

agattaaaca ggaaccaata gataagtctg ctcagccaga cggcgttgtt gacaaatttg     7860

atttgctgaa aaacagcgct gatgtcaata aagcattcag caagtcacag ccacagcaga     7920

ctactacagt aaagcaagag gagagcaacg aatctgggga accttctgta aatggatctg     7980

taaagagcga aggccacgat aaggagtcgt cgaaatacat taagaaggac tacgacaact     8040

tcgacattga gtctgagctc accactagct tcatcatgaa gaaggtggag aacaaagcgg     8100

ctttggcaaa gagcgctgag aatcgctacc aggaaagaaa tatgatggac caacaacagc     8160

agcagcaaca tatcaaagcc aatggaggag atcccgtaga ccaggatgat ggctggtact     8220

gcctgcaaaa ggagcttaac ctgatgaata acgatcatat gcagcaatcg cagcaacaac     8280

taaatggaaa ccaacagcat ctgcccatca atcgtcaacc ggcgccacag caatcacact     8340

tcctggacaa ttcaaattcg aacaacatga tgggcaatag caaccacatg tcggatctgt     8400

tccccaatgg ttgcattgac aagagcaatc aaagcaccac cagcagcagc aatagcagtt     8460

gcgttagcga aagccttcct ggttctaatc ccgtgaagac tgtctcctca tgcagcggcc     8520

agcgcgaaca gccggtggtc atggatgctg atcagcaaaa cgagcatccc gccatcagtg     8580

agttctttag cagcgattcg gacgtccaga aatccgtgga gacacgactc gaggcaatgt     8640

tcggggagtc gcccgtccat ttggacgtta agagcagcaa cgatgccaac gacattgagt     8700

ccaacctgga cgagattttt ggcgactcga aatcgccagc tgccaaccac aaaagtaaaa     8760

tgagcatgtg ggtgccagac gcatcattta tgcagcaggc gccgcagcaa cagacgtcgc     8820

aacagcagca acaatacgca gggccacaac aaccatcaca gcagcaacat cacatcgaac     8880

tgaactgcaa caacaatccg cgctggatgc aaagcatgga ggcgcactac agcgactttc     8940

tttccaccgg gactagcaat ggagagctgg tgaacggaga atcgcgaaaa agaagctggg     9000

atagccagct catgggctct ggcagtgata tggaagatga caacagcagc aagcgtctgt     9060

gcacggcttc atcgtcctcc tcttcgtcgc ccatgtcgtc gcagcagcag cacgttcagg     9120

tggcacagca tggtctcttg gactcggaca tgttccccca gatgttgatg gatcagcagc     9180

cgcatcagca acaacagcag gtacagcagc aacacaactt tgcctacgcc aacataatgg     9240

atcaacagca gcagcaacag caccagcagc aacatttcca gcataacctg cagcaacaga     9300

tacaacagca gcagcagatg catgttagcc acatgggcgg agcagcagta gtggccggcg     9360

gagagtacga cgatgacatc agtcggcatg tggccagcgc catcgacagc atcctgaact     9420

tgcagaacag cggcgactcg ctgcagttct ccctgggttc gatcctcggt gacagcatgc     9480

tggacgatca acggcaagca ggagccaatt tgcccagctg ccagcaggag caggcgatcc     9540

aacgacgccg ccacctgggc gaggagatga acgactgcct gattagcggc ggtggttccg     9600

cggttagcgg agtggcggac aacagtagta acatactgct agagcaccac caccagcagc     9660

atcagttgat gcagagccac caacagcagc cgcatctgca gcatcaccac catcagaaca     9720

tgtcgcaggc ccaggcgcag cacatgggac agctgaacga ctttagctgt gtagccggtg     9780

gcttggacga tcctgtcaag tcgataatga cgtcctgact tggagcccca agcagcacat     9840

cagcggcgga aaatgcttcg aacagtctga tactagagtt taatgccacc accttgtgaa     9900

aaacggatga taataatgac ttcctgattg tatagatacc cgtcttagtt gtccttggtt     9960

attgttttac ccccgagtac aacctttaat tagatctaag ttgaatccgt gtagcataaa    10020

ttgtttttac ttattgtttg tattgtttag ttcaatgatt tgtaccatat ttgaacagcc    10080

ctcagataac caattactta atgcaagggg acagaacgaa gagagcgagg tgaaagtaat    10140

ggcatctaca tacaatacgg ctgagcccca ataaagctac gaaagcaatt gacgtggtga    10200

attgaaaact aaacgacgaa tagcatcaaa tgcttctcac agaggtacac taaaatggaa    10260

cataatataa aaaattatat agctacagta actaagagaa agcccctaga caatttatac    10320

aaatgaaacc aagaaagtac gtaagataaa gggaagaagg taacgatggg aataaacacg    10380

cgcaaagtga gagaaatgaa aggaaaacga attggttgta taacttataa ttaagttact    10440

tgaagcaatt ctgagaaaca attaaaatca cgttgccaat tttgttgtcg tttgaatatc    10500

aggcagagca atttatccgc atccaatcga tttttaaaag cccagataaa atatatttat    10560

ttacgcacta cgttgcgaag gagttttgta aatagttaga acatgcagca gtttcagtat    10620

atataaatat atagctaagc atttttaaaa ggatatcatt taaagcgctt caagtacgac    10680

tgcttctgat attacagaca aaccaacaaa ccaaccaacc aaccaatcaa cctattgacg    10740

tgctcaatat gagagtaaag aatatttcgg catagctacg ggtgtcattg gaaagcaaat    10800

gcaaagatct tagggattaa cgagtaccaa ctatggcaaa ctacgaagca aaccaaaagc    10860

agttcaaaaa tcacaatttt agccaattta gtttaaacat ttataaatta taaattattg    10920

aatctaatgt aatatcttat acacttaaac cgatcgattg aaacgagaag ctagcagttc    10980

tgagatgagg aaccccagga aaacaaataa caacaaatta acgaatcgta tcaattgtat    11040

ctcgatcttg cgacaaatct gacttgtgat ttgtgccacg ttttaaatat agatgtctga    11100

ttagcttgta aacatacata ataaatacga ttaaaaagtc tatacaaaag cccacactca    11160

gtaagccact acgaagttta tccaaaatga atcgcgactc gcggtagcaa ttgtaaatgt    11220

ttgacgtggg gagggcgggc gccacgcatc aattacatac caattacaat actaactact    11280

actttaatac caccactaac acacctacta cgatacgtac taccgtggac ggattgcttg    11340

tattacgtgt agtctgtaag ggaaattcga gaggtaccat attttaagat gtgcttcgtt    11400

tgttcaagtc cacccatcca tgacccatga cccatgaacc ctgaccctga actcctgtac    11460

caaaacccga atcataacca taaccatcca ctcccacaaa agcaaagtct cccacctgcc    11520

tagcgtcccg tgtgagttgc atgatcttgt atttctattt ggaaactttc tagttattat    11580

tcaaagacaa ccactttcgt gtaaaaatgt atatgtaata gcataattta agttggcaac    11640

ccaaaactga ataaacctaa ttctactgat agataactaa tgcgaattgt tttaagttgt    11700

atttagaacg aaatcgaaat cctcagaact caaatcggtc gcccctcccg caaccaactt    11760

tccacaacaa caaagcgcag tgtcgtcact tgaattgttc agctaaatgt gtctaaatgt    11820

aattaaacat aaagagaaaa ctaaagattt ttaaacaaac attgtgagtt ttattaaaca    11880

tcatcagcat agggagagga gaggacagca gcaaagcaaa ggaaaccaac atctttaata    11940

tttgatagtt tattaagccc atccattcat agtcgtcata aacattaagt acataaaaga    12000

aaaacccaac aaaagattca atataaatct cactgaaacg caacaaacaa ccgaaaaccc    12060

aact                                                                 12064


<210>  6
<211>  3921
<212>  DNA
<213>  Drosophila melanogaster

<400>  6
gctcattaac gtttcgcttg gctaagtgcg cacctcgtca ctgaaaccag ttagcaaaag       60

