                         SEQUENCE LISTING

<110>  BeiGene, Ltd.
 
<120>  ANTI-CEA ANTIBODIES AND METHODS OF USE

<130>  1

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR1 (IMGT)

<400>  1

Gly Tyr Ile Phe Thr Ser Tyr Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR2 (IMGT)

<400>  2

Ile Asn Pro Gln Thr Gly Lys Thr 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR3 (IMGT)

<400>  3

Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr 
1               5                   10              


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR1 (IMGT)

<400>  4

Glu Asn Gln Tyr Gly Tyr 
1               5       


<210>  5
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR2 (IMGT)

<400>  5

Asn Tyr 
1       


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR3 (IMGT)/LCDR3 (Kabat)/LCDR3 (Chothia)

<400>  6

Gln His His Leu Gly Thr Pro Tyr Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR1 (Kabat)

<400>  7

Ser Tyr Tyr Leu His 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR2 (Kabat)

<400>  8

Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR3 (Kabat)/HCDR3 (Chothia)

<400>  9

Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR1 (Kabat)/LCDR1 (Chothia)

<400>  10

Arg Ala Ser Glu Asn Gln Tyr Gly Tyr Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K LCDR2 (Kabat)/LCDR2 (Chothia)

<400>  11

Asn Tyr Lys Asn Leu Val Glu 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR1 (Chothia)

<400>  12

Gly Tyr Ile Phe Thr Ser Tyr 
1               5           


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K HCDR2 (Chothia)

<400>  13

Asn Pro Gln Thr Gly Lys 
1               5       


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K VH

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Lys Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113K VL/BGA113 VL

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Tyr Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  16
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA113K VH DNA

<400>  16
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcaa gaccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360


<210>  17
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA113K VL DNA/BGA113 VL DNA

<400>  17
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcga aaaccagtat ggctatctgg cgtggtatca gcagaaaccg      120

ggcaaagtgc cgaaactgct gatttataac tataaaaacc tggtggaagg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagatgtgg cgacctatta ttgccagcat catctgggca ccccgtatac ctttggccag      300

ggcaccaaag tggaaattaa a                                                321


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR1 (IMGT)

<400>  18

Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR2 (IMGT)

<400>  19

Ile Ser Ile Gly Ser Asp Ile Ile 
1               5               


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR3 (IMGT)

<400>  20

Thr Arg Arg Ser Tyr Arg Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR1 (IMGT)

<400>  21

Glu Asn Ile Tyr Ser Tyr 
1               5       


<210>  22
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR2 (IMGT)

<400>  22

Asn Ala 
1       


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR3 (IMGT)/LCDR3 (Kabat)/LCDR3 (Chothia)

<400>  23

Gln His His Phe Leu Ser Pro Trp Met 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR1 (Kabat)

<400>  24

Ser Phe Gly Met His 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR2 (Kabat)

<400>  25

Tyr Ile Ser Ile Gly Ser Asp Ile Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR3 (Kabat)/HCDR3 (Chothia)

<400>  26

Arg Ser Tyr Arg Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR1 (Kabat)/LCDR1 (Chothia)

<400>  27

Arg Thr Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 LCDR2 (Kabat)/LCDR2 (Chothia)

<400>  28

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR1 (Chothia)

<400>  29

Gly Phe Thr Phe Ser Ser Phe 
1               5           


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 HCDR2 (Chothia)

<400>  30

Ser Ile Gly Ser Asp Ile 
1               5       


<210>  31
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190  VH

<400>  31

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Glu Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ile Gly Ser Asp Ile Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Ser Tyr Arg Ser Tyr Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA190 VL

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Ile Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Phe Leu Ser Pro Trp 
                85                  90                  95      


Met Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  33
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA190 VH DNA

<400>  33
gatgtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc ccgggaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaggg ggctggagtg ggtcgcatac attagtattg gcagtgatat catctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga ccagtctgag gtctgaggac acggccgtgt attactgtac aagaaggtct      300

tataggtcct actggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360


<210>  34
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA190 VL DNA

<400>  34
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaacaagtga gaatatttac agttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcatctcct ggtctataat gcaaaaacct tagcagaggg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcatcag cctgcagcct      240

gaagattttg ggacttatta ctgtcagcat cattttctta gtccgtggat gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR1 (IMGT)

<400>  35

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR2 (IMGT)

<400>  36

Ile Gly Pro Asn Tyr Gly Gly Thr 
1               5               


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR3 (IMGT)

<400>  37

Ala Arg Arg Gly Ser Ile Pro Arg Ala Val Asp Tyr 
1               5                   10          


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR1 (IMGT)

<400>  38

Gln Asp Ile His Asn Tyr 
1               5       


<210>  39
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR2 (IMGT)

