                         б

<110>  ϺʫƼ޹˾
       ŵƼ޹˾
 
<120>  һʶBAFF-RǶϿԭӼӦ

<130>  TFF00629PCT

<150>  PCT/CN2021/094605
<151>  2021-05-19

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  63
<212>  DNA
<213>  ˹

<220>
<223>  CD8źı

<400>  1
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccc                                                                     63


<210>  2
<211>  21
<212>  PRT
<213>  ˹

<220>
<223>  CD8ź

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  3
<211>  738
<212>  DNA
<213>  ˹

<220>
<223>  scFv

<400>  3
gacatccaga tgacacagag ccctgatagc ctggccgtgt ctctgggaga gagagccacc       60

atcaactgca agagcagcca gagcgtgctg tactccagca acaacaagaa ctacctggcc      120

tggtatcagc agaagcccgg ccagcctcct aagctgctga tctactgggc cagcatcaga      180

gaaagcggcg tgcccgatag attttccggc tctggcagcg gcaccgactt caccctgacc      240

atatctagcc tgcagcctga ggacttcgcc acctactact gccagcagag ctacagcacc      300

ccttggacat ttggccaggg caccaagctg gaaatcaagg gaggcggagg ttctggcggc      360

ggaggaagtg gtggcggagg ctctgaggtt cagctgcaag agtctggccc tggcctggtc      420

aagcctagcc aaacactgag cctgacctgt accgtgtccg gcgatagcat cacaagcggc      480

tactggaact ggatcagaca gcaccctggc aagggcctcg agtacatcgg ctacatcagc      540

tacagcggca gcacctacta caaccccagc ctgaagtcca gagtgaccat cagcagagac      600

accagcaaga accagtactc cctgaagctg agcagcgtga cagccgccga tacagccgtg      660

tactactgcg cctctcctaa ctaccccttc tacgccatgg actactgggg ccagggaacc      720

ctggttaccg ttagctct                                                    738


<210>  4
<211>  246
<212>  PRT
<213>  ˹

<220>
<223>  scFv

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
    130                 135                 140                 


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
                165                 170                 175     


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
            180                 185                 190         


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
        195                 200                 205             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Pro Asn Tyr Pro Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  5
<211>  118
<212>  PRT
<213>  ˹

<220>
<223>  VH

<400>  5

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Pro Asn Tyr Pro Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  6
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR H1

<400>  6

Ser Gly Tyr Trp Asn 
1               5   


<210>  7
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CDR H2

<400>  7

Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  8
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  CDR H3

<400>  8

Pro Asn Tyr Pro Phe Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  9
<211>  113
<212>  PRT
<213>  ˹

<220>
<223>  VL

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Ser Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  10
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR L1

<400>  10

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  7
<212>  PRT
<213>  ˹

<220>
<223>  CDR L2

<400>  11

Trp Ala Ser Ile Arg Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  CDR L3

<400>  12

Gln Gln Ser Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  13
<211>  135
<212>  DNA
<213>  ˹

<220>
<223>  CD8 

<400>  13
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaagcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  14
<211>  45
<212>  PRT
<213>  ˹

<220>
<223>  CD8

<400>  14

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  15
<211>  72
<212>  DNA
<213>  ˹

<220>
<223>  CD8 TM

<400>  15
atctacattt gggcccctct ggctggtact tgcggggtcc tgctgctttc actcgtgatc       60

actctttact gt                                                           72


<210>  16
<211>  24
<212>  PRT
<213>  ˹

<220>
<223>  CD8 TM

<400>  16

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  17
<211>  126
<212>  DNA
<213>  ˹

<220>
<223>  4-1BB

<400>  17
aagcgcggtc ggaagaagct gctgtacatc tttaagcaac ccttcatgag gcctgtgcag       60

actactcaag aggaggacgg ctgttcatgc cggttcccag aggaggagga aggcggctgc      120

gaactg                                                                 126


<210>  18
<211>  42
<212>  PRT
<213>  ˹

<220>
<223>  4-1BB

<400>  18

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  19
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  CD3ƷӰ

<400>  19
cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc       60

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga      120

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac      180

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc      240

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc      300

tatgacgctc ttcacatgca ggccctgccg cctcgg                                336


<210>  20
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  CD3ƷӰ

<400>  20

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  21
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  LTR-F

<400>  21
tgacagccgc ctagcatttc                                                   20


<210>  22
<211>  24
<212>  DNA
<213>  ˹

<220>
<223>  LTR-R

<400>  22
gctcgatatc agcagttctt gaag                                              24


<210>  23
<211>  22
<212>  DNA
<213>  ˹

<220>
<223>  LTR ̽

<400>  23
cacgtggccc gagagctgca tc                                                22


<210>  24
<211>  22
<212>  DNA
<213>  ˹

<220>
<223>  ALB-F

<400>  24
gctgtcatct cttgtgggct gt                                                22


<210>  25
<211>  21
<212>  DNA
<213>  ˹

<220>
<223>  ALB-R

<400>  25
actcatggga gctgctggtt c                                                 21


<210>  26
<211>  26
<212>  DNA
<213>  ˹

<220>
<223>  ALB̽

<400>  26
cctgtcatgc ccacacaaat ctctcc                                            26