aaatttttgt tcaagcttaa accgatacct acgtcactat tcgatcattt tgaatgcaaa      120

ttattcccag attaataaac taggtcgcca tccgtggcgc tgccgccggg ctgcggaccc      180

gtactttcga cggaaaatat cgggaccatt ttcataaacg atctatgata cagttttaaa      240

acactttaac gctttccatc gtgcacactt aaaacaaaac tcataaagtg aaagttcata      300

tcctggcaag taaaaagtga taaatgttaa aacgtctgaa gtgatagtct ggagtttgat      360

taccaggtga agaagataat atatatggga tgtacaaagt tggcaacgaa gccccccttc      420

taacaacaat gaaaaaggga gtaatcctac tttctcactt tcaataataa acatacgcac      480

gtcagccacc gtcgaagtct ccaacgccgc attaaaaata attaattatg atgctaacaa      540

ctgaacacat aatgcatggg catccccact cgtcagtcgg gcagagtact ctatttgggt      600

gctccacggc gggccatagc ggaataaatc agctgggcgg cgtatatgtt aatggccggc      660

cactgcccga ttcaacgcgt caaaaaattg tcgaattggc tcattccggc gcacgtcctt      720

gtgatatttc aagaatacta caagtgtcca acggttgcgt aagcaaaatt ttgggcagat      780

attatgaaac tggatcgata aaacctcgag ctataggtgg ttcaaagcca cgagtagcta      840

caaccccggt tgtgcaaaaa attgcagatt acaaacggga atgtcccagc atatttgcgt      900

gggaaatacg agatcgactg ctatcggaac aagtttgcaa tagtgataac attccaagtg      960

tttcatctat taatcgagtc ttacgtaacc tggcctcaca aaaggagcag caagctcagc     1020

aacaaaacga atccgtttat gaaaagcttc gcatgtttaa tggccaaacg ggcggatggg     1080

catggtatcc aagcaataca acgacggcac atttgacgct accaccagca gcttccgttg     1140

tgacatctcc tgcaaattta tcaggacagg ccgatcggga tgatgttcaa aaaagagaat     1200

tacaattttc agtagaagtt tcgcatacaa actctcacga tagtacatcg gatggaaact     1260

ctgaacataa ttcatccggg gacgaagact ctcaaatgcg gttgcgccta aaaaggaagt     1320

tacagcgcaa tcggacatca ttttctaatg agcaaattga cagtcttgaa aaagaatttg     1380

aaagaacaca ttatcccgat gtttttgcgc gagaaaggct tgctgataaa attggtttgc     1440

cagaggcacg tattcaggtt tggttttcaa accgacgagc taaatggcgc cgagaagaaa     1500

aaatgcgaac tcagagacga tcggccgata ccgtggacgg cagtggtcga accagcacgg     1560

caaataatcc ttcaggaaca actgcatctt cctccgtcgc aacgtcaaac aactcgactc     1620

cagggattgt gaactcagca atcaacgttg cggaacgaac atcatctgca ttagttagta     1680

atagccttcc cgaggcttca aatggaccaa ctgttttggg tggtgaagct aatactacac     1740

acaccagctc tgaaagccca ccccttcagc cagcggcacc gcggctaccc ttaaattctg     1800

gattcaacac catgtactca tctattccac aaccgattgc aacgatggct gaaaattaca     1860

actcctcatt aggatcaatg accccgtcat gcttacaaca acgcgatgcc tatccttaca     1920

tgtttcacga tccgttatca ctaggatctc cctatgtgtc agcccaccat cgaaacacag     1980

cttgcaaccc ctcagctgcg caccaacagc cccctcagca tggcgtttat accaatagtt     2040

ctccaatgcc atcatcaaac acaggtgtca tttctgcggg cgtttcggtg cctgtccaga     2100

tttcaacgca aaatgtatct gacctaacgg gaagcaatta ctggccacgt cttcagtgat     2160

cgtcaatctt tggctcacca ttagatcatt tgtcaaaggc gactgccgct gcaatcattg     2220

ccgcacaagc agctgagaaa agccataaac accgaaaaga gcattcaatt gttagtatac     2280

acaccacaaa aagaaagaaa aacccaccta gtttgaagag acagacaacg tgctgttcat     2340

ccagatattt aaacatgacc ttcggggcgg ggaaggatgt agatgttgtc ataggccaag     2400

gtcttatagt gtccttaaca ccacatattt caggaaagcc ggagcttttt ggtagtccta     2460

acgttaacta ccatcaggac tttcaagtaa tttaaatagg ctgaaccttt tcggtctgaa     2520

acttgtgaat tgcacactat atgtatttta aaaggcaaat gaaatgttaa atctacatta     2580

aaattgatgt tatttttgaa taaaaattca agatttgtaa acaatatttc cgcatctttc     2640

gcatcctttt ttaagttcca aacattcctg atctgctaag ataggttaaa gtatttcggg     2700

gaatcttcaa ctttactgtt gataagcacg caatcgggat attagacttc tgcagttgct     2760

tgcaattttt taagccttca caattatatt tatattttga accatttttt gatattataa     2820

attaaactta ttcatgtatt aatactattt attaatcgtc tttaagtaaa gaatgagcaa     2880

ttatgctcat acatacttaa aaaaaaaacc atgtgttacc aaacttaggg aagtgcgtgg     2940

aagacggata taaagcaaag tgacgttata catgatttta catttacatt aaattcttat     3000

atgacaattt atgtttttag agtcgtaggc gttatatagt ttcttctact agtaacgtac     3060

ttctaaacaa atctctcata cccttttcct ctacgattat atcaccaaat tgttttgttt     3120

cccaaatata accattgcat tttgaattaa aaattacatt tttttaagtt caataaaaac     3180

taccagataa tgctaattaa aggtcttata aacattttga cgaaattatg actttgaatt     3240

atatatatac atttaagtac acgaacaatt tctactgtac gtaactatta aaagatatag     3300

tgtttctaat ttgatcggca tgaaataaac taaaaccact gattcatttg ctagaaaacc     3360

cataaacctc ataaaaataa ataaaaaaca tttcgcgcat actggtcgat atgttttaaa     3420

aattgtatat tttattataa tgtattcaaa ttataaatta tctgtacatg attcttttaa     3480

atgtaagcta ttagttatta atccatgtgt acaccgtttg taaaacagaa acttataaca     3540

acgtaagatt gaatgaattg caacgaactt gactccaatg aaggaaatga gctaacatct     3600

catccagata aacaccaacc ccaacaagcc ttcaggttta tatcataata ataaaatgtc     3660

gtatatgtat aatgtatggt tcaaatttat atttagaata aattaatgta acatttcaga     3720

atatacaggt gtatctgttg ttcttaaaag gggcttaatg aaatccaact ttaataaaaa     3780

acaagagaga atgctatagt cgagttcgtc gactattaga tacccgttac tcagctagtg     3840

tgtgaccgtt ttggctgcaa aaaacgatag aaatttacac aactaataaa atttaaaaaa     3900

aaaatattca aaaaaaattt c                                               3921


<210>  7
<211>  3684
<212>  DNA
<213>  Homo sapiens

<400>  7
acactttaat atcaacctgt ttcctcctcc tccttctcct cctcctccgt gacctcctcc       60