<400>  39

Arg Ala 
1       


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR3 (IMGT)/LCDR3 (Kabat)/LCDR3 (Chothia)

<400>  40

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR1 (Kabat)

<400>  41

Asp Tyr Asn Ile Asp 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR2 (Kabat)

<400>  42

Asp Ile Gly Pro Asn Tyr Gly Gly Thr Ile Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR3 (Kabat)/HCDR3 (Chothia)

<400>  43

Arg Gly Ser Ile Pro Arg Ala Val Asp Tyr 
1               5                   10  


<210>  44
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR1 (Kabat)/LCDR1 (Chothia)

<400>  44

Lys Ala Ser Gln Asp Ile His Asn Tyr Leu Ser 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 LCDR2 (Kabat)/LCDR2 (Chothia)

<400>  45

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR1 (Chothia)

<400>  46

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 HCDR2 (Chothia)

<400>  47

Gly Pro Asn Tyr Gly Gly 
1               5       


<210>  48
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 VH

<400>  48

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Ile Asp Trp Val Gln Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Gly Pro Asn Tyr Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Ala Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Ser Ile Pro Arg Ala Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA288 VL

<400>  49

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  50
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA288 VH DNA

<400>  50
gaggtcctgc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagatt       60

ttctgtaagg cttctggata cacattcact gactacaaca tagactgggt gcagcagagc      120

catggaaaga gccttgagtg gattggagat attggtccta attatggtgg tactatctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagcca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac actgcagtct attactgtgc aagacgcggt      300

agcatcccga gggctgtgga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  51
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA288 VL DNA

<400>  51
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattcat aactatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  52
<211>  702
<212>  PRT
<213>  Homo sapiens

<220>
<223>  full-length human CEA 

<400>  52

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  53
<211>  705
<212>  PRT
<213>  Macaca mulatta

<220>
<223>  Macaca CEA  

<400>  53

Met Gly Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Thr Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Val Ser Gln Asn Leu Phe Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Glu Arg Val Asp Ala Ser Arg Arg Ile Gly 
65                  70                  75                  80  


Ser Cys Val Ile Arg Thr Gln Gln Ile Thr Pro Gly Pro Ala His Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Asp Phe Asn Ala Ser Leu Leu Ile His Asn Val 
            100                 105                 110         


Thr Gln Ser Asp Thr Gly Ser Tyr Thr Ile Gln Val Ile Lys Glu Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Glu 
            180                 185                 190         


Leu Ser Ser Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro Arg Asn 
        195                 200                 205             


Asp Thr Thr Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Val Arg 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Thr Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Phe Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Leu Pro Lys Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Ile Glu 
                325                 330                 335     


Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser Ser Arg 
        355                 360                 365             


Leu Glu Leu Ser Asn Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro 
    370                 375                 380                 


Arg Asn Asp Thr Thr Phe Tyr Glu Cys Glu Thr Gln Asn Pro Val Ser 
385                 390                 395                 400 


Val Arg Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Ala Pro Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn 
            420                 425                 430         


Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Ala Ala Gln Tyr Ser 
        435                 440                 445             


Trp Phe Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His 
465                 470                 475                 480 


Asn Ser Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val 
                485                 490                 495     


Tyr Val Glu Leu Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro 
            500                 505                 510         


Ile Glu Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Val Ala Glu 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Ile Leu Thr Leu Leu Ser 
545                 550                 555                 560 


Val Thr Arg Asn Asp Thr Gly Pro Tyr Glu Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Glu Ser Ala Lys Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Leu Ser Tyr Arg Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Asp Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Leu Ile Asn Gly Thr Leu Arg Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ser Lys Ile Thr Ser Asn Asn Ser Gly Ala Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Asn Ile 
            660                 665                 670         


Ser Val Ser Ser Gly Asp Ser Ala Pro Gly Ser Ser Gly Leu Ser Ala 
        675                 680                 685             


Arg Ala Thr Val Gly Ile Ile Ile Gly Met Leu Val Gly Val Ala Leu 
    690                 695                 700                 


Met 
705 


<210>  54
<211>  344
<212>  PRT
<213>  Homo sapiens

<220>
<223>full-length human CEACAM6 

<400>  54

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  55
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-687 of huCEA

<400>  55

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala His 
        675                 680                 685             


His His His His His 
    690             


<210>  56
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-690 of monkey CEA

<400>  56

Met Gly Ser Pro Ser Ala Pro Leu His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Thr Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Val Ser Gln Asn Leu Phe Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Glu Arg Val Asp Ala Ser Arg Arg Ile Gly 
65                  70                  75                  80  


Ser Cys Val Ile Arg Thr Gln Gln Ile Thr Pro Gly Pro Ala His Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Asp Phe Asn Ala Ser Leu Leu Ile His Asn Val 
            100                 105                 110         