tcctctttct cctgagaaac ttcgccccag cggtgcggag cgccgctgcg cagccgggga      120

gggacgcagg caggcggcgg gcagcgggag gcggcagccc ggtgcggtcc ccgcggctct      180

cggcggagcc ccgcgcccgc cgcgccatgg cccgaagacc ccggcacagc atatatagca      240

gtgacgagga tgatgaggac tttgagatgt gtgaccatga ctatgatggg ctgcttccca      300

agtctggaaa gcgtcacttg gggaaaacaa ggtggacccg ggaagaggat gaaaaactga      360

agaagctggt ggaacagaat ggaacagatg actggaaagt tattgccaat tatctcccga      420

atcgaacaga tgtgcagtgc cagcaccgat ggcagaaagt actaaaccct gagctcatca      480

agggtccttg gaccaaagaa gaagatcaga gagtgataga gcttgtacag aaatacggtc      540

cgaaacgttg gtctgttatt gccaagcact taaaggggag aattggaaaa caatgtaggg      600

agaggtggca taaccacttg aatccagaag ttaagaaaac ctcctggaca gaagaggaag      660

acagaattat ttaccaggca cacaagagac tggggaacag atgggcagaa atcgcaaagc      720

tactgcctgg acgaactgat aatgctatca agaaccactg gaattctaca atgcgtcgga      780

aggtcgaaca ggaaggttat ctgcaggagt cttcaaaagc cagccagcca gcagtggcca      840

caagcttcca gaagaacagt catttgatgg gttttgctca ggctccgcct acagctcaac      900

tccctgccac tggccagccc actgttaaca acgactattc ctattaccac atttctgaag      960

cacaaaatgt ctccagtcat gttccatacc ctgtagcgtt acatgtaaat atagtcaatg     1020

tccctcagcc agctgccgca gccattcaga gacactataa tgatgaagac cctgagaagg     1080

aaaagcgaat aaaggaatta gaattgctcc taatgtcaac cgagaatgag ctaaaaggac     1140

agcaggtgct accaacacag aaccacacat gcagctaccc cgggtggcac agcaccacca     1200

ttgccgacca caccagacct catggagaca gtgcacctgt ttcctgtttg ggagaacacc     1260

actccactcc atctctgcca gcggatcctg gctccctacc tgaagaaagc gcctcgccag     1320

caaggtgcat gatcgtccac cagggcacca ttctggataa tgttaagaac ctcttagaat     1380

ttgcagaaac actccaattt atagattctg attcttcatc atggtgtgat ctcagcagtt     1440

ttgaattctt tgaagaagca gatttttcac ctagccaaca tcacacaggc aaagccctac     1500

agcttcagca aagagagggc aatgggacta aacctgcagg agaacctagc ccaagggtga     1560

acaaacgtat gttgagtgag agttcacttg acccacccaa ggtcttacct cctgcaaggc     1620

acagcacaat tccactggtc atccttcgaa aaaaacgggg ccaggccagc cccttagcca     1680

ctggagactg tagctccttc atatttgctg acgtcagcag ttcaactccc aagcgttccc     1740

ctgtcaaaag cctacccttc tctccctcgc agttcttaaa cacttccagt aaccatgaaa     1800

actcagactt ggaaatgcct tctttaactt ccacccccct cattggtcac aaattgactg     1860

ttacaacacc atttcataga gaccagactg tgaaaactca aaaggaaaat actgttttta     1920

gaaccccagc tatcaaaagg tcaatcttag aaagctctcc aagaactcct acaccattca     1980

aacatgcact tgcagctcaa gaaattaaat acggtcccct gaagatgcta cctcagacac     2040

cctctcatct agtagaagat ctgcaggatg tgatcaaaca ggaatctgat gaatctggaa     2100

ttgttgctga gtttcaagaa aatggaccac ccttactgaa gaaaatcaaa caagaggtgg     2160

aatctccaac tgataaatca ggaaacttct tctgctcaca ccactgggaa ggggacagtc     2220

tgaataccca actgttcacg cagacctcgc ctgtggcaga tgcaccgaat attcttacaa     2280

gctccgtttt aatggcacca gcatcagaag atgaagacaa tgttctcaaa gcatttacag     2340

tacctaaaaa caggtccctg gcgagcccct tgcagccttg tagcagtacc tgggaacctg     2400

catcctgtgg aaagatggag gagcagatga catcttccag tcaagctcgt aaatacgtga     2460

atgcattctc agcccggacg ctggtcatgt gagacatttc cagaaaagca ttatggtttt     2520

cagaacactt caagttgact tgggatatat cattcctcaa catgaaactt ttcatgaatg     2580

ggagaagaac ctatttttgt tgtggtacaa cagttgagag cagcaccaag tgcatttagt     2640

tgaatgaagt cttcttggat ttcacccaac taaaaggatt tttaaaaata aataacagtc     2700

ttacctaaat tattaggtaa tgaattgtag ccagttgtta atatcttaat gcagattttt     2760

ttaaaaaaaa cataaaatga tttatctgta ttttaaagga tccaacagat cagtattttt     2820

tcctgtgatg ggttttttga aatttgacac attaaaaggt actccagtat ttcacttttc     2880

tcgatcacta aacatatgca tatattttta aaaatcagta aaagcattac tctaagtgta     2940

gacttaatac catgtgacat ttaatccaga ttgtaaatgc tcatttatgg ttaatgacat     3000

tgaaggtaca tttattgtac caaaccattt tatgagtttt ctgttagctt gctttaaaaa     3060

ttattactgt aagaaatagt tttataaaaa attatatttt tattcagtaa tttaattttg     3120

taaatgccaa atgaaaaacg ttttttgctg ctatggtctt agcctgtaga catgctgcta     3180

gtatcagagg ggcagtagag cttggacaga aagaaaagaa acttggtgtt aggtaattga     3240

ctatgcacta gtatttcaga ctttttaatt ttatatatat atacattttt tttccttctg     3300

caatacattt gaaaacttgt ttgggagact ctgcattttt tattgtggtt tttttgttat     3360

tgttggttta tacaagcatg cgttgcactt cttttttggg agatgtgtgt tgttgatgtt     3420

ctatgttttg ttttgagtgt agcctgactg ttttataatt tgggagttct gcatttgatc     3480

cgcatcccct gtggtttcta agtgtatggt ctcagaactg ttgcatggat cctgtgtttg     3540

caactgggga gacagaaact gtggttgata gccagtcact gccttaagaa catttgatgc     3600

aagatggcca gcactgaact tttgagatat gacggtgtac ttactgcctt gtagcaaaat     3660

aaagatgtgc ccttatttta ccta                                            3684


<210>  8
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  9
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Thr 
        35                  40                  45              


His Ala Asp Ala Lys Val Gln Val Leu Asp Asn Gln Asn Val Ser Asn 
    50                  55                  60                  


Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile 
65                  70                  75                  80  


Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr Pro Glu 
                85                  90                  95      


Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser Ile Phe 
            100                 105                 110         


Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys Thr Asn 
        115                 120                 125             


Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg Asn Leu 
    130                 135                 140                 


Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp Lys Leu 
145                 150                 155                 160 


Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro Gly Trp 
                165                 170                 175     


Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly Cys Gln 
            180                 185                 190         


Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser Asn Gly 
        195                 200                 205             


Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg Lys Leu 
    210                 215                 220                 


Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala Leu Glu 
225                 230                 235                 240 


Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg Glu Arg 
                245                 250                 255     


Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val Trp Phe 
            260                 265                 270         


Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg Asn Gln 
        275                 280                 285             


Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser Ser Ser 
    290                 295                 300                 


Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr Pro Val 
305                 310                 315                 320 


Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr Ala Leu 
                325                 330                 335     


Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr Met Ala 
            340                 345                 350         


Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser Ser Tyr 
        355                 360                 365             


Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser Tyr Asp 
    370                 375                 380                 


Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln Pro Met 
385                 390                 395                 400 


Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly Val Ser 
                405                 410                 415     


Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln Tyr Trp 
            420                 425                 430         


Pro Arg Leu Gln 
        435     


<210>  10
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Thr 
        35                  40                  45              


His Ala Asp Ala Lys Val Gln Val Leu Asp Asn Gln Asn Val Ser Asn 
    50                  55                  60                  


Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile 
65                  70                  75                  80  


Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr Pro Glu 
                85                  90                  95      


Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser Ile Phe 
            100                 105                 110         


Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys Thr Asn 
        115                 120                 125             


Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg Asn Leu 
    130                 135                 140                 


Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp Lys Leu 
145                 150                 155                 160 


Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro Gly Trp 
                165                 170                 175     


Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly Cys Gln 
            180                 185                 190         


Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser Asn Gly 
        195                 200                 205             


Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg Lys Leu 
    210                 215                 220                 


Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala Leu Glu 
225                 230                 235                 240 


Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg Glu Arg 
                245                 250                 255     


Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val Trp Phe 
            260                 265                 270         


Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg Asn Gln 
        275                 280                 285             


Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser Ser Ser 
    290                 295                 300                 


Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr Pro Val 
305                 310                 315                 320 


Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr Ala Leu 
                325                 330                 335     


Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr Met Ala 
            340                 345                 350         


Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser Ser Tyr 
        355                 360                 365             


Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser Tyr Asp 
    370                 375                 380                 


Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln Pro Met 
385                 390                 395                 400 


Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly Val Ser 
                405                 410                 415     


Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln Tyr Trp 
            420                 425                 430         


Pro Arg Leu Gln 
        435     


<210>  11
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  12
<211>  3003
<212>  PRT
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (2977)..(2977)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Met Ser Arg Arg Gln Ser Leu Asp Arg Pro Gly Ile Leu Ser Pro Pro 
1               5                   10                  15      


Gly Pro Phe Leu Thr Pro Ser Pro Ser Pro Ser Ile Ser Ala Ser Pro 
            20                  25                  30          


Arg Leu Gln Pro Ser Pro Ser Leu Ser Pro Phe Pro Gln Asp Val Val 
        35                  40                  45              


Leu Val Ala Gly Gly Ser Gln Val Asn Ala Asn Ser Asn Pro Gln Glu 
    50                  55                  60                  


His Glu Arg Lys Ala Ala Thr Pro Gly Arg Arg Gln Ser Ile His Gln 
65                  70                  75                  80  