Thr Gln Ser Asp Thr Gly Ser Tyr Thr Ile Gln Val Ile Lys Glu Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Glu 
            180                 185                 190         


Leu Ser Ser Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro Arg Asn 
        195                 200                 205             


Asp Thr Thr Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Val Arg 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Thr Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Phe Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Leu Pro Lys Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Ile Glu 
                325                 330                 335     


Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Glu Thr Gln Asp Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser Ser Arg 
        355                 360                 365             


Leu Glu Leu Ser Asn Asp Asn Arg Thr Leu Thr Val Phe Asn Ile Pro 
    370                 375                 380                 


Arg Asn Asp Thr Thr Phe Tyr Glu Cys Glu Thr Gln Asn Pro Val Ser 
385                 390                 395                 400 


Val Arg Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Ala Pro Thr Ile Ser Pro Leu Asn Thr Pro Tyr Arg Ala Gly Glu Asn 
            420                 425                 430         


Leu Asn Leu Ser Cys His Ala Ala Ser Asn Pro Ala Ala Gln Tyr Ser 
        435                 440                 445             


Trp Phe Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Pro Asn Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His 
465                 470                 475                 480 


Asn Ser Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Ala Ile Thr Val 
                485                 490                 495     


Tyr Val Glu Leu Pro Lys Pro Tyr Ile Ser Ser Asn Asn Ser Asn Pro 
            500                 505                 510         


Ile Glu Asp Lys Asp Ala Val Thr Leu Thr Cys Glu Pro Val Ala Glu 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Ser Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Ile Leu Thr Leu Leu Ser 
545                 550                 555                 560 


Val Thr Arg Asn Asp Thr Gly Pro Tyr Glu Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Glu Ser Ala Lys Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Leu Ser Tyr Arg Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Asp Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Leu Ile Asn Gly Thr Leu Arg Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ser Lys Ile Thr Ser Asn Asn Ser Gly Ala Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Asn Ile 
            660                 665                 670         


Ser Val Ser Ser Gly Asp Ser Ala Pro Gly Ser Ser Gly Leu Ser Ala 
        675                 680                 685             


Arg Ala His His His His His His 
    690                 695     


<210>  57
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-320 of CEACAM6

<400>  57

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


His His His His His His 
                325     


<210>  58
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-78 of huCEA

<400>  58

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn 
        115 


<210>  59
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  398-687 of huCEA

<400>  59

Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr 
1               5                   10                  15      


Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro 
            20                  25                  30          


Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala 
        35                  40                  45              


Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu 
    50                  55                  60                  


Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys 
65                  70                  75                  80  


Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr 
                85                  90                  95      


Ile Thr Val Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn 
            100                 105                 110         


Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro 
        115                 120                 125             


Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu 
    130                 135                 140                 


Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr 
145                 150                 155                 160 


Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile 
                165                 170                 175     


Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val 
            180                 185                 190         


Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr 
        195                 200                 205             


Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro 
    210                 215                 220                 


Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr 
225                 230                 235                 240 


Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr 
                245                 250                 255     


Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val 
            260                 265                 270         


Lys Ser Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala 
        275                 280                 285             


Gly Ala 
    290 


<210>  60
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA-v

<400>  60

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn 
        115                 120                 125             


Val Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr 
    130                 135                 140                 


Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn 
145                 150                 155                 160 


Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His 
                165                 170                 175     


Thr Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu 
            180                 185                 190         


Tyr Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr 
        195                 200                 205             


Val Lys Thr Ile Thr Val Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser 
    210                 215                 220                 


Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe Thr 
225                 230                 235                 240 


Cys Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly 
                245                 250                 255     


Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg 
            260                 265                 270         


Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val 
        275                 280                 285             


Cys Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr 
    290                 295                 300                 


Leu Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp 
305                 310                 315                 320 


Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser Cys His Ser Ala 
                325                 330                 335     


Ser Asn Pro Ser Pro Gln Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln 
            340                 345                 350         


Gln His Thr Gln Val Leu Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn 
        355                 360                 365             


Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn 
    370                 375                 380                 


Ser Ile Val Lys Ser Ile Thr Val Ser Ala Ser Gly Thr Ser Pro Gly 
385                 390                 395                 400 


Leu Ser Ala Gly Ala His His His His His His 
                405                 410     


<210>  61
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-273 of CEACAM6

<400>  61

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser 
            


<210>  62
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  596-687 of huCEA

<400>  62

Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu 
1               5                   10                  15      


Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp 
            20                  25                  30          


Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile Ala 
        35                  40                  45              


Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn 
    50                  55                  60                  


Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val Ser 
65                  70                  75                  80  


Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala 
                85                  90          


<210>  63
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIM

<400>  63

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
                245                 250                 255     


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
            260                 265                 270         


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
        275                 280                 285             


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
    290                 295                 300                 


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
305                 310                 315                 320 