Phe Thr Asn Gly Ser Pro Asn Ala Gly Thr Val Val Phe Gln Pro Ser 
                85                  90                  95      


Pro Ser Gln Ser Pro Ala Ala Ala Thr Thr Val Ile Gly Val Thr Ser 
            100                 105                 110         


Gly Gly Leu Ile Ala Thr Ala Ala Gly Gly Thr Gly Ala Gly Leu Ser 
        115                 120                 125             


Thr Gly Val Gly Ala Gly Ser Ser Ser Gly Val Gly Ile Gly Val Ala 
    130                 135                 140                 


Leu His Gly Asn Ala Ile Gly Asn Glu Leu Asn Ala Thr Leu Val Gly 
145                 150                 155                 160 


Ser Asn Asn Ile Gln Leu Asn Lys Lys Gly Thr Lys Arg Ala Thr Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Leu Gly His Gln Ile Phe Ser Ser 
            180                 185                 190         


Thr Val Ala Pro Thr Ser Ile Ser Ser Ala Thr Ala Val Ala Gly Gly 
        195                 200                 205             


Gly Gly Gly Tyr Gly Gln Phe Asn Ala Thr Ala Ile Ser Thr Pro Thr 
    210                 215                 220                 


Ser Phe Ala Thr Ala Gly Ser Val Val Ser Ser Ser Ala Lys Gly Pro 
225                 230                 235                 240 


Thr Lys Gly Gln Lys Gly Gln Gln Gln Gln Gln Gln His Gln Gln Phe 
                245                 250                 255     


Gln His Tyr Gln Ser Ser Ser Pro Leu Ile Ala Asp Ser Pro Ile Pro 
            260                 265                 270         


Ser Pro Ser Gly Ala Ile Ala Ala Ala Ala Ile Lys Pro Pro Thr Pro 
        275                 280                 285             


Gln Pro Gln Gln Met Gln Met Leu Pro Gln Gln Phe Thr Ile Ser Gln 
    290                 295                 300                 


Gln Pro Gln Gln Gln Gln Gln Ala Gln Gln Val Phe Gln Phe Ile Gln 
305                 310                 315                 320 


Gly Pro Gln Gly Gln Leu Ile Ala Thr Thr Pro Gln Gln Gln Gln Pro 
                325                 330                 335     


Ile Gln Gln Gln Gln Gln Gln Gln Pro Gln Pro Val Gln Gln Gln Gln 
            340                 345                 350         


Gln His Arg Phe Val Ser Asn Ala Gly Val Thr Gly Met Ser Thr Gly 
        355                 360                 365             


Lys Thr Gly Lys Ala Pro Gln Gln Ile Leu Pro Lys Pro Gln Gln Glu 
    370                 375                 380                 


Leu Gln Gln Gln Lys Lys Gly Thr Asn Gly Gly Ala Gln Ile Ser Gln 
385                 390                 395                 400 


Ser Ala Gln Gln Thr Gly Gln Ala Asn Asn Pro Thr Gln Gln Gln Gln 
                405                 410                 415     


Gln Gln Gln Gln Gln Gln Ile Leu Leu Pro Ala Thr Thr Asn Gln Pro 
            420                 425                 430         


Gln Gln Leu Leu Leu Asn Gln Met Pro Val Leu Val Gln Gln Asn Pro 
        435                 440                 445             


Gln Gly Val Gln Leu Ile Leu Arg Pro Pro Thr Pro Gln Leu Thr Thr 
    450                 455                 460                 


Thr Pro Ser Leu Val Ile Gln Gln Asn Ala Arg Gly Gln Pro Gln Leu 
465                 470                 475                 480 


Gln Thr Gln Pro Ala Gln Gln Gln Leu Leu Arg Ile Val Gly Thr Asn 
                485                 490                 495     


Gly Ala Thr Met Gln Leu Ala Ala Ala Pro Thr Phe Ile Val Ser Ser 
            500                 505                 510         


Gln Ala Asn Leu Ile His Gln Thr Ala Ala Gly Gln Phe Gln Ser Ala 
        515                 520                 525             


Ile Lys Ser Gly Thr Gln Leu Thr Gly Leu His Ala Ala Leu Ala Gln 
    530                 535                 540                 


Ala Gln Ala Gln Ala Gln Ala Pro Arg Ser Gln Pro Phe Ala Thr Thr 
545                 550                 555                 560 


Ala Thr Leu Asn Thr Gln Leu Leu Gly Gln Ser Val Ala Ala Gln Leu 
                565                 570                 575     


Gln Asn Leu Gln Leu Ala Ala Ala Gln Ile Gln Met Pro Asn Gly Leu 
            580                 585                 590         


Thr Ala Ile Ser Gln Leu Pro Ala His Leu Gln Gln Ser Leu Gly Gly 
        595                 600                 605             


Ala Thr Ile Asn Leu Asn Gln Leu Asn Gly Ala His Ile Gln Gln Ile 
    610                 615                 620                 


Ala Asn Ala Phe Gln Ala Pro Gln Ala Pro Gly Thr Asn Ser Gly Gly 
625                 630                 635                 640 


Ala Asn Ser Thr Thr Glu Leu Phe Thr Gln Ser Ser Pro Ala His Val 
                645                 650                 655     


Pro Leu Ala Val Thr Pro Glu Pro Leu Arg Gln Pro Thr Pro Val Pro 
            660                 665                 670         


Met Met Gln Gln Gln Gln Gln Ala Ala Met Ala Thr Ile Gln Leu Gln 
        675                 680                 685             


Gln Gln Gln Gln Gln Gln Gln Gln Ala Gln Ile Gln Gln Leu Gln His 
    690                 695                 700                 


Gln Leu Gln Gln Thr Gln Ser Gln Val Gln Gln Ala Gln Gln Ser Val 
705                 710                 715                 720 


Gln Ala Thr Thr Ile Pro Glu Pro Lys Lys Lys Pro Arg Pro Arg Lys 
                725                 730                 735     


Lys Lys Gln Pro Pro Ala Pro Thr Pro Pro Ala Ala Ser Pro Thr Val 
            740                 745                 750         


Ala Pro Ala Glu Val Arg Pro Pro Thr Pro Gln Lys Ile Ala Ile Ala 
        755                 760                 765             


Ala Thr Pro Ala Pro Gln Pro Thr Val Arg Ala Lys Ser Pro Ser Pro 
    770                 775                 780                 


Pro Pro Thr Thr Ile Gln Arg Ser Ser Asn Gly Lys Leu Asp Leu Gly 
785                 790                 795                 800 


Asp Val Met Lys Phe Cys Gly Ile Thr Gly Asp Asp Asp Asp Asp Glu 
                805                 810                 815     


Asp Tyr Gly Met Gly Leu Glu Thr Gly Leu Ala Ser Glu Ser Glu Pro 
            820                 825                 830         


Ala Gln Ala His Ala Pro Ala Thr Gly Ser Ala Ala Ala Thr Thr Gly 
        835                 840                 845             


Ser Ser Gly Asp Ile Met Ile Ser Ile Pro Asn Gln Asn Gly Ser Asp 
    850                 855                 860                 


Gly Leu Pro Phe Thr Leu Thr Ile Pro Ala Pro Gln Pro Gln Ser Ser 
865                 870                 875                 880 


Thr Gly Ser Gln Ala Ala Gly Asn Glu Ser Ala Thr Glu Ile Pro Asn 
                885                 890                 895     


Ile Leu Ile Lys Ile Asp Pro Ser Ala Glu Ala Ala Val Pro Pro Phe 
            900                 905                 910         


Gly Leu Ser Thr Pro Arg Leu Pro Thr Ala Glu Glu Ile Gln Lys Gln 
        915                 920                 925             


Ala Gln Gln His Leu Ala Gln Gln Ala Ala Ala Ala Ala Ala Ala Ala 
    930                 935                 940                 


Lys Ala Thr Thr Ala Thr Pro Thr Ile Asn Ile Ser Leu Pro Ser Met 
945                 950                 955                 960 


Thr Leu Gln Pro Gln Val Ala Pro Ala Pro Val Val Thr Pro Thr Pro 
                965                 970                 975     


Ala Pro Ser Ser Asn Gln Val Ser Thr Thr Val Val Val Lys Pro Arg 
            980                 985                 990         


Arg Lys Pro Ala Val Arg Arg Asn  Ala Lys Lys Pro Asp  Val Thr Ser 
        995                 1000                 1005             


Ser Ala  Ser Asn Met Ile Ser  Ser Ser Ser Gly Thr  Thr Thr Thr 
    1010                 1015                 1020             