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala His 
                325                 330                 335     


His His His His His 
            340     


<210>  64
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM1

<400>  64

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Ser Ser Gly Pro Leu Gln 
    450                 455                 460                 


<210>  65
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM3

<400>  65

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 
    130                 135                 140                 


Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln 
            180                 185                 190         


Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe 
        195                 200                 205             


Ser Met Ser Pro Leu Ser Thr Ala Gln Ala Pro Leu Pro Asn Pro Arg 
    210                 215                 220                 


Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile 
225                 230                 235                 240 


Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser 
                245                 250         


<210>  66
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM7

<400>  66

Met Gly Ser Pro Ser Ala Cys Pro Tyr Arg Val Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Leu Pro Asn 
            20                  25                  30          


Ser Ala Gln Thr Asn Ile Asp Val Val Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Val Val His Asn Glu Ser Gln Asn Leu Tyr Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Arg Val His Ala Asn Tyr Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Lys Asn Ile Ser Gln Glu Asn Ala Pro Gly Pro Ala His 
                85                  90                  95      


Asn Gly Arg Glu Thr Ile Tyr Pro Asn Gly Thr Leu Leu Ile Gln Asn 
            100                 105                 110         


Val Thr His Asn Asp Ala Gly Ile Tyr Thr Leu His Val Ile Lys Glu 
        115                 120                 125             


Asn Leu Val Asn Glu Glu Val Thr Arg Gln Phe Tyr Val Phe Ser Glu 
    130                 135                 140                 


Pro Pro Lys Pro Ser Ile Thr Ser Asn Asn Phe Asn Pro Val Glu Asn 
145                 150                 155                 160 


Lys Asp Ile Val Val Leu Thr Cys Gln Pro Glu Thr Gln Asn Thr Thr 
                165                 170                 175     


Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Leu Val Ser Pro Arg Leu 
            180                 185                 190         


Leu Leu Ser Thr Asp Asn Arg Thr Leu Val Leu Leu Ser Ala Thr Lys 
        195                 200                 205             


Asn Asp Ile Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Gly Ala 
    210                 215                 220                 


Ser Arg Ser Asp Pro Val Thr Leu Asn Val Arg Tyr Glu Ser Val Gln 
225                 230                 235                 240 


Ala Ser Ser Pro Asp Leu Ser Ala Gly Thr Ala Val Ser Ile Met Ile 
                245                 250                 255     


Gly Val Leu Ala Gly Met Ala Leu Ile 
            260                 265 


<210>  67
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEACAM8

<400>  67

Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val 
            100                 105                 110         


Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn 
        115                 120                 125             


Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser 
    290                 295                 300                 


Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp 
305                 310                 315                 320 


Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val 
                325                 330                 335     


Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile 
            340                 345                 


<210>  68
<211>  2109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full-length human CEA DNA

<400>  68
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgacac aggattctac      360

accctacacg tcataaagtc agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaacccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag actcaggacg caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa caggaccctc      600

actctattca atgtcacaag aaatgacaca gcaagctaca aatgtgaaac ccagaaccca      660

gtgagtgcca ggcgcagtga ttcagtcatc ctgaatgtcc tctatggccc ggatgccccc      720

accatttccc ctctaaacac atcttacaga tcaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttgtca atgggacttt ccagcaatcc      840