Ile Ser  Ser Ser Thr Ser Thr  Ile Leu Asn Asn Ser  Gln Pro Thr 
    1025                 1030                 1035             


Thr Val  Asn Thr Ile Thr Leu  Thr Thr Pro Thr Pro  Val Thr Ser 
    1040                 1045                 1050             


Ser Ser  Asn Ser Thr Leu Met  Leu Thr His Gly Thr  Pro Thr Ala 
    1055                 1060                 1065             


Val Pro  Ser Gln Ile Gly Asn  Ile Gln Ile Ser Gln  Val His Asn 
    1070                 1075                 1080             


His His  Pro Ser Ala Leu Pro  Val Ser Ser Ala Val  Glu Asn Lys 
    1085                 1090                 1095             


Ile Gln  Ile Met Pro Ile Leu  Pro Pro Gly Ala Thr  Val Met Gly 
    1100                 1105                 1110             


Gly Thr  Pro Gly Thr Gly Gly  His Ala Pro Thr Thr  Gln Ser Thr 
    1115                 1120                 1125             


Gln Leu  Val Phe Gln Pro Ala  Ala Pro Ser Val Ala  Pro Thr Ile 
    1130                 1135                 1140             


Thr Ser  Asp Ser Thr Gly Phe  Lys Leu Ser Ser Asp  Gly Arg Gln 
    1145                 1150                 1155             


Met Gln  Leu Val Ala Ile Pro  Gln Ala Thr Pro Pro  Ser Pro Ala 
    1160                 1165                 1170             


Ala Ser  Ser Ala Gln Pro Pro  Val Pro Thr Pro Thr  Pro Ala Leu 
    1175                 1180                 1185             


Thr Ala  Gly Gly Ala Thr Ile  Leu Pro Pro Gln Leu  Thr Gly Met 
    1190                 1195                 1200             


Pro Ala  Asn Val Ser Val Ser  Val Gly Ser Pro Ala  Ser Ala Ala 
    1205                 1210                 1215             


Ala Leu  Val Pro Gln Leu Thr  Gly Ser Leu Thr Leu  Thr Val Ser 
    1220                 1225                 1230             


Glu Gln  Cys Glu Arg Leu Ile  Leu Arg His Asp Pro  Asn Asn Pro 
    1235                 1240                 1245             


Gln Asp  His Gln Ser Gln Leu  Ile Leu Gln Ala Leu  Leu Lys Gly 
    1250                 1255                 1260             


Ala Leu  Pro Asn Val Thr Ile  Ile Asn Glu Pro Thr  Arg Val Asp 
    1265                 1270                 1275             


Pro Asn  Lys Gln Thr Thr Pro  Met Leu Gln Pro Gln  Gln Gln Val 
    1280                 1285                 1290             


Ile Gln  Ile Pro Gln Pro Leu  Thr Gln Pro Gln Gln  Ile Leu Gln 
    1295                 1300                 1305             


Gln Gln  Pro Lys Val Ser Thr  Ala Pro Lys Ile Glu  Val Lys Val 
    1310                 1315                 1320             


Ala Asn  Asn Arg Lys Leu Ser  Gly Gln Val Thr His  Pro Ala Ser 
    1325                 1330                 1335             


Ser Met  Leu Gly Met Thr Ser  Thr Thr Thr Thr Met  Ser Thr Met 
    1340                 1345                 1350             


Lys Pro  Pro Ala Asn Leu Pro  Ala Lys Gln Asn Glu  Val Val Ser 
    1355                 1360                 1365             


Phe Pro  Gln Leu Pro Leu Asn  Ser Gln Val Leu Ile  Gln Gln Gln 
    1370                 1375                 1380             


Pro Met  Ile Ser Ala Gln Leu  Gln Pro Gln Leu Gln  Pro Val Thr 
    1385                 1390                 1395             


Val Pro  Val Ser Leu Pro Thr  Gln Pro Val Pro Ile  Pro Ser Pro 
    1400                 1405                 1410             


Ala Pro  Ala Pro Gln Leu Ala  Asn Asn Gly Gln Gln  Arg Tyr Ile 
    1415                 1420                 1425             


Ala Leu  Pro Pro Ile Asp Pro  Thr Thr Gln Gln Leu  Phe Cys Leu 
    1430                 1435                 1440             


Asn Ser  Val Thr Asn Gln Ile  Thr Ala Met Ser Ala  Gly Gln Thr 
    1445                 1450                 1455             


Ala Ala  Ser Ile Gly Pro Thr  Glu Arg Leu Leu Ile  Ala Pro Ala 
    1460                 1465                 1470             


Gly Ile  Asn Ala Gln Gln Leu  Ala Gln Cys Leu Gln  Leu Gly Gln 
    1475                 1480                 1485             


Leu His  Phe Asn Asp Val Asn  Pro Leu Pro Ala Gln  Gln Gln Gln 
    1490                 1495                 1500             


Gln Gln  Val Ala Thr Thr Ser  Ser Ser Met Thr Leu  Ser Met Pro 
    1505                 1510                 1515             


Leu Arg  Pro Gln Pro Pro Gln  Gln Gln Ile Val His  Pro Ile Gln 
    1520                 1525                 1530             


Pro Ile  Thr Asn Gly Leu Ala  Ile Thr Thr Thr Ala  Ser Ser Thr 
    1535                 1540                 1545             


Leu Thr  Thr Thr Thr Ser Thr  Thr Ser Leu Thr Thr  Val Thr Lys 
    1550                 1555                 1560             


Gln Val  Ala Asn Val Ala Pro  Ile Ile Asp Gln Ser  Lys Ala Lys 
    1565                 1570                 1575             


Leu Glu  Pro Ala Lys Ala Ala  Thr Ser Gly Ala Gly  Gly Gly Ala 
    1580                 1585                 1590             


Val Val  Lys Lys Lys Pro Val  Arg Lys Pro Lys Ala  Thr Pro Thr 
    1595                 1600                 1605             


Asn Ala  Ser Glu Leu Ala Asn  Leu Lys Asn Ala Ser  Val Val Lys 
    1610                 1615                 1620             


Pro Met  Pro Lys Leu Asp Pro  Leu Ser Gln Lys Pro  Asn Asn Asn 
    1625                 1630                 1635             


Pro Val  Gln Ile Val Gln Pro  Asn Val Ala Ser Gly  Lys Gln Met 
    1640                 1645                 1650             


Ile Val  Val Gly Ser Ser Ser  Cys Thr Thr Thr Thr  Thr Thr Thr 
    1655                 1660                 1665             


Met Ser  Ala Ser Ile Gln Pro  Phe Gln Thr Thr Ser  Gly Thr Lys 
    1670                 1675                 1680             


Leu Val  Gly Val Thr Val Pro  Met Gln Gln Gln Gln  Pro Thr Gly 
    1685                 1690                 1695             


Thr Ala  Ala Ile Leu Gln Gln  Gln Gln Gln Gln Arg  Thr Ser Phe 
    1700                 1705                 1710             


Ser Leu  Thr Ala Thr Thr Val  Ala Thr Pro Ala Pro  Met Pro Ser 
    1715                 1720                 1725             


Pro Thr  Val Ala Ser Gly Val  Ser Gln Leu Gln Met  Gln Gln Leu 
    1730                 1735                 1740             


Pro Ser  Gln Gln Ala Gln Gln  Gln Leu Gln Pro Gln  Gln Gln Gln 
    1745                 1750                 1755             


Gln Leu  His Ala Pro Lys Gln  Gln Gln Pro Gln Pro  Asn Thr Val 
    1760                 1765                 1770             


Ser Arg  Val Gln Thr Ile Gln  Leu Thr Pro Gln Met  Gln Gln Ile 
    1775                 1780                 1785             


Phe Lys  Gln Val Gln Met Gln  Ile Gln Phe Leu Thr  Ile Lys Leu 
    1790                 1795                 1800             


Gln Asn  Lys Ser Thr Phe Leu  Pro Val Ser Pro Glu  Ile Asp Ser 
    1805                 1810                 1815             


Ala Thr  Ile Ala Ala Tyr Asn  Lys Pro Met Thr Asp  Ala Glu Ile 
    1820                 1825                 1830             


Asn Leu  Ala Leu Gln Arg Leu  Phe Ala Glu Gln His  Arg Ile Leu 
    1835                 1840                 1845             


Ala Ser  Gly Lys Glu Val Pro  Thr Pro Glu Gly Met  Leu Pro Thr 
    1850                 1855                 1860             