acccaagagc tctttatccc caacatcact gtgaataata gtggatccta tacgtgccaa      900

gcccataact cagacactgg cctcaatagg accacagtca cgacgatcac agtctatgca      960

gagccaccca aacccttcat caccagcaac aactccaacc ccgtggagga tgaggatgct     1020

gtagccttaa cctgtgaacc tgagattcag aacacaacct acctgtggtg ggtaaataat     1080

cagagcctcc cggtcagtcc caggctgcag ctgtccaatg acaacaggac cctcactcta     1140

ctcagtgtca caaggaatga tgtaggaccc tatgagtgtg gaatccagaa cgaattaagt     1200

gttgaccaca gcgacccagt catcctgaat gtcctctatg gcccagacga ccccaccatt     1260

tccccctcat acacctatta ccgtccaggg gtgaacctca gcctctcctg ccatgcagcc     1320

tctaacccac ctgcacagta ttcttggctg attgatggga acatccagca acacacacaa     1380

gagctcttta tctccaacat cactgagaag aacagcggac tctatacctg ccaggccaat     1440

aactcagcca gtggccacag caggactaca gtcaagacaa tcacagtctc tgcggagctg     1500

cccaagccct ccatctccag caacaactcc aaacccgtgg aggacaagga tgctgtggcc     1560

ttcacctgtg aacctgaggc tcagaacaca acctacctgt ggtgggtaaa tggtcagagc     1620

ctcccagtca gtcccaggct gcagctgtcc aatggcaaca ggaccctcac tctattcaat     1680

gtcacaagaa atgacgcaag agcctatgta tgtggaatcc agaactcagt gagtgcaaac     1740

cgcagtgacc cagtcaccct ggatgtcctc tatgggccgg acacccccat catttccccc     1800

ccagactcgt cttacctttc gggagcgaac ctcaacctct cctgccactc ggcctctaac     1860

ccatccccgc agtattcttg gcgtatcaat gggataccgc agcaacacac acaagttctc     1920

tttatcgcca aaatcacgcc aaataataac gggacctatg cctgttttgt ctctaacttg     1980

gctactggcc gcaataattc catagtcaag agcatcacag tctctgcatc tggaacttct     2040

cctggtctct cagctggggc cactgtcggc atcatgattg gagtgctggt tggggttgct     2100

ctgatatag                                                             2109


<210>  69
<211>  2118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  monkey CEA DNA

<400>  69
atggggtctc cctcagcccc tcttcacaga tggtgcatcc cctggcagac gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg cccagctcac tattgaatcc      120

aggccgttca atgttgcaga ggggaaggag gttcttctac ttgcccacaa tgtgtcccag      180

aatctttttg gctacatttg gtacaaggga gaaagagtgg atgccagccg tcgaattgga      240

tcatgtgtaa taagaactca acaaattacc ccagggcccg cacacagcgg tcgagagaca      300

atagacttca atgcatccct gctgatccac aatgtcaccc agagtgacac aggatcctac      360

accatacaag tcataaagga agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctacatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttaacctg tgaacctgag actcaggaca caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctggagctgt ccagtgacaa caggaccctc      600

actgtattca atattccaag aaatgacaca acatcctaca aatgtgaaac ccagaaccca      660

gtgagtgtca gacgcagcga cccagtcacc ctgaacgtcc tctatggccc ggatgcgccc      720

accatttccc ctctaaacac accttacaga gcaggggaaa atctgaacct cacctgccac      780

gcagcctcta acccaactgc acagtacttt tggtttgtca atgggacgtt ccagcaatcc      840

acacaagagc tctttatacc caacatcacc gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cggcgatcac agtctacgcg      960

gagctgccca agccctacat caccagcaac aactccaacc ccatagagga caaggatgct     1020

gtgaccttaa cctgtgaacc tgagactcag gacacaacct acctgtggtg ggtaaacaat     1080

cagagcctct cggtcagttc caggctggag ctgtccaatg acaacaggac cctcactgta     1140

ttcaatattc caagaaacga cacaacgttc tacgaatgtg agacccagaa cccagtgagt     1200

gtcagacgca gcgacccagt caccctgaat gtcctctatg gcccggatgc gcccaccatt     1260

tcccctctaa acacacctta cagagcaggg gaaaatctga acctctcctg ccacgcagcc     1320

tctaacccag ctgcacagta ctcttggttt gtcaatggga cgttccagca atccacacaa     1380

gagctcttta tacccaacat caccgtgaat aatagcggat cctatatgtg ccaagcccat     1440

aactcagcca ctggcctcaa taggaccaca gtcacggcga tcacagtcta tgtggagctg     1500

cccaagccct acatctccag caacaactcc aaccccatag aggacaagga tgctgtgacc     1560

ttaacctgtg aacctgtggc tgagaacaca acctacctgt ggtgggtaaa caatcagagc     1620

ctctcggtca gtcccaggct gcagctctcc aatggcaaca ggatcctcac tctactcagt     1680

gtcacacgga atgacacagg accctatgaa tgtggaatcc agaactcaga gagtgcaaaa     1740

cgcagtgacc cagtcaccct gaatgtcacc tatggcccag acacccccat catatccccc     1800

ccagacttgt cttaccgttc gggagcaaac ctcaacctct cctgccactc ggactctaac     1860

ccatccccgc agtattcttg gcttatcaat gggacactgc ggcaacacac acaagttctc     1920

tttatctcca aaatcacatc aaacaatagc ggggcctatg cctgttttgt ctctaacttg     1980

gctaccggtc gcaataactc catagtcaag aacatctcag tctcctctgg cgattcagca     2040

cctggaagtt ctggtctctc agctagggct actgtcggca tcataattgg aatgctggtt     2100

ggggttgctc tgatgtag                                                   2118


<210>  70
<211>  1035
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  full-length human CEACAM6 DNA

<400>  70
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttccc cctcaaaggc caattaccgt ccaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttatca atgggacgtt ccagcaatcc      840

acacaagagc tctttatccc caacatcact gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cgatgatcac agtctctgga      960

agtgctcctg tcctctcagc tgtggccacc gtcggcatca cgattggagt gctggccagg     1020

gtggctctga tatag                                                      1035


<210>  71
<211>  2079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-687 of huCEA DNA

<400>  71
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgacac aggattctac      360

accctacacg tcataaagtc agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaacccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag actcaggacg caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa caggaccctc      600

actctattca atgtcacaag aaatgacaca gcaagctaca aatgtgaaac ccagaaccca      660

gtgagtgcca ggcgcagtga ttcagtcatc ctgaatgtcc tctatggccc ggatgccccc      720

accatttccc ctctaaacac atcttacaga tcaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttgtca atgggacttt ccagcaatcc      840

acccaagagc tctttatccc caacatcact gtgaataata gtggatccta tacgtgccaa      900

gcccataact cagacactgg cctcaatagg accacagtca cgacgatcac agtctatgca      960

gagccaccca aacccttcat caccagcaac aactccaacc ccgtggagga tgaggatgct     1020

gtagccttaa cctgtgaacc tgagattcag aacacaacct acctgtggtg ggtaaataat     1080

cagagcctcc cggtcagtcc caggctgcag ctgtccaatg acaacaggac cctcactcta     1140

ctcagtgtca caaggaatga tgtaggaccc tatgagtgtg gaatccagaa cgaattaagt     1200

gttgaccaca gcgacccagt catcctgaat gtcctctatg gcccagacga ccccaccatt     1260

tccccctcat acacctatta ccgtccaggg gtgaacctca gcctctcctg ccatgcagcc     1320

tctaacccac ctgcacagta ttcttggctg attgatggga acatccagca acacacacaa     1380

gagctcttta tctccaacat cactgagaag aacagcggac tctatacctg ccaggccaat     1440

aactcagcca gtggccacag caggactaca gtcaagacaa tcacagtctc tgcggagctg     1500

cccaagccct ccatctccag caacaactcc aaacccgtgg aggacaagga tgctgtggcc     1560

ttcacctgtg aacctgaggc tcagaacaca acctacctgt ggtgggtaaa tggtcagagc     1620

ctcccagtca gtcccaggct gcagctgtcc aatggcaaca ggaccctcac tctattcaat     1680

gtcacaagaa atgacgcaag agcctatgta tgtggaatcc agaactcagt gagtgcaaac     1740

cgcagtgacc cagtcaccct ggatgtcctc tatgggccgg acacccccat catttccccc     1800

ccagactcgt cttacctttc gggagcgaac ctcaacctct cctgccactc ggcctctaac     1860

ccatccccgc agtattcttg gcgtatcaat gggataccgc agcaacacac acaagttctc     1920

tttatcgcca aaatcacgcc aaataataac gggacctatg cctgttttgt ctctaacttg     1980

gctactggcc gcaataattc catagtcaag agcatcacag tctctgcatc tggaacttct     2040

cctggtctct cagctggggc ccatcaccat caccatcac                            2079


<210>  72
<211>  2088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-690 of monkey CEA DNA

<400>  72
atggggtctc cctcagcccc tcttcacaga tggtgcatcc cctggcagac gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg cccagctcac tattgaatcc      120

aggccgttca atgttgcaga ggggaaggag gttcttctac ttgcccacaa tgtgtcccag      180

aatctttttg gctacatttg gtacaaggga gaaagagtgg atgccagccg tcgaattgga      240

tcatgtgtaa taagaactca acaaattacc ccagggcccg cacacagcgg tcgagagaca      300

atagacttca atgcatccct gctgatccac aatgtcaccc agagtgacac aggatcctac      360

accatacaag tcataaagga agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctacatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttaacctg tgaacctgag actcaggaca caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctggagctgt ccagtgacaa caggaccctc      600

actgtattca atattccaag aaatgacaca acatcctaca aatgtgaaac ccagaaccca      660

gtgagtgtca gacgcagcga cccagtcacc ctgaacgtcc tctatggccc ggatgcgccc      720

accatttccc ctctaaacac accttacaga gcaggggaaa atctgaacct cacctgccac      780

gcagcctcta acccaactgc acagtacttt tggtttgtca atgggacgtt ccagcaatcc      840

acacaagagc tctttatacc caacatcacc gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cggcgatcac agtctacgcg      960