Ala Asn  Gly Thr Gly Gly Phe  Ser Leu Met Pro Gln  Pro Val Gln 
    1865                 1870                 1875             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Leu Gln Ser  Thr Val Pro 
    1880                 1885                 1890             


Glu Pro  Leu Lys Thr Ile Val  Pro Ala Asn Val Val  Gln Pro Asn 
    1895                 1900                 1905             


Asn His  Ser Ser Thr Pro Ala  Gly Ala Ala Thr Ser  Gly Ala Thr 
    1910                 1915                 1920             


Thr Ala  Ala Asn Ile Gln Gln  Asn Ile Thr Gln Arg  Ile His Ile 
    1925                 1930                 1935             


Tyr Pro  Met Gln His Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1940                 1945                 1950             


Gln Gln  Gln Gln Pro Gln His  Gln Gln Gln Gln Pro  Gln His Gln 
    1955                 1960                 1965             


Leu Gln  Gln Thr Gly Ala Lys  Pro Lys Gln Ala Gln  Pro Lys Pro 
    1970                 1975                 1980             


Pro Pro  Gln Gln Glu Gln Gln  Ser Gln Leu Gln Ile  Lys Pro Lys 
    1985                 1990                 1995             


Glu Pro  Ala Asn Arg Ser Lys  Val Thr Ser Gln Gln  Leu Gln Gln 
    2000                 2005                 2010             


Asn Pro  Gln Pro Pro Asn Gly  Thr Ile Asn Met Leu  Pro Gln Lys 
    2015                 2020                 2025             


Val Ser  Met Met Pro Val Val  Gln Gln Gln Gln Gln  Gln Gln Pro 
    2030                 2035                 2040             


Gln Gln  His Gln Gln Gln Pro  Met Leu Asn Lys Ser  Gly Pro Pro 
    2045                 2050                 2055             


Pro Leu  Ile Phe Ala Ser Ser  Thr Asn Met Leu Ser  Asn Ser Asn 
    2060                 2065                 2070             


Ser Asn  Asn Leu His Asn Ser  Asn Ser Ala Met Gln  Val Asn Asn 
    2075                 2080                 2085             


Met Leu  Pro Leu Pro Pro Leu  Gln Pro Gln Gln Gln  Pro Gln Pro 
    2090                 2095                 2100             


Gln Leu  Gln Gln Pro Pro Thr  Pro Ile Leu Pro Pro  Val Ala Pro 
    2105                 2110                 2115             


Thr Met  Ala Met Gly Val Ala  Pro Gly Pro Met Gly  Asn Leu Val 
    2120                 2125                 2130             


Pro Ser  Leu Pro Thr Ile Pro  Ser Leu Pro Leu Tyr  Met Pro Ser 
    2135                 2140                 2145             


Lys Met  Asp Glu Met Pro Thr  Gln Lys Pro Lys Ile  Ala Arg Leu 
    2150                 2155                 2160             


Ser Leu  Phe Val Arg Gln Leu  Glu Val Asp Gln Glu  Ser Cys Leu 
    2165                 2170                 2175             


Lys Pro  Asp Tyr Val Lys Pro  Phe Arg Thr Lys Asp  Glu Ala Val 
    2180                 2185                 2190             


Lys Arg  Leu Ile Arg Tyr His  Cys Met His Glu Asn  Asp Val Glu 
    2195                 2200                 2205             


Leu Pro  Ser Asp Glu Asp Glu  Glu Phe Glu Ser Thr  Ala Leu Glu 
    2210                 2215                 2220             


Phe Gln  Asp Lys Phe Arg Gln  Leu Asn Gly Lys Phe  Gln Glu Ile 
    2225                 2230                 2235             


Leu Met  Gln Glu Ser Thr Leu  Pro His Arg Thr Ser  Glu Leu Leu 
    2240                 2245                 2250             


Gln Met  Gln Gln Leu Met Ile  Asp Asp Leu Lys Gly  Glu Ile Asn 
    2255                 2260                 2265             


Glu Ile  Arg Thr Ala Glu Lys  Glu Leu Glu Gln Gln  Leu Lys Glu 
    2270                 2275                 2280             


Glu Gln  Thr Ser Glu Lys Ser  Thr Ala Glu Ser Asp  Val Leu Ser 
    2285                 2290                 2295             


Glu Ala  Lys Val Lys Glu Glu  Ile Lys Gln Glu Pro  Ile Asp Lys 
    2300                 2305                 2310             


Ser Ala  Gln Pro Asp Gly Val  Val Asp Lys Phe Asp  Leu Leu Lys 
    2315                 2320                 2325             


Asn Ser  Ala Asp Val Asn Lys  Ala Phe Ser Lys Ser  Gln Pro Gln 
    2330                 2335                 2340             


Gln Thr  Thr Thr Val Lys Gln  Glu Glu Ser Asn Glu  Ser Gly Glu 
    2345                 2350                 2355             


Pro Ser  Val Asn Gly Ser Val  Lys Ser Glu Gly His  Asp Lys Glu 
    2360                 2365                 2370             


Ser Ser  Lys Tyr Ile Lys Lys  Asp Tyr Asp Asn Phe  Asp Ile Glu 
    2375                 2380                 2385             


Ser Glu  Leu Thr Thr Ser Phe  Ile Met Lys Lys Val  Glu Asn Lys 
    2390                 2395                 2400             


Ala Ala  Leu Ala Lys Ser Ala  Glu Asn Arg Tyr Gln  Glu Arg Asn 
    2405                 2410                 2415             


Met Met  Asp Gln Gln Gln Gln  Gln Gln His Ile Lys  Ala Asn Gly 
    2420                 2425                 2430             


Gly Asp  Pro Val Asp Gln Asp  Asp Gly Trp Tyr Cys  Leu Gln Lys 
    2435                 2440                 2445             


Glu Leu  Asn Leu Met Asn Asn  Asp His Met Gln Gln  Ser Gln Gln 
    2450                 2455                 2460             


Gln Leu  Asn Gly Asn Gln Gln  His Leu Pro Ile Asn  Arg Gln Pro 
    2465                 2470                 2475             


Ala Pro  Gln Gln Ser His Phe  Leu Asp Asn Ser Asn  Ser Asn Asn 
    2480                 2485                 2490             


Met Met  Gly Asn Ser Asn His  Met Ser Asp Leu Phe  Pro Asn Gly 
    2495                 2500                 2505             


Cys Ile  Asp Lys Ser Asn Gln  Ser Thr Thr Ser Ser  Ser Asn Ser 
    2510                 2515                 2520             


Ser Cys  Val Ser Glu Ser Leu  Pro Gly Ser Asn Pro  Val Lys Thr 
    2525                 2530                 2535             


Val Ser  Ser Cys Ser Gly Gln  Arg Glu Gln Pro Val  Val Met Asp 
    2540                 2545                 2550             


Ala Asp  Gln Gln Asn Glu His  Pro Ala Ile Ser Glu  Phe Phe Ser 
    2555                 2560                 2565             


Ser Asp  Ser Asp Val Gln Lys  Ser Val Glu Thr Arg  Leu Glu Ala 
    2570                 2575                 2580             


Met Phe  Gly Glu Ser Pro Val  His Leu Asp Val Lys  Ser Ser Asn 
    2585                 2590                 2595             


Asp Ala  Asn Asp Ile Glu Ser  Asn Leu Asp Glu Ile  Phe Gly Asp 
    2600                 2605                 2610             


Ser Lys  Ser Pro Ala Ala Asn  His Lys Ser Lys Met  Ser Met Trp 
    2615                 2620                 2625             


Val Pro  Asp Ala Ser Phe Met  Gln Gln Ala Pro Gln  Gln Gln Thr 
    2630                 2635                 2640             


Ser Gln  Gln Gln Gln Gln Tyr  Ala Gly Pro Gln Gln  Pro Ser Gln 
    2645                 2650                 2655             


Gln Gln  His His Ile Glu Leu  Asn Cys Asn Asn Asn  Pro Arg Trp 
    2660                 2665                 2670             


Met Gln  Ser Met Glu Ala His  Tyr Ser Asp Phe Leu  Ser Thr Gly 
    2675                 2680                 2685             


Thr Ser  Asn Gly Glu Leu Val  Asn Gly Glu Ser Arg  Lys Arg Ser 
    2690                 2695                 2700             


Trp Asp  Ser Gln Leu Met Gly  Ser Gly Ser Asp Met  Glu Asp Asp 
    2705                 2710                 2715             


Asn Ser  Ser Lys Arg Leu Cys  Thr Ala Ser Ser Ser  Ser Ser Ser 
    2720                 2725                 2730             