gagctgccca agccctacat caccagcaac aactccaacc ccatagagga caaggatgct     1020

gtgaccttaa cctgtgaacc tgagactcag gacacaacct acctgtggtg ggtaaacaat     1080

cagagcctct cggtcagttc caggctggag ctgtccaatg acaacaggac cctcactgta     1140

ttcaatattc caagaaacga cacaacgttc tacgaatgtg agacccagaa cccagtgagt     1200

gtcagacgca gcgacccagt caccctgaat gtcctctatg gcccggatgc gcccaccatt     1260

tcccctctaa acacacctta cagagcaggg gaaaatctga acctctcctg ccacgcagcc     1320

tctaacccag ctgcacagta ctcttggttt gtcaatggga cgttccagca atccacacaa     1380

gagctcttta tacccaacat caccgtgaat aatagcggat cctatatgtg ccaagcccat     1440

aactcagcca ctggcctcaa taggaccaca gtcacggcga tcacagtcta tgtggagctg     1500

cccaagccct acatctccag caacaactcc aaccccatag aggacaagga tgctgtgacc     1560

ttaacctgtg aacctgtggc tgagaacaca acctacctgt ggtgggtaaa caatcagagc     1620

ctctcggtca gtcccaggct gcagctctcc aatggcaaca ggatcctcac tctactcagt     1680

gtcacacgga atgacacagg accctatgaa tgtggaatcc agaactcaga gagtgcaaaa     1740

cgcagtgacc cagtcaccct gaatgtcacc tatggcccag acacccccat catatccccc     1800

ccagacttgt cttaccgttc gggagcaaac ctcaacctct cctgccactc ggactctaac     1860

ccatccccgc agtattcttg gcttatcaat gggacactgc ggcaacacac acaagttctc     1920

tttatctcca aaatcacatc aaacaatagc ggggcctatg cctgttttgt ctctaacttg     1980

gctaccggtc gcaataactc catagtcaag aacatctcag tctcctctgg cgattcagca     2040

cctggaagtt ctggtctctc agctagggct catcaccatc accatcac                  2088


<210>  73
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-320 of CEACAM6 DNA

<400>  73
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttccc cctcaaaggc caattaccgt ccaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttatca atgggacgtt ccagcaatcc      840

acacaagagc tctttatccc caacatcact gtgaataata gcggatccta tatgtgccaa      900

gcccataact cagccactgg cctcaatagg accacagtca cgatgatcac agtctctgga      960

catcaccatc accatcac                                                    978


<210>  74
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-78 of huCEA DNA

<400>  74
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaat                      345


<210>  75
<211>  870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  398-687 of huCEA DNA

<400>  75
gaattaagtg ttgaccacag cgacccagtc atcctgaatg tcctctatgg cccagacgac       60

cccaccattt ccccctcata cacctattac cgtccagggg tgaacctcag cctctcctgc      120

catgcagcct ctaacccacc tgcacagtat tcttggctga ttgatgggaa catccagcaa      180

cacacacaag agctctttat ctccaacatc actgagaaga acagcggact ctatacctgc      240

caggccaata actcagccag tggccacagc aggactacag tcaagacaat cacagtctct      300

gcggagctgc ccaagccctc catctccagc aacaactcca aacccgtgga ggacaaggat      360

gctgtggcct tcacctgtga acctgaggct cagaacacaa cctacctgtg gtgggtaaat      420

ggtcagagcc tcccagtcag tcccaggctg cagctgtcca atggcaacag gaccctcact      480

ctattcaatg tcacaagaaa tgacgcaaga gcctatgtat gtggaatcca gaactcagtg      540

agtgcaaacc gcagtgaccc agtcaccctg gatgtcctct atgggccgga cacccccatc      600

atttcccccc cagactcgtc ttacctttcg ggagcgaacc tcaacctctc ctgccactcg      660

gcctctaacc catccccgca gtattcttgg cgtatcaatg ggataccgca gcaacacaca      720

caagttctct ttatcgccaa aatcacgcca aataataacg ggacctatgc ctgttttgtc      780

tctaacttgg ctactggccg caataattcc atagtcaaga gcatcacagt ctctgcatct      840

ggaacttctc ctggtctctc agctggggcc                                       870


<210>  76
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CEA-v DNA

<400>  76
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgaatt aagtgttgac      360