Ser Pro  Met Ser Ser Gln Gln  Gln His Val Gln Val  Ala Gln His 
    2735                 2740                 2745             


Gly Leu  Leu Asp Ser Asp Met  Phe Pro Gln Met Leu  Met Asp Gln 
    2750                 2755                 2760             


Gln Pro  His Gln Gln Gln Gln  Gln Val Gln Gln Gln  His Asn Phe 
    2765                 2770                 2775             


Ala Tyr  Ala Asn Ile Met Asp  Gln Gln Gln Gln Gln  Gln His Gln 
    2780                 2785                 2790             


Gln Gln  His Phe Gln His Asn  Leu Gln Gln Gln Ile  Gln Gln Gln 
    2795                 2800                 2805             


Gln Gln  Met His Val Ser His  Met Gly Gly Ala Ala  Val Val Ala 
    2810                 2815                 2820             


Gly Gly  Glu Tyr Asp Asp Asp  Ile Ser Arg His Val  Ala Ser Ala 
    2825                 2830                 2835             


Ile Asp  Ser Ile Leu Asn Leu  Gln Asn Ser Gly Asp  Ser Leu Gln 
    2840                 2845                 2850             


Phe Ser  Leu Gly Ser Ile Leu  Gly Asp Ser Met Leu  Asp Asp Gln 
    2855                 2860                 2865             


Arg Gln  Ala Gly Ala Asn Leu  Pro Ser Cys Gln Gln  Glu Gln Ala 
    2870                 2875                 2880             


Ile Gln  Arg Arg Arg His Leu  Gly Glu Glu Met Asn  Asp Cys Leu 
    2885                 2890                 2895             


Ile Ser  Gly Gly Gly Ser Ala  Val Ser Gly Val Ala  Asp Asn Ser 
    2900                 2905                 2910             


Ser Asn  Ile Leu Leu Glu His  His His Gln Gln His  Gln Leu Met 
    2915                 2920                 2925             


Gln Ser  His Gln Gln Gln Pro  His Leu Gln His His  His His Gln 
    2930                 2935                 2940             


Asn Met  Ser Gln Ala Gln Ala  Gln His Met Gly Gln  Leu Asn Asp 
    2945                 2950                 2955             


Phe Ser  Cys Val Ala Gly Gly  Leu Asp Asp Pro Val  Lys Ser Ile 
    2960                 2965                 2970             


Met Thr  Ser Xaa Leu Gly Ala  Pro Ser Ser Thr Ser  Ala Ala Glu 
    2975                 2980                 2985             


Asn Ala  Ser Asn Ser Leu Ile  Leu Glu Phe Asn Ala  Thr Thr Leu 
    2990                 2995                 3000             


<210>  13
<211>  655
<212>  PRT
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (544)..(544)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Met Leu Thr Thr Glu His Ile Met His Gly His Pro His Ser Ser 
1               5                   10                  15      


Val Gly Gln Ser Thr Leu Phe Gly Cys Ser Thr Ala Gly His Ser Gly 
            20                  25                  30          


Ile Asn Gln Leu Gly Gly Val Tyr Val Asn Gly Arg Pro Leu Pro Asp 
        35                  40                  45              


Ser Thr Arg Gln Lys Ile Val Glu Leu Ala His Ser Gly Ala Arg Pro 
    50                  55                  60                  


Cys Asp Ile Ser Arg Ile Leu Gln Val Ser Asn Gly Cys Val Ser Lys 
65                  70                  75                  80  


Ile Leu Gly Arg Tyr Tyr Glu Thr Gly Ser Ile Lys Pro Arg Ala Ile 
                85                  90                  95      


Gly Gly Ser Lys Pro Arg Val Ala Thr Thr Pro Val Val Gln Lys Ile 
            100                 105                 110         


Ala Asp Tyr Lys Arg Glu Cys Pro Ser Ile Phe Ala Trp Glu Ile Arg 
        115                 120                 125             


Asp Arg Leu Leu Ser Glu Gln Val Cys Asn Ser Asp Asn Ile Pro Ser 
    130                 135                 140                 


Val Ser Ser Ile Asn Arg Val Leu Arg Asn Leu Ala Ser Gln Lys Glu 
145                 150                 155                 160 


Gln Gln Ala Gln Gln Gln Asn Glu Ser Val Tyr Glu Lys Leu Arg Met 
                165                 170                 175     


Phe Asn Gly Gln Thr Gly Gly Trp Ala Trp Tyr Pro Ser Asn Thr Thr 
            180                 185                 190         


Thr Ala His Leu Thr Leu Pro Pro Ala Ala Ser Val Val Thr Ser Pro 
        195                 200                 205             


Ala Asn Leu Ser Gly Gln Ala Asp Arg Asp Asp Val Gln Lys Arg Glu 
    210                 215                 220                 


Leu Gln Phe Ser Val Glu Val Ser His Thr Asn Ser His Asp Ser Thr 
225                 230                 235                 240 


Ser Asp Gly Asn Ser Glu His Asn Ser Ser Gly Asp Glu Asp Ser Gln 
                245                 250                 255     


Met Arg Leu Arg Leu Lys Arg Lys Leu Gln Arg Asn Arg Thr Ser Phe 
            260                 265                 270         


Ser Asn Glu Gln Ile Asp Ser Leu Glu Lys Glu Phe Glu Arg Thr His 
        275                 280                 285             


Tyr Pro Asp Val Phe Ala Arg Glu Arg Leu Ala Asp Lys Ile Gly Leu 
    290                 295                 300                 


Pro Glu Ala Arg Ile Gln Val Trp Phe Ser Asn Arg Arg Ala Lys Trp 
305                 310                 315                 320 


Arg Arg Glu Glu Lys Met Arg Thr Gln Arg Arg Ser Ala Asp Thr Val 
                325                 330                 335     


Asp Gly Ser Gly Arg Thr Ser Thr Ala Asn Asn Pro Ser Gly Thr Thr 
            340                 345                 350         


Ala Ser Ser Ser Val Ala Thr Ser Asn Asn Ser Thr Pro Gly Ile Val 
        355                 360                 365             


Asn Ser Ala Ile Asn Val Ala Glu Arg Thr Ser Ser Ala Leu Val Ser 
    370                 375                 380                 


Asn Ser Leu Pro Glu Ala Ser Asn Gly Pro Thr Val Leu Gly Gly Glu 
385                 390                 395                 400 


Ala Asn Thr Thr His Thr Ser Ser Glu Ser Pro Pro Leu Gln Pro Ala 
                405                 410                 415     


Ala Pro Arg Leu Pro Leu Asn Ser Gly Phe Asn Thr Met Tyr Ser Ser 
            420                 425                 430         


Ile Pro Gln Pro Ile Ala Thr Met Ala Glu Asn Tyr Asn Ser Ser Leu 
        435                 440                 445             


Gly Ser Met Thr Pro Ser Cys Leu Gln Gln Arg Asp Ala Tyr Pro Tyr 
    450                 455                 460                 


Met Phe His Asp Pro Leu Ser Leu Gly Ser Pro Tyr Val Ser Ala His 
465                 470                 475                 480 


His Arg Asn Thr Ala Cys Asn Pro Ser Ala Ala His Gln Gln Pro Pro 
                485                 490                 495     


Gln His Gly Val Tyr Thr Asn Ser Ser Pro Met Pro Ser Ser Asn Thr 
            500                 505                 510         


Gly Val Ile Ser Ala Gly Val Ser Val Pro Val Gln Ile Ser Thr Gln 
        515                 520                 525             


Asn Val Ser Asp Leu Thr Gly Ser Asn Tyr Trp Pro Arg Leu Gln Xaa 
    530                 535                 540                 


Ser Ser Ile Phe Gly Ser Pro Leu Asp His Leu Ser Lys Ala Thr Ala 
545                 550                 555                 560 


Ala Ala Ile Ile Ala Ala Gln Ala Ala Glu Lys Ser His Lys His Arg 
                565                 570                 575     


Lys Glu His Ser Ile Val Ser Ile His Thr Thr Lys Arg Lys Lys Asn 
            580                 585                 590         


Pro Pro Ser Leu Lys Arg Gln Thr Thr Cys Cys Ser Ser Arg Tyr Leu 
        595                 600                 605             


Asn Met Thr Phe Gly Ala Gly Lys Asp Val Asp Val Val Ile Gly Gln 
    610                 615                 620                 


Gly Leu Ile Val Ser Leu Thr Pro His Ile Ser Gly Lys Pro Glu Leu 
625                 630                 635                 640 