cacagcgacc cagtcatcct gaatgtcctc tatggcccag acgaccccac catttccccc      420

tcatacacct attaccgtcc aggggtgaac ctcagcctct cctgccatgc agcctctaac      480

ccacctgcac agtattcttg gctgattgat gggaacatcc agcaacacac acaagagctc      540

tttatctcca acatcactga gaagaacagc ggactctata cctgccaggc caataactca      600

gccagtggcc acagcaggac tacagtcaag acaatcacag tctctgcgga gctgcccaag      660

ccctccatct ccagcaacaa ctccaaaccc gtggaggaca aggatgctgt ggccttcacc      720

tgtgaacctg aggctcagaa cacaacctac ctgtggtggg taaatggtca gagcctccca      780

gtcagtccca ggctgcagct gtccaatggc aacaggaccc tcactctatt caatgtcaca      840

agaaatgacg caagagccta tgtatgtgga atccagaact cagtgagtgc aaaccgcagt      900

gacccagtca ccctggatgt cctctatggg ccggacaccc ccatcatttc ccccccagac      960

tcgtcttacc tttcgggagc gaacctcaac ctctcctgcc actcggcctc taacccatcc     1020

ccgcagtatt cttggcgtat caatgggata ccgcagcaac acacacaagt tctctttatc     1080

gccaaaatca cgccaaataa taacgggacc tatgcctgtt ttgtctctaa cttggctact     1140

ggccgcaata attccatagt caagagcatc acagtctctg catctggaac ttctcctggt     1200

ctctcagctg gggcccatca ccatcaccat cac                                  1233


<210>  77
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-273 of CEACAM6 DNA

<400>  77
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttcc                                                              729


<210>  78
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  596-687 of huCEA DNA

<400>  78
cccatcattt cccccccaga ctcgtcttac ctttcgggag cgaacctcaa cctctcctgc       60

cactcggcct ctaacccatc cccgcagtat tcttggcgta tcaatgggat accgcagcaa      120

cacacacaag ttctctttat cgccaaaatc acgccaaata ataacgggac ctatgcctgt      180

tttgtctcta acttggctac tggccgcaat aattccatag tcaagagcat cacagtctct      240

gcatctggaa cttctcctgg tctctcagct ggggcc                                276


<210>  79
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIM DNA

<400>  79
atgggacccc cctcagcccc tccctgcaga ttgcatgtcc cctggaagga ggtcctgctc       60

acagcctcac ttctaacctt ctggaaccca cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gttcttctac tcgcccacaa cctgccccag      180

aatcgtattg gttacagctg gtacaaaggc gaaagagtgg atggcaacag tctaattgta      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagaca      300

atatacccca atgcatccct gctgatccag aacgtcaccc agaatgacac aggattctat      360

accctacaag tcataaagtc agatcttgtg aatgaagaag caaccggaca gttccatgta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaccccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag gttcagaaca caacctacct gtggtgggta      540

aatggtcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa catgaccctc      600

actctactca gcgtcaaaag gaacgatgca ggatcctatg aatgtgaaat acagaaccca      660

gcgagtgcca accgcagtga cccagtcacc ctgaatgtcc tctatggccc agatgtcccc      720

accatttccc ccatcatttc ccccccagac tcgtcttacc tttcgggagc gaacctcaac      780

ctctcctgcc actcggcctc taacccatcc ccgcagtatt cttggcgtat caatgggata      840

ccgcagcaac acacacaagt tctctttatc gccaaaatca cgccaaataa taacgggacc      900

tatgcctgtt ttgtctctaa cttggctact ggccgcaata attccatagt caagagcatc      960

acagtctctg catctggaac ttctcctggt ctctcagctg gggcccatca ccatcaccat     1020

cac                                                                   1023


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 HCDR1 (IMGT)

<400>  80

Gly Tyr Ile Phe Thr Ser Tyr Trp 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 HCDR2 (IMGT)

<400>  81

Ile Asn Pro Asn Thr Gly Tyr Thr 
1               5               


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 LCDR1 (IMGT)

<400>  82

Glu Asn Ile Tyr Gly Tyr 
1               5       


<210>  83
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 LCDR2 (IMGT)

<400>  83

Asn Ala 
1       


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 LCDR3 (IMGT)

<400>  84

Gln His His Tyr Gly Thr Pro Tyr Thr 
1               5                   


<210>  85
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 VH

<400>  85

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  86
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13 VL

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Phe Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  87
<211>  330
<212>  PRT
<213>  Homo sapiens

<220>
<223>  IgG1wt

<400>  87

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  88
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   human kappa constant (CL) region

<400>  88

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  89
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 heavy chain

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  90
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 light chain

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  91
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 VH

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Thr Gly Tyr Thr Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  92
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA131 VL

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  93
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1 VL

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  94
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1F VH

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  95
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1F-ph-L VL

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Phe Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  96
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA13-1F-ph-M VL

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Gln Tyr Gly Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Lys Asn Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His His Leu Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  97
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BGA113 VH

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Gln Thr Gly Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Gly Asn Tyr Asn Tyr Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  98
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGA113 VH DNA

<400>  98
caggtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tatttttacc agctattacc tgcattgggt gcgccaggcg      120

ccgggccagg gcctggaatg gattggctat attaacccgc agaccggcta taccagctat      180

gcccagaaat ttcagggccg cgtgaccatg acccgcgata ccagcaccag caccgtgtat      240

atggaactga gcagcctgcg cagcgaagat accgcggtgt attattgcgc gcgcgaatat      300

ggcaactata actatccgct ggattattgg ggccagggca ccctggtgac cgtgagcagc      360