Phe Gly Ser Pro Asn Val Asn Tyr His Gln Asp Phe Gln Val Ile 
                645                 650                 655 


<210>  14
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Arg Arg Pro Arg His Ser Ile Tyr Ser Ser Asp Glu Asp Asp 
1               5                   10                  15      


Glu Asp Phe Glu Met Cys Asp His Asp Tyr Asp Gly Leu Leu Pro Lys 
            20                  25                  30          


Ser Gly Lys Arg His Leu Gly Lys Thr Arg Trp Thr Arg Glu Glu Asp 
        35                  40                  45              


Glu Lys Leu Lys Lys Leu Val Glu Gln Asn Gly Thr Asp Asp Trp Lys 
    50                  55                  60                  


Val Ile Ala Asn Tyr Leu Pro Asn Arg Thr Asp Val Gln Cys Gln His 
65                  70                  75                  80  


Arg Trp Gln Lys Val Leu Asn Pro Glu Leu Ile Lys Gly Pro Trp Thr 
                85                  90                  95      


Lys Glu Glu Asp Gln Arg Val Ile Glu Leu Val Gln Lys Tyr Gly Pro 
            100                 105                 110         


Lys Arg Trp Ser Val Ile Ala Lys His Leu Lys Gly Arg Ile Gly Lys 
        115                 120                 125             


Gln Cys Arg Glu Arg Trp His Asn His Leu Asn Pro Glu Val Lys Lys 
    130                 135                 140                 


Thr Ser Trp Thr Glu Glu Glu Asp Arg Ile Ile Tyr Gln Ala His Lys 
145                 150                 155                 160 


Arg Leu Gly Asn Arg Trp Ala Glu Ile Ala Lys Leu Leu Pro Gly Arg 
                165                 170                 175     


Thr Asp Asn Ala Ile Lys Asn His Trp Asn Ser Thr Met Arg Arg Lys 
            180                 185                 190         


Val Glu Gln Glu Gly Tyr Leu Gln Glu Ser Ser Lys Ala Ser Gln Pro 
        195                 200                 205             


Ala Val Ala Thr Ser Phe Gln Lys Asn Ser His Leu Met Gly Phe Ala 
    210                 215                 220                 


Gln Ala Pro Pro Thr Ala Gln Leu Pro Ala Thr Gly Gln Pro Thr Val 
225                 230                 235                 240 


Asn Asn Asp Tyr Ser Tyr Tyr His Ile Ser Glu Ala Gln Asn Val Ser 
                245                 250                 255     


Ser His Val Pro Tyr Pro Val Ala Leu His Val Asn Ile Val Asn Val 
            260                 265                 270         


Pro Gln Pro Ala Ala Ala Ala Ile Gln Arg His Tyr Asn Asp Glu Asp 
        275                 280                 285             


Pro Glu Lys Glu Lys Arg Ile Lys Glu Leu Glu Leu Leu Leu Met Ser 
    290                 295                 300                 


Thr Glu Asn Glu Leu Lys Gly Gln Gln Val Leu Pro Thr Gln Asn His 
305                 310                 315                 320 


Thr Cys Ser Tyr Pro Gly Trp His Ser Thr Thr Ile Ala Asp His Thr 
                325                 330                 335     


Arg Pro His Gly Asp Ser Ala Pro Val Ser Cys Leu Gly Glu His His 
            340                 345                 350         


Ser Thr Pro Ser Leu Pro Ala Asp Pro Gly Ser Leu Pro Glu Glu Ser 
        355                 360                 365             


Ala Ser Pro Ala Arg Cys Met Ile Val His Gln Gly Thr Ile Leu Asp 
    370                 375                 380                 


Asn Val Lys Asn Leu Leu Glu Phe Ala Glu Thr Leu Gln Phe Ile Asp 
385                 390                 395                 400 


Ser Asp Ser Ser Ser Trp Cys Asp Leu Ser Ser Phe Glu Phe Phe Glu 
                405                 410                 415     


Glu Ala Asp Phe Ser Pro Ser Gln His His Thr Gly Lys Ala Leu Gln 
            420                 425                 430         


Leu Gln Gln Arg Glu Gly Asn Gly Thr Lys Pro Ala Gly Glu Pro Ser 
        435                 440                 445             


Pro Arg Val Asn Lys Arg Met Leu Ser Glu Ser Ser Leu Asp Pro Pro 
    450                 455                 460                 


Lys Val Leu Pro Pro Ala Arg His Ser Thr Ile Pro Leu Val Ile Leu 
465                 470                 475                 480 


Arg Lys Lys Arg Gly Gln Ala Ser Pro Leu Ala Thr Gly Asp Cys Ser 
                485                 490                 495     


Ser Phe Ile Phe Ala Asp Val Ser Ser Ser Thr Pro Lys Arg Ser Pro 
            500                 505                 510         


Val Lys Ser Leu Pro Phe Ser Pro Ser Gln Phe Leu Asn Thr Ser Ser 
        515                 520                 525             


Asn His Glu Asn Ser Asp Leu Glu Met Pro Ser Leu Thr Ser Thr Pro 
    530                 535                 540                 


Leu Ile Gly His Lys Leu Thr Val Thr Thr Pro Phe His Arg Asp Gln 
545                 550                 555                 560 


Thr Val Lys Thr Gln Lys Glu Asn Thr Val Phe Arg Thr Pro Ala Ile 
                565                 570                 575     


Lys Arg Ser Ile Leu Glu Ser Ser Pro Arg Thr Pro Thr Pro Phe Lys 
            580                 585                 590         


His Ala Leu Ala Ala Gln Glu Ile Lys Tyr Gly Pro Leu Lys Met Leu 
        595                 600                 605             


Pro Gln Thr Pro Ser His Leu Val Glu Asp Leu Gln Asp Val Ile Lys 
    610                 615                 620                 


Gln Glu Ser Asp Glu Ser Gly Ile Val Ala Glu Phe Gln Glu Asn Gly 
625                 630                 635                 640 


Pro Pro Leu Leu Lys Lys Ile Lys Gln Glu Val Glu Ser Pro Thr Asp 
                645                 650                 655     


Lys Ser Gly Asn Phe Phe Cys Ser His His Trp Glu Gly Asp Ser Leu 
            660                 665                 670         


Asn Thr Gln Leu Phe Thr Gln Thr Ser Pro Val Ala Asp Ala Pro Asn 
        675                 680                 685             


Ile Leu Thr Ser Ser Val Leu Met Ala Pro Ala Ser Glu Asp Glu Asp 
    690                 695                 700                 


Asn Val Leu Lys Ala Phe Thr Val Pro Lys Asn Arg Ser Leu Ala Ser 
705                 710                 715                 720 


Pro Leu Gln Pro Cys Ser Ser Thr Trp Glu Pro Ala Ser Cys Gly Lys 
                725                 730                 735     


Met Glu Glu Gln Met Thr Ser Ser Ser Gln Ala Arg Lys Tyr Val Asn 
            740                 745                 750         


Ala Phe Ser Ala Arg Thr Leu Val Met 
        755                 760     


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEP


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Arg is L-Arg or D-Arg

<400>  15

His His His Arg Leu Ser His 
1               5           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT PTD

<400>  16

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD

<400>  17

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  poly-Arg

<400>  18

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD-5

<400>  19

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  20
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transportan

<400>  20

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KALA

<400>  21

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu Ala 
            20                  25                  


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTD

<400>  22

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SV 40 T antigen

<400>  23

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  24

Gly Lys Lys Arg Ser Lys Val 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  25

Lys Ser Arg Lys Arg Lys Leu 
1               5           


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  26

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Asp Lys 
            


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  27

Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp Lys Ala 
1               5                   10                  15      


Lys Lys Ser Lys 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  28

Lys Asp Cys Val Met Asn Lys His His Arg Asn Arg Cys Gln Tyr Cys 
1               5                   10                  15      


Arg Leu Gln Arg 
            20  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  29

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  30

Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pax6 Sequence 1

<400>  31
ccacttcaac aggactcatt t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pax6 Sequence 2

<400>  32
gcaagaatac aggtatggtt t                                                 21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Pax6 siRNA1 Forward

<400>  33
ggcaaucggu gguaguaaat t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Pax6 siRNA1 Reverse

<400>  34
uuuacuacca ccgauugccc t                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Pax6 siRNA2 Forward

<400>  35
caagcguguc aucaauaaat t                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Pax6 siRNA2 Reverse

<400>  36
uuuauugaug acacgcuugg t                                                 21


